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Aliases for SERPINA10 Gene

Aliases for SERPINA10 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • ZPI 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 2 3
  • PZ-Dependent Protease Inhibitor 3 4
  • Serpin A10 3 4
  • PZI 3 4
  • Protein Z-Dependent Protease Inhibitor 3

External Ids for SERPINA10 Gene

Previous GeneCards Identifiers for SERPINA10 Gene

  • GC14M092256
  • GC14M088566
  • GC14M092739
  • GC14M093819
  • GC14M094749
  • GC14M074929

Summaries for SERPINA10 Gene

Entrez Gene Summary for SERPINA10 Gene

  • The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for SERPINA10 Gene

SERPINA10 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10) is a Protein Coding gene. GO annotations related to this gene include heparin binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA12.

UniProtKB/Swiss-Prot for SERPINA10 Gene

  • Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA10 Gene

Genomics for SERPINA10 Gene

Regulatory Elements for SERPINA10 Gene

Genomic Location for SERPINA10 Gene

Start:
94,280,455 bp from pter
End:
94,293,271 bp from pter
Size:
12,817 bases
Orientation:
Minus strand

Genomic View for SERPINA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA10 Gene

Proteins for SERPINA10 Gene

  • Protein details for SERPINA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK55-ZPI_HUMAN
    Recommended name:
    Protein Z-dependent protease inhibitor
    Protein Accession:
    Q9UK55
    Secondary Accessions:
    • A5Z2A5
    • Q6UWX9
    • Q86U20

    Protein attributes for SERPINA10 Gene

    Size:
    444 amino acids
    Molecular mass:
    50707 Da
    Quaternary structure:
    • Interacts with PROZ.
    Miscellaneous:
    • Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa
    SequenceCaution:
    • Sequence=CAD62339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINA10 Gene

neXtProt entry for SERPINA10 Gene

Proteomics data for SERPINA10 Gene at MOPED

Post-translational modifications for SERPINA10 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINA10 Gene

Antibody Products

No data available for DME Specific Peptides for SERPINA10 Gene

Domains for SERPINA10 Gene

Gene Families for SERPINA10 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK55

UniProtKB/Swiss-Prot:

ZPI_HUMAN :
  • Q9UK55
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA10: view

Function for SERPINA10 Gene

Molecular function for SERPINA10 Gene

UniProtKB/Swiss-Prot Function: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.

Gene Ontology (GO) - Molecular Function for SERPINA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with SERPINA10: view
genes like me logo Genes that share phenotypes with SERPINA10: view

Animal Models for SERPINA10 Gene

MGI Knock Outs for SERPINA10:

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINA10
    • Block miRNA regulation of SERPINA10 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA10

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA10 Gene

    Localization for SERPINA10 Gene

    Subcellular locations from UniProtKB/Swiss-Prot for SERPINA10 Gene

    Secreted.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for SERPINA10 Gene COMPARTMENTS Subcellular localization image for SERPINA10 gene
    Compartment Confidence
    extracellular 5
    endoplasmic reticulum 2
    cytosol 1
    golgi apparatus 1
    nucleus 1

    Gene Ontology (GO) - Cellular Components for SERPINA10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005615 extracellular space IBA --
    GO:0070062 extracellular exosome IDA 23533145
    genes like me logo Genes that share ontologies with SERPINA10: view

    Pathways for SERPINA10 Gene

    SuperPathways for SERPINA10 Gene

    No Data Available

    Interacting Proteins for SERPINA10 Gene

    Gene Ontology (GO) - Biological Process for SERPINA10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0007596 blood coagulation IEA --
    GO:0010951 negative regulation of endopeptidase activity IBA --
    GO:0030162 regulation of proteolysis --
    GO:0060046 NOT regulation of acrosome reaction IDA 11751269
    genes like me logo Genes that share ontologies with SERPINA10: view

    No data available for Pathways by source for SERPINA10 Gene

    Compounds for SERPINA10 Gene

    (1) HMDB Compounds for SERPINA10 Gene

    Compound Synonyms Cas Number PubMed IDs
    Calcium
    • Ca
    7440-70-2

    (5) Novoseek inferred chemical compound relationships for SERPINA10 Gene

    Compound -log(P) Hits PubMed IDs
    phospholipid 55.2 6
    serine 27.9 2
    calcium 19.7 7
    alanine 3.44 1
    heparin 3.04 3
    genes like me logo Genes that share compounds with SERPINA10: view

    Transcripts for SERPINA10 Gene

    Unigene Clusters for SERPINA10 Gene

    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate SERPINA10
      • Block miRNA regulation of SERPINA10 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA10

      Primer Products

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA10 Gene

      No ASD Table

      Relevant External Links for SERPINA10 Gene

      GeneLoc Exon Structure for
      SERPINA10
      ECgene alternative splicing isoforms for
      SERPINA10

      Expression for SERPINA10 Gene

      mRNA expression in normal human tissues for SERPINA10 Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for SERPINA10 Gene

      This gene is overexpressed in Liver (52.2).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINA10 Gene

      SOURCE GeneReport for Unigene cluster for SERPINA10 Gene Hs.118620

      mRNA Expression by UniProt/SwissProt for SERPINA10 Gene

      Q9UK55-ZPI_HUMAN
      Tissue specificity: Expressed by the liver and secreted in plasma
      genes like me logo Genes that share expressions with SERPINA10: view

      In Situ Assay Products

      Orthologs for SERPINA10 Gene

      This gene was present in the common ancestor of chordates.

