SERP2 Gene
protein-coding GIFtS: 41
GCID: GC13P044947
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stress-associated endoplasmic reticulum protein family member...(Previous name: chromosome 13 open reading frame 21 )
(Previous symbol: C13orf21)
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Aliases
for SERP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Stress-Associated Endoplasmic Reticulum Protein Family Member 21 2 | | Chromosome 13 Open Reading Frame 211 | | C13orf211 2 3 | | RP11-269C23.12 | | BA269C23.11 | | Stress-Associated Endoplasmic Reticulum Protein 22 | | Ribosome-Associated Membrane Protein RAMP4-22 3 | | |
Export aliases for SERP2 gene to outside databasesPrevious GC identifers: GC13P043845 GC13P025749 |
Summaries
for SERP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SERP2_HUMAN, Q8N6R1Function: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. Mayprotect unfolded target proteins against degradation and facilitate correct glycosylation (Potential)
|
Genomic Views
for SERP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERP2 gene promoter:
LCR-F1 PPAR-alpha Pax-3 PPAR-gamma1 FOXJ2 (long isoform) FOXJ2 PPAR-gamma2 Pax-4a Hlf En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q14.11SERP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P044947: view genomic region
(about GC identifiers)
Start:
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44,947,801 bp from pter |
End:
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44,971,850 bp from pter |
Size:
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24,050 bases |
Orientation:
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plus strand |
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Proteins
for SERP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SERP2_HUMAN, Q8N6R1 (See
protein sequence)Recommended Name: Stress-associated endoplasmic reticulum protein 2 Size: 65 amino acids; 7431 Da
Subcellular location: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-passmembrane protein; Cytoplasmic side (Potential)Explore the universe of human proteins at neXtProt for SERP2: NX_Q8N6R1
SERP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010897.1
ENSEMBL proteins: ENSP00000433253 ENSP00000368477 ENSP00000435473
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SERP2 for ontologies About GeneDecksing
SERP2 Antibody Products:
Assay Products for SERP2: |
Protein
Domains /
Families
for SERP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N6R1ProtoNet protein and cluster: Q8N6R1 UniProtKB/Swiss-Prot: SERP2_HUMAN, Q8N6R1Similarity: Belongs to the RAMP4 family |
Function
for SERP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SERP2_HUMAN, Q8N6R1Function: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. Mayprotect unfolded target proteins against degradation and facilitate correct glycosylation (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERP2 (NM_001010897) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP2 |
|
Pathways & Interactions
for SERP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERP2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for SERP2 (Q8N6R13 ENSP000003684774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
SERP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SERP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERP2
Search CenterWatch for drugs/clinical trials and news about SERP2
|
Transcripts
for SERP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERP2 gene: NM_001010897.1 Unigene Cluster for SERP2: Stress-associated endoplasmic reticulum protein family member 2 Hs.377972 [show with all ESTs]Unigene Representative Sequence: AK1232123 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000474333 ENST00000379179(uc001uzj.3) ENST00000493476(uc021riy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERP2 (NM_001010897) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP2 |
Additional cDNA sequence: AK123212.1 BC029067.1 4 DOTS entries: DT.444436 DT.91678660 DT.95150911 DT.426564 24/83 AceView cDNA sequences (see all 83): AA493194 AA485112 AA485066 AA251005 AI268964 AI695047 AI916497 AA485113 BU951187 AK026218 AA485162 CR611312 AA284254 AI342808 AW294698 BE468144 BG149210 BG060085 BF446707 BX090890 BX356905 AI269031 AI082215 BF940441
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SERP2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for SERP2
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Expression
for SERP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCCTCTG
About this image
See SERP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERP2
SOURCE GeneReport for Unigene cluster: Hs.377972
SABiosciences Custom PCR Arrays for SERP2
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SERP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP2 |
Orthologs
for SERP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SERP2 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc96h112 |
Transcribed sequence with moderate similarity to protein more |
80.79(n) |
|
AL926796.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG322761 |
CG32276 |
68.82(n)
69.35(a) |
|
251645 NM_167998.2 NP_728830.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F59F4.26T09A12.56 |
-- |
58(a)51(a) |
many ↔ manymany ↔ many |
X(15841503-15842404) IV(8225662-8226747) |
ENSEMBL Gene Tree for SERP2 (if available)
TreeFam Gene Tree for SERP2 (if available) |
Paralogs
for SERP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERP2 gene
- SERP12
1 SIMAP similar gene for SERP2 using alignment to 3 protein entries: SERP2_HUMAN (see all proteins):SERP1
SERP2 for paralogs About GeneDecksing
|
Genomic Variants
for SERP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERP2 (44947801 - 44971850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERP2 |
|
Disorders
/ Diseases
for SERP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SERP2 for disorders About GeneDecksing
1  disease for SERP2: About MalaCardscowpox
Export disorders for SERP2 gene to outside databases
|
Publications
for SERP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SERP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SERP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SERP2 gene:
Search GeneIP for patents involving SERP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERP2 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for SERP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERP2 | | OriGene 3'-UTR Clone for SERP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SERP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERP2 | | OriGene Custom Protein Services for SERP2 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERP2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SERP2 |
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 | | | SERP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SERP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP2 |
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