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Aliases for SERPINB12 Gene

Aliases for SERPINB12 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serpin B12 3
  • YUKOPIN 3

External Ids for SERPINB12 Gene

Summaries for SERPINB12 Gene

GeneCards Summary for SERPINB12 Gene

SERPINB12 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB1.

UniProtKB/Swiss-Prot for SERPINB12 Gene

  • Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB12 Gene

Genomics for SERPINB12 Gene

Genomic Location for SERPINB12 Gene

Start:
63,556,160 bp from pter
End:
63,567,103 bp from pter
Size:
10,944 bases
Orientation:
Plus strand

Genomic View for SERPINB12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB12 Gene

Regulatory Elements for SERPINB12 Gene

Proteins for SERPINB12 Gene

  • Protein details for SERPINB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P63-SPB12_HUMAN
    Recommended name:
    Serpin B12
    Protein Accession:
    Q96P63
    Secondary Accessions:
    • Q3SYB4

    Protein attributes for SERPINB12 Gene

    Size:
    405 amino acids
    Molecular mass:
    46276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB12 Gene

Proteomics data for SERPINB12 Gene at MOPED

Post-translational modifications for SERPINB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB12 Gene

Domains for SERPINB12 Gene

Gene Families for SERPINB12 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SPB12_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • Q96P63
genes like me logo Genes that share domains with SERPINB12: view

Function for SERPINB12 Gene

Molecular function for SERPINB12 Gene

UniProtKB/Swiss-Prot Function: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator

Gene Ontology (GO) - Molecular Function for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IMP 11604408
GO:0019899 enzyme binding NAS 11604408
genes like me logo Genes that share ontologies with SERPINB12: view

Phenotypes for SERPINB12 Gene

GenomeRNAi human phenotypes for SERPINB12:
genes like me logo Genes that share phenotypes with SERPINB12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB12 Gene

Localization for SERPINB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB12 Gene COMPARTMENTS Subcellular localization image for SERPINB12 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm NAS 11604408
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERPINB12: view

Pathways for SERPINB12 Gene

SuperPathways for SERPINB12 Gene

No Data Available

Interacting Proteins for SERPINB12 Gene

Gene Ontology (GO) - Biological Process for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
GO:0042177 negative regulation of protein catabolic process NAS 11604408
genes like me logo Genes that share ontologies with SERPINB12: view

No data available for Pathways by source for SERPINB12 Gene

Transcripts for SERPINB12 Gene

mRNA/cDNA for SERPINB12 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB12 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB12 Gene

No ASD Table

Relevant External Links for SERPINB12 Gene

GeneLoc Exon Structure for
SERPINB12
ECgene alternative splicing isoforms for
SERPINB12

Expression for SERPINB12 Gene

mRNA expression in normal human tissues for SERPINB12 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB12 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (14.7), Skin - Sun Exposed (Lower leg) (14.5), Vagina (13.8), and Cervix - Ectocervix (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB12 Gene

SOURCE GeneReport for Unigene cluster for SERPINB12 Gene Hs.348541

mRNA Expression by UniProt/SwissProt for SERPINB12 Gene

Q96P63-SPB12_HUMAN
Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine
genes like me logo Genes that share expressions with SERPINB12: view

Orthologs for SERPINB12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB12 36
  • 99.34 (n)
  • 99.51 (a)
SERPINB12 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB12 37
  • 73 (a)
OneToOne
SERPINB13 36
  • 82.55 (n)
  • 80 (a)
dog
(Canis familiaris)
Mammalia SERPINB12 36
  • 85.19 (n)
  • 82.47 (a)
SERPINB12 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb12 36
  • 78.68 (n)
  • 72.84 (a)
Serpinb12 16
Serpinb12 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINB12 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb12 36
  • 79.01 (n)
  • 73.09 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 45 (a)
OneToMany
SERPINB12 36
  • 58.04 (n)
  • 48.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn3 38
  • 31 (a)
Spn2 38
  • 33 (a)
CG6687 38
  • 26 (a)
CG6717 38
  • 28 (a)
CG7722 38
  • 28 (a)
Species with no ortholog for SERPINB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB12 Gene

ENSEMBL:
Gene Tree for SERPINB12 (if available)
TreeFam:
Gene Tree for SERPINB12 (if available)

Paralogs for SERPINB12 Gene

genes like me logo Genes that share paralogs with SERPINB12: view

Variants for SERPINB12 Gene

Sequence variations from dbSNP and Humsavar for SERPINB12 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs749545 -- 63,566,579(-) TTTAG(C/T)ATCAG intron-variant
rs755163 -- 63,565,902(+) TTTAA(A/G)TTTTC intron-variant
rs897438 -- 63,565,891(-) AACTT(C/T)TCAAG intron-variant
rs1111283 -- 63,556,063(-) CATAC(C/T)TGAAA upstream-variant-2KB
rs1378518 -- 63,558,071(-) tttca(C/T)agata intron-variant

Relevant External Links for SERPINB12 Gene

HapMap Linkage Disequilibrium report
SERPINB12

No data available for Structural Variations from Database of Genomic Variants (DGV) for SERPINB12 Gene

Disorders for SERPINB12 Gene

Relevant External Links for SERPINB12

Genetic Association Database (GAD)
SERPINB12
genes like me logo Genes that share disorders with SERPINB12: view

No data available for UniProtKB/Swiss-Prot for SERPINB12 Gene

Publications for SERPINB12 Gene

  1. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. (PMID: 11604408) Askew Y.S. … Silverman G.A. (J. Biol. Chem. 2001) 3 4
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for SERPINB12 Gene

Sources for SERPINB12 Gene

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