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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINA5 Gene

protein-coding   GIFtS: 66
GCID: GC14P095047

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
(Previous symbols: PLANH3, PCI)
 Explore 22 diseases affiliated with
SERPINA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERPINA5    

Aliases
for SERPINA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin),
Member 51 2
     Serpin A52 3
PCI1 2 3 5     PAI-32 3
PAI31 2 3     PCI-B2
PLANH31 2 3     Plasma Serine Protease Inhibitor2
PROCI1 2 3     Plasminogen Activator Inhibitor III2
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 51 2
     Plasminogen Activator Inhibitor-32
Acrosomal Serine Protease Inhibitor2 3     Plasminogen Activator Inhibitor 33
Protein C Inhibitor2 3     SERPNA55

External Ids:    HGNC: 87231   Entrez Gene: 51042   Ensembl: ENSG000001884887   OMIM: 6018415   UniProtKB: P051543   

Export aliases for SERPINA5 gene to outside databases

Previous GC identifers: GC14P092555 GC14P088864 GC14P093018 GC14P093021 GC14P093037 GC14P094117 GC14P075228


Summaries
for SERPINA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SERPINA5:
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine
proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is
a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and
kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. (provided by RefSeq, Aug
2012)

UniProtKB/Swiss-Prot: IPSP_HUMAN, P05154
Function: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine
proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and
extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and
proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of
activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood
coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue-
and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the
reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being
degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific
antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated
protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of
transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type
plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as
MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May
also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to
retinoic acid

Gene Wiki entry for SERPINA5 (Protein C inhibitor)


Genomic Views
for SERPINA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINA5 gene promoter:
         NF-1   NF-1/L   HSF1 (long)   LUN-1   YY1   Max   HSF2   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERPINA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.1

SERPINA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P095047:  view genomic region     (about GC identifiers)

Start:
 95,027,779 bp from pter      End:
 95,059,457 bp from pter
Size:
 31,679 bases      Orientation:
 plus strand

Proteins
for SERPINA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IPSP_HUMAN, P05154 (See protein sequence)
Recommended Name: Plasma serine protease inhibitor precursor  
Size: 406 amino acids; 45675 Da
Subunit: Forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated
protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor
XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen
activator/PLAT and urinary plasminogen activator/PLAU. Forms membrane-anchored serine proteases inhibiting
heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2
Subcellular location: Secreted, extracellular space. Note=Localized on the plasma membrane overlying the acrosomal head
of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted
spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the
surface-connected cannalicular system in activated platelets
6 PDB 3D structures from and Proteopedia for SERPINA5:
1LQ8 (3D)        1PAI (3D)        2HI9 (3D)        2OL2 (3D)        2PAI (3D)        3DY0 (3D)    
Secondary accessions: Q07616 Q9UG30

Explore the universe of human proteins at neXtProt for SERPINA5: NX_P05154

Post-translational modifications:

  • N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes),
    • tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of
    thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid
    residues1
  • Proteolytically cleaved. Inhibition of proteases is accompanied by formation of a stable enzyme-inhibitor complex and
    • by degradation of the serpin to lower molecular weight derivatives. Proteolytically cleaved at the N-terminus;
    inhibits slightly the heparin- and thrombomodulin-enhanced rates of thrombin inhibition1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05154

    • SERPINA5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000615.3  
    ENSEMBL proteins: 
     ENSP00000450484   ENSP00000450837   ENSP00000452469   ENSP00000451126   ENSP00000450745  
     ENSP00000451215   ENSP00000451036   ENSP00000451697   ENSP00000451650   ENSP00000451610  
     ENSP00000450485   ENSP00000451487   ENSP00000333203  

    Human Recombinant Protein Products: 
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    Novus Biologicals SERPINA5 Proteins
    Novus Biologicals SERPINA5 Lysates
    Sino Biological Recombinant Protein for SERPINA5
    ProSpec Recombinant Protein for SERPINA5
    Uscn Proteins for SERPINA5

