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SERPINA12 Gene

protein-coding   GIFtS: 55
GCID: GC14M094954

Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
  See SERPINA12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 121 2
     OL-642 3
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1
Antiproteinase, Antitrypsin), Member 121 2
     Serpin A122
Visceral Adipose Tissue-Derived Serine Protease Inhibitor2 3     vaspin2
Visceral Adipose-Specific Serpin2 3     Vaspin3

External Ids:    HGNC: 183591   Entrez Gene: 1452642   Ensembl: ENSG000001659537   UniProtKB: Q8IW753   

Export aliases for SERPINA12 gene to outside databases

Previous GC identifers: GC14M092944 GC14M094023 GC14M075133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERPINA12 Gene:
SERPINA12 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12) is a protein-coding gene. Diseases associated with SERPINA12 include insulin resistance, and obesity. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPING1.

UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
Function: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white
adipose tissues




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERPINA12 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   oct-B3   POU2F2   POU2F2C   POU2F1   POU2F1a   ZID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINA12 promoter sequence
   Search Chromatin IP Primers for SERPINA12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERPINA12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

SERPINA12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA12 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094954:  view genomic region     (about GC identifiers)

Start:
94,953,611 bp from pter      End:
94,984,181 bp from pter
Size:
30,571 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75 (See protein sequence)
Recommended Name: Serpin A12 precursor  
Size: 414 amino acids; 47175 Da
Subunit: Forms a stable complex with KLK7
1 PDB 3D structure from and Proteopedia for SERPINA12:
4IF8 (3D)    

Explore the universe of human proteins at neXtProt for SERPINA12: NX_Q8IW75

Explore proteomics data for SERPINA12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERPINA12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776249.1  
    ENSEMBL proteins: 
     ENSP00000451738   ENSP00000342109  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SERPIN: Serine (or cysteine) peptidase inhibitors

    2 InterPro protein domains:
     IPR000215 Serpin_fam
     IPR023796 Serpin_dom

    Graphical View of Domain Structure for InterPro Entry Q8IW75

    ProtoNet protein and cluster: Q8IW75

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
    Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target
    protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage
    between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting
    inactive serpin-protease complex is highly stable (By similarity)
    Similarity: Belongs to the serpin family


    Find genes that share domains with SERPINA12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPA12_HUMAN, Q8IW75
    Function: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white
    adipose tissues

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
         
    Find genes that share ontologies with SERPINA12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINA12:
     Increased circadian period len  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERPINA12
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    miRNA
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    miRTarBase miRNAs that target SERPINA12:
    hsa-mir-186-5p (MIRT045039)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPA12_HUMAN, Q8IW75: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum3
    extracellular3
    golgi apparatus2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with SERPINA12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERPINA12 About    
    See pathways by source

    SuperPathContained pathways About
    1IL-9 Signaling Pathways
    Adipocytokines and Insulin Signaling0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SERPINA12
        Adipocytokines & Insulin Signaling




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERPINA12
    Interactions:

        Search GeneGlobe Interaction Network for SERPINA12

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    Find genes that share ontologies with SERPINA12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERPINA12 (SPA12)

    2 Novoseek inferred chemical compound relationships for SERPINA12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 46.4 19 17991760 (2), 17956947 (2), 19506980 (2), 19951565 (2) (see all 10)
    serine 38.6 18 18652756 (2), 16030142 (2), 18375437 (1), 19114623 (1) (see all 7)



    Find genes that share compounds with SERPINA12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERPINA12 gene: 
    NM_173850.2  

    Unigene Cluster for SERPINA12:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
    Hs.99476  [show with all ESTs]
    Unigene Representative Sequence: NM_173850
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556881 ENST00000341228(uc001ydj.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SERPINA12

    Additional mRNA sequence: 

    AY177692.1 AY326420.1 BC040857.1 

    2 DOTS entries:

    DT.101956041  DT.202724 

    9 AceView cDNA sequences:

    AY177692 AY326420 AA455546 BC040857 NM_173850 BM479041 BX498738 AA458648 
    BE140448 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -                                 
    SP2:                                                      


    ECgene alternative splicing isoforms for SERPINA12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERPINA12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACACCAC
    SERPINA12 Expression
    About this image


    SERPINA12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    SERPINA12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERPINA12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99476

    UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
    Tissue specificity: Expressed in visceral adipose tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINA12 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpina121 , 5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 more1, 5 70.54(n)1
    61.5(a)1
      12 (53.05 cM)5
    680541  NM_026535.21  NP_080811.11 
     1040287695 
    chicken
    (Gallus gallus)
    Aves SERPINA31 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, more 52.91(n)
    39.07(a)
      772339  XM_004941926.1  XP_004941983.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINA126
    serpin peptidase inhibitor, clade A (alpha-1 antip...
    34(a)
    1 ↔ 1
    1(6525451-6586044)
    zebrafish
    (Danio rerio)
    Actinopterygii serpina1l6
    serpina16
    (see all 8)
    serine (or cysteine) proteinase inhibitor, clade A...
    serine (or cysteine) proteinase inhibitor, clade A...
    (see all 8)
    31(a)
    31(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    20(10725111-10728283) ENSDARG00000090850
    20(10731186-10734497) ENSDARG00000090286


