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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERPINA7 Gene

protein-coding GIFtS: 57
GCID: GC0XM105277

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
(Previous symbol: TBG)

Explore 61 diseases affiliated with
SERPINA7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7¹ ²		T4-Binding Globulin² ³
TBG¹ ² ³ ⁵		Thyroxin-Binding Globulin²
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7¹ ²		Thyroxine-Binding Globulin²
Serpin A7² ³

External Ids:	HGNC: 11583¹	Entrez Gene: 6906²	Ensembl: ENSG00000123561⁷	OMIM: 314200⁵	UniProtKB: P05543³

Export aliases for SERPINA7 gene to outside databases

Previous GC identifers: GC0XM100589 GC0XM102196 GC0XM103310 GC0XM104049 GC0XM105083 GC0XM094904

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINA7:

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying

the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major

thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no

inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency,

which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG.

Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of

these variants has not been determined.(provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Function: Major thyroid hormone transport protein in serum

Gene Wiki entry for SERPINA7 (Thyroxine-binding globulin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERPINA7 gene promoter:
Pbx1a FOXO3 CUTL1 Nkx2-5 HNF-1A FOXO3b POU2F1 POU2F1a IRF-7A FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINA7 promoter sequence

Search SABiosciences Chromatin IP Primers for SERPINA7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq21-q22

SERPINA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA7 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM105277: view genomic region (about GC identifiers)

Start:	105,277,190 bp from pter	End:	105,282,729 bp from pter
Size:	5,540 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543 (See protein sequence)

Recommended Name: Thyroxine-binding globulin precursor

Size: 415 amino acids; 46325 Da

Subcellular location: Secreted

6/7 PDB 3D structures from and Proteopedia for SERPINA7 (see all 7):

2CEO (3D)

2RIV (3D)

2RIW (3D)

2XN3 (3D)

2XN5 (3D)

2XN6 (3D)

Secondary accessions: D3DUX1

Explore the universe of human proteins at neXtProt for SERPINA7: NX_P05543

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05543

SERPINA7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000345.2

ENSEMBL proteins:

ENSP00000329374 ENSP00000361644

Human Recombinant Protein Products:

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	Uscn Proteins for SERPINA7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IEA	--

SERPINA7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SERPINA7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERPINA7 for domains About GeneDecksing

4 InterPro domains/families:

IPR000295 Prot_inh_Lserp2

IPR023795 Protease_inhib_I4_serpin_CS

IPR023796 Serpin_dom

IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry P05543

ProtoNet protein and cluster: P05543

1 Blocks protein family: IPB000215 Serpin

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Similarity: Belongs to the serpin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Function: Major thyroid hormone transport protein in serum

miRNA Products:		OriGene 3'-UTR Clone: SERPINA7 Browse MicroRNA Expression Plasmids
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		hsa-miR-1261
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA7

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	--
GO:0005488	binding	--	--
GO:0042562	hormone binding	IEA	--

SERPINA7 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SERPINA7

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SERPINA7 (P05543³ ENSP00000329374⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC16A2	P36021³, ENSP00000276033⁴	I2D: score=1 STRING: ENSP00000276033

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007568	aging	IEA	--
GO:0009791	post-embryonic development	IEA	--
GO:0010951	negative regulation of endopeptidase activity	IBA	--
GO:0030162	regulation of proteolysis	IBA	--
GO:0031667	response to nutrient levels	--	--

SERPINA7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SERPINA7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERPINA7

2 HMDB Compounds for SERPINA7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Liothyronine	3,3',5-Triiodo-L-thyronine (see all 20)	6893-02-3	--
Thyroxine	(-)-Thyroxine (see all 33)	51-48-9	--

3 DrugBank Compounds for SERPINA7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Levothyroxine	(-)-Thyroxine (see all 13)	51-48-9	carrier	--	12553433
Liothyronine	L-Liothyronine (see all 5)	6893-02-3	carrier	--	12553433
Liotrix	--	8065-29-0	carrier	--	12553433

10/64 Novoseek chemical compound relationships for SERPINA7 gene (see all 64) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroxine	93.7	1061	8039542 (8), 1623594 (7), 8319367 (7), 9219796 (6) (see all 99)
triiodothyronine	90.3	355	8042912 (4), 9357931 (4), 8048729 (3), 1899469 (3) (see all 99)
t4 sulfate	82.1	6	15292353 (2), 15181064 (1)
iodine	56.9	21	8451907 (3), 1328820 (2), 7750195 (2), 10052168 (1) (see all 9)
iodide	44.3	3	10718550 (1), 1424182 (1), 10585360 (1)
diflunisal	40.5	4	8231843 (1), 15080795 (1)
testosterone	31.5	32	16793944 (3), 7518657 (2), 19170715 (2), 9039510 (2) (see all 14)
estradiol	30.3	10	1923289 (1), 16793944 (1), 2127845 (1), 1360737 (1) (see all 8)
estrogen	29.2	26	11095487 (3), 16793944 (1), 18167471 (1), 11396440 (1) (see all 13)
serine	29.2	26	11555848 (3), 11095421 (2), 16735497 (1), 11889191 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about SERPINA7 / THBG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINA7 gene:

