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Aliases for SERPINB12 Gene

Aliases for SERPINB12 Gene

  • Serpin Family B Member 12 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • YUKOPIN 3

External Ids for SERPINB12 Gene

Previous GeneCards Identifiers for SERPINB12 Gene

  • GC18P061062
  • GC18P061196
  • GC18P059372
  • GC18P059374
  • GC18P057923

Summaries for SERPINB12 Gene

GeneCards Summary for SERPINB12 Gene

SERPINB12 (Serpin Family B Member 12) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINC1.

UniProtKB/Swiss-Prot for SERPINB12 Gene

  • Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB12 Gene

Genomics for SERPINB12 Gene

Regulatory Elements for SERPINB12 Gene

Genomic Location for SERPINB12 Gene

Chromosome:
18
Start:
63,519,090 bp from pter
End:
63,569,329 bp from pter
Size:
50,240 bases
Orientation:
Plus strand

Genomic View for SERPINB12 Gene

Genes around SERPINB12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB12 Gene

Proteins for SERPINB12 Gene

  • Protein details for SERPINB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P63-SPB12_HUMAN
    Recommended name:
    Serpin B12
    Protein Accession:
    Q96P63
    Secondary Accessions:
    • Q3SYB4

    Protein attributes for SERPINB12 Gene

    Size:
    405 amino acids
    Molecular mass:
    46276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB12 Gene

Proteomics data for SERPINB12 Gene at MOPED

Post-translational modifications for SERPINB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SERPINB12 Gene

Domains & Families for SERPINB12 Gene

Gene Families for SERPINB12 Gene

Protein Domains for SERPINB12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P63

UniProtKB/Swiss-Prot:

SPB12_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB12: view

Function for SERPINB12 Gene

Molecular function for SERPINB12 Gene

UniProtKB/Swiss-Prot Function:
Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.
genes like me logo Genes that share phenotypes with SERPINB12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINB12

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB12 Gene

Localization for SERPINB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB12 Gene COMPARTMENTS Subcellular localization image for SERPINB12 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11604408
genes like me logo Genes that share ontologies with SERPINB12: view

Pathways & Interactions for SERPINB12 Gene

SuperPathways for SERPINB12 Gene

No Data Available

Interacting Proteins for SERPINB12 Gene

Gene Ontology (GO) - Biological Process for SERPINB12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERPINB12 Gene

Drugs & Compounds for SERPINB12 Gene

No Compound Related Data Available

Transcripts for SERPINB12 Gene

mRNA/cDNA for SERPINB12 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB12 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB12 Gene

No ASD Table

Relevant External Links for SERPINB12 Gene

GeneLoc Exon Structure for
SERPINB12
ECgene alternative splicing isoforms for
SERPINB12

Expression for SERPINB12 Gene

mRNA expression in normal human tissues for SERPINB12 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB12 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.7), Skin - Sun Exposed (Lower leg) (x14.5), Vagina (x13.8), and Cervix - Ectocervix (x8.5).

Protein differential expression in normal tissues from HIPED for SERPINB12 Gene

This gene is overexpressed in Cerebrospinal fluid (18.5) and Urine (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB12 Gene



SOURCE GeneReport for Unigene cluster for SERPINB12 Gene Hs.348541

mRNA Expression by UniProt/SwissProt for SERPINB12 Gene

Q96P63-SPB12_HUMAN
Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.
genes like me logo Genes that share expression patterns with SERPINB12: view

Protein tissue co-expression partners for SERPINB12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINB12 Gene

Orthologs for SERPINB12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB12 36
  • 95 (a)
OneToOne
SERPINB12 35
  • 99.34 (n)
  • 99.51 (a)
cow
(Bos Taurus)
Mammalia SERPINB12 36
  • 73 (a)
OneToOne
SERPINB13 35
  • 82.55 (n)
  • 80 (a)
dog
(Canis familiaris)
Mammalia SERPINB12 35
  • 85.19 (n)
  • 82.47 (a)
SERPINB12 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb12 16
Serpinb12 35
  • 78.68 (n)
  • 72.84 (a)
Serpinb12 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINB12 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb12 35
  • 79.01 (n)
  • 73.09 (a)
chicken
(Gallus gallus)
Aves SERPINB12 35
  • 58.04 (n)
  • 48.73 (a)
-- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6687 37
  • 26 (a)
CG6717 37
  • 28 (a)
CG7722 37
  • 28 (a)
Spn2 37
  • 33 (a)
Spn3 37
  • 31 (a)
Species with no ortholog for SERPINB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB12 Gene

ENSEMBL:
Gene Tree for SERPINB12 (if available)
TreeFam:
Gene Tree for SERPINB12 (if available)

Paralogs for SERPINB12 Gene

genes like me logo Genes that share paralogs with SERPINB12: view

Variants for SERPINB12 Gene

Sequence variations from dbSNP and Humsavar for SERPINB12 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35582068 - 63,565,478(+) CGCAA(A/G)AAGGC reference, missense
rs35352345 - 63,566,659(+) AGAAA(A/C)CATGT reference, missense
rs11664907 - 63,566,806(+) TCCCA(A/G)TTTGT reference, missense
rs749545 -- 63,566,579(-) TTTAG(C/T)ATCAG intron-variant
rs964492 -- 63,552,524(-) ATTAT(G/T)CTAAT intron-variant

Variation tolerance for SERPINB12 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB12 Gene

HapMap Linkage Disequilibrium report
SERPINB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SERPINB12 Gene

Disorders for SERPINB12 Gene

Relevant External Links for SERPINB12

Genetic Association Database (GAD)
SERPINB12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB12

No disorders were found for SERPINB12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB12 Gene

Publications for SERPINB12 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  3. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SERPINB12 Gene

Sources for SERPINB12 Gene

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