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Aliases for SERPINA11 Gene

Aliases for SERPINA11 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2

External Ids for SERPINA11 Gene

Previous GeneCards Identifiers for SERPINA11 Gene

  • GC14U900167
  • GC14M092919
  • GC14M092899
  • GC14M093979
  • GC14M094908
  • GC14M075089

Summaries for SERPINA11 Gene

GeneCards Summary for SERPINA11 Gene

SERPINA11 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA11 Gene

Genomics for SERPINA11 Gene

Regulatory Elements for SERPINA11 Gene

Genomic Location for SERPINA11 Gene

Start:
94,442,462 bp from pter
End:
94,452,834 bp from pter
Size:
10,373 bases
Orientation:
Minus strand

Genomic View for SERPINA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA11 Gene

Proteins for SERPINA11 Gene

  • Protein details for SERPINA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U17-SPA11_HUMAN
    Recommended name:
    Serpin A11
    Protein Accession:
    Q86U17
    Secondary Accessions:
    • B2RV07

    Protein attributes for SERPINA11 Gene

    Size:
    422 amino acids
    Molecular mass:
    46989 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA11 Gene

Proteomics data for SERPINA11 Gene at MOPED

Post-translational modifications for SERPINA11 Gene

  • Glycosylation at Asn94, Asn106, Asn169, and Asn350

Other Protein References for SERPINA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SERPINA11 (Serpin A11)

No data available for DME Specific Peptides for SERPINA11 Gene

Domains for SERPINA11 Gene

Gene Families for SERPINA11 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U17

UniProtKB/Swiss-Prot:

SPA11_HUMAN :
  • Q86U17
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA11: view

Function for SERPINA11 Gene

Gene Ontology (GO) - Molecular Function for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with SERPINA11: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINA11
    • Block miRNA regulation of SERPINA11 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA11

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA11 Gene

    Localization for SERPINA11 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for SERPINA11 Gene

    Secreted.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for SERPINA11 Gene COMPARTMENTS Subcellular localization image for SERPINA11 gene
    Compartment Confidence
    extracellular 3
    cytosol 1
    endoplasmic reticulum 1
    lysosome 1
    mitochondrion 1
    peroxisome 1

    Gene Ontology (GO) - Cellular Components for SERPINA11 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005615 extracellular space IBA --
    genes like me logo Genes that share ontologies with SERPINA11: view

    Pathways for SERPINA11 Gene

    SuperPathways for SERPINA11 Gene

    No Data Available

    Interacting Proteins for SERPINA11 Gene

    Gene Ontology (GO) - Biological Process for SERPINA11 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0010951 negative regulation of endopeptidase activity IBA --
    GO:0030162 regulation of proteolysis --
    genes like me logo Genes that share ontologies with SERPINA11: view

    No data available for Pathways by source for SERPINA11 Gene

    Transcripts for SERPINA11 Gene

    mRNA/cDNA for SERPINA11 Gene

    (10) Selected AceView cDNA sequences:
    (2) Additional mRNA sequences :
    (2) REFSEQ mRNAs :
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for SERPINA11 Gene

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINA11
      • Block miRNA regulation of SERPINA11 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA11

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SERPINA11

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA11 Gene

      No ASD Table

      Relevant External Links for SERPINA11 Gene

      GeneLoc Exon Structure for
      SERPINA11
      ECgene alternative splicing isoforms for
      SERPINA11

      Expression for SERPINA11 Gene

      mRNA expression in normal human tissues for SERPINA11 Gene

      mRNA differential expression in normal tissues according to GTEx for SERPINA11 Gene

      This gene is overexpressed in Liver (51.4).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINA11 Gene

      SOURCE GeneReport for Unigene cluster for SERPINA11 Gene Hs.145890

      genes like me logo Genes that share expressions with SERPINA11: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SERPINA11 Gene

      Orthologs for SERPINA11 Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for SERPINA11 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia SERPINA11 36
      • 100 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia SERPINA11 35
      • 84.44 (n)
      • 79.15 (a)
      SERPINA11 36
      • 79 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia SERPINA11 35
      • 84.6 (n)
      • 80.57 (a)
      SERPINA11 36
      • 81 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Serpina11 35
      • 79.3 (n)
      • 75.36 (a)
      Serpina11 16
      Serpina11 36
      • 74 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia SERPINA11 36
      • 53 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Serpina11 35
      • 76.86 (n)
      • 75.12 (a)
      Species with no ortholog for SERPINA11:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for SERPINA11 Gene

      ENSEMBL:
      Gene Tree for SERPINA11 (if available)
      TreeFam:
      Gene Tree for SERPINA11 (if available)

      Paralogs for SERPINA11 Gene

      genes like me logo Genes that share paralogs with SERPINA11: view

      Variants for SERPINA11 Gene

      Sequence variations from dbSNP and Humsavar for SERPINA11 Gene

      SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
      rs730383 -- 94,445,540(+) ttaaa(A/G)taGAA intron-variant
      rs743208 -- 94,446,180(-) ctcac(A/C)ttttt intron-variant
      rs744330 -- 94,445,563(+) AATAT(A/G)ATGAT intron-variant
      rs744331 -- 94,445,749(+) ttttt(A/C/T)aattt intron-variant
      rs761982 -- 94,452,126(-) GGGTG(C/T)TTCAA intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for SERPINA11 Gene

      Variant ID Type Subtype PubMed ID
      nsv470662 CNV Gain 18288195
      nsv832863 CNV Gain 17160897
      nsv832864 CNV Loss 17160897
      nsv510649 CNV Loss 20534489
      nsv1407 CNV Insertion 18451855

      Relevant External Links for SERPINA11 Gene

      HapMap Linkage Disequilibrium report
      SERPINA11

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA11 Gene

      Disorders for SERPINA11 Gene

      Relevant External Links for SERPINA11

      Genetic Association Database (GAD)
      SERPINA11
      genes like me logo Genes that share disorders with SERPINA11: view

      No data available for UniProtKB/Swiss-Prot for SERPINA11 Gene

      Publications for SERPINA11 Gene

      1. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu S.J. … Fournier R.E. (Mamm. Genome 2004) 2 3
      2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
      3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 48
      4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
      5. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons P.A. … Smith K.G. (N. Engl. J. Med. 2012) 3

      Products for SERPINA11 Gene

      Sources for SERPINA11 Gene

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