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Aliases for SERPINB13 Gene

Aliases for SERPINB13 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • HURPIN 3 4 6
  • PI13 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • HaCaT UV-Repressible Serpin 3 4
  • Proteinase Inhibitor 13 3 4
  • Peptidase Inhibitor 13 3 4
  • Headpin 3 4
  • PI-13 3 4
  • Protease Inhibitor 13 (Hurpin, Headpin) 3
  • UV-B Repressed Sequence, HUR 7 3
  • Serpin B13 3
  • HSHUR7SEQ 3
  • HUR7 3

External Ids for SERPINB13 Gene

Previous HGNC Symbols for SERPINB13 Gene

  • PI13

Previous GeneCards Identifiers for SERPINB13 Gene

  • GC18P061093
  • GC18P061227
  • GC18P059403
  • GC18P059296
  • GC18P059405
  • GC18P057954

Summaries for SERPINB13 Gene

GeneCards Summary for SERPINB13 Gene

SERPINB13 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 13) is a Protein Coding gene. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB13 Gene

  • May play a role in the proliferation or differentiation of keratinocytes

Gene Wiki entry for SERPINB13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB13 Gene

Genomics for SERPINB13 Gene

Regulatory Elements for SERPINB13 Gene

Genomic Location for SERPINB13 Gene

Start:
63,586,989 bp from pter
End:
63,604,639 bp from pter
Size:
17,651 bases
Orientation:
Plus strand

Genomic View for SERPINB13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB13 Gene

Proteins for SERPINB13 Gene

  • Protein details for SERPINB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV8-SPB13_HUMAN
    Recommended name:
    Serpin B13
    Protein Accession:
    Q9UIV8
    Secondary Accessions:
    • A8K2Q8
    • Q3MII2
    • Q9HCX1
    • Q9UBW1
    • Q9UKG0

    Protein attributes for SERPINB13 Gene

    Size:
    391 amino acids
    Molecular mass:
    44276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB13 Gene

Proteomics data for SERPINB13 Gene at MOPED

Post-translational modifications for SERPINB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB13 Gene

Antibody Products

No data available for DME Specific Peptides for SERPINB13 Gene

Domains for SERPINB13 Gene

Gene Families for SERPINB13 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB13 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UIV8

UniProtKB/Swiss-Prot:

SPB13_HUMAN :
  • Q9UIV8
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB13: view

Function for SERPINB13 Gene

Molecular function for SERPINB13 Gene

UniProtKB/Swiss-Prot Function: May play a role in the proliferation or differentiation of keratinocytes

Gene Ontology (GO) - Molecular Function for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12504904
GO:0004867 serine-type endopeptidase inhibitor activity NAS 10512713
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 12809493
genes like me logo Genes that share ontologies with SERPINB13: view

Phenotypes for SERPINB13 Gene

GenomeRNAi human phenotypes for SERPINB13:
genes like me logo Genes that share phenotypes with SERPINB13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB13 Gene

Localization for SERPINB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB13 Gene COMPARTMENTS Subcellular localization image for SERPINB13 gene
Compartment Confidence
cytosol 3
extracellular 3
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
GO:0005654 nucleoplasm IDA 12809493
GO:0005730 NOT nucleolus IDA 12809493
GO:0005737 cytoplasm IDA 12809493
genes like me logo Genes that share ontologies with SERPINB13: view

Pathways for SERPINB13 Gene

SuperPathways for SERPINB13 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB13: view

Pathways by source for SERPINB13 Gene

1 KEGG pathway for SERPINB13 Gene

Gene Ontology (GO) - Biological Process for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009411 response to UV TAS 9297979
GO:0010951 negative regulation of endopeptidase activity IDA 12504904
GO:0030162 regulation of proteolysis NAS 10512713
GO:1902173 negative regulation of keratinocyte apoptotic process IMP 12809493
genes like me logo Genes that share ontologies with SERPINB13: view

Compounds for SERPINB13 Gene

(3) Novoseek inferred chemical compound relationships for SERPINB13 Gene

Compound -log(P) Hits PubMed IDs
scca1 90.6 2
serine 61.3 14
cysteine 38.2 4
genes like me logo Genes that share compounds with SERPINB13: view

