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SERPINB1 Gene

protein-coding   GIFtS: 61
GCID: GC06M002833

Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member...

(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin),...)
(Previous symbol: ELANH2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 11 2     PI-22 3
ELANH21 2 3 5     PI22 3
EI2 3 5     HEL572
Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 11 2     Epididymis Luminal Protein 572
Peptidase Inhibitor 22 3     Leukocyte Elastase Inhibitor2
LEI2 3     Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived2
M/NEI2 3     Monocyte/Neutrophil Elastase Inhibitor3
MNEI2 3     Serpin B13

External Ids:    HGNC: 33111   Entrez Gene: 19922   Ensembl: ENSG000000213557   OMIM: 1301355   UniProtKB: P307403   

Export aliases for SERPINB1 gene to outside databases

Previous GC identifers: GC06M002817 GC06M002778 GC06M002707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINB1 Gene:
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family
maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide
substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and
proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for SERPINB1 Gene:
SERPINB1 (serpin peptidase inhibitor, clade B (ovalbumin), member 1) is a protein-coding gene. Diseases associated with SERPINB1 include pulmonary disease, chronic obstructive, and thromboangiitis obliterans. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINE2.

UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H

Gene Wiki entry for SERPINB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINB1 gene promoter:
         TBP   NF-AT4   POU2F1   POU2F1a   STAT3   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINB1 promoter sequence
   Search Chromatin IP Primers for SERPINB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SERPINB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002833:  view genomic region     (about GC identifiers)

Start:
2,832,566 bp from pter      End:
2,842,240 bp from pter
Size:
9,675 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740 (See protein sequence)
Recommended Name: Leukocyte elastase inhibitor  
Size: 379 amino acids; 42742 Da
Subunit: Monomer
Sequence caution: Sequence=BAD97090.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SERPINB1:
4GA7 (3D)    
Secondary accessions: A8K5L2 Q53FB9 Q5W0E1 Q9UDF8

Explore the universe of human proteins at neXtProt for SERPINB1: NX_P30740

Explore proteomics data for SERPINB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys177, Lys196
  • Modification sites at PhosphoSitePlus

  • See SERPINB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_109591.1  
    ENSEMBL proteins: 
     ENSP00000370115   ENSP00000444543  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P30740

    ProtoNet protein and cluster: P30740

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: ILEU_HUMAN, P30740
    Domain: Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G,
    chymotrypsin, chymase or granzyme H, while reactive bond 2 is specific for reaction with elastase-like protease
    such as neutrophil elastase, proteinase-3, pancreatic elastase or PSA
    Similarity: Belongs to the serpin family. Ov-serpin subfamily


    SERPINB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILEU_HUMAN, P30740
    Function: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase,
    chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS1376927
         
    SERPINB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINB1:
     Decreased melanin production  Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serpinb1a):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    SERPINB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serpinb1atm1.1Cben for SERPINB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINB1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILEU_HUMAN, P30740: Cytoplasm (By similarity). Cytoplasmic granule
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    endoplasmic reticulum2
    nucleus2
    plasma membrane2
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    SERPINB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Amoebiasis
    Amoebiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SERPINB1):
        Amoebiasis


    SERPINB1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINB1
    Interactions:

        GeneGlobe Interaction Network for SERPINB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SERPINB1 (P307403 ENSP000003701154) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTN3P241583, ENSP000002343474I2D: score=3 STRING: ENSP00000234347
    AICDAQ9GZX73, ENSP000002293354I2D: score=1 STRING: ENSP00000229335
    CTSGP083113, ENSP000002163364I2D: score=1 STRING: ENSP00000216336
    ELANEP082463, ENSP000002636214I2D: score=4 STRING: ENSP00000263621
    RPS21P632203I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    SERPINB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINB1 (ILEU)

