Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINB1 Gene

protein-coding   GIFtS: 56
GCID: GC06M002833

serpin peptidase inhibitor, clade B (ovalbumin), member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: ELANH2)
 Explore 42 diseases affiliated with
SERPINB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINB1    

Aliases
for SERPINB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2     MNEI2 3
EI1 2 3 5     PI-22 3
ELANH21 2 3 5     Anti-Elastase1
PI21 2 3     Leukocyte Elastase Inhibitor2
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2     Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived2
Peptidase Inhibitor 22 3     Monocyte/Neutrophil Elastase Inhibitor3
LEI2 3     Serpin B13
M/NEI2 3     

External Ids:    HGNC: 33111   Entrez Gene: 19922   Ensembl: ENSG000000213557   OMIM: 1301355   UniProtKB: P307403   

Export aliases for SERPINB1 gene to outside databases

Previous GC identifers: GC06M002817 GC06M002778 GC06M002707


Summaries
for SERPINB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SERPINB1:
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family
maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates.
This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus
protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
chymotrypsin, and kallikrein-3

Gene Wiki entry for SERPINB1


Genomic Views
for SERPINB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINB1 gene promoter:
         TBP   NF-AT4   POU2F1   POU2F1a   STAT3   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SERPINB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002833:  view genomic region     (about GC identifiers)

Start:
 2,832,566 bp from pter      End:
 2,842,240 bp from pter
Size:
 9,675 bases      Orientation:
 minus strand

Proteins
for SERPINB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740 (See protein sequence)
Recommended Name: Leukocyte elastase inhibitor  
Size: 379 amino acids; 42742 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAD97090.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SERPINB1:
4GA7 (3D)    
Secondary accessions: A8K5L2 Q53FB9 Q5W0E1 Q9UDF8

Explore the universe of human proteins at neXtProt for SERPINB1: NX_P30740

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30740

    • SERPINB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_109591.1  
    ENSEMBL proteins: 
     ENSP00000370115   ENSP00000444543  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SERPINB1
    OriGene Protein Over-expression Lysate: SERPINB1
    OriGene Custom Protein Services for SERPINB1 
    GenScript Custom Purified and Recombinant Proteins Services for SERPINB1
    Novus Biologicals SERPINB1 Proteins
    Novus Biologicals SERPINB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINB1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm NAS--


    SERPINB1 for ontologies           About GeneDecksing



    SERPINB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 6): SERPINB1
    OriGene Custom Antibody Services for SERPINB1 
    GenScript Custom Superior Antibodies Services for SERPINB1
    Novus Biologicals SERPINB1 Antibodies
    Abcam antibodies for SERPINB1 
    Uscn Antibodies for SERPINB1
    Search ThermoFisher Antibodies for SERPINB1

    Assay Products for SERPINB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERPINB1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERPINB1

    Protein Domains /
    Families
    for SERPINB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINB1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR015557 Protease_inhib_serpin_B1
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P30740

    ProtoNet protein and cluster: P30740

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
    Domain: Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or
    chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase,
    proteinase-3, pancreatic elastase or PSA
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    Function
    for SERPINB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
    Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
    chymotrypsin, and kallikrein-3

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SERPINB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB1 (see all 7)
    OriGene shRNA RFP: SERPINB1
    OriGene siRNA: SERPINB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SERPINB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB1 (NM_030666)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SERPINB1
    Search LifeMap BioReagents cell lines for SERPINB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS1376927


    SERPINB1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SERPINB1:
     Decreased melanin production  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Serpinb1atm1.1Cben for SERPINB1
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpinb1a):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    SERPINB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SERPINB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SERPINB1):
        Amoebiasis


    SERPINB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINB1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SERPINB1 (P307403 ENSP000003701154) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTN3P241583, ENSP000002343474I2D: score=3 STRING: ENSP00000234347
    CTSGP083113, ENSP000002163364I2D: score=1 STRING: ENSP00000216336
    ELANEP082463, ENSP000002636214I2D: score=4 STRING: ENSP00000263621
    RPS21P632203I2D: score=2 
    AICDAQ9GZX73I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--


    SERPINB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINB1
    7 Novoseek chemical compound relationships for SERPINB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 40.5 4 19213596 (2), 18761000 (1)
    hydralazine 30 1 2168822 (1)
    superoxide 16.5 1 16595910 (1)
    heparin 10.5 4 7768918 (2), 12702549 (1), 7873546 (1)
    acetone 5.14 1 9257786 (1)
    h2o2 2.35 1 1334093 (1)
    calcium 0 4 9514602 (1), 12766385 (1), 8870026 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINB1 / ILEU 

    Transcripts
    for SERPINB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINB1 gene: 
    NM_030666.3  

