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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB13 Gene

protein-coding   GIFtS: 55
GCID: GC18P061227

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 131 2     HSHUR7SEQ2
PI131 2 3 5     HUR72
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 131 2     headpin2
HaCaT UV-Repressible Serpin2 3     Protease Inhibitor 13 (Hurpin, Headpin)2
Peptidase Inhibitor 132 3     Serpin B132
Proteinase Inhibitor 132 3     UV-B Repressed Sequence, HUR 72
PI-132 3     Headpin3
HURPIN2 5     Hurpin3

External Ids:    HGNC: 89441   Entrez Gene: 52752   Ensembl: ENSG000001976417   OMIM: 6044455   UniProtKB: Q9UIV83   

Export aliases for SERPINB13 gene to outside databases

Previous GC identifers: GC18P061093 GC18P059403 GC18P059296 GC18P059405 GC18P057954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINB13 Gene: 
SERPINB13 (serpin peptidase inhibitor, clade B (ovalbumin), member 13) is a protein-coding gene. Diseases associated with SERPINB13 include folliculitis, and pyoderma. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB13_HUMAN, Q9UIV8
Function: May play a role in the proliferation or differentiation of keratinocytes

Gene Wiki entry for SERPINB13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB13 gene promoter:
         TBP   AML1a   Ik-3   Gfi-1   c-Rel   GCNF-1   TFIID   FOXO1a   GCNF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB13 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB13 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061227:  view genomic region     (about GC identifiers)

Start:
61,254,223 bp from pter      End:
61,271,873 bp from pter
Size:
17,651 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPB13_HUMAN, Q9UIV8 (See protein sequence)
Recommended Name: Serpin B13  
Size: 391 amino acids; 44276 Da
Subcellular location: Cytoplasm
Secondary accessions: A8K2Q8 Q3MII2 Q9HCX1 Q9UBW1 Q9UKG0
Alternative splicing: 2 isoforms:  Q9UIV8-1   Q9UIV8-2   

Explore the universe of human proteins at neXtProt for SERPINB13: NX_Q9UIV8

Explore proteomics data for SERPINB13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIV8

  • SERPINB13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB13 Protein Expression
    REFSEQ proteins: NP_036529.1  
    ENSEMBL proteins: 
     ENSP00000388300   ENSP00000341584   ENSP00000394592   ENSP00000391156   ENSP00000269489  

    Human Recombinant Protein Products for SERPINB13: 
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    Novus Biologicals SERPINB13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERPINB13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IBA--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    SERPINB13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry Q9UIV8

    ProtoNet protein and cluster: Q9UIV8

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB13_HUMAN, Q9UIV8
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB13_HUMAN, Q9UIV8
    Function: May play a role in the proliferation or differentiation of keratinocytes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS10512713
         
    SERPINB13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SERPINB13:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB13 

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB13:
    hsa-miR-4307 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB13 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINB13 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SERPINB13):
        Amoebiasis


    SERPINB13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for SERPINB13 (Q9UIV83 ENSP000003415844) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078583, ENSP000003420704I2D: score=1 STRING: ENSP00000342070
    PRTN3P241583, ENSP000002343474I2D: score=1 STRING: ENSP00000234347
    CTSGP083113, ENSP000002163364I2D: score=1 STRING: ENSP00000216336
    CTSKP432353, ENSP000002716514I2D: score=1 STRING: ENSP00000271651
    CTSLP077113, ENSP000003453444I2D: score=1 STRING: ENSP00000345344
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009411response to UV TAS9297979
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis NAS10512713

    SERPINB13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB13 (SPB13)

    3 Novoseek inferred chemical compound relationships for SERPINB13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scca1 90.6 2 14647462 (2)
    serine 61.3 20 10512713 (3), 11313015 (2), 12504904 (2), 10527881 (1) (see all 10)
    cysteine 38.2 5 12504904 (2), 12809493 (1), 17697143 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB13 / SPB13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB13 gene: 
    NM_012397.3  

    Unigene Cluster for SERPINB13:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 13
    Hs.241407  [show with all ESTs]
    Unigene Representative Sequence: NM_012397
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431153 ENST00000344731(uc002ljc.3 uc002ljd.3 uc010xep.2 uc010xeq.2 uc010xer.2)
    ENST00000479842 ENST00000438844 ENST00000415733 ENST00000269489
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SERPINB13:
    hsa-miR-4307 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidSERPINB13 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for SERPINB13
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB13

    Additional mRNA sequence: 

    AF169949.1 AJ001696.2 AJ001697.2 AJ001698.1 AK290323.1 AK296797.1 AK298049.1 AK303867.1 
    AK303979.1 AK313486.1 AL050177.1 BC101821.1 BC143402.1 

    5 DOTS entries:

    DT.86844860  DT.121103760  DT.95346969  DT.40117455  DT.97766708 

    20 AceView cDNA sequences:

    CA433041 BU679351 BG698108 AL703073 X98307 AL050177 AJ001696 BM975846 
    BP352276 AL603394 NM_012397 AF169949 BU686890 AJ001698 BU674040 BM988172 
    AL603092 AJ001697 AW873025 BQ353844 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB13    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                            -     -                       -                     
    SP2:                                            -     -                                             
    SP3:        -     -     -                       -     -                                             
    SP4:                                                  -     -     -     -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SERPINB13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERPINB13 Expression
    About this image


