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Aliases for SERINC5 Gene

Aliases for SERINC5 Gene

  • Serine Incorporator 5 2 3 5
  • C5orf12 3 4
  • Chromosome 5 Open Reading Frame 12 2
  • TPO1 3

External Ids for SERINC5 Gene

Previous HGNC Symbols for SERINC5 Gene

  • C5orf12

Previous GeneCards Identifiers for SERINC5 Gene

  • GC05M079479
  • GC05M074614
  • GC05M079407

Summaries for SERINC5 Gene

GeneCards Summary for SERINC5 Gene

SERINC5 (Serine Incorporator 5) is a Protein Coding gene. Diseases associated with SERINC5 include Hiv-1. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot for SERINC5 Gene

  • Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC5 Gene

Genomics for SERINC5 Gene

Regulatory Elements for SERINC5 Gene

Enhancers for SERINC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F080133 1.1 Ensembl ENCODE 22.7 +117.7 117708 10.7 ELF3 ZNF133 ARID4B RAD21 RARA ETV6 MIXL1 CEBPB JUNB KAT8 SERINC5 CTD-2201I18.1 THBS4 GC05M080138 ENSG00000251675
GH05F080210 1.3 FANTOM5 Ensembl ENCODE 20.9 +41.0 40982 9.4 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RPS3AP20 SERINC5 PAPD4 JMY MSH3 ENSG00000251675 CTD-2201I18.1 THBS4 DHFR GC05P080147
GH05F080228 1.3 Ensembl ENCODE 20.5 +25.5 25529 3.1 ELF3 MLX THRB ZSCAN9 RARA KAT2B YY1 ZNF121 FOS CREM SERINC5 ENSG00000251675 CTD-2201I18.1 THBS4 GC05P080147
GH05F080203 1.4 Ensembl ENCODE 19.6 +50.5 50456 3.8 PKNOX1 ARNT MLX ARID4B YY1 SP5 REST SMARCB1 KAT8 MEF2D SERINC5 RPS3AP20 JMY MSH3 ENSG00000251675 GC05P080147
GH05F080179 1.5 FANTOM5 Ensembl ENCODE 18.8 +68.2 68227 17.2 PKNOX1 ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP5 ZHX2 TBX21 SERINC5 PAPD4 ENSG00000251675 JMY CTD-2201I18.1 THBS4 DHFR LINC01337 GC05P080147
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERINC5 on UCSC Golden Path with GeneCards custom track

Promoters for SERINC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001283957 182 3801 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 FOS ZNF263 SP3 SP5

Genomic Location for SERINC5 Gene

Chromosome:
5
Start:
80,111,227 bp from pter
End:
80,256,082 bp from pter
Size:
144,856 bases
Orientation:
Minus strand

Genomic View for SERINC5 Gene

Genes around SERINC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC5 Gene

Proteins for SERINC5 Gene

  • Protein details for SERINC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VE9-SERC5_HUMAN
    Recommended name:
    Serine incorporator 5
    Protein Accession:
    Q86VE9
    Secondary Accessions:
    • B4DMH7
    • Q495A4
    • Q495A6

    Protein attributes for SERINC5 Gene

    Size:
    423 amino acids
    Molecular mass:
    47009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC5 Gene

Post-translational modifications for SERINC5 Gene

  • Ubiquitination at Lys 373
  • Glycosylation at Asn 113 and Asn 183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SERINC5 Gene

Domains & Families for SERINC5 Gene

Protein Domains for SERINC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERINC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VE9

UniProtKB/Swiss-Prot:

SERC5_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC5: view

No data available for Gene Families for SERINC5 Gene

Function for SERINC5 Gene

Molecular function for SERINC5 Gene

UniProtKB/Swiss-Prot Function:
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with SERINC5: view

Phenotypes for SERINC5 Gene

genes like me logo Genes that share phenotypes with SERINC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC5 Gene

Localization for SERINC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC5 Gene

Cell membrane; Multi-pass membrane protein.
Cytoplasm, perinuclear region. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (PubMed:26416733, PubMed:26416734). Localizes to the cell membrane, where it is efficiently incorporated into budding virions and impairs subsequent virion entry into target cells (PubMed:26416733, PubMed:26416734). {ECO:0000269 PubMed:26416734, ECO:0000305 PubMed:26416733}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERINC5 Gene COMPARTMENTS Subcellular localization image for SERINC5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA,IDA 26416733
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SERINC5: view

Pathways & Interactions for SERINC5 Gene

genes like me logo Genes that share pathways with SERINC5: view

Interacting Proteins for SERINC5 Gene

Gene Ontology (GO) - Biological Process for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006658 phosphatidylserine metabolic process IEA,ISS --
GO:0006665 sphingolipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0009597 detection of virus IDA 26416733
genes like me logo Genes that share ontologies with SERINC5: view

