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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERPINB2 Gene

protein-coding GIFtS: 65
GCID: GC18P061528

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbols: PLANH2, PAI2)

Explore 77 diseases affiliated with
SERPINB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2¹ ²		Serpin B2² ³
PAI2¹ ² ³ ⁵		Urokinase Inhibitor² ³
PLANH2¹ ² ³ ⁵		PAI-2² ³
HsT1201¹ ²		PAI²
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2¹ ²		Plasminogen Activator Inhibitor 2²
Monocyte Arg-Serpin² ³		Plasminogen Activator Inhibitor, Type II (Arginine-Serpin)²
Placental Plasminogen Activator Inhibitor² ³

External Ids:	HGNC: 8584¹	Entrez Gene: 5055²	Ensembl: ENSG00000197632⁷	OMIM: 173390⁵	UniProtKB: P05120³

Export aliases for SERPINB2 gene to outside databases

Previous GC identifers: GC18P061393 GC18P061339 GC18P059703 GC18P059294 GC18P059705 GC18P058256

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120

Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial

cell-derived PAI-1

Gene Wiki entry for SERPINB2 (Plasminogen activator inhibitor-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERPINB2 gene promoter:
c-Fos C/EBPbeta c-Rel AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINB2 promoter sequence

Search SABiosciences Chromatin IP Primers for SERPINB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

SERPINB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P061528: view genomic region (about GC identifiers)

Start:	61,538,926 bp from pter	End:	61,571,124 bp from pter
Size:	32,199 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120 (See protein sequence)

Recommended Name: Plasminogen activator inhibitor 2 precursor

Size: 415 amino acids; 46596 Da

Subunit: Interacts with PSMB1

Subcellular location: Cytoplasm. Secreted, extracellular space

4 PDB 3D structures from and Proteopedia for SERPINB2:

1BY7 (3D)

1JRR (3D)

2ARQ (3D)

2ARR (3D)

Secondary accessions: Q96E96

Explore the universe of human proteins at neXtProt for SERPINB2: NX_P05120

Post-translational modifications:

The signal sequence is not cleaved¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05120

SERPINB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137290.1 NP_002566.1

ENSEMBL proteins:

ENSP00000385397 ENSP00000299502 ENSP00000402386 ENSP00000397096 ENSP00000401645

Reactome Protein details: P05120
Human Recombinant Protein Products:

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	Uscn Proteins for SERPINB2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	--	--
GO:0005886	plasma membrane	TAS	--

SERPINB2 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for SERPINB2

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	Uscn ELISAs and CLIAs for SERPINB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERPINB2 for domains About GeneDecksing

4 InterPro domains/families:

IPR015556 Protease_inhib_serine_PAI-2

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P05120

ProtoNet protein and cluster: P05120

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120

Similarity: Belongs to the serpin family. Ov-serpin subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PAI2_HUMAN, P05120

Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial

cell-derived PAI-1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SERPINB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB2:
		hsa-miR-3163 hsa-miR-410
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Gene Editing
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		Search LifeMap BioReagents cell lines for SERPINB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	--

SERPINB2 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for SERPINB2:

Decreased Hepatitis C virus re	Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e
Decreased influenza A/WSN/33 r	Decreased melanin production

Animal Models:
Mouse knock-outs for SERPINB2: Serpinb2^tm1Dgi Serpinb2^tm2Dgi
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Serpinb2):

growth/size	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
muscle

SERPINB2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of Fibrin Clot (Clotting Cascade)

Blood Coagulation Signaling Pathways

0.51

Blood Clotting Cascade

0.36

Development_CNTF receptor signaling

Cell adhesion PLAU signaling

0.35

Cell adhesion_PLAU signaling

0.35

Senescence and Autophagy

Senescence and Autophagy

1.00

Amoebiasis

Amoebiasis

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SERPINB2

Cell adhesion PLAU signaling

1 R&D Systems Pathway for SERPINB2

Blood Coagulation Signaling Pathways

1 GeneGo (Thomson Reuters) Pathway for SERPINB2

Cell adhesion PLAU signaling

2 BioSystems Pathways for SERPINB2

	Senescence and Autophagy
	Blood Clotting Cascade

2 Reactome Pathways for SERPINB2

	Hemostasis
	Dissolution of Fibrin Clot

1 Kegg Pathway (Kegg details for SERPINB2):

Amoebiasis

SERPINB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SERPINB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for SERPINB2 (P05120³ ENSP00000299502⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRPF8	Q6P2Q9³, ENSP00000304350⁴	I2D: score=1 STRING: ENSP00000304350
PSMB1	P20618³, ENSP00000262193⁴	I2D: score=1 STRING: ENSP00000262193
PLAU	P00749³, ENSP00000361850⁴	I2D: score=2 STRING: ENSP00000361850
RB1	P06400³, ENSP00000267163⁴	I2D: score=3 STRING: ENSP00000267163
IRF3	Q14653³, ENSP00000310127⁴	I2D: score=1 STRING: ENSP00000310127