    See SERPINB13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB13

    SOURCE GeneReport for Unigene cluster: Hs.241407

    UniProtKB/Swiss-Prot: SPB13_HUMAN, Q9UIV8
    Tissue specificity: Skin specific

        SABiosciences Custom PCR Arrays for SERPINB13
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB13 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb131 , 5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1, 5 80.12(n)1
    75.32(a)1
      1 (50.34 cM)5
    2411961  NM_172852.31  NP_766440.21 
     1069809845 
    chicken
    (Gallus gallus)
    Aves SERPINB66
    serpin B6
    46(a)
    possible ortholog
    2(67719974-67729598)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    44(a)
    44(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343311.1(595295-637065)
    GL343311.1(566764-578510)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    serpinb1l26
    (see all 7)
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    (see all 7)
    43(a)
    41(a)
    (see all 7)
    possible ortholog
    many ↔ many
    (see all 7)
    16(54874440-54879870)
    20(26946246-26949552)


    ENSEMBL Gene Tree for SERPINB13 (if available)
    TreeFam Gene Tree for SERPINB13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB13 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
    SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  
    SERPINE32  SERPINB82  
    18/36 SIMAP similar genes for SERPINB13 using alignment to 5 protein entries:     SPB13_HUMAN (see all proteins) (see all similar genes):
    HUR 7    SCCA1    SERPINB3    SCCA2    PLANH2    SERPINB4
    SERPINB10    SERPINB11    AT3    DKFZp686O07189    SERPINB1    SERPINB7
    SERPINB12    DKFZp686D06190    SERPINB6    SERPINB9    SERPINB2    SERPINB8

    SERPINB13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 SNPs in SERPINB13 are shown (see all 349)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500650271,2
    --61252639(+) AACATC/TGGCAG 1 -- us2k10--------
    rs739617621,2
    C,F--61252662(+) GATTAC/TATGCT 1 -- us2k12Minor allele frequency- T:0.16WA 120
    rs1453974381,2
    --61252663(+) ATTACA/GTGCTT 1 -- us2k10--------
    rs1924446401,2
    --61252664(+) TTACAA/TGCTTG 1 -- us2k10--------
    rs1423673041,2
    --61252695(+) TCAGTA/GTCAGT 1 -- us2k10--------
    rs18092031,2
    C,F,A,H--61252740(-) CTGTTC/GCATAG 1 -- us2k115Minor allele frequency- G:0.49NS EA NA WA 928
    rs1842299811,2
    --61252843(+) TCAACA/GTATAT 1 -- us2k10--------
    rs1882817451,2
    --61252927(+) GAGGTC/TGGGAA 1 -- us2k10--------
    rs1463539611,2
    C--61252989(+) TGGAGA/GTGCTT 1 -- us2k10--------
    rs1391919641,2
    --61253025(+) GTGTGA/GGTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB13 (61254223 - 61271873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINB13:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717204CNV Deletion23290073
    esv2717203CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604445    OMIM disorders: --

    8 diseases for SERPINB13:    About MalaCards
    folliculitis    pyoderma    pyoderma gangrenosum    skin disease
    psoriasis    type 1 diabetes    lung cancer    squamous cell carcinoma


    SERPINB13 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for SERPINB13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 65.6 12 19569240 (5), 14698630 (1), 12874078 (1)
    carcinoma squamous cell 57.6 6 16357159 (2), 11004515 (1), 19569240 (1), 14647462 (1)
    psoriasis 44.3 3 11313015 (1), 15885077 (1), 10512713 (1)
    skin diseases 42.9 3 17697143 (1), 15885077 (1), 10512713 (1)
    neck cancer 37.4 2 11004515 (2)
    skin lesion 33.5 1 10512713 (1)
    carcinoma 1.98 2 11313015 (1), 15885077 (1)
    tumors 1.35 12 16357159 (2), 12874078 (2), 19569240 (2), 14698630 (1)
    cancer 0 1 16357159 (1)

    Genetic Association Database (GAD): SERPINB13
    Human Genome Epidemiology (HuGE) Navigator: SERPINB13 (1 document)

    Export disorders for SERPINB13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB13 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SERPINB13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PubMed id 10512713)1, 2, 3, 9 Abts H.F....Ruzicka T. (1999)
    2. Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis. (PubMed id 11313015)1, 2, 9 Abts H.F.... Ruzicka T. (2001)
    3. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. (PubMed id 10527881)1, 2, 9 Spring P.... Clayman G. (1999)
    4. Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells. (PubMed id 11004515)1, 2, 9 Nakashima T....Clayman G.L. (2000)
    5. Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Analysis of UV-B modulated gene expression in human keratinocytes by mRNA differential display PCR (DD-PCR). (PubMed id 9297979)1, 3 Abts H.F.... Ruzicka T. (1997)
    8. Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas. (PubMed id 15885077)1, 9 Moussali H....Walz M. (2005)
    9. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. (PubMed id 12504904)1, 9 Jayakumar A....Clayman G.L. (2003)
    10. Downregulation of SERPINB13 expression in head and ne ck squamous cell carcinomas associates with poor clinical outcome. (PubMed id 19569240)1, 9 de Koning P.J....Kummer J.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5275 HGNC: 8944 AceView: SERPINB13 Ensembl:ENSG00000197641 euGenes: HUgn5275
    ECgene: SERPINB13 Kegg: 5275 H-InvDB: SERPINB13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB13 gene:
    Search GeneIP for patents involving SERPINB13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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