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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINA4 Gene

protein-coding   GIFtS: 55
GCID: GC14P095027

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
(Previous symbol: PI4)
 Explore 16 diseases affiliated with
SERPINA4 via our new
 Human Malady Compendium 
Biological research products
for SERPINA4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin),
Member 41 2
     Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 41 2
KST1 2 3 5     Kallikrein Inhibitor2 3
PI41 2 3 5     Peptidase Inhibitor 42 3
KAL1 2     Serpin A42 3
KLST1 2     PI-42 3
Kallistatin1     Protease Inhibitor 4 (Kallistatin)2

External Ids:    HGNC: 89481   Entrez Gene: 52672   Ensembl: ENSG000001006657   OMIM: 1479355   UniProtKB: P296223   

Export aliases for SERPINA4 gene to outside databases

Previous GC identifers: GC14P092535 GC14P088844 GC14P093017 GC14P094097 GC14P075208


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KAIN_HUMAN, P29622
Function: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by
formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a
small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein

Gene Wiki entry for SERPINA4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINA4 gene promoter:
         NF-1   NF-1/L   HSF1 (long)   CREB   MZF-1   HEN1   HSF2   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

SERPINA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P095027:  view genomic region     (about GC identifiers)

Start:
95,027,428 bp from pter      End:
95,036,250 bp from pter
Size:
8,823 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KAIN_HUMAN, P29622 (See protein sequence)
Recommended Name: Kallistatin precursor  
Size: 427 amino acids; 48542 Da
Subunit: Monomer and some homodimers
Subcellular location: Secreted
Miscellaneous: Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory
effect on tissue kallikrein's activity
Sequence caution: Sequence=CAD66567.1; Type=Erroneous initiation;
Secondary accessions: Q53XB5 Q86TR9 Q96BZ5

Explore the universe of human proteins at neXtProt for SERPINA4: NX_P29622

Post-translational modifications:

  • The N-terminus is blocked1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29622

  • SERPINA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006206.2  
    ENSEMBL proteins: 
     ENSP00000450838   ENSP00000451172   ENSP00000298841  

    Human Recombinant Protein Products: 
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    Novus Biologicals SERPINA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERPINA4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--


    SERPINA4 for ontologies           About GeneDecksing



    SERPINA4 Antibody Products: 
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    ThermoFisher Antibodies for SERPINA4

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    Uscn ELISAs and CLIAs for SERPINA4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SERPINA4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023795 Protease_inhib_I4_serpin_CS
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry P29622

    ProtoNet protein and cluster: P29622

    1 Blocks protein family: IPB000215 Serpin

    UniProtKB/Swiss-Prot: KAIN_HUMAN, P29622
    Similarity: Belongs to the serpin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KAIN_HUMAN, P29622
    Function: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by
    formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a
    small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SERPINA4:
    hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidSERPINA4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--


    SERPINA4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SERPINA4:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINA4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/13 Interacting proteins for SERPINA4 (P296222, 3 ENSP000002988414) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASA1P209362, 3, ENSP000002743764MINT-8268229 I2D: score=2 STRING: ENSP00000274376
    GADD45GO952572, 3MINT-8256272 I2D: score=2 
    ILKQ134182, 3MINT-8258632 I2D: score=2 
    MAP4K2Q128512, 3MINT-8260460 I2D: score=2 
    MAPK6Q166592, 3MINT-8261934 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--


    SERPINA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINA4
    9 Novoseek chemical compound relationships for SERPINA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-(2,4-dinitrophenyl)ethylenediamine 86.5 1 12578561 (1)
    kininogen 76.9 6 11557611 (2), 11204593 (1), 1334488 (1), 9072045 (1) (see all 5)
    anthranilate 64.2 2 10191281 (1), 12578561 (1)
    serine 62.6 20 8227002 (2), 8648266 (1), 8796269 (1), 8950506 (1) (see all 17)
    aprotinin 34.4 2 10547191 (1)
    heparin 31.9 16 11016932 (7), 10991942 (3), 12000310 (1), 20432946 (1) (see all 5)
    matrigel 27.9 3 12384424 (1), 12734113 (1)
    nitric oxide 1.54 13 17081080 (2), 18762777 (2), 19858207 (2), 9202051 (1)
    vegf 1.52 8 12734113 (5), 12384424 (2)

    Search CenterWatch for drugs/clinical trials and news about SERPINA4 / KAIN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINA4 gene: 
    NM_006215.2  

    Unigene Cluster for SERPINA4:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
    Hs.719893  [show with all ESTs]
    Unigene Representative Sequence: AK309586
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557004 ENST00000555095(uc010avd.3 uc001ydk.3 uc001ydl.3)
    ENST00000298841

    miRNA
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    hsa-miR-1976
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINA4

    Additional cDNA sequence: 

    AK309586.1 AK313196.1 BC014992.1 BX248009.1 BX248760.1 L19684.1 

    4 DOTS entries:

    DT.446447  DT.101978469  DT.120779247  DT.100668663 

    24/67 AceView cDNA sequences (see all 67):

    N58558 BQ653446 BX248009 CB163180 BU581263 CR605698 AW291599 BC014992 
    CR622620 AA342125 NM_006215 BX248760 BX405823 BX444089 BU581587 BQ654193 
    C21116 CB164002 BX450550 L19684 BX427994 BE870736 BX405822 BX444171 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
    SP1:        -     -                                       
    SP2:                                                      
    SP3:              -                                       


