SERP1 Gene

Aliases
for SERP1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC03M147184 GC03M151145 GC03M151541 GC03M151581 GC03M151742 GC03M147634

Summaries
for SERP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for SERP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

SwitchGear Promoter luciferase reporter plasmid: SERP1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERP1

SERP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M150259:  view genomic region     (about GC identifiers)

Proteins
for SERP1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for SERP1: NX_Q9Y6X1

Explore proteomics data for SERP1 at MOPED

Post-translational modifications: 

SERP1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SERP1 OriGene Protein Over-expression Lysate for SERP1 OriGene MassSpec for SERP1 OriGene Custom Protein Services for SERP1
	GenScript Custom Purified and Recombinant Proteins Services for SERP1
	Novus Biologicals SERP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SERP1
	Search eBioscience for Proteins for SERP1
	Search GeneTex for Proteins for SERP1
	Search antibodies-online for proteins for SERP1
	antibodies-online peptides for SERP1

SERP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for SERP1 OriGene Custom Antibody Services for SERP1
	Novus Biologicals SERP1 Antibody
	Abcam antibodies for SERP1
	Cloud-Clone Corp. Antibodies for SERP1
	ThermoFisher Antibodies for SERP1
	antibodies-online antibodies for SERP1 (10 products)

SERP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SERP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SERP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SERP1 Cloud-Clone Corp. CLIAs for SERP1
	Search eBioscience for ELISAs for SERP1
	antibodies-online kits for SERP1 (9 products)

Domains /
Families
for SERP1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9Y6X1

Find genes that share domains with SERP1           About GenesLikeMe

Function
for SERP1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for SERP1:

(inferred from 1 allele) (MGI details for Serp1)

genOway: Develop your customized and physiologically relevant rodent model for SERP1

miRNA Products:		miRTarBase miRNAs that target SERP1: hsa-mir-7-5p (MIRT025860), hsa-mir-1 (MIRT002806), hsa-mir-124-3p (MIRT002684), hsa-mir-744-5p (MIRT037576), hsa-mir-204-5p (MIRT005843), hsa-mir-186-5p (MIRT044942), hsa-mir-98-5p (MIRT004944), hsa-mir-375 (MIRT019926)
		Block miRNA regulation of human, mouse, rat SERP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SERP1 (see all 63):
		hsa-miR-142-5p hsa-miR-562 hsa-miR-106a hsa-miR-513a-5p hsa-miR-218 hsa-miR-890 hsa-miR-124 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: SERP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SERP1
		Predesigned siRNA for gene silencing in human, mouse, rat SERP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SERP1

Clone Products:		OriGene clones in human, mouse for SERP1 (see all 6) OriGene ORF clones in mouse, rat for SERP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERP1 (NM_014445)
		Sino Biological Human cDNA Clone for SERP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERP1
		Addgene plasmids for SERP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for SERP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

Localization
for SERP1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	5
endoplasmic reticulum	5
extracellular	2
mitochondrion	2
cytosol	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for SERP1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for SERP1 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Unfolded Protein Response	Unfolded Protein Response 0.61 Activation of Chaperone Genes by XBP1(S) 0.59 Activation of Chaperones by IRE1alpha 0.61
2	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Metabolism of proteins 0.30

1 Reactome Pathway for SERP1

XBP1(S) activates chaperone genes

Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

Drugs & Compounds
for SERP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for SERP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for SERP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for SERP1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERP1
		QuantiTect SYBR Green Assays in human, mouse, rat SERP1
		QuantiFast Probe-based Assays in human, mouse, rat SERP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERP1

Orthologs
for SERP1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for SERP1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SERP1 gene

SERP2²  

1 SIMAP similar gene for SERP1 using alignment to 3 protein entries:     SERP1_HUMAN (see all proteins):

SERP2

Find genes that share paralogs with SERP1           About GenesLikeMe

Genomic Variants
for SERP1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for SERP1 (see all 66)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1918816881,2		--	150259298(+)	CCATGC/TCCCTT	1	--	int1		0	--	--	--	--
rs1843873931,2		--	150259377(+)	CTAGCC/TTTTTA	1	--	int1		0	--	--	--	--
rs730013211,2	C	--	150259386(+)	TATTGC/TTCATT	1	--	int1		1		WA	2
rs1900093591,2		--	150259417(+)	ACATGA/TGTCCT	1	--	int1		0	--	--	--	--
rs1823942671,2		--	150259420(+)	TGTGTC/GCTAAT	1	--	int1		0	--	--	--	--
rs775672501,2	C	--	150259467(+)	GGTAC-/TAAG           TAAGT	1	--	int1		0	--	--	--	--
rs601040801,2	C	--	150259468(+)	TAAGT-/AAGT           TTAGA	1	--	int1		1		NA	2
rs1410875291,2	C	--	150259490(+)	AAATGC/TTTCTC	1	--	int1		0	--	--	--	--
rs119221571,2	C,F,A,H	--	150259668(+)	AAGCAT/CAATAA	1	--	int1		23		NS EA NA WA CSA	2350
rs80521,2	C,F,O,A,H	--	150259942(+)	TAGAGC/TTAAAC	1	--	ut31		36		MN EA NA NS WA CSA	3315

HapMap Linkage Disequilibrium report for SERP1 (150259780 - 150321015 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SERP1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv511101	CNV	Complex	20534489

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SERP1

DNA2.0 Custom Variant and Variant Library Synthesis for SERP1

Disorders / Diseases
for SERP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for SERP1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (Genome Res. 2001)
2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
5. Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. (PubMed id 10601334)^{1, 3} Yamaguchi A....Tohyama M. (J. Cell Biol. 1999)
6. Regulation of ENaC biogenesis by the stress response protein SERP1. (PubMed id 22526458)¹ Faria D....Kunzelmann K. (Pflugers Arch. 2012)
7. SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence. (PubMed id 22419128)¹ Atschekzei F....Serth J. (Epigenetics 2012)
8. HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. (PubMed id 21956116)¹ Chang J.R....Sawaya B.E. (J. Biol. Chem. 2011)
9. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)¹ Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
10. Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. (PubMed id 21816823)¹ Mukerjee R....Sawaya B.E. (J. Biol. Chem. 2011)

External Searches for SERP1 gene

Genome Databases showing SERP1 gene

Other Databases showing SERP1 gene

Specialized Databases showing SERP1 gene

Products
for SERP1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section