Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SERINC5 Gene

protein-coding   GIFtS: 46
GCID: GC05M079407

Serine Incorporator 5

(Previous name: chromosome 5 open reading frame 12)
(Previous symbol: C5orf12)
  Search for SERINC5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine Incorporator 51 2
C5orf121 2 3 5
TPO12 5
Chromosome 5 Open Reading Frame 121

External Ids:    HGNC: 188251   Entrez Gene: 2569872   Ensembl: ENSG000001643007   OMIM: 6145515   UniProtKB: Q86VE93   

Export aliases for SERINC5 gene to outside databases

Previous GC identifers: GC05M079479 GC05M074614


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SERINC5 Gene:
SERINC5 (serine incorporator 5) is a protein-coding gene. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in
providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERINC5 gene promoter:
         STAT1   AML1a   MyoD   RelA   LUN-1   AREB6   Ik-2   NRF-2   STAT3   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERINC5 promoter sequence
   Search Chromatin IP Primers for SERINC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERINC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

SERINC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M079407:  view genomic region     (about GC identifiers)

Start:
79,407,050 bp from pter      End:
79,551,898 bp from pter
Size:
144,849 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9 (See protein sequence)
Recommended Name: Serine incorporator 5  
Size: 423 amino acids; 47009 Da
Secondary accessions: B4DMH7 Q495A4 Q495A6
Alternative splicing: 4 isoforms:  Q86VE9-1   Q86VE9-2   Q86VE9-3   Q86VE9-4   

Explore the universe of human proteins at neXtProt for SERINC5: NX_Q86VE9

Explore proteomics data for SERINC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys373
  • Glycosylation2 at Asn113, Asn183
  • Modification sites at PhosphoSitePlus

  • See SERINC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167542.1  NP_001167543.1  NP_840060.1  

    ENSEMBL proteins: 
     ENSP00000426134   ENSP00000421665   ENSP00000420863   ENSP00000426237  

    SERINC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SERINC5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SERINC5
    GenScript Custom Purified and Recombinant Proteins Services for SERINC5
    Novus Biologicals SERINC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERINC5

    SERINC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SERINC5
    Novus Biologicals SERINC5 Antibody
    Search for Antibodies for SERINC5 at Abcam
    Cloud-Clone Corp. Antibodies for SERINC5
    Search ThermoFisher Antibodies for SERINC5
    Search LSBio for Antibodies for SERINC5

    SERINC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERINC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERINC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SERINC5
    Cloud-Clone Corp. CLIAs for SERINC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR005016 TMS_TDE

    Graphical View of Domain Structure for InterPro Entry Q86VE9

    ProtoNet protein and cluster: Q86VE9

    UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
    Similarity: Belongs to the TDE1 family


    SERINC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERC5_HUMAN, Q86VE9
    Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in
    providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERINC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERINC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERINC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERINC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERINC5:
    hsa-mir-16-5p (MIRT051076), hsa-mir-145-5p (MIRT021507)

    Block miRNA regulation of human, mouse, rat SERINC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERINC5 (see all 67):
    hsa-miR-548j hsa-miR-607 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-548a-5p hsa-miR-761 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERINC5
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERINC5

    Clone
    Products:
         
    OriGene clones in human, mouse for SERINC5 (see all 15)
    OriGene ORF clones in mouse, rat for SERINC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SERINC5 (NM_001174071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERINC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for SERINC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SERC5_HUMAN, Q86VE9: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043209myelin sheath IEA--

    SERINC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERINC5
    Interactions:

        Search GeneGlobe Interaction Network for SERINC5

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006658phosphatidylserine metabolic process ISS--
    GO:0008654phospholipid biosynthetic process IEA--
    GO:0042552myelination IEA--
    GO:0051347positive regulation of transferase activity ISS--

    SERINC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERINC5 (SERC5)

