Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINA12 Gene

Aliases for SERPINA12 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12 2 3
  • Visceral Adipose Tissue-Derived Serine Protease Inhibitor 3 4
  • Vaspin 3 4
  • OL-64 3 4
  • Visceral Adipose-Specific SERPIN 3
  • Visceral Adipose-Specific Serpin 4
  • Serpin A12 3

External Ids for SERPINA12 Gene

Summaries for SERPINA12 Gene

GeneCards Summary for SERPINA12 Gene

SERPINA12 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12) is a Protein Coding gene. Diseases associated with SERPINA12 include obesity. Among its related pathways are IL-9 Signaling Pathways. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA12 Gene

  • Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA12 Gene

Genomics for SERPINA12 Gene

Genomic Location for SERPINA12 Gene

Start:
94,487,274 bp from pter
End:
94,517,844 bp from pter
Size:
30,571 bases
Orientation:
Minus strand

Genomic View for SERPINA12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA12 Gene

Regulatory Elements for SERPINA12 Gene

Proteins for SERPINA12 Gene

  • Protein details for SERPINA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW75-SPA12_HUMAN
    Recommended name:
    Serpin A12
    Protein Accession:
    Q8IW75
    Secondary Accessions:

    Protein attributes for SERPINA12 Gene

    Size:
    414 amino acids
    Molecular mass:
    47175 Da
    Quaternary structure:
    • Forms a stable complex with KLK7.

    Three dimensional structures from OCA and Proteopedia for SERPINA12 Gene

neXtProt entry for SERPINA12 Gene

Proteomics data for SERPINA12 Gene at MOPED

Post-translational modifications for SERPINA12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINA12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINA12 Gene

Domains for SERPINA12 Gene

Gene Families for SERPINA12 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SPA12_HUMAN
Domain:
  • The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).:
    • Q8IW75
Family:
  • Belongs to the serpin family.:
    • Q8IW75
genes like me logo Genes that share domains with SERPINA12: view

Function for SERPINA12 Gene

Molecular function for SERPINA12 Gene

UniProtKB/Swiss-Prot Function: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.

Gene Ontology (GO) - Molecular Function for SERPINA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SERPINA12: view

Phenotypes for SERPINA12 Gene

GenomeRNAi human phenotypes for SERPINA12:
genes like me logo Genes that share phenotypes with SERPINA12: view

miRNA for SERPINA12 Gene

miRTarBase miRNAs that target SERPINA12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERPINA12 Gene

Localization for SERPINA12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA12 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA12 Gene COMPARTMENTS Subcellular localization image for SERPINA12 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SERPINA12: view

Pathways for SERPINA12 Gene

SuperPathways for SERPINA12 Gene

genes like me logo Genes that share pathways with SERPINA12: view

Pathways by source for SERPINA12 Gene

1 R&D Systems pathway for SERPINA12 Gene

Interacting Proteins for SERPINA12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342109%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000053867%0d%0a9606.ENSP00000371067%0d%0a
Selected Interacting proteins: ENSP00000342109 for SERPINA12 Gene via STRING

Gene Ontology (GO) - Biological Process for SERPINA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
GO:0030162 regulation of proteolysis --
GO:0045721 negative regulation of gluconeogenesis IEA --
GO:0046628 positive regulation of insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SERPINA12: view

Compounds for SERPINA12 Gene

(2) Novoseek inferred chemical compound relationships for SERPINA12 Gene

Compound -log(P) Hits PubMed IDs
glucose 46.4 14
serine 38.6 9
genes like me logo Genes that share compounds with SERPINA12: view

Transcripts for SERPINA12 Gene

mRNA/cDNA for SERPINA12 Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINA12 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:

Relevant External Links for SERPINA12 Gene

GeneLoc Exon Structure for
SERPINA12
ECgene alternative splicing isoforms for
SERPINA12

Expression for SERPINA12 Gene

mRNA expression in normal human tissues for SERPINA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA12 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (32.0) and Skin - Not Sun Exposed (Suprapubic) (20.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINA12 Gene

