Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINA4 Gene

Aliases for SERPINA4 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 2 3
  • Peptidase Inhibitor 4 3 4
  • Kallikrein Inhibitor 3 4
  • Serpin A4 3 4
  • PI-4 3 4
  • PI4 3 4
  • KST 3 4
  • Protease Inhibitor 4 (Kallistatin) 3
  • Kallistatin 3
  • KLST 3
  • KAL 3

External Ids for SERPINA4 Gene

Previous HGNC Symbols for SERPINA4 Gene

  • PI4

Previous GeneCards Identifiers for SERPINA4 Gene

  • GC14P092535
  • GC14P088844
  • GC14P093017
  • GC14P094097
  • GC14P095027
  • GC14P075208

Summaries for SERPINA4 Gene

GeneCards Summary for SERPINA4 Gene

SERPINA4 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA4 Gene

  • Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Gene Wiki entry for SERPINA4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA4 Gene

Genomics for SERPINA4 Gene

Regulatory Elements for SERPINA4 Gene

Genomic Location for SERPINA4 Gene

Chromosome:
14
Start:
94,561,091 bp from pter
End:
94,569,913 bp from pter
Size:
8,823 bases
Orientation:
Plus strand

Genomic View for SERPINA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA4 Gene

Proteins for SERPINA4 Gene

  • Protein details for SERPINA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29622-KAIN_HUMAN
    Recommended name:
    Kallistatin
    Protein Accession:
    P29622
    Secondary Accessions:
    • Q53XB5
    • Q86TR9
    • Q96BZ5

    Protein attributes for SERPINA4 Gene

    Size:
    427 amino acids
    Molecular mass:
    48542 Da
    Quaternary structure:
    • Monomer and some homodimers
    Miscellaneous:
    • Heparin blocks kallistatins complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikreins activity
    SequenceCaution:
    • Sequence=CAD66567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA4 Gene

Proteomics data for SERPINA4 Gene at MOPED

Post-translational modifications for SERPINA4 Gene

Other Protein References for SERPINA4 Gene

Antibody Products

  • R&D Systems Antibodies for SERPINA4 (Serpin A4/Kallistatin)

No data available for DME Specific Peptides for SERPINA4 Gene

Domains & Families for SERPINA4 Gene

Gene Families for SERPINA4 Gene

Protein Domains for SERPINA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29622

UniProtKB/Swiss-Prot:

KAIN_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA4: view

Function for SERPINA4 Gene

Molecular function for SERPINA4 Gene

UniProtKB/Swiss-Prot Function:
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Gene Ontology (GO) - Molecular Function for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA4: view

Phenotypes for SERPINA4 Gene

genes like me logo Genes that share phenotypes with SERPINA4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINA4 Gene

Localization for SERPINA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA4 Gene COMPARTMENTS Subcellular localization image for SERPINA4 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
nucleus 2
plasma membrane 2
vacuole 2
chloroplast 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20551380
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SERPINA4: view

Pathways & Interactions for SERPINA4 Gene

SuperPathways for SERPINA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SERPINA4: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA4 Gene

Drugs & Compounds for SERPINA4 Gene

(4) Drugs for SERPINA4 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540
serine Nutra 420

(5) Additional Compounds for SERPINA4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
anthranilate
Kininogen
Matrigel
N-(2,4-Dinitrophenyl)ethylenediamine
VEGF
genes like me logo Genes that share compounds with SERPINA4: view

Transcripts for SERPINA4 Gene

Unigene Clusters for SERPINA4 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
SP1: - -
SP2:
SP3: -

Relevant External Links for SERPINA4 Gene

GeneLoc Exon Structure for
SERPINA4
ECgene alternative splicing isoforms for
SERPINA4

Expression for SERPINA4 Gene

mRNA expression in normal human tissues for SERPINA4 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA4 Gene

This gene is overexpressed in Liver (x31.4) and Pancreas (x18.1).

Protein differential expression in normal tissues from HIPED for SERPINA4 Gene

This gene is overexpressed in Serum (23.2), Synovial fluid (15.1), Plasma (9.9), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINA4 Gene



SOURCE GeneReport for Unigene cluster for SERPINA4 Gene Hs.719893

mRNA Expression by UniProt/SwissProt for SERPINA4 Gene

P29622-KAIN_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expression patterns with SERPINA4: view

Protein tissue co-expression partners for SERPINA4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SERPINA4 Gene

Orthologs for SERPINA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SERPINA4 35
  • 79.07 (n)
  • 71.96 (a)
SERPINA4 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINA4 35
  • 99.43 (n)
  • 99.35 (a)
SERPINA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina4 35
  • 67.99 (n)
  • 57.07 (a)
mouse
(Mus musculus)
Mammalia Serpina4-ps1 16
cow
(Bos Taurus)
Mammalia SERPINA4 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA4 36
  • 52 (a)
OneToOne
Species with no ortholog for SERPINA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA4 Gene

ENSEMBL:
Gene Tree for SERPINA4 (if available)
TreeFam:
Gene Tree for SERPINA4 (if available)

Paralogs for SERPINA4 Gene

Pseudogenes.org Pseudogenes for SERPINA4 Gene

genes like me logo Genes that share paralogs with SERPINA4: view

Variants for SERPINA4 Gene

Sequence variations from dbSNP and Humsavar for SERPINA4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs5508 -- 94,563,515(+) CTGCT(G/T)GTTGG reference, synonymous-codon
rs5509 -- 94,563,893(+) GAAAC(A/G)CGCGT reference, synonymous-codon
rs5510 -- 94,567,019(-) ACATA(A/G)AAGTC reference, synonymous-codon
rs5511 -- 94,567,258(+) GTGCT(A/T)TGGGG intron-variant
rs5512 -- 94,568,116(+) ACTCA(A/G)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA4 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832865 CNV Gain 17160897

Variation tolerance for SERPINA4 Gene

Residual Variation Intolerance Score: 46.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINA4 Gene

HapMap Linkage Disequilibrium report
SERPINA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA4 Gene

Disorders for SERPINA4 Gene

Relevant External Links for SERPINA4

Genetic Association Database (GAD)
SERPINA4
Human Genome Epidemiology (HuGE) Navigator
SERPINA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINA4
genes like me logo Genes that share disorders with SERPINA4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINA4 Gene

Publications for SERPINA4 Gene

  1. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. (PMID: 8227002) Chai K.X. … Chao L. (J. Biol. Chem. 1993) 2 23 67
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 67
  3. Increased tissue kallikrein levels in type 2 diabetes. (PMID: 20225398) Campbell D.J. … Kelly D.J. (Diabetologia 2010) 23 67
  4. [High level expression of recombinant human kallistatin in Pichia pastoris and its bioactivity]. (PMID: 20432946) Huang X. … Diao Y. (Sheng Wu Gong Cheng Xue Bao 2010) 23 67
  5. Kruppel-like factor 4 is a novel mediator of Kallistatin in inhibiting endothelial inflammation via increased endothelial nitric-oxide synthase expression. (PMID: 19858207) Shen B. … Chao J. (J. Biol. Chem. 2009) 23 67

Products for SERPINA4 Gene

Sources for SERPINA4 Gene

Back to Top

Content