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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB10 Gene

protein-coding   GIFtS: 54
GCID: GC18P061556

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 101 2     Protease Inhibitor 10 (Ovalbumin Type1
PI101 2 3 5     bomapin2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 101 2     Protease Inhibitor 10 (Ovalbumin Type, Bomapin)2
Peptidase Inhibitor 102 3     Serpin B102
PI-102 3     Bomapin3
bomapin)1     

External Ids:    HGNC: 89421   Entrez Gene: 52732   Ensembl: ENSG000002425507   OMIM: 6020585   UniProtKB: P485953   

Export aliases for SERPINB10 gene to outside databases

Previous GC identifers: GC18P061421 GC18P061367 GC18P059731 GC18P059733 GC18P058283


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINB10 Gene:
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of
intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular
differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved
tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed
2690952)). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease
inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin
PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal
extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate
position (summary by Bartuski et al., 1997 (PubMed 9268635)).(supplied by OMIM, Jan 2010)

GeneCards Summary for SERPINB10 Gene: 
SERPINB10 (serpin peptidase inhibitor, clade B (ovalbumin), member 10) is a protein-coding gene. Diseases associated with SERPINB10 include edwards syndrome, and prostate cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB7.

UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis
and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB10 gene promoter:
         HNF-4alpha2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-4alpha1   AREB6   HFH-1   COMP1   IRF-7A   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB10 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061556:  view genomic region     (about GC identifiers)

Start:
61,564,408 bp from pter      End:
61,603,345 bp from pter
Size:
38,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595 (See protein sequence)
Recommended Name: Serpin B10  
Size: 397 amino acids; 45403 Da
Subcellular location: Nucleus. Cytoplasm. Note=Mostly found in the nucleus
Secondary accessions: Q4VAX4 Q4VAX7

Explore the universe of human proteins at neXtProt for SERPINB10: NX_P48595

Explore proteomics data for SERPINB10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48595

  • SERPINB10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB10 Protein Expression
    REFSEQ proteins: NP_005015.1  
    ENSEMBL proteins: 
     ENSP00000381082   ENSP00000392381   ENSP00000238508  

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    Sino Biological Recombinant Protein for SERPINB10
    Sino Biological Cell Lysate for SERPINB10 
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    Cloud-Clone Corp. Proteins for SERPINB10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SERPINB10 for ontologies           About GeneDecksing



    SERPINB10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P48595

    ProtoNet protein and cluster: P48595

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPB10_HUMAN, P48595
    Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis
    and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
         
    SERPINB10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SERPINB10:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB10 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis
    2Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SERPINB10
        Integrated Pancreatic Cancer Pathway



    1         Kegg Pathway  (Kegg details for SERPINB10):
        Amoebiasis


    SERPINB10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINB10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SERPINB10 (ENSP000002385084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSGENSP000002163364STRING: ENSP00000216336
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    SERPINB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB10 (SPB10)

    1 Novoseek inferred chemical compound relationship for SERPINB10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 51.5 2 10871600 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB10 / SPB10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB10 gene: 
    NM_005024.1  

    Unigene Cluster for SERPINB10:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 10
    Hs.158339  [show with all ESTs]
    Unigene Representative Sequence: AK314936
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397996(uc002ljp.1) ENST00000418725(uc002ljq.1) ENST00000238508(uc010xev.2 uc010xew.2)

    miRNA
    Products:
         
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB10
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    Primer
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    OriGene qPCR primer pairs and template standards for SERPINB10
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB10
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    Additional mRNA sequence: 

    AK314936.1 BC096217.3 BC096218.3 BC096219.3 BC096220.3 U35459.1 

    1 DOTS entry:

    DT.92024982 

    2 AceView cDNA sequences:

    NM_005024 U35459 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB10 expression in normal human tissues (normalized intensities)      SERPINB10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACATATT
    SERPINB10 Expression
    About this image


    SERPINB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Epidermis (Integumentary System)
             Stratified Epidermis
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Blood (Muscoskeletal System)
             bone marrow   
     
     Brain (Nervous System)

    See SERPINB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB10

    SOURCE GeneReport for Unigene cluster: Hs.158339

    UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
    Tissue specificity: Expressed specifically in myeloid cells and the bone marrow

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB10 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb101 , 5 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), more1, 5 80.39(n)1
    74.79(a)1
      1 (50.34 cM)5
    2411971  NM_198028.31  NP_932145.31 
     1075290275 
    chicken
    (Gallus gallus)
    Aves SERPINB101 serpin peptidase inhibitor, clade B (ovalbumin), member more 60.32(n)
    49.49(a)
      395715  NM_204897.1  NP_990228.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINB106
    --
    --
    57(a)
    48(a)
    1 ↔ 1
    possible ortholog
    GL343311.1(683935-700765)
    GL343311.1(703856-715609)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    serpinb16
    (see all 7)
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    (see all 7)
    47(a)
    46(a)
    (see all 7)
    possible ortholog
    many ↔ many
    (see all 7)
    16(54874440-54879870)
    20(26910467-26916434)


