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SERPINB12 Gene

protein-coding   GIFtS: 50
GCID: GC18P061196

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 121 2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 121 2
YUKOPIN2
Serpin B122

External Ids:    HGNC: 142201   Entrez Gene: 897772   Ensembl: ENSG000001666347   OMIM: 6156625   UniProtKB: Q96P633   

Export aliases for SERPINB12 gene to outside databases

Previous GC identifers: GC18P061062 GC18P059372 GC18P059374 GC18P057923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINB12 Gene:
SERPINB12 (serpin peptidase inhibitor, clade B (ovalbumin), member 12) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and enzyme binding. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63
Function: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen
activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB12 gene promoter:
         Brachyury   STAT5A   C/EBPalpha   CHOP-10   PPAR-gamma1   CBF-B   CBF-A   PPAR-gamma2   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB12 promoter sequence
   Search Chromatin IP Primers for SERPINB12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB12 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061196:  view genomic region     (about GC identifiers)

Start:
61,223,393 bp from pter      End:
61,234,244 bp from pter
Size:
10,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63 (See protein sequence)
Recommended Name: Serpin B12  
Size: 405 amino acids; 46276 Da

Explore the universe of human proteins at neXtProt for SERPINB12: NX_Q96P63

Explore proteomics data for SERPINB12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERPINB12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_536722.1  
    ENSEMBL proteins: 
     ENSP00000269491   ENSP00000372218  

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    antibodies-online peptides for SERPINB12

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    antibodies-online antibodies for SERPINB12 (43 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry Q96P63

    ProtoNet protein and cluster: Q96P63

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Find genes that share domains with SERPINB12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB12_HUMAN, Q96P63
    Function: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen
    activator

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IMP11604408
    GO:0019899enzyme binding NAS11604408
         
    Find genes that share ontologies with SERPINB12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB12:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB12
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPB12_HUMAN, Q96P63: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm NAS11604408

    Find genes that share ontologies with SERPINB12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINB12
    Interactions:

        Search GeneGlobe Interaction Network for SERPINB12

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SERPINB12 (Q96P633 ENSP000002694914) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=1 STRING: ENSP00000321853
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    AMBRA1Q9C0C73I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    ATG12O948173I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0042177negative regulation of protein catabolic process NAS11604408

    Find genes that share ontologies with SERPINB12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB12 (SPB12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINB12 gene: 
    NM_080474.1  

    Unigene Cluster for SERPINB12:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 12
    Hs.348541  [show with all ESTs]
    Unigene Representative Sequence: AK309754
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269491(uc010xen.2) ENST00000382768(uc010xeo.2)
    miRNA
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    Additional mRNA sequence: 

    AF411191.1 AK309754.1 BC103884.1 BC103885.1 

    2 DOTS entries:

    DT.40114024  DT.95152559 

    8 AceView cDNA sequences:

    AF411191 NM_080474 W74427 BG677045 AA242834 BX090362 W79181 AA242969 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTACGG
    SERPINB12 Expression
    About this image

    SERPINB12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348541

    UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63
    Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver,
    pancreas, testis, ovary, and intestine

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB12 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb121 , 5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1, 5 78.68(n)1
    72.84(a)1
      1 (50.34 cM)5
    718691  NM_027971.21  NP_082247.11 
     1069344495 
    chicken
    (Gallus gallus)
    Aves SERPINB121 serpin peptidase inhibitor, clade B (ovalbumin), member more 58.04(n)
    48.73(a)
      420899  XM_418985.3  XP_418985.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 → many
    GL343247.1(1897189-1916224)


    ENSEMBL Gene Tree for SERPINB12 (if available)
    TreeFam Gene Tree for SERPINB12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB12 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINI22  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    Selected SIMAP similar genes for SERPINB12 using alignment to 3 protein entries:     SPB12_HUMAN (see all proteins) (see all similar genes):
    SCCA1    AT3    PLANH2    DKFZp686O07189    SERPINB11    DKFZp686D06190
    SERPINB10    SERPINB3    SERPINB8    SERPINB1    SCCA2    SERPINB4
    SERPINB9    SERPINB13    SERPINB2    SERPINB6    SERPINB7    SERPINB5

    Find genes that share paralogs with SERPINB12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB12 (see all 373)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782624691,2
    C--61221425(+) CAGTTG/AAGGGG 1 -- us2k13Minor allele frequency- A:0.15CSA NA EA 242
    rs1507708821,2
    --61221466(+) ATTACG/TTAGTT 1 -- us2k10--------
    rs1176439431,2
    C,F--61221476(+) TTGGGG/ACCAAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1392225571,2
    C--61221610(+) TTTTAA/GAAAGT 1 -- us2k10--------
    rs129684301,2
    C,F--61221627(+) ATGTTA/TTCTTT 1 -- us2k17Minor allele frequency- T:0.29NA WA EA 366
    rs745844821,2
    C--61221655(+) GGCTAA/TGAAAA 1 -- us2k10--------
    rs797260401,2
    C--61221656(+) GCTAAC/GAAAAT 1 -- us2k10--------
    rs775520351,2
    C--61221657(+) CTAAGA/TAAATC 1 -- us2k10--------
    rs1495392161,2
    C--61221739(+) TGGTGC/TGCTGT 1 -- us2k10--------
    rs1899154651,2
    --61221768(+) AAATAA/GGAGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINB12 (61223393 - 61234244 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SERPINB12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB12
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615662    OMIM disorders: --


    Find genes that share disorders with SERPINB12           About GenesLikeMe

    Genetic Association Database (GAD): SERPINB12

    Export disorders for SERPINB12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB12 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SERPINB12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    2. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. (PubMed id 11604408)1, 2 Askew Y.S.... Silverman G.A. (J. Biol. Chem. 2001)
    3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    4. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89777 HGNC: 14220 AceView: SERPINB12 Ensembl:ENSG00000166634 euGenes: HUgn89777
    ECgene: SERPINB12 H-InvDB: SERPINB12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB12 gene:
    Search GeneIP for patents involving SERPINB12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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