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SERPINA7 Gene

protein-coding   GIFtS: 58
GCID: GC0XM105277

Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
(Previous symbol: TBG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 71 2
     Serpin A72 3
TBG1 2 3 5     T4-Binding Globulin2 3
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1
Antiproteinase, Antitrypsin), Member 71 2
     Alpha-1 Antiproteinase1
Thyroxin-Binding Globulin1 2     antitrypsin1
Thyroxine-Binding Globulin1 2     

External Ids:    HGNC: 115831   Entrez Gene: 69062   Ensembl: ENSG000001235617   OMIM: 3142005   UniProtKB: P055433   

Export aliases for SERPINA7 gene to outside databases

Previous GC identifers: GC0XM100589 GC0XM102196 GC0XM103310 GC0XM104049 GC0XM105083 GC0XM094904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SERPINA7 Gene:
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for
carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene
encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics,
but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene
result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based
on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found,
but the full-length nature of these variants has not been determined.(provided by RefSeq, Jun 2012)

GeneCards Summary for SERPINA7 Gene:
SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7) is a protein-coding gene. Diseases associated with SERPINA7 include placental insufficiency, and thyroxine-binding globulin deficiency. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and hormone binding. An important paralog of this gene is SERPING1.

UniProtKB/Swiss-Prot: THBG_HUMAN, P05543
Function: Major thyroid hormone transport protein in serum

Gene Wiki entry for SERPINA7 (Thyroxine-binding globulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINA7 gene promoter:
         Pbx1a   FOXO3   CUTL1   Nkx2-5   HNF-1A   FOXO3b   POU2F1   POU2F1a   IRF-7A   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINA7 promoter sequence
   Search Chromatin IP Primers for SERPINA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq21-q22

SERPINA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM105277:  view genomic region     (about GC identifiers)

Start:
105,277,190 bp from pter      End:
105,282,729 bp from pter
Size:
5,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THBG_HUMAN, P05543 (See protein sequence)
Recommended Name: Thyroxine-binding globulin precursor  
Size: 415 amino acids; 46325 Da
Selected PDB 3D structures from and Proteopedia for SERPINA7 (see all 7):
2CEO (3D)        2RIV (3D)        2RIW (3D)        2XN3 (3D)        2XN5 (3D)        2XN6 (3D)    
Secondary accessions: D3DUX1

Explore the universe of human proteins at neXtProt for SERPINA7: NX_P05543

Explore proteomics data for SERPINA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn99, Ile116, Asn165, Asn253
  • Modification sites at PhosphoSitePlus

  • See SERPINA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000345.2  
    ENSEMBL proteins: 
     ENSP00000329374   ENSP00000361644  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    3 InterPro protein domains:
     IPR023795 Serpin_CS
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry P05543

    ProtoNet protein and cluster: P05543

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: THBG_HUMAN, P05543
    Similarity: Belongs to the serpin family


    SERPINA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THBG_HUMAN, P05543
    Function: Major thyroid hormone transport protein in serum

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0042562hormone binding IEA--
         
    SERPINA7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINA7
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    1 qRT-PCR Assays for microRNA that regulate SERPINA7:
    hsa-miR-1261
    SwitchGear 3'UTR luciferase reporter plasmidSERPINA7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THBG_HUMAN, P05543: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    SERPINA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINA7
    Interactions:

        Search GeneGlobe Interaction Network for SERPINA7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SERPINA7 (P055433 ENSP000003293744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC16A2P360213, ENSP000002760334I2D: score=1 STRING: ENSP00000276033
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007568aging IEA--
    GO:0009791post-embryonic development IEA--
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0031667response to nutrient levels ----

    SERPINA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINA7 (THBG)

    2 HMDB Compounds for SERPINA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--
    Thyroxine(-)-Thyroxine (see all 33)51-48-9--

    3 DrugBank Compounds for SERPINA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9carrier--12553433
    LiothyronineL-Liothyronine (see all 5)6893-02-3carrier--12553433
    Liotrix-- 8065-29-0carrier--12553433