    7 Novoseek inferred chemical compound relationships for SERPINB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 40.5 4 19213596 (2), 18761000 (1)
    hydralazine 30 1 2168822 (1)
    superoxide 16.5 1 16595910 (1)
    heparin 10.5 4 7768918 (2), 12702549 (1), 7873546 (1)
    acetone 5.14 1 9257786 (1)
    h2o2 2.35 1 1334093 (1)
    calcium 0 4 9514602 (1), 12766385 (1), 8870026 (1)



    SERPINB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERPINB1 gene: 
    NM_030666.3  

    Unigene Cluster for SERPINB1:

    Serpin peptidase inhibitor, clade B (ovalbumin), member 1
    Hs.381167  [show with all ESTs]
    Unigene Representative Sequence: NR_073111
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380739(uc003mub.3) ENST00000468511 ENST00000490094 ENST00000476896
    ENST00000460260 ENST00000537185(uc021ykq.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat SERPINB1
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    Additional mRNA sequence: 

    AK223370.1 AK291327.1 AK298044.1 AK304641.1 AK309765.1 AK312973.1 BC009015.1 BT006928.1 
    M93056.1 NR_073111.1 NR_073112.1 

    15 DOTS entries:

    DT.215900  DT.97822870  DT.95364007  DT.100882285  DT.91639094  DT.100882257  DT.100882277  DT.100882282 
    DT.105586  DT.121406605  DT.75183304  DT.95364006  DT.95364008  DT.95364021  DT.121406595 

    Selected AceView cDNA sequences (see all 374):

    CR610741 BI789136 BM818915 AA593849 BM835546 BM826883 BX644204 NM_030666 
    BM021169 BM785367 AI433145 BM834115 BX110373 T29877 CB126476 CB145708 
    BM785872 BM822295 BM773487 BM785152 AW275821 CA305985 AL597159 BP350184 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ·
    SP1:                                      -     -     -                             -     -     -                                                               
    SP2:                                      -     -     -                             -     -                                                                     
    SP3:                                      -     -     -                       -     -     -     -                                                               
    SP4:                                      -     -     -                             -     -     -                       -                                       
    SP5:                                      -           -                             -     -     -                                                               

    ExUns: 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SERPINB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGATGCCCG
    SERPINB1 Expression
    About this image


    SERPINB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Kidney (Urinary System)
             S-shaped Body
    SERPINB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381167
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpinb1a1 , 5 serine (or cysteine) peptidase inhibitor, clade B, more1, 5 81.44(n)1
    80.47(a)1
      13 (13.75 cM)5
    662221  NM_025429.21  NP_079705.21 
     328420925 
    chicken
    (Gallus gallus)
    Aves SERPINB16
    serpin peptidase inhibitor, clade B (ovalbumin), m...
    69(a)
    1 ↔ 1
    2(67710614-67719508)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    65(a)
    60(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343311.1(763485-775454)
    GL343311.1(720723-751483)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257522 Xenopus laevis transcribed sequence with weak similarity more 74.87(n)    BJ628196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398415.12   -- 74.87(n)    AY398415.1 


    ENSEMBL Gene Tree for SERPINB1 (if available)
    TreeFam Gene Tree for SERPINB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINB1 gene
    SERPINE22  SERPINB72  SERPINI12  SERPINB52  SERPINB122  SERPINB62  SERPINI22  SERPINB22  
    SERPINC12  SERPINB102  SERPINB92  SERPINB32  SERPINE12  SERPINB112  SERPINE32  SERPINB42  
    SERPINB82  SERPINB132  
    Selected SIMAP similar genes for SERPINB1 using alignment to 2 protein entries:     ILEU_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O07189    SERPINB6    SERPINB9    SERPINB8    SERPINB5    SERPINB10
    SERPINB3    SERPINB13    AT3    DKFZp686D06190    SERPINB11    SERPINB12
    SERPINB2    SERPINB4    SCCA2    SERPINB7    SERPINI2    SERPINC1

