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Aliases for SERPINB10 Gene

Aliases for SERPINB10 Gene

  • Serpin Family B Member 10 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 10 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 10 2 3
  • Peptidase Inhibitor 10 3 4
  • Bomapin 3 4
  • PI-10 3 4
  • PI10 3 4
  • Protease Inhibitor 10 (Ovalbumin Type, Bomapin) 3
  • Protease Inhibitor 10 (Ovalbumin Type 2
  • Bomapin) 2

External Ids for SERPINB10 Gene

Previous HGNC Symbols for SERPINB10 Gene

  • PI10

Previous GeneCards Identifiers for SERPINB10 Gene

  • GC18P061421
  • GC18P061556
  • GC18P061367
  • GC18P059731
  • GC18P059733
  • GC18P058283

Summaries for SERPINB10 Gene

Entrez Gene Summary for SERPINB10 Gene

  • This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]

GeneCards Summary for SERPINB10 Gene

SERPINB10 (Serpin Family B Member 10) is a Protein Coding gene. Among its related pathways are Amoebiasis and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB10 Gene

  • Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB10 Gene

Genomics for SERPINB10 Gene

Regulatory Elements for SERPINB10 Gene

Enhancers for SERPINB10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINB10 Gene

Chromosome:
18
Start:
63,897,174 bp from pter
End:
63,936,111 bp from pter
Size:
38,938 bases
Orientation:
Plus strand

Genomic View for SERPINB10 Gene

Genes around SERPINB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB10 Gene

Proteins for SERPINB10 Gene

  • Protein details for SERPINB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48595-SPB10_HUMAN
    Recommended name:
    Serpin B10
    Protein Accession:
    P48595
    Secondary Accessions:
    • Q4VAX4
    • Q4VAX7

    Protein attributes for SERPINB10 Gene

    Size:
    397 amino acids
    Molecular mass:
    45403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB10 Gene

Proteomics data for SERPINB10 Gene at MOPED

Post-translational modifications for SERPINB10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB10 Gene

No data available for DME Specific Peptides for SERPINB10 Gene

Domains & Families for SERPINB10 Gene

Gene Families for SERPINB10 Gene

Protein Domains for SERPINB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB10 Gene

Graphical View of Domain Structure for InterPro Entry

P48595

UniProtKB/Swiss-Prot:

SPB10_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB10: view

Function for SERPINB10 Gene

Molecular function for SERPINB10 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.
genes like me logo Genes that share phenotypes with SERPINB10: view

Animal Model Products

CRISPR Products

miRNA for SERPINB10 Gene

miRTarBase miRNAs that target SERPINB10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINB10 Gene

Localization for SERPINB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB10 Gene

Nucleus. Cytoplasm. Note=Mostly found in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB10 Gene COMPARTMENTS Subcellular localization image for SERPINB10 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SERPINB10 Gene

Pathways & Interactions for SERPINB10 Gene

genes like me logo Genes that share pathways with SERPINB10: view

Pathways by source for SERPINB10 Gene

1 BioSystems pathway for SERPINB10 Gene
1 KEGG pathway for SERPINB10 Gene

Interacting Proteins for SERPINB10 Gene

Gene Ontology (GO) - Biological Process for SERPINB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 7592909
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with SERPINB10: view

No data available for SIGNOR curated interactions for SERPINB10 Gene

Drugs & Compounds for SERPINB10 Gene

(1) Drugs for SERPINB10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SERPINB10: view

Transcripts for SERPINB10 Gene

mRNA/cDNA for SERPINB10 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINB10 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB10 Gene

No ASD Table

Relevant External Links for SERPINB10 Gene

GeneLoc Exon Structure for
SERPINB10
ECgene alternative splicing isoforms for
SERPINB10

Expression for SERPINB10 Gene

mRNA expression in normal human tissues for SERPINB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB10 Gene

This gene is overexpressed in Whole Blood (x21.6).

