Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERINC5 Gene

protein-coding   GIFtS: 46
GCID: GC05M079407

serine incorporator 5

(Previous name: chromosome 5 open reading frame 12 )
(Previous symbol: C5orf12)
  Search for SERINC5
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SERINC5    

Aliases
for SERINC5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine Incorporator 51 2
C5orf121 2 3
TPO11 2
Chromosome 5 Open Reading Frame 121

External Ids:    HGNC: 188251   Entrez Gene: 2569872   Ensembl: ENSG000001643007   OMIM: 6145515   UniProtKB: Q86VE93   

Export aliases for SERINC5 gene to outside databases

Previous GC identifers: GC05M079479 GC05M074614


Summaries
for SERINC5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing
serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)




Genomic Views
for SERINC5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERINC5 gene promoter:
         STAT1   AML1a   MyoD   RelA   LUN-1   AREB6   Ik-2   NRF-2   STAT3   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERINC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERINC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

SERINC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M079407:  view genomic region     (about GC identifiers)

Start:
 79,407,050 bp from pter      End:
 79,551,898 bp from pter
Size:
 144,849 bases      Orientation:
 minus strand

Proteins
for SERINC5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9 (See protein sequence)
Recommended Name: Serine incorporator 5  
Size: 423 amino acids; 47009 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B4DMH7 Q495A4 Q495A6
Alternative splicing: 4 isoforms:  Q86VE9-1   Q86VE9-2   Q86VE9-3   Q86VE9-4   

Explore the universe of human proteins at neXtProt for SERINC5: NX_Q86VE9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VE9

    • SERINC5 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001167542.1  NP_001167543.1  NP_840060.1  

    ENSEMBL proteins: 
     ENSP00000426134   ENSP00000421665   ENSP00000420863   ENSP00000426237  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SERINC5
    OriGene Custom Protein Services for SERINC5 
    GenScript Custom Purified and Recombinant Proteins Services for SERINC5
    Novus Biologicals SERINC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SERINC5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0043209myelin sheath IEA--


    SERINC5 for ontologies           About GeneDecksing



    SERINC5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SERINC5 
    GenScript Custom Superior Antibodies Services for SERINC5
    Novus Biologicals SERINC5 Antibody
    Search for Antibodies for SERINC5 at Abcam  
    Uscn Antibodies for SERINC5
    Search ThermoFisher Antibodies for SERINC5

    Assay Products for SERINC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERINC5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SERINC5

    Protein Domains /
    Families
    for SERINC5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SERINC5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005016 TMS_TDE
     IPR015460 TPO1

    Graphical View of Domain Structure for InterPro Entry Q86VE9

    ProtoNet protein and cluster: Q86VE9

    UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
    Similarity: Belongs to the TDE1 family


    Function
    for SERINC5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
    Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing
    serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SERINC5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERINC5
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SERINC5 (see all 67):
    hsa-miR-548j hsa-miR-607 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-548a-5p hsa-miR-761 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERINC5 (see all 7)
    OriGene shRNA RFP: SERINC5
    OriGene siRNA: SERINC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SERINC5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SERINC5 (NM_001174071)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SERINC5
    Search LifeMap BioReagents cell lines for SERINC5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5


    Pathways & Interactions
    for SERINC5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERINC5

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006658phosphatidylserine metabolic process ISS--
    GO:0008654phospholipid biosynthetic process IEA--
    GO:0042552myelination IEA--
    GO:0051347positive regulation of transferase activity ISS--


    SERINC5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SERINC5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERINC5

    10/124 HMDB Compounds for SERINC5 (see all 124)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----
    PS(14:0/20:4(5Z,8Z,11Z,14Z))PS(34:4) (see all 13)----
    Search CenterWatch for drugs/clinical trials and news about SERINC5 / SERC5 

    Transcripts
    for SERINC5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SERINC5 gene (3 alternative transcripts): 
    NM_001174071.1  NM_001174072.1  NM_178276.5  

