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Aliases for SERPINA7 Gene

Aliases for SERPINA7 Gene

  • Serpin Family A Member 7 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 2 3
  • Thyroxin-Binding Globulin 2 3
  • T4-Binding Globulin 3 4
  • Serpin A7 3 4
  • TBG 3 4
  • Thyroxine-Binding Globulin 2
  • Alpha-1 Antiproteinase 2
  • Antitrypsin 2

External Ids for SERPINA7 Gene

Previous HGNC Symbols for SERPINA7 Gene

  • TBG

Previous GeneCards Identifiers for SERPINA7 Gene

  • GC0XM100589
  • GC0XM102196
  • GC0XM103310
  • GC0XM104049
  • GC0XM105083
  • GC0XM105277
  • GC0XM094904

Summaries for SERPINA7 Gene

Entrez Gene Summary for SERPINA7 Gene

  • There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

GeneCards Summary for SERPINA7 Gene

SERPINA7 (Serpin Family A Member 7) is a Protein Coding gene. Diseases associated with SERPINA7 include Thyroxine-Binding Globulin Deficiency and Congenital Isolated Thyroxine-Binding Globulin Deficiency. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and hormone binding. An important paralog of this gene is SERPINA11.

UniProtKB/Swiss-Prot for SERPINA7 Gene

  • Major thyroid hormone transport protein in serum.

Gene Wiki entry for SERPINA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA7 Gene

Genomics for SERPINA7 Gene

Regulatory Elements for SERPINA7 Gene

Enhancers for SERPINA7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERPINA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINA7 Gene

106,032,442 bp from pter
106,038,738 bp from pter
6,297 bases
Minus strand

Genomic View for SERPINA7 Gene

Genes around SERPINA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA7 Gene

Proteins for SERPINA7 Gene

  • Protein details for SERPINA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyroxine-binding globulin
    Protein Accession:
    Secondary Accessions:
    • D3DUX1

    Protein attributes for SERPINA7 Gene

    415 amino acids
    Molecular mass:
    46325 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SERPINA7 Gene

neXtProt entry for SERPINA7 Gene

Proteomics data for SERPINA7 Gene at MOPED

Post-translational modifications for SERPINA7 Gene

  • Glycosylation at Asn 36, Asn 99, Ile 116, Asn 165, and Asn 253
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SERPINA7 (Serpin A7/TBG)

No data available for DME Specific Peptides for SERPINA7 Gene

Domains & Families for SERPINA7 Gene

Gene Families for SERPINA7 Gene

Protein Domains for SERPINA7 Gene


Suggested Antigen Peptide Sequences for SERPINA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serpin family.
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA7: view

Function for SERPINA7 Gene

Molecular function for SERPINA7 Gene

UniProtKB/Swiss-Prot Function:
Major thyroid hormone transport protein in serum.
genes like me logo Genes that share phenotypes with SERPINA7: view

Human Phenotype Ontology for SERPINA7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA7 Gene

Localization for SERPINA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA7 Gene


Subcellular locations from

Jensen Localization Image for SERPINA7 Gene COMPARTMENTS Subcellular localization image for SERPINA7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
genes like me logo Genes that share ontologies with SERPINA7: view

Pathways & Interactions for SERPINA7 Gene

SuperPathways for SERPINA7 Gene

No Data Available

Interacting Proteins for SERPINA7 Gene

Gene Ontology (GO) - Biological Process for SERPINA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 3094014
genes like me logo Genes that share ontologies with SERPINA7: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA7 Gene

Drugs & Compounds for SERPINA7 Gene

(51) Drugs for SERPINA7 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levothyroxine Approved Pharma Carrier 0
Liothyronine Approved Pharma Carrier 0
Liotrix Approved Pharma Carrier 0
NRP409 Investigational Pharma Carrier 0

(16) Additional Compounds for SERPINA7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINA7: view

Transcripts for SERPINA7 Gene


Unigene Clusters for SERPINA7 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -

Relevant External Links for SERPINA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERPINA7 Gene

mRNA expression in normal human tissues for SERPINA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA7 Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for SERPINA7 Gene