Protein differential expression in normal tissues from HIPED for SERPINB10 Gene

This gene is overexpressed in Monocytes (27.3), Peripheral blood mononuclear cells (19.9), and Neutrophil (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB10 Gene



SOURCE GeneReport for Unigene cluster for SERPINB10 Gene Hs.158339

mRNA Expression by UniProt/SwissProt for SERPINB10 Gene

P48595-SPB10_HUMAN
Tissue specificity: Expressed specifically in myeloid cells and the bone marrow.
genes like me logo Genes that share expression patterns with SERPINB10: view

Protein tissue co-expression partners for SERPINB10 Gene

Primer Products

In Situ Assay Products

Orthologs for SERPINB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINB10 35
  • 85.98 (n)
  • 80.1 (a)
SERPINB10 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB10 35
  • 84.89 (n)
  • 79.35 (a)
SERPINB10 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb10 35
  • 80.39 (n)
  • 74.79 (a)
Serpinb10 16
Serpinb10 36
  • 76 (a)
OneToMany
Serpinb10 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb10 35
  • 79.51 (n)
  • 72.29 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINB10 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINB10 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749622 35
  • 61.7 (n)
  • 51.77 (a)
-- 36
  • 49 (a)
OneToMany
SERPINB10 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SERPINB10 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii serpinb1l1 36
  • 49 (a)
ManyToMany
serpinb1l3 36
  • 42 (a)
ManyToMany
serpinb1l4 36
  • 44 (a)
ManyToMany
si:ch73-303g23.4 36
  • 42 (a)
ManyToMany
zgc:173729 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9455 37
  • 32 (a)
nec 37
  • 26 (a)
Spn2 37
  • 31 (a)
Spn3 37
  • 31 (a)
Spn4 37
  • 34 (a)
Spn43Aa 37
  • 29 (a)
Species with no ortholog for SERPINB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINB10 Gene

ENSEMBL:
Gene Tree for SERPINB10 (if available)
TreeFam:
Gene Tree for SERPINB10 (if available)

Paralogs for SERPINB10 Gene

genes like me logo Genes that share paralogs with SERPINB10: view

Variants for SERPINB10 Gene

Sequence variations from dbSNP and Humsavar for SERPINB10 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs963075 - 63,933,150(-) GTCAC(A/C/G)GCTTT reference, missense
rs8097425 - 63,915,633(+) ACCAT(A/G)GTGTA reference, missense
rs724558 - 63,918,026(+) AGAAA(C/T)CCTCA reference, missense, utr-variant-5-prime
rs9967382 - 63,919,833(+) CTCAG(C/T)CTGTT reference, missense
rs17072097 - 63,915,517(+) TGGAC(G/T)CTCTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINB10 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV Gain 19812545
nsv909693 CNV Gain 21882294
nsv525889 CNV Loss 19592680
dgv1034e1 CNV Complex 17122850
nsv833673 CNV Gain 17160897
essv7909 CNV CNV 17122850

Variation tolerance for SERPINB10 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.91; 99.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB10 Gene

HapMap Linkage Disequilibrium report
SERPINB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB10 Gene

Disorders for SERPINB10 Gene

Relevant External Links for SERPINB10

Genetic Association Database (GAD)
SERPINB10
Human Genome Epidemiology (HuGE) Navigator
SERPINB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB10

No disorders were found for SERPINB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINB10 Gene

Publications for SERPINB10 Gene

  1. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. (PMID: 10871600) Schleef R.R. … Chuang T.L. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment. (PMID: 20433722) Przygodzka P. … Wilczynska M. (BMC Cell Biol. 2010) 3 23
  4. Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer. (PMID: 16172807) Shioji G. … Emi M. (J. Hum. Genet. 2005) 3 23
  5. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. (PMID: 10196205) Chuang T.L. … Schleef R.R. (J. Biol. Chem. 1999) 3 23

Products for SERPINB10 Gene

Sources for SERPINB10 Gene

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