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Aliases for SERPINA11 Gene

Aliases for SERPINA11 Gene

  • Serpin Family A Member 11 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2

External Ids for SERPINA11 Gene

Previous GeneCards Identifiers for SERPINA11 Gene

  • GC14U900167
  • GC14M092919
  • GC14M092899
  • GC14M093979
  • GC14M094908
  • GC14M075089

Summaries for SERPINA11 Gene

GeneCards Summary for SERPINA11 Gene

SERPINA11 (Serpin Family A Member 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA4.

Additional gene information for SERPINA11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA11 Gene

Genomics for SERPINA11 Gene

GeneHancer (GH) Regulatory Elements for SERPINA11 Gene

Promoters and enhancers for SERPINA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094450 Promoter/Enhancer 1.4 EPDnew ENCODE 563.6 +1.0 996 2.4 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF143 RXRA SP5 SERPINA11 ENSG00000256357
GH14I094597 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -147.4 -147354 6.1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 SERPINA10 SERPINA3 SERPINA1 SERPINA5 SCARNA13 SNHG10 DICER1 SERPINA6 SERPINA11 SERPINA4
GH14I094384 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +61.2 61208 15.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 SERPINA1 IFI27L2 SERPINA11 SERPINA9 ENSG00000256357 SERPINA2
GH14I094593 Enhancer 1.2 FANTOM5 ENCODE 17.8 -141.2 -141217 1.1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 SERPINA5 SERPINA1 SERPINA6 SERPINA11 SERPINA10 SERPINA3 SERPINA4 ENSG00000273259
GH14I094423 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.9 +29.2 29212 0.5 CTCF SAP130 ARID4B THRB RAD21 TEAD3 SMC3 ZNF143 ZNF444 MIXL1 SERPINA11 SERPINA1 ENSG00000256357
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINA11 gene promoter:

Genomic Locations for SERPINA11 Gene

Genomic Locations for SERPINA11 Gene
chr14:94,442,464-94,452,850
(GRCh38/hg38)
Size:
10,387 bases
Orientation:
Minus strand
chr14:94,908,801-94,919,127
(GRCh37/hg19)

Genomic View for SERPINA11 Gene

Genes around SERPINA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA11 Gene

Proteins for SERPINA11 Gene

  • Protein details for SERPINA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U17-SPA11_HUMAN
    Recommended name:
    Serpin A11
    Protein Accession:
    Q86U17
    Secondary Accessions:
    • B2RV07

    Protein attributes for SERPINA11 Gene

    Size:
    422 amino acids
    Molecular mass:
    46989 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA11 Gene

Post-translational modifications for SERPINA11 Gene

  • Glycosylation at posLast=9494, posLast=106106, posLast=169169, and isoforms=350

Other Protein References for SERPINA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINA11 Gene

Domains & Families for SERPINA11 Gene

Gene Families for SERPINA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SERPINA11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U17

UniProtKB/Swiss-Prot:

SPA11_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA11: view

Function for SERPINA11 Gene

Phenotypes From GWAS Catalog for SERPINA11 Gene

Gene Ontology (GO) - Molecular Function for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA11: view
genes like me logo Genes that share phenotypes with SERPINA11: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA11 Gene

Localization for SERPINA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA11 gene
Compartment Confidence
extracellular 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERPINA11 Gene

Pathways & Interactions for SERPINA11 Gene

SuperPathways for SERPINA11 Gene

No Data Available

Interacting Proteins for SERPINA11 Gene

Gene Ontology (GO) - Biological Process for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA11 Gene

Drugs & Compounds for SERPINA11 Gene

No Compound Related Data Available

Transcripts for SERPINA11 Gene

mRNA/cDNA for SERPINA11 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINA11 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA11 Gene

No ASD Table

Relevant External Links for SERPINA11 Gene

GeneLoc Exon Structure for
SERPINA11
ECgene alternative splicing isoforms for
SERPINA11

Expression for SERPINA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINA11 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA11 Gene

This gene is overexpressed in Liver (x51.4).

Protein differential expression in normal tissues from HIPED for SERPINA11 Gene

This gene is overexpressed in Serum (59.7) and Plasma (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINA11 Gene



Protein tissue co-expression partners for SERPINA11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERPINA11 Gene:

SERPINA11

SOURCE GeneReport for Unigene cluster for SERPINA11 Gene:

Hs.145890

Evidence on tissue expression from TISSUES for SERPINA11 Gene

  • Liver(2.3)
genes like me logo Genes that share expression patterns with SERPINA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA11 Gene

Orthologs for SERPINA11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA11 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINA11 33 34
  • 84.6 (n)
cow
(Bos Taurus)
Mammalia SERPINA11 33 34
  • 84.44 (n)
mouse
(Mus musculus)
Mammalia Serpina11 33 16 34
  • 79.3 (n)
rat
(Rattus norvegicus)
Mammalia Serpina11 33
  • 76.86 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINA11 34
  • 53 (a)
OneToOne
Species where no ortholog for SERPINA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA11 Gene

ENSEMBL:
Gene Tree for SERPINA11 (if available)
TreeFam:
Gene Tree for SERPINA11 (if available)

Paralogs for SERPINA11 Gene

Variants for SERPINA11 Gene

Sequence variations from dbSNP and Humsavar for SERPINA11 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000050003 -- 94,454,428(-) A/C upstream_transcript_variant
rs1000056043 -- 94,453,062(-) T/C upstream_transcript_variant
rs1000451141 -- 94,447,428(-) C/T intron_variant
rs1000851432 -- 94,442,119(-) C/T downstream_transcript_variant
rs1000918997 -- 94,447,721(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA11 Gene

Variant ID Type Subtype PubMed ID
dgv1963n100 CNV gain 25217958
dgv674e212 CNV gain 25503493
nsv1407 CNV insertion 18451855
nsv470662 CNV gain 18288195
nsv510649 CNV deletion 20534489
nsv565623 CNV gain 21841781
nsv832863 CNV gain 17160897
nsv832864 CNV loss 17160897

Variation tolerance for SERPINA11 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA11 Gene

Disorders for SERPINA11 Gene

Additional Disease Information for SERPINA11

No disorders were found for SERPINA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERPINA11 Gene

Publications for SERPINA11 Gene

  1. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C … Vasiliou V (Human genomics 2013) 2 3 58
  2. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu SJ … Fournier RE (Mammalian genome : official journal of the International Mammalian Genome Society 2004) 2 3 58
  3. Whole-exome sequencing analysis in twin sibling males with an anterior cruciate ligament rupture. (PMID: 27692106) Caso E … Guerado E (Injury 2016) 3 58
  4. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. (PMID: 24141781) Lin KT … Huang CY (Oncogene 2014) 3 58
  5. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons PA … Smith KG (The New England journal of medicine 2012) 3 58

Products for SERPINA11 Gene

Sources for SERPINA11 Gene

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