Transcripts for SERPINB13 Gene

Unigene Clusters for SERPINB13 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5:

Relevant External Links for SERPINB13 Gene

GeneLoc Exon Structure for
SERPINB13
ECgene alternative splicing isoforms for
SERPINB13

Expression for SERPINB13 Gene

mRNA expression in normal human tissues for SERPINB13 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB13 Gene

This gene is overexpressed in Esophagus - Mucosa (20.5), Vagina (15.8), Cervix - Ectocervix (8.0), and Minor Salivary Gland (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB13 Gene

SOURCE GeneReport for Unigene cluster for SERPINB13 Gene Hs.241407

mRNA Expression by UniProt/SwissProt for SERPINB13 Gene

Q9UIV8-SPB13_HUMAN
Tissue specificity: Skin specific
genes like me logo Genes that share expressions with SERPINB13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINB13 Gene

Orthologs for SERPINB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB13 35
  • 99.23 (n)
  • 98.21 (a)
SERPINB13 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB13 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB13 35
  • 83.42 (n)
  • 78.97 (a)
SERPINB13 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb13 35
  • 80.12 (n)
  • 75.32 (a)
Serpinb13 16
Serpinb13 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb13 35
  • 79.43 (n)
  • 74.81 (a)
chicken
(Gallus gallus)
Aves OVALY 36
  • 42 (a)
ManyToMany
SERPINB14 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn43Ab 37
  • 25 (a)
Spn5 37
  • 30 (a)
Spn3 37
  • 31 (a)
CG9460 37
  • 32 (a)
CG6687 37
  • 26 (a)
Spn1 37
  • 32 (a)
CG7722 37
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-6 37
  • 27 (a)
Species with no ortholog for SERPINB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB13 Gene

ENSEMBL:
Gene Tree for SERPINB13 (if available)
TreeFam:
Gene Tree for SERPINB13 (if available)

Paralogs for SERPINB13 Gene

genes like me logo Genes that share paralogs with SERPINB13: view

Variants for SERPINB13 Gene

Sequence variations from dbSNP and Humsavar for SERPINB13 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs715350 -- 63,587,945(+) CATGT(A/G)CAAGC intron-variant
rs715351 -- 63,588,207(+) CACTG(C/T)TTGAA intron-variant
rs897437 -- 63,593,144(-) GCCCT(C/T)CCAAC intron-variant
rs1020693 -- 63,597,234(-) ATGCC(A/G)GTGGC reference, synonymous-codon
rs1020694 - 63,597,064(-) GTAAC(C/T)GTCCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SERPINB13 Gene

Variant ID Type Subtype PubMed ID
esv2717203 CNV Deletion 23290073
esv2717204 CNV Deletion 23290073

Relevant External Links for SERPINB13 Gene

HapMap Linkage Disequilibrium report
SERPINB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB13 Gene

Disorders for SERPINB13 Gene

(9) Novoseek inferred disease relationships for SERPINB13 Gene

Disease -log(P) Hits PubMed IDs
hnscc 65.6 7
carcinoma squamous cell 57.6 5
psoriasis 44.3 3
skin diseases 42.9 3
neck cancer 37.4 2

Relevant External Links for SERPINB13

Genetic Association Database (GAD)
SERPINB13
Human Genome Epidemiology (HuGE) Navigator
SERPINB13
genes like me logo Genes that share disorders with SERPINB13: view

No data available for UniProtKB/Swiss-Prot for SERPINB13 Gene

Publications for SERPINB13 Gene

  1. Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PMID: 10512713) Abts H.F. … Ruzicka T. (J. Mol. Biol. 1999) 2 3 4 23
  2. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. (PMID: 10527881) Spring P. … Clayman G. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells. (PMID: 11004515) Nakashima T. … Clayman G.L. (Biochim. Biophys. Acta 2000) 3 4 23
  4. Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis. (PMID: 11313015) Abts H.F. … Ruzicka T. (DNA Cell Biol. 2001) 3 4 23
  5. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. (PMID: 12504904) Jayakumar A. … Clayman G.L. (Arch. Biochem. Biophys. 2003) 3 23

Products for SERPINB13 Gene

Sources for SERPINB13 Gene

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