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SERPINB2 Gene

protein-coding   GIFtS: 66
GCID: GC18P061528

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbols: PLANH2, PAI2)
  See SERPINB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 21 2     Urokinase Inhibitor2 3
PAI21 2 3 5     PAI-22 3
PLANH21 2 3 5     HsT12012
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 21 2     PAI2
Monocyte Arg-Serpin2 3     Plasminogen Activator Inhibitor 22
Placental Plasminogen Activator Inhibitor2 3     Plasminogen Activator Inhibitor, Type II (Arginine-Serpin)2
Serpin B22 3     

External Ids:    HGNC: 85841   Entrez Gene: 50552   Ensembl: ENSG000001976327   OMIM: 1733905   UniProtKB: P051203   

Export aliases for SERPINB2 gene to outside databases

Previous GC identifers: GC18P061393 GC18P061339 GC18P059703 GC18P059294 GC18P059705 GC18P058256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINB2 Gene:
SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a protein-coding gene. Diseases associated with SERPINB2 include gingivitis, and laryngeal carcinoma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120
Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the
endothelial cell-derived PAI-1

Gene Wiki entry for SERPINB2 (Plasminogen activator inhibitor-2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB2 gene promoter:
         c-Fos   C/EBPbeta   c-Rel   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB2 promoter sequence
   Search Chromatin IP Primers for SERPINB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061528:  view genomic region     (about GC identifiers)

Start:
61,538,926 bp from pter      End:
61,571,124 bp from pter
Size:
32,199 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120 (See protein sequence)
Recommended Name: Plasminogen activator inhibitor 2 precursor  
Size: 415 amino acids; 46596 Da
Subunit: Interacts with PSMB1
4 PDB 3D structures from and Proteopedia for SERPINB2:
1BY7 (3D)        1JRR (3D)        2ARQ (3D)        2ARR (3D)    
Secondary accessions: Q96E96

Explore the universe of human proteins at neXtProt for SERPINB2: NX_P05120

Explore proteomics data for SERPINB2 at MOPED

Post-translational modifications: 

  • The signal sequence is not cleaved1
  • Glycosylation2 at Asn75, Asn115, Asn339
  • Modification sites at PhosphoSitePlus

  • See SERPINB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137290.1  NP_002566.1  

    ENSEMBL proteins: 
     ENSP00000385397   ENSP00000299502   ENSP00000402386   ENSP00000397096   ENSP00000401645  
    Reactome Protein details: P05120

    SERPINB2 Human Recombinant Protein Products:

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    antibodies-online peptides for SERPINB2

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    antibodies-online kits for SERPINB2 (68 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR015556 PAI-2
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P05120

    ProtoNet protein and cluster: P05120

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Find genes that share domains with SERPINB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAI2_HUMAN, P05120
    Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the
    endothelial cell-derived PAI-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
         
    Find genes that share ontologies with SERPINB2           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for SERPINB2:
     Decreased Hepatitis C virus re  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased influenza A/WSN/33 r  Decreased melanin production 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Serpinb2):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle 

    Find genes that share phenotypes with SERPINB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SERPINB2: Serpinb2tm1Dgi Serpinb2tm2Dgi

       genOway: Develop your customized and physiologically relevant rodent model for SERPINB2

    miRNA
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    miRTarBase miRNAs that target SERPINB2:
    hsa-mir-124-3p (MIRT023021), hsa-mir-26b-5p (MIRT030054)

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    2 qRT-PCR Assays for microRNAs that regulate SERPINB2:
    hsa-miR-3163 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAI2_HUMAN, P05120: Cytoplasm. Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with SERPINB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    Blood Clotting Cascade0.42
    2Hemostasis
    Hemostasis0.43
    3Translation Insulin regulation of translation
    Cell adhesion PLAU signaling0.35
    4Senescence and Autophagy
    Senescence and Autophagy
    5Dissolution of Fibrin Clot
    Dissolution of Fibrin Clot


    Find genes that share SuperPaths with SERPINB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SERPINB2
        Blood Coagulation Signaling Pathways