      Orthologs for SERPINA10 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia SERPINA10 35
      • 98.95 (n)
      • 98.65 (a)
      SERPINA10 36
      • 99 (a)
      OneToOne
      cow
      (Bos Taurus)
      Mammalia SERPINA10 35
      • 79.43 (n)
      • 69.72 (a)
      SERPINA10 36
      • 68 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia -- 36
      • 22 (a)
      ManyToMany
      mouse
      (Mus musculus)
      Mammalia Serpina10 35
      • 77.52 (n)
      • 73.3 (a)
      Serpina10 16
      Serpina10 36
      • 71 (a)
      OneToOne
      oppossum
      (Monodelphis domestica)
      Mammalia SERPINA10 36
      • 60 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia SERPINA10 36
      • 47 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia LOC100909524 35
      • 77.94 (n)
      • 73.52 (a)
      chicken
      (Gallus gallus)
      Aves SERPINA10 35
      • 61.79 (n)
      • 52.3 (a)
      SERPINA10 36
      • 46 (a)
      OneToOne
      lizard
      (Anolis carolinensis)
      Reptilia SERPINA10 36
      • 50 (a)
      OneToOne
      tropical clawed frog
      (Silurana tropicalis)
      Amphibia serpina10 35
      • 56.63 (n)
      • 48.92 (a)
      Str.11971 35
      zebrafish
      (Danio rerio)
      Actinopterygii serpina10a 35
      • 49.63 (n)
      • 31.56 (a)
      serpina10a 36
      • 28 (a)
      OneToOne
      Species with no ortholog for SERPINA10:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for SERPINA10 Gene

      ENSEMBL:
      Gene Tree for SERPINA10 (if available)
      TreeFam:
      Gene Tree for SERPINA10 (if available)

      Paralogs for SERPINA10 Gene

      genes like me logo Genes that share paralogs with SERPINA10: view

      Variants for SERPINA10 Gene

      Sequence variations from dbSNP and Humsavar for SERPINA10 Gene

      SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
      rs11441 -- 94,283,499(+) TGCAT(C/T)GTCCT utr-variant-3-prime
      rs12793 -- 94,283,635(+) CTTGC(A/G)TTCAA utr-variant-3-prime
      rs941590 - 94,290,457(-) TCCCA(A/G)GGAGG reference, missense
      rs941591 - 94,290,413(-) AGGCC(A/G)GTGAG reference, missense
      rs1950641 -- 94,283,955(-) GGACA(C/T)GCATA utr-variant-3-prime

      Structural Variations from Database of Genomic Variants (DGV) for SERPINA10 Gene

      Variant ID Type Subtype PubMed ID
      nsv470659 CNV Gain 18288195
      nsv832862 CNV Gain 17160897

      Relevant External Links for SERPINA10 Gene

      HapMap Linkage Disequilibrium report
      SERPINA10
      Human Gene Mutation Database (HGMD)
      SERPINA10

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA10 Gene

      Disorders for SERPINA10 Gene

      (3) Novoseek inferred disease relationships for SERPINA10 Gene

      Disease -log(P) Hits PubMed IDs
      venous thrombosis 38.5 3
      thrombosis 35.3 4
      thrombophilia 33.6 3

      Relevant External Links for SERPINA10

      Genetic Association Database (GAD)
      SERPINA10
      Human Genome Epidemiology (HuGE) Navigator
      SERPINA10
      genes like me logo Genes that share disorders with SERPINA10: view

      No data available for UniProtKB/Swiss-Prot for SERPINA10 Gene

      Publications for SERPINA10 Gene

      1. Isolation of a protein Z-dependent plasma protease inhibitor. (PMID: 9689066) Han X. … Broze G.J. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
      2. The protein Z-dependent protease inhibitor is a serpin. (PMID: 10460162) Han X. … Broze G.J. Jr. (Biochemistry 1999) 2 3 4 23
      3. Characterization of the protein Z-dependent protease inhibitor. (PMID: 11049983) Han X. … Broze G.J. Jr. (Blood 2000) 3 4 23
      4. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis. (PMID: 16527896) Corral J. … Vicente V. (Blood 2006) 3 23 48
      5. Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis. (PMID: 18710385) Dentali F. … Ageno W. (Br. J. Haematol. 2008) 3 23 48

      Products for SERPINA10 Gene

      Sources for SERPINA10 Gene

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