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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERP1 Gene

protein-coding   GIFtS: 53
GCID: GC03M150259

Stress-Associated Endoplasmic Reticulum Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stress-Associated Endoplasmic Reticulum Protein 11 2
Ribosome Associated Membrane Protein 41 2
Ribosome-Attached Membrane Protein 42 3
RAMP42 3

External Ids:    HGNC: 107591   Entrez Gene: 272302   Ensembl: ENSG000001207427   UniProtKB: Q9Y6X13   
ORGUL members:         
NONCODE14:n384341      

Export aliases for SERP1 gene to outside databases

Previous GC identifers: GC03M147184 GC03M151145 GC03M151541 GC03M151581 GC03M151742 GC03M147634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERP1 Gene: 
SERP1 (stress-associated endoplasmic reticulum protein 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SERP1 include cowpox, and neuronitis, and among its related super-pathways are Activation of Chaperones by IRE1alpha and Post-translational protein modification. An important paralog of this gene is SERP2.

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1
Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.
Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target
proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By
similarity)

Gene Wiki entry for SERP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERP1 gene promoter:
         CHOP-10   SRY   NF-1   AML1a   USF-1   USF-1:USF-2   POU3F2   GATA-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

SERP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M150259:  view genomic region     (about GC identifiers)

Start:
150,259,780 bp from pter      End:
150,321,015 bp from pter
Size:
61,236 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1 (See protein sequence)
Recommended Name: Stress-associated endoplasmic reticulum protein 1  
Size: 66 amino acids; 7374 Da
Subunit: Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity)
Subcellular location: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass
membrane protein; Cytoplasmic side (By similarity)
Secondary accessions: D3DNI6

Explore the universe of human proteins at neXtProt for SERP1: NX_Q9Y6X1

Explore proteomics data for SERP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6X1

  • SERP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERP1 Protein Expression
    REFSEQ proteins: NP_055260.1  
    ENSEMBL proteins: 
     ENSP00000420076   ENSP00000420002   ENSP00000419472   ENSP00000239944  
    Reactome Protein details: Q9Y6X1
    Human Recombinant Protein Products for SERP1: 
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    OriGene Protein Over-expression Lysate for SERP1
    OriGene MassSpec for SERP1 
    OriGene Custom Protein Services for SERP1
    GenScript Custom Purified and Recombinant Proteins Services for SERP1
    Novus Biologicals SERP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS10601334
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005840ribosome TAS10601334
    GO:0005881cytoplasmic microtubule IDA--
    GO:0016021integral to membrane IEA--

    SERP1 for ontologies           About GeneDecksing



    SERP1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SERP1 

    Assay Products for SERP1: 
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    Cloud-Clone Corp. ELISAs for SERP1 
    Cloud-Clone Corp. CLIAs for SERP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010580 ER_stress-assoc_Ramp4

    Graphical View of Domain Structure for InterPro Entry Q9Y6X1

    ProtoNet protein and cluster: Q9Y6X1

    UniProtKB/Swiss-Prot: SERP1_HUMAN, Q9Y6X1
    Similarity: Belongs to the RAMP4 family


    SERP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERP1_HUMAN, Q9Y6X1
    Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.
    Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target
    proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By
    similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for SERP1:

     Decreased Wnt reporter activit 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Serp1):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  skeleton 

    SERP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Serp1tm1Hori for SERP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERP1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERP1:
    hsa-mir-204 (MIRT005843), hsa-mir-1 (MIRT002806), hsa-mir-124 (MIRT002684), hsa-mir-98 (MIRT004944)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERP1
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SERP1 (see all 63):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSERP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for SERP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of SERP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SERP1
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response



    SERP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/16 Interacting proteins for SERP1 (Q9Y6X13 ENSP000002399444) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793, ENSP000003651314I2D: score=1 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    ENSG00000228760P463793I2D: score=1 
    ENSG00000229524P463793I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0006464cellular protein modification process TAS10601334
    GO:0006486protein glycosylation IEA--
    GO:0006950response to stress TAS10601334

    SERP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERP1

    Search CenterWatch for drugs/clinical trials and news about SERP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERP1 gene: 
    NM_014445.3  

    Unigene Cluster for SERP1:

    Stress-associated endoplasmic reticulum protein 1
    Hs.713956  [show with all ESTs]
    Unigene Representative Sequence: AK125413
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479209(uc003exy.3 uc003exz.3) ENST00000487153 ENST00000491660
    ENST00000491195 ENST00000490945(uc003eye.2) ENST00000463647 ENST00000484608
    ENST00000239944
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERP1
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SERP1 (see all 63):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSERP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERP1
    Clone
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    OriGene clones in human, mouse for SERP1 (see all 7)
    OriGene ORF clones in mouse, rat for SERP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1
    Sirion Biotech Customized lentivirus for stable overexpression of SERP1 
                         Customized lentivirus expression plasmids for stable overexpression of SERP1 
    Primer
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    OriGene qPCR primer pairs and template standards for SERP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP1

    Additional mRNA sequence: 

