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Aliases for SERPINB2 Gene

Aliases for SERPINB2 Gene

  • Serpin Family B Member 2 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Placental Plasminogen Activator Inhibitor 3 4
  • Monocyte Arg-Serpin 3 4
  • Urokinase Inhibitor 3 4
  • Serpin B2 3 4
  • PLANH2 3 4
  • PAI-2 3 4
  • PAI2 3 4
  • Plasminogen Activator Inhibitor, Type II (Arginine-Serpin) 3
  • Plasminogen Activator Inhibitor 2 3
  • HsT1201 3
  • PAI 3

External Ids for SERPINB2 Gene

Previous HGNC Symbols for SERPINB2 Gene

  • PLANH2
  • PAI2

Previous GeneCards Identifiers for SERPINB2 Gene

  • GC18P061393
  • GC18P061528
  • GC18P061339
  • GC18P059703
  • GC18P059294
  • GC18P059705
  • GC18P058256

Summaries for SERPINB2 Gene

GeneCards Summary for SERPINB2 Gene

SERPINB2 (Serpin Family B Member 2) is a Protein Coding gene. Diseases associated with SERPINB2 include Lipodermatosclerosis and Gingivitis. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Senescence and Autophagy in Cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB10.

UniProtKB/Swiss-Prot for SERPINB2 Gene

  • Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Gene Wiki entry for SERPINB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB2 Gene

Genomics for SERPINB2 Gene

Regulatory Elements for SERPINB2 Gene

Enhancers for SERPINB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G063878 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.4 +9.4 9385 6.0 MXI1 TAF1 JUN MAX CEBPG EBF1 RFX5 GATA2 EED RCOR1 SERPINB2 SERPINB10 SERPINB8 VPS4B
GH18G063830 0.9 Ensembl ENCODE 11.3 -40.0 -39999 3.0 JUND CBFB EED SCRT2 SIN3A JUNB ZBTB40 GABPA SERPINB10 SERPINB2 SERPINB7
GH18G063859 0.8 FANTOM5 ENCODE dbSUPER 12.3 -11.3 -11267 1.4 SERPINB10 SERPINB2 SERPINB8 VPS4B SERPINB7
GH18G063908 1.1 FANTOM5 Ensembl dbSUPER 7.3 +37.2 37209 0.6 PKNOX1 JUNB CREM RELA SERPINB10 SERPINB2 SERPINB8 VPS4B HMSD
GH18G063837 0.4 FANTOM5 15.4 -33.9 -33910 0.1 TCF7L2 SERPINB2 SERPINB5 SERPINB8 VPS4B SERPINB7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERPINB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB2 Gene

Chromosome:
18
Start:
63,871,692 bp from pter
End:
63,903,890 bp from pter
Size:
32,199 bases
Orientation:
Plus strand

Genomic View for SERPINB2 Gene

Genes around SERPINB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB2 Gene

Proteins for SERPINB2 Gene

  • Protein details for SERPINB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05120-PAI2_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 2
    Protein Accession:
    P05120
    Secondary Accessions:
    • Q96E96

    Protein attributes for SERPINB2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46596 Da
    Quaternary structure:
    • Interacts with PSMB1.

    Three dimensional structures from OCA and Proteopedia for SERPINB2 Gene

neXtProt entry for SERPINB2 Gene

Post-translational modifications for SERPINB2 Gene

Other Protein References for SERPINB2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SERPINB2

No data available for DME Specific Peptides for SERPINB2 Gene

Domains & Families for SERPINB2 Gene

Gene Families for SERPINB2 Gene

Protein Domains for SERPINB2 Gene

Suggested Antigen Peptide Sequences for SERPINB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05120

UniProtKB/Swiss-Prot:

PAI2_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB2: view

Function for SERPINB2 Gene

Molecular function for SERPINB2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Gene Ontology (GO) - Molecular Function for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB2: view
genes like me logo Genes that share phenotypes with SERPINB2: view

Animal Models for SERPINB2 Gene

MGI Knock Outs for SERPINB2:

Animal Model Products

CRISPR Products

miRNA for SERPINB2 Gene

miRTarBase miRNAs that target SERPINB2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB2 Gene

Localization for SERPINB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB2 Gene

Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

Pathways & Interactions for SERPINB2 Gene

genes like me logo Genes that share pathways with SERPINB2: view

Pathways by source for SERPINB2 Gene

2 Reactome pathways for SERPINB2 Gene
1 KEGG pathway for SERPINB2 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB2 Gene
1 R&D Systems pathway for SERPINB2 Gene

