Aliases for SERPINB1 Gene
External Ids for SERPINB1 Gene
Previous HGNC Symbols for SERPINB1 Gene
Previous GeneCards Identifiers for SERPINB1 Gene
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINB1 Gene
SERPINB1 (Serpin Family B Member 1) is a Protein Coding gene. Diseases associated with SERPINB1 include Pulmonary Emphysema and Holoprosencephaly 11. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB8.
UniProtKB/Swiss-Prot for SERPINB1 Gene
Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.