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SERP1 Gene

protein-coding GIFtS: 50
GCID: GC03M150259

Stress-Associated Endoplasmic Reticulum Protein 1

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stress-Associated Endoplasmic Reticulum Protein 1¹ ²
Ribosome Associated Membrane Protein 4¹ ²
Ribosome-Attached Membrane Protein 4² ³
RAMP4² ³

External Ids:	HGNC: 10759¹	Entrez Gene: 27230²	Ensembl: ENSG00000120742⁷	UniProtKB: Q9Y6X1³

ORGUL members:

Export aliases for SERP1 gene to outside databases

Previous GC identifers: GC03M147184 GC03M151145 GC03M151541 GC03M151581 GC03M151742 GC03M147634

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERP1 Gene:

SERP1 (stress-associated endoplasmic reticulum protein 1) is a protein-coding gene. An important paralog of this gene is SERP2.

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1

Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target

proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By

similarity)

Gene Wiki entry for SERP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the SERP1 gene promoter:
CHOP-10 SRY NF-1 AML1a USF-1 USF-1:USF-2 POU3F2 GATA-2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERP1 promoter sequence

Search Chromatin IP Primers for SERP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1

SERP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERP1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M150259: view genomic region (about GC identifiers)

Start:	150,259,780 bp from pter	End:	150,321,015 bp from pter
Size:	61,236 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1 (See protein sequence)

Recommended Name: Stress-associated endoplasmic reticulum protein 1

Size: 66 amino acids; 7374 Da

Subunit: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity)

Secondary accessions: D3DNI6

Explore the universe of human proteins at neXtProt for SERP1: NX_Q9Y6X1

Explore proteomics data for SERP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SERP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055260.1

ENSEMBL proteins:

ENSP00000420076 ENSP00000420002 ENSP00000419472 ENSP00000239944

Reactome Protein details: Q9Y6X1

SERP1 Human Recombinant Protein Products:

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	Novus Biologicals SERP1 Lysate
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	Cloud-Clone Corp. Proteins for SERP1
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	Search antibodies-online for proteins for SERP1
	antibodies-online peptides for SERP1

SERP1 Antibody Products:

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	Abcam antibodies for SERP1
	Cloud-Clone Corp. Antibodies for SERP1
	ThermoFisher Antibodies for SERP1
	antibodies-online antibodies for SERP1 (10 products)

SERP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for SERP1 Cloud-Clone Corp. CLIAs for SERP1
	Search eBioscience for ELISAs for SERP1
	antibodies-online kits for SERP1 (9 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR010580 ER_stress-assoc

Graphical View of Domain Structure for InterPro Entry Q9Y6X1

ProtoNet protein and cluster: Q9Y6X1

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1

Similarity: Belongs to the RAMP4 family

Find genes that share domains with SERP1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SERP1_HUMAN, Q9Y6X1

Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target

proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By

similarity)

Phenotypes:
1 GenomeRNAi human phenotype for SERP1:

Decreased Wnt reporter activit

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serp1):

endocrine/exocrine gland	growth/size/body	homeostasis/metabolism	mortality/aging	muscle
nervous system	skeleton

Find genes that share phenotypes with SERP1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Serp1^tm1Hori for SERP1

genOway: Develop your customized and physiologically relevant rodent model for SERP1

miRNA Products:		miRTarBase miRNAs that target SERP1: hsa-mir-7-5p (MIRT025860), hsa-mir-1 (MIRT002806), hsa-mir-124-3p (MIRT002684), hsa-mir-744-5p (MIRT037576), hsa-mir-204-5p (MIRT005843), hsa-mir-186-5p (MIRT044942), hsa-mir-98-5p (MIRT004944), hsa-mir-375 (MIRT019926)

		Block miRNA regulation of human, mouse, rat SERP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SERP1 (see all 63):
		hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SERP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SERP1
		Predesigned siRNA for gene silencing in human, mouse, rat SERP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SERP1

Clone Products:		OriGene clones in human, mouse for SERP1 (see all 6) OriGene ORF clones in mouse, rat for SERP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
		Sino Biological Human cDNA Clone for SERP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1
		Addgene plasmids for SERP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for SERP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SERP1_HUMAN, Q9Y6X1: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass

membrane protein; Cytoplasmic side (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
endoplasmic reticulum	5
extracellular	2
mitochondrion	2
cytosol	1
nucleus	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	10601334
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005840	ribosome	TAS	10601334
GO:0005881	cytoplasmic microtubule	IDA	--
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with SERP1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SERP1 About

See pathways by source

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by

SuperPath

Contained pathways About

Unfolded Protein Response

	Unfolded Protein Response	0.61			Activation of Chaperone Genes by XBP1(S)	0.59
	Activation of Chaperones by IRE1alpha	0.61

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Metabolism of proteins

0.30

Find genes that share SuperPaths with SERP1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for SERP1

XBP1(S) activates chaperone genes

Pathway & Disease-focused RT² Profiler PCR Arrays including SERP1:

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for SERP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for SERP1 (Q9Y6X1³ ENSP00000239944⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379³, ENSP00000365131⁴	I2D: score=1 STRING: ENSP00000365131
ENSG00000096155	P46379³	I2D: score=1
ENSG00000227761	P46379³	I2D: score=1
ENSG00000228760	P46379³	I2D: score=1
ENSG00000229524	P46379³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006006	glucose metabolic process	IEA	--
GO:0006464	cellular protein modification process	TAS	10601334
GO:0006486	protein glycosylation	IEA	--
GO:0006950	response to stress	TAS	10601334

Find genes that share ontologies with SERP1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SERP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SERP1 gene:

NM_014445.3

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479209(uc003exy.3 uc003exz.3) ENST00000487153 ENST00000491660