Gene Ontology (GO) - Biological Process for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042060 wound healing IEA --
GO:0042730 fibrinolysis TAS --
GO:0043066 negative regulation of apoptotic process IEA,TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

No data available for SIGNOR curated interactions for SERPINB2 Gene

Drugs & Compounds for SERPINB2 Gene

(20) Drugs for SERPINB2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma activator, Target 0
Tenecteplase Approved Pharma Target 40

(26) Additional Compounds for SERPINB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB2: view

Transcripts for SERPINB2 Gene

Unigene Clusters for SERPINB2 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for SERPINB2 Gene

GeneLoc Exon Structure for
SERPINB2
ECgene alternative splicing isoforms for
SERPINB2

Expression for SERPINB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB2 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB2 Gene

This gene is overexpressed in Minor Salivary Gland (x17.2) and Esophagus - Mucosa (x17.0).

Protein differential expression in normal tissues from HIPED for SERPINB2 Gene

This gene is overexpressed in Liver (33.5), Cervix (11.9), and Placenta (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SERPINB2 Gene:

SERPINB2

SOURCE GeneReport for Unigene cluster for SERPINB2 Gene:

Hs.594481

Evidence on tissue expression from TISSUES for SERPINB2 Gene

  • Blood(4.9)
  • Nervous system(4.3)
  • Lung(3.5)
  • Skin(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with SERPINB2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB2 Gene

Orthologs for SERPINB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB2 34 35
  • 98.71 (n)
dog
(Canis familiaris)
Mammalia SERPINB2 34 35
  • 83.57 (n)
cow
(Bos Taurus)
Mammalia SERPINB2 34 35 35
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Serpinb2 34 16 35
  • 80.32 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb2 34
  • 77.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB2 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINB2 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINB2 34 35
  • 58.48 (n)
lizard
(Anolis carolinensis)
Reptilia SERPINB2 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii serpinb1l1 35
  • 47 (a)
ManyToMany
serpinb1l4 35
  • 45 (a)
ManyToMany
serpinb1l3 35
  • 43 (a)
ManyToMany
si:ch73-303g23.4 35
  • 43 (a)
ManyToMany
zgc:173729 35
  • 43 (a)
ManyToMany
Species where no ortholog for SERPINB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINB2 Gene

ENSEMBL:
Gene Tree for SERPINB2 (if available)
TreeFam:
Gene Tree for SERPINB2 (if available)

Paralogs for SERPINB2 Gene

Variants for SERPINB2 Gene

Sequence variations from dbSNP and Humsavar for SERPINB2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000081400 -- 63,886,551(+) AGAGA(C/T)CACGC upstream-variant-2KB
rs1000159137 -- 63,891,437(+) CTAGA(C/T)TGAAA utr-variant-5-prime
rs1000230797 -- 63,891,760(+) AAATT(C/T)CTTAG intron-variant
rs1000393730 -- 63,896,737(+) TATAC(C/T)GTACA intron-variant
rs1000766192 -- 63,896,513(+) GTACA(A/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB2 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV gain 19812545
esv2758730 CNV loss 17122850
esv3642785 CNV gain 21293372
esv3642787 CNV loss 21293372
nsv1066552 CNV gain 25217958
nsv1067311 CNV loss 25217958
nsv525889 CNV loss 19592680
nsv833673 CNV gain 17160897

Variation tolerance for SERPINB2 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB2 Gene

Human Gene Mutation Database (HGMD)
SERPINB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB2 Gene

Disorders for SERPINB2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SERPINB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lipodermatosclerosis
  • acute lipodermatosclerosis
gingivitis
  • acute gingivitis
placenta accreta
joint disorders
  • arthropathy
adult respiratory distress syndrome
  • adult rds
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB2

Genetic Association Database (GAD)
SERPINB2
Human Genome Epidemiology (HuGE) Navigator
SERPINB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB2
genes like me logo Genes that share disorders with SERPINB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB2 Gene

Publications for SERPINB2 Gene

  1. Genetic polymorphisms and spontaneous preterm birth. (PMID: 17267840) Gibson C.S. … Nelson K.B. (Obstet Gynecol 2007) 3 22 46 64
  2. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PMID: 2303256) Samia J.A. … Webb A.C. (Genomics 1990) 3 4 22 64
  3. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for SERPINB2 Gene

Sources for SERPINB2 Gene

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