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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINA12 Gene

protein-coding   GIFtS: 55
GCID: GC14M094954

Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 121 2
     OL-642 3
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1
Antiproteinase, Antitrypsin), Member 121 2
     Serpin A122
Visceral Adipose Tissue-Derived Serine Protease Inhibitor2 3     vaspin2
Visceral Adipose-Specific Serpin2 3     Vaspin3

External Ids:    HGNC: 183591   Entrez Gene: 1452642   Ensembl: ENSG000001659537   UniProtKB: Q8IW753   

Export aliases for SERPINA12 gene to outside databases

Previous GC identifers: GC14M092944 GC14M094023 GC14M075133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINA12 Gene: 
SERPINA12 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12) is a protein-coding gene. Diseases associated with SERPINA12 include carotid stenosis, and gestational diabetes, and among its related super-pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPING1.

UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
Function: May modulate insulin action conceivably only in the presence of its yet undefined target proteases in
white adipose tissues




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINA12 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   oct-B3   POU2F2   POU2F2C   POU2F1   POU2F1a   ZID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINA12 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINA12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

SERPINA12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA12 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094954:  view genomic region     (about GC identifiers)

Start:
94,953,611 bp from pter      End:
94,984,181 bp from pter
Size:
30,571 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75 (See protein sequence)
Recommended Name: Serpin A12 precursor  
Size: 414 amino acids; 47175 Da
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for SERPINA12:
4IF8 (3D)    

Explore the universe of human proteins at neXtProt for SERPINA12: NX_Q8IW75

Explore proteomics data for SERPINA12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IW75

  • SERPINA12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINA12 Protein Expression
    REFSEQ proteins: NP_776249.1  
    ENSEMBL proteins: 
     ENSP00000451738   ENSP00000342109  

    Human Recombinant Protein Products for SERPINA12: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SERPINA12
    OriGene MassSpec for SERPINA12 
    OriGene Custom Protein Services for SERPINA12
    GenScript Custom Purified and Recombinant Proteins Services for SERPINA12
    Novus Biologicals SERPINA12 Proteins
    Novus Biologicals SERPINA12 Lysate
    Sino Biological Recombinant Protein for SERPINA12
    Sino Biological Cell Lysate for SERPINA12 
    ProSpec Recombinant Protein for SERPINA12
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    SERPINA12 for ontologies           About GeneDecksing



    SERPINA12 Antibody Products: 
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    Abcam antibodies for SERPINA12
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    LSBio Antibodies in human, mouse, rat for SERPINA12 

    Assay Products for SERPINA12: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SERPINA12
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    2 InterPro protein domains:
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry Q8IW75

    ProtoNet protein and cluster: Q8IW75

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
    Similarity: Belongs to the serpin family


    SERPINA12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPA12_HUMAN, Q8IW75
    Function: May modulate insulin action conceivably only in the presence of its yet undefined target proteases in
    white adipose tissues

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
         
    SERPINA12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINA12:
     Increased circadian period len  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINA12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINA12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINA12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINA12 

    miRNA
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SERPINA12

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERPINA12 (NM_173850)
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINA12 

    Cell Line
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    Search LifeMap BioReagents cell lines for SERPINA12
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERPINA12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    Adipocytokines & Insulin Signaling0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SERPINA12
        Adipocytokines & Insulin Signaling




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINA12

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--

    SERPINA12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINA12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINA12 (SPA12)

    2 Novoseek inferred chemical compound relationships for SERPINA12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 46.4 19 17991760 (2), 17956947 (2), 19506980 (2), 19951565 (2) (see all 10)
    serine 38.6 18 18652756 (2), 16030142 (2), 18375437 (1), 19114623 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about SERPINA12 / SPA12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINA12 gene: 
    NM_173850.2  

    Unigene Cluster for SERPINA12:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
    Hs.99476  [show with all ESTs]
    Unigene Representative Sequence: NM_173850
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556881 ENST00000341228(uc001ydj.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERPINA12
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINA12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINA12
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINA12 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINA12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINA12

    Additional mRNA sequence: 

    AY177692.1 AY326420.1 BC040857.1 

    2 DOTS entries:

    DT.101956041  DT.202724 

    9 AceView cDNA sequences:

    AA455546 BC040857 AY177692 AY326420 NM_173850 AA458648 BM479041 BX498738 
    BE140448 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -                                 
    SP2:                                                      


    ECgene alternative splicing isoforms for SERPINA12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINA12 expression in normal human tissues (normalized intensities)      SERPINA12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACACCAC
    SERPINA12 Expression
    About this image


    SERPINA12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule

     -- (Integumentary System)
             skin   

    See SERPINA12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINA12

    SOURCE GeneReport for Unigene cluster: Hs.99476

    UniProtKB/Swiss-Prot: SPA12_HUMAN, Q8IW75
    Tissue specificity: Expressed in visceral adipose tissues

