Aliases for SERPINA7 Gene
External Ids for SERPINA7 Gene
Previous HGNC Symbols for SERPINA7 Gene
Previous GeneCards Identifiers for SERPINA7 Gene
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
GeneCards Summary for SERPINA7 Gene
SERPINA7 (Serpin Family A Member 7) is a Protein Coding gene. Diseases associated with SERPINA7 include thyroxine-binding globulin deficiency and congenital isolated thyroxine-binding globulin deficiency. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and hormone binding. An important paralog of this gene is SERPINA11.
UniProtKB/Swiss-Prot for SERPINA7 Gene
Major thyroid hormone transport protein in serum.