This gene is overexpressed in Serum (19.0), Synovial fluid (14.7), Plasma (11.1), and Vitreous humor (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINA7 Gene

SOURCE GeneReport for Unigene cluster for SERPINA7 Gene Hs.76838

mRNA Expression by UniProt/SwissProt for SERPINA7 Gene

Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with SERPINA7: view

Protein tissue co-expression partners for SERPINA7 Gene

- Elite partner

Primer Products

Orthologs for SERPINA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SERPINA7 35
  • 88.78 (n)
  • 84.03 (a)
  • 83 (a)
(Canis familiaris)
Mammalia SERPINA7 35
  • 87.79 (n)
  • 83.59 (a)
TBG 36
  • 82 (a)
(Mus musculus)
Mammalia Serpina7 35
  • 81.8 (n)
  • 76.57 (a)
Serpina7 16
Serpina7 36
  • 74 (a)
(Pan troglodytes)
Mammalia SERPINA7 35
  • 99.76 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Serpina7 35
  • 81.64 (n)
  • 77.05 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11271 35
Species with no ortholog for SERPINA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA7 Gene

Gene Tree for SERPINA7 (if available)
Gene Tree for SERPINA7 (if available)

Paralogs for SERPINA7 Gene Pseudogenes for SERPINA7 Gene

genes like me logo Genes that share paralogs with SERPINA7: view

Variants for SERPINA7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA7 Gene

Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid (PubMed:2495303). TBG-S (s for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile (PubMed:2115061).

Sequence variations from dbSNP and Humsavar for SERPINA7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_007102 Thyroxine-binding globulin deficiency (TBG deficiency)
rs28933689 Thyroxine-binding globulin deficiency (TBG deficiency) 106,036,712(-) TCTGA(A/T)CTGTT reference, missense
rs28933688 Thyroxine-binding globulin deficiency (TBG deficiency) 106,036,662(-) GAAAT(C/G)CCCTC reference, missense
rs1050086 - 106,036,488(-) TTCAA(A/G)ACCTC reference, missense
rs2234036 - 106,035,377(-) AGTGG(A/G)CAAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINA7 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
nsv521259 CNV Gain 19592680
nsv7022 CNV Insertion 18451855
nsv528467 CNV Gain 19592680

Variation tolerance for SERPINA7 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINA7 Gene

Human Gene Mutation Database (HGMD)

Disorders for SERPINA7 Gene

MalaCards: The human disease database

(25) MalaCards diseases for SERPINA7 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thyroxine-binding globulin deficiency
  • thyroxine-binding globulin
congenital isolated thyroxine-binding globulin deficiency
  • congenital isolated tbg deficiency
euthyroid sick syndrome
  • sick-euthyroid syndrome
  • overactive thyroid
- elite association - COSMIC cancer census association via MalaCards


  • Thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]: Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. {ECO:0000269 PubMed:1294376, ECO:0000269 PubMed:1515456, ECO:0000269 PubMed:1901689, ECO:0000269 PubMed:1906047, ECO:0000269 PubMed:2155256, ECO:0000269 PubMed:2501669}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SERPINA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SERPINA7: view

No data available for Genatlas for SERPINA7 Gene

Publications for SERPINA7 Gene

  1. Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect. (PMID: 2155256) Mori Y. … Refetoff S. (J. Clin. Endocrinol. Metab. 1990) 3 4 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Explanation for the high heat stability of thyroxine binding globulin-Chicago. (PMID: 20429632) Duhan U. … Patston P. (Endocr Regul 2010) 3 23
  4. A novel variant in Serpina7 gene in a family with thyroxine-binding globulin deficiency. (PMID: 19415532) Domingues R. … Bugalho M.J. (Endocrine 2009) 3 23
  5. A novel mutation (del 1711 G) in the TBG gene as a cause of complete TBG deficiency. (PMID: 17887925) Lacka K. … Lacki J.K. (Thyroid 2007) 3 23

Products for SERPINA7 Gene

Sources for SERPINA7 Gene