    ENSEMBL Gene Tree for SERPINA12 (if available)
    TreeFam Gene Tree for SERPINA12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERPINA12 gene
    SERPING12  SERPINA12  SERPINA102  SERPINA112  SERPINA72  SERPINA92  SERPINF12  SERPINA52  
    SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
    Selected SIMAP similar genes for SERPINA12 using alignment to 1 protein entry:     SPA12_HUMAN(see all similar genes):
    SERPINA1    SERPINA6    SERPINA11    SERPINA9    SERPINA3    SERPINA4
    SERPINA7    SERPINA5    SERPINB6    SERPINB8    SERPINI1    SERPINB4
    SERPINA10    SERPINB11    SERPINB9    SERPINI2    SERPINA2P    SERPINB1

    Find genes that share paralogs with SERPINA12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERPINA12 (see all 842)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382091551,2
    C,Funtested175944633(+) TCTGTG/ACTCCG 2 /A /V mis12Minor allele frequency- A:0.00NA EU 5875
    rs740758041,2
    C--75167126(+) CATAAT/GTAATA 1 -- us2k13Minor allele frequency- G:0.22WA NA 240
    rs2014624341,2
    --75167134(+) ATAAT-/TAAG  
            
    TAATT
    1 -- us2k10--------
    rs1399226771,2
    --75167197(+) AAAGTA/TCTTTA 1 -- us2k10--------
    rs740777201,2
    C,F--75943987(+) GGACCG/AACTTT 1 -- int13Minor allele frequency- A:0.15WA CSA 122
    rs1414809101,2
    --75944148(+) CAGGTA/CCTTGC 1 -- int10--------
    rs784768461,2
    C,F--75944299(+) GGGTGG/CGGCAT 1 -- int11Minor allele frequency- C:0.12NA 120
    rs65754351,2
    C,F,A--75944301(+) GTGGGG/ACATTG 1 -- int12Minor allele frequency- A:0.20WA 120
    rs1426156051,2
    --75944377(+) TCATTC/TGGGCT 1 -- int10--------
    rs2016816291,2
    C--75944492(+) GGCAAA/GCAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERPINA12 (94953611 - 94984181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SERPINA12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510649CNV Loss20534489
    nsv832864CNV Loss17160897
    nsv832865CNV Gain17160897
    nsv470662CNV Gain18288195
    nsv832863CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINA12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for SERPINA12:    
    About MalaCards
    insulin resistance    obesity

    1 disease from the University of Copenhagen DISEASES database for SERPINA12:
    Diabetes mellitus

    Find genes that share disorders with SERPINA12           About GenesLikeMe

    5 Novoseek inferred disease relationships for SERPINA12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 66.6 18 17991760 (3), 19356820 (3), 19952124 (2), 19506980 (2) (see all 11)
    insulin resistance 63.8 8 20018186 (3), 18652756 (1), 17970534 (1), 19952124 (1) (see all 5)
    obesity 60.9 18 18652756 (3), 16030142 (3), 17991760 (2), 19356820 (1) (see all 10)
    atherosclerosis 11 3 18848328 (2), 20145358 (1)
    inflammation 8.76 2 17956947 (1), 19801900 (1), 20045145 (1)

    Genetic Association Database (GAD): SERPINA12
    Human Genome Epidemiology (HuGE) Navigator: SERPINA12 (5 documents)

    Export disorders for SERPINA12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERPINA12 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with SERPINA12)
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    1. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. (PubMed id 16030142)1, 2, 9 Hida K.... Kanwar Y.S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies. (PubMed id 18726871)1, 4, 9 Kempf K....Vollmert C. (amp 2010)
    3. Vaspin inhibits kallikrein 7 by serpin mechanism. (PubMed id 23370777)1, 2 Heiker J.T....Beck-Sickinger A.G. (Cell. Mol. Life Sci. 2013)
    4. Update of the human and mouse SERPIN gene superfamily. (PubMed id 24172014)1, 3 Heit C....Vasiliou V. (Hum. Genomics 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status. (PubMed id 19554505)1, 9 Caminos J.E....DiAcguez C. (Histol. Histopathol. 2009)
    9. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. (PubMed id 18375437)1, 9 Tan B.K....Randeva H.S. (Diabetes 2008)
    10. Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes. (PubMed id 19951565)1, 9 Ye Y....Jia W.P. (Chin. Med. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145264 HGNC: 18359 AceView: SERPINA12 Ensembl:ENSG00000165953 euGenes: HUgn145264
    ECgene: SERPINA12 H-InvDB: SERPINA12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERPINA12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINA12 gene:
    Search GeneIP for patents involving SERPINA12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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