    1 GeneGo (Thomson Reuters) Pathway for SERPINB2
        Cell adhesion PLAU signaling

    2 BioSystems Pathways for SERPINB2
        Senescence and Autophagy
    Blood Clotting Cascade


    1 Reactome Pathway for SERPINB2
        Dissolution of Fibrin Clot


    1 Kegg Pathway  (Kegg details for SERPINB2):
        Amoebiasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINB2: 
              Atherosclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SERPINB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SERPINB2 (P051203 ENSP000002995024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF8Q6P2Q93, ENSP000003043504I2D: score=1 STRING: ENSP00000304350
    PSMB1P206183, ENSP000002621934I2D: score=1 STRING: ENSP00000262193
    PLAUP007493, ENSP000003618504I2D: score=2 STRING: ENSP00000361850
    RB1P064003, ENSP000002671634I2D: score=3 STRING: ENSP00000267163
    IRF3Q146533, ENSP000003101274I2D: score=1 STRING: ENSP00000310127
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0042060wound healing ----
    GO:0042730fibrinolysis TAS--

    Find genes that share ontologies with SERPINB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB2 (PAI2)

    2 DrugBank Compounds for SERPINB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--16327990 15640330 15277569 15351849 15944795
    Tenecteplaset- PA (see all 4)191588-94-0target--17141398 3091604 7958159

    Selected Novoseek inferred chemical compound relationships for SERPINB2 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxamflatin 69 6 11004477 (2), 15122596 (1)
    scca1 62.7 2 10527881 (1), 9817977 (1)
    serine 61.3 52 7499264 (2), 8663255 (1), 9674118 (1), 10623892 (1) (see all 31)
    linomide 44.7 4 9811314 (2), 15035809 (1)
    tcdd 44.6 34 8631129 (8), 10198199 (4), 8048063 (3), 7597708 (2) (see all 9)
    cycloheximide 41.2 15 1555580 (2), 1939146 (2), 7974383 (2), 1389210 (1) (see all 7)
    phorbol 38 10 9037208 (2), 8404615 (1), 1650454 (1), 8626560 (1) (see all 5)
    fibrinogen 37 18 10816585 (5), 11460477 (2), 9714995 (2), 17941461 (1) (see all 9)
    manganese superoxide 26.2 4 8144583 (2), 1584804 (1), 1618749 (1)
    matrigel 25.9 1 8187097 (1)



    Find genes that share compounds with SERPINB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINB2 gene (2 alternative transcripts): 
    NM_001143818.1  NM_002575.2  

    Unigene Cluster for SERPINB2:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 2
    Hs.594481  [show with all ESTs]
    Unigene Representative Sequence: NM_001143818
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404622 ENST00000299502(uc002ljo.3) ENST00000413956 ENST00000443281
    ENST00000482254 ENST00000457692(uc010xeu.2)
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    Additional mRNA sequence: 

    AK313159.1 BC012609.1 DQ655954.2 DQ655996.2 DQ655997.2 DQ655998.2 DQ655999.2 DQ656059.2 
    J02685.1 J03603.1 M18082.1 Y00630.1 

    16 DOTS entries:

    DT.448831  DT.95267384  DT.100771067  DT.100889360  DT.95267382  DT.121082646  DT.121082676  DT.100714524 
    DT.100889353  DT.121082665  DT.92024982  DT.95267385  DT.101973254  DT.121082664  DT.100024660  DT.100889359 

    Selected AceView cDNA sequences (see all 337):

    CD742955 AL550163 AL557133 CD366389 CA306460 W42998 CR599277 BE619006 
    BU751919 T49159 AA362185 BX099033 BC012609 BQ023953 CA306160 CR626822 
    CA312894 CD369081 CR594634 NM_002575 CD742549 AL544520 R74493 BP354277 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
    SP1:        -     -           -                                                                           
    SP2:        -     -           -           -     -     -     -                                             
    SP3:                                                                                                      
    SP4:              -           -                                                                           
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for SERPINB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTGTA
    SERPINB2 Expression
    About this image


    SERPINB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Epidermis (Integumentary System)
    SERPINB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594481
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERPINB2: 
              Atherosclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb21 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 80.32(n)1
    75.9(a)1
      1 (50.34 cM)5
    187881  NM_011111.41  NP_035241.11 
     1075114235 
    chicken
    (Gallus gallus)
    Aves SERPINB21 serpin peptidase inhibitor, clade B (ovalbumin), member more 58.48(n)
    51.11(a)
      420896  XM_418982.4  XP_418982.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINB26
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    47(a)
    1 ↔ 1
    GL343311.1(668439-683640)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    serpinb1l46
    (see all 5)
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    (see all 5)
    47(a)
    45(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    16(54874440-54879870) ENSDARG00000095830
    16(54847385-54853822) ENSDARG00000096888