SOURCE GeneReport for Unigene cluster for SERPINA12 Gene Hs.99476

mRNA Expression by UniProt/SwissProt for SERPINA12 Gene

Q8IW75-SPA12_HUMAN
Tissue specificity: Expressed in visceral adipose tissues.
genes like me logo Genes that share expressions with SERPINA12: view

Orthologs for SERPINA12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA12 36
  • 99.52 (n)
  • 99.52 (a)
SERPINA12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINA12 36
  • 76.89 (n)
  • 66.43 (a)
SERPINA12 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINA12 36
  • 77.32 (n)
  • 67.55 (a)
SERPINA12 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina12 36
  • 70.54 (n)
  • 61.5 (a)
Serpina12 16
Serpina12 37
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINA12 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA12 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina12 36
  • 71.34 (n)
  • 62.56 (a)
chicken
(Gallus gallus)
Aves SERPINA12 37
  • 35 (a)
OneToOne
SERPINA3 36
  • 52.91 (n)
  • 39.07 (a)
lizard
(Anolis carolinensis)
Reptilia SERPINA12 37
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR559930.2 37
  • 28 (a)
ManyToMany
serpina1 37
  • 31 (a)
ManyToMany
serpina1l 37
  • 31 (a)
ManyToMany
serpina7 37
  • 30 (a)
ManyToMany
si:ch211-186e20.2 37
  • 28 (a)
ManyToMany
si:ch211-186e20.7 37
  • 28 (a)
ManyToMany
zgc:174259 37
  • 29 (a)
ManyToMany
zgc:174260 37
  • 30 (a)
ManyToMany
Species with no ortholog for SERPINA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA12 Gene

ENSEMBL:
Gene Tree for SERPINA12 (if available)
TreeFam:
Gene Tree for SERPINA12 (if available)

Paralogs for SERPINA12 Gene

genes like me logo Genes that share paralogs with SERPINA12: view

Variants for SERPINA12 Gene

Sequence variations from dbSNP and Humsavar for SERPINA12 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs715216 -- 94,516,861(+) GTGAT(A/G)AAATG intron-variant
rs1012808 -- 94,494,749(-) AAACA(C/T)ATCCA intron-variant
rs1022701 -- 94,493,273(-) AGGGA(A/G)TTACA intron-variant
rs1243220 -- 94,494,098(-) CGTAG(A/G)ACTCA intron-variant
rs1951007 -- 94,503,359(-) AGGAA(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA12 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832863 CNV Gain 17160897
nsv832864 CNV Loss 17160897
nsv510649 CNV Loss 20534489
nsv832865 CNV Gain 17160897

Relevant External Links for SERPINA12 Gene

HapMap Linkage Disequilibrium report
SERPINA12
Human Gene Mutation Database (HGMD)
SERPINA12

Disorders for SERPINA12 Gene

(1) MalaCards Diseases for SERPINA12 Gene

Search for SERPINA12 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SERPINA12 Gene

(5) Novoseek inferred disease relationships for SERPINA12 Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 66.6 17
insulin resistance 63.8 7
obesity 60.9 15
atherosclerosis 11 3
inflammation 8.76 3

Relevant External Links for SERPINA12

Genetic Association Database (GAD)
SERPINA12
Human Genome Epidemiology (HuGE) Navigator
SERPINA12
genes like me logo Genes that share disorders with SERPINA12: view

No data available for UniProtKB/Swiss-Prot for SERPINA12 Gene

Publications for SERPINA12 Gene

  1. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. (PMID: 16030142) Hida K. … Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  2. Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies. (PMID: 18726871) Kempf K. … Vollmert C. (Exp. Clin. Endocrinol. Diabetes 2010) 3 23 49
  3. Vaspin serum concentrations in patients with carotid stenosis. (PMID: 18848328) Aust G. … BlA1her M. (Atherosclerosis 2009) 3 23
  4. Serum vaspin concentrations in human obesity and type 2 diabetes. (PMID: 17991760) Youn B.S. … BlA1her M. (Diabetes 2008) 3 23
  5. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. (PMID: 18375437) Tan B.K. … Randeva H.S. (Diabetes 2008) 3 23

Products for SERPINA12 Gene

Sources for SERPINA12 Gene

Back to Top

Content