NM_000354.5

Unigene Cluster for SERPINA7:

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

Hs.76838 [show with all ESTs]

Unigene Representative Sequence: M14091

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000327674(uc010npd.3) ENST00000372563(uc004eme.2 uc010npe.2)

ENST00000487487

miRNA Products:		OriGene 3'-UTR Clone: SERPINA7 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-1261
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Additional cDNA sequence:

BC020747.2 M14091.1

5 DOTS entries:

DT.100778570 DT.91678164 DT.115742 DT.91678167 DT.115740

24/51 AceView cDNA sequences (see all 51):

CB154708 M31218 CB156954 CB164769 BC020747 CB161522 AV688732 BU602793

AA699570 BG568908 AI217595 H59313 M14091 CD608228 BV204000 NM_000354

AV682096 CB142745 BQ651744 CB162284 AV687836 R91812 H59266 H67382

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA7 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c
SP1:									-
SP2:

ECgene alternative splicing isoforms for SERPINA7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTGATTT

About this image
See SERPINA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERPINA7

SOURCE GeneReport for Unigene cluster: Hs.76838

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Tissue specificity: Expressed by the liver and secreted in plasma

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINA7 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	zgc:174260⁶ serpina1⁶ (see all 8)	zgc:174260 serine (or cysteine) proteinase inhibitor, clade A... (see all 8)	37(a) 35(a) (see all 8)	many ↔ many many ↔ many (see all 8)	5(30450534-30456663) 20(10732283-10734497)
fruit fly (Drosophila melanogaster)	Insecta	Spn100A⁶ Spn3⁶ (see all 26)	Serine protease inhibitor 3 (see all 26)	9(a) 27(a) (see all 26)	possible ortholog possible ortholog (see all 26)	3R(26516366-26518490) 2L(20836621-20838179)
worm (Caenorhabditis elegans)	Secernentea	srp-2⁶ srp-1⁶ (see all 6)	SeRPin family member (srp-1) (see all 6)	26(a) 24(a) (see all 6)	possible ortholog possible ortholog (see all 6)	V(762735-764658) V(753335-755049)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25240⁶ AT1G64010⁶ (see all 10)	serine protease inhibitor-like protein (see all 10)	22(a) 22(a) (see all 10)	many ↔ many many ↔ many (see all 10)	2(10751768-10753134) 1(23750884-23751441)
rice (Oryza sativa)	Liliopsida	-- -- (see all 16)	serpin domain containing protein, putative (see all 16)	23(a) 22(a) (see all 16)	many ↔ many many ↔ many (see all 16)	3(23053071-23066803) 5(25288055-25288993)

ENSEMBL Gene Tree for SERPINA7 (if available)
TreeFam Gene Tree for SERPINA7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERPINA7 gene

SERPING1² SERPINA1² SERPINH1² SERPINA10² SERPINA11² SERPINA12² SERPINA9² SERPINA5²

SERPINF1² SERPIND1² SERPINA4² SERPINA3² SERPINA6² SERPINF2²

18/27 SIMAP similar genes for SERPINA7 using alignment to 1 protein entry: THBG_HUMAN(see all similar genes):

SERPINA9 SERPINA11 SERPINA1 SERPINA3 SERPINA6 SERPINA4

SERPINA5 SERPINA12 SERPINA2P SERPINA13P SERPINB3 SERPINI1

SERPINB5 SERPINB6 SERPINB9 SERPINI2 SERPIND1 SERPINA10

SERPINA7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SERPINA7
PGOHUM00000241493

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Polymorphism: Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian

aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by

heat or acid. TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians

and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28933689^1,2	C	pathogenic	95302712(-)	`TCTGAT/ACTGTT`	2	/N /I	mis¹		2		NA	4
rs1050086^1,2	C,F,H,	pathogenic	95302936(-)	`TTCAAA/GACCTC`	2	N D	mis¹ ese³		11		MN NS EA NA	5650
rs1804495^1,2	C,F,O,H,	pathogenic	95305054(-)	`GACTTT/GTTTGT`	2	/L /F	mis¹ ese³		24		NA NS EA WA	7088
rs61754490^1,2	C,F,	pathogenic	95305131(-)	`TGCCTA/TTTCTG`	2	Y F	mis¹		1		NA	4544
rs72554659^1,2	C	pathogenic	95305756(-)	`CTGCCC/TATAAG`	2	H Y	mis¹		0	--	--	--	--
rs72554658^1,2	C	pathogenic	95305853(-)	`ACACCC/TTATTA`	2	P L	mis¹		0	--	--	--	--
rs2234040^1,2	C,H	--	94904504(-)	`CTTTCC/TTACAC`	2	L	syn¹ ese³		6		NS EA NA	602
rs73517294^1,2	C,	--	94905568(+)	`CCCTGG/AGGTGA`	1	--	int¹		4		WA CSA	5
rs17332369^1,2	C,F,H,	--	94905700(+)	`CAACCA/TGTTCT`	1	--	int¹		13	--	NA NS EA	1216
rs2234038^1,2	C,F,H,	--	94905965(-)	`GAAACC/TCAGAG`	1	--	int¹		4		NS EA	420

HapMap Linkage Disequilibrium report for SERPINA7 (105277190 - 105282729 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SERPINA7
1 CNV: 8310
Human Gene Mutation Database (HGMD): SERPINA7

Locus Specific Mutation Databases (LSDB): SERPINA7

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SERPINA7 for disorders About GeneDecksing

OMIM gene information: 314200 OMIM disorders: --

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543

Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200].

Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or

increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are

euthyroid

20/61 diseases for SERPINA7 (see all 61): About MalaCards

thyroxine-binding globulin deficiency thyroiditis spinal cord injury dysalbuminemic hyperthyroxinemia

placental insufficiency hyperthyroxinemia euthyroid sick syndrome endemic goiter

growth hormone deficiency duchenne muscular dystrophy muscular dystrophy iron overload

congenital hypothyroidism bulimia nervosa hypothyroidism turner syndrome

pituitary adenoma goiter liver cirrhosis acquired immunodeficiency syndrome

7 diseases from the University of Copenhagen DISEASES database for SERPINA7:

Hyperthyroxinemia Hypothyroidism Hyperthyroidism Thyrotoxicosis

Goiter Euthyroid sick syndrome Thyroiditis

10/50 Novoseek disease relationships for SERPINA7 gene (see all 50) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tbg, serum	97.4	92	1689951 (6), 9219796 (5), 2129300 (3), 8365361 (3) (see all 36)
hyperthyroxinemia	88.8	22	2108434 (2), 1849117 (1), 1422238 (1), 8964573 (1) (see all 8)
low t3 syndrome	80.5	2	11544736 (1)
hypothyroidism	74.4	21	10429016 (2), 1700701 (1), 8345439 (1), 7947028 (1) (see all 13)
hyperthyroidism	71.5	16	7647413 (2), 8042912 (1), 18167471 (1), 8475674 (1) (see all 12)
thyroid diseases	65.5	2	7518657 (1), 19675882 (1)
cdg ia	63.5	2	8530628 (1), 9516657 (1)
hypothyroidism primary	62.5	1	14751039 (1)
congenital hypothyroidism	61.6	10	7635701 (1), 15858240 (1), 10429016 (1), 11533748 (1) (see all 7)
thyroid hormone resistance	61.2	2	14517508 (1)

Export disorders for SERPINA7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SERPINA7 gene, integrated from 9 sources (see all 397):
(articles sorted by number of sources associating them with SERPINA7)

Utopia: connect your pdf to the dynamic
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Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect. (PubMed id 2155256)^{1, 2, 9} Mori Y.... Refetoff S. (1990)
Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family. (PubMed id 1294376)^{1, 2, 9} Shirotani T.... Shichiri M. (1992)
The structure of the human thyroxine binding globulin (TBG) gene. (PubMed id 8268226)^{1, 2, 9} Akbari M.T.... Ramsden D.B. (1993)
Sequencing of the variant thyroxine-binding globulin (TBG)-San Diego reveals two nucleotide substitutions. (PubMed id 1515456)^{1, 2, 9} Bertenshaw R.... Refetoff S. (1992)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation. (PubMed id 8232304)^{1, 2} Hayashi Y.... Refetoff S. (1993)
Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. (PubMed id 1901689)^{1, 2} Bertenshaw R.... Refetoff S. (1991)
Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency. (PubMed id 1906047)^{1, 2} Janssen O.E.... Refetoff S. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6906	HGNC: 11583	AceView: SERPINA7	Ensembl:ENSG00000123561	euGenes: HUgn6906
ECgene: SERPINA7	H-InvDB: SERPINA7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SERPINA7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERPINA7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERPINA7 gene:
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GeneCards and IP:
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TBG, SERUM
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PITUITARY ADENOMA
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THYROID HORMONE RESISTANCE
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