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Aliases for SERPINB1 Gene

Aliases for SERPINB1 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1 2 3
  • ELANH2 3 4 6
  • EI 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 1 2 3
  • Peptidase Inhibitor 2 3 4
  • M/NEI 3 4
  • MNEI 3 4
  • PI-2 3 4
  • LEI 3 4
  • PI2 3 4
  • Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived 3
  • Monocyte/Neutrophil Elastase Inhibitor 4
  • Epididymis Luminal Protein 57 3
  • Leukocyte Elastase Inhibitor 3
  • Serpin B1 4
  • HEL57 3

External Ids for SERPINB1 Gene

Previous HGNC Symbols for SERPINB1 Gene

  • ELANH2

Previous GeneCards Identifiers for SERPINB1 Gene

  • GC06M002817
  • GC06M002778
  • GC06M002707

Summaries for SERPINB1 Gene

Entrez Gene Summary for SERPINB1 Gene

  • The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for SERPINB1 Gene

SERPINB1 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1) is a Protein Coding gene. Diseases associated with SERPINB1 include thromboangiitis obliterans and pulmonary disease, chronic obstructive. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB1 Gene

  • Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.

Gene Wiki entry for SERPINB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB1 Gene

Genomics for SERPINB1 Gene

Regulatory Elements for SERPINB1 Gene

Genomic Location for SERPINB1 Gene

Start:
2,832,332 bp from pter
End:
2,842,049 bp from pter
Size:
9,718 bases
Orientation:
Minus strand

Genomic View for SERPINB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB1 Gene

Proteins for SERPINB1 Gene

  • Protein details for SERPINB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30740-ILEU_HUMAN
    Recommended name:
    Leukocyte elastase inhibitor
    Protein Accession:
    P30740
    Secondary Accessions:
    • A8K5L2
    • B4DNT0
    • Q53FB9
    • Q5W0E1
    • Q9UDF8

    Protein attributes for SERPINB1 Gene

    Size:
    379 amino acids
    Molecular mass:
    42742 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAD97090.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINB1 Gene

    Alternative splice isoforms for SERPINB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINB1 Gene

Proteomics data for SERPINB1 Gene at MOPED

Post-translational modifications for SERPINB1 Gene

  • Ubiquitination at Lys177 and Lys196
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINB1 Gene

Domains for SERPINB1 Gene

Gene Families for SERPINB1 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P30740

UniProtKB/Swiss-Prot:

ILEU_HUMAN :
  • P30740
Domain:
  • Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB1: view

Function for SERPINB1 Gene

Molecular function for SERPINB1 Gene

UniProtKB/Swiss-Prot Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.

Gene Ontology (GO) - Molecular Function for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity NAS 1376927
genes like me logo Genes that share ontologies with SERPINB1: view
genes like me logo Genes that share phenotypes with SERPINB1: view

Animal Models for SERPINB1 Gene

MGI Knock Outs for SERPINB1:

miRNA for SERPINB1 Gene

miRTarBase miRNAs that target SERPINB1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINB1 Gene

Localization for SERPINB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB1 Gene

Cytoplasm. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB1 Gene COMPARTMENTS Subcellular localization image for SERPINB1 gene
Compartment Confidence
extracellular 4
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SERPINB1: view

Pathways for SERPINB1 Gene

SuperPathways for SERPINB1 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB1: view

Pathways by source for SERPINB1 Gene

1 KEGG pathway for SERPINB1 Gene

Gene Ontology (GO) - Biological Process for SERPINB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINB1: view

Compounds for SERPINB1 Gene

(7) Novoseek inferred chemical compound relationships for SERPINB1 Gene

Compound -log(P) Hits PubMed IDs
serine 40.5 3
hydralazine 30 1
superoxide 16.5 1
heparin 10.5 4
acetone 5.14 1
genes like me logo Genes that share compounds with SERPINB1: view

Transcripts for SERPINB1 Gene

Unigene Clusters for SERPINB1 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7:
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - -
SP11:
SP12:
SP13: -
SP14: - - -

ExUns: 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for SERPINB1 Gene

GeneLoc Exon Structure for
SERPINB1
ECgene alternative splicing isoforms for
SERPINB1

Expression for SERPINB1 Gene

mRNA expression in normal human tissues for SERPINB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB1 Gene

