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Aliases for SERP2 Gene

Aliases for SERP2 Gene

  • Stress-Associated Endoplasmic Reticulum Protein Family Member 2 2 3 5
  • Ribosome-Associated Membrane Protein RAMP4-2 3 4
  • C13orf21 3 4
  • Chromosome 13 Open Reading Frame 21 2
  • BA269C23.1 3

External Ids for SERP2 Gene

Previous HGNC Symbols for SERP2 Gene

  • C13orf21

Previous GeneCards Identifiers for SERP2 Gene

  • GC13P043845
  • GC13P044947
  • GC13P025749

Summaries for SERP2 Gene

GeneCards Summary for SERP2 Gene

SERP2 (Stress-Associated Endoplasmic Reticulum Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is SERP1.

UniProtKB/Swiss-Prot for SERP2 Gene

  • May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERP2 Gene

Genomics for SERP2 Gene

Regulatory Elements for SERP2 Gene

Enhancers for SERP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERP2 on UCSC Golden Path with GeneCards custom track

Promoters for SERP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERP2 Gene

Chromosome:
13
Start:
44,373,665 bp from pter
End:
44,397,714 bp from pter
Size:
24,050 bases
Orientation:
Plus strand

Genomic View for SERP2 Gene

Genes around SERP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP2 Gene

Proteins for SERP2 Gene

  • Protein details for SERP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6R1-SERP2_HUMAN
    Recommended name:
    Stress-associated endoplasmic reticulum protein 2
    Protein Accession:
    Q8N6R1

    Protein attributes for SERP2 Gene

    Size:
    65 amino acids
    Molecular mass:
    7431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERP2 Gene

Proteomics data for SERP2 Gene at MOPED

Post-translational modifications for SERP2 Gene

No Post-translational modifications

Other Protein References for SERP2 Gene

No data available for DME Specific Peptides for SERP2 Gene

Domains & Families for SERP2 Gene

Protein Domains for SERP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6R1

UniProtKB/Swiss-Prot:

SERP2_HUMAN :
  • Belongs to the RAMP4 family.
Family:
  • Belongs to the RAMP4 family.
genes like me logo Genes that share domains with SERP2: view

No data available for Gene Families for SERP2 Gene

Function for SERP2 Gene

Molecular function for SERP2 Gene

UniProtKB/Swiss-Prot Function:
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Phenotypes for SERP2 Gene

GenomeRNAi human phenotypes for SERP2:
genes like me logo Genes that share phenotypes with SERP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERP2 Gene

Localization for SERP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP2 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERP2 Gene COMPARTMENTS Subcellular localization image for SERP2 gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SERP2: view

Pathways & Interactions for SERP2 Gene

SuperPathways for SERP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SERP2: view

No data available for Pathways by source and SIGNOR curated interactions for SERP2 Gene

Drugs & Compounds for SERP2 Gene

No Compound Related Data Available

Transcripts for SERP2 Gene

mRNA/cDNA for SERP2 Gene

Unigene Clusters for SERP2 Gene

Stress-associated endoplasmic reticulum protein family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SERP2 Gene

GeneLoc Exon Structure for
SERP2
ECgene alternative splicing isoforms for
SERP2

Expression for SERP2 Gene

mRNA expression in normal human tissues for SERP2 Gene

mRNA differential expression in normal tissues according to GTEx for SERP2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SERP2 Gene

This gene is overexpressed in Fetal Brain (39.7) and Frontal cortex (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERP2 Gene



SOURCE GeneReport for Unigene cluster for SERP2 Gene Hs.377972

genes like me logo Genes that share expression patterns with SERP2: view

Protein tissue co-expression partners for SERP2 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SERP2 Gene

Orthologs for SERP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERP2 35
  • 94.36 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SERP2 35
  • 96.92 (n)
  • 100 (a)
SERP2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serp2 35
  • 95.38 (n)
  • 100 (a)
Serp2 16
Serp2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERP2 35
  • 98.46 (n)
  • 95.38 (a)
SERP2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serp2 35
  • 92.59 (n)
  • 96.3 (a)
oppossum
(Monodelphis domestica)
Mammalia SERP2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serp2 35
  • 87.18 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii serp2 35
  • 84.1 (n)
  • 100 (a)
wufc96h11 35
serp1 36
  • 64 (a)
OneToMany
serp2 36
  • 100 (a)
OneToMany
SERP2 (2 of 3) 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10319 35
fruit fly
(Drosophila melanogaster)
Insecta CG32276 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59F4.2 36
  • 60 (a)
ManyToMany
T09A12.5 36
  • 54 (a)
ManyToMany
Species with no ortholog for SERP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP2 Gene

ENSEMBL:
Gene Tree for SERP2 (if available)
TreeFam:
Gene Tree for SERP2 (if available)

Paralogs for SERP2 Gene

Paralogs for SERP2 Gene

(1) SIMAP similar genes for SERP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERP2: view

Variants for SERP2 Gene

Sequence variations from dbSNP and Humsavar for SERP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs912590 -- 44,385,499(+) CATTG(C/T)CCTGG intron-variant
rs723927 -- 44,390,305(-) GCGGG(G/T)GGGTG intron-variant
rs1325326 -- 44,388,679(-) CTCCC(C/G)CAACC intron-variant
rs1175229 -- 44,378,398(+) ttcag(C/T)ctgaa intron-variant
rs1467624 -- 44,395,771(+) GACTC(A/G)TAATT intron-variant

Variation tolerance for SERP2 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERP2 Gene

HapMap Linkage Disequilibrium report
SERP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SERP2 Gene

Disorders for SERP2 Gene

Relevant External Links for SERP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERP2

No disorders were found for SERP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERP2 Gene

Publications for SERP2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SERP2 Gene

Sources for SERP2 Gene

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