No data available for SIGNOR curated interactions for SERINC5 Gene

Drugs & Compounds for SERINC5 Gene

(124) Additional Compounds for SERINC5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC5: view

Transcripts for SERINC5 Gene

Unigene Clusters for SERINC5 Gene

Serine incorporator 5:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for SERINC5 Gene

GeneLoc Exon Structure for
SERINC5
ECgene alternative splicing isoforms for
SERINC5

Expression for SERINC5 Gene

mRNA expression in normal human tissues for SERINC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC5 Gene

This gene is overexpressed in Retina (15.1), Ovary (10.4), Spinal cord (8.0), and Prostate (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERINC5 Gene



Protein tissue co-expression partners for SERINC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERINC5 Gene:

SERINC5

SOURCE GeneReport for Unigene cluster for SERINC5 Gene:

Hs.288232

mRNA Expression by UniProt/SwissProt for SERINC5 Gene:

Q86VE9-SERC5_HUMAN
Tissue specificity: Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.
genes like me logo Genes that share expression patterns with SERINC5: view

Primer Products

No data available for mRNA differential expression in normal tissues for SERINC5 Gene

Orthologs for SERINC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC5 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia SERINC5 34 35
  • 87.64 (n)
cow
(Bos Taurus)
Mammalia SERINC5 34 35
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Serinc5 34 16 35
  • 82.54 (n)
rat
(Rattus norvegicus)
Mammalia Serinc5 34
  • 82.32 (n)
oppossum
(Monodelphis domestica)
Mammalia SERINC5 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC5 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC5 34 35
  • 73.75 (n)
lizard
(Anolis carolinensis)
Reptilia SERINC5 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc5 34
  • 68.26 (n)
Str.11510 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7097 34
zebrafish
(Danio rerio)
Actinopterygii serinc5 34 35
  • 64.4 (n)
Dr.7467 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.659 34
fruit fly
(Drosophila melanogaster)
Insecta TMS1 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 35
  • 37 (a)
ManyToMany
Y57E12AL.1 35
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5552 34
Species where no ortholog for SERINC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC5 Gene

ENSEMBL:
Gene Tree for SERINC5 (if available)
TreeFam:
Gene Tree for SERINC5 (if available)

Paralogs for SERINC5 Gene

Paralogs for SERINC5 Gene

(6) SIMAP similar genes for SERINC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SERINC5: view

Variants for SERINC5 Gene

Sequence variations from dbSNP and Humsavar for SERINC5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035380 -- 80,172,074(+) TGCCT(A/G)TAATC intron-variant
rs10035618 -- 80,197,327(+) AGAGA(A/C/G)AGAGA intron-variant
rs10036141 -- 80,200,651(+) CACTG(C/T)AGTAT intron-variant
rs10036776 -- 80,214,155(+) AAGAC(A/G)TCCAC intron-variant
rs10036779 -- 80,214,173(+) aaact(A/G)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC5 Gene

Variant ID Type Subtype PubMed ID
dgv1108e214 CNV gain 21293372
esv2677189 CNV deletion 23128226
esv2678473 CNV deletion 23128226
esv2730364 CNV deletion 23290073
esv3416558 CNV insertion 20981092
esv3605549 CNV loss 21293372
esv3605550 CNV loss 21293372
esv3605551 CNV loss 21293372
esv3605552 CNV gain 21293372
esv3605553 CNV loss 21293372
esv3605554 CNV loss 21293372
esv3605555 CNV gain 21293372
esv3605556 CNV loss 21293372
esv3605560 CNV loss 21293372
esv3605561 CNV loss 21293372
esv3605562 CNV loss 21293372
esv3605563 CNV loss 21293372
esv3605564 CNV loss 21293372
nsv516093 CNV loss 19592680
nsv598744 CNV gain 21841781

Variation tolerance for SERINC5 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC5 Gene

Disorders for SERINC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERINC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERINC5

Genetic Association Database (GAD)
SERINC5
Human Genome Epidemiology (HuGE) Navigator
SERINC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC5
genes like me logo Genes that share disorders with SERINC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERINC5 Gene

Publications for SERINC5 Gene

  1. Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family. (PMID: 12688535) Xu J. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4 64
  2. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. (PMID: 26416733) Usami Y. … GAPttlinger H.G. (Nature 2015) 3 4 64
  3. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. (PMID: 26416734) Rosa A. … Pizzato M. (Nature 2015) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. (PMID: 26439863) Matheson N.J. … Lehner P.J. (Cell Host Microbe 2015) 3 64

Products for SERINC5 Gene

Sources for SERINC5 Gene

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