    Selected HMDB Compounds for SERINC5 (see all 124)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----
    PS(14:0/20:4(5Z,8Z,11Z,14Z))PS(34:4) (see all 13)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SERINC5 gene (3 alternative transcripts): 
    NM_001174071.1  NM_001174072.1  NM_178276.5  

    Unigene Cluster for SERINC5:

    Serine incorporator 5
    Hs.288232  [show with all ESTs]
    Unigene Representative Sequence: NM_001174072
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509193 ENST00000512972 ENST00000512721(uc011ctj.2) ENST00000502747
    ENST00000513907 ENST00000507668(uc003kgj.3 uc003kgm.3 uc003kgk.3 uc003kgl.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERINC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERINC5 (see all 67):
    hsa-miR-548j hsa-miR-607 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-548a-5p hsa-miR-761 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERINC5
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC5
    Clone
    Products:
         
    OriGene clones in human, mouse for SERINC5 (see all 15)
    OriGene ORF clones in mouse, rat for SERINC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SERINC5 (NM_001174071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC5
      QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
      QuantiFast Probe-based Assays in human, mouse, rat SERINC5

    Additional mRNA sequence: 

    AF147384.1 AF498273.1 AK026295.1 AK297467.1 BC101280.2 BC101282.3 BC101283.2 CR936687.1 

    15 DOTS entries:

    DT.454633  DT.40131336  DT.91744342  DT.95181134  DT.40235451  DT.306770  DT.306771  DT.40283117 
    DT.120826868  DT.120826889  DT.92030462  DT.104351  DT.120826816  DT.91828401  DT.91911938 

    Selected AceView cDNA sequences (see all 47):

    BM126283 BM709599 BX509349 T96036 BM055085 BM055143 T96046 BM055374 
    CB266037 AI356352 BF057229 N22401 NM_178276 AI873914 BF062191 BI493649 
    AF498273 BX957061 BI857596 AA651940 AA306511 AI075265 BU733615 AI763386 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SERINC5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                 -                                 
    SP2:                    -                 -                                 
    SP3:                                      -                                 
    SP4:                                                                        


    ECgene alternative splicing isoforms for SERINC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SERINC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCTATT
    SERINC5 Expression
    About this image


    SERINC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Gonad
             Primordial Germ Cells Allantois
    SERINC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERINC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288232

    UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
    Tissue specificity: Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte
    and is expressed weakly in the heart, liver and fetal brain

        Custom PCR Arrays for SERINC5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC5
    QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
    QuantiFast Probe-based Assays in human, mouse, rat SERINC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SERINC5 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serinc51 , 5 serine incorporator 51, 5 82.54(n)1
    81.96(a)1
      13 (47.75 cM)5
    2184421  NM_172588.21  NP_766176.11 
     926111385 
    chicken
    (Gallus gallus)
    Aves SERINC51 serine incorporator 5 73.75(n)
    76.36(a)
      427175  XM_424762.4  XP_424762.2 
    lizard
    (Anolis carolinensis)
    Reptilia SERINC56
    serine incorporator 5
    76(a)
    1 ↔ 1
    2(12417675-12465890)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70972 Xenopus laevis transcribed sequence with weak similarity more 78.76(n)    BJ621925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74672 Danio rerio mRNA similar to developmentally regulated more 75.55(n)    BC044159.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TMS16
    TMS1
    33(a)
    1 → many
    3L(16405822-16408486)
    worm
    (Caenorhabditis elegans)
    Secernentea R11H6.26
    Y57E12AL.16
    Protein R11H6.2 (R11H6.2) mRNA, complete cds
    Protein Y57E12AL.1, isoform a (Y57E12AL.1) mRNA, c...
    37(a)
    34(a)
    many ↔ many
    many ↔ many
    V(14597939-14600091) WBGene00011250
    V(7060811-7062817) WBGene00021956
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMS16
    Vacuolar membrane protein of unknown function that...
    26(a)
    1 → many
    IV(665349-666770) YDR105C


