Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB1 Gene

protein-coding   GIFtS: 60
GCID: GC06M002833

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: ELANH2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2     MNEI2 3
ELANH21 2 3 5     PI-22 3
EI2 3 5     PI22 3
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2     Leukocyte Elastase Inhibitor2
Peptidase Inhibitor 22 3     Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived2
LEI2 3     Monocyte/Neutrophil Elastase Inhibitor3
M/NEI2 3     Serpin B13

External Ids:    HGNC: 33111   Entrez Gene: 19922   Ensembl: ENSG000000213557   OMIM: 1301355   UniProtKB: P307403   

Export aliases for SERPINB1 gene to outside databases

Previous GC identifers: GC06M002817 GC06M002778 GC06M002707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINB1 Gene:
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family
maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide
substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and
proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for SERPINB1 Gene: 
SERPINB1 (serpin peptidase inhibitor, clade B (ovalbumin), member 1) is a protein-coding gene. Diseases associated with SERPINB1 include thromboangiitis obliterans, and bronchitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE2.

UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H

Gene Wiki entry for SERPINB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB1 gene promoter:
         TBP   NF-AT4   POU2F1   POU2F1a   STAT3   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SERPINB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002833:  view genomic region     (about GC identifiers)

Start:
2,832,566 bp from pter      End:
2,842,240 bp from pter
Size:
9,675 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740 (See protein sequence)
Recommended Name: Leukocyte elastase inhibitor  
Size: 379 amino acids; 42742 Da
Subunit: Monomer
Subcellular location: Cytoplasm (By similarity). Cytoplasmic granule
Sequence caution: Sequence=BAD97090.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SERPINB1:
4GA7 (3D)    
Secondary accessions: A8K5L2 Q53FB9 Q5W0E1 Q9UDF8

Explore the universe of human proteins at neXtProt for SERPINB1: NX_P30740

Explore proteomics data for SERPINB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30740

  • SERPINB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINB1 Protein Expression
    REFSEQ proteins: NP_109591.1  
    ENSEMBL proteins: 
     ENSP00000370115   ENSP00000444543  

    Human Recombinant Protein Products for SERPINB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERPINB1
    OriGene Protein Over-expression Lysate for SERPINB1
    OriGene MassSpec for SERPINB1 
    OriGene Custom Protein Services for SERPINB1
    GenScript Custom Purified and Recombinant Proteins Services for SERPINB1
    Novus Biologicals SERPINB1 Proteins
    Novus Biologicals SERPINB1 Lysates
    Sino Biological Recombinant Protein for SERPINB1
    Sino Biological Cell Lysate for SERPINB1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm NAS--

    SERPINB1 for ontologies           About GeneDecksing



    SERPINB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SERPINB1
    OriGene Custom Antibody Services for SERPINB1
    GenScript Custom Superior Antibodies Services for SERPINB1
    Novus Biologicals SERPINB1 Antibodies
    Abcam antibodies for SERPINB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SERPINB1
    LSBio Antibodies in human, mouse, rat for SERPINB1 

    Assay Products for SERPINB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERPINB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERPINB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    4 InterPro protein domains:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR015557 Protease_inhib_serpin_B1
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P30740

    ProtoNet protein and cluster: P30740

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
    Domain: Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G,
    chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease
    such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILEU_HUMAN, P30740
    Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
    chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS1376927
         
    SERPINB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB1:
     Decreased melanin production  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpinb1a):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    SERPINB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpinb1atm1.1Cben for SERPINB1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERPINB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERPINB1
    Sirion Biotech Customized adenovirus for overexpression of SERPINB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SERPINB1 (see all 7)
    OriGene ORF clones in mouse, rat for SERPINB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERPINB1 (NM_030666)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1
    Sirion Biotech Customized lentivirus for stable overexpression of SERPINB1 
                         Customized lentivirus expression plasmids for stable overexpression of SERPINB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERPINB1
    Search LifeMap BioReagents cell lines for SERPINB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for SERPINB1):
        Amoebiasis


    SERPINB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SERPINB1 (P307403 ENSP000003701154) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTN3P241583, ENSP000002343474I2D: score=3 STRING: ENSP00000234347
    CTSGP083113, ENSP000002163364I2D: score=1 STRING: ENSP00000216336
    ELANEP082463, ENSP000002636214I2D: score=4 STRING: ENSP00000263621
    RPS21P632203I2D: score=2 
    AICDAQ9GZX73I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    SERPINB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB1 (ILEU)

    7 Novoseek inferred chemical compound relationships for SERPINB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 40.5 4 19213596 (2), 18761000 (1)
    hydralazine 30 1 2168822 (1)
    superoxide 16.5 1 16595910 (1)
    heparin 10.5 4 7768918 (2), 12702549 (1), 7873546 (1)
    acetone 5.14 1 9257786 (1)
    h2o2 2.35 1 1334093 (1)
    calcium 0 4 9514602 (1), 12766385 (1), 8870026 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB1 / ILEU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINB1 gene: 
    NM_030666.3  

