SERPINA11 Gene
protein-coding GIFtS: 36
GCID: GC14M094908
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serpin peptidase inhibitor, clade A (alpha-1 antiproteinase,...(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
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Aliases
for SERPINA11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin),Member 111 2 | | Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase,Antitrypsin), Member 111 2 | | Antiproteinase-Like 22 | | Serpin A112 |
Export aliases for SERPINA11 gene to outside databasesPrevious GC identifers: GC14U900167 GC14M092919 GC14M092899 GC14M093979 GC14M075089 |
Summaries
for SERPINA11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SERPINA11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERPINA11 gene promoter:
E2F-3a E2F-4 E2F-5 p53 E2F-2 IRF-2 E2F-1 E2F IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERPINA11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.13 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.13SERPINA11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M094908: view genomic region
(about GC identifiers)
Start:
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94,908,801 bp from pter |
End:
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94,919,127 bp from pter |
Size:
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10,327 bases |
Orientation:
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minus strand |
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Proteins
for SERPINA11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPA11_HUMAN, Q86U17 (See
protein sequence)Recommended Name: Serpin A11 precursor Size: 422 amino acids; 46989 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=CAD62587.1; Type=Erroneous initiation;
Secondary accessions: B2RV07Explore the universe of human proteins at neXtProt for SERPINA11: NX_Q86U17
SERPINA11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073920.1
ENSEMBL proteins: ENSP00000335024
Human Recombinant Protein Products for SERPINA11:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
SERPINA11 for ontologies About GeneDecksing
SERPINA11 Antibody Products:
Assay Products for SERPINA11: |
Protein
Domains /
Families
for SERPINA11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERPINA11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86U17ProtoNet protein and cluster: Q86U17 1 Blocks protein family: IPB000215 Serpin
UniProtKB/Swiss-Prot: SPA11_HUMAN, Q86U17Similarity: Belongs to the serpin family |
Function
for SERPINA11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004867 | serine-type endopeptidase inhibitor activity |
IBA | -- |
SERPINA11 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERPINA11 (NM_001080451) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINA11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINA11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA11 |
|
Pathways & Interactions
for SERPINA11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINA11
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0010951 | negative regulation of endopeptidase activity |
IBA | -- | | GO:0030162 | regulation of proteolysis |
IBA | -- |
SERPINA11 for ontologies About GeneDecksing
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Drugs & Compounds
for SERPINA11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERPINA11
Search CenterWatch for drugs/clinical trials and news about SERPINA11 / SPA11
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Transcripts
for SERPINA11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERPINA11 gene: NM_001080451.1 Unigene Cluster for SERPINA11: Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 Hs.145890 [show with all ESTs]Unigene Representative Sequence: NM_0010804511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000334708(uc001ydd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERPINA11 (NM_001080451) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERPINA11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINA11 |
Additional cDNA sequence: BC146962.1 BX248259.1 1 DOTS entry: DT.433109 10 AceView cDNA sequences: AI133094 BX248259 AA337229 AA337234 BX463052 AA334524 BX463051 AI274750 AA337774 AI652967
GeneLoc Exon Structure
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Expression
for SERPINA11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERPINA11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGAGAAGG
About this image
See SERPINA11 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.145890
SABiosciences Custom PCR Arrays for SERPINA11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINA11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERPINA11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINA11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINA11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA11 |
Orthologs
for SERPINA11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SERPINA11 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SERPINA11 (if available)
TreeFam Gene Tree for SERPINA11 (if available) |
Paralogs
for SERPINA11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERPINA11 gene
- SERPING12 SERPINA12 SERPINH12 SERPINA102 SERPINA72 SERPINA122 SERPINA92 SERPINA52
- SERPINF12 SERPIND12 SERPINA42 SERPINA32 SERPINA62 SERPINF22
18/25 SIMAP similar genes for SERPINA11 using alignment to 1 protein entry: SPA11_HUMAN(see all similar genes):SERPINA4 SERPINA7 SERPINA9 SERPINA3 SERPINA1 SERPINA12
SERPINA6 SERPINA5 SERPINI1 SERPINI2 SERPINA13P SERPINA2P
SERPINB3 SERPINB4 DKFZp686D06190 DKFZp686O07189 SCCA2 SERPINB10
SERPINA11 for paralogs About GeneDecksing
|
Genomic Variants
for SERPINA11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERPINA11 (94908801 - 94919127 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERPINA11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINA11 |
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Disorders
/ Diseases
for SERPINA11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SERPINA11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERPINA11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERPINA11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)1, 3 Namciu S.J....Fournier R.E. (2004)
- Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SERPINA11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SERPINA11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SERPINA11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERPINA11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERPINA11 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SERPINA11 gene:
Search GeneIP for patents involving SERPINA11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERPINA11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERPINA11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERPINA11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERPINA11 | | | OriGene Protein Over-expression Lysate for SERPINA11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SERPINA11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERPINA11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SERPINA11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERPINA11 | | OriGene Custom Protein Services for SERPINA11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERPINA11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERPINA11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERPINA11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINA11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINA11 |
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 | | | SERPINA11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA11 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERPINA11 |
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