Aliases for SERINC5 Gene
External Ids for SERINC5 Gene
Previous HGNC Symbols for SERINC5 Gene
Previous GeneCards Identifiers for SERINC5 Gene
GeneCards Summary for SERINC5 Gene
SERINC5 (Serine Incorporator 5) is a Protein Coding gene. Diseases associated with SERINC5 include Hiv-1. Among its related pathways are Amino acid synthesis and interconversion (transamination) and Viral mRNA Translation. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC4.
UniProtKB/Swiss-Prot for SERINC5 Gene
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).