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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERP1 Gene

protein-coding GIFtS: 52
GCID: GC03M150259

stress-associated endoplasmic reticulum protein 1

Explore 1 disease affiliated with
SERP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stress-Associated Endoplasmic Reticulum Protein 1¹ ²
RAMP4¹ ² ³
Ribosome-Attached Membrane Protein 4² ³
FLJ43424¹
Ribosome Associated Membrane Protein 4²

External Ids:	HGNC: 10759¹	Entrez Gene: 27230²	Ensembl: ENSG00000120742⁷	UniProtKB: Q9Y6X1³

ORGUL members:
	NONCODE:n384341

Export aliases for SERP1 gene to outside databases

Previous GC identifers: GC03M147184 GC03M151145 GC03M151541 GC03M151581 GC03M151742 GC03M147634

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1

Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target

proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By

similarity)

Gene Wiki entry for SERP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERP1 gene promoter:
CHOP-10 SRY NF-1 AML1a USF-1 USF-1:USF-2 POU3F2 GATA-2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SERP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1

SERP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERP1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M150259: view genomic region (about GC identifiers)

Start:	150,259,780 bp from pter	End:	150,321,015 bp from pter
Size:	61,236 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1 (See protein sequence)

Recommended Name: Stress-associated endoplasmic reticulum protein 1

Size: 66 amino acids; 7374 Da

Subunit: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity)

Subcellular location: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass

membrane protein; Cytoplasmic side (By similarity)

Secondary accessions: D3DNI6

Explore the universe of human proteins at neXtProt for SERP1: NX_Q9Y6X1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6X1

SERP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055260.1

ENSEMBL proteins:

ENSP00000420076 ENSP00000420002 ENSP00000419472 ENSP00000239944

Reactome Protein details: Q9Y6X1
Human Recombinant Protein Products:

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	Novus Biologicals SERP1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SERP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	10601334
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005840	ribosome	TAS	10601334
GO:0016021	integral to membrane	IEA	--

SERP1 for ontologies About GeneDecksing

SERP1 Antibody Products:

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	Novus Biologicals SERP1 Antibody
	Search for Antibodies for SERP1 at Abcam
	Uscn Antibodies for SERP1
	ThermoFisher Antibodies for SERP1

Assay Products for SERP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SERP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR010580 ER_stress-assoc_Ramp4

Graphical View of Domain Structure for InterPro Entry Q9Y6X1

ProtoNet protein and cluster: Q9Y6X1

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1

Similarity: Belongs to the RAMP4 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1

Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target

proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By

similarity)

miRNA Products:		miRTarBase miRNAs that target SERP1: hsa-mir-204 (MIRT005843), hsa-mir-1 (MIRT002806), hsa-mir-124 (MIRT002684), hsa-mir-98 (MIRT004944)

		OriGene 3'-UTR Clone: SERP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERP1
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SERP1 (see all 63):
		hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SERP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERP1 (see all 4) OriGene shRNA RFP: SERP1 OriGene siRNA: SERP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SERP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERP1
		Search LifeMap BioReagents cell lines for SERP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

1 GenomeRNAi human phenotype for SERP1:

Decreased Wnt reporter activit

Animal Models:
Mouse knock-out Serp1^tm1Hori for SERP1
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serp1):

endocrine/exocrine gland	growth/size	homeostasis/metabolism	mortality/aging	muscle
nervous system	skeleton

SERP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of Chaperone Genes by XBP1(S)

	Activation of Chaperone Genes by XBP1(S)	1.00			Unfolded Protein Response	0.71
	Activation of Chaperones by IRE1alpha	0.94

Expression of SERP1 (RAMP4)

Expression of SERP1 (RAMP4)

1.00

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SERP1

	Activation of Chaperone Genes by XBP1(S)
	Expression of SERP1 (RAMP4)
	Metabolism of proteins
	Activation of Chaperones by IRE1alpha
	Unfolded Protein Response

SERP1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SERP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for SERP1 (Q9Y6X1³ ENSP00000239944⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEC61A1	P61619³, ENSP00000243253⁴	I2D: score=1 STRING: ENSP00000243253
ASNA1	O43681³, ENSP00000349887⁴	I2D: score=1 STRING: ENSP00000349887
BAG6	P46379³, ENSP00000365131⁴	I2D: score=1 STRING: ENSP00000365131
CANX	P27824³, ENSP00000247461⁴	I2D: score=2 STRING: ENSP00000247461
DNAJB1	P25685³, ENSP00000254322⁴	I2D: score=1 STRING: ENSP00000254322

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006006	glucose metabolic process	IEA	--
GO:0006464	cellular protein modification process	TAS	10601334
GO:0006486	protein glycosylation	IEA	--
GO:0006950	response to stress	TAS	10601334

SERP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERP1
Search CenterWatch for drugs/clinical trials and news about SERP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERP1 gene:

NM_014445.3

Unigene Cluster for SERP1:

Stress-associated endoplasmic reticulum protein 1

Hs.713956 [show with all ESTs]

Unigene Representative Sequence: AK125413

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479209(uc003exy.3 uc003exz.3) ENST00000487153 ENST00000491660

ENST00000491195 ENST00000490945(uc003eye.2) ENST00000463647 ENST00000484608

ENST00000239944

miRNA Products:		OriGene 3'-UTR Clone: SERP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERP1
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SERP1 (see all 63):
		hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SERP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERP1 (see all 4) OriGene shRNA RFP: SERP1 OriGene siRNA: SERP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP1

Additional cDNA sequence:

