Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINA10 Gene

Aliases for SERPINA10 Gene

  • Serpin Family A Member 10 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • PZ-Dependent Protease Inhibitor 3 4
  • Serpin A10 3 4
  • PZI 3 4
  • ZPI 3 4
  • Protein Z-Dependent Protease Inhibitor 3

External Ids for SERPINA10 Gene

Previous GeneCards Identifiers for SERPINA10 Gene

  • GC14M092256
  • GC14M088566
  • GC14M092739
  • GC14M093819
  • GC14M094749
  • GC14M074929

Summaries for SERPINA10 Gene

Entrez Gene Summary for SERPINA10 Gene

  • The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for SERPINA10 Gene

SERPINA10 (Serpin Family A Member 10) is a Protein Coding gene. Diseases associated with SERPINA10 include Protein Z Deficiency and Thrombosis. Gene Ontology (GO) annotations related to this gene include heparin binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA1.

UniProtKB/Swiss-Prot for SERPINA10 Gene

  • Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

Additional gene information for SERPINA10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA10 Gene

Genomics for SERPINA10 Gene

GeneHancer (GH) Regulatory Elements for SERPINA10 Gene

Promoters and enhancers for SERPINA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I094292 Promoter/Enhancer 1.4 EPDnew ENCODE 550.8 +0.1 83 1.1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 RXRA MIER2 REST SERPINA10 ENSG00000256357 GC14M094218
GH14I094597 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38 -306.9 -306933 6.1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP5 SERPINA10 SERPINA3 SERPINA1 SERPINA5 SCARNA13 SNHG10 DICER1 SERPINA6 SERPINA11 SERPINA4
GH14I094593 Enhancer 1.2 FANTOM5 ENCODE 16.7 -300.8 -300796 1.1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 SERPINA5 SERPINA1 SERPINA6 SERPINA11 SERPINA10 SERPINA3 SERPINA4 ENSG00000273259
GH14I094281 Enhancer 0.3 FANTOM5 33.5 +11.2 11244 0.3 SERPINA6 SERPINA10 SERPINA3 SERPINA11 SERPINA1 SERPINA4 ENSG00000256357 PPP4R4 SERPINA5 GC14M094218
GH14I094322 Promoter/Enhancer 1.4 EPDnew ENCODE 0.3 -29.7 -29675 1.6 FOXA2 ARID4B DMAP1 ZNF48 ETS1 YY1 GLIS2 RXRA SP5 NFYC SERPINA6 ENSG00000256357 SERPINA1 SERPINA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERPINA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERPINA10 gene promoter:

Genomic Locations for SERPINA10 Gene

Genomic Locations for SERPINA10 Gene
chr14:94,280,455-94,293,271
(GRCh38/hg38)
Size:
12,817 bases
Orientation:
Minus strand
chr14:94,749,650-94,759,608
(GRCh37/hg19)

Genomic View for SERPINA10 Gene

Genes around SERPINA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA10 Gene

Proteins for SERPINA10 Gene

  • Protein details for SERPINA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK55-ZPI_HUMAN
    Recommended name:
    Protein Z-dependent protease inhibitor
    Protein Accession:
    Q9UK55
    Secondary Accessions:
    • A5Z2A5
    • Q6UWX9
    • Q86U20

    Protein attributes for SERPINA10 Gene

    Size:
    444 amino acids
    Molecular mass:
    50707 Da
    Quaternary structure:
    • Interacts with PROZ.
    Miscellaneous:
    • Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
    SequenceCaution:
    • Sequence=CAD62339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINA10 Gene

neXtProt entry for SERPINA10 Gene

Post-translational modifications for SERPINA10 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at isoforms=36, posLast=180180, posLast=197197, and isoforms=295

Other Protein References for SERPINA10 Gene

Antibody Products

  • R&D Systems Antibodies for SERPINA10 (Serpin A10/ZPI)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SERPINA10

No data available for DME Specific Peptides for SERPINA10 Gene

Domains & Families for SERPINA10 Gene

Gene Families for SERPINA10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SERPINA10 Gene

Suggested Antigen Peptide Sequences for SERPINA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK55

UniProtKB/Swiss-Prot:

ZPI_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA10: view

Function for SERPINA10 Gene

Molecular function for SERPINA10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

Phenotypes From GWAS Catalog for SERPINA10 Gene

Gene Ontology (GO) - Molecular Function for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0008201 heparin binding IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SERPINA10: view
genes like me logo Genes that share phenotypes with SERPINA10: view

