Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINB2 Gene

Aliases for SERPINB2 Gene

  • Serpin Family B Member 2 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Placental Plasminogen Activator Inhibitor 3 4
  • Monocyte Arg-Serpin 3 4
  • Urokinase Inhibitor 3 4
  • Serpin B2 3 4
  • PLANH2 3 4
  • PAI-2 3 4
  • PAI2 3 4
  • Plasminogen Activator Inhibitor, Type II (Arginine-Serpin) 3
  • HsT1201 3
  • PAI 3

External Ids for SERPINB2 Gene

Previous HGNC Symbols for SERPINB2 Gene

  • PLANH2
  • PAI2

Previous GeneCards Identifiers for SERPINB2 Gene

  • GC18P061393
  • GC18P061528
  • GC18P061339
  • GC18P059703
  • GC18P059294
  • GC18P059705
  • GC18P058256

Summaries for SERPINB2 Gene

GeneCards Summary for SERPINB2 Gene

SERPINB2 (Serpin Family B Member 2) is a Protein Coding gene. Diseases associated with SERPINB2 include gingivitis and endometrial cancer. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB2 Gene

  • Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Gene Wiki entry for SERPINB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB2 Gene

Genomics for SERPINB2 Gene

Regulatory Elements for SERPINB2 Gene

Genomic Location for SERPINB2 Gene

Chromosome:
18
Start:
63,871,692 bp from pter
End:
63,903,890 bp from pter
Size:
32,199 bases
Orientation:
Plus strand

Genomic View for SERPINB2 Gene

Genes around SERPINB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB2 Gene

Proteins for SERPINB2 Gene

  • Protein details for SERPINB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05120-PAI2_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 2
    Protein Accession:
    P05120
    Secondary Accessions:
    • Q96E96

    Protein attributes for SERPINB2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46596 Da
    Quaternary structure:
    • Interacts with PSMB1.

    Three dimensional structures from OCA and Proteopedia for SERPINB2 Gene

neXtProt entry for SERPINB2 Gene

Proteomics data for SERPINB2 Gene at MOPED

Post-translational modifications for SERPINB2 Gene

Other Protein References for SERPINB2 Gene

Antibody Products

No data available for DME Specific Peptides for SERPINB2 Gene

Domains & Families for SERPINB2 Gene

Gene Families for SERPINB2 Gene

Protein Domains for SERPINB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05120

UniProtKB/Swiss-Prot:

PAI2_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB2: view

Function for SERPINB2 Gene

Molecular function for SERPINB2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
genes like me logo Genes that share phenotypes with SERPINB2: view

Animal Models for SERPINB2 Gene

MGI Knock Outs for SERPINB2:

Animal Model Products

CRISPR Products

miRNA for SERPINB2 Gene

miRTarBase miRNAs that target SERPINB2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB2 Gene

Localization for SERPINB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB2 Gene

Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB2 Gene COMPARTMENTS Subcellular localization image for SERPINB2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

Pathways & Interactions for SERPINB2 Gene

genes like me logo Genes that share pathways with SERPINB2: view

Pathways by source for SERPINB2 Gene

2 BioSystems pathways for SERPINB2 Gene
2 Reactome pathways for SERPINB2 Gene
1 KEGG pathway for SERPINB2 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB2 Gene
1 R&D Systems pathway for SERPINB2 Gene

Gene Ontology (GO) - Biological Process for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with SERPINB2: view

No data available for SIGNOR curated interactions for SERPINB2 Gene

Drugs & Compounds for SERPINB2 Gene

(19) Drugs for SERPINB2 Gene - From: Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma activator, Target 0
Tenecteplase Approved Pharma Target 39

(27) Additional Compounds for SERPINB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB2: view

Transcripts for SERPINB2 Gene

Unigene Clusters for SERPINB2 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for SERPINB2 Gene

GeneLoc Exon Structure for
SERPINB2
ECgene alternative splicing isoforms for
SERPINB2

Expression for SERPINB2 Gene

mRNA expression in normal human tissues for SERPINB2 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB2 Gene

This gene is overexpressed in Minor Salivary Gland (x17.2) and Esophagus - Mucosa (x17.0).