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	TAS	--
GO:0010951	negative regulation of endopeptidase activity	IBA	--
GO:0030162	regulation of proteolysis	IBA	--
GO:0042060	wound healing	--	--
GO:0042730	fibrinolysis	TAS	--

SERPINB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SERPINB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERPINB2

2 DrugBank Compounds for SERPINB2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Urokinase	U-plasminogen activator (see all 3)	9039-53-6	target	--	16327990 15640330 15277569 15351849 15944795
Tenecteplase	t- PA (see all 4)	191588-94-0	target	--	17141398 3091604 7958159

10/44 Novoseek chemical compound relationships for SERPINB2 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oxamflatin	69	6	11004477 (2), 15122596 (1)
scca1	62.7	2	10527881 (1), 9817977 (1)
serine	61.3	52	7499264 (2), 8663255 (1), 9674118 (1), 10623892 (1) (see all 31)
linomide	44.7	4	9811314 (2), 15035809 (1)
tcdd	44.6	34	8631129 (8), 10198199 (4), 8048063 (3), 7597708 (2) (see all 9)
cycloheximide	41.2	15	1555580 (2), 1939146 (2), 7974383 (2), 1389210 (1) (see all 7)
phorbol	38	10	9037208 (2), 8404615 (1), 1650454 (1), 8626560 (1) (see all 5)
fibrinogen	37	18	10816585 (5), 11460477 (2), 9714995 (2), 17941461 (1) (see all 9)
manganese superoxide	26.2	4	8144583 (2), 1584804 (1), 1618749 (1)
matrigel	25.9	1	8187097 (1)

Search CenterWatch for drugs/clinical trials and news about SERPINB2 / PAI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINB2 gene (2 alternative transcripts):

NM_001143818.1 NM_002575.2

Unigene Cluster for SERPINB2:

Serpin peptidase inhibitor, clade B (ovalbumin), member 2

Hs.594481 [show with all ESTs]

Unigene Representative Sequence: NM_001143818

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000404622 ENST00000299502(uc002ljo.3) ENST00000413956 ENST00000443281

ENST00000482254 ENST00000457692(uc010xeu.2)

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		hsa-miR-3163 hsa-miR-410
		SwitchGear 3'UTR luciferase reporter plasmid: SERPINB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB2

Additional cDNA sequence:

AK313159.1 BC012609.1 DQ655954.2 DQ655996.2 DQ655997.2 DQ655998.2 DQ655999.2 DQ656059.2

J02685.1 J03603.1 M18082.1 Y00630.1

16 DOTS entries:

DT.448831 DT.95267384 DT.100771067 DT.100889360 DT.95267382 DT.121082646 DT.121082676 DT.100714524

DT.100889353 DT.121082665 DT.92024982 DT.95267385 DT.101973254 DT.121082664 DT.100024660 DT.100889359

24/337 AceView cDNA sequences (see all 337):

CR604199 BX424585 AL544520 CD366389 BX099033 CD742549 BX424501 CR599277

R74493 AA362185 AL550163 CB854432 CA310353 CA313606 CR616092 W42998

AL557133 D79002 T49159 CD366374 CA306460 NM_002575 CR594634 CA312894

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11
SP1:			-		-				-
SP2:			-		-				-				-		-		-		-
SP3:
SP4:					-				-
SP5:									-

ECgene alternative splicing isoforms for SERPINB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTCTGTA

About this image

SERPINB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See SERPINB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINB2

SOURCE GeneReport for Unigene cluster: Hs.594481

SABiosciences Expression via Pathway-Focused PCR Arrays including SERPINB2:

Atherosclerosis in human mouse rat

Cancer PathwayFinder in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Cellular Senescence in human mouse rat

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SERPINB2 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SERPINB2¹	serpin peptidase inhibitor, clade B (ovalbumin), member more	58.48(n) 51.11(a)		420896 XM_418982.3 XP_418982.1
lizard (Anolis carolinensis)	Reptilia	SERPINB2⁶	--	47(a)	1 ↔ 1	GL343311.1(668648-682166)
zebrafish (Danio rerio)	Actinopterygii	serpinb1l1⁶ si:ch73-303g23.4⁶ (see all 5)	si:ch73-303g23.4 (see all 5)	47(a) 42(a) (see all 5)	many ↔ many many ↔ many (see all 5)	16(54874440-54879870) 16(54891752-54902149)

ENSEMBL Gene Tree for SERPINB2 (if available)
TreeFam Gene Tree for SERPINB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERPINB2 gene

SERPINB7² SERPINB1² SERPINI1² SERPINB5² SERPINB12² SERPINI2² SERPINB10² SERPINB3²

SERPINB4² SERPINE2² SERPINB6² SERPINC1² SERPINB9² SERPINE1² SERPINE3² SERPINB13²

SERPINB8²

18/28 SIMAP similar genes for SERPINB2 using alignment to 4 protein entries: PAI2_HUMAN (see all proteins) (see all similar genes):