    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IDA9510955
    GO:0005576extracellular region TAS11120760
    GO:0005615extracellular space IDA10340997
    GO:0009897external side of plasma membrane IDA9556620
    GO:0016020membrane IDA7521127


    SERPINA5 for ontologies           About GeneDecksing



    SERPINA5 Antibody Products: 
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    Protein Domains /
    Families
    for SERPINA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERPINA5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P05154

    ProtoNet protein and cluster: P05154

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: IPSP_HUMAN, P05154
    Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target
    protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between
    the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive
    serpin-protease complex is highly stable
    Similarity: Belongs to the serpin family


    Function
    for SERPINA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IPSP_HUMAN, P05154
    Function: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine
    proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and
    extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and
    proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of
    activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood
    coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue-
    and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the
    reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being
    degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific
    antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated
    protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of
    transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type
    plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as
    MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May
    also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to
    retinoic acid
    Enzyme regulation: Its inhibitory activity is greatly enhanced in the presence of glycosaminoglycans, heparin,
    thrombomodulin and phospholipids vesicles

    miRNA
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    hsa-miR-198 hsa-miR-525-5p hsa-miR-634 hsa-miR-518a-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-450b-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SERPINA5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SERPINA5
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA11722589
    GO:0002020protease binding IPI2844223
    GO:0004867serine-type endopeptidase inhibitor activity IDA15853774
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding TAS8796266


    SERPINA5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SERPINA5:
     Increased homologous recombina 

    Animal Models:
         Mouse knock-out Serpina5tm1Gei for SERPINA5
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpina5):
     endocrine/exocrine gland  reproductive system 

    SERPINA5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SERPINA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Complement and coagulation cascades
    		Complement and coagulation cascades1.00
    		Complement and Coagulation Cascades0.72
    2Development_CNTF receptor signaling
    		Cell adhesion PLAU signaling0.35
    		Cell adhesion_PLAU signaling0.35
    3Formation of Fibrin Clot (Clotting Cascade)
    		Blood Coagulation Signaling Pathways0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SERPINA5
        Cell adhesion PLAU signaling

    1 R&D Systems Pathway for SERPINA5
        Blood Coagulation Signaling Pathways


    1 GeneGo (Thomson Reuters) Pathway for SERPINA5
        Cell adhesion PLAU signaling

    1 BioSystems Pathway for SERPINA5 
        Complement and Coagulation Cascades


    1         Kegg Pathway  (Kegg details for SERPINA5):
        Complement and coagulation cascades


    SERPINA5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for SERPINA5 (P051542, 3 ENSP000003332034) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N12, 3MINT-63402 I2D: score=5 
    ACRP103233, ENSP000002161394I2D: score=2 STRING: ENSP00000216139
    KLKB1P039523, ENSP000002646904I2D: score=2 STRING: ENSP00000264690
    PLATP007503, ENSP000002208094I2D: score=2 STRING: ENSP00000220809
    PROCP040703, ENSP000002340714I2D: score=2 STRING: ENSP00000234071
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--
    GO:0007283spermatogenesis ISS--
    GO:0007342fusion of sperm to egg plasma membrane NAS9510955
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--


    SERPINA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERPINA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINA5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SERPINA5

    2 DrugBank Compounds for SERPINA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--10456457 12671072 8391599 7769227 9620917
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--14645112 17434507 17253188

    4 Novoseek chemical compound relationships for SERPINA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 50.9 10 15752693 (1), 18983517 (1), 12413592 (1), 12176977 (1) (see all 8)
    heparin 48.6 2 12413592 (1), 12818196 (1)
    fibrinogen 36.3 2 8128433 (1), 7571997 (1)
    warfarin 28.5 1 10499903 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINA5 / IPSP 

    Transcripts
    for SERPINA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERPINA5 gene: 
    NM_000624.5  

    Unigene Cluster for SERPINA5:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
    Hs.159628  [show with all ESTs]
    Unigene Representative Sequence: NM_000624
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554220 ENST00000553780 ENST00000556730(uc010ave.2) ENST00000554760
    ENST00000554866 ENST00000556775(uc001ydn.1) ENST00000553511 ENST00000554506
    ENST00000554633 ENST00000555681 ENST00000554276 ENST00000557598 ENST00000556064
    ENST00000329597(uc001ydm.2)

