Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINB11 Gene

Aliases for SERPINB11 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 (Gene/Pseudogene) 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2
  • Serpin B11 3
  • SERPIN11 3
  • EPIPIN 3

External Ids for SERPINB11 Gene

Previous GeneCards Identifiers for SERPINB11 Gene

  • GC18P061216
  • GC18P061350
  • GC18P059526
  • GC18P059528
  • GC18P058071

Summaries for SERPINB11 Gene

GeneCards Summary for SERPINB11 Gene

SERPINB11 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB11 Gene

  • Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB11 Gene

Genomics for SERPINB11 Gene

Regulatory Elements for SERPINB11 Gene

Genomic Location for SERPINB11 Gene

Start:
63,647,579 bp from pter
End:
63,726,432 bp from pter
Size:
78,854 bases
Orientation:
Plus strand

Genomic View for SERPINB11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB11 Gene

Proteins for SERPINB11 Gene

  • Protein details for SERPINB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P15-SPB11_HUMAN
    Recommended name:
    Serpin B11
    Protein Accession:
    Q96P15
    Secondary Accessions:
    • A8K9R0
    • Q5Q120
    • Q5Q121
    • Q5Q122
    • Q5Q123
    • Q6ISD3
    • Q96P13
    • Q96P14

    Protein attributes for SERPINB11 Gene

    Size:
    392 amino acids
    Molecular mass:
    44099 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB11 Gene

Proteomics data for SERPINB11 Gene at MOPED

Post-translational modifications for SERPINB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB11 Gene

No data available for DME Specific Peptides for SERPINB11 Gene

Domains for SERPINB11 Gene

Gene Families for SERPINB11 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P15

UniProtKB/Swiss-Prot:

SPB11_HUMAN :
  • Q96P15
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB11: view

Function for SERPINB11 Gene

Molecular function for SERPINB11 Gene

UniProtKB/Swiss-Prot Function: Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Gene Ontology (GO) - Molecular Function for SERPINB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with SERPINB11: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINB11
    • Block miRNA regulation of SERPINB11 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB11

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB11 Gene

    Localization for SERPINB11 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for SERPINB11 Gene

    Cytoplasm.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for SERPINB11 Gene COMPARTMENTS Subcellular localization image for SERPINB11 gene
    Compartment Confidence
    cytosol 2
    endoplasmic reticulum 1
    extracellular 1
    mitochondrion 1
    nucleus 1
    peroxisome 1
    plasma membrane 1

    Gene Ontology (GO) - Cellular Components for SERPINB11 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005615 extracellular space IBA --
    GO:0005737 cytoplasm IEA --
    genes like me logo Genes that share ontologies with SERPINB11: view

    Pathways for SERPINB11 Gene

    SuperPathways for SERPINB11 Gene

    No Data Available

    Interacting Proteins for SERPINB11 Gene

    Selected Interacting proteins: Q96P15-SPB11_HUMAN for SERPINB11 Gene via I2D

    Symbol External ID(s) Details
    POLR2C

    Gene Ontology (GO) - Biological Process for SERPINB11 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0010951 negative regulation of endopeptidase activity IBA --
    GO:0030162 regulation of proteolysis --
    genes like me logo Genes that share ontologies with SERPINB11: view

    No data available for Pathways by source for SERPINB11 Gene

    Transcripts for SERPINB11 Gene

    mRNA/cDNA for SERPINB11 Gene

    Unigene Clusters for SERPINB11 Gene

    Serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene):
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINB11
      • Block miRNA regulation of SERPINB11 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB11

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SERPINB11
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB11 Gene

      No ASD Table

      Relevant External Links for SERPINB11 Gene

      GeneLoc Exon Structure for
      SERPINB11
      ECgene alternative splicing isoforms for
      SERPINB11

      Expression for SERPINB11 Gene

      mRNA expression in normal human tissues for SERPINB11 Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for SERPINB11 Gene

      This gene is overexpressed in Esophagus - Mucosa (17.6), Vagina (17.5), and Cervix - Ectocervix (11.5).

      Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SERPINB11 Gene

      SOURCE GeneReport for Unigene cluster for SERPINB11 Gene Hs.350958

      mRNA Expression by UniProt/SwissProt for SERPINB11 Gene

      Q96P15-SPB11_HUMAN
      Tissue specificity: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.
      genes like me logo Genes that share expressions with SERPINB11: view

      In Situ Assay Products

      Orthologs for SERPINB11 Gene

      This gene was present in the common ancestor of animals.

      Orthologs for SERPINB11 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia SERPINB11 35
      • 98.3 (n)
      • 97.19 (a)
      dog
      (Canis familiaris)
      Mammalia SERPINB11 35
      • 86.82 (n)
      • 81.89 (a)
      SERPINB11 36
      • 81 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Serpinb11 35
      • 75.95 (n)
      • 67.27 (a)
      Serpinb11 16
      Serpinb11 36
      • 67 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia SERPINB11 36
      • 67 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia SERPINB11 36
      • 59 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Serpinb11 35
      • 76.03 (n)
      • 69.07 (a)
      chicken
      (Gallus gallus)
      Aves -- 36
      • 45 (a)
      OneToMany
      lizard
      (Anolis carolinensis)
      Reptilia -- 36
      • 47 (a)
      OneToMany
      tropical clawed frog
      (Silurana tropicalis)
      Amphibia LOC100490487 35
      • 55.47 (n)
      • 45.31 (a)
      fruit fly
      (Drosophila melanogaster)
      Insecta Spn5 37
      • 29 (a)
      Spn3 37
      • 31 (a)
      CG9455 37
      • 31 (a)
      Spn1 37
      • 32 (a)
      nec 37
      • 28 (a)
      CG7722 37
      • 27 (a)
      worm
      (Caenorhabditis elegans)
      Secernentea srp-7 37
      • 32 (a)
      srp-1 37
      • 27 (a)
      srp-6 37
      • 30 (a)
      Species with no ortholog for SERPINB11:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • wheat (Triticum aestivum)
      • zebrafish (Danio rerio)

      Evolution for SERPINB11 Gene

      ENSEMBL:
      Gene Tree for SERPINB11 (if available)
      TreeFam:
      Gene Tree for SERPINB11 (if available)

      Paralogs for SERPINB11 Gene

      genes like me logo Genes that share paralogs with SERPINB11: view

      Variants for SERPINB11 Gene

      Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB11 Gene

      Q96P15-SPB11_HUMAN
      According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.

      Sequence variations from dbSNP and Humsavar for SERPINB11 Gene

      SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
      rs952857 -- 63,707,338(-) ACCTA(G/T)TCAGA intron-variant
      rs953694 -- 63,723,599(+) GTAGA(A/C/T)TTATG utr-variant-3-prime
      rs953695 -- 63,723,336(+) TTCCT(G/T)TTCTT synonymous-codon, reference
      rs953696 -- 63,723,415(+) TTGAG(C/T)AAGGC utr-variant-3-prime
      rs1010248 -- 63,719,160(-) GACAA(A/C)ACTAA intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for SERPINB11 Gene

      Variant ID Type Subtype PubMed ID
      nsv833672 CNV Gain 17160897
      esv21739 CNV Gain 19812545

      Relevant External Links for SERPINB11 Gene

      HapMap Linkage Disequilibrium report
      SERPINB11
      Human Gene Mutation Database (HGMD)
      SERPINB11

      Disorders for SERPINB11 Gene

      (1) University of Copenhagen DISEASES for SERPINB11 Gene

      Relevant External Links for SERPINB11

      Genetic Association Database (GAD)
      SERPINB11
      genes like me logo Genes that share disorders with SERPINB11: view

      No data available for UniProtKB/Swiss-Prot for SERPINB11 Gene

      Publications for SERPINB11 Gene

      1. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. (PMID: 17562709) Askew D.J. … Silverman G.A. (J. Biol. Chem. 2007) 2 3 4
      2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
      3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
      5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

      Products for SERPINB11 Gene

      Sources for SERPINB11 Gene

      Back to Top

      Content