    Selected Novoseek inferred chemical compound relationships for SERPINA7 gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroxine 93.7 1061 8039542 (8), 1623594 (7), 8319367 (7), 9219796 (6) (see all 99)
    triiodothyronine 90.3 355 8042912 (4), 9357931 (4), 8048729 (3), 1899469 (3) (see all 99)
    t4 sulfate 82.1 6 15292353 (2), 15181064 (1)
    iodine 56.9 21 8451907 (3), 1328820 (2), 7750195 (2), 10052168 (1) (see all 9)
    iodide 44.3 3 10718550 (1), 1424182 (1), 10585360 (1)
    diflunisal 40.5 4 8231843 (1), 15080795 (1)
    testosterone 31.5 32 16793944 (3), 7518657 (2), 19170715 (2), 9039510 (2) (see all 14)
    estradiol 30.3 10 1923289 (1), 16793944 (1), 2127845 (1), 1360737 (1) (see all 8)
    estrogen 29.2 26 11095487 (3), 16793944 (1), 18167471 (1), 11396440 (1) (see all 13)
    serine 29.2 26 11555848 (3), 11095421 (2), 16735497 (1), 11889191 (1) (see all 13)



    SERPINA7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERPINA7 gene: 
    NM_000354.5  

    Unigene Cluster for SERPINA7:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
    Hs.76838  [show with all ESTs]
    Unigene Representative Sequence: M14091
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327674(uc010npd.3) ENST00000372563(uc004eme.2 uc010npe.2)
    ENST00000487487
    miRNA
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    hsa-miR-1261
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC020747.2 M14091.1 

    5 DOTS entries:

    DT.100778570  DT.91678164  DT.115742  DT.91678167  DT.115740 

    Selected AceView cDNA sequences (see all 51):

    CB161522 CB156954 CB164769 M31218 CB154708 BC020747 BG568908 BU602793 
    M14091 H59313 BV204000 AV688732 CD608228 AV682096 BQ651744 AI217595 
    CB142745 NM_000354 CB162284 AA699570 H67382 AW965009 R92276 H59266 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                          -               
    SP2:                                          


    ECgene alternative splicing isoforms for SERPINA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGATTT
    SERPINA7 Expression
    About this image


    SERPINA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Spleen (Hematopoietic System)
    SERPINA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76838

    UniProtKB/Swiss-Prot: THBG_HUMAN, P05543
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINA7 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpina71 , 5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 more1, 5 81.8(n)1
    76.57(a)1
      X (61.23 cM)5
    3315351  NM_177920.51  NP_808588.31 
     1390792575 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.112712 Oncorhynchus mykiss mRNA for alpha-1-antiproteinase-like more 74.86(n)    AJ558113.1 


    ENSEMBL Gene Tree for SERPINA7 (if available)
    TreeFam Gene Tree for SERPINA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINA7 gene
    SERPING12  SERPINA12  SERPINA102  SERPINA112  SERPINA122  SERPINA92  SERPINF12  SERPINA52  
    SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
    Selected SIMAP similar genes for SERPINA7 using alignment to 1 protein entry:     THBG_HUMAN(see all similar genes):
    SERPINA9    SERPINA11    SERPINA1    SERPINA3    SERPINA6    SERPINA4
    SERPINA5    SERPINA12    SERPINA2    SERPINA2P    SERPINA13P    SERPINB3
    SERPINI1    SERPINB5    SERPINB6    SERPINB9    SERPINI2    SERPIND1

    SERPINA7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINA7
    PGOHUM00000241493


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    THBG_HUMAN, P05543: Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian
    aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to
    inactivation by heat or acid. TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos,
    Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile


    Selected SNPs for SERPINA7 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289373121,2,,4
    CThyroxine-binding globulin deficiency (TBG deficiency)4 pathogenic1105248861(-) TCACCC/TAGTGG 2 P L mis1 ese30--------
    rs289336881,2,,4
    CThyroxine-binding globulin deficiency (TBG deficiency)4 pathogenic1105250255(-) GAAATC/GCCCTC 2 P A mis10--------
    rs289336891,2,,4
    CThyroxine-binding globulin deficiency (TBG deficiency)4 pathogenic1105250305(-) TCTGAA/TCTGTT 2 N I mis10--------
    VAR_0071094
    Thyroxine-binding globulin deficiency (TBG deficiency)4--see VAR_0071092 H Y mis40--------
    VAR_0071024
    Thyroxine-binding globulin deficiency (TBG deficiency)4--see VAR_0071022 S T mis40--------
    VAR_0071104
    Thyroxine-binding globulin deficiency (TBG deficiency)4--see VAR_0071102 P L mis40--------
    rs725546581,2
    Cpathogenic1105247193(-) ACACCC/TTATTA 2 P L mis10--------
    rs725546591,2
    Cpathogenic1105247290(-) CTGCCC/TATAAG 2 H Y mis10--------
    rs617544901,2
    C,Fpathogenic1105247886(-) TGCCTA/TTTCTG 2 Y F mis11Minor allele frequency- T:0.00NA 4544
    rs18044951,2,,4
    C,F,O,Hpathogenic1105247963(-) GACTTT/GTTTGT 2 /L /F mis1 ese324Minor allele frequency- G:0.85NA NS EA WA 7088