    SERPINB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINB1 (see all 359)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3163631,2
    C,F,O,A,H--2832078(-) AGTCAA/GTTAAA 3 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 2715
    rs1834832811,2
    --2832091(+) AGAGGC/TCTGAG 3 -- ds50010--------
    rs1884178831,2
    C--2832094(+) GGCCTG/TAGGTA 3 -- ds50010--------
    rs1921539871,2
    --2832109(+) TTTCAC/TCATTA 3 -- ds50010--------
    rs121988091,2
    C,F,H--2832137(+) CCACAT/CAAAAT 3 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs598680911,2
    C--2832146(+) ATACGC/AATTGG 3 -- ds50014Minor allele frequency- A:0.16CSA WA EA 241
    rs1839698251,2
    --2832208(+) ACTTAC/TAGTCT 3 -- ds50010--------
    rs3163621,2
    C,F,A,H--2832331(-) CTCTTT/CTGGTT 3 -- ds500122Minor allele frequency- C:0.27NS EA NA CSA WA 2762
    rs1410583981,2
    C--2832349(+) CAGAA-/GGGCAG 3 -- ds50010--------
    rs3163611,2
    C,F,H--2832411(-) TTTTCC/TCCCGC 3 -- ds500115Minor allele frequency- T:0.02NS EA NA WA CSA 794

    HapMap Linkage Disequilibrium report for SERPINB1 (2832566 - 2842240 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SERPINB1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINB1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 130135    OMIM disorders: --

    Selected diseases for SERPINB1 (see all 49):    
    About MalaCards
    pulmonary disease, chronic obstructive    thromboangiitis obliterans    bronchitis    pulmonary emphysema
    alpha 1-antitrypsin deficiency    pneumothorax    wegener's granulomatosis    cowpox
    vasculitis    bronchiectasis    interstitial lung disease    hemolytic-uremic syndrome
    bronchopulmonary dysplasia    angioedema    idiopathic pulmonary fibrosis    urticaria
    burns    autoimmune thyroiditis    pulmonary fibrosis    pneumonia

    4 diseases from the University of Copenhagen DISEASES database for SERPINB1:
    Alpha 1-antitrypsin deficiency     Cowpox     Urticaria     Carcinoma

    SERPINB1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SERPINB1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pulmonary emphysema 72.8 4 2368980 (2), 8315277 (1), 10497394 (1)
    bronchoalveolar lavage fluid 59.1 6 7720229 (2), 9872847 (1), 7616758 (1), 12600833 (1)
    wegeners granulomatosis 50 1 1851056 (1)
    vasculitis 46 2 1655318 (1), 1851056 (1)
    psoriasis 36.8 2 1929539 (1), 2001428 (1)
    inflammation 36 6 1374264 (1), 1336720 (1), 12689923 (1), 1652455 (1) (see all 6)
    lung diseases 32 1 12162104 (1)
    pulmonary disease chronic obstructive 31.2 2 11889128 (1), 16596021 (1)
    bronchitis chronic 30 1 2368980 (1)
    pneumonia 18.3 7 12600833 (4), 18840548 (2), 2178530 (1)

    Genetic Association Database (GAD): SERPINB1
    Human Genome Epidemiology (HuGE) Navigator: SERPINB1 (2 documents)

    Export disorders for SERPINB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINB1 gene, integrated from 10 sources (see all 161):
    (articles sorted by number of sources associating them with SERPINB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. (PubMed id 1376927)1, 2, 3 Remold-O'Donnell E.... Alberts M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. (PubMed id 23269243)1, 2 Wang L.... Fan Z. (J. Immunol. 2013)
    3. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. (PubMed id 11747453)1, 2 Cooley J....Remold-O'Donnell E. (Biochemistry 2001)
    10. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene. (PubMed id 9630619)1, 2 Zeng W.... Remold-O'Donnell E. (Gene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1992 HGNC: 3311 AceView: SERPINB1 Ensembl:ENSG00000021355 euGenes: HUgn1992
    ECgene: SERPINB1 Kegg: 1992 H-InvDB: SERPINB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINB1 gene:
    Search GeneIP for patents involving SERPINB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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