Protein differential expression in normal tissues from HIPED for SERPINB2 Gene

This gene is overexpressed in Liver (33.5), Cervix (11.9), and Placenta (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB2 Gene



SOURCE GeneReport for Unigene cluster for SERPINB2 Gene Hs.594481

genes like me logo Genes that share expression patterns with SERPINB2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SERPINB2 Gene

Orthologs for SERPINB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB2 36
  • 98 (a)
OneToOne
SERPINB2 35
  • 98.71 (n)
  • 98.07 (a)
cow
(Bos Taurus)
Mammalia SERPINB2 36
  • 79 (a)
OneToMany
SERPINB2 36
  • 77 (a)
OneToMany
SERPINB2 35
  • 82.25 (n)
  • 77.11 (a)
dog
(Canis familiaris)
Mammalia SERPINB2 35
  • 83.57 (n)
  • 78.26 (a)
SERPINB2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb2 16
Serpinb2 36
  • 76 (a)
OneToOne
Serpinb2 35
  • 80.32 (n)
  • 75.9 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINB2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb2 35
  • 77.99 (n)
  • 72.77 (a)
chicken
(Gallus gallus)
Aves SERPINB2 35
  • 58.48 (n)
  • 51.11 (a)
SERPINB2 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINB2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii serpinb1l1 36
  • 47 (a)
ManyToMany
serpinb1l3 36
  • 43 (a)
ManyToMany
serpinb1l4 36
  • 45 (a)
ManyToMany
si:ch73-303g23.4 36
  • 43 (a)
ManyToMany
zgc:173729 36
  • 43 (a)
ManyToMany
Species with no ortholog for SERPINB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINB2 Gene

ENSEMBL:
Gene Tree for SERPINB2 (if available)
TreeFam:
Gene Tree for SERPINB2 (if available)

Paralogs for SERPINB2 Gene

genes like me logo Genes that share paralogs with SERPINB2: view

Variants for SERPINB2 Gene

Sequence variations from dbSNP and Humsavar for SERPINB2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs6098 - 63,897,160(+) CAGGG(A/G/T)ATTAT reference, missense
rs6103 - 63,903,269(+) ACCAA(C/G)TGCAT reference, missense
rs6104 - 63,903,295(+) ATTTT(C/G)CTCAC reference, missense
rs6100 - 63,902,411(+) TCAGC(A/G)CACAC reference, missense
rs34066931 - 63,903,178(+) CACAG(C/G)AGGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINB2 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV Gain 19812545
nsv909693 CNV Gain 21882294
nsv525889 CNV Loss 19592680
dgv1034e1 CNV Complex 17122850
nsv833673 CNV Gain 17160897
essv7909 CNV CNV 17122850

Variation tolerance for SERPINB2 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB2 Gene

HapMap Linkage Disequilibrium report
SERPINB2
Human Gene Mutation Database (HGMD)
SERPINB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB2 Gene

Disorders for SERPINB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SERPINB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gingivitis
  • acute gingivitis
endometrial cancer
  • endometrial cancer, familial
papilloma
  • papillomatosis
preeclampsia/eclampsia 1
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB2

Genetic Association Database (GAD)
SERPINB2
Human Genome Epidemiology (HuGE) Navigator
SERPINB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB2
genes like me logo Genes that share disorders with SERPINB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB2 Gene

Publications for SERPINB2 Gene

  1. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PMID: 2303256) Samia J.A. … Webb A.C. (Genomics 1990) 3 4 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Up-regulation of plasminogen activator inhibitor-2 is associated with high-risk HPV and grade of cervical lesion at baseline but does not predict outcomes of high-risk HPV infections or incident CIN. (PMID: 19926580) SyrjAonen S. … SyrjAonen K. (Am. J. Clin. Pathol. 2009) 3 23
  4. Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease. (PMID: 18472001) KardeA9ler L. … KA1tA1kAsA1ler N. (Clin. Biochem. 2008) 3 23
  5. Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions. (PMID: 18690354) Lobov S. … Ranson M. (Thromb. Haemost. 2008) 3 23

Products for SERPINB2 Gene

Sources for SERPINB2 Gene

Back to Top

Content