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Aliases for SERP2 Gene

Aliases for SERP2 Gene

  • Stress Associated Endoplasmic Reticulum Protein Family Member 2 2 3 5
  • Ribosome-Associated Membrane Protein RAMP4-2 3 4
  • C13orf21 3 4
  • Stress-Associated Endoplasmic Reticulum Protein 2 3
  • Chromosome 13 Open Reading Frame 21 2
  • BA269C23.1 3

External Ids for SERP2 Gene

Previous HGNC Symbols for SERP2 Gene

  • C13orf21

Previous GeneCards Identifiers for SERP2 Gene

  • GC13P043845
  • GC13P044947
  • GC13P025749

Summaries for SERP2 Gene

GeneCards Summary for SERP2 Gene

SERP2 (Stress Associated Endoplasmic Reticulum Protein Family Member 2) is a Protein Coding gene. An important paralog of this gene is SERP1.

UniProtKB/Swiss-Prot for SERP2 Gene

  • May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERP2 Gene

Genomics for SERP2 Gene

Regulatory Elements for SERP2 Gene

Enhancers for SERP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G044300 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -66.2 -66181 14.8 FOXA2 SIN3A BRCA1 ZNF2 YY1 GATA2 CBX5 FOS JUNB GLIS1 SERP2 LACC1 SMIM2-IT1 SMIM2 SMIM2-AS1 CCDC122 TSC22D1 GC13M044319 GC13M044260
GH13G044292 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.6 -80.3 -80253 2.7 PKNOX1 JUN CEBPG RAD21 FOSL1 EED ETV6 RELB FOS IKZF2 SERP2 SMIM2 SMIM2-IT1 LACC1 CCDC122 GC13M044319 GC13M044260
GH13G044270 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -99.9 -99948 6.5 TBP ATF1 BMI1 RAD21 YY1 FOS CREM CEBPB NR2F2 IKZF1 NUFIP1 SERP2 SMIM2-AS1 LACC1 CCDC122 GC13M044260 GC13M044319
GH13G044294 1.1 FANTOM5 ENCODE dbSUPER 17.3 -78.5 -78544 0.3 ESRRA CEBPA NR2F6 SERP2 SMIM2 SMIM2-IT1 LACC1 CCDC122 GC13M044319 GC13M044260
GH13G044242 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -129.9 -129876 2.6 CTCF PKNOX1 ESRRA FOXA2 ZBTB21 JUN SIN3A ZIC2 RAD21 FOSL1 SERP2 LACC1 ENSG00000230731 GC13M044260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERP2 on UCSC Golden Path with GeneCards custom track

Promoters for SERP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000062143 335 1200 ZNF202 MAZ CREB3L1 ZNF473 SP2 ZNF501 ZIC2 ZNF518A GLIS1 ZNF24

Genomic Location for SERP2 Gene

Chromosome:
13
Start:
44,373,665 bp from pter
End:
44,397,714 bp from pter
Size:
24,050 bases
Orientation:
Plus strand

Genomic View for SERP2 Gene

Genes around SERP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP2 Gene

Proteins for SERP2 Gene

  • Protein details for SERP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6R1-SERP2_HUMAN
    Recommended name:
    Stress-associated endoplasmic reticulum protein 2
    Protein Accession:
    Q8N6R1

    Protein attributes for SERP2 Gene

    Size:
    65 amino acids
    Molecular mass:
    7431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERP2 Gene

Post-translational modifications for SERP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERP2 Gene

No data available for DME Specific Peptides for SERP2 Gene

Domains & Families for SERP2 Gene

Protein Domains for SERP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6R1

UniProtKB/Swiss-Prot:

SERP2_HUMAN :
  • Belongs to the RAMP4 family.
Family:
  • Belongs to the RAMP4 family.
genes like me logo Genes that share domains with SERP2: view

No data available for Gene Families for SERP2 Gene

Function for SERP2 Gene

Molecular function for SERP2 Gene

UniProtKB/Swiss-Prot Function:
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).

Gene Ontology (GO) - Molecular Function for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERP2: view

Phenotypes for SERP2 Gene

genes like me logo Genes that share phenotypes with SERP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERP2 Gene

Localization for SERP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP2 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERP2 gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERP2: view

Pathways & Interactions for SERP2 Gene

SuperPathways for SERP2 Gene

No Data Available

Interacting Proteins for SERP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368477%0d%0a9606.ENSP00000299198%0d%0a
Selected Interacting proteins: Q8N6R1-SERP2_HUMAN ENSP00000368477 for SERP2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SERP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with SERP2: view

No data available for Pathways by source and SIGNOR curated interactions for SERP2 Gene

Drugs & Compounds for SERP2 Gene

No Compound Related Data Available

Transcripts for SERP2 Gene

mRNA/cDNA for SERP2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERP2 Gene

Stress-associated endoplasmic reticulum protein family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SERP2 Gene

GeneLoc Exon Structure for
SERP2
ECgene alternative splicing isoforms for
SERP2

Expression for SERP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERP2 Gene

mRNA differential expression in normal tissues according to GTEx for SERP2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SERP2 Gene

This gene is overexpressed in Fetal Brain (39.7) and Frontal cortex (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERP2 Gene



Protein tissue co-expression partners for SERP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERP2 Gene:

SERP2

SOURCE GeneReport for Unigene cluster for SERP2 Gene:

Hs.377972

Evidence on tissue expression from TISSUES for SERP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SERP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERP2 Gene

Orthologs for SERP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERP2 34 35
  • 98.46 (n)
dog
(Canis familiaris)
Mammalia SERP2 34 35
  • 96.92 (n)
mouse
(Mus musculus)
Mammalia Serp2 34 16 35
  • 95.38 (n)
cow
(Bos Taurus)
Mammalia SERP2 34
  • 94.36 (n)
rat
(Rattus norvegicus)
Mammalia Serp2 34
  • 92.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SERP2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serp2 34
  • 87.18 (n)
zebrafish
(Danio rerio)
Actinopterygii serp2 34 35
  • 84.1 (n)
SERP2 (2 of 3) 35
  • 71 (a)
OneToMany
serp1 35
  • 64 (a)
OneToMany
wufc96h11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10319 34
fruit fly
(Drosophila melanogaster)
Insecta CG32276 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59F4.2 35
  • 60 (a)
ManyToMany
T09A12.5 35
  • 54 (a)
ManyToMany
Species where no ortholog for SERP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP2 Gene

ENSEMBL:
Gene Tree for SERP2 (if available)
TreeFam:
Gene Tree for SERP2 (if available)

Paralogs for SERP2 Gene

Paralogs for SERP2 Gene

(1) SIMAP similar genes for SERP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERP2: view

Variants for SERP2 Gene

Sequence variations from dbSNP and Humsavar for SERP2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000154772 -- 44,383,344(+) ACCCA(C/T)CTCTT intron-variant
rs1000286520 -- 44,390,303(+) CCCAC(C/G)CACCC intron-variant, upstream-variant-2KB
rs1000344744 -- 44,377,956(+) CAGAT(A/G)TTAAA intron-variant
rs1000484476 -- 44,383,704(+) CACCA(C/T)GCCCA intron-variant
rs1000517203 -- 44,390,611(+) GGGCA(-/T)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERP2 Gene

Variant ID Type Subtype PubMed ID
nsv1122813 CNV deletion 24896259

Variation tolerance for SERP2 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERP2 Gene

Disorders for SERP2 Gene

Relevant External Links for SERP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERP2

No disorders were found for SERP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERP2 Gene

Publications for SERP2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 3 64
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64

Products for SERP2 Gene

Sources for SERP2 Gene

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