Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINB13 Gene

Aliases for SERPINB13 Gene

  • Serpin Family B Member 13 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • HaCaT UV-Repressible Serpin 3 4
  • Proteinase Inhibitor 13 3 4
  • Peptidase Inhibitor 13 3 4
  • Headpin 3 4
  • HURPIN 3 4
  • PI-13 3 4
  • PI13 3 4
  • Protease Inhibitor 13 (Hurpin, Headpin) 3
  • UV-B Repressed Sequence, HUR 7 3
  • Serpin B13 3
  • HUR7 3

External Ids for SERPINB13 Gene

Previous HGNC Symbols for SERPINB13 Gene

  • PI13

Previous GeneCards Identifiers for SERPINB13 Gene

  • GC18P061093
  • GC18P061227
  • GC18P059403
  • GC18P059296
  • GC18P059405
  • GC18P057954

Summaries for SERPINB13 Gene

Entrez Gene Summary for SERPINB13 Gene

  • The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017]

GeneCards Summary for SERPINB13 Gene

SERPINB13 (Serpin Family B Member 13) is a Protein Coding gene. Diseases associated with SERPINB13 include Squamous Cell Carcinoma, Head And Neck and Psoriasis. Among its related pathways are Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB3.

UniProtKB/Swiss-Prot for SERPINB13 Gene

  • May play a role in the proliferation or differentiation of keratinocytes.

Gene Wiki entry for SERPINB13 Gene

Additional gene information for SERPINB13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB13 Gene

Genomics for SERPINB13 Gene

GeneHancer (GH) Regulatory Elements for SERPINB13 Gene

Promoters and enhancers for SERPINB13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063584 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 550.8 -0.8 -754 3.1 MAFF KLF1 MAFK SERPINB13 SERPINB11 SERPINB12
GH18I063603 Enhancer 0.8 Ensembl ENCODE 0.4 +17.5 17488 2.6 USF1 JUNB BATF ATF2 IRF4 JUND ZFHX2 BCL11A SERPINB11 SERPINB13 SERPINB4
GH18I063552 Enhancer 0.6 Ensembl ENCODE 0.3 -33.7 -33748 1.6 POLR2A NFE2 EBF1 SERPINB5 SERPINB12 SERPINB13
GH18I063644 Promoter 0.5 EPDnew 0.2 +57.3 57287 0.1 SERPINB4 SERPINB13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB13 gene promoter:

Genomic Locations for SERPINB13 Gene

Genomic Locations for SERPINB13 Gene
17,651 bases
Plus strand

Genomic View for SERPINB13 Gene

Genes around SERPINB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB13 Gene

Proteins for SERPINB13 Gene

  • Protein details for SERPINB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serpin B13
    Protein Accession:
    Secondary Accessions:
    • A8K2Q8
    • Q3MII2
    • Q9HCX1
    • Q9UBW1
    • Q9UKG0

    Protein attributes for SERPINB13 Gene

    391 amino acids
    Molecular mass:
    44276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB13 Gene


neXtProt entry for SERPINB13 Gene

Post-translational modifications for SERPINB13 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SERPINB13 Gene

Domains & Families for SERPINB13 Gene

Gene Families for SERPINB13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SERPINB13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family. Ov-serpin subfamily.
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB13: view

Function for SERPINB13 Gene

Molecular function for SERPINB13 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the proliferation or differentiation of keratinocytes.

Phenotypes From GWAS Catalog for SERPINB13 Gene

Gene Ontology (GO) - Molecular Function for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12504904
GO:0004867 serine-type endopeptidase inhibitor activity NAS 10512713
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 12809493
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB13: view
genes like me logo Genes that share phenotypes with SERPINB13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB13 Gene

Localization for SERPINB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB13 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA,IEA --
GO:0005654 nucleoplasm IDA 12809493
GO:0005730 NOT nucleolus IDA 12809493
GO:0005737 cytoplasm IEA,IDA 12809493
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SERPINB13: view

