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SERP1 Gene

protein-coding   GIFtS: 50
GCID: GC03M150259

Stress-Associated Endoplasmic Reticulum Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stress-Associated Endoplasmic Reticulum Protein 11 2
Ribosome Associated Membrane Protein 41 2
Ribosome-Attached Membrane Protein 42 3
RAMP42 3

External Ids:    HGNC: 107591   Entrez Gene: 272302   Ensembl: ENSG000001207427   UniProtKB: Q9Y6X13   
ORGUL members:         

Export aliases for SERP1 gene to outside databases

Previous GC identifers: GC03M147184 GC03M151145 GC03M151541 GC03M151581 GC03M151742 GC03M147634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERP1 Gene:
SERP1 (stress-associated endoplasmic reticulum protein 1) is a protein-coding gene. Diseases associated with SERP1 include cowpox, and hiv-1. An important paralog of this gene is SERP2.

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1
Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.
Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target
proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By
similarity)

Gene Wiki entry for SERP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SERP1 gene promoter:
         CHOP-10   SRY   NF-1   AML1a   USF-1   USF-1:USF-2   POU3F2   GATA-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERP1 promoter sequence
   Search Chromatin IP Primers for SERP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

SERP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M150259:  view genomic region     (about GC identifiers)

Start:
150,259,780 bp from pter      End:
150,321,015 bp from pter
Size:
61,236 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1 (See protein sequence)
Recommended Name: Stress-associated endoplasmic reticulum protein 1  
Size: 66 amino acids; 7374 Da
Subunit: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity)
Secondary accessions: D3DNI6

Explore the universe of human proteins at neXtProt for SERP1: NX_Q9Y6X1

Explore proteomics data for SERP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055260.1  
    ENSEMBL proteins: 
     ENSP00000420076   ENSP00000420002   ENSP00000419472   ENSP00000239944  
    Reactome Protein details: Q9Y6X1

    SERP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERP1
    OriGene Protein Over-expression Lysate for SERP1
    OriGene MassSpec for SERP1
    OriGene Custom Protein Services for SERP1
    GenScript Custom Purified and Recombinant Proteins Services for SERP1
    Novus Biologicals SERP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERP1

    SERP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SERP1
    OriGene Custom Antibody Services for SERP1
    Novus Biologicals SERP1 Antibody
    Abcam antibodies for SERP1
    Cloud-Clone Corp. Antibodies for SERP1
    ThermoFisher Antibodies for SERP1
    LSBio Antibodies in human, mouse, rat for SERP1

    SERP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SERP1
    Cloud-Clone Corp. CLIAs for SERP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010580 ER_stress-assoc

    Graphical View of Domain Structure for InterPro Entry Q9Y6X1

    ProtoNet protein and cluster: Q9Y6X1

    UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1
    Similarity: Belongs to the RAMP4 family


    SERP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERP1_HUMAN, Q9Y6X1
    Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.
    Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target
    proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By
    similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for SERP1:

     Decreased Wnt reporter activit 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serp1):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  skeleton 

    SERP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serp1tm1Hori for SERP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERP1:
    hsa-mir-7-5p (MIRT025860), hsa-mir-1 (MIRT002806), hsa-mir-124-3p (MIRT002684), hsa-mir-744-5p (MIRT037576), hsa-mir-204-5p (MIRT005843), hsa-mir-186-5p (MIRT044942), hsa-mir-98-5p (MIRT004944), hsa-mir-375 (MIRT019926)

    Block miRNA regulation of human, mouse, rat SERP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERP1 (see all 63):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSERP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERP1
    Predesigned siRNA for gene silencing in human, mouse, rat SERP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERP1

    Clone
    Products:
         
    OriGene clones in human, mouse for SERP1 (see all 6)
    OriGene ORF clones in mouse, rat for SERP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
    Sino Biological Human cDNA Clone for SERP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SERP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SERP1_HUMAN, Q9Y6X1: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass
    membrane protein; Cytoplasmic side (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    extracellular2
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS10601334
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005840ribosome TAS10601334
    GO:0005881cytoplasmic microtubule IDA--
    GO:0016021integral component of membrane IEA--

    SERP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SERP1
        XBP1(S) activates chaperone genes



    SERP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERP1: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SERP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SERP1 (Q9Y6X13 ENSP000002399444) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793, ENSP000003651314I2D: score=1 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    ENSG00000228760P463793I2D: score=1 
    ENSG00000229524P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0006464cellular protein modification process TAS10601334
    GO:0006486protein glycosylation IEA--
    GO:0006950response to stress TAS10601334

    SERP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERP1 gene: 
    NM_014445.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479209(uc003exy.3 uc003exz.3) ENST00000487153 ENST00000491660
    ENST00000491195 ENST00000490945(uc003eye.2) ENST00000463647 ENST00000484608
    ENST00000239944
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERP1 (see all 63):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSERP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERP1
    Predesigned siRNA for gene silencing in human, mouse, rat SERP1
    Clone
    Products:
         
