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Aliases for SERP1 Gene

Aliases for SERP1 Gene

  • Stress-Associated Endoplasmic Reticulum Protein 1 2 3
  • Ribosome Associated Membrane Protein 4 2 3
  • Ribosome-Attached Membrane Protein 4 3 4
  • RAMP4 3 4

External Ids for SERP1 Gene

Summaries for SERP1 Gene

GeneCards Summary for SERP1 Gene

SERP1 (Stress-Associated Endoplasmic Reticulum Protein 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. An important paralog of this gene is SERP2.

UniProtKB/Swiss-Prot for SERP1 Gene

  • Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

Gene Wiki entry for SERP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERP1 Gene

Genomics for SERP1 Gene

Genomic Location for SERP1 Gene

Start:
150,541,993 bp from pter
End:
150,603,228 bp from pter
Size:
61,236 bases
Orientation:
Minus strand

Genomic View for SERP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP1 Gene

Regulatory Elements for SERP1 Gene

Proteins for SERP1 Gene

  • Protein details for SERP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X1-SERP1_HUMAN
    Recommended name:
    Stress-associated endoplasmic reticulum protein 1
    Protein Accession:
    Q9Y6X1
    Secondary Accessions:
    • D3DNI6

    Protein attributes for SERP1 Gene

    Size:
    66 amino acids
    Molecular mass:
    7374 Da
    Quaternary structure:
    • Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).

neXtProt entry for SERP1 Gene

Proteomics data for SERP1 Gene at MOPED

Post-translational modifications for SERP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SERP1 Gene

Domains for SERP1 Gene

Protein Domains for SERP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SERP1_HUMAN
Family:
  • Belongs to the RAMP4 family.:
    • Q9Y6X1
genes like me logo Genes that share domains with SERP1: view

No data available for Gene Families for SERP1 Gene

Function for SERP1 Gene

Molecular function for SERP1 Gene

UniProtKB/Swiss-Prot Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

Gene Ontology (GO) - Molecular Function for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERP1: view
genes like me logo Genes that share phenotypes with SERP1: view

Animal Models for SERP1 Gene

MGI Knock Outs for SERP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERP1 Gene

Localization for SERP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP1 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERP1 Gene COMPARTMENTS Subcellular localization image for SERP1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 10601334
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 10601334
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with SERP1: view

Pathways for SERP1 Gene

genes like me logo Genes that share pathways with SERP1: view

Gene Ontology (GO) - Biological Process for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006464 cellular protein modification process TAS 10601334
GO:0006486 protein glycosylation IEA --
GO:0006950 response to stress TAS 10601334
genes like me logo Genes that share ontologies with SERP1: view

Transcripts for SERP1 Gene

Unigene Clusters for SERP1 Gene

Stress-associated endoplasmic reticulum protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3: - -

Relevant External Links for SERP1 Gene

GeneLoc Exon Structure for
SERP1
ECgene alternative splicing isoforms for
SERP1

Expression for SERP1 Gene

mRNA expression in normal human tissues for SERP1 Gene

SOURCE GeneReport for Unigene cluster for SERP1 Gene Hs.713956

genes like me logo Genes that share expressions with SERP1: view

Orthologs for SERP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERP1 36
  • 99.49 (n)
  • 100 (a)
SERP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERP1 36
  • 96.46 (n)
  • 100 (a)
SERP1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serp1 36
  • 95.96 (n)
  • 100 (a)
Serp1 16
Serp1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERP1 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serp1 36
  • 94.95 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25641 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75578 36
serp1 36
  • 81.82 (n)
  • 92.42 (a)
zebrafish
(Danio rerio)
Actinopterygii SERP1 37
  • 91 (a)
OneToOne
zgc:92744 36
  • 78.97 (n)
  • 90.77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001548 36
  • 70.31 (n)
  • 78.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32276 36
  • 64.52 (n)
  • 69.35 (a)
CG32276 37
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59F4.2 37
  • 52 (a)
ManyToMany
T09A12.5 37
  • 54 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5427 36
Species with no ortholog for SERP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP1 Gene

ENSEMBL:
Gene Tree for SERP1 (if available)
TreeFam:
Gene Tree for SERP1 (if available)

Paralogs for SERP1 Gene

Paralogs for SERP1 Gene

Selected SIMAP similar genes for SERP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERP1: view

Variants for SERP1 Gene

Sequence variations from dbSNP and Humsavar for SERP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8052 -- 150,542,155(+) TAGAG(C/T)TAAAC utr-variant-3-prime
rs10272 -- 150,543,066(-) ACAGC(A/G)TGAAC utr-variant-3-prime
rs1050087 -- 150,542,342(-) AAAGC(A/C)CAATG utr-variant-3-prime
rs1050091 -- 150,544,254(-) AAAAC(A/C)CCACA utr-variant-3-prime
rs1533816 -- 150,544,531(+) ATAAG(C/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERP1 Gene

Variant ID Type Subtype PubMed ID
nsv511101 CNV Complex 20534489

Relevant External Links for SERP1 Gene

HapMap Linkage Disequilibrium report
SERP1

Disorders for SERP1 Gene

Relevant External Links for SERP1

Genetic Association Database (GAD)
SERP1
Human Genome Epidemiology (HuGE) Navigator
SERP1
genes like me logo Genes that share disorders with SERP1: view

No data available for UniProtKB/Swiss-Prot for SERP1 Gene

Publications for SERP1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PMID: 10601334) Yamaguchi A. … Tohyama M. (J. Cell Biol. 1999) 2 3
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for SERP1 Gene

  • Addgene plasmids for SERP1

Sources for SERP1 Gene

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