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Aliases for SERPINB13 Gene

Aliases for SERPINB13 Gene

  • Serpin Family B Member 13 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 13 2 3
  • HaCaT UV-Repressible Serpin 3 4
  • Proteinase Inhibitor 13 3 4
  • Peptidase Inhibitor 13 3 4
  • Headpin 3 4
  • HURPIN 3 4
  • PI-13 3 4
  • PI13 3 4
  • Protease Inhibitor 13 (Hurpin, Headpin) 3
  • UV-B Repressed Sequence, HUR 7 3
  • Serpin B13 3
  • HSHUR7SEQ 3
  • HUR7 3

External Ids for SERPINB13 Gene

Previous HGNC Symbols for SERPINB13 Gene

  • PI13

Previous GeneCards Identifiers for SERPINB13 Gene

  • GC18P061093
  • GC18P061227
  • GC18P059403
  • GC18P059296
  • GC18P059405
  • GC18P057954

Summaries for SERPINB13 Gene

GeneCards Summary for SERPINB13 Gene

SERPINB13 (Serpin Family B Member 13) is a Protein Coding gene. Diseases associated with SERPINB13 include Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB3.

UniProtKB/Swiss-Prot for SERPINB13 Gene

  • May play a role in the proliferation or differentiation of keratinocytes.

Gene Wiki entry for SERPINB13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB13 Gene

Genomics for SERPINB13 Gene

Regulatory Elements for SERPINB13 Gene

Enhancers for SERPINB13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F063584 0.7 Ensembl ENCODE 0.8 -0.8 -801 3.2 KLF1 ZNF316 MAFK SERPINB11 SERPINB12 SERPINB13
GH18F063603 0.9 Ensembl ENCODE 0.3 +17.5 17489 2.6 ZFP64 ZBTB11 ZNF140 JUNB ZNF623 ZNF518A ZNF781 ZFHX2 JUND SERPINB11 SERPINB13 SERPINB4
GH18F063552 0.7 Ensembl ENCODE 0.3 -33.7 -33748 1.6 NFE2 EBF1 SERPINB5 SERPINB12 SERPINB13
GH18F063607 0.2 Ensembl 0.3 +20.1 20112 0.2 SERPINB13 SERPINB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERPINB13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB13 Gene

Chromosome:
18
Start:
63,586,989 bp from pter
End:
63,604,639 bp from pter
Size:
17,651 bases
Orientation:
Plus strand

Genomic View for SERPINB13 Gene

Genes around SERPINB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB13 Gene

Proteins for SERPINB13 Gene

  • Protein details for SERPINB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIV8-SPB13_HUMAN
    Recommended name:
    Serpin B13
    Protein Accession:
    Q9UIV8
    Secondary Accessions:
    • A8K2Q8
    • Q3MII2
    • Q9HCX1
    • Q9UBW1
    • Q9UKG0

    Protein attributes for SERPINB13 Gene

    Size:
    391 amino acids
    Molecular mass:
    44276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB13 Gene

Post-translational modifications for SERPINB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB13 Gene

No data available for DME Specific Peptides for SERPINB13 Gene

Domains & Families for SERPINB13 Gene

Gene Families for SERPINB13 Gene

Protein Domains for SERPINB13 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UIV8

UniProtKB/Swiss-Prot:

SPB13_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB13: view

Function for SERPINB13 Gene

Molecular function for SERPINB13 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the proliferation or differentiation of keratinocytes.

Gene Ontology (GO) - Molecular Function for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12504904
GO:0004867 serine-type endopeptidase inhibitor activity NAS 10512713
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 12809493
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB13: view
genes like me logo Genes that share phenotypes with SERPINB13: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB13 Gene

Localization for SERPINB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINB13 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IBA --
GO:0005654 nucleoplasm IDA 12809493
GO:0005730 NOT nucleolus IDA 12809493
GO:0005737 cytoplasm IEA,IDA 12809493
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERPINB13: view

Pathways & Interactions for SERPINB13 Gene

SuperPathways for SERPINB13 Gene

SuperPathway Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB13: view

Pathways by source for SERPINB13 Gene

1 KEGG pathway for SERPINB13 Gene

Gene Ontology (GO) - Biological Process for SERPINB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009411 response to UV TAS 9297979
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IDA 12504904
GO:0030162 regulation of proteolysis NAS 10512713
GO:1902173 negative regulation of keratinocyte apoptotic process IMP 12809493
genes like me logo Genes that share ontologies with SERPINB13: view