    Unigene Cluster for SERPINB1:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 1
    Hs.381167  [show with all ESTs]
    Unigene Representative Sequence: NR_073111
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380739(uc003mub.3) ENST00000468511 ENST00000490094 ENST00000476896
    ENST00000460260 ENST00000537185(uc021ykq.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SERPINB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERPINB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB1 (see all 7)
    OriGene shRNA RFP: SERPINB1
    OriGene siRNA: SERPINB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SERPINB1 (NM_030666)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1

    Additional cDNA sequence: 

    AK223370.1 AK291327.1 AK298044.1 AK304641.1 AK309765.1 AK312973.1 BC009015.1 BT006928.1 
    M93056.1 NR_073111.1 NR_073112.1 

    15 DOTS entries:

    DT.215900  DT.97822870  DT.95364007  DT.100882285  DT.91639094  DT.100882257  DT.100882277  DT.100882282 
    DT.105586  DT.121406605  DT.75183304  DT.95364006  DT.95364008  DT.95364021  DT.121406595 

    24/374 AceView cDNA sequences (see all 374):

    AU076563 BQ954796 BM773487 BM822295 BQ220429 BM818915 BI818426 BM826883 
    CR600548 BI768241 BM837376 CA312485 AA830260 BT006928 BQ720931 BX110373 
    BU623768 BM834115 BM021169 BQ232802 BM821949 CB145708 AU141498 BP350184 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ·
    SP1:                                      -     -     -                             -     -     -                                                               
    SP2:                                      -     -     -                             -     -                                                                     
    SP3:                                      -     -     -                       -     -     -     -                                                               
    SP4:                                      -     -     -                             -     -     -                       -                                       
    SP5:                                      -           -                             -     -     -                                                               

    ExUns: 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SERPINB1

    Expression
    for SERPINB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGATGCCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SERPINB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    KidneyS-shaped BodyKidney
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See SERPINB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINB1

    SOURCE GeneReport for Unigene cluster: Hs.381167
        SABiosciences Custom PCR Arrays for SERPINB1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1

    Orthologs
    for SERPINB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINB1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves E1BTH0_CHICK6
    		 Uncharacterized protein
    		 67(a)
    		 1 ↔ 1
    		 2(68846225-68853297)
    lizard
    (Anolis carolinensis)    		 Reptilia SERPINB16
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343311.1(739322-749599)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.257522 Xenopus laevis transcribed sequence with weak similarity more 74.87(n)    BJ628196.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AY398415.12   -- 74.87(n)    AY398415.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G477101 serpin-ZX 44.35(n)
    31.69(a)    		   841182  NM_103664.3  NP_175202.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g06106501 hypothetical protein 50.56(n)
    46.22(a)    		   9270857  NM_001186604.1  NP_001173533.1 


    ENSEMBL Gene Tree for SERPINB1 (if available)
    TreeFam Gene Tree for SERPINB1 (if available) 

    Paralogs
    for SERPINB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINB1 gene
    SERPINB72  SERPINI12  SERPINB52  SERPINB122  SERPINI22  SERPINB22  SERPINB102  SERPINB32  
    SERPINB42  SERPINE22  SERPINB62  SERPINC12  SERPINB92  SERPINE12  SERPINE32  SERPINB132  
    SERPINB82  
    18/36 SIMAP similar genes for SERPINB1 using alignment to 2 protein entries:     ILEU_HUMAN (see all proteins) (see all similar genes):
    SERPINB6    DKFZp686O07189    SERPINB9    SERPINB8    SERPINB5    SERPINB10
    SERPINB3    SERPINB13    AT3    DKFZp686D06190    SERPINB11    SERPINB12
    SERPINB2    SERPINB4    SCCA2    SERPINB7    SERPINI2    SERPINA3

    SERPINB1 for paralogs           About GeneDecksing



    Genomic Variants
    for SERPINB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 NCBI SNPs in SERPINB1 are shown (see all 300)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs3163631,2
    		C,F,O,A,H,--2832078(-) AGTCAA/GTTAAA 3 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 2715
    rs1834832811,2
    		--2832091(+) AGAGGC/TCTGAG 3 -- ds50010--------
    rs1884178831,2
    		--2832094(+) GGCCTG/TAGGTA 3 -- ds50010--------
    rs1921539871,2
    		--2832109(+) TTTCAC/TCATTA 3 -- ds50010--------
    rs121988091,2
    		H,--2832137(+) CCACAT/CAAAAT 3 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs598680911,2
    		C,--2832146(+) ATACGC/AATTGG 3 -- ds50014Minor allele frequency- A:0.16CSA WA EA 241
    rs1839698251,2
    		--2832208(+) ACTTAC/TAGTCT 3 -- ds50010--------
    rs3163621,2
    		C,F,A,H,--2832331(-) CTCTTT/CTGGTT 3 -- ds500122Minor allele frequency- C:0.27NS EA NA CSA WA 2762
    rs1410583981,2
    		C,--2832349(+) CAGAA-/GGGCAG 3 -- ds50010--------
    rs3163611,2
    		C,F,H,--2832411(-) TTTTCC/TCCCGC 3 -- ds500115Minor allele frequency- T:0.02NS EA NA WA CSA 794