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK096131.1 AK293192.1 AK298279.1 AL080185.1 BC008915.2 J02639.1 S58545.1 U35464.1 

    24/25 DOTS entries (see all 25):

    DT.95255240  DT.100831497  DT.85104682  DT.91926531  DT.120779232  DT.92400801  DT.87016075  DT.91944271 
    DT.120779169  DT.92430151  DT.92430155  DT.120779330  DT.120779240  DT.95231261  DT.95255243  DT.120779130 
    DT.120779188  DT.85104683  DT.92068908  DT.100678995  DT.120779133  DT.120779181  DT.120779184  DT.95255238 

    24/1378 AceView cDNA sequences (see all 1378):

    BI825430 CR617878 BU676732 CR592388 CB164422 CB154214 BX450542 BQ676970 
    BF338395 BI825453 CR601472 BU736863 N59384 CB163692 CR622184 CR614066 
    AA370764 AA341620 CB850742 BQ181477 CR620629 AA337197 BM821233 BX448978 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA5 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a ·
    SP1:                                -     -     -     -     -                       -     -     -                                                               
    SP2:                                      -     -     -     -                                                                                                   
    SP3:                          -     -     -     -     -     -                 -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 11b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SERPINA5

    Expression
    for SERPINA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAAAATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SERPINA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)

    See SERPINA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINA5

    SOURCE GeneReport for Unigene cluster: Hs.159628

    UniProtKB/Swiss-Prot: IPSP_HUMAN, P05154
    Tissue specificity: Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular
    epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin.
    Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney
    tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration
    in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids.
    Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly
    expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig
    cells, epididymal glands, seminal vesicles and prostate

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    Orthologs
    for SERPINA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINA5 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1742606
    zgc:1742596
    (see all 8)    		 zgc:174259
    (see all 8)    		 33(a)
    32(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 5(30450534-30456663)
    5(30486928-30489465)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Spn36
    Spn42De6
    (see all 26)    		 Serpin 42De
    (see all 26)    		 28(a)
    27(a)
    (see all 26)    		 possible ortholog
    possible ortholog
    (see all 26)    		 2L(20836621-20838179)
    2R(2773123-2775767)
    worm
    (Caenorhabditis elegans)    		 Secernentea srp-13 serine protease inhibitor 29(a)   V(753188-754813)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G640106
    ATSRP36
    (see all 10)    		 serpin-Z1
    (see all 10)    		 25(a)
    24(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 1(23750884-23751441)
    1(23752873-23754348)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 serpin domain containing protein, putative
    (see all 16)    		 24(a)
    23(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 3(23053071-23066803)
    11(7415381-7416754)


    ENSEMBL Gene Tree for SERPINA5 (if available)
    TreeFam Gene Tree for SERPINA5 (if available) 

    Paralogs
    for SERPINA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINA5 gene
    SERPING12  SERPINA12  SERPINH12  SERPINA102  SERPINA112  SERPINA72  SERPINA122  SERPINA92  
    SERPINF12  SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
    18/36 SIMAP similar genes for SERPINA5 using alignment to 10 protein entries:     IPSP_HUMAN (see all proteins) (see all similar genes):
    AAT    AT3    DKFZp686D06190    SERPINI1    PLANH2    SERPINA9
    SERPINA3    SERPINB11    SERPINA4    SERPINA7    SERPINA11    SERPINB6
    SERPINA12    SERPINI2    SERPINA13P    SERPINA6    DKFZp686O07189    SERPINB3