    ENSEMBL Gene Tree for SERPINB10 (if available)
    TreeFam Gene Tree for SERPINB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB10 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINB112  SERPINE32  
    SERPINB132  SERPINB82  
    18/36 SIMAP similar genes for SERPINB10 using alignment to 4 protein entries:     SPB10_HUMAN (see all proteins) (see all similar genes):
    SERPINB2    PLANH2    DKFZp686O07189    SERPINB13    DKFZp686D06190    SERPINB1
    SERPINB11    SERPINB8    SERPINB9    SERPINB12    SERPINB4    AT3
    SERPINB3    SERPINB6    SCCA2    SERPINB7    SERPINA1    SERPINB5

    SERPINB10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/613 SNPs in SERPINB10 are shown (see all 613)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154110961,2
    F--58281880(+) TCTGCG/AGTAAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs80860481,2
    C,F,A--61580828(+) ttcttG/Agcatt 1 -- us2k17Minor allele frequency- A:0.27WA NA CSA EA 366
    rs1918508561,2
    --61580831(+) TTGGCA/GTTGAT 1 -- us2k10--------
    rs1147092341,2
    F--61580876(+) GTTGGT/CACAAT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1416037631,2
    C--61580927(+) AGCAT-/GTAATC 1 -- us2k10--------
    rs1476454611,2
    --61580990(+) GATGGC/TTGGAG 1 -- us2k10--------
    rs65674051,2
    C,F,A--61581171(+) gtgctC/Gcaatg 1 -- us2k16Minor allele frequency- G:0.30NA WA CSA EA 246
    rs2013118501,2
    C--61581209(+) AAGTCA/TGTTAA 1 -- us2k10--------
    rs123264171,2
    C,F,H--61581241(+) ttttgC/Tcatta 1 -- us2k19Minor allele frequency- T:0.03NS EA NA WA 890
    rs1179111201,2
    C,F--61581325(+) CACTGC/TTCTAT 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SERPINB10 (61564408 - 61603345 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SERPINB10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525889CNV Loss19592680
    esv21739CNV Gain19812545
    nsv909693CNV Gain21882294
    nsv833673CNV Gain17160897
    essv7909CNV CNV17122850
    dgv1034e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602058    OMIM disorders: --

    6 diseases for SERPINB10:    About MalaCards
    edwards syndrome    prostate cancer    pancreatic cancer    prostatitis
    pancreatitis    leukemia


    SERPINB10 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SERPINB10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia myelomonocytic chronic 75.4 3 9454755 (1), 10871600 (1)
    necrosis 9.06 3 10871600 (2), 9454755 (1)
    tumors 8.26 3 10871600 (2), 9454755 (1)

    Genetic Association Database (GAD): SERPINB10
    Human Genome Epidemiology (HuGE) Navigator: SERPINB10 (1 document)

    Export disorders for SERPINB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB10 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SERPINB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. (PubMed id 10871600)1, 2, 3, 9 Schleef R.R. and Chuang T.L. (2000)
    2. Bomapin is a redox-sensitive nuclear serpin that affe cts responsiveness of myeloid progenitor cells to growth environment. (PubMed id 20433722)1, 2, 9 Przygodzka P....Wilczynska M. (2010)
    3. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. (PubMed id 10196205)1, 2, 9 Chuang T.L. and Schleef R.R. (1999)
    4. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. (PubMed id 7592909)1, 2, 9 Riewald M. and Schleef R.R. (1995)
    5. Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer. (PubMed id 16172807)1, 4, 9 Shioji G....Emi M. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PubMed id 9268635)1, 3 Bartuski A.J....Silverman G.A. (1997)
    8. Novel pancreatic beta cell-specific proteins: antibody -based proteomics for identification of new biomarker candidates. (PubMed id 22465717)1 Lindskog C....Danielsson A. (2012)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Implications of the three-dimensional structure of al pha 1-antitrypsin for structure and function of serpins. (PubMed id 2690952)1 Huber R. and Carrell R.W. (1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5273 HGNC: 8942 AceView: SERPINB10 Ensembl:ENSG00000242550 euGenes: HUgn5273
    ECgene: SERPINB10 Kegg: 5273 H-InvDB: SERPINB10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB10 gene:
    Search GeneIP for patents involving SERPINB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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