    ECgene alternative splicing isoforms for SERPINA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGATACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SERPINA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINA4

    SOURCE GeneReport for Unigene cluster: Hs.719893

    UniProtKB/Swiss-Prot: KAIN_HUMAN, P29622
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERPINA4 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1742606
    serpina1l6
    (see all 8)
    zgc:174260
    serine (or cysteine) proteinase inhibitor, clade A...
    (see all 8)
    35(a)
    35(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    5(30450534-30456663)
    20(10726062-10728283)
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn66
    Spn42De6
    (see all 26)
    Serpin 42De
    (see all 26)
    27(a)
    26(a)
    (see all 26)
    possible ortholog
    possible ortholog
    (see all 26)
    2R(14013810-14015715)
    2R(2773123-2775767)
    worm
    (Caenorhabditis elegans)
    Secernentea srp-26
    srp-16
    (see all 6)
    SeRPin family member (srp-1)
    (see all 6)
    26(a)
    26(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    V(762735-764658)
    V(753335-755049)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G640106
    AT1G477106
    (see all 10)
    serpin-ZX
    (see all 10)
    24(a)
    23(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    1(23750884-23751441)
    1(17558209-17560269)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 16)
    serpin domain containing protein, putative
    (see all 16)
    24(a)
    22(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    3(23053071-23066803)
    11(7415381-7416754)


    ENSEMBL Gene Tree for SERPINA4 (if available)
    TreeFam Gene Tree for SERPINA4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINA4 gene
    SERPING12  SERPINA12  SERPINH12  SERPINA102  SERPINA112  SERPINA72  SERPINA122  SERPINA92  
    SERPINA52  SERPINF12  SERPIND12  SERPINA32  SERPINA62  SERPINF22  
    18/26 SIMAP similar genes for SERPINA4 using alignment to 1 protein entry:     KAIN_HUMAN(see all similar genes):
    SERPINA9    SERPINA11    SERPINA6    SERPINA1    SERPINA3    SERPINA5
    SERPINA7    SERPINA12    SERPINA2P    SERPINA13P    SERPINI2    SERPINB1
    SERPINB6    SERPINB9    SERPINC1    SERPINB13    SERPINB3    SERPINB8

    SERPINA4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERPINA4
    PGOHUM00000250153


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    4 NCBI SNPs in SERPINA4 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342763041,2
    C--95027377(+) AGGAA-/GGCGGCGC 1 -- us2k10--------
    rs1419381951,2
    C,--95027377(+) AGGAA-/GGCGGCGC 1 -- us2k10--------
    rs30658701,2
    C--95027378(+) AGGCG-/GCGCTGGA 1 -- us2k11Minor allele frequency- GCG:0.00NA 2
    rs593800011,2
    ----95027378(+) AGGCG-/GCGCTGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERPINA4 (95027428 - 95036250 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SERPINA4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINA4
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SERPINA4 for disorders           About GeneDecksing

    OMIM gene information: 147935    OMIM disorders: --

    16 diseases for SERPINA4:    About MalaCards
    inflammatory bowel disease    protein c deficiency    ulcerative colitis    diabetic retinopathy
    myocardial infarction    angioedema    urticaria    acute pancreatitis
    ischemia    hepatocellular carcinoma    osteoarthritis    arthritis
    pancreatitis    hypertension    hypoxia    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SERPINA4:
    Urticaria

    7 Novoseek disease relationships for SERPINA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis ulcerative 32.8 4 15949977 (2), 12810351 (1), 12757180 (1)
    inflammation 24.3 7 17081080 (2), 15949977 (2), 19858207 (1), 9349723 (1)
    inflammatory bowel diseases 22 4 15949977 (2), 12810351 (1), 12757180 (1)
    arthritis 0.0923 2 17081080 (1), 15818689 (1)
    ischemia 0 2 12384424 (1), 11258665 (1)
    necrosis 0 4 17081080 (1), 19858207 (1)
    tumors 0 9 12384424 (2), 17081080 (1), 12734113 (1), 18338836 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: SERPINA4 (3 documents)

    Export disorders for SERPINA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINA4 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with SERPINA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. (PubMed id 8227002)1, 2, 3, 9 Chai K.X.... Chao L. (1993)
    2. Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. (PubMed id 1334488)1, 2, 9 Zhou G.X.... Chao J. (1992)
    3. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). (PubMed id 7835886)1, 2, 9 Chai K.X.... Chao L. (1994)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    7. Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy. (PubMed id 8950506)1, 9 Ma J.X....Chao J. (1996)
    8. Novel roles of kallistatin, a specific tissue kallikrein inhibitor, in vascular remodeling. (PubMed id 11258665)1, 9 Chao J....Chao L. (2001)
    9. Structural elements of kallistatin required for inhibition of angiogenesis. (PubMed id 12734113)1, 9 Miao R.Q....Chao J. (2003)
    10. Kallistatin is a new inhibitor of angiogenesis and tumor growth. (PubMed id 12384424)1, 9 Miao R.Q....Chao J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5267 HGNC: 8948 AceView: SERPINA4 Ensembl:ENSG00000100665 euGenes: HUgn5267
    ECgene: SERPINA4 H-InvDB: SERPINA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINA4 gene:
    Search GeneIP for patents involving SERPINA4

    GeneCards and IP:
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