SERINC4 Gene
protein-coding GIFtS: 35
GCID: GC15M044086
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serine incorporator 4
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Aliases
for SERINC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Incorporator 41 2 | | FLJ403631 |
Export aliases for SERINC4 gene to outside databasesPrevious GC identifers: GC15U900532 GC15M041874 GC15M044065 GC15M020910 |
Summaries
for SERINC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SERC4_HUMAN, A6NH21Function: Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derivedlipids, phosphatidylserine and sphingolipids
|
Genomic Views
for SERINC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERINC4 gene promoter:
NF-1 Tal-1beta E47 GATA-1 PPAR-alpha AREB6 Msx-1 Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERINC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.3SERINC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M044086: view genomic region
(about GC identifiers)
Start:
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44,086,360 bp from pter |
End:
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44,092,419 bp from pter |
Size:
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6,060 bases |
Orientation:
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minus strand |
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Proteins
for SERINC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SERC4_HUMAN, A6NH21 (See
protein sequence)Recommended Name: Serine incorporator 4 Size: 518 amino acids; 56870 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RN41 Q3YL75Alternative splicing: 2 isoforms: A6NH21-1 A6NH21-2 Explore the universe of human proteins at neXtProt for SERINC4: NX_A6NH21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NH21
SERINC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001244960.1 NP_001244961.1
ENSEMBL proteins: ENSP00000399074 ENSP00000402868 ENSP00000299969 ENSP00000319796 ENSP00000408781 ENSP00000249714
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SERINC4 for ontologies About GeneDecksing
SERINC4 Antibody Products:
Assay Products for SERINC4: |
Protein
Domains /
Families
for SERINC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERINC4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NH21ProtoNet protein and cluster: A6NH21 UniProtKB/Swiss-Prot: SERC4_HUMAN, A6NH21Similarity: Belongs to the TDE1 family |
Function
for SERINC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SERC4_HUMAN, A6NH21Function: Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derivedlipids, phosphatidylserine and sphingolipids
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SERINC4 (NM_001033517) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERINC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC4 |
|
Pathways & Interactions
for SERINC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERINC4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008654 | phospholipid biosynthetic process |
IEA | -- |
SERINC4 for ontologies About GeneDecksing
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Drugs & Compounds
for SERINC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERINC4
10/124 HMDB Compounds for SERINC4 (see all 124) About this table
Search CenterWatch for drugs/clinical trials and news about SERINC4 / SERC4
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Transcripts
for SERINC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERINC4 gene (2 alternative transcripts): NM_001258031.1 NM_001258032.1 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448553(uc001ztc.1) ENST00000457418 ENST00000299969 ENST00000319327
ENST00000412697 ENST00000476490 ENST00000249714(uc010bds.1 uc001zte.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SERINC4 (NM_001033517) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERINC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC4 |
GeneLoc Exon Structure
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Expression
for SERINC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERINC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SERINC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERINC4
SABiosciences Custom PCR Arrays for SERINC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERINC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SERINC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC4 |
Orthologs
for SERINC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SERINC4 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for SERINC4 (if available)
TreeFam Gene Tree for SERINC4 (if available) |
Paralogs
for SERINC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERINC4 gene
- ENSG000002625602 SERINC32 SERINC12 SERINC52 SERINC22
4 SIMAP similar genes for SERINC4 using alignment to 5 protein entries: SERC4_HUMAN (see all proteins):SERINC5 SERINC2 SERINC1 SERINC3
SERINC4 for paralogs About GeneDecksing
|
Genomic Variants
for SERINC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERINC4 (44086360 - 44092419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SERINC4
1 CNV: 3960 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERINC4 |
|
Disorders
/ Diseases
for SERINC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SERINC4 for disorders About MalaCards
SERINC4 for disorders About GeneDecksing
OMIM gene information: 614550
OMIM disorders: --
Export disorders for SERINC4 gene to outside databases
|
Publications
for SERINC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERINC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERINC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. (PubMed id 16120614)1, 2 Inuzuka M.... Ingi T. (2005)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SERINC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SERINC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERINC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERINC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERINC4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SERINC4 gene:
Search GeneIP for patents involving SERINC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERINC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERINC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERINC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERINC4 | | | OriGene Protein Over-expression Lysate for SERINC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERINC4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERINC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SERINC4 | | OriGene Custom Protein Services for SERINC4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERINC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERINC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC4 |
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| | | | Search Tocris compounds for SERINC4 |
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 | | | SERINC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for SERINC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC4 |
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