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Aliases for SERPINA9 Gene

Aliases for SERPINA9 Gene

  • Serpin Family A Member 9 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Germinal Center B-Cell-Expressed Transcript 1 Protein 3 4
  • SERPINA11 3 4
  • Centerin 3 4
  • GCET1 3 4
  • Serine Proteinase Inhibitor A11 3
  • SERPINA11b 3
  • Serpin A9 3

External Ids for SERPINA9 Gene

Previous GeneCards Identifiers for SERPINA9 Gene

  • GC00U991020
  • GC14M092920
  • GC14M093998
  • GC14M094929
  • GC14M075109

Summaries for SERPINA9 Gene

GeneCards Summary for SERPINA9 Gene

SERPINA9 (Serpin Family A Member 9) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA7.

UniProtKB/Swiss-Prot for SERPINA9 Gene

  • Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Wiki entry for SERPINA9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA9 Gene

Genomics for SERPINA9 Gene

Regulatory Elements for SERPINA9 Gene

Enhancers for SERPINA9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F094382 1.5 FANTOM5 Ensembl ENCODE 10.9 +88.9 88883 16.9 PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 FOS PAF1 SP5 ZHX2 SERPINA1 IFI27L2 SERPINA11 SERPINA9 ENSG00000256357 SERPINA2
GH14F094373 1.2 FANTOM5 Ensembl ENCODE 10.7 +105.2 105227 2.8 SAP130 BHLHE40 REST RAD21 ZBTB40 TEAD3 JUND ATF3 POLR2A FOS ENSG00000256357 SERPINA9 SERPINA2 SERPINA1
GH14F094413 0.2 ENCODE 10.6 +66.6 66551 0.2 SOX13 CTCF SAP130 ARID4B RAD21 GATAD1 ZNF143 SMC3 MIXL1 GATAD2A SERPINA1 SERPINA9 SERPINA11 ENSG00000256357
GH14F094412 0.4 Ensembl 10.6 +67.0 66988 0.6 SOX13 GATAD2A ZNF654 KLF6 MNT RAD21 SSRP1 MIER3 KLF16 GATAD1 SERPINA1 SERPINA9 SERPINA11 ENSG00000256357
GH14F094415 0.3 FANTOM5 10.6 +64.4 64435 0.2 CTCF SERPINA1 SERPINA9 SERPINA11 ENSG00000256357
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERPINA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINA9 Gene

Chromosome:
14
Start:
94,462,717 bp from pter
End:
94,479,689 bp from pter
Size:
16,973 bases
Orientation:
Minus strand

Genomic View for SERPINA9 Gene

Genes around SERPINA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA9 Gene

Proteins for SERPINA9 Gene

  • Protein details for SERPINA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WD7-SPA9_HUMAN
    Recommended name:
    Serpin A9
    Protein Accession:
    Q86WD7
    Secondary Accessions:
    • B4DVH4
    • B9ZVX3
    • Q2T9J2
    • Q6UWP9
    • Q86WD4
    • Q86WD5
    • Q86WD6
    • Q86YP6
    • Q86YP7

    Protein attributes for SERPINA9 Gene

    Size:
    417 amino acids
    Molecular mass:
    46557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO32345.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SERPINA9 Gene

neXtProt entry for SERPINA9 Gene

Post-translational modifications for SERPINA9 Gene

  • Glycosylation at Asn 101 and Asn 390
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SERPINA9 Gene

Domains & Families for SERPINA9 Gene

Gene Families for SERPINA9 Gene

Protein Domains for SERPINA9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WD7

UniProtKB/Swiss-Prot:

SPA9_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA9: view

Function for SERPINA9 Gene

Molecular function for SERPINA9 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Ontology (GO) - Molecular Function for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 15489334
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA9: view
genes like me logo Genes that share phenotypes with SERPINA9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINA9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA9 Gene

Localization for SERPINA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA9 Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA9 Gene COMPARTMENTS Subcellular localization image for SERPINA9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

Pathways & Interactions for SERPINA9 Gene

SuperPathways for SERPINA9 Gene

No Data Available

Interacting Proteins for SERPINA9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337133%0d%0a9606.ENSP00000053867%0d%0a
Selected Interacting proteins: Q86WD7-SPA9_HUMAN ENSP00000337133 for SERPINA9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA9 Gene

Transcripts for SERPINA9 Gene

Unigene Clusters for SERPINA9 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SERPINA9 Gene

GeneLoc Exon Structure for
SERPINA9
ECgene alternative splicing isoforms for
SERPINA9

Expression for SERPINA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERPINA9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.0) and Skin - Sun Exposed (Lower leg) (x17.8).

NURSA nuclear receptor signaling pathways regulating expression of SERPINA9 Gene:

SERPINA9

SOURCE GeneReport for Unigene cluster for SERPINA9 Gene:

Hs.317970

mRNA Expression by UniProt/SwissProt for SERPINA9 Gene:

Q86WD7-SPA9_HUMAN
Tissue specificity: Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.
genes like me logo Genes that share expression patterns with SERPINA9: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SERPINA9 Gene

Orthologs for SERPINA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA9 34 35
  • 97.93 (n)
dog
(Canis familiaris)
Mammalia SERPINA9 34 35
  • 81.57 (n)
rat
(Rattus norvegicus)
Mammalia Serpina9 34
  • 76.87 (n)
mouse
(Mus musculus)
Mammalia Serpina9 16 35 34
  • 74.84 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:174259 34
  • 49.77 (n)
Species where no ortholog for SERPINA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA9 Gene

ENSEMBL:
Gene Tree for SERPINA9 (if available)
TreeFam:
Gene Tree for SERPINA9 (if available)

Paralogs for SERPINA9 Gene

Variants for SERPINA9 Gene

Sequence variations from dbSNP and Humsavar for SERPINA9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1002520 -- 94,477,297(+) TACTC(A/T)CGGTT upstream-variant-2KB
rs10130707 -- 94,465,936(+) TGACT(C/T)ACAGC intron-variant
rs10137789 -- 94,468,524(+) CAGCA(C/T)AGAGA intron-variant
rs10146263 -- 94,476,054(+) acact(A/G)aagac intron-variant, utr-variant-5-prime
rs10149610 -- 94,477,088(+) AGTTT(A/G)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINA9 Gene

Variant ID Type Subtype PubMed ID
esv2760010 CNV loss 17122850
nsv1407 CNV insertion 18451855
nsv470662 CNV gain 18288195
nsv510649 CNV deletion 20534489
nsv565623 CNV gain 21841781
nsv832863 CNV gain 17160897
nsv832864 CNV loss 17160897

Variation tolerance for SERPINA9 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.03; 96.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA9 Gene

Disorders for SERPINA9 Gene

Relevant External Links for SERPINA9

Genetic Association Database (GAD)
SERPINA9
Human Genome Epidemiology (HuGE) Navigator
SERPINA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINA9

No disorders were found for SERPINA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINA9 Gene

Publications for SERPINA9 Gene

  1. Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. (PMID: 17898315) Montes-Moreno S. … Piris M.A. (Blood 2008) 3 4 22 64
  2. Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas. (PMID: 18550480) Paterson M.A. … Coughlin P.B. (Am. J. Clin. Pathol. 2008) 3 4 22 64
  3. Molecular characterization of centerin, a germinal centre cell serpin. (PMID: 17447896) Paterson M.A. … Coughlin P.B. (Biochem. J. 2007) 3 4 22 64
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3 64
  5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64

Products for SERPINA9 Gene

Sources for SERPINA9 Gene

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