AB022427.1 AF136975.1 AK054644.1 AK125413.1 AL136807.1 BC108314.1 BC112364.1 BC112365.1

CR533472.1 X75694.1

24/43 DOTS entries (see all 43):

DT.100879080 DT.450278 DT.100879085 DT.92465017 DT.100879070 DT.100879072 DT.100879083 DT.100879074

DT.95174164 DT.120912583 DT.100771180 DT.100879071 DT.97861026 DT.100879069 DT.120912615 DT.120912454

DT.120912646 DT.100879089 DT.120912456 DT.100879079 DT.120912608 DT.95174136 DT.95174138 DT.100879068

24/1031 AceView cDNA sequences (see all 1031):

BM454726 BU633793 AU130355 BE909005 BM478798 CA421452 AI690572 BF436830

CA393594 R26722 AI272243 AV715079 AI144142 BQ015725 AI131473 BM817975

AA845590 BQ670283 BM916491 AI093889 AW069666 BQ652447 BX448913 AK098135

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SERP1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:							-
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for SERP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See SERP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERP1

SOURCE GeneReport for Unigene cluster: Hs.713956

SABiosciences Expression via Pathway-Focused PCR Arrays including SERP1:

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SERP1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SERP1 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Serp1^{1 , 5}	stress-associated endoplasmic reticulum protein 1^{1, 5}	95.96(n)¹ 100(a)¹		3 (28.58 cM)⁵ 28146¹ NM_030685.3¹ NP_109610.1¹ 58521969⁵
African clawed frog (Xenopus laevis)	Amphibia	Xl.25641²	Xenopus laevis transcribed sequence with weak similarity more	84.06(n)		CA789435.1
zebrafish (Danio rerio)	Actinopterygii	serp1¹	stress-associated endoplasmic reticulum protein 1	74.24(n) 87.88(a)		336797 NM_200034.1 NP_956328.1
fruit fly (Drosophila melanogaster)	Insecta	CG32276⁶	--	67(a)	1 → many	3L(3197863-3199047)
worm (Caenorhabditis elegans)	Secernentea	T09A12.5⁶ F59F4.2⁶	Protein F59F4.2	51(a) 51(a)	many ↔ many many ↔ many	IV(8225662-8226747) X(15841503-15842404)

ENSEMBL Gene Tree for SERP1 (if available)
TreeFam Gene Tree for SERP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERP1 gene

SERP2²

1 SIMAP similar gene for SERP1 using alignment to 3 protein entries: SERP1_HUMAN (see all proteins):

SERP2

SERP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191881688^1,2		--	150259298(+)	`CCATGC/TCCCTT`	1	--	int¹		0	--	--	--	--
rs184387393^1,2		--	150259377(+)	`CTAGCC/TTTTTA`	1	--	int¹		0	--	--	--	--
rs73001321^1,2	C,	--	150259386(+)	`TATTGC/TTCATT`	1	--	int¹		1		WA	2
rs190009359^1,2		--	150259417(+)	`ACATGA/TGTCCT`	1	--	int¹		0	--	--	--	--
rs182394267^1,2		--	150259420(+)	`TGTGTC/GCTAAT`	1	--	int¹		0	--	--	--	--
rs77567250^1,2	C,	--	150259467(+)	`GGTAC-/TAAG TAAGT`	1	--	int¹		0	--	--	--	--
rs60104080^1,2	C	--	150259468(+)	`TAAGT-/AAGT TTAGA`	1	--	int¹		1		NA	2
rs141087529^1,2		--	150259490(+)	`AAATGC/TTTCTC`	1	--	int¹		0	--	--	--	--
rs11922157^1,2	C,F,A,H,	--	150259668(+)	`AAGCAT/CAATAA`	1	--	int¹		23		NS EA NA WA CSA	2350
rs8052^1,2	C,F,O,A,H,	--	150259942(+)	`TAGAGC/TTAAAC`	1	--	ut3¹		36		MN EA NA NS WA CSA	3315

HapMap Linkage Disequilibrium report for SERP1 (150259780 - 150321015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SERP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERP1

DNA2.0 Custom Variant and Variant Library Synthesis for SERP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERP1 for disorders About GeneDecksing

1 disease for SERP1: About MalaCards

cowpox

Human Genome Epidemiology (HuGE) Navigator: SERP1 (3 documents)

Export disorders for SERP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERP1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SERP1)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PubMed id 10601334)^{1, 3} Yamaguchi A....Tohyama M. (1999)
Regulation of ENaC biogenesis by the stress response p rotein SERP1. (PubMed id 22526458)¹ Faria D....Kunzelmann K. (2012)
SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. (PubMed id 22419128)¹ Atschekzei F....Serth J. (2012)
HIV-1 Tat protein promotes neuronal dysfunction throug h disruption of microRNAs. (PubMed id 21956116)¹ Chang J.R....Sawaya B.E. (2011)
Deregulation of microRNAs by HIV-1 Vpr protein leads t o the development of neurocognitive disorders. (PubMed id 21816823)¹ Mukerjee R....Sawaya B.E. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Bat3 promotes the membrane integration of tail-anchor ed proteins. (PubMed id 20516149)¹ Leznicki P....High S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27230	HGNC: 10759	AceView: SERP1	Ensembl:ENSG00000120742	euGenes: HUgn27230
ECgene: SERP1	H-InvDB: SERP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SERP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SERP1 gene:
Search GeneIP for patents involving SERP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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SERP1 Gene

stress-associated endoplasmic reticulum protein 1

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SERP1 Gene

stress-associated endoplasmic reticulum protein 1

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