    OriGene clones in human, mouse for SERP1 (see all 6)
    OriGene ORF clones in mouse, rat for SERP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERP1
      QuantiTect SYBR Green Assays in human, mouse, rat SERP1
      QuantiFast Probe-based Assays in human, mouse, rat SERP1

    Selected AceView cDNA sequences (see all 1031):

    BM968138 AI352670 CB156528 BX402124 BQ014658 CA449119 AA809880 BU543846 
    AI494421 BU741566 AI093256 CA396606 Z40054 BM478798 BP343745 BM985079 
    BM916491 BQ645251 BQ670283 BU619460 T82287 CR533472 AI480022 AA865907 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SERP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                    -               
    SP2:                                    
    SP3:              -     -               


    ECgene alternative splicing isoforms for SERP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERP1 Expression
    About this image

    SERP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERP1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SERP1: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SERP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERP1
    QuantiTect SYBR Green Assays in human, mouse, rat SERP1
    QuantiFast Probe-based Assays in human, mouse, rat SERP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SERP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serp11 , 5 stress-associated endoplasmic reticulum protein 11, 5 95.96(n)1
    100(a)1
      3 (28.58 cM)5
    281461  NM_030685.31  NP_109610.11 
     585219695 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256412 Xenopus laevis transcribed sequence with weak similarity more 84.06(n)    CA789435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:927441 zgc:92744 78.97(n)
    90.77(a)
      436846  NM_001002573.2  NP_001002573.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322761 CG32276 64.52(n)
    69.35(a)
      251645  NM_167999.3  NP_728831.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T09A12.56
    F59F4.26
    Protein F59F4.2 (F59F4.2) mRNA, complete cds
    54(a)
    52(a)
    many ↔ many
    many ↔ many
    IV(8225676-8226761) WBGene00020374
    X(15841572-15842473) WBGene00010337


    ENSEMBL Gene Tree for SERP1 (if available)
    TreeFam Gene Tree for SERP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERP1 gene
    SERP22  
    1 SIMAP similar gene for SERP1 using alignment to 3 protein entries:     SERP1_HUMAN (see all proteins):
    SERP2

    SERP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERP1 (see all 66)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918816881,2
    --150259298(+) CCATGC/TCCCTT 1 -- int10--------
    rs1843873931,2
    --150259377(+) CTAGCC/TTTTTA 1 -- int10--------
    rs730013211,2
    C--150259386(+) TATTGC/TTCATT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1900093591,2
    --150259417(+) ACATGA/TGTCCT 1 -- int10--------
    rs1823942671,2
    --150259420(+) TGTGTC/GCTAAT 1 -- int10--------
    rs775672501,2
    C--150259467(+) GGTAC-/TAAG  
            
    TAAGT
    1 -- int10--------
    rs601040801,2
    C--150259468(+) TAAGT-/AAGT  
            
    TTAGA
    1 -- int11Minor allele frequency- AAGT:0.00NA 2
    rs1410875291,2
    C--150259490(+) AAATGC/TTTCTC 1 -- int10--------
    rs119221571,2
    C,F,A,H--150259668(+) AAGCAT/CAATAA 1 -- int123Minor allele frequency- C:0.46NS EA NA WA CSA 2350
    rs80521,2
    C,F,O,A,H--150259942(+) TAGAGC/TTAAAC 1 -- ut3136Minor allele frequency- T:0.22MN EA NA NS WA CSA 3315

    HapMap Linkage Disequilibrium report for SERP1 (150259780 - 150321015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SERP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv511101CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    3 diseases for SERP1:    
    About MalaCards
    cowpox    hiv-1    neuronitis


    SERP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERP1
    Human Genome Epidemiology (HuGE) Navigator: SERP1 (3 documents)

    Export disorders for SERP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SERP1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SERP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PubMed id 10601334)1, 3 Yamaguchi A....Tohyama M. (J. Cell Biol. 1999)
    6. Regulation of ENaC biogenesis by the stress response protein SERP1. (PubMed id 22526458)1 Faria D....Kunzelmann K. (Pflugers Arch. 2012)
    7. SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. (PubMed id 22419128)1 Atschekzei F....Serth J. (Epigenetics 2012)
    8. HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. (PubMed id 21956116)1 Chang J.R....Sawaya B.E. (J. Biol. Chem. 2011)
    9. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    10. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. (PubMed id 21816823)1 Mukerjee R....Sawaya B.E. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27230 HGNC: 10759 AceView: SERP1 Ensembl:ENSG00000120742 euGenes: HUgn27230
    ECgene: SERP1 H-InvDB: SERP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERP1 gene:
    Search GeneIP for patents involving SERP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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