    Unigene Cluster for SERINC5:

    Serine incorporator 5
    Hs.288232  [show with all ESTs]
    Unigene Representative Sequence: NM_001174072
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509193 ENST00000512972 ENST00000512721(uc011ctj.2) ENST00000502747
    ENST00000513907 ENST00000507668(uc003kgj.3 uc003kgm.3 uc003kgk.3 uc003kgl.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SERINC5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERINC5
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SERINC5 (see all 67):
    hsa-miR-548j hsa-miR-607 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-508-5p hsa-miR-548a-5p hsa-miR-761 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERINC5 (see all 7)
    OriGene shRNA RFP: SERINC5
    OriGene siRNA: SERINC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SERINC5 (NM_001174071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERINC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERINC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC5

    Additional cDNA sequence: 

    AF147384.1 AF498273.1 AK026295.1 AK297467.1 BC101280.2 BC101282.3 BC101283.2 CR936687.1 

    15 DOTS entries:

    DT.454633  DT.40131336  DT.91744342  DT.95181134  DT.40235451  DT.306770  DT.306771  DT.40283117 
    DT.120826868  DT.120826889  DT.92030462  DT.104351  DT.120826816  DT.91828401  DT.91911938 

    24/47 AceView cDNA sequences (see all 47):

    BM055374 BM709599 BM126283 T96046 BM055143 BM055085 BX509349 T96036 
    BF062191 AI075265 BU733615 CK818873 AA651940 NM_178276 N22401 CB266037 
    BX957061 AF498273 AA306511 BM126010 BI493649 AW005635 AI356352 BF057229 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SERINC5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                 -                                 
    SP2:                    -                 -                                 
    SP3:                                      -                                 
    SP4:                                                                        


    ECgene alternative splicing isoforms for SERINC5

    Expression
    for SERINC5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERINC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTTCTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SERINC5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneAutopod Long BoneBone
    BoneZeugopod Growth PlateBone
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Floor PlateNeural Tube
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for SERINC5

    SOURCE GeneReport for Unigene cluster: Hs.288232

    UniProtKB/Swiss-Prot: SERC5_HUMAN, Q86VE9
    Tissue specificity: Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and
    is expressed weakly in the heart, liver and fetal brain

        SABiosciences Custom PCR Arrays for SERINC5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERINC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERINC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5

    Orthologs
    for SERINC5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERINC5 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Serinc51 , 5 serine incorporator 51, 5 82.54(n)1
    81.96(a)1    		   13 (47.75 cM)5
    2184421  NM_172588.21  NP_766176.11 
     926111385 
    chicken
    (Gallus gallus)    		 Aves SERINC51 serine incorporator 5 73.75(n)
    76.36(a)    		   427175  XM_424762.3  XP_424762.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SERINC56
    		 --
    		 75(a)
    		 1 ↔ 1
    		 2(12437096-12461392)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.70972 Xenopus laevis transcribed sequence with weak similarity more 78.76(n)    BJ621925.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.74672 Danio rerio mRNA similar to developmentally regulated more 75.55(n)    BC044159.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G061706
    AT1G161806
    (see all 5)    		 serinc-domain containing protein
    (see all 5)    		 24(a)
    23(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 3(1867415-1869948)
    1(5540427-5542902)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 TMS membrane protein/tumour differentially express...
    TMS membrane protein/tumour differentially express...
    (see all 4)    		 25(a)
    22(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 2(33684870-33688279)
    3(19517381-19524458)


    ENSEMBL Gene Tree for SERINC5 (if available)
    TreeFam Gene Tree for SERINC5 (if available) 

    Paralogs
    for SERINC5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERINC5 gene
    ENSG000002625602  SERINC42  SERINC32  SERINC12  SERINC22  
    6 SIMAP similar genes for SERINC5 using alignment to 2 protein entries:     SERC5_HUMAN (see all proteins):
    FLJ00047    SERINC4    SERINC1    SERINC2    SHANK2    SERINC3

