SERPINB12 Gene
protein-coding GIFtS: 46
GCID: GC18P061196
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serpin peptidase inhibitor, clade B (ovalbumin), member...(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
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Aliases
for SERPINB12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 121 2 | | YUKOPIN1 2 | | Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 121 2 | | Serpin B122 |
Export aliases for SERPINB12 gene to outside databasesPrevious GC identifers: GC18P061062 GC18P059372 GC18P059374 GC18P057923 |
Summaries
for SERPINB12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63Function: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogenactivator
|
Genomic Views
for SERPINB12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERPINB12 gene promoter:
Brachyury STAT5A C/EBPalpha CHOP-10 PPAR-gamma1 CBF-B CBF-A PPAR-gamma2 Pax-4a CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERPINB12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.33SERPINB12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P061196: view genomic region
(about GC identifiers)
Start:
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61,223,393 bp from pter |
End:
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61,234,244 bp from pter |
Size:
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10,852 bases |
Orientation:
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plus strand |
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Proteins
for SERPINB12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63 (See
protein sequence)Recommended Name: Serpin B12 Size: 405 amino acids; 46276 Da
Subcellular location: Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for SERPINB12: NX_Q96P63
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96P63
SERPINB12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_536722.1
ENSEMBL proteins: ENSP00000269491 ENSP00000372218
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SERPINB12 for ontologies About GeneDecksing
SERPINB12 Antibody Products:
Assay Products for SERPINB12: |
Protein
Domains /
Families
for SERPINB12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERPINB12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96P63ProtoNet protein and cluster: Q96P63 1 Blocks protein family: IPB000215 Serpin
UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63Similarity: Belongs to the serpin family. Ov-serpin subfamily |
Function
for SERPINB12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63Function: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogenactivator
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERPINB12 (NM_080474) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINB12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SERPINB12 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SERPINB12:
|
Pathways & Interactions
for SERPINB12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINB12
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/22 Interacting proteins for SERPINB12 (Q96P633 ENSP000002694914) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0010951 | negative regulation of endopeptidase activity |
IBA | -- | | GO:0030162 | regulation of proteolysis |
IBA | -- | | GO:0042177 | negative regulation of protein catabolic process |
NAS | 11604408 |
SERPINB12 for ontologies About GeneDecksing
|
Drugs & Compounds
for SERPINB12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERPINB12
Search CenterWatch for drugs/clinical trials and news about SERPINB12 / SPB12
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Transcripts
for SERPINB12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERPINB12 gene: NM_080474.1 Unigene Cluster for SERPINB12: Serpin peptidase inhibitor, clade B (ovalbumin), member 12 Hs.348541 [show with all ESTs]Unigene Representative Sequence: AK3097542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269491(uc010xen.2) ENST00000382768(uc010xeo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERPINB12 (NM_080474) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINB12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB12 |
Additional cDNA sequence: AF411191.1 AK309754.1 BC103884.1 BC103885.1 2 DOTS entries: DT.40114024 DT.95152559 8 AceView cDNA sequences: NM_080474 AF411191 BX090362 AA242834 W74427 BG677045 W79181 AA242969
GeneLoc Exon Structure
|
Expression
for SERPINB12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERPINB12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATTACGG
About this image
See SERPINB12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINB12
SOURCE GeneReport for Unigene cluster: Hs.348541
UniProtKB/Swiss-Prot: SPB12_HUMAN, Q96P63Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas,testis, ovary, and intestine
SABiosciences Custom PCR Arrays for SERPINB12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB12 |
Orthologs
for SERPINB12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SERPINB12 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for SERPINB12 (if available)
TreeFam Gene Tree for SERPINB12 (if available) |
Paralogs
for SERPINB12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERPINB12 gene
- SERPINB72 SERPINB12 SERPINI12 SERPINB52 SERPINI22 SERPINB22 SERPINB102 SERPINB32
- SERPINB42 SERPINE22 SERPINB62 SERPINC12 SERPINB92 SERPINE12 SERPINE32 SERPINB132
- SERPINB82
18/38 SIMAP similar genes for SERPINB12 using alignment to 3 protein entries: SPB12_HUMAN (see all proteins)
(see all similar genes):SCCA1 AT3 PLANH2 DKFZp686O07189 SERPINB11 DKFZp686D06190
SERPINB6 SERPINB10 SERPINB3 SERPINB8 SERPINB1 SCCA2
SERPINB4 SERPINB9 SERPINB13 SERPINB2 SERPINB7 SERPINB5
SERPINB12 for paralogs About GeneDecksing
|
Genomic Variants
for SERPINB12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERPINB12 (61223393 - 61234244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERPINB12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB12 |
|
Disorders
/ Diseases
for SERPINB12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SERPINB12 for disorders About GeneDecksing
2  diseases for SERPINB12: About MalaCardshepatocellular carcinoma carcinoma
Export disorders for SERPINB12 gene to outside databases
|
Publications
for SERPINB12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERPINB12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERPINB12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. (PubMed id 11604408)1, 2 Askew Y.S.... Silverman G.A. (2001)
- The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Analysis of vertebrate genomes suggests a new model for clade B serpin evolution. (PubMed id 16305753)9 Kaiserman D. and Bird P.I. (2005)
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External Searches for SERPINB12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SERPINB12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERPINB12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERPINB12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERPINB12 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SERPINB12 gene:
Search GeneIP for patents involving SERPINB12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERPINB12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERPINB12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB12 | | | OriGene Protein Over-expression Lysate for SERPINB12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERPINB12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERPINB12 | | OriGene Custom Protein Services for SERPINB12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB12 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB12 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB12 |
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