    HapMap Linkage Disequilibrium report for SERPINB1 (2832566 - 2842240 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SERPINB1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB1

    Disorders / Diseases
    for SERPINB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINB1 for disorders           About GeneDecksing

    OMIM gene information: 130135    OMIM disorders: --

    20/42 diseases for SERPINB1 (see all 42):    About MalaCards
    alpha 1-antitrypsin deficiency    hemolytic-uremic syndrome    wegener's granulomatosis    thromboangiitis obliterans
    pulmonary emphysema    chronic obstructive pulmonary disease    lupus erythematosus    idiopathic pulmonary fibrosis
    bronchopulmonary dysplasia    emphysema    systemic lupus erythematosus    pulmonary fibrosis
    bronchitis    interstitial lung disease    pulmonary disease    cowpox
    pneumothorax    liver cirrhosis    vasculitis    angioedema

    10/15 Novoseek disease relationships for SERPINB1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pulmonary emphysema 72.8 4 2368980 (2), 8315277 (1), 10497394 (1)
    bronchoalveolar lavage fluid 59.1 6 7720229 (2), 9872847 (1), 7616758 (1), 12600833 (1)
    wegeners granulomatosis 50 1 1851056 (1)
    vasculitis 46 2 1655318 (1), 1851056 (1)
    psoriasis 36.8 2 1929539 (1), 2001428 (1)
    inflammation 36 6 1374264 (1), 1336720 (1), 12689923 (1), 1652455 (1) (see all 6)
    lung diseases 32 1 12162104 (1)
    pulmonary disease chronic obstructive 31.2 2 11889128 (1), 16596021 (1)
    bronchitis chronic 30 1 2368980 (1)
    pneumonia 18.3 7 12600833 (4), 18840548 (2), 2178530 (1)

    Human Genome Epidemiology (HuGE) Navigator: SERPINB1 (2 documents)

    Export disorders for SERPINB1 gene to outside databases

    Publications
    for SERPINB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINB1 gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with SERPINB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. (PubMed id 1376927)1, 2, 3 Remold-O'Donnell E.... Alberts M. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. (PubMed id 11747453)1, 2 Cooley J....Remold-O'Donnell E. (2001)
    6. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. (PubMed id 9630619)1, 2 Zeng W.... Remold-O'Donnell E. (1998)
    7. A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes. (PubMed id 7578269)1, 2 Packard B.Z.... Komoriya A. (1995)
    8. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    9. Serine protease inhibitor (SERPIN) B1 promotes oral c ancer cell motility and is over-expressed in invasive oral squamous cell carcin oma. (PubMed id 19213596)1, 9 Tseng M.Y....Chen J.Y. (2009)
    10. Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. (PubMed id 8530031)1, 9 Evans E....Remold-O'Donnell E. (1995)

    External Searches for SERPINB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SERPINB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1992 HGNC: 3311 AceView: SERPINB1 Ensembl:ENSG00000021355 euGenes: HUgn1992
    ECgene: SERPINB1 Kegg: 1992 H-InvDB: SERPINB1

    Other Databases showing SERPINB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SERPINB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINB1 gene:
    Search GeneIP for patents involving SERPINB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SERPINB1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SERPINB1   OriGene shRNA RFP for SERPINB1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINB1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINB1  
     OriGene Protein Over-expression Lysate for SERPINB1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SERPINB1   OriGene 3'-UTR Clone for SERPINB1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINB1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SERPINB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERPINB1   OriGene Custom Protein Services for SERPINB1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINB1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
     GenScript Custom Purified and Recombinant Proteins Services for SERPINB1 GenScript cDNA clones with any tag delivered in your preferred vector for SERPINB1
     GenScript Custom Assay Services for SERPINB1 GenScript Custom Superior Antibodies Services for SERPINB1
     GenScript Custom overexpressing Cell Line Services for SERPINB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERPINB1 promoter
     Search Chromatin IP Primers for SERPINB1
     RT2 qPCR Primer Assay in human, mouse, rat SERPINB1
     GNC Network for SERPINB1
     SABiosciences Custom PCR Arrays for SERPINB1
     Search Tocris compounds for SERPINB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERPINB1 antibodies
     SERPINB1 proteins
     SERPINB1 lysates
     Antibodies for SERPINB1
     See all of Abcam's Antibodies, Kits and Proteins for SERPINB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SERPINB1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SERPINB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINB1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SERPINB1
     SwitchGear Promoter luciferase reporter plasmids for SERPINB1
     Search ThermoFisher Antibodies for SERPINB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINB1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SERPINB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4