    Unigene Cluster for SERPINB1:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 1
    Hs.381167  [show with all ESTs]
    Unigene Representative Sequence: NR_073111
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380739(uc003mub.3) ENST00000468511 ENST00000490094 ENST00000476896
    ENST00000460260 ENST00000537185(uc021ykq.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERPINB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1
    Clone
    Products:
         
    OriGene clones in human, mouse for SERPINB1 (see all 7)
    OriGene ORF clones in mouse, rat for SERPINB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERPINB1 (NM_030666)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1
    Sirion Biotech Customized lentivirus for stable overexpression of SERPINB1 
                         Customized lentivirus expression plasmids for stable overexpression of SERPINB1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERPINB1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1

    Additional mRNA sequence: 

    AK223370.1 AK291327.1 AK298044.1 AK304641.1 AK309765.1 AK312973.1 BC009015.1 BT006928.1 
    M93056.1 NR_073111.1 NR_073112.1 

    15 DOTS entries:

    DT.215900  DT.97822870  DT.95364007  DT.100882285  DT.91639094  DT.100882257  DT.100882277  DT.100882282 
    DT.105586  DT.121406605  DT.75183304  DT.95364006  DT.95364008  DT.95364021  DT.121406595 

    24/374 AceView cDNA sequences (see all 374):

    AW377621 AI433145 BM831182 CR626605 AU141498 CR610002 BU623768 BM353632 
    BM785872 AL597159 CA312485 BM834115 BM826883 BM021169 BM818915 BQ420430 
    AU076563 BM830765 BU164576 BX110373 NM_030666 BM790759 BM919832 BM831353 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ·
    SP1:                                      -     -     -                             -     -     -                                                               
    SP2:                                      -     -     -                             -     -                                                                     
    SP3:                                      -     -     -                       -     -     -     -                                                               
    SP4:                                      -     -     -                             -     -     -                       -                                       
    SP5:                                      -           -                             -     -     -                                                               

    ExUns: 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SERPINB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB1 expression in normal human tissues (normalized intensities)      SERPINB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGATGCCCG
    SERPINB1 Expression
    About this image


    SERPINB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             bone marrow   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             bone marrow   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   
     
     Pancreas (Endocrine System)
             pancreas ; exocrine glandular cells   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   

    See SERPINB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB1

    SOURCE GeneReport for Unigene cluster: Hs.381167
        SABiosciences Custom PCR Arrays for SERPINB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SERPINB1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINB1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb1a1 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 81.44(n)1
    80.47(a)1
      13 (13.75 cM)5
    662221  NM_025429.21  NP_079705.21 
     328420925 
    chicken
    (Gallus gallus)
    Aves SERPINB16
    Uncharacterized protein
    69(a)
    1 ↔ 1
    2(67710614-67719508)
    lizard
    (Anolis carolinensis)
    Reptilia --
    SERPINB16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    64(a)
    60(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343311.1(763485-775454)
    GL343311.1(720723-751483)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257522 Xenopus laevis transcribed sequence with weak similarity more 74.87(n)    BJ628196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398415.12   -- 74.87(n)    AY398415.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G477101 serpin-ZX 44.35(n)
    31.69(a)
      841182  NM_103664.3  NP_175202.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06106501 hypothetical protein 50.56(n)
    46.22(a)
      9270857  NM_001186604.1  NP_001173533.1 


    ENSEMBL Gene Tree for SERPINB1 (if available)
    TreeFam Gene Tree for SERPINB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB1 gene
    SERPINE22  SERPINB72  SERPINI12  SERPINB52  SERPINB122  SERPINB62  SERPINI22  SERPINB22  
    SERPINC12  SERPINB102  SERPINB92  SERPINB32  SERPINE12  SERPINB112  SERPINE32  SERPINB42  
    SERPINB82  SERPINB132  
    18/36 SIMAP similar genes for SERPINB1 using alignment to 2 protein entries:     ILEU_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O07189    SERPINB6    SERPINB9    SERPINB8    SERPINB5    SERPINB10
    SERPINB3    SERPINB13    AT3    DKFZp686D06190    SERPINB11    SERPINB12
    SERPINB2    SERPINB4    SCCA2    SERPINB7    SERPINI2    SERPINA3

    SERPINB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/359 SNPs in SERPINB1 are shown (see all 359)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3163631,2
    C,F,O,A,H--2832078(-) AGTCAA/GTTAAA 3 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 2715
    rs1834832811,2
    --2832091(+) AGAGGC/TCTGAG 3 -- ds50010--------
    rs1884178831,2
    C--2832094(+) GGCCTG/TAGGTA 3 -- ds50010--------
    rs1921539871,2
    --2832109(+) TTTCAC/TCATTA 3 -- ds50010--------
    rs121988091,2
    C,F,H--2832137(+) CCACAT/CAAAAT 3 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs598680911,2
    C--2832146(+) ATACGC/AATTGG 3 -- ds50014Minor allele frequency- A:0.16CSA WA EA 241
    rs1839698251,2
    --2832208(+) ACTTAC/TAGTCT 3 -- ds50010--------
    rs3163621,2
    C,F,A,H--2832331(-) CTCTTT/CTGGTT 3 -- ds500122Minor allele frequency- C:0.27NS EA NA CSA WA 2762
    rs1410583981,2
    C--2832349(+) CAGAA-/GGGCAG 3 -- ds50010--------
    rs3163611,2
    C,F,H--2832411(-) TTTTCC/TCCCGC 3 -- ds500115Minor allele frequency- T:0.02NS EA NA WA CSA 794

