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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERPINA10 Gene

protein-coding   GIFtS: 53
GCID: GC14M094749

Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,...

(Previous names: serine (or cysteine) proteinase inhibitor, clade A (alpha-1...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase,
Antitrypsin), Member 101 2
     PZI2 3
ZPI2 3 5     PZ-Dependent Protease Inhibitor2 3
Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1
Antiproteinase, Antitrypsin), Member 101 2
     Protein Z-Dependent Protease Inhibitor2
Serpin A102 3     

External Ids:    HGNC: 159961   Entrez Gene: 511562   Ensembl: ENSG000001400937   OMIM: 6052715   UniProtKB: Q9UK553   

Export aliases for SERPINA10 gene to outside databases

Previous GC identifers: GC14M092256 GC14M088566 GC14M092739 GC14M093819 GC14M074929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERPINA10 Gene:
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and
secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z,
calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced
transcript variants have been found for this gene.(provided by RefSeq, May 2010)

GeneCards Summary for SERPINA10 Gene: 
SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10) is a protein-coding gene. Diseases associated with SERPINA10 include central retinal artery occlusion, and thrombosis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPING1.

UniProtKB/Swiss-Prot: ZPI_HUMAN, Q9UK55
Function: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and
phospholipids. Also inhibits factor XIa in the absence of cofactors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERPINA10 gene promoter:
         HOXA9B   HOXA9   Bach2   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERPINA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERPINA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERPINA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

SERPINA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERPINA10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094749:  view genomic region     (about GC identifiers)

Start:
94,749,650 bp from pter      End:
94,759,608 bp from pter
Size:
9,959 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZPI_HUMAN, Q9UK55 (See protein sequence)
Recommended Name: Protein Z-dependent protease inhibitor precursor  
Size: 444 amino acids; 50707 Da
Subunit: Interacts with PROZ
Subcellular location: Secreted
Miscellaneous: Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10
reactions with factor Xa and factor XIa
Sequence caution: Sequence=CAD62339.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for SERPINA10:
3F1S (3D)        3H5C (3D)        4AFX (3D)        4AJU (3D)    
Secondary accessions: A5Z2A5 Q6UWX9 Q86U20

Explore the universe of human proteins at neXtProt for SERPINA10: NX_Q9UK55

Explore proteomics data for SERPINA10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK55

  • SERPINA10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERPINA10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001094077.1  NP_057270.1  

    ENSEMBL proteins: 
     ENSP00000450896   ENSP00000261994   ENSP00000450971   ENSP00000376809  

    Human Recombinant Protein Products for SERPINA10: 
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    Novus Biologicals SERPINA10 Protein
    Novus Biologicals SERPINA10 Lysates
    Sino Biological Recombinant Protein for SERPINA10
    Sino Biological Cell Lysate for SERPINA10 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    SERPINA10 for ontologies           About GeneDecksing



    SERPINA10 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SERPIN: Serine (or cysteine) peptidase inhibitors

    2 InterPro protein domains:
     IPR023796 Serpin_dom
     IPR000215 Serpin_fam

    Graphical View of Domain Structure for InterPro Entry Q9UK55

    ProtoNet protein and cluster: Q9UK55

    1 Blocks protein domain: IPB000215 Serpin

    UniProtKB/Swiss-Prot: ZPI_HUMAN, Q9UK55
    Similarity: Belongs to the serpin family


    SERPINA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZPI_HUMAN, Q9UK55
    Function: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and
    phospholipids. Also inhibits factor XIa in the absence of cofactors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IBA--
    GO:0008201heparin binding IEA--
         
    SERPINA10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERPINA10:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Serpina10):
     cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 

    SERPINA10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SERPINA10: Serpina10tm1Gjb Serpina10tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERPINA10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERPINA10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERPINA10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERPINA10 

    miRNA
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERPINA10
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SERPINA10

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINA10
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                         Customized lentivirus expression plasmids for stable overexpression of SERPINA10 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SERPINA10

