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Aliases for SERPINB12 Gene

Aliases for SERPINB12 Gene

  • Serpin Family B Member 12 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12 2 3
  • Serpin B12 3
  • YUKOPIN 3

External Ids for SERPINB12 Gene

Previous GeneCards Identifiers for SERPINB12 Gene

  • GC18P061062
  • GC18P061196
  • GC18P059372
  • GC18P059374
  • GC18P057923

Summaries for SERPINB12 Gene

GeneCards Summary for SERPINB12 Gene

SERPINB12 (Serpin Family B Member 12) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include enzyme binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB3.

UniProtKB/Swiss-Prot for SERPINB12 Gene

  • Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB12 Gene

Genomics for SERPINB12 Gene

Regulatory Elements for SERPINB12 Gene

Enhancers for SERPINB12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F063584 1.1 Ensembl ENCODE 10.7 +67.1 67099 3.2 KLF1 ZNF316 MAFK SERPINB11 SERPINB12 SERPINB13
GH18F063484 0.2 ENCODE 10.1 -34.9 -34894 0.1 SERPINB12 SERPINB5 ENSG00000269989
GH18F063483 0.9 ENCODE 10 -35.5 -35548 0.2 SERPINB12 ENSG00000269989 SERPINB5
GH18F063105 1.5 FANTOM5 Ensembl ENCODE 8.4 -412.5 -412515 1.6 PKNOX1 TBL1XR1 WRNIP1 INSM2 BMI1 FEZF1 EBF1 RELA SCRT2 EED SERPINB12 LOC105372161 PIR61307
GH18F063552 1 Ensembl ENCODE 6.3 +34.2 34152 1.6 NFE2 EBF1 SERPINB5 SERPINB12 SERPINB13
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERPINB12 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB12 Gene

Chromosome:
18
Start:
63,519,090 bp from pter
End:
63,569,329 bp from pter
Size:
50,240 bases
Orientation:
Plus strand

Genomic View for SERPINB12 Gene

Genes around SERPINB12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB12 Gene

Proteins for SERPINB12 Gene

  • Protein details for SERPINB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P63-SPB12_HUMAN
    Recommended name:
    Serpin B12
    Protein Accession:
    Q96P63
    Secondary Accessions:
    • Q3SYB4

    Protein attributes for SERPINB12 Gene

    Size:
    405 amino acids
    Molecular mass:
    46276 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB12 Gene

Post-translational modifications for SERPINB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB12 Gene

No data available for DME Specific Peptides for SERPINB12 Gene

Domains & Families for SERPINB12 Gene

Gene Families for SERPINB12 Gene

Protein Domains for SERPINB12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P63

UniProtKB/Swiss-Prot:

SPB12_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB12: view

Function for SERPINB12 Gene

Molecular function for SERPINB12 Gene

UniProtKB/Swiss-Prot Function:
Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

Gene Ontology (GO) - Molecular Function for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IMP 11604408
GO:0019899 enzyme binding NAS 11604408
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB12: view
genes like me logo Genes that share phenotypes with SERPINB12: view

Animal Models for SERPINB12 Gene

MGI Knock Outs for SERPINB12:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINB12

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB12 Gene

Localization for SERPINB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB12 Gene COMPARTMENTS Subcellular localization image for SERPINB12 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm NAS 11604408
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERPINB12: view

Pathways & Interactions for SERPINB12 Gene

SuperPathways for SERPINB12 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with SERPINB12: view

Pathways by source for SERPINB12 Gene

2 Reactome pathways for SERPINB12 Gene

Gene Ontology (GO) - Biological Process for SERPINB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042177 negative regulation of protein catabolic process NAS 11604408
genes like me logo Genes that share ontologies with SERPINB12: view

No data available for SIGNOR curated interactions for SERPINB12 Gene

Transcripts for SERPINB12 Gene

mRNA/cDNA for SERPINB12 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB12 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB12 Gene

No ASD Table

Relevant External Links for SERPINB12 Gene

GeneLoc Exon Structure for
SERPINB12
ECgene alternative splicing isoforms for
SERPINB12

Expression for SERPINB12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINB12 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINB12 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.7), Skin - Sun Exposed (Lower leg) (x14.5), Vagina (x13.8), and Cervix - Ectocervix (x8.5).

Protein differential expression in normal tissues from HIPED for SERPINB12 Gene

This gene is overexpressed in Cerebrospinal fluid (18.5) and Urine (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB12 Gene



Protein tissue co-expression partners for SERPINB12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB12 Gene:

SERPINB12

SOURCE GeneReport for Unigene cluster for SERPINB12 Gene:

Hs.348541

mRNA Expression by UniProt/SwissProt for SERPINB12 Gene:

Q96P63-SPB12_HUMAN
Tissue specificity: Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.
genes like me logo Genes that share expression patterns with SERPINB12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINB12 Gene

Orthologs for SERPINB12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB12 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia SERPINB12 34 35
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia SERPINB13 34
  • 82.55 (n)
SERPINB12 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb12 34
  • 79.01 (n)
mouse
(Mus musculus)
Mammalia Serpinb12 34 16 35
  • 78.68 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINB12 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINB12 34
  • 58.04 (n)
-- 35
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn2 36
  • 33 (a)
Spn3 36
  • 31 (a)
CG6717 36
  • 28 (a)
CG7722 36
  • 28 (a)
CG6687 36
  • 26 (a)
Species where no ortholog for SERPINB12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINB12 Gene

ENSEMBL:
Gene Tree for SERPINB12 (if available)
TreeFam:
Gene Tree for SERPINB12 (if available)

Paralogs for SERPINB12 Gene

Variants for SERPINB12 Gene

Sequence variations from dbSNP and Humsavar for SERPINB12 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10460160 -- 63,534,249(+) GCTAG(C/T)AGCAA intron-variant
rs10469141 -- 63,555,841(+) TTGGA(C/T)GTTTG intron-variant, upstream-variant-2KB
rs10503081 -- 63,530,560(+) AAACA(A/G)TAGAT intron-variant
rs10503082 -- 63,533,580(+) AACAT(A/G)TTAAT intron-variant
rs1111283 -- 63,556,063(-) CATAC(C/T)TGAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINB12 Gene

Variant ID Type Subtype PubMed ID
esv3642773 CNV loss 21293372
nsv1066552 CNV gain 25217958

Variation tolerance for SERPINB12 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB12 Gene

Disorders for SERPINB12 Gene

Relevant External Links for SERPINB12

Genetic Association Database (GAD)
SERPINB12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB12

No disorders were found for SERPINB12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB12 Gene

Publications for SERPINB12 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  2. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. (PMID: 11604408) Askew Y.S. … Silverman G.A. (J. Biol. Chem. 2001) 3 4 64
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  4. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. (PMID: 26220980) Niehaus J.Z. … Luke C.J. (J. Histochem. Cytochem. 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for SERPINB12 Gene

Sources for SERPINB12 Gene

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