    HapMap Linkage Disequilibrium report for SERPINB1 (2832566 - 2842240 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SERPINB1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 130135    OMIM disorders: --

    20/44 diseases for SERPINB1 (see all 44):    About MalaCards
    thromboangiitis obliterans    bronchitis    alpha 1-antitrypsin deficiency    pulmonary emphysema
    wegener's granulomatosis    pneumothorax    cowpox    vasculitis
    hemolytic-uremic syndrome    interstitial lung disease    bronchiectasis    bronchopulmonary dysplasia
    angioedema    idiopathic pulmonary fibrosis    urticaria    autoimmune thyroiditis
    pulmonary fibrosis    pneumonia    hernia    vaccinia

    4 diseases from the University of Copenhagen DISEASES database for SERPINB1:
    Alpha 1-antitrypsin deficiency     Cowpox     Urticaria     Carcinoma

    SERPINB1 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for SERPINB1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pulmonary emphysema 72.8 4 2368980 (2), 8315277 (1), 10497394 (1)
    bronchoalveolar lavage fluid 59.1 6 7720229 (2), 9872847 (1), 7616758 (1), 12600833 (1)
    wegeners granulomatosis 50 1 1851056 (1)
    vasculitis 46 2 1655318 (1), 1851056 (1)
    psoriasis 36.8 2 1929539 (1), 2001428 (1)
    inflammation 36 6 1374264 (1), 1336720 (1), 12689923 (1), 1652455 (1) (see all 6)
    lung diseases 32 1 12162104 (1)
    pulmonary disease chronic obstructive 31.2 2 11889128 (1), 16596021 (1)
    bronchitis chronic 30 1 2368980 (1)
    pneumonia 18.3 7 12600833 (4), 18840548 (2), 2178530 (1)

    Genetic Association Database (GAD): SERPINB1
    Human Genome Epidemiology (HuGE) Navigator: SERPINB1 (2 documents)

    Export disorders for SERPINB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB1 gene, integrated from 9 sources (see all 156):
    (articles sorted by number of sources associating them with SERPINB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. (PubMed id 1376927)1, 2, 3 Remold-O'Donnell E.... Alberts M. (1992)
    2. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. (PubMed id 23269243)1, 2 Wang L.... Fan Z. (2013)
    3. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    4. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. (PubMed id 11747453)1, 2 Cooley J....Remold-O'Donnell E. (2001)
    9. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. (PubMed id 9630619)1, 2 Zeng W.... Remold-O'Donnell E. (1998)
    10. A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes. (PubMed id 7578269)1, 2 Packard B.Z.... Komoriya A. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1992 HGNC: 3311 AceView: SERPINB1 Ensembl:ENSG00000021355 euGenes: HUgn1992
    ECgene: SERPINB1 Kegg: 1992 H-InvDB: SERPINB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINB1 gene:
    Search GeneIP for patents involving SERPINB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SERPINB1   OriGene RNAi products in human, mouse, rat for SERPINB1  
     OriGene qPCR primer pairs and template standards for SERPINB1   OriGene Protein Over-expression Lysate for SERPINB1  
     OriGene MassSpec something-or-other for SERPINB1   OriGene clones in human, mouse for SERPINB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SERPINB1   OriGene Purified Protein for SERPINB1  
     OriGene ORF clones in mouse, rat for SERPINB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERPINB1   OriGene Custom Protein Services for SERPINB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB1
     QIAGEN SeqTarget long-range PCR primers for resequencing SERPINB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
     GenScript Custom Purified and Recombinant Proteins Services for SERPINB1 GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB1
     GenScript Custom Assay Services for SERPINB1 GenScript Custom Superior Antibodies Services for SERPINB1
     GenScript Custom overexpressing Cell Line Services for SERPINB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERPINB1 promoter
     Search Chromatin IP Primers for SERPINB1
     RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
     GNC Network for SERPINB1
     SABiosciences Custom PCR Arrays for SERPINB1
     Search Tocris compounds for SERPINB1 (ILEU)
     Proteins and Antibodies for SERPINB1
     Cell Lysates for SERPINB1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERPINB1 antibodies
     SERPINB1 proteins
     SERPINB1 lysates
     Antibodies for SERPINB1
     See all of Abcam's Antibodies, Kits and Proteins for SERPINB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SERPINB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SERPINB1
     SwitchGear Promoter luciferase reporter plasmids for SERPINB1
     ThermoFisher Antibodies for SERPINB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINB1
    Customized:
     lentivirus for stable overexpression of SERPINB1
     lentivirus expression plasmids for stable overexpression of SERPINB1
     adenovirus for overexpression of SERPINB1
     LSBio Antibodies in human, mouse, rat for SERPINB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SERPINB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4