        SABiosciences Custom PCR Arrays for SERPINA12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SERPINA12 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpina121 , 5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 more1, 5 70.54(n)1
    61.5(a)1
      12 (53.05 cM)5
    680541  NM_026535.21  NP_080811.11 
     1040287695 
    chicken
    (Gallus gallus)
    Aves SERPINA121 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, more 56.06(n)
    41.76(a)
      428905  XM_426460.3  XP_426460.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    Uncharacterized protein
    (see all 7)
    38(a)
    38(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    1(6446197-6452624)
    1(6423405-6428473)


    ENSEMBL Gene Tree for SERPINA12 (if available)
    TreeFam Gene Tree for SERPINA12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINA12 gene
    SERPING12  SERPINA12  SERPINH12  SERPINA102  SERPINA112  SERPINA72  SERPINA92  SERPINF12  
    SERPINA52  SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
    18/25 SIMAP similar genes for SERPINA12 using alignment to 1 protein entry:     SPA12_HUMAN(see all similar genes):
    SERPINA1    SERPINA6    SERPINA11    SERPINA9    SERPINA3    SERPINA4
    SERPINA7    SERPINA5    SERPINB6    SERPINB8    SERPINI1    SERPINB4
    SERPINA10    SERPINB11    SERPINB9    SERPINI2    SERPINA2P    SERPINB1

    SERPINA12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/842 SNPs in SERPINA12 are shown (see all 842)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382091551,2
    C,Funtested175944633(+) TCTGTG/ACTCCG 2 /A /V mis12Minor allele frequency- A:0.00NA EU 5875
    rs740758041,2
    C--75167126(+) CATAAT/GTAATA 1 -- us2k13Minor allele frequency- G:0.22WA NA 240
    rs2014624341,2
    --75167134(+) ATAAT-/TAAG  
            
    TAATT
    1 -- us2k10--------
    rs1399226771,2
    --75167197(+) AAAGTA/TCTTTA 1 -- us2k10--------
    rs740777201,2
    C,F--75943987(+) GGACCG/AACTTT 1 -- int13Minor allele frequency- A:0.15WA CSA 122
    rs1414809101,2
    --75944148(+) CAGGTA/CCTTGC 1 -- int10--------
    rs784768461,2
    C,F--75944299(+) GGGTGG/CGGCAT 1 -- int11Minor allele frequency- C:0.12NA 120
    rs65754351,2
    C,F,A--75944301(+) GTGGGG/ACATTG 1 -- int12Minor allele frequency- A:0.20WA 120
    rs1426156051,2
    --75944377(+) TCATTC/TGGGCT 1 -- int10--------
    rs2016816291,2
    C--75944492(+) GGCAAA/GCAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERPINA12 (94953611 - 94984181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SERPINA12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510649CNV Loss20534489
    nsv832864CNV Loss17160897
    nsv832865CNV Gain17160897
    nsv470662CNV Gain18288195
    nsv832863CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERPINA12
    DNA2.0 Custom Variant and Variant Library Synthesis for SERPINA12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    18 diseases for SERPINA12:    About MalaCards
    carotid stenosis    gestational diabetes    fatty liver disease    obesity, association with
    insulin resistance    polycystic ovary syndrome    hypothyroidism    obesity
    atherosclerosis    liver disease    kawasaki disease    diabetes mellitus
    alcoholism    psoriasis    endotheliitis    hepatitis c
    arthritis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SERPINA12:
    Diabetes mellitus

    SERPINA12 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SERPINA12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 66.6 18 17991760 (3), 19356820 (3), 19952124 (2), 19506980 (2) (see all 11)
    insulin resistance 63.8 8 20018186 (3), 18652756 (1), 17970534 (1), 19952124 (1) (see all 5)
    obesity 60.9 18 18652756 (3), 16030142 (3), 17991760 (2), 19356820 (1) (see all 10)
    atherosclerosis 11 3 18848328 (2), 20145358 (1)
    inflammation 8.76 2 17956947 (1), 19801900 (1), 20045145 (1)

    Genetic Association Database (GAD): SERPINA12
    Human Genome Epidemiology (HuGE) Navigator: SERPINA12 (5 documents)

    Export disorders for SERPINA12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINA12 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with SERPINA12)
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    1. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. (PubMed id 16030142)1, 2, 9 Hida K.... Kanwar Y.S. (2005)
    2. Vaspin (SERPINA12) Genotypes and Risk of Type 2 Diabetes: Results from the MONICA/KORA studies. (PubMed id 18726871)1, 4, 9 Kempf K....Vollmert C. (2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Vaspin and amylin are expressed in human and rat plac enta and regulated by nutritional status. (PubMed id 19554505)1, 9 Caminos J.E....DiAcguez C. (2009)
    8. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. (PubMed id 18375437)1, 9 Tan B.K....Randeva H.S. (2008)
    9. Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes. (PubMed id 19951565)1, 9 Ye Y....Jia W.P. (2009)
    10. Circulating vaspin is unrelated to insulin sensitivit y in a cohort of nondiabetic humans. (PubMed id 19952124)1, 9 von Loeffelholz C....Weickert M.O. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145264 HGNC: 18359 AceView: SERPINA12 Ensembl:ENSG00000165953 euGenes: HUgn145264
    ECgene: SERPINA12 H-InvDB: SERPINA12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINA12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERPINA12 gene:
    Search GeneIP for patents involving SERPINA12

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