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Aliases for SERPINB10 Gene

Aliases for SERPINB10 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 10 2 3
  • PI10 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 10 2 3
  • Peptidase Inhibitor 10 3 4
  • Bomapin 3 4
  • PI-10 3 4
  • Protease Inhibitor 10 (Ovalbumin Type, Bomapin) 3
  • Protease Inhibitor 10 (Ovalbumin Type 2
  • Serpin B10 3
  • Bomapin) 2

External Ids for SERPINB10 Gene

Previous HGNC Symbols for SERPINB10 Gene

  • PI10

Previous GeneCards Identifiers for SERPINB10 Gene

  • GC18P061421
  • GC18P061556
  • GC18P061367
  • GC18P059731
  • GC18P059733
  • GC18P058283

Summaries for SERPINB10 Gene

Entrez Gene Summary for SERPINB10 Gene

  • The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

GeneCards Summary for SERPINB10 Gene

SERPINB10 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 10) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB10 Gene

  • Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB10 Gene

Genomics for SERPINB10 Gene

Regulatory Elements for SERPINB10 Gene

Genomic Location for SERPINB10 Gene

Start:
63,897,174 bp from pter
End:
63,936,111 bp from pter
Size:
38,938 bases
Orientation:
Plus strand

Genomic View for SERPINB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB10 Gene

Proteins for SERPINB10 Gene

  • Protein details for SERPINB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48595-SPB10_HUMAN
    Recommended name:
    Serpin B10
    Protein Accession:
    P48595
    Secondary Accessions:
    • Q4VAX4
    • Q4VAX7

    Protein attributes for SERPINB10 Gene

    Size:
    397 amino acids
    Molecular mass:
    45403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB10 Gene

Proteomics data for SERPINB10 Gene at MOPED

Post-translational modifications for SERPINB10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB10 Gene

No data available for DME Specific Peptides for SERPINB10 Gene

Domains for SERPINB10 Gene

Gene Families for SERPINB10 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB10 Gene

Graphical View of Domain Structure for InterPro Entry

P48595

UniProtKB/Swiss-Prot:

SPB10_HUMAN :
  • P48595
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB10: view

Function for SERPINB10 Gene

Molecular function for SERPINB10 Gene

UniProtKB/Swiss-Prot Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

Gene Ontology (GO) - Molecular Function for SERPINB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINB10: view

Phenotypes for SERPINB10 Gene

GenomeRNAi human phenotypes for SERPINB10:
genes like me logo Genes that share phenotypes with SERPINB10: view

Animal Model Products

CRISPR Products

miRNA for SERPINB10 Gene

miRTarBase miRNAs that target SERPINB10

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINB10
    • Block miRNA regulation of SERPINB10 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB10

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERPINB10 Gene

    Localization for SERPINB10 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for SERPINB10 Gene

    Nucleus. Cytoplasm. Note=Mostly found in the nucleus.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for SERPINB10 Gene COMPARTMENTS Subcellular localization image for SERPINB10 gene
    Compartment Confidence
    nucleus 5
    cytosol 3
    golgi apparatus 1

    Gene Ontology (GO) - Cellular Components for SERPINB10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005615 extracellular space IBA --
    GO:0005634 nucleus IEA --
    GO:0005737 cytoplasm IEA --
    genes like me logo Genes that share ontologies with SERPINB10: view

    Pathways for SERPINB10 Gene

    genes like me logo Genes that share pathways with SERPINB10: view

    Pathways by source for SERPINB10 Gene

    1 BioSystems pathway for SERPINB10 Gene
    1 KEGG pathway for SERPINB10 Gene

    Interacting Proteins for SERPINB10 Gene

    Gene Ontology (GO) - Biological Process for SERPINB10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0002230 positive regulation of defense response to virus by host IMP 22020285
    GO:0010951 negative regulation of endopeptidase activity IBA --
    GO:0030162 regulation of proteolysis --
    GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
    genes like me logo Genes that share ontologies with SERPINB10: view

    Compounds for SERPINB10 Gene

    (1) Novoseek inferred chemical compound relationships for SERPINB10 Gene

    Compound -log(P) Hits PubMed IDs
    serine 51.5 1
    genes like me logo Genes that share compounds with SERPINB10: view

    Transcripts for SERPINB10 Gene

    mRNA/cDNA for SERPINB10 Gene

    (6) Additional mRNA sequences :
    (4) REFSEQ mRNAs :
    (2) Selected AceView cDNA sequences:
    (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for SERPINB10 Gene

    Serpin peptidase inhibitor, clade B (ovalbumin), member 10:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINB10
      • Block miRNA regulation of SERPINB10 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINB10

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB10 Gene

      No ASD Table

      Relevant External Links for SERPINB10 Gene

      GeneLoc Exon Structure for
      SERPINB10
      ECgene alternative splicing isoforms for
      SERPINB10

      Expression for SERPINB10 Gene

      mRNA expression in normal human tissues for SERPINB10 Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for SERPINB10 Gene

      This gene is overexpressed in Whole Blood (21.6).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB10 Gene

      SOURCE GeneReport for Unigene cluster for SERPINB10 Gene Hs.158339

      mRNA Expression by UniProt/SwissProt for SERPINB10 Gene

      P48595-SPB10_HUMAN
      Tissue specificity: Expressed specifically in myeloid cells and the bone marrow.
      genes like me logo Genes that share expressions with SERPINB10: view

      In Situ Assay Products

      Orthologs for SERPINB10 Gene

      This gene was present in the common ancestor of animals.

