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Aliases for SERPINB11 Gene

Aliases for SERPINB11 Gene

  • Serpin Family B Member 11 (Gene/Pseudogene) 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 (Gene/Pseudogene) 2 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2 3
  • SERPIN11 3
  • EPIPIN 3

External Ids for SERPINB11 Gene

Previous GeneCards Identifiers for SERPINB11 Gene

  • GC18P061216
  • GC18P061350
  • GC18P059526
  • GC18P059528
  • GC18P058071

Summaries for SERPINB11 Gene

GeneCards Summary for SERPINB11 Gene

SERPINB11 (Serpin Family B Member 11 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB11 Gene

  • Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB11 Gene

Genomics for SERPINB11 Gene

Regulatory Elements for SERPINB11 Gene

Genomic Location for SERPINB11 Gene

Chromosome:
18
Start:
63,647,579 bp from pter
End:
63,726,432 bp from pter
Size:
78,854 bases
Orientation:
Plus strand

Genomic View for SERPINB11 Gene

Genes around SERPINB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB11 Gene

Proteins for SERPINB11 Gene

  • Protein details for SERPINB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P15-SPB11_HUMAN
    Recommended name:
    Serpin B11
    Protein Accession:
    Q96P15
    Secondary Accessions:
    • A8K9R0
    • Q5Q120
    • Q5Q121
    • Q5Q122
    • Q5Q123
    • Q6ISD3
    • Q96P13
    • Q96P14

    Protein attributes for SERPINB11 Gene

    Size:
    392 amino acids
    Molecular mass:
    44099 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERPINB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB11 Gene

Proteomics data for SERPINB11 Gene at MOPED

Post-translational modifications for SERPINB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB11 Gene

No data available for DME Specific Peptides for SERPINB11 Gene

Domains & Families for SERPINB11 Gene

Gene Families for SERPINB11 Gene

Protein Domains for SERPINB11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P15

UniProtKB/Swiss-Prot:

SPB11_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB11: view

Function for SERPINB11 Gene

Molecular function for SERPINB11 Gene

UniProtKB/Swiss-Prot Function:
Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.
genes like me logo Genes that share phenotypes with SERPINB11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINB11 Gene

Localization for SERPINB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB11 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SERPINB11 Gene

Pathways & Interactions for SERPINB11 Gene

SuperPathways for SERPINB11 Gene

No Data Available

Interacting Proteins for SERPINB11 Gene

Selected Interacting proteins: Q96P15-SPB11_HUMAN for SERPINB11 Gene via I2D

Symbol External ID(s) Details
POLR2C

Gene Ontology (GO) - Biological Process for SERPINB11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERPINB11 Gene

Drugs & Compounds for SERPINB11 Gene

No Compound Related Data Available

Transcripts for SERPINB11 Gene

mRNA/cDNA for SERPINB11 Gene

Unigene Clusters for SERPINB11 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB11 Gene

No ASD Table

Relevant External Links for SERPINB11 Gene

GeneLoc Exon Structure for
SERPINB11
ECgene alternative splicing isoforms for
SERPINB11

Expression for SERPINB11 Gene

mRNA expression in normal human tissues for SERPINB11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB11 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.6), Vagina (x17.5), and Cervix - Ectocervix (x11.5).

Protein differential expression in normal tissues from HIPED for SERPINB11 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERPINB11 Gene



SOURCE GeneReport for Unigene cluster for SERPINB11 Gene Hs.350958

mRNA Expression by UniProt/SwissProt for SERPINB11 Gene

Q96P15-SPB11_HUMAN
Tissue specificity: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.
genes like me logo Genes that share expression patterns with SERPINB11: view

Protein tissue co-expression partners for SERPINB11 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SERPINB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SERPINB11 35
  • 86.82 (n)
  • 81.89 (a)
SERPINB11 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb11 35
  • 75.95 (n)
  • 67.27 (a)
Serpinb11 16
Serpinb11 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINB11 35
  • 98.3 (n)
  • 97.19 (a)
rat
(Rattus norvegicus)
Mammalia Serpinb11 35
  • 76.03 (n)
  • 69.07 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINB11 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB11 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490487 35
  • 55.47 (n)
  • 45.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7722 37
  • 27 (a)
CG9455 37
  • 31 (a)
nec 37
  • 28 (a)
Spn1 37
  • 32 (a)
Spn3 37
  • 31 (a)
Spn5 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-1 37
  • 27 (a)
srp-6 37
  • 30 (a)
srp-7 37
  • 32 (a)
Species with no ortholog for SERPINB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB11 Gene

ENSEMBL:
Gene Tree for SERPINB11 (if available)
TreeFam:
Gene Tree for SERPINB11 (if available)

Paralogs for SERPINB11 Gene

genes like me logo Genes that share paralogs with SERPINB11: view

Variants for SERPINB11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB11 Gene

Q96P15-SPB11_HUMAN
According to some authors, 4 of the identified SERPIN11 transcripts contained coding sequences that could be distinguished by different combinations of single nucleotide polymorphisms (designated SERPINB11a, SERPINB11b, SERPINB11c, and SERPINB11d), and one contained a nonsense mutation introducing a premature stop codon in position 90 identified in the official genome sequence (SERPINB11f) (PubMed:17562709). The sequence displayed here corresponds to SERPINB11a.

Sequence variations from dbSNP and Humsavar for SERPINB11 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs17071550 - 63,716,120(+) GAAAA(C/T)GATTA intron-variant, reference, missense
VAR_012473 -
rs34811964 - 63,723,281(+) CAGCA(C/T)CGCTG reference, missense
rs1395268 - 63,710,345(+) GACTG(A/C)AGAGC reference, missense, utr-variant-5-prime
rs1506419 - 63,720,099(+) GACAA(A/T)GGCAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINB11 Gene

Variant ID Type Subtype PubMed ID
nsv833672 CNV Gain 17160897
esv21739 CNV Gain 19812545

Relevant External Links for SERPINB11 Gene

HapMap Linkage Disequilibrium report
SERPINB11
Human Gene Mutation Database (HGMD)
SERPINB11

No data available for Variation tolerance for SERPINB11 Gene

Disorders for SERPINB11 Gene

Relevant External Links for SERPINB11

Genetic Association Database (GAD)
SERPINB11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB11

No disorders were found for SERPINB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB11 Gene

Publications for SERPINB11 Gene

  1. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. (PMID: 17562709) Askew D.J. … Silverman G.A. (J. Biol. Chem. 2007) 2 3 4 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens. (PMID: 22289513) Lim W. … Song G. (Exp. Biol. Med. (Maywood) 2012) 3
  5. Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions. (PMID: 22393410) Seixas S. … Victor B.L. (PLoS ONE 2012) 3

Products for SERPINB11 Gene

Sources for SERPINB11 Gene

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