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Aliases for SERPINA10 Gene

Aliases for SERPINA10 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • ZPI 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • PZ-Dependent Protease Inhibitor 3 4
  • Serpin A10 3 4
  • PZI 3 4
  • Protein Z-Dependent Protease Inhibitor 3

External Ids for SERPINA10 Gene

Summaries for SERPINA10 Gene

Entrez Gene Summary for SERPINA10 Gene

  • The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for SERPINA10 Gene

SERPINA10 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10) is a Protein Coding gene. GO annotations related to this gene include heparin binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA12.

UniProtKB/Swiss-Prot for SERPINA10 Gene

  • Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA10 Gene

Genomics for SERPINA10 Gene

Genomic Location for SERPINA10 Gene

Start:
94,280,455 bp from pter
End:
94,293,271 bp from pter
Size:
12,817 bases
Orientation:
Minus strand

Genomic View for SERPINA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA10 Gene

Regulatory Elements for SERPINA10 Gene

Proteins for SERPINA10 Gene

  • Protein details for SERPINA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK55-ZPI_HUMAN
    Recommended name:
    Protein Z-dependent protease inhibitor
    Protein Accession:
    Q9UK55
    Secondary Accessions:
    • A5Z2A5
    • Q6UWX9
    • Q86U20

    Protein attributes for SERPINA10 Gene

    Size:
    444 amino acids
    Molecular mass:
    50707 Da
    Quaternary structure:
    • Interacts with PROZ.
    Miscellaneous:
    • Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa
    SequenceCaution:
    • Sequence=CAD62339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINA10 Gene

neXtProt entry for SERPINA10 Gene

Proteomics data for SERPINA10 Gene at MOPED

Post-translational modifications for SERPINA10 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINA10 Gene

No data available for DME Specific Peptides for SERPINA10 Gene

Domains for SERPINA10 Gene

Gene Families for SERPINA10 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA10 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ZPI_HUMAN
Family:
  • Belongs to the serpin family.:
    • Q9UK55
genes like me logo Genes that share domains with SERPINA10: view

Function for SERPINA10 Gene

Molecular function for SERPINA10 Gene

UniProtKB/Swiss-Prot Function: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

Gene Ontology (GO) - Molecular Function for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with SERPINA10: view
genes like me logo Genes that share phenotypes with SERPINA10: view

Animal Models for SERPINA10 Gene

MGI Knock Outs for SERPINA10:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA10 Gene

Localization for SERPINA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA10 Gene COMPARTMENTS Subcellular localization image for SERPINA10 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SERPINA10: view

Pathways for SERPINA10 Gene

SuperPathways for SERPINA10 Gene

No Data Available

Interacting Proteins for SERPINA10 Gene

Gene Ontology (GO) - Biological Process for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
GO:0060046 NOT regulation of acrosome reaction IDA 11751269
genes like me logo Genes that share ontologies with SERPINA10: view

No data available for Pathways by source for SERPINA10 Gene

Compounds for SERPINA10 Gene

(1) HMDB Compounds for SERPINA10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) Novoseek inferred chemical compound relationships for SERPINA10 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 55.2 6
serine 27.9 2
calcium 19.7 7
alanine 3.44 1
heparin 3.04 3
genes like me logo Genes that share compounds with SERPINA10: view

Transcripts for SERPINA10 Gene

Unigene Clusters for SERPINA10 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA10 Gene

No ASD Table

Relevant External Links for SERPINA10 Gene

GeneLoc Exon Structure for
SERPINA10
ECgene alternative splicing isoforms for
SERPINA10

Expression for SERPINA10 Gene

mRNA expression in normal human tissues for SERPINA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA10 Gene

This gene is overexpressed in Liver (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINA10 Gene

SOURCE GeneReport for Unigene cluster for SERPINA10 Gene Hs.118620

mRNA Expression by UniProt/SwissProt for SERPINA10 Gene

Q9UK55-ZPI_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with SERPINA10: view

Orthologs for SERPINA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA10 36
  • 98.95 (n)
  • 98.65 (a)
SERPINA10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINA10 36
  • 79.43 (n)
  • 69.72 (a)
SERPINA10 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Serpina10 36
  • 77.52 (n)
  • 73.3 (a)
Serpina10 16
Serpina10 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINA10 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA10 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909524 36
  • 77.94 (n)
  • 73.52 (a)
chicken
(Gallus gallus)
Aves SERPINA10 36
  • 61.79 (n)
  • 52.3 (a)
SERPINA10 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINA10 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpina10 36
  • 56.63 (n)
  • 48.92 (a)
Str.11971 36
zebrafish
(Danio rerio)
Actinopterygii serpina10a 36
  • 49.63 (n)
  • 31.56 (a)
serpina10a 37
  • 28 (a)
OneToOne
Species with no ortholog for SERPINA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA10 Gene

ENSEMBL:
Gene Tree for SERPINA10 (if available)
TreeFam:
Gene Tree for SERPINA10 (if available)

Paralogs for SERPINA10 Gene

genes like me logo Genes that share paralogs with SERPINA10: view

Variants for SERPINA10 Gene

Sequence variations from dbSNP and Humsavar for SERPINA10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11441 -- 94,283,499(+) TGCAT(C/T)GTCCT utr-variant-3-prime
rs12793 -- 94,283,635(+) CTTGC(A/G)TTCAA utr-variant-3-prime
rs941590 - 94,290,457(-) TCCCA(A/G)GGAGG reference, missense
rs941591 - 94,290,413(-) AGGCC(A/G)GTGAG reference, missense
rs1950641 -- 94,283,955(-) GGACA(C/T)GCATA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINA10 Gene

Variant ID Type Subtype PubMed ID
nsv470659 CNV Gain 18288195
nsv832862 CNV Gain 17160897

Relevant External Links for SERPINA10 Gene

HapMap Linkage Disequilibrium report
SERPINA10
Human Gene Mutation Database (HGMD)
SERPINA10

Disorders for SERPINA10 Gene

(3) Novoseek inferred disease relationships for SERPINA10 Gene

Disease -log(P) Hits PubMed IDs
venous thrombosis 38.5 3
thrombosis 35.3 4
thrombophilia 33.6 3

Relevant External Links for SERPINA10

Genetic Association Database (GAD)
SERPINA10
Human Genome Epidemiology (HuGE) Navigator
SERPINA10
genes like me logo Genes that share disorders with SERPINA10: view

No data available for UniProtKB/Swiss-Prot for SERPINA10 Gene

Publications for SERPINA10 Gene

  1. Isolation of a protein Z-dependent plasma protease inhibitor. (PMID: 9689066) Han X. … Broze G.J. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. The protein Z-dependent protease inhibitor is a serpin. (PMID: 10460162) Han X. … Broze G.J. Jr. (Biochemistry 1999) 2 3 4 23
  3. Characterization of the protein Z-dependent protease inhibitor. (PMID: 11049983) Han X. … Broze G.J. Jr. (Blood 2000) 3 4 23
  4. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis. (PMID: 16527896) Corral J. … Vicente V. (Blood 2006) 3 23 49
  5. Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis. (PMID: 18710385) Dentali F. … Ageno W. (Br. J. Haematol. 2008) 3 23 49

Products for SERPINA10 Gene

Sources for SERPINA10 Gene

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