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Aliases for SERP1 Gene

Aliases for SERP1 Gene

  • Stress Associated Endoplasmic Reticulum Protein 1 2 3 5
  • Ribosome Associated Membrane Protein 4 2 3
  • Ribosome-Attached Membrane Protein 4 3 4
  • RAMP4 3 4
  • Stress-Associated Endoplasmic Reticulum Protein 1 3

External Ids for SERP1 Gene

Previous GeneCards Identifiers for SERP1 Gene

  • GC03M147184
  • GC03M151145
  • GC03M151541
  • GC03M151581
  • GC03M151742
  • GC03M150259
  • GC03M147634

Summaries for SERP1 Gene

GeneCards Summary for SERP1 Gene

SERP1 (Stress Associated Endoplasmic Reticulum Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Unfolded Protein Response (UPR). An important paralog of this gene is SERP2.

UniProtKB/Swiss-Prot for SERP1 Gene

  • Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

Gene Wiki entry for SERP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERP1 Gene

Genomics for SERP1 Gene

Regulatory Elements for SERP1 Gene

Enhancers for SERP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G150543 1.4 ENCODE dbSUPER 7.4 +57.0 56958 4.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 EIF2A SERP1 SELENOT GC03M150475
GH03G150634 0.8 Ensembl ENCODE 11.7 -32.8 -32755 2.1 MTA2 TCF7 ZSCAN29 EBF1 SPI1 SELENOT SERP1 ERICH6 ERICH6-AS1 EIF2A GC03P150627
GH03G150733 2 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -136.2 -136186 12.4 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 SIAH2 SIAH2-AS1 ERICH6 ERICH6-AS1 TSC22D2 SERP1 CLRN1 PIR41342 LOC101928105
GH03G150384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +218.1 218085 1.9 HDGF PKNOX1 ATF1 MLX ARID4B TCF12 CBX5 ZNF207 PPARG TBX21 TSC22D2 SERP1 SIAH2 LINC01214
GH03G150662 0.6 Ensembl 11.3 -59.5 -59473 0.2 ZNF316 L3MBTL2 NRF1 MAFG NFE2 EMSY ERICH6-AS1 ERICH6 SELENOT SERP1 ENSG00000243273 MINDY4B GC03P150627
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERP1 on UCSC Golden Path with GeneCards custom track

Promoters for SERP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160152 -273 2600 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for SERP1 Gene

Chromosome:
3
Start:
150,541,993 bp from pter
End:
150,603,228 bp from pter
Size:
61,236 bases
Orientation:
Minus strand

Genomic View for SERP1 Gene

Genes around SERP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERP1 Gene

Proteins for SERP1 Gene

  • Protein details for SERP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X1-SERP1_HUMAN
    Recommended name:
    Stress-associated endoplasmic reticulum protein 1
    Protein Accession:
    Q9Y6X1
    Secondary Accessions:
    • D3DNI6

    Protein attributes for SERP1 Gene

    Size:
    66 amino acids
    Molecular mass:
    7374 Da
    Quaternary structure:
    • Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).

neXtProt entry for SERP1 Gene

Post-translational modifications for SERP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERP1 Gene

No data available for DME Specific Peptides for SERP1 Gene

Domains & Families for SERP1 Gene

Protein Domains for SERP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X1

UniProtKB/Swiss-Prot:

SERP1_HUMAN :
  • Belongs to the RAMP4 family.
Family:
  • Belongs to the RAMP4 family.
genes like me logo Genes that share domains with SERP1: view

No data available for Gene Families for SERP1 Gene

Function for SERP1 Gene

Molecular function for SERP1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

Gene Ontology (GO) - Molecular Function for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SERP1: view
genes like me logo Genes that share phenotypes with SERP1: view

Animal Models for SERP1 Gene

MGI Knock Outs for SERP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERP1 Gene

Localization for SERP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERP1 Gene

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERP1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 5
extracellular 2
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 10601334
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 10601334
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with SERP1: view

Pathways & Interactions for SERP1 Gene

genes like me logo Genes that share pathways with SERP1: view

Gene Ontology (GO) - Biological Process for SERP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006464 cellular protein modification process TAS 10601334
GO:0006486 protein glycosylation IBA,TAS --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SERP1: view

No data available for SIGNOR curated interactions for SERP1 Gene

Transcripts for SERP1 Gene

Unigene Clusters for SERP1 Gene

Stress-associated endoplasmic reticulum protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3: - -

Relevant External Links for SERP1 Gene

GeneLoc Exon Structure for
SERP1
ECgene alternative splicing isoforms for
SERP1

Expression for SERP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SERP1 Gene:

SERP1

SOURCE GeneReport for Unigene cluster for SERP1 Gene:

Hs.713956

Evidence on tissue expression from TISSUES for SERP1 Gene

  • Nervous system(4.9)
  • Intestine(4.5)
  • Lung(4.5)
  • Adrenal gland(4.4)
  • Kidney(4.3)
  • Pancreas(4.3)
  • Skin(4)
  • Liver(3.8)
  • Eye(3.5)
  • Blood(3.4)
  • Stomach(3)
  • Spleen(2.4)
  • Bone(2)
genes like me logo Genes that share expression patterns with SERP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERP1 Gene

Orthologs for SERP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERP1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SERP1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERP1 34 35
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia SERP1 34 35
  • 96.46 (n)
mouse
(Mus musculus)
Mammalia Serp1 34 16 35
  • 95.96 (n)
rat
(Rattus norvegicus)
Mammalia Serp1 34
  • 94.95 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia serp1 34
  • 81.82 (n)
MGC75578 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25641 34
zebrafish
(Danio rerio)
Actinopterygii SERP1 35
  • 91 (a)
OneToOne
zgc:92744 34
  • 78.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001548 34
  • 70.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32276 34 35
  • 64.52 (n)
worm
(Caenorhabditis elegans)
Secernentea T09A12.5 35
  • 54 (a)
ManyToMany
F59F4.2 35
  • 52 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5427 34
Species where no ortholog for SERP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERP1 Gene

ENSEMBL:
Gene Tree for SERP1 (if available)
TreeFam:
Gene Tree for SERP1 (if available)

Paralogs for SERP1 Gene

Paralogs for SERP1 Gene

(1) SIMAP similar genes for SERP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERP1: view

Variants for SERP1 Gene

Sequence variations from dbSNP and Humsavar for SERP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000030094 -- 150,601,650(+) TGGAC(A/C)CTCTC intron-variant, upstream-variant-2KB
rs1000031954 -- 150,554,140(+) ATTCA(C/T)ACCAA intron-variant
rs1000178655 -- 150,576,738(+) GCCAT(G/T)TGGGC intron-variant
rs1000193747 -- 150,575,588(+) ATAAT(-/TTG)TTGTT intron-variant
rs1000305073 -- 150,582,801(+) TGCAT(C/T)ATGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERP1 Gene

Variant ID Type Subtype PubMed ID
nsv511101 OTHER complex 20534489

Variation tolerance for SERP1 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERP1 Gene

Disorders for SERP1 Gene

Relevant External Links for SERP1

Genetic Association Database (GAD)
SERP1
Human Genome Epidemiology (HuGE) Navigator
SERP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERP1

No disorders were found for SERP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERP1 Gene

Publications for SERP1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  5. Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PMID: 10601334) Yamaguchi A. … Tohyama M. (J. Cell Biol. 1999) 2 3 64

Products for SERP1 Gene

Sources for SERP1 Gene

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