PLANH2 SERPINB10 SERPINB6 DKFZp686O07189 SCCA1 SERPINB1

SERPINB11 SERPINB12 SERPINB9 SERPINB3 SERPINB5 SERPINB4

SERPINB13 SERPINB8 SCCA2 SERPINA1 SERPINA6 SERPINI1

SERPINB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73964517^1,2	C,	--	61552973(+)	`TTAGAA/TGTTAG`	2	--	us2k¹		2		WA	120
rs3760575^1,2	C,F,H,	--	61553019(+)	`GTAAAT/CGGCAA`	2	--	us2k¹		6		NS EA NA	658
rs79676280^1,2		--	61553077(+)	`ATCCTT/GGTTCA`	2	--	us2k¹		1		NA	120
rs141093059^1,2		--	61553151(+)	`AAGAAC/TTTGCT`	2	--	us2k¹		0	--	--	--	--
rs191575100^1,2		--	61553236(+)	`ACTGTA/CAGAAT`	2	--	us2k¹		0	--	--	--	--
rs150280079^1,2		--	61553255(+)	`TTCCTA/GTACCA`	2	--	us2k¹		0	--	--	--	--
rs180692446^1,2		--	61553261(+)	`TACCAC/TATCCT`	2	--	us2k¹		0	--	--	--	--
rs72941718^1,2	C,	--	61553290(+)	`TTCTAA/CGTAGA`	2	--	us2k¹		0	--	--	--	--
rs114715638^1,2		--	61553429(+)	`TAATAC/TGGTGA`	2	--	us2k¹		1		WA	118
rs185407074^1,2		--	61553638(+)	`CCAGCC/TTGGCC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERPINB2 (61538926 - 61571124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SERPINB2
2 CNVs: 3172 67377

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERPINB2 for disorders           About GeneDecksing

OMIM gene information: 173390    OMIM disorders: --

20/77 diseases for SERPINB2 (see all 77):    About MalaCards

pre-eclampsia monocytic leukemia b-cell lymphomas myocardial infarction

liver cirrhosis joint disorders esophageal squamous cell carcinoma systemic lupus erythematosus

squamous cell carcinoma lupus erythematosus pancreatic ductal adenocarcinoma ichthyosis

carcinoma laryngitis rheumatoid arthritis gestational diabetes

laryngeal carcinoma ovarian cancer cerebral palsy chronic myeloid leukemia

10/70 Novoseek disease relationships for SERPINB2 gene (see all 70) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia	53	19	8494839 (3), 8878712 (2), 16244774 (2), 11642673 (2) (see all 10)
metastasis	51.7	45	9421350 (3), 1636163 (3), 9743310 (3), 12778766 (2) (see all 29)
fibrosarcoma	46.2	10	10469140 (1), 1650454 (1), 11018526 (1), 8261421 (1) (see all 6)
tumors	45.1	100	11774293 (4), 17219285 (3), 1636163 (3), 10473092 (3) (see all 47)
stage ovarian cancer	44.1	1	7664262 (1)
malignant ascites	37.4	5	8253095 (1), 8174965 (1), 1427403 (1)
monocytic leukemia	37.4	2	2056772 (1), 8212641 (1)
gingivitis	35.5	11	8814598 (2), 10743860 (2), 15191592 (2), 11163592 (1) (see all 5)
promyelocytic leukemia	33.2	11	1771617 (2), 1313698 (2), 2363126 (1), 1870266 (1) (see all 5)
endometrial cancer	30.4	6	1427403 (2), 8253095 (1), 8348499 (1), 11774293 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: SERPINB2 (21 documents)

Export disorders for SERPINB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERPINB2 gene, integrated from 9 sources (see all 473):
(articles sorted by number of sources associating them with SERPINB2)

Utopia: connect your pdf to the dynamic
world of online information

Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PubMed id 2303256)^{1, 2, 9} Samia J.A.... Webb A.C. (1990)
Complex congenital malformations and the impact of the plasminogen activator system and beta-hCG in amniotic fluid. (PubMed id 17141398)^{1, 7} Verkleij-Hagoort A.C....Steegers-Theunissen R.P. (2007)
Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. (PubMed id 14732874)^{1, 2} Fan J.... Zhu Y.S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
The crystal structure of plasminogen activator inhibitor 2 at 2.0-A resolution: implications for serpin function. (PubMed id 10368272)^{1, 2} Harrop S.J.... Curmi P.M.G. (1999)
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{1, 2} Rasmussen H.H....Vandekerckhove J. (1992)
Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin. (PubMed id 2494165)^{1, 2} Ye R.D.... Sadler J.E. (1989)
Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor. (PubMed id 3257578)^{1, 2} Antalis T.M.... Tolstoshev P. (1988)
cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. (PubMed id 3029122)^{1, 2} Ye R.D.... Sadler J.E. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5055	HGNC: 8584	AceView: SERPINB2	Ensembl:ENSG00000197632	euGenes: HUgn5055
ECgene: SERPINB2	Kegg: 5055	H-InvDB: SERPINB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERPINB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SERPINB2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SERPINB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERPINB2 gene:
Search GeneIP for patents involving SERPINB2

GeneCards and IP:
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SERPINB2 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member...

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