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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINA11 Gene

protein-coding   GIFtS: 39
GCID: GC14M094908

Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
  Search for SERPINA11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 111 2
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1
Antiproteinase, Antitrypsin), Member 111 2
Antiproteinase-Like 22
Serpin A112

External Ids:    HGNC: 191931   Entrez Gene: 2563942   Ensembl: ENSG000001869107   UniProtKB: Q86U173   

Export aliases for SERPINA11 gene to outside databases

Previous GC identifers: GC14U900167 GC14M092919 GC14M092899 GC14M093979 GC14M075089


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERPINA11 Gene: 
SERPINA11 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPING1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINA11 gene promoter:
         E2F-3a   E2F-4   E2F-5   p53   E2F-2   IRF-2   E2F-1   E2F   IRF-7A   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

SERPINA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094908:  view genomic region     (about GC identifiers)

Start:
94,908,801 bp from pter      End:
94,919,127 bp from pter
Size:
10,327 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPA11_HUMAN, Q86U17 (See protein sequence)
Recommended Name: Serpin A11 precursor  
Size: 422 amino acids; 46989 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=CAD62587.1; Type=Erroneous initiation;
Secondary accessions: B2RV07

Explore the universe of human proteins at neXtProt for SERPINA11: NX_Q86U17

Explore proteomics data for SERPINA11 at MOPED 

SERPINA11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SERPINA11 Protein Expression

REFSEQ proteins: NP_001073920.1  
ENSEMBL proteins: 
 ENSP00000335024  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

SERPINA11 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SERPIN: Serine (or cysteine) peptidase inhibitors

2 InterPro protein domains:
 IPR023796 Serpin_dom
 IPR000215 Serpin_fam

Graphical View of Domain Structure for InterPro Entry Q86U17

ProtoNet protein and cluster: Q86U17

1 Blocks protein domain: IPB000215 Serpin

UniProtKB/Swiss-Prot: SPA11_HUMAN, Q86U17
Similarity: Belongs to the serpin family


SERPINA11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IBA--
     
SERPINA11 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERPINA11

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010951negative regulation of endopeptidase activity IBA--
GO:0030162regulation of proteolysis IBA--

SERPINA11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERPINA11 (SPA11)

Search CenterWatch for drugs/clinical trials and news about SERPINA11 / SPA11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERPINA11 gene: 
NM_001080451.1  

Unigene Cluster for SERPINA11:

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Hs.145890  [show with all ESTs]
Unigene Representative Sequence: NM_001080451
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000334708(uc001ydd.1)
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Additional mRNA sequence: 

BC146962.1 BX248259.1 

1 DOTS entry:

DT.433109 

10 AceView cDNA sequences:

BX248259 AI133094 AA337229 AA334524 BX463052 AI274750 BX463051 AA337774 
AA337234 AI652967 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERPINA11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTGAGAAGG
SERPINA11 Expression
About this image


See SERPINA11 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.145890
    SABiosciences Custom PCR Arrays for SERPINA11
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SERPINA11 gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Serpina111 , 5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 more1, 5 79.3(n)1
75.36(a)1
  12 (52.98 cM)5
3807801  NM_199314.21  NP_955018.21 
 1039802435 


ENSEMBL Gene Tree for SERPINA11 (if available)
TreeFam Gene Tree for SERPINA11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SERPINA11 gene
SERPING12  SERPINA12  SERPINH12  SERPINA102  SERPINA72  SERPINA122  SERPINA92  SERPINF12  
SERPINA52  SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
18/25 SIMAP similar genes for SERPINA11 using alignment to 1 protein entry:     SPA11_HUMAN(see all similar genes):
SERPINA4    SERPINA7    SERPINA9    SERPINA1    SERPINA12    SERPINA3
SERPINA6    SERPINA5    SERPINI1    SERPINI2    SERPINA13P    SERPINA2P
SERPINB3    SERPINB4    DKFZp686D06190    DKFZp686O07189    SCCA2    SERPINB10

SERPINA11 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/415 SNPs in SERPINA11 are shown (see all 415)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs798118141,2
C--94908354(+) TGACAC/TGCTGT 1 -- ds50013Minor allele frequency- T:0.19CSA NA EA 242
rs1882152151,2
--94908398(+) GACCCA/GTGATT 1 -- ds50010--------
rs170908621,2
C,F,H--94908409(+) ACGCCG/AGCCCA 1 -- ds50018Minor allele frequency- A:0.08NA NS EA WA 544
rs1925303401,2
--94908467(+) CAGGTC/TCAACC 1 -- ds50010--------
rs1489742581,2
C--94908476(+) CCTCCC/TCTTGA 1 -- ds50010--------
rs1848089691,2
--94908527(+) ACAACC/TTCTCT 1 -- ds50010--------
rs1116337561,2
F--94908531(+) CCTCTG/CTTGTC 1 -- ds50012Minor allele frequency- C:0.50CSA 4
rs1883593321,2
--94908661(+) AGCAGC/TGGTGG 1 -- ds50010--------
rs1124339841,2
F--94908663(+) CAGCGC/GTGGAC 1 -- ds50012Minor allele frequency- G:0.33CSA 3
rs1913732871,2
--94908698(+) GGGTCA/GTTCTC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for SERPINA11 (94908801 - 94919127 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SERPINA11:    About this table     
Variant IDTypeSubtypePubMed ID
nsv1407CNV Insertion18451855
nsv510649CNV Loss20534489
nsv832864CNV Loss17160897
nsv470662CNV Gain18288195
nsv832863CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERPINA11 for disorders           About MalaCards

SERPINA11 for disorders           About GeneDecksing

Genetic Association Database (GAD): SERPINA11

Export disorders for SERPINA11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SERPINA11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERPINA11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)1, 3 Namciu S.J....Fournier R.E. (2004)
  2. Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
  3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 256394 HGNC: 19193 AceView: SERPINA11 Ensembl:ENSG00000186910 euGenes: HUgn256394
ECgene: SERPINA11 H-InvDB: SERPINA11

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SERPINA11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SERPINA11 gene:
Search GeneIP for patents involving SERPINA11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in SERPINA11 promoter
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINA11
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Customized:
 lentivirus for stable overexpression of SERPINA11
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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