Aliases for SERPINB1 Gene
External Ids for SERPINB1 Gene
Previous HGNC Symbols for SERPINB1 Gene
Previous GeneCards Identifiers for SERPINB1 Gene
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for SERPINB1 Gene
SERPINB1 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1) is a Protein Coding gene. Diseases associated with SERPINB1 include thromboangiitis obliterans and pulmonary disease, chronic obstructive. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.
UniProtKB/Swiss-Prot for SERPINB1 Gene
Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.