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SERPINA10 (Q9UK553 ENSP000002619944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F10P007423, ENSP000003647094I2D: score=1 STRING: ENSP00000364709
    PROZENSP000003646974STRING: ENSP00000364697
    PSMB7ENSP000002594574STRING: ENSP00000259457
    PIAS3ENSP000003767654STRING: ENSP00000376765
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation IEA--
    GO:0010951negative regulation of endopeptidase activity IBA--
    GO:0030162regulation of proteolysis IBA--
    GO:0060046NOT regulation of acrosome reaction IDA11751269

    SERPINA10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SERPINA10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERPINA10 (ZPI)

    1 HMDB Compound for SERPINA10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for SERPINA10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phospholipid 55.2 8 19528533 (1), 18344422 (1), 10460162 (1), 18502758 (1) (see all 6)
    serine 27.9 8 19528533 (1), 18180611 (1)
    calcium 19.7 10 11341501 (1), 11487045 (1), 12911591 (1), 11372680 (1) (see all 7)
    alanine 3.44 1 10460162 (1)
    heparin 3.04 3 16079143 (2), 11049983 (1)

    Search CenterWatch for drugs/clinical trials and news about SERPINA10 / ZPI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERPINA10 gene (2 alternative transcripts): 
    NM_001100607.2  NM_016186.2  

    Unigene Cluster for SERPINA10:

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
    Hs.118620  [show with all ESTs]
    Unigene Representative Sequence: NM_016186
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554723(uc001yct.3) ENST00000261994(uc001ycu.4) ENST00000554173
    ENST00000393096
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERPINA10
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    OriGene qPCR primer pairs and template standards for SERPINA10
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERPINA10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERPINA10

    Additional mRNA sequence: 

    AF181467.1 AK314877.1 AY358597.1 BC022261.1 BX248011.1 

    4 DOTS entries:

    DT.100659432  DT.75113399  DT.100785135  DT.92043046 

    24/33 AceView cDNA sequences (see all 33):

    AI174900 BX496015 BC022261 BX496004 BX248011 AV681541 AF181467 CR606434 
    CB161994 NM_016186 CB164232 BX429460 AA779097 AI183788 BX452425 BX429624 
    AI040537 AI023884 BX452424 AY358597 AI052207 AV649110 AA700364 BX407966 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERPINA10 expression in normal human tissues (normalized intensities)      SERPINA10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAGGGAG
    SERPINA10 Expression
    About this image


    SERPINA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
             visceral organ/metanephros/renal medulla   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ   
     
     Liver (Hepatobiliary System)
             Liver Lobule

    See SERPINA10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERPINA10

    SOURCE GeneReport for Unigene cluster: Hs.118620

    UniProtKB/Swiss-Prot: ZPI_HUMAN, Q9UK55
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERPINA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SERPINA10 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serpina101 , 5 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 more1, 5 77.42(n)1
    72.95(a)1
      12 (52.97 cM)5
    2178471  NM_144834.31  NP_659083.21 
     1036166755 
    chicken
    (Gallus gallus)
    Aves SERPINA101 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, more 60.2(n)
    50.77(a)
      423432  XM_421341.3  XP_421341.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERPINA106
    Uncharacterized protein
    50(a)
    1 ↔ 1
    1(6333329-6339570)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119712 Transcribed sequence with weak similarity to protein more 70.75(n)    CF376175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii serpina10a1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, more 49.17(n)
    30.66(a)
      565064  NM_001045071.2  NP_001038536.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spn53F6
    Spn43Ab6
    (see all 4)
    Serine protease inhibitor 43Ab
    (see all 4)
    21(a)
    20(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2R(13010398-13011742)
    2R(3039170-3041188)


    ENSEMBL Gene Tree for SERPINA10 (if available)
    TreeFam Gene Tree for SERPINA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERPINA10 gene
    SERPING12  SERPINA12  SERPINH12  SERPINA112  SERPINA72  SERPINA122  SERPINA92  SERPINF12  
    SERPINA52  SERPIND12  SERPINA42  SERPINA32  SERPINA62  SERPINF22  
    18/29 SIMAP similar genes for SERPINA10 using alignment to 2 protein entries:     ZPI_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D06190    SERPINA6    SERPINA12    SERPINA3    SERPINA9    SERPINI2
    SERPINA5    SERPINB1    SERPINI1    DKFZp686O07189    SERPINA1    SERPINA2P
    SERPINB11    SERPINB12    SERPINB2    SERPINA7    SERPINB6    SERPINB7

