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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB10 Gene

protein-coding   GIFtS: 53
GCID: GC18P061556

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: PI10)
 Explore 4 diseases affiliated with
SERPINB10 via our new
 Human Malady Compendium 
Biological research products
for SERPINB10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 101 2     PI-102 3
PI101 2 3 5     Protease Inhibitor 10 (Ovalbumin Type, Bomapin)2
Bomapin3     Serpin B102
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 101 2     Bomapin3
Peptidase Inhibitor 102 3     

External Ids:    HGNC: 89421   Entrez Gene: 52732   Ensembl: ENSG000002425507   OMIM: 6020585   UniProtKB: P485953   

Export aliases for SERPINB10 gene to outside databases

Previous GC identifers: GC18P061421 GC18P061367 GC18P059731 GC18P059733 GC18P058283


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINB10:
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular
and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor
suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that
consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of
the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a
member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a
high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a
serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed
9268635)).(supplied by OMIM, Jan 2010)

UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and
apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB10 gene promoter:
         HNF-4alpha2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-4alpha1   AREB6   HFH-1   COMP1   IRF-7A   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

SERPINB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB10 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P061556:  view genomic region     (about GC identifiers)

Start:
61,564,408 bp from pter      End:
61,603,345 bp from pter
Size:
38,938 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595 (See protein sequence)
Recommended Name: Serpin B10  
Size: 397 amino acids; 45403 Da
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: Q4VAX4 Q4VAX7

Explore the universe of human proteins at neXtProt for SERPINB10: NX_P48595

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48595

  • SERPINB10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005015.1  
    ENSEMBL proteins: 
     ENSP00000381082   ENSP00000392381   ENSP00000238508  

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    Uscn Proteins for SERPINB10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    SERPINB10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SERPINB10 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P48595

    ProtoNet protein and cluster: P48595

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
    Function: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and
    apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0030414peptidase inhibitor activity ----


    SERPINB10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SERPINB10:
     Decreased POU5F1-GFP protein e 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway1.00
    Integrated Pancreatic Cancer Pathway0.99
    2Amoebiasis
    Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for SERPINB10 
        Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    1         Kegg Pathway  (Kegg details for SERPINB10):
        Amoebiasis


    SERPINB10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINB10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SERPINB10 (ENSP000002385084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSGENSP000002163364STRING: ENSP00000216336
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010466negative regulation of peptidase activity ----
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0045861negative regulation of proteolysis ----


    SERPINB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB10
    1 Novoseek chemical compound relationship for SERPINB10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 51.5 2 10871600 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB10 / SPB10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB10 gene: 
    NM_005024.1  

    Unigene Cluster for SERPINB10:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 10
    Hs.158339  [show with all ESTs]
    Unigene Representative Sequence: AK314936
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397996(uc002ljp.1) ENST00000418725(uc002ljq.1) ENST00000238508(uc010xev.2 uc010xew.2)


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    Additional cDNA sequence: 

    AK314936.1 BC096217.3 BC096218.3 BC096219.3 BC096220.3 U35459.1 

    1 DOTS entry:

    DT.92024982 

    2 AceView cDNA sequences:

    U35459 NM_005024 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACATATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SERPINB10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SERPINB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB10

    SOURCE GeneReport for Unigene cluster: Hs.158339

    UniProtKB/Swiss-Prot: SPB10_HUMAN, P48595
    Tissue specificity: Expressed specifically in the bone marrow

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB10 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SERPINB101 serpin peptidase inhibitor, clade B (ovalbumin), member more 60.32(n)
    49.49(a)
      395715  NM_204897.1  NP_990228.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINB106
    --
    58(a)
    1 ↔ 1
    GL343311.1(687839-699244)
    zebrafish
    (Danio rerio)
    Actinopterygii serpinb1l16
    si:ch73-303g23.46
    (see all 5)
    si:ch73-303g23.4
    (see all 5)
    48(a)
    43(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    16(54874440-54879870)
    16(54891752-54902149)