      Orthologs for SERPINB10 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia SERPINB10 36
      • 98 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia SERPINB10 35
      • 85.98 (n)
      • 80.1 (a)
      SERPINB10 36
      • 80 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia SERPINB10 35
      • 84.89 (n)
      • 79.35 (a)
      SERPINB10 36
      • 79 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Serpinb10 35
      • 80.39 (n)
      • 74.79 (a)
      Serpinb10 16
      Serpinb10 36
      • 76 (a)
      OneToMany
      Serpinb10 36
      • 76 (a)
      OneToMany
      oppossum
      (Monodelphis domestica)
      Mammalia SERPINB10 36
      • 62 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Serpinb10 35
      • 79.51 (n)
      • 72.29 (a)
      chicken
      (Gallus gallus)
      Aves -- 36
      • 49 (a)
      OneToMany
      LOC101749622 35
      • 61.7 (n)
      • 51.77 (a)
      SERPINB10 36
      • 47 (a)
      OneToMany
      lizard
      (Anolis carolinensis)
      Reptilia SERPINB10 36
      • 59 (a)
      OneToOne
      zebrafish
      (Danio rerio)
      Actinopterygii serpinb1l1 36
      • 49 (a)
      ManyToMany
      serpinb1l3 36
      • 42 (a)
      ManyToMany
      serpinb1l4 36
      • 44 (a)
      ManyToMany
      si:ch73-303g23.4 36
      • 42 (a)
      ManyToMany
      zgc:173729 36
      • 43 (a)
      ManyToMany
      fruit fly
      (Drosophila melanogaster)
      Insecta Spn3 37
      • 31 (a)
      Spn2 37
      • 31 (a)
      Spn43Aa 37
      • 29 (a)
      CG9455 37
      • 32 (a)
      nec 37
      • 26 (a)
      Spn4 37
      • 34 (a)
      Species with no ortholog for SERPINB10:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for SERPINB10 Gene

      ENSEMBL:
      Gene Tree for SERPINB10 (if available)
      TreeFam:
      Gene Tree for SERPINB10 (if available)

      Paralogs for SERPINB10 Gene

      genes like me logo Genes that share paralogs with SERPINB10: view

      Variants for SERPINB10 Gene

      Sequence variations from dbSNP and Humsavar for SERPINB10 Gene

      SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
      rs502372 -- 63,932,308(-) agtta(A/T)cctag intron-variant
      rs585863 -- 63,916,579(-) TGTTG(C/G)TGTTG intron-variant
      rs620535 -- 63,920,055(-) AATTA(C/T)GTACA intron-variant
      rs620799 -- 63,927,994(-) TAGAC(A/G)GGTAA intron-variant
      rs682899 -- 63,929,906(-) TGGAC(A/C)AGTAC intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for SERPINB10 Gene

      Variant ID Type Subtype PubMed ID
      esv21739 CNV Gain 19812545
      nsv909693 CNV Gain 21882294
      nsv525889 CNV Loss 19592680
      dgv1034e1 CNV Complex 17122850
      nsv833673 CNV Gain 17160897
      essv7909 CNV CNV 17122850

      Relevant External Links for SERPINB10 Gene

      HapMap Linkage Disequilibrium report
      SERPINB10

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB10 Gene

      Disorders for SERPINB10 Gene

      (3) Novoseek inferred disease relationships for SERPINB10 Gene

      Disease -log(P) Hits PubMed IDs
      leukemia myelomonocytic chronic 75.4 2
      necrosis 9.06 3
      tumors 8.26 3

      Relevant External Links for SERPINB10

      Genetic Association Database (GAD)
      SERPINB10
      Human Genome Epidemiology (HuGE) Navigator
      SERPINB10
      genes like me logo Genes that share disorders with SERPINB10: view

      No data available for UniProtKB/Swiss-Prot for SERPINB10 Gene

      Publications for SERPINB10 Gene

      1. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. (PMID: 10871600) Schleef R.R. … Chuang T.L. (J. Biol. Chem. 2000) 2 3 4 23
      2. Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer. (PMID: 16172807) Shioji G. … Emi M. (J. Hum. Genet. 2005) 3 23 48
      3. Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment. (PMID: 20433722) Przygodzka P. … Wilczynska M. (BMC Cell Biol. 2010) 3 4 23
      4. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. (PMID: 7592909) Riewald M. … Schleef R.R. (J. Biol. Chem. 1995) 3 4 23
      5. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. (PMID: 10196205) Chuang T.L. … Schleef R.R. (J. Biol. Chem. 1999) 3 4 23

      Products for SERPINB10 Gene

      Sources for SERPINB10 Gene

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