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Aliases for SERPINB11 Gene

Aliases for SERPINB11 Gene

  • Serpin Family B Member 11 (Gene/Pseudogene) 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 (Gene/Pseudogene) 2
  • Serpin B11 3
  • SERPIN11 3
  • EPIPIN 3

External Ids for SERPINB11 Gene

Previous GeneCards Identifiers for SERPINB11 Gene

  • GC18P061216
  • GC18P061350
  • GC18P059526
  • GC18P059528
  • GC18P058071

Summaries for SERPINB11 Gene

GeneCards Summary for SERPINB11 Gene

SERPINB11 (Serpin Family B Member 11 (Gene/Pseudogene)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot for SERPINB11 Gene

  • Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Additional gene information for SERPINB11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB11 Gene

Genomics for SERPINB11 Gene

GeneHancer (GH) Regulatory Elements for SERPINB11 Gene

Promoters and enhancers for SERPINB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I063703 Promoter 0.5 EPDnew 590.3 +54.7 54709 0.1 SERPINB11 GC18P063715 GC18P063716 SERPINB3
GH18I063702 Promoter 0.5 EPDnew 583.1 +55.4 55362 0.1 SERPINB11 GC18P063715 GC18P063716 SERPINB3
GH18I063584 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 26.1 -61.3 -61344 3.1 MAFF KLF1 MAFK SERPINB13 SERPINB11 SERPINB12
GH18I063518 Enhancer 0.8 FANTOM5 ENCODE 20.8 -129.0 -128952 0.2 CTCF ZNF654 TRIM22 REST RAD21 ZSCAN5C SMC3 ZNF143 MIXL1 SERPINB12 SERPINB11 SERPINB5 KDSR GC18P063498
GH18I063708 Enhancer 0.4 ENCODE 36.4 +61.4 61402 0.7 JUN FOS SERPINB11 GC18P063716 GC18P063715 SERPINB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINB11 gene promoter:

Genomic Locations for SERPINB11 Gene

Genomic Locations for SERPINB11 Gene
chr18:63,647,579-63,726,432
(GRCh38/hg38)
Size:
78,854 bases
Orientation:
Plus strand
chr18:61,314,813-61,391,127
(GRCh37/hg19)

Genomic View for SERPINB11 Gene

Genes around SERPINB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB11 Gene

Proteins for SERPINB11 Gene

  • Protein details for SERPINB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P15-SPB11_HUMAN
    Recommended name:
    Serpin B11
    Protein Accession:
    Q96P15
    Secondary Accessions:
    • A8K9R0
    • Q5Q120
    • Q5Q121
    • Q5Q122
    • Q5Q123
    • Q6ISD3
    • Q96P13
    • Q96P14

    Protein attributes for SERPINB11 Gene

    Size:
    392 amino acids
    Molecular mass:
    44099 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB11 Gene

Post-translational modifications for SERPINB11 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SERPINB11 Gene

Domains & Families for SERPINB11 Gene

Gene Families for SERPINB11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SERPINB11 Gene

Suggested Antigen Peptide Sequences for SERPINB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P15

UniProtKB/Swiss-Prot:

SPB11_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB11: view

Function for SERPINB11 Gene

Molecular function for SERPINB11 Gene

UniProtKB/Swiss-Prot Function:
Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Phenotypes From GWAS Catalog for SERPINB11 Gene

Gene Ontology (GO) - Molecular Function for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB11: view
genes like me logo Genes that share phenotypes with SERPINB11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB11 Gene

Localization for SERPINB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB11 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA,IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SERPINB11: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SERPINB11 Gene

Pathways & Interactions for SERPINB11 Gene

SuperPathways for SERPINB11 Gene

No Data Available

Interacting Proteins for SERPINB11 Gene

Selected Interacting proteins: Q96P15-SPB11_HUMAN for SERPINB11 Gene via IID

Gene Ontology (GO) - Biological Process for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINB11: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINB11 Gene

Drugs & Compounds for SERPINB11 Gene

No Compound Related Data Available

Transcripts for SERPINB11 Gene

mRNA/cDNA for SERPINB11 Gene

Unigene Clusters for SERPINB11 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB11 Gene

No ASD Table

Relevant External Links for SERPINB11 Gene

GeneLoc Exon Structure for
SERPINB11
ECgene alternative splicing isoforms for
SERPINB11

Expression for SERPINB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINB11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB11 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.6), Vagina (x17.5), and Cervix - Ectocervix (x11.5).

Protein differential expression in normal tissues from HIPED for SERPINB11 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB11 Gene



Protein tissue co-expression partners for SERPINB11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINB11 Gene:

SERPINB11

SOURCE GeneReport for Unigene cluster for SERPINB11 Gene:

Hs.350958

mRNA Expression by UniProt/SwissProt for SERPINB11 Gene:

Q96P15-SPB11_HUMAN
Tissue specificity: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.
genes like me logo Genes that share expression patterns with SERPINB11: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINB11 Gene

Orthologs for SERPINB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB11 33
  • 98.3 (n)
dog
(Canis familiaris)
Mammalia SERPINB11 33 34
  • 86.82 (n)
rat
(Rattus norvegicus)
Mammalia Serpinb11 33
  • 76.03 (n)
mouse
(Mus musculus)
Mammalia Serpinb11 33 16 34
  • 75.95 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINB11 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB11 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490487 33
  • 55.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Spn1 35
  • 32 (a)
CG9455 35
  • 31 (a)
Spn3 35
  • 31 (a)
Spn5 35
  • 29 (a)
nec 35
  • 28 (a)
CG7722 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-7 35
  • 32 (a)
srp-6 35
  • 30 (a)
srp-1 35
  • 27 (a)
Species where no ortholog for SERPINB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB11 Gene

ENSEMBL:
Gene Tree for SERPINB11 (if available)
TreeFam:
Gene Tree for SERPINB11 (if available)

Paralogs for SERPINB11 Gene

Variants for SERPINB11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB11 Gene

SPB11_HUMAN-Q96P15
According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.

Sequence variations from dbSNP and Humsavar for SERPINB11 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000038489 -- 63,714,781(+) G/A intron_variant
rs1000085482 -- 63,714,539(+) A/C intron_variant
rs1000287802 -- 63,709,835(+) G/A intron_variant
rs1000392665 -- 63,704,256(+) A/G intron_variant
rs1000427959 -- 63,721,968(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINB11 Gene

Variant ID Type Subtype PubMed ID
dgv995e212 CNV loss 25503493
esv21739 CNV gain 19812545
esv3642781 CNV gain 21293372
nsv1066552 CNV gain 25217958
nsv833672 CNV gain 17160897

Additional Variant Information for SERPINB11 Gene

Human Gene Mutation Database (HGMD)
SERPINB11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINB11

No data available for Variation tolerance for SERPINB11 Gene

Disorders for SERPINB11 Gene

Additional Disease Information for SERPINB11

No disorders were found for SERPINB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB11 Gene

Publications for SERPINB11 Gene

  1. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. (PMID: 17562709) Askew DJ … Silverman GA (The Journal of biological chemistry 2007) 2 3 4 58
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SERPINB11 Gene

Sources for SERPINB11 Gene

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