    SERINC5 for paralogs           About GeneDecksing



    Genomic Variants
    for SERINC5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3089 NCBI SNPs in SERINC5 are shown (see all 3089)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119560641,2
    		C,F,H,--79406619(+) GCAGGG/ATCTCC 2 -- ds50016Minor allele frequency- A:0.09NS EA WA 538
    rs1460665801,2
    		--79406685(+) CACTGA/GCTGCA 2 -- ds50010--------
    rs1842378101,2
    		--79406736(+) CCTTAC/TCAAAA 2 -- ds50010--------
    rs1487247161,2
    		--79406784(+) AAAATA/GTAAAG 2 -- ds50010--------
    rs1882937611,2
    		--79406880(+) TGTGGA/TCTGTA 2 -- ds50010--------
    rs1931883491,2
    		--79406935(+) AAAACC/TATTTA 2 -- ds50010--------
    rs745269071,2
    		F,--79406942(+) TTTATC/TCATGT 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1828290461,2
    		--79406966(+) AAAGTA/TTGATG 2 -- ds50010--------
    rs108059311,2
    		C,F,A,H,--79407163(+) GGGGAG/TGGGGA 2 -- ut312Minor allele frequency- T:0.13NA EA 240
    rs1120635561,2
    		C,--79407169(+) GGGGAG/ACCTAG 2 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SERINC5 (79407050 - 79551898 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SERINC5
         1 CNV: 51743

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERINC5
    DNA2.0 Custom Variant and Variant Library Synthesis for SERINC5

    Disorders / Diseases
    for SERINC5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SERINC5 for disorders           About MalaCards

    SERINC5 for disorders           About GeneDecksing

    OMIM gene information: 614551    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: SERINC5 (1 document)

    Export disorders for SERINC5 gene to outside databases

    Publications
    for SERINC5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERINC5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SERINC5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family. (PubMed id 12688535)1, 2, 3 Xu J.... Mao Y. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)
    4. Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. (PubMed id 15637075)1 Uemura T....Igarashi K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. TPO1, a member of a novel protein family, is developmentally regulated in cultured oligodendrocytes. (PubMed id 9326262)9 Krueger W.H....Pfeiffer S.E. (1997)
    10. Alternatively spliced form of human thyroperoxidase, TPOzanelli: activity, intracellular trafficking, and role in hormonogenesis. (PubMed id 11327880)9 Niccoli-Sire P....Franc J.L. (2001)

    External Searches for SERINC5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SERINC5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256987 HGNC: 18825 AceView: C5orf12 Ensembl:ENSG00000164300 euGenes: HUgn256987
    ECgene: SERINC5 H-InvDB: SERINC5

    Other Databases showing SERINC5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SERINC5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERINC5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SERINC5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SERINC5 gene:
    Search GeneIP for patents involving SERINC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SERINC5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SERINC5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERINC5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERINC5  
     OriGene Protein Over-expression Lysate for SERINC5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SERINC5   OriGene 3'-UTR Clone for SERINC5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERINC5   OriGene Custom Protein Services for SERINC5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERINC5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERINC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC5
     GenScript Custom Purified and Recombinant Proteins Services for SERINC5 GenScript cDNA clones with any tag delivered in your preferred vector for SERINC5
     GenScript Custom Assay Services for SERINC5 GenScript Custom Superior Antibodies Services for SERINC5
     GenScript Custom overexpressing Cell Line Services for SERINC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERINC5 promoter
     Search Chromatin IP Primers for SERINC5
     RT2 qPCR Primer Assay in human, mouse, rat SERINC5
     Search GNC Networks for SERINC5
     SABiosciences Custom PCR Arrays for SERINC5
     Search Tocris compounds for SERINC5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERINC5 antibodies
     SERINC5 lysates
     Search for Antibodies for SERINC5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SERINC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SERINC5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SERINC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SERINC5
     SwitchGear Promoter luciferase reporter plasmids for SERINC5
     Search ThermoFisher Antibodies for SERINC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SERINC5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4