Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERINC4 Gene

Aliases for SERINC4 Gene

  • Serine Incorporator 4 2 3 5

External Ids for SERINC4 Gene

Previous GeneCards Identifiers for SERINC4 Gene

  • GC15U900532
  • GC15M041874
  • GC15M044065
  • GC15M020910
  • GC15M044086

Summaries for SERINC4 Gene

GeneCards Summary for SERINC4 Gene

SERINC4 (Serine Incorporator 4) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC5.

UniProtKB/Swiss-Prot for SERINC4 Gene

  • Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Additional gene information for SERINC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC4 Gene

Genomics for SERINC4 Gene

GeneHancer (GH) Regulatory Elements for SERINC4 Gene

Promoters and enhancers for SERINC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +3.7 3726 10.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D GC15M043788 GC15P043795 HYPK PIR54305 SERINC4 SERF2 SPG11 CTDSPL2 ENSG00000259563 RPS3AP47
GH15I043762 Enhancer 0.4 ENCODE 11.1 +37.2 37184 1.7 PAF1 ZNF316 MAFK ADAL HYPK MIR1282 SERINC4 TUBGCP