    ENSEMBL Gene Tree for SERPINB2 (if available)
    TreeFam Gene Tree for SERPINB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB2 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINB2 using alignment to 4 protein entries:     PAI2_HUMAN (see all proteins) (see all similar genes):
    PLANH2    SERPINB10    DKFZp686O07189    SCCA1    SERPINB1    SERPINB11
    SERPINB12    SERPINB6    SERPINB9    SERPINB3    SERPINB5    SERPINB4
    SERPINB13    SERPINB8    SCCA2    SERPINA1    SERPINA6    SERPINI1

    Find genes that share paralogs with SERPINB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB2 (see all 519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739645171,2
    C,F--61552973(+) TTAGAA/TGTTAG 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs37605751,2
    C,F,H--61553019(+) GTAAAT/CGGCAA 2 -- us2k16Minor allele frequency- C:0.03NS EA NA 658
    rs796762801,2
    C,F--61553077(+) ATCCTT/GGTTCA 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1410930591,2
    --61553151(+) AAGAAC/TTTGCT 2 -- us2k10--------
    rs1915751001,2
    --61553236(+) ACTGTA/CAGAAT 2 -- us2k10--------
    rs1502800791,2
    --61553255(+) TTCCTA/GTACCA 2 -- us2k10--------
    rs1806924461,2
    --61553261(+) TACCAC/TATCCT 2 -- us2k10--------
    rs729417181,2
    C--61553290(+) TTCTAA/CGTAGA 2 -- us2k10--------
    rs1147156381,2
    F--61553429(+) TAATAC/TGGTGA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1854070741,2
    --61553638(+) CCAGCC/TTGGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB2 (61538926 - 61571124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SERPINB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525889CNV Loss19592680
    esv21739CNV Gain19812545
    nsv909693CNV Gain21882294
    nsv833673CNV Gain17160897
    essv7909CNV CNV17122850
    dgv1034e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SERPINB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB2
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173390    OMIM disorders: --

    7 diseases for SERPINB2:    
    About MalaCards
    gingivitis    laryngeal carcinoma    periodontal disease    bladder carcinoma
    peritonitis    male breast cancer    ovarian cancer


    Find genes that share disorders with SERPINB2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SERPINB2 gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 53 19 8494839 (3), 8878712 (2), 16244774 (2), 11642673 (2) (see all 10)
    metastasis 51.7 45 9421350 (3), 1636163 (3), 9743310 (3), 12778766 (2) (see all 29)
    fibrosarcoma 46.2 10 10469140 (1), 1650454 (1), 11018526 (1), 8261421 (1) (see all 6)
    tumors 45.1 100 11774293 (4), 17219285 (3), 1636163 (3), 10473092 (3) (see all 47)
    stage ovarian cancer 44.1 1 7664262 (1)
    malignant ascites 37.4 5 8253095 (1), 8174965 (1), 1427403 (1)
    monocytic leukemia 37.4 2 2056772 (1), 8212641 (1)
    gingivitis 35.5 11 8814598 (2), 10743860 (2), 15191592 (2), 11163592 (1) (see all 5)
    promyelocytic leukemia 33.2 11 1771617 (2), 1313698 (2), 2363126 (1), 1870266 (1) (see all 5)
    endometrial cancer 30.4 6 1427403 (2), 8253095 (1), 8348499 (1), 11774293 (1) (see all 5)

    Genetic Association Database (GAD): SERPINB2
    Human Genome Epidemiology (HuGE) Navigator: SERPINB2 (21 documents)

    Export disorders for SERPINB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB2 gene, integrated from 10 sources (see all 481):
    (articles sorted by number of sources associating them with SERPINB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PubMed id 2303256)1, 2, 9 Samia J.A.... Webb A.C. (Genomics 1990)
    2. Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis. (PubMed id 19117638)1, 4, 9 Di Bernardo M.C....Houlston R.S. (Lung Cancer 2009)
    3. Genetic polymorphisms and spontaneous preterm birth. (PubMed id 17267840)1, 4, 9 Gibson C.S....Nelson K.B. (Obstet Gynecol 2007)
    4. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5055 HGNC: 8584 AceView: SERPINB2 Ensembl:ENSG00000197632 euGenes: HUgn5055
    ECgene: SERPINB2 Kegg: 5055 H-InvDB: SERPINB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERPINB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB2 gene:
    Search GeneIP for patents involving SERPINB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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