No data available for SIGNOR curated interactions for SERPINB13 Gene

Drugs & Compounds for SERPINB13 Gene

(2) Drugs for SERPINB13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SERPINB13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB13: view

Transcripts for SERPINB13 Gene

Unigene Clusters for SERPINB13 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5:

Relevant External Links for SERPINB13 Gene

GeneLoc Exon Structure for
SERPINB13
ECgene alternative splicing isoforms for
SERPINB13

Expression for SERPINB13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB13 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB13 Gene

This gene is overexpressed in Esophagus - Mucosa (x20.5), Vagina (x15.8), Cervix - Ectocervix (x8.0), and Minor Salivary Gland (x5.2).

Protein differential expression in normal tissues from HIPED for SERPINB13 Gene

This gene is overexpressed in Oral epithelium (26.3), Cervix (13.1), Urine (11.3), and Saliva (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB13 Gene



Protein tissue co-expression partners for SERPINB13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB13 Gene:

SERPINB13

SOURCE GeneReport for Unigene cluster for SERPINB13 Gene:

Hs.241407

mRNA Expression by UniProt/SwissProt for SERPINB13 Gene:

Q9UIV8-SPB13_HUMAN
Tissue specificity: Skin specific.
genes like me logo Genes that share expression patterns with SERPINB13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINB13 Gene

Orthologs for SERPINB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB13 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia SERPINB13 34 35
  • 83.42 (n)
mouse
(Mus musculus)
Mammalia Serpinb13 34 16 35
  • 80.12 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb13 34
  • 79.43 (n)
cow
(Bos Taurus)
Mammalia SERPINB13 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves OVALY 35
  • 42 (a)
ManyToMany
SERPINB14 35
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9460 36
  • 32 (a)
Spn1 36
  • 32 (a)
Spn3 36
  • 31 (a)
Spn5 36
  • 30 (a)
CG6687 36
  • 26 (a)
CG7722 36
  • 25 (a)
Spn43Ab 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-6 36
  • 27 (a)
Species where no ortholog for SERPINB13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB13 Gene

ENSEMBL:
Gene Tree for SERPINB13 (if available)
TreeFam:
Gene Tree for SERPINB13 (if available)

Paralogs for SERPINB13 Gene

Variants for SERPINB13 Gene

Sequence variations from dbSNP and Humsavar for SERPINB13 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs864622008 Uncertain significance 63,597,080(+) AGAGG(C/T)GGTCC reference, missense
rs1020693 -- 63,597,234(-) ATGCC(A/G)GTGGC reference, synonymous-codon
rs1020694 -- 63,597,064(-) GTAAC(C/T)GTCCT reference, missense
rs111371535 -- 63,593,552(+) CTTAT(C/T)CCATT intron-variant
rs111490638 -- 63,591,983(+) TCGTC(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB13 Gene

Variant ID Type Subtype PubMed ID
nsv1066552 CNV gain 25217958
esv2717204 CNV deletion 23290073
esv2717203 CNV deletion 23290073

Variation tolerance for SERPINB13 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB13 Gene

Disorders for SERPINB13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERPINB13 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB13

Genetic Association Database (GAD)
SERPINB13
Human Genome Epidemiology (HuGE) Navigator
SERPINB13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB13
genes like me logo Genes that share disorders with SERPINB13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB13 Gene

Publications for SERPINB13 Gene

  1. Cloning and characterization of hurpin (Protease Inhibitor 13): a new skin specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. (PMID: 10512713) Abts H.F. … Ruzicka T. (J. Mol. Biol. 1999) 2 3 4 22 64
  2. Sequence, organization, chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin (PI13), which is up-regulated in psoriasis. (PMID: 11313015) Abts H.F. … Ruzicka T. (DNA Cell Biol. 2001) 3 4 22 64
  3. Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells. (PMID: 11004515) Nakashima T. … Clayman G.L. (Biochim. Biophys. Acta 2000) 3 4 22 64
  4. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. (PMID: 10527881) Spring P. … Clayman G. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64

Products for SERPINB13 Gene

Sources for SERPINB13 Gene

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