This gene is overexpressed in Whole Blood (14.2), Esophagus - Mucosa (8.3), and Pancreas (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINB1 Gene

SOURCE GeneReport for Unigene cluster for SERPINB1 Gene Hs.381167

genes like me logo Genes that share expressions with SERPINB1: view

No data available for mRNA Expression by UniProt/SwissProt for SERPINB1 Gene

Orthologs for SERPINB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB1 35
  • 99.12 (n)
  • 98.68 (a)
SERPINB1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB1 35
  • 78.43 (n)
  • 78.51 (a)
SERPINB1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINB1 35
  • 82.88 (n)
  • 81.46 (a)
SERPINB1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb1a 35
  • 81.44 (n)
  • 80.47 (a)
Serpinb1a 16
Serpinb1a 36
  • 80 (a)
OneToMany
Serpinb1b 36
  • 76 (a)
OneToMany
Serpinb1c 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SERPINB1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb1a 35
  • 82.23 (n)
  • 81.79 (a)
chicken
(Gallus gallus)
Aves SERPINB1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25752 35
tropical clawed frog
(Silurana tropicalis)
Amphibia serpinb1 35
  • 65.25 (n)
  • 62.77 (a)
zebrafish
(Danio rerio)
Actinopterygii serpinb1 35
  • 60.05 (n)
  • 56.88 (a)
serpinb1 36
  • 56 (a)
OneToMany
serpinb1l2 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Spn43Ab 37
  • 29 (a)
Spn5 37
  • 30 (a)
Spn3 37
  • 33 (a)
Spn2 37
  • 33 (a)
Spn43Aa 37
  • 33 (a)
CG9455 37
  • 34 (a)
CG9460 37
  • 33 (a)
CG6687 37
  • 27 (a)
Spn1 37
  • 35 (a)
nec 37
  • 30 (a)
CG6717 37
  • 33 (a)
Spn6 37
  • 35 (a)
CG7722 37
  • 28 (a)
Spn4 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-7 37
  • 29 (a)
srp-1 37
  • 28 (a)
srp-6 37
  • 29 (a)
Species with no ortholog for SERPINB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERPINB1 Gene

ENSEMBL:
Gene Tree for SERPINB1 (if available)
TreeFam:
Gene Tree for SERPINB1 (if available)

Paralogs for SERPINB1 Gene

genes like me logo Genes that share paralogs with SERPINB1: view

Variants for SERPINB1 Gene

Sequence variations from dbSNP and Humsavar for SERPINB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15286 -- 2,833,505(-) ACTGT(C/T)CAGAA utr-variant-3-prime, nc-transcript-variant
rs316337 -- 2,837,378(-) TCTCT(C/T)GAACA intron-variant
rs316338 -- 2,837,612(-) AACTT(C/T)TAAAG intron-variant
rs316339 -- 2,837,812(+) CAGGT(A/G)GGGAA intron-variant
rs316340 -- 2,837,868(-) CTGGG(C/T)AGAAT intron-variant

Relevant External Links for SERPINB1 Gene

HapMap Linkage Disequilibrium report
SERPINB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SERPINB1 Gene

Disorders for SERPINB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SERPINB1 Gene including...

Search for SERPINB1 Gene in MalaCards »

(4) University of Copenhagen DISEASES for SERPINB1 Gene

(15) Novoseek inferred disease relationships for SERPINB1 Gene

Disease -log(P) Hits PubMed IDs
pulmonary emphysema 72.8 4
bronchoalveolar lavage fluid 59.1 5
wegeners granulomatosis 50 1
vasculitis 46 2
psoriasis 36.8 2

Relevant External Links for SERPINB1

Genetic Association Database (GAD)
SERPINB1
Human Genome Epidemiology (HuGE) Navigator
SERPINB1
genes like me logo Genes that share disorders with SERPINB1: view

No data available for UniProtKB/Swiss-Prot for SERPINB1 Gene

Publications for SERPINB1 Gene

  1. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. (PMID: 1376927) Remold-O'Donnell E. … Alberts M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  2. A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes. (PMID: 7578269) Packard B.Z. … Komoriya A. (Biochim. Biophys. Acta 1995) 3 4
  3. Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. (PMID: 19213596) Tseng M.Y. … Chen J.Y. (Oral Oncol. 2009) 3 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for SERPINB1 Gene

Sources for SERPINB1 Gene

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