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Aliases for SERPINA10 Gene

Aliases for SERPINA10 Gene

  • Serpin Family A Member 10 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3 5
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • PZ-Dependent Protease Inhibitor 3 4
  • Serpin A10 3 4
  • PZI 3 4
  • ZPI 3 4

External Ids for SERPINA10 Gene

Previous GeneCards Identifiers for SERPINA10 Gene

  • GC14M092256
  • GC14M088566
  • GC14M092739
  • GC14M093819
  • GC14M094749
  • GC14M074929

Summaries for SERPINA10 Gene

Entrez Gene Summary for SERPINA10 Gene

  • The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for SERPINA10 Gene

SERPINA10 (Serpin Family A Member 10) is a Protein Coding gene. Diseases associated with SERPINA10 include thrombophilia due to thrombin defect and central retinal artery occlusion. GO annotations related to this gene include heparin binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA11.

UniProtKB/Swiss-Prot for SERPINA10 Gene

  • Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA10 Gene

Genomics for SERPINA10 Gene

Regulatory Elements for SERPINA10 Gene

Promoters for SERPINA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERPINA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERPINA10 Gene

Chromosome:
14
Start:
94,280,455 bp from pter
End:
94,293,271 bp from pter
Size:
12,817 bases
Orientation:
Minus strand

Genomic View for SERPINA10 Gene

Genes around SERPINA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA10 Gene

Proteins for SERPINA10 Gene

  • Protein details for SERPINA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK55-ZPI_HUMAN
    Recommended name:
    Protein Z-dependent protease inhibitor
    Protein Accession:
    Q9UK55
    Secondary Accessions:
    • A5Z2A5
    • Q6UWX9
    • Q86U20

    Protein attributes for SERPINA10 Gene

    Size:
    444 amino acids
    Molecular mass:
    50707 Da
    Quaternary structure:
    • Interacts with PROZ.
    Miscellaneous:
    • Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
    SequenceCaution:
    • Sequence=CAD62339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINA10 Gene

neXtProt entry for SERPINA10 Gene

Proteomics data for SERPINA10 Gene at MOPED

Post-translational modifications for SERPINA10 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Asn 36, Asn 180, Asn 197, and Asn 295
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINA10 Gene

Antibody Products

No data available for DME Specific Peptides for SERPINA10 Gene

Domains & Families for SERPINA10 Gene

Gene Families for SERPINA10 Gene

Protein Domains for SERPINA10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK55

UniProtKB/Swiss-Prot:

ZPI_HUMAN :
  • Belongs to the serpin family.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA10: view

Function for SERPINA10 Gene

Molecular function for SERPINA10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
genes like me logo Genes that share phenotypes with SERPINA10: view

Animal Models for SERPINA10 Gene

MGI Knock Outs for SERPINA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINA10

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA10 Gene

Localization for SERPINA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA10 Gene COMPARTMENTS Subcellular localization image for SERPINA10 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 2
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for SERPINA10 Gene

Pathways & Interactions for SERPINA10 Gene

SuperPathways for SERPINA10 Gene

No Data Available

Interacting Proteins for SERPINA10 Gene

Gene Ontology (GO) - Biological Process for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 10460162
genes like me logo Genes that share ontologies with SERPINA10: view

No data available for Pathways by source and SIGNOR curated interactions for SERPINA10 Gene

Drugs & Compounds for SERPINA10 Gene

(4) Drugs for SERPINA10 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SERPINA10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINA10: view

Transcripts for SERPINA10 Gene

Unigene Clusters for SERPINA10 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA10 Gene

No ASD Table

Relevant External Links for SERPINA10 Gene

GeneLoc Exon Structure for
SERPINA10
ECgene alternative splicing isoforms for
SERPINA10

Expression for SERPINA10 Gene

mRNA expression in normal human tissues for SERPINA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA10 Gene

This gene is overexpressed in Liver (x52.2).

Protein differential expression in normal tissues from HIPED for SERPINA10 Gene

This gene is overexpressed in Serum (41.3) and Plasma (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINA10 Gene



SOURCE GeneReport for Unigene cluster for SERPINA10 Gene Hs.118620

mRNA Expression by UniProt/SwissProt for SERPINA10 Gene

Q9UK55-ZPI_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with SERPINA10: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SERPINA10 Gene

Orthologs for SERPINA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINA10 35
  • 79.43 (n)
  • 69.72 (a)
SERPINA10 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina10 35
  • 77.52 (n)
  • 73.3 (a)
Serpina10 16
Serpina10 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINA10 35
  • 98.95 (n)
  • 98.65 (a)
SERPINA10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909524 35
  • 77.94 (n)
  • 73.52 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 22 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SERPINA10 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINA10 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERPINA10 35
  • 61.79 (n)
  • 52.3 (a)
SERPINA10 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINA10 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serpina10 35
  • 56.63 (n)
  • 48.92 (a)
Str.11971 35
zebrafish
(Danio rerio)
Actinopterygii serpina10a 35
  • 49.63 (n)
  • 31.56 (a)
serpina10a 36
  • 28 (a)
OneToOne
Species with no ortholog for SERPINA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA10 Gene

ENSEMBL:
Gene Tree for SERPINA10 (if available)
TreeFam:
Gene Tree for SERPINA10 (if available)

Paralogs for SERPINA10 Gene

genes like me logo Genes that share paralogs with SERPINA10: view

Variants for SERPINA10 Gene

Sequence variations from dbSNP and Humsavar for SERPINA10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs941590 - 94,290,457(-) TCCCA(A/G)GGAGG reference, missense
rs941591 - 94,290,413(-) AGGCC(A/C/G)GTGAG reference, missense
rs2232700 - 94,290,113(-) GCCTC(A/T)CACAG reference, missense
rs56137907 - 94,290,179(-) AGCCC(A/G)GGCTC reference, missense
rs2232708 - 94,288,467(-) TGTAC(A/G)GTGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SERPINA10 Gene

Variant ID Type Subtype PubMed ID
nsv470659 CNV Gain 18288195
nsv832862 CNV Gain 17160897

Variation tolerance for SERPINA10 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINA10 Gene

HapMap Linkage Disequilibrium report
SERPINA10
Human Gene Mutation Database (HGMD)
SERPINA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA10 Gene

Disorders for SERPINA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SERPINA10 Gene - From: GeneTests, DISEASES, and Novoseek

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINA10

Genetic Association Database (GAD)
SERPINA10
Human Genome Epidemiology (HuGE) Navigator
SERPINA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINA10
genes like me logo Genes that share disorders with SERPINA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINA10 Gene

Publications for SERPINA10 Gene

  1. The protein Z-dependent protease inhibitor is a serpin. (PMID: 10460162) Han X. … Broze G.J. Jr. (Biochemistry 1999) 2 3 4 23 67
  2. Isolation of a protein Z-dependent plasma protease inhibitor. (PMID: 9689066) Han X. … Broze G.J. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 23
  3. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  4. A computational modeling and molecular dynamics study of the Michaelis complex of human protein Z-dependent protease inhibitor (ZPI) and factor Xa (FXa). (PMID: 19172319) Chandrasekaran V. … Pedersen L.G. (J Mol Model 2009) 3 23
  5. Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis. (PMID: 18710385) Dentali F. … Ageno W. (Br. J. Haematol. 2008) 3 23

Products for SERPINA10 Gene

Sources for SERPINA10 Gene

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