Animal Models for SERPINA10 Gene

MGI Knock Outs for SERPINA10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA10 Gene

Localization for SERPINA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERPINA10 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with SERPINA10: view

Pathways & Interactions for SERPINA10 Gene

SuperPathways for SERPINA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
GO:0008218 bioluminescence IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SERPINA10: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA10 Gene

Drugs & Compounds for SERPINA10 Gene

(4) Drugs for SERPINA10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for SERPINA10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINA10: view

Transcripts for SERPINA10 Gene

Unigene Clusters for SERPINA10 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA10 Gene

No ASD Table

Relevant External Links for SERPINA10 Gene

GeneLoc Exon Structure for
SERPINA10
ECgene alternative splicing isoforms for
SERPINA10

Expression for SERPINA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERPINA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA10 Gene

This gene is overexpressed in Liver (x52.2).

Protein differential expression in normal tissues from HIPED for SERPINA10 Gene

This gene is overexpressed in Serum (41.3) and Plasma (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINA10 Gene



NURSA nuclear receptor signaling pathways regulating expression of SERPINA10 Gene:

SERPINA10

SOURCE GeneReport for Unigene cluster for SERPINA10 Gene:

Hs.118620

mRNA Expression by UniProt/SwissProt for SERPINA10 Gene:

Q9UK55-ZPI_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for SERPINA10 Gene

  • Liver(4.6)
  • Bone marrow(4)
  • Blood(2)
genes like me logo Genes that share expression patterns with SERPINA10: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERPINA10 Gene

Orthologs for SERPINA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA10 33 34
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia SERPINA10 33 34
  • 79.43 (n)
rat
(Rattus norvegicus)
Mammalia Serpina10 33
  • 77.94 (n)
mouse
(Mus musculus)
Mammalia Serpina10 33 16 34
  • 77.52 (n)
oppossum
(Monodelphis domestica)
Mammalia SERPINA10 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA10 34
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SERPINA10 33 34
  • 61.79 (n)
lizard
(Anolis carolinensis)
Reptilia SERPINA10 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpina10 33
  • 56.63 (n)
Str.11971 33
zebrafish
(Danio rerio)
Actinopterygii serpina10a 33 34
  • 49.63 (n)
Species where no ortholog for SERPINA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA10 Gene

ENSEMBL:
Gene Tree for SERPINA10 (if available)
TreeFam:
Gene Tree for SERPINA10 (if available)

Paralogs for SERPINA10 Gene

Variants for SERPINA10 Gene

Sequence variations from dbSNP and Humsavar for SERPINA10 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs61754487 uncertain-significance, Venous thrombosis, susceptibility to 94,288,306(-) C/T coding_sequence_variant, stop_gained
rs1000089446 -- 94,294,548(-) A/C upstream_transcript_variant
rs1000652686 -- 94,285,517(-) ACACACACACA/ACACACACA intron_variant
rs1000918236 -- 94,289,133(-) T/G intron_variant
rs1001248188 -- 94,288,060(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA10 Gene

Variant ID Type Subtype PubMed ID
esv3635377 CNV gain 21293372
nsv470659 CNV gain 18288195
nsv832862 CNV gain 17160897

Variation tolerance for SERPINA10 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERPINA10 Gene

Human Gene Mutation Database (HGMD)
SERPINA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERPINA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA10 Gene

Disorders for SERPINA10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SERPINA10 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
protein z deficiency
  • protein z
thrombosis
  • thrombosis of blood vessel
central retinal artery occlusion
thrombophilia
  • hypercoagulability state
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERPINA10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SERPINA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINA10 Gene

Publications for SERPINA10 Gene

  1. The protein Z-dependent protease inhibitor is a serpin. (PMID: 10460162) Han X … Broze GJ (Biochemistry 1999) 2 3 4 22 58
  2. Isolation of a protein Z-dependent plasma protease inhibitor. (PMID: 9689066) Han X … Broze GJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  3. Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis. (PMID: 18710385) Dentali F … Ageno W (British journal of haematology 2008) 3 22 44 58
  4. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis. (PMID: 16527896) Corral J … Vicente V (Blood 2006) 3 22 44 58
  5. Characterization of the protein Z-dependent protease inhibitor. (PMID: 11049983) Han X … Broze GJ (Blood 2000) 3 4 22 58

Products for SERPINA10 Gene

Sources for SERPINA10 Gene

Content
Loading form....