Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINA11 Gene

Aliases for SERPINA11 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2 3
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11 2

External Ids for SERPINA11 Gene

Summaries for SERPINA11 Gene

GeneCards Summary for SERPINA11 Gene

SERPINA11 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 11) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA11 Gene

Genomics for SERPINA11 Gene

Genomic Location for SERPINA11 Gene

Start:
94,442,462 bp from pter
End:
94,452,834 bp from pter
Size:
10,373 bases
Orientation:
Minus strand

Genomic View for SERPINA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA11 Gene

Regulatory Elements for SERPINA11 Gene

Proteins for SERPINA11 Gene

  • Protein details for SERPINA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U17-SPA11_HUMAN
    Recommended name:
    Serpin A11
    Protein Accession:
    Q86U17
    Secondary Accessions:
    • B2RV07

    Protein attributes for SERPINA11 Gene

    Size:
    422 amino acids
    Molecular mass:
    46989 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERPINA11 Gene

Proteomics data for SERPINA11 Gene at MOPED

Post-translational modifications for SERPINA11 Gene

  • Glycosylation at Asn94, Asn106, Asn169, and Asn350

Other Protein References for SERPINA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERPINA11 Gene

Domains for SERPINA11 Gene

Gene Families for SERPINA11 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U17

UniProtKB/Swiss-Prot:

SPA11_HUMAN
Family:
  • Belongs to the serpin family.:
    • Q86U17
genes like me logo Genes that share domains with SERPINA11: view

Function for SERPINA11 Gene

Gene Ontology (GO) - Molecular Function for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA11 Gene

Localization for SERPINA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA11 Gene COMPARTMENTS Subcellular localization image for SERPINA11 gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SERPINA11: view

Pathways for SERPINA11 Gene

SuperPathways for SERPINA11 Gene

No Data Available

Interacting Proteins for SERPINA11 Gene

Gene Ontology (GO) - Biological Process for SERPINA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINA11: view

No data available for Pathways by source for SERPINA11 Gene

Transcripts for SERPINA11 Gene

mRNA/cDNA for SERPINA11 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERPINA11 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA11 Gene

No ASD Table

Relevant External Links for SERPINA11 Gene

GeneLoc Exon Structure for
SERPINA11
ECgene alternative splicing isoforms for
SERPINA11

Expression for SERPINA11 Gene

mRNA expression in normal human tissues for SERPINA11 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA11 Gene

This gene is overexpressed in Liver (51.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINA11 Gene

SOURCE GeneReport for Unigene cluster for SERPINA11 Gene Hs.145890

genes like me logo Genes that share expressions with SERPINA11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SERPINA11 Gene

Orthologs for SERPINA11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINA11 35
  • 84.44 (n)
  • 79.15 (a)
SERPINA11 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINA11 35
  • 84.6 (n)
  • 80.57 (a)
SERPINA11 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina11 35
  • 79.3 (n)
  • 75.36 (a)
Serpina11 16
Serpina11 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINA11 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina11 35
  • 76.86 (n)
  • 75.12 (a)
Species with no ortholog for SERPINA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA11 Gene

ENSEMBL:
Gene Tree for SERPINA11 (if available)
TreeFam:
Gene Tree for SERPINA11 (if available)

Paralogs for SERPINA11 Gene

genes like me logo Genes that share paralogs with SERPINA11: view

Variants for SERPINA11 Gene

Sequence variations from dbSNP and Humsavar for SERPINA11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs730383 -- 94,445,540(+) ttaaa(A/G)taGAA intron-variant
rs743208 -- 94,446,180(-) ctcac(A/C)ttttt intron-variant
rs744330 -- 94,445,563(+) AATAT(A/G)ATGAT intron-variant
rs744331 -- 94,445,749(+) ttttt(A/C/T)aattt intron-variant
rs761982 -- 94,452,126(-) GGGTG(C/T)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA11 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832863 CNV Gain 17160897
nsv832864 CNV Loss 17160897
nsv510649 CNV Loss 20534489
nsv1407 CNV Insertion 18451855

Relevant External Links for SERPINA11 Gene

HapMap Linkage Disequilibrium report
SERPINA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA11 Gene

Disorders for SERPINA11 Gene

Relevant External Links for SERPINA11

Genetic Association Database (GAD)
SERPINA11
genes like me logo Genes that share disorders with SERPINA11: view

No data available for UniProtKB/Swiss-Prot for SERPINA11 Gene

Publications for SERPINA11 Gene

  1. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu S.J. … Fournier R.E. (Mamm. Genome 2004) 2 3
  2. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons P.A. … Smith K.G. (N. Engl. J. Med. 2012) 3

Products for SERPINA11 Gene

Sources for SERPINA11 Gene

Back to Top

Content