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SERPINB11 Gene

protein-coding   GIFtS: 49
GCID: GC18P061350

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11
(Gene/Pseudogene)1 2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 111 2
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 111
EPIPIN2
SERPIN112
Serpin B112

External Ids:    HGNC: 142211   Entrez Gene: 897782   Ensembl: ENSG000002060727   OMIM: 6156825   UniProtKB: Q96P153   
ORGUL members:         

Export aliases for SERPINB11 gene to outside databases

Previous GC identifers: GC18P061216 GC18P059526 GC18P059528 GC18P058071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINB11 Gene:
SERPINB11 (serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)) is a protein-coding gene. Diseases associated with SERPINB11 include edwards syndrome, and tonsillitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB11_HUMAN, Q96P15
Function: Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing
conformational change




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB11 gene promoter:
         GATA-3   AML1a   Brachyury   AP-4   GATA-1   GATA-2   PPAR-gamma1   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB11 promoter sequence
   Search Chromatin IP Primers for SERPINB11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

SERPINB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB11 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061350:  view genomic region     (about GC identifiers)

Start:
61,314,813 bp from pter      End:
61,391,127 bp from pter
Size:
76,315 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPB11_HUMAN, Q96P15 (See protein sequence)
Recommended Name: Serpin B11  
Size: 392 amino acids; 44099 Da
Caution: Mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead
of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory
activity
Secondary accessions: A8K9R0 Q5Q120 Q5Q121 Q5Q122 Q5Q123 Q6ISD3 Q96P13 Q96P14
Alternative splicing: 3 isoforms:  Q96P15-1   Q96P15-2   Q96P15-3   

Explore the universe of human proteins at neXtProt for SERPINB11: NX_Q96P15

Explore proteomics data for SERPINB11 at MOPED


See SERPINB11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001278207.1  NP_001278208.1  NP_536723.2  

ENSEMBL proteins: 
 ENSP00000421854   ENSP00000441497   ENSP00000440795   ENSP00000441708  

SERPINB11 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for SERPINB11


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SERPIN: Serine (or cysteine) peptidase inhibitors

3 InterPro protein domains:
 IPR023795 Serpin_CS
 IPR000215 Serpin_fam
 IPR023796 Serpin_dom

Graphical View of Domain Structure for InterPro Entry Q96P15

ProtoNet protein and cluster: Q96P15

1 Blocks protein domain: IPB000215 Serpin

UniProtKB/Swiss-Prot: SPB11_HUMAN, Q96P15
Similarity: Belongs to the serpin family. Ov-serpin subfamily


SERPINB11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPB11_HUMAN, Q96P15
Function: Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing
conformational change

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IBA--
     
SERPINB11 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB11
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB11

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SERPINB11

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OriGene ORF clones in mouse, rat for SERPINB11
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GenScript: all cDNA clones in your preferred vector: SERPINB11 (NM_080475)
Sino Biological Human cDNA Clone for SERPINB11
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB11

Cell Line
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SPB11_HUMAN, Q96P15: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
endoplasmic reticulum1
extracellular1
mitochondrion1
nucleus1
peroxisome1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005737cytoplasm IEA--

SERPINB11 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINB11
Interactions:

    Search GeneGlobe Interaction Network for SERPINB11

1 Interacting protein for SERPINB11 (Q96P153) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
POLR2CP193873I2D: score=4 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010951negative regulation of endopeptidase activity IBA--
GO:0030162regulation of proteolysis IBA--

SERPINB11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SERPINB11 (SPB11)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SERPINB11 gene (3 alternative transcripts): 
NM_001291278.1  NM_001291279.1  NM_080475.3  

Unigene Cluster for SERPINB11:

Serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
Hs.350958  [show with all ESTs]
Unigene Representative Sequence: AY739645
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489748 ENST00000382749(uc002ljk.4 uc010xes.2 uc010dqd.3)
ENST00000467649 ENST00000544088(uc002ljj.4 uc010dqe.3) ENST00000538847(uc010dqf.3)
ENST00000536691
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidSERPINB11 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB11
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERPINB11
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  QuantiFast Probe-based Assays in human, mouse, rat SERPINB11

Additional mRNA sequence: 

AF419953.1 AF419954.1 AF419955.1 AK292775.1 AK296705.1 AK309537.1 AK309970.1 AY739645.1 
AY792323.1 AY792324.1 AY792325.1 AY792326.1 BC069596.1 BC130370.1 BC130372.1 

