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Aliases for SERPINA4 Gene

Aliases for SERPINA4 Gene

  • Serpin Family A Member 4 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 2 3
  • Sserpin Family A Member 4 2 3
  • Peptidase Inhibitor 4 3 4
  • Kallikrein Inhibitor 3 4
  • Serpin A4 3 4
  • PI-4 3 4
  • PI4 3 4
  • KST 3 4
  • Protease Inhibitor 4 (Kallistatin) 3
  • Testicular Secretory Protein Li 22 3
  • Kallistatin 3
  • KLST 3
  • KAL 3

External Ids for SERPINA4 Gene

Previous HGNC Symbols for SERPINA4 Gene

  • PI4

Previous GeneCards Identifiers for SERPINA4 Gene

  • GC14P092535
  • GC14P088844
  • GC14P093017
  • GC14P094097
  • GC14P095027
  • GC14P075208

Summaries for SERPINA4 Gene

GeneCards Summary for SERPINA4 Gene

SERPINA4 (Serpin Family A Member 4) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA9.

UniProtKB/Swiss-Prot for SERPINA4 Gene

  • Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Gene Wiki entry for SERPINA4 Gene

Additional gene information for SERPINA4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA4 Gene

Genomics for SERPINA4 Gene

GeneHancer (GH) Regulatory Elements for SERPINA4 Gene

Promoters and enhancers for SERPINA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094560 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.4 371 2.2 DRAP1 HNF1A SAP130 POLR2A HNF4A SERPINA5 SERPINA4 SERPINA3 ENSG00000273259
GH14I094597 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +39.1 39113 6.1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 SERPINA10 SERPINA3 SERPINA1 SERPINA5 SCARNA13 SNHG10 DICER1 SERPINA6 SERPINA11 SERPINA4
GH14I094593 Enhancer 1.2 FANTOM5 ENCODE 15 +33.0 32976 1.1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 SERPINA5 SERPINA1 SERPINA6 SERPINA11 SERPINA10 SERPINA3 SERPINA4 ENSG00000273259
GH14I094539 Enhancer 0.7 ENCODE 11.7 -21.0 -20990 1 ELF3 CTCF TFAP4 PKNOX1 KLF11 SAP130 ZNF511 ARID4B EBF1 DMAP1 SERPINA4 SERPINA12
GH14I094536 Enhancer 0.7 ENCODE 10.7 -24.1 -24102 0.2 CTCF PKNOX1 BMI1 ZNF644 ZBTB40 RAD21 HSF1 ATF7 HOMEZ RFX1 SERPINA4 ENSG00000256357 SERPINA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINA4 gene promoter:

Genomic Locations for SERPINA4 Gene

Genomic Locations for SERPINA4 Gene
chr14:94,561,091-94,569,913
(GRCh38/hg38)
Size:
8,823 bases
Orientation:
Plus strand
chr14:95,027,428-95,036,250
(GRCh37/hg19)

Genomic View for SERPINA4 Gene

Genes around SERPINA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA4 Gene

Proteins for SERPINA4 Gene

  • Protein details for SERPINA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29622-KAIN_HUMAN
    Recommended name:
    Kallistatin
    Protein Accession:
    P29622
    Secondary Accessions:
    • Q53XB5
    • Q86TR9
    • Q96BZ5

    Protein attributes for SERPINA4 Gene

    Size:
    427 amino acids
    Molecular mass:
    48542 Da
    Quaternary structure:
    • Monomer and some homodimers.
    Miscellaneous:
    • Heparin blocks kallistatins complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikreins activity.
    SequenceCaution:
    • Sequence=CAD66567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA4 Gene

Post-translational modifications for SERPINA4 Gene

  • The N-terminus is blocked.
  • Glycosylation at posLast=3333, posLast=108108, posLast=157157, and isoforms=238

Other Protein References for SERPINA4 Gene

Antibody Products

  • R&D Systems Antibodies for SERPINA4 (Serpin A4/Kallistatin)

No data available for DME Specific Peptides for SERPINA4 Gene

Domains & Families for SERPINA4 Gene

Gene Families for SERPINA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SERPINA4 Gene

Suggested Antigen Peptide Sequences for SERPINA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29622