Pathways & Interactions for SERPINB13 Gene

SuperPathways for SERPINB13 Gene

SuperPathway Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB13: view

Pathways by source for SERPINB13 Gene

1 KEGG pathway for SERPINB13 Gene

Gene Ontology (GO) - Biological Process for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009411 response to UV TAS 9297979
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IDA 12504904
GO:0030162 regulation of proteolysis NAS 10512713
GO:0045616 regulation of keratinocyte differentiation TAS --
genes like me logo Genes that share ontologies with SERPINB13: view

No data available for SIGNOR curated interactions for SERPINB13 Gene

Drugs & Compounds for SERPINB13 Gene

(2) Drugs for SERPINB13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SERPINB13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB13: view

Transcripts for SERPINB13 Gene

Unigene Clusters for SERPINB13 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - - -

Relevant External Links for SERPINB13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINB13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB13 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB13 Gene

This gene is overexpressed in Esophagus - Mucosa (x20.5), Vagina (x15.8), Cervix - Ectocervix (x8.0), and Minor Salivary Gland (x5.2).

Protein differential expression in normal tissues from HIPED for SERPINB13 Gene

This gene is overexpressed in Oral epithelium (26.3), Cervix (13.1), Urine (11.3), and Saliva (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB13 Gene

Protein tissue co-expression partners for SERPINB13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB13 Gene:


SOURCE GeneReport for Unigene cluster for SERPINB13 Gene:


mRNA Expression by UniProt/SwissProt for SERPINB13 Gene:

Tissue specificity: Skin specific.

Evidence on tissue expression from TISSUES for SERPINB13 Gene

  • Skin(4.4)
genes like me logo Genes that share expression patterns with SERPINB13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB13 Gene

Orthologs for SERPINB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERPINB13 33 34
  • 99.23 (n)
(Canis familiaris)
Mammalia SERPINB13 33 34
  • 83.42 (n)
(Mus musculus)
Mammalia Serpinb13 33 16 34
  • 80.12 (n)
(Rattus norvegicus)
Mammalia Serpinb13 33
  • 79.43 (n)
(Bos Taurus)
Mammalia SERPINB13 34
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
-- 34
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves OVALY 34
  • 42 (a)
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
-- 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9460 35
  • 32 (a)
Spn1 35
  • 32 (a)
Spn3 35
  • 31 (a)
Spn5 35
  • 30 (a)
CG6687 35
  • 26 (a)
CG7722 35
  • 25 (a)
Spn43Ab 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea srp-6 35
  • 27 (a)
Species where no ortholog for SERPINB13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB13 Gene

Gene Tree for SERPINB13 (if available)
Gene Tree for SERPINB13 (if available)

Paralogs for SERPINB13 Gene

Variants for SERPINB13 Gene

Sequence variations from dbSNP and Humsavar for SERPINB13 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs864622008 uncertain-significance, Malignant tumor of prostate 63,597,080(+) C/T coding_sequence_variant, missense_variant
rs1000016646 -- 63,593,372(+) C/T intron_variant
rs1000369284 -- 63,593,783(+) T/A intron_variant
rs1000862780 -- 63,586,325(+) C/T upstream_transcript_variant
rs1000971638 -- 63,592,084(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB13 Gene

Variant ID Type Subtype PubMed ID
esv2717203 CNV deletion 23290073
esv2717204 CNV deletion 23290073
nsv1066552 CNV gain 25217958

Variation tolerance for SERPINB13 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINB13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB13 Gene

Disorders for SERPINB13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SERPINB13 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINB13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERPINB13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB13 Gene

Publications for SERPINB13 Gene

  1. Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PMID: 10512713) Abts HF … Ruzicka T (Journal of molecular biology 1999) 2 3 4 22 58
  2. Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis. (PMID: 11313015) Abts HF … Ruzicka T (DNA and cell biology 2001) 3 4 22 58
  3. Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells. (PMID: 11004515) Nakashima T … Clayman GL (Biochimica et biophysica acta 2000) 3 4 22 58
  4. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. (PMID: 10527881) Spring P … Clayman G (Biochemical and biophysical research communications 1999) 3 4 22 58
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58

Products for SERPINB13 Gene

Sources for SERPINB13 Gene

Loading form....