    ENSEMBL Gene Tree for SERPINB10 (if available)
    TreeFam Gene Tree for SERPINB10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB10 gene
    SERPINB72  SERPINB12  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/36 SIMAP similar genes for SERPINB10 using alignment to 4 protein entries:     SPB10_HUMAN (see all proteins) (see all similar genes):
    SERPINB2    PLANH2    DKFZp686O07189    SERPINB13    DKFZp686D06190    SERPINB1
    SERPINB11    SERPINB8    SERPINB9    SERPINB12    SERPINB4    AT3
    SERPINB3    SERPINB6    SCCA2    SERPINB7    SERPINA1    SERPINB5

    SERPINB10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/515 NCBI SNPs in SERPINB10 are shown (see all 515    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80860481,2
    C,F,A,--61580828(+) TTCTTG/AGCATT 1 -- us2k17Minor allele frequency- A:0.27WA NA CSA EA 366
    rs1918508561,2
    --61580831(+) TTGGCA/GTTGAT 1 -- us2k10--------
    rs1147092341,2
    F,--61580876(+) GTTGGT/CACAAT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1416037631,2
    C,--61580927(+) AGCAT-/GTAATC 1 -- us2k10--------
    rs1476454611,2
    --61580990(+) GATGGC/TTGGAG 1 -- us2k10--------
    rs65674051,2
    C,F,A,--61581171(+) GTGCTC/GCAATG 1 -- us2k16Minor allele frequency- G:0.30NA WA CSA EA 246
    rs711626891,2
    C,--61581200(+) AGTAT-/AGT   
      TAAGTC
    AGTTA
    1 -- us2k11Minor allele frequency- AGTTAAGTC:0.00NA 2
    rs123264171,2
    C,F,H,--61581241(+) TTTTGC/TCATTA 1 -- us2k19Minor allele frequency- T:0.03NS EA NA WA 890
    rs1179111201,2
    F,--61581325(+) CACTGC/TTCTAT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs748971251,2
    C,F,--61581354(+) GATAGC/TCCTTC 1 -- us2k18Minor allele frequency- T:0.27WA NA CSA EA 367

    HapMap Linkage Disequilibrium report for SERPINB10 (61564408 - 61603345 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SERPINB10
         3 CNVs: 88880 3172 67377

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB10
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SERPINB10 for disorders           About GeneDecksing

    OMIM gene information: 602058    OMIM disorders: --

    4 diseases for SERPINB10:    About MalaCards
    edwards syndrome    hematopoiesis    prostate cancer    prostatitis

    3 Novoseek disease relationships for SERPINB10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia myelomonocytic chronic 75.4 3 9454755 (1), 10871600 (1)
    necrosis 9.06 3 10871600 (2), 9454755 (1)
    tumors 8.26 3 10871600 (2), 9454755 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB10 (1 document)

    Export disorders for SERPINB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB10 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SERPINB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. (PubMed id 10871600)1, 2, 3, 9 Schleef R.R. and Chuang T.L. (2000)
    2. Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10. (PubMed id 10196205)1, 2, 9 Chuang T.L. and Schleef R.R. (1999)
    3. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. (PubMed id 7592909)1, 2, 9 Riewald M. and Schleef R.R. (1995)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. (PubMed id 9268635)1, 3 Bartuski A.J....Silverman G.A. (1997)
    6. Bomapin is a redox-sensitive nuclear serpin that affe cts responsiveness of myeloid progenitor cells to growth environment. (PubMed id 20433722)1, 9 Przygodzka P....Wilczynska M. (2010)
    7. Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer. (PubMed id 16172807)1, 9 Shioji G....Emi M. (2005)
    8. Novel pancreatic beta cell-specific proteins: antibody -based proteomics for identification of new biomarker candidates. (PubMed id 22465717)1 Lindskog C....Danielsson A. (2012)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Implications of the three-dimensional structure of al pha 1-antitrypsin for structure and function of serpins. (PubMed id 2690952)1 Huber R. and Carrell R.W. (1989)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5273 HGNC: 8942 AceView: SERPINB10 Ensembl:ENSG00000242550 euGenes: HUgn5273
    ECgene: SERPINB10 Kegg: 5273 H-InvDB: SERPINB10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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