    HapMap Linkage Disequilibrium report for SERPINA7 (105277190 - 105282729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SERPINA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7022CNV Insertion18451855
    esv2752312CNV Gain17911159
    nsv521259CNV Gain19592680
    nsv528467CNV Gain19592680

    Human Gene Mutation Database (HGMD): SERPINA7
    Locus Specific Mutation Databases (LSDB): SERPINA7

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 314200    OMIM disorders: --

    UniProtKB/Swiss-Prot: THBG_HUMAN, P05543
  • Thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]: Mutations in the SERPINA7 gene can
    result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum.
    Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for SERPINA7 (see all 59):    
    About MalaCards
    placental insufficiency    thyroxine-binding globulin deficiency    transsexualism    congenital isolated thyroxine-binding globulin deficiency
    thyroid agenesis    dysalbuminemic hyperthyroxinemia    hyperthyroidism    hyperthyroxinemia
    euthyroid sick syndrome    endemic goiter    acquired immunodeficiency syndrome    turner syndrome
    breast cyst    thyrotoxicosis    thyroid adenoma    goiter
    hypothyroidism    congenital hypothyroidism    duchenne muscular dystrophy    bulimia nervosa

    7 diseases from the University of Copenhagen DISEASES database for SERPINA7:
    Hyperthyroxinemia     Hypothyroidism     Hyperthyroidism     Thyrotoxicosis
    Goiter     Euthyroid sick syndrome     Thyroiditis

    SERPINA7 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SERPINA7 gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbg, serum 97.4 92 1689951 (6), 9219796 (5), 2129300 (3), 8365361 (3) (see all 36)
    hyperthyroxinemia 88.8 22 2108434 (2), 1849117 (1), 1422238 (1), 8964573 (1) (see all 8)
    low t3 syndrome 80.5 2 11544736 (1)
    hypothyroidism 74.4 21 10429016 (2), 1700701 (1), 8345439 (1), 7947028 (1) (see all 13)
    hyperthyroidism 71.5 16 7647413 (2), 8042912 (1), 18167471 (1), 8475674 (1) (see all 12)
    thyroid diseases 65.5 2 7518657 (1), 19675882 (1)
    cdg ia 63.5 2 8530628 (1), 9516657 (1)
    hypothyroidism primary 62.5 1 14751039 (1)
    congenital hypothyroidism 61.6 10 7635701 (1), 15858240 (1), 10429016 (1), 11533748 (1) (see all 7)
    thyroid hormone resistance 61.2 2 14517508 (1)


    Export disorders for SERPINA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINA7 gene, integrated from 10 sources (see all 401):
    (articles sorted by number of sources associating them with SERPINA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect. (PubMed id 2155256)1, 2, 9 Mori Y.... Refetoff S. (J. Clin. Endocrinol. Metab. 1990)
    2. Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family. (PubMed id 1294376)1, 2, 9 Shirotani T.... Shichiri M. (Endocrinol. Jpn. 1992)
    3. The structure of the human thyroxine binding globulin (TBG) gene. (PubMed id 8268226)1, 2, 9 Akbari M.T.... Ramsden D.B. (Biochim. Biophys. Acta 1993)
    4. Sequencing of the variant thyroxine-binding globulin (TBG)-San Diego reveals two nucleotide substitutions. (PubMed id 1515456)1, 2, 9 Bertenshaw R.... Refetoff S. (Biochim. Biophys. Acta 1992)
    5. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation. (PubMed id 8232304)1, 2 Hayashi Y.... Refetoff S. (Mol. Endocrinol. 1993)
    10. Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. (PubMed id 1901689)1, 2 Bertenshaw R.... Refetoff S. (Am. J. Hum. Genet. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6906 HGNC: 11583 AceView: SERPINA7 Ensembl:ENSG00000123561 euGenes: HUgn6906
    ECgene: SERPINA7 H-InvDB: SERPINA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINA7 gene:
    Search GeneIP for patents involving SERPINA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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