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Aliases for SERINC5 Gene

Aliases for SERINC5 Gene

  • Serine Incorporator 5 2 3
  • C5orf12 3 4 6
  • TPO1 3 6
  • Chromosome 5 Open Reading Frame 12 2

External Ids for SERINC5 Gene

Previous Symbols for SERINC5 Gene

  • C5orf12

Summaries for SERINC5 Gene

GeneCards Summary for SERINC5 Gene

SERINC5 (Serine Incorporator 5) is a Protein Coding gene. An important paralog of this gene is SERINC2.

UniProtKB/Swiss-Prot for SERINC5 Gene

  • Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC5 Gene

Genomics for SERINC5 Gene

Genomic Location for SERINC5 Gene

80,111,227 bp from pter
80,256,079 bp from pter
144,853 bases
Minus strand

Genomic View for SERINC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERINC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC5 Gene

Regulatory Elements for SERINC5 Gene

Proteins for SERINC5 Gene

  • Protein details for SERINC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine incorporator 5
    Protein Accession:
    Secondary Accessions:
    • B4DMH7
    • Q495A4
    • Q495A6

    Protein attributes for SERINC5 Gene

    423 amino acids
    Molecular mass:
    47009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC5 Gene


neXtProt entry for SERINC5 Gene

Proteomics data for SERINC5 Gene at MOPED

Post-translational modifications for SERINC5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys373
  • Glycosylation at Asn113 and Asn183

Other Protein References for SERINC5 Gene

No data available for DME Specific Peptides for SERINC5 Gene

Domains for SERINC5 Gene

Protein Domains for SERINC5 Gene



  • Belongs to the TDE1 family.:
    • Q86VE9
genes like me logo Genes that share domains with SERINC5: view

No data available for Gene Families for SERINC5 Gene

Function for SERINC5 Gene

Molecular function for SERINC5 Gene

UniProtKB/Swiss-Prot Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC5: view

miRNA for SERINC5 Gene

miRTarBase miRNAs that target SERINC5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERINC5 Gene

Localization for SERINC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SERINC5 Gene COMPARTMENTS Subcellular localization image for SERINC5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SERINC5: view

Pathways for SERINC5 Gene

SuperPathways for SERINC5 Gene

No Data Available

Interacting Proteins for SERINC5 Gene

Gene Ontology (GO) - Biological Process for SERINC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process ISS --
GO:0006665 sphingolipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0015825 L-serine transport IBA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with SERINC5: view

No data available for Pathways by source for SERINC5 Gene

Compounds for SERINC5 Gene

(124) HMDB Compounds for SERINC5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Phosphatidylserine(14:0/14:0)
Not Available
  • Phosphatidylserine(14:0/14:1n5)
Not Available
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
  • PS(14:0/16:1n7)
Not Available
  • Phosphatidylserine(32:0)
Not Available
genes like me logo Genes that share compounds with SERINC5: view

Transcripts for SERINC5 Gene

Unigene Clusters for SERINC5 Gene

Serine incorporator 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -

Relevant External Links for SERINC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERINC5 Gene

mRNA expression in normal human tissues for SERINC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SERINC5 Gene

SOURCE GeneReport for Unigene cluster for SERINC5 Gene Hs.288232

mRNA Expression by UniProt/SwissProt for SERINC5 Gene

Tissue specificity: Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.
genes like me logo Genes that share expressions with SERINC5: view

Orthologs for SERINC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERINC5 36
  • 99.42 (n)
  • 99.78 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SERINC5 36
  • 86.27 (n)
  • 86.06 (a)
  • 85 (a)
(Canis familiaris)
Mammalia SERINC5 36
  • 87.64 (n)
  • 89.59 (a)
  • 90 (a)
(Mus musculus)
Mammalia Serinc5 36
  • 82.54 (n)
  • 81.96 (a)
Serinc5 16
Serinc5 37
  • 82 (a)
(Monodelphis domestica)
Mammalia SERINC5 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SERINC5 37
  • 70 (a)
(Rattus norvegicus)
Mammalia Serinc5 36
  • 82.32 (n)
  • 82.39 (a)
(Gallus gallus)
Aves SERINC5 36
  • 73.75 (n)
  • 76.36 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia SERINC5 37
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7097 36
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc5 36
  • 68.26 (n)
  • 71.37 (a)
Str.11510 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.659 36
(Danio rerio)
Actinopterygii Dr.7467 36
serinc5 36
  • 64.4 (n)
  • 61.18 (a)
serinc5 37
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 37
  • 33 (a)
(Caenorhabditis elegans)
Secernentea R11H6.2 37
  • 37 (a)
Y57E12AL.1 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 37
  • 26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5552 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
Species with no ortholog for SERINC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC5 Gene

Gene Tree for SERINC5 (if available)
Gene Tree for SERINC5 (if available)

Paralogs for SERINC5 Gene

Paralogs for SERINC5 Gene

Selected SIMAP similar genes for SERINC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SERINC5: view

Variants for SERINC5 Gene

Sequence variations from dbSNP and Humsavar for SERINC5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs173949 -- 80,111,966(+) tcatc(A/C/G/T)ccatt intron-variant
rs256434 -- 80,112,645(+) aaacc(A/G)cccct intron-variant
rs390292 -- 80,119,763(+) CCAGA(C/G)AGCTT intron-variant
rs413411 -- 80,133,507(-) tgtac(A/G)ttatc intron-variant
rs439274 -- 80,122,553(-) AGGTt(A/G)tgatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC5 Gene

Variant ID Type Subtype PubMed ID
esv2678473 CNV Deletion 23128226
nsv516093 CNV Loss 19592680
esv2730364 CNV Deletion 23290073
esv2677189 CNV Deletion 23128226

Relevant External Links for SERINC5 Gene

HapMap Linkage Disequilibrium report

Disorders for SERINC5 Gene

Relevant External Links for SERINC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SERINC5: view

No data available for UniProtKB/Swiss-Prot for SERINC5 Gene

Publications for SERINC5 Gene

  1. Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family. (PMID: 12688535) Xu J. … Mao Y. (Mol. Biol. Rep. 2003) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Genome-wide analyses of borderline personality features. (PMID: 23979607) Lubke G.H. … Boomsma D.I. (Mol. Psychiatry 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for SERINC5 Gene

Sources for SERINC5 Gene

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