    ENSEMBL Gene Tree for SERINC5 (if available)
    TreeFam Gene Tree for SERINC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SERINC5 gene
    SERINC42  SERINC12  SERINC32  SERINC22  
    6 SIMAP similar genes for SERINC5 using alignment to 2 protein entries:     SERC5_HUMAN (see all proteins):
    FLJ00047    SERINC4    SERINC1    SERINC2    SHANK2    SERINC3

    SERINC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SERINC5 (see all 3552)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119560641,2
    C,F,H--79406619(+) GCAGGG/ATCTCC 2 -- ds50016Minor allele frequency- A:0.09NS EA WA 538
    rs1460665801,2
    --79406685(+) CACTGA/GCTGCA 2 -- ds50010--------
    rs1842378101,2
    --79406736(+) CCTTAC/TCAAAA 2 -- ds50010--------
    rs1487247161,2
    --79406784(+) AAAATA/GTAAAG 2 -- ds50010--------
    rs1882937611,2
    --79406880(+) TGTGGA/TCTGTA 2 -- ds50010--------
    rs1931883491,2
    --79406935(+) AAAACC/TATTTA 2 -- ds50010--------
    rs745269071,2
    C,F--79406942(+) TTTATC/TCATGT 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1828290461,2
    --79406966(+) AAAGTA/TTGATG 2 -- ds50010--------
    rs108059311,2
    C,F,A,H--79407163(+) GGGGAG/TGGGGA 2 -- ut312Minor allele frequency- T:0.13NA EA 240
    rs1120635561,2
    C,F--79407169(+) GGGGAG/ACCTAG 2 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SERINC5 (79407050 - 79551898 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SERINC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678473CNV Deletion23128226
    esv2677189CNV Deletion23128226
    esv2730364CNV Deletion23290073
    nsv516093CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERINC5
    DNA2.0 Custom Variant and Variant Library Synthesis for SERINC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614551    OMIM disorders: --


    SERINC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERINC5
    Human Genome Epidemiology (HuGE) Navigator: SERINC5 (1 document)

    Export disorders for SERINC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SERINC5 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SERINC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family. (PubMed id 12688535)1, 2, 3 Xu J.... Mao Y. (Mol. Biol. Rep. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genome-wide analyses of borderline personality features. (PubMed id 23979607)1 Lubke G.H....Boomsma D.I. (Mol. Psychiatry 2013)
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    5. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (Genome Biol. 2007)
    6. Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. (PubMed id 15637075)1 Uemura T....Igarashi K. (J. Biol. Chem. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 256987 HGNC: 18825 AceView: C5orf12 Ensembl:ENSG00000164300 euGenes: HUgn256987
    ECgene: SERINC5 H-InvDB: SERINC5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SERINC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SERINC5 gene:
    Search GeneIP for patents involving SERINC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SERINC5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SERINC5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SERINC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SERINC5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SERINC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERINC5   OriGene Custom Protein Services for SERINC5  

     
     
     Block miRNA regulation of human, mouse, rat SERINC5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SERINC5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERINC5 Predesigned siRNA for gene silencing in human, mouse, rat SERINC5
     QuantiFast Probe-based Assays in human, mouse, rat SERINC5 QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
     Custom PCR Arrays for SERINC5 Search Chromatin IP Primers for SERINC5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC5  Search GeneGlobe Interaction Network for SERINC5
     Regulatory tfbs in SERINC5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SERINC5 GenScript cDNA clones with any tag delivered in your preferred vector for SERINC5
     GenScript Custom Assay Services for SERINC5 GenScript Custom overexpressing Cell Line Services for SERINC5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SERINC5 (SERC5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SERINC5 antibodies
     SERINC5 lysates
     Search for Antibodies for SERINC5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SERINC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SERINC5
     Antibodies for SERINC5
     ELISAs for SERINC5
     CLIAs for SERINC5



     Browse ESI BIO Cell Lines and PureStem Progenitors for SERINC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SERINC5
     SwitchGear Promoter luciferase reporter plasmids for SERINC5
     Search ThermoFisher Antibodies for SERINC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERINC5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERINC5
     Search LSBio for Antibodies for SERINC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SERINC5 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4