    AB022427.1 AF136975.1 AK054644.1 AK125413.1 AL136807.1 BC108314.1 BC112364.1 BC112365.1 
    CR533472.1 X75694.1 

    24/43 DOTS entries (see all 43):

    DT.100879080  DT.450278  DT.100879085  DT.92465017  DT.100879070  DT.100879072  DT.100879083  DT.100879074 
    DT.95174164  DT.120912583  DT.100771180  DT.100879071  DT.97861026  DT.100879069  DT.120912615  DT.120912454 
    DT.120912646  DT.100879089  DT.120912456  DT.100879079  DT.120912608  DT.95174136  DT.95174138  DT.100879068 

    24/1031 AceView cDNA sequences (see all 1031):

    BQ645251 CR594954 CA450200 AA812061 AA767090 BG939870 AI143541 BM989391 
    BU508378 CA392188 AA805273 BM557249 AA557636 AI378240 BM968138 BF939785 
    AA085757 AA815046 AA922012 AA766352 CB156528 BM833230 BG942527 AA482516 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SERP1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                    -               
    SP2:                                    
    SP3:              -     -               


    ECgene alternative splicing isoforms for SERP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERP1 Expression
    About this image


    See SERP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERP1

    SOURCE GeneReport for Unigene cluster: Hs.713956
        SABiosciences Expression via Pathway-Focused PCR Arrays including SERP1: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SERP1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serp11 , 5 stress-associated endoplasmic reticulum protein 11, 5 95.96(n)1
    100(a)1
      3 (28.58 cM)5
    281461  NM_030685.31  NP_109610.11 
     585219695 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256412 Xenopus laevis transcribed sequence with weak similarity more 84.06(n)    CA789435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii serp11 stress-associated endoplasmic reticulum protein 1 74.24(n)
    87.88(a)
      336797  NM_200034.1  NP_956328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322766
    --
    67(a)
    1 → many
    3L(3197863-3199047)
    worm
    (Caenorhabditis elegans)
    Secernentea T09A12.56
    F59F4.26
    Protein F59F4.2
    52(a)
    51(a)
    many ↔ many
    many ↔ many
    IV(8225676-8226761)
    X(15841572-15842473)


    ENSEMBL Gene Tree for SERP1 (if available)
    TreeFam Gene Tree for SERP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERP1 gene
    SERP22  
    1 SIMAP similar gene for SERP1 using alignment to 3 protein entries:     SERP1_HUMAN (see all proteins):
    SERP2

    SERP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 SNPs in SERP1 are shown (see all 66)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918816881,2
    --150259298(+) CCATGC/TCCCTT 1 -- int10--------
    rs1843873931,2
    --150259377(+) CTAGCC/TTTTTA 1 -- int10--------
    rs730013211,2
    C--150259386(+) TATTGC/TTCATT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1900093591,2
    --150259417(+) ACATGA/TGTCCT 1 -- int10--------
    rs1823942671,2
    --150259420(+) TGTGTC/GCTAAT 1 -- int10--------
    rs775672501,2
    C--150259467(+) GGTAC-/TAAG  
            
    TAAGT
    1 -- int10--------
    rs601040801,2
    C--150259468(+) TAAGT-/AAGT  
            
    TTAGA
    1 -- int11Minor allele frequency- AAGT:0.00NA 2
    rs1410875291,2
    C--150259490(+) AAATGC/TTTCTC 1 -- int10--------
    rs119221571,2
    C,F,A,H--150259668(+) AAGCAT/CAATAA 1 -- int123Minor allele frequency- C:0.46NS EA NA WA CSA 2350
    rs80521,2
    C,F,O,A,H--150259942(+) TAGAGC/TTAAAC 1 -- ut3136Minor allele frequency- T:0.22MN EA NA NS WA CSA 3315

    HapMap Linkage Disequilibrium report for SERP1 (150259780 - 150321015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SERP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv511101CNV Complex20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SERP1:    About MalaCards
    cowpox    neuronitis


    SERP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERP1
    Human Genome Epidemiology (HuGE) Navigator: SERP1 (3 documents)

    Export disorders for SERP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERP1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SERP1)
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    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    5. Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PubMed id 10601334)1, 3 Yamaguchi A....Tohyama M. (1999)
    6. Regulation of ENaC biogenesis by the stress response p rotein SERP1. (PubMed id 22526458)1 Faria D....Kunzelmann K. (2012)
    7. SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. (PubMed id 22419128)1 Atschekzei F....Serth J. (2012)
    8. HIV-1 Tat protein promotes neuronal dysfunction throug h disruption of microRNAs. (PubMed id 21956116)1 Chang J.R....Sawaya B.E. (2011)
    9. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)
    10. Deregulation of microRNAs by HIV-1 Vpr protein leads t o the development of neurocognitive disorders. (PubMed id 21816823)1 Mukerjee R....Sawaya B.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27230 HGNC: 10759 AceView: SERP1 Ensembl:ENSG00000120742 euGenes: HUgn27230
    ECgene: SERP1 H-InvDB: SERP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERP1 gene:
    Search GeneIP for patents involving SERP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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