ENST00000491195 ENST00000490945(uc003eye.2) ENST00000463647 ENST00000484608

ENST00000239944

miRNA Products:		Block miRNA regulation of human, mouse, rat SERP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SERP1 (see all 63):
		hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SERP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SERP1
		Predesigned siRNA for gene silencing in human, mouse, rat SERP1

Clone Products:		OriGene clones in human, mouse for SERP1 (see all 6) OriGene ORF clones in mouse, rat for SERP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1
		Addgene plasmids for SERP1

Primer Products:		OriGene qPCR primer pairs and template standards for SERP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SERP1
		QuantiTect SYBR Green Assays in human, mouse, rat SERP1
		QuantiFast Probe-based Assays in human, mouse, rat SERP1

Selected AceView cDNA sequences (see all 1031):

BM968138 AI352670 CB156528 BX402124 BQ014658 CA449119 AA809880 BU543846

AI494421 BU741566 AI093256 CA396606 Z40054 BM478798 BP343745 BM985079

BM916491 BQ645251 BQ670283 BU619460 T82287 CR533472 AI480022 AA865907

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SERP1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:							-
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for SERP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SERP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

SERP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SERP1 Protein Expression

Pathway & Disease-focused RT² Profiler PCR Arrays including SERP1:

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for SERP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SERP1
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		QuantiFast Probe-based Assays in human, mouse, rat SERP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SERP1 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Serp1^{1 , 5}	stress-associated endoplasmic reticulum protein 1^{1, 5}	95.96(n)¹ 100(a)¹		3 (28.58 cM)⁵ 28146¹ NM_030685.3¹ NP_109610.1¹ 58521969⁵
African clawed frog (Xenopus laevis)	Amphibia	Xl.25641²	Xenopus laevis transcribed sequence with weak similarity more	84.06(n)		CA789435.1
zebrafish (Danio rerio)	Actinopterygii	zgc:92744¹	zgc:92744	78.97(n) 90.77(a)		436846 NM_001002573.2 NP_001002573.1
fruit fly (Drosophila melanogaster)	Insecta	CG32276¹	CG32276	64.52(n) 69.35(a)		251645 NM_167999.3 NP_728831.1
worm (Caenorhabditis elegans)	Secernentea	T09A12.5⁶ F59F4.2⁶	Protein F59F4.2 (F59F4.2) mRNA, complete cds	54(a) 52(a)	many ↔ many many ↔ many	IV(8225676-8226761) WBGene00020374 X(15841572-15842473) WBGene00010337

ENSEMBL Gene Tree for SERP1 (if available)
TreeFam Gene Tree for SERP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SERP1 gene

SERP2²

1 SIMAP similar gene for SERP1 using alignment to 3 protein entries: SERP1_HUMAN (see all proteins):

SERP2

Find genes that share paralogs with SERP1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191881688^1,2		--	150259298(+)	`CCATGC/TCCCTT`	1	--	int¹		0	--	--	--	--
rs184387393^1,2		--	150259377(+)	`CTAGCC/TTTTTA`	1	--	int¹		0	--	--	--	--
rs73001321^1,2	C	--	150259386(+)	`TATTGC/TTCATT`	1	--	int¹		1		WA	2
rs190009359^1,2		--	150259417(+)	`ACATGA/TGTCCT`	1	--	int¹		0	--	--	--	--
rs182394267^1,2		--	150259420(+)	`TGTGTC/GCTAAT`	1	--	int¹		0	--	--	--	--
rs77567250^1,2	C	--	150259467(+)	`GGTAC-/TAAG TAAGT`	1	--	int¹		0	--	--	--	--
rs60104080^1,2	C	--	150259468(+)	`TAAGT-/AAGT TTAGA`	1	--	int¹		1		NA	2
rs141087529^1,2	C	--	150259490(+)	`AAATGC/TTTCTC`	1	--	int¹		0	--	--	--	--
rs11922157^1,2	C,F,A,H	--	150259668(+)	`AAGCAT/CAATAA`	1	--	int¹		23		NS EA NA WA CSA	2350
rs8052^1,2	C,F,O,A,H	--	150259942(+)	`TAGAGC/TTAAAC`	1	--	ut3¹		36		MN EA NA NS WA CSA	3315

HapMap Linkage Disequilibrium report for SERP1 (150259780 - 150321015 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SERP1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv511101	CNV	Complex	20534489

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SERP1

DNA2.0 Custom Variant and Variant Library Synthesis for SERP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with SERP1 About GenesLikeMe

Genetic Association Database (GAD): SERP1
Human Genome Epidemiology (HuGE) Navigator: SERP1 (3 documents)

Export disorders for SERP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SERP1 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with SERP1)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (Genome Res. 2001)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PubMed id 10601334)^{1, 3} Yamaguchi A....Tohyama M. (J. Cell Biol. 1999)
Regulation of ENaC biogenesis by the stress response protein SERP1. (PubMed id 22526458)¹ Faria D....Kunzelmann K. (Pflugers Arch. 2012)
SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. (PubMed id 22419128)¹ Atschekzei F....Serth J. (Epigenetics 2012)
HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. (PubMed id 21956116)¹ Chang J.R....Sawaya B.E. (J. Biol. Chem. 2011)
Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)¹ Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. (PubMed id 21816823)¹ Mukerjee R....Sawaya B.E. (J. Biol. Chem. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27230	HGNC: 10759	AceView: SERP1	Ensembl:ENSG00000120742	euGenes: HUgn27230
ECgene: SERP1	H-InvDB: SERP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SERP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERP1 gene:
Search GeneIP for patents involving SERP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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SERP1 Gene

Stress-Associated Endoplasmic Reticulum Protein 1

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SERP1 Gene

Stress-Associated Endoplasmic Reticulum Protein 1

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