    SERPINA10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/374 SNPs in SERPINA10 are shown (see all 374)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483855971,2
    C,Funtested175745293(+) ATGAAG/AGCAAA 4 /A syn11Minor allele frequency- A:0.00NA 4506
    rs617544871,2
    C,Fother175743503(+) CTGAGC/TCATGT 4 * W stg12Minor allele frequency- T:0.00NA EU 5873
    VAR_0388354
    ----see VAR_0388352 Q P mis40--------
    rs1465038531,2
    --75738081(+) GAATAC/TGGACC 2 -- ds50010--------
    rs557036741,2
    C,F--75738261(-) ATCTAT/CTACGG 2 -- ds50014Minor allele frequency- C:0.05NS WA 210
    rs1893126471,2
    C--75738323(+) ATGACC/TCAAGG 2 -- ds50010--------
    rs1810482351,2
    --75738391(+) CAACTG/TTTTAA 2 -- ds50010--------
    rs740759221,2
    C,F--75738561(+) ATCCAG/TGGTTT 2 -- ut311Minor allele frequency- T:0.50WA 2
    rs114411,2
    C,F--75738696(+) TGCATT/CGTCCT 2 -- ut3117Minor allele frequency- C:0.44MN NA NS WA CSA EA 980
    rs1138341031,2
    C,F--75738767(+) TCCTCG/ACCCAT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SERPINA10 (94749650 - 94759608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SERPINA10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832862CNV Gain17160897
    nsv470659CNV Gain18288195


    Human Gene Mutation Database (HGMD): SERPINA10
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605271    OMIM disorders: --

    15 diseases for SERPINA10:    About MalaCards
    central retinal artery occlusion    thrombosis    retinal artery occlusion    venous thromboembolism
    protein c deficiency    thrombophilia    neuroendocrine carcinoma    thromboembolism
    retinitis    kidney disease    myocardial infarction    colon cancer
    endotheliitis    breast cancer    lung cancer


    SERPINA10 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SERPINA10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    venous thrombosis 38.5 5 15735788 (2), 15461625 (1)
    thrombosis 35.3 4 11487045 (1), 18344422 (1), 16527896 (1), 15461625 (1)
    thrombophilia 33.6 4 15461625 (2), 15735788 (1)

    Genetic Association Database (GAD): SERPINA10
    Human Genome Epidemiology (HuGE) Navigator: SERPINA10 (5 documents)

    Export disorders for SERPINA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERPINA10 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with SERPINA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein Z-dependent protease inhibitor is a serpin. (PubMed id 10460162)1, 2, 3, 9 Han X.... Broze G.J. Jr. (1999)
    2. Isolation of a protein Z-dependent plasma protease inhibitor. (PubMed id 9689066)1, 2, 3, 9 Han X.... Broze G.J. Jr. (1998)
    3. Characterization of the protein Z-dependent protease inhibitor. (PubMed id 11049983)1, 2, 9 Han X.... Broze G.J. Jr. (2000)
    4. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis. (PubMed id 16527896)1, 4, 9 Corral J....Vicente V. (2006)
    5. Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis. (PubMed id 18710385)1, 4, 9 Dentali F....Ageno W. (2008)
    6. Characterization of the heparin-binding site of the pr otein z-dependent protease inhibitor. (PubMed id 22540147)1, 2 Yang L....Rezaie A.R. (2012)
    7. Basis for the specificity and activation of the serpi n protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-as sociated factor Xa. (PubMed id 20427285)1, 2 Huang X....Gettins P.G. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51156 HGNC: 15996 AceView: SERPINA10 Ensembl:ENSG00000140093 euGenes: HUgn51156
    ECgene: SERPINA10 H-InvDB: SERPINA10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERPINA10 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/serpina10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERPINA10 gene:
    Search GeneIP for patents involving SERPINA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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