UniProtKB/Swiss-Prot:

KAIN_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA4: view

Function for SERPINA4 Gene

Molecular function for SERPINA4 Gene

UniProtKB/Swiss-Prot Function:
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Phenotypes From GWAS Catalog for SERPINA4 Gene

Gene Ontology (GO) - Molecular Function for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA,TAS --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA4: view
genes like me logo Genes that share phenotypes with SERPINA4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERPINA4 Gene

Localization for SERPINA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA4 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
endosome 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS --
GO:0005615 extracellular space IEA,IDA 20551380
GO:0031089 platelet dense granule lumen TAS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with SERPINA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINA4 Gene

Pathways & Interactions for SERPINA4 Gene

genes like me logo Genes that share pathways with SERPINA4: view

Gene Ontology (GO) - Biological Process for SERPINA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINA4: view

No data available for SIGNOR curated interactions for SERPINA4 Gene

Drugs & Compounds for SERPINA4 Gene

(6) Drugs for SERPINA4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Zinc Approved, Investigational Pharma Target 2430

(5) Additional Compounds for SERPINA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINA4: view

Transcripts for SERPINA4 Gene

Unigene Clusters for SERPINA4 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
SP1: - -
SP2:
SP3: -

Relevant External Links for SERPINA4 Gene

GeneLoc Exon Structure for
SERPINA4
ECgene alternative splicing isoforms for
SERPINA4

Expression for SERPINA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINA4 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA4 Gene

This gene is overexpressed in Liver (x31.4) and Pancreas (x18.1).

Protein differential expression in normal tissues from HIPED for SERPINA4 Gene

This gene is overexpressed in Serum (23.2), Synovial fluid (15.1), Plasma (9.9), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINA4 Gene



Protein tissue co-expression partners for SERPINA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERPINA4 Gene:

SERPINA4

SOURCE GeneReport for Unigene cluster for SERPINA4 Gene:

Hs.719893

mRNA Expression by UniProt/SwissProt for SERPINA4 Gene:

P29622-KAIN_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for SERPINA4 Gene

  • Intestine(4.3)
  • Bone marrow(4)
  • Liver(3.5)
  • Kidney(2.4)
  • Blood(2.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SERPINA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA4 Gene

Orthologs for SERPINA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA4 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia SERPINA4 33 34
  • 79.07 (n)
rat
(Rattus norvegicus)
Mammalia Serpina4 33
  • 67.99 (n)
cow
(Bos Taurus)
Mammalia SERPINA4 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA4 34
  • 52 (a)
OneToOne
Species where no ortholog for SERPINA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA4 Gene

ENSEMBL:
Gene Tree for SERPINA4 (if available)
TreeFam:
Gene Tree for SERPINA4 (if available)

Paralogs for SERPINA4 Gene

Pseudogenes.org Pseudogenes for SERPINA4 Gene

genes like me logo Genes that share paralogs with SERPINA4: view

Variants for SERPINA4 Gene

Sequence variations from dbSNP and Humsavar for SERPINA4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000254353 -- 94,562,098(+) C/T intron_variant
rs1000697150 -- 94,567,027(+) A/T coding_sequence_variant, missense_variant
rs1000765407 -- 94,567,545(+) C/T intron_variant
rs1000767838 -- 94,568,137(+) A/T coding_sequence_variant, missense_variant
rs1001565343 -- 94,561,296(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA4 Gene

Variant ID Type Subtype PubMed ID
esv3635384 CNV gain 21293372
nsv470662 CNV gain 18288195
nsv565623 CNV gain 21841781
nsv565625 CNV loss 21841781
nsv832865 CNV gain 17160897

Variation tolerance for SERPINA4 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA4 Gene

Disorders for SERPINA4 Gene

Additional Disease Information for SERPINA4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SERPINA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINA4 Gene

Publications for SERPINA4 Gene

  1. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. (PMID: 8227002) Chai KX … Chao L (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). (PMID: 7835886) Chai KX … Chao L (Genomics 1994) 3 4 22 58
  3. Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. (PMID: 1334488) Zhou GX … Chao J (The Journal of biological chemistry 1992) 3 4 22 58
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SERPINA4 Gene

Sources for SERPINA4 Gene

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