    SERPINA5 for paralogs           About GeneDecksing



    Genomic Variants
    for SERPINA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/391 NCBI SNPs in SERPINA5 are shown (see all 391)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs764150951,2
    		F,--75226424(+) GGACAC/TGGATA 1 -- us2k12Minor allele frequency- T:0.01WA NA 238
    rs765092581,2
    		C,F,--75226502(+) TAGGGA/GTCTCT 1 -- us2k12Minor allele frequency- G:0.05WA NA 238
    rs740758501,2
    		C,F,--75227362(+) ATCACG/TGCCAT 1 -- us2k13Minor allele frequency- T:0.10WA CSA 122
    rs14759371,2
    		C,F,H,--75227384(+) CATGTC/TCCCCA 1 -- us2k19Minor allele frequency- T:0.09NS EA NA WA 642
    rs65754471,2
    		C,A,H,--75227439(+) TGCACC/TGGTGT 1 -- us2k14Minor allele frequency- T:0.02NS EA WA 400
    rs118474521,2
    		C,F,H,--75227982(+) AAAATG/TATGGC 1 -- us2k113Minor allele frequency- T:0.10NS EA NA WA CSA 1394
    rs21440761,2
    		C,F,--75228113(+) CTGTCC/TCGGGG 1 -- us2k16Minor allele frequency- T:0.20WA NA EA 364
    rs619782951,2
    		--75228684(+) GTTCAG/AAAGGT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs619782961,2
    		F,--75228744(+) TGTCGG/CCTGGA 1 -- int13Minor allele frequency- C:0.05NA CSA WA 122
    rs1124879571,2
    		--75229116(+) CGGACA/GTGTTC 1 -- int12Minor allele frequency- G:0.33CSA 3

    HapMap Linkage Disequilibrium report for SERPINA5 (95027779 - 95059457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SERPINA5: --

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    Disorders / Diseases
    for SERPINA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERPINA5 for disorders           About GeneDecksing

    OMIM gene information: 601841    OMIM disorders: --

    20/22 diseases for SERPINA5 (see all 22):    About MalaCards
    thrombosis    disseminated intravascular coagulation    factor viii deficiency    abdominal aortic aneurysm
    aortic aneurysm    wegener's granulomatosis    venous thrombosis    pulmonary embolism
    male infertility    sickle cell disease    small cell carcinoma    myocardial infarction
    renal cell carcinoma    uremia    infertility    hepatitis b
    prostate cancer    breast cancer    carcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SERPINA5:
    Disseminated intravascular coagulation

    2 Novoseek disease relationships for SERPINA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    venous thrombosis 21.7 2 8418545 (1), 12139754 (1)
    tumors 0 4 18983517 (2), 2153429 (1)

    Genetic Association Database (GAD): SERPINA5
    Human Genome Epidemiology (HuGE) Navigator: SERPINA5 (6 documents)

    Export disorders for SERPINA5 gene to outside databases

    Publications
    for SERPINA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINA5 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with SERPINA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14. (PubMed id 1714450)1, 2, 3, 9 Meijers J.C.M. and Chung D.W. (1991)
    2. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. (PubMed id 1725227)1, 2, 9 Espana F....Cabo A. (1991)
    3. Further insight into the roles of the glycans attache d to human blood protein C inhibitor. (PubMed id 21056543)1, 2 Sun W....Schedin-Weiss S. (2010)
    4. The heparin binding site of protein C inhibitor is protease-dependent. (PubMed id 18974053)1, 2 Li W. and Huntington J.A. (2008)
    5. Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. (PubMed id 18362344)1, 2 Li W.... Huntington J.A. (2008)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. (PubMed id 15853774)1, 2 Szabo R....Bugge T.H. (2005)
    8. Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. (PubMed id 14696115)1, 2 Wakita T....Suzuki K. (2004)
    9. Absence of mutations in the PCI gene in subfertile men. (PubMed id 15377716)1, 4 Gianotten J....Meijers J.C. (2004)
    10. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)

    External Searches for SERPINA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SERPINA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5104 HGNC: 8723 AceView: SERPINA5andSERPINA3 Ensembl:ENSG00000188488 euGenes: HUgn5104
    ECgene: SERPINA5 Kegg: 5104 H-InvDB: SERPINA5

    Other Databases showing SERPINA5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERPINA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINA5 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/serpina5/

    Intellectual Property
    for SERPINA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERPINA5 gene:
    Search GeneIP for patents involving SERPINA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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