5 DOTS entries:

DT.97831959  DT.121088260  DT.121088247  DT.121088239  DT.75187669 

9 AceView cDNA sequences:

AF419955 BE856469 AI391500 NM_080475 AF419954 BC069596 BX115281 AF419953 
BF676407 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SERPINB11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGGAAAGAG
SERPINB11 Expression
About this image


SERPINB11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Hair (Integumentary System)
         Bulge Stem Cells Bulge
 
 Epidermis (Integumentary System)
SERPINB11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SERPINB11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.350958

UniProtKB/Swiss-Prot: SPB11_HUMAN, Q96P15
Tissue specificity: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SERPINB11 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Serpinb111 , 5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1, 5 75.95(n)1
67.27(a)1
  1 (50.34 cM)5
669571  NM_025867.21  NP_080143.11 
 1073619295 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
45(a)
1 → many
2(67823487-67830028)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
47(a)
1 → many
GL343247.1(1897189-1916224)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004904871 leukocyte elastase inhibitor-like 55.47(n)
45.31(a)
  100490487  XM_002936420.2  XP_002936466.1 


ENSEMBL Gene Tree for SERPINB11 (if available)
TreeFam Gene Tree for SERPINB11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SERPINB11 gene
SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  
SERPINB32  SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  
SERPINB132  SERPINB82  
Selected SIMAP similar genes for SERPINB11 using alignment to 4 protein entries:     SPB11_HUMAN (see all proteins) (see all similar genes):
SCCA1    AT3    SERPINB12    DKFZp686D06190    SERPINB3    DKFZp686O07189
SERPINB13    SERPINB7    SERPINB10    SERPINB6    SERPINB4    SERPINB1
SERPINI1    SERPINB8    SCCA2    SERPINB2    PLANH2    SERPINB9

SERPINB11 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
SPB11_HUMAN, Q96P15: According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that
could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a,
SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon
in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed
here corresponds to SERPINB11a


Selected SNPs for SERPINB11 (see all 607)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435208411,2
C--61368344(+) TTTGAG/TGGTAA 1 -- us2k10--------
rs1839415451,2
--61368451(+) TACAAC/TCTAGA 1 -- us2k10--------
rs1162028531,2
C,F--61368814(+) TAGAAC/TGGTTT 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs1467545441,2
C--61368821(+) GTTTAC/GTTTCA 1 -- us2k10--------
rs14032991,2
C,F,A,H--61368825(+) AGTTTC/GAACTA 1 -- us2k116Minor allele frequency- G:0.45NS EA NA WA 1064
rs1894525911,2
--61368868(+) GAAAAC/TCACTG 1 -- us2k10--------
rs1401377931,2
--61368984(+) GTCTTC/TGAGAA 1 -- us2k10--------
rs80837941,2
C,F,A,H--61369142(+) GGCTTC/GTTGCT 1 -- us2k120Minor allele frequency- N:0.00EA NA NS WA 1418
rs1502973511,2
--61369146(+) TCTTGC/TTCCCA 1 -- us2k10--------
rs177782971,2
C,F,H--61369156(+) ACCAAG/ACTTTT 1 -- us2k123Minor allele frequency- A:0.06NA NS EA WA 2900

HapMap Linkage Disequilibrium report for SERPINB11 (61314813 - 61391127 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SERPINB11:    About this table    
Variant IDTypeSubtypePubMed ID
esv21739CNV Gain19812545
nsv833672CNV Gain17160897

Human Gene Mutation Database (HGMD): SERPINB11
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SERPINB11
DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615682    OMIM disorders: --

3 diseases for SERPINB11:    
About MalaCards
edwards syndrome    tonsillitis    prostatitis

1 disease from the University of Copenhagen DISEASES database for SERPINB11:
Endometrioid ovary carcinoma

SERPINB11 for disorders           About GeneDecksing

Genetic Association Database (GAD): SERPINB11

Export disorders for SERPINB11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SERPINB11 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with SERPINB11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. (PubMed id 17562709)1, 2, 3 Askew D.J.... Silverman G.A. (J. Biol. Chem. 2007)
  2. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens. (PubMed id 22289513)1 Lim W....Song G. (Exp. Biol. Med. (Maywood) 2012)
  5. Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions. (PubMed id 22393410)1 Seixas S....Victor B.L. (PLoS ONE 2012)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
  8. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (Genome Res. 2007)
  9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89778 HGNC: 14221 AceView: SERPINB11 Ensembl:ENSG00000206072 euGenes: HUgn89778
ECgene: SERPINB11 H-InvDB: SERPINB11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SERPINB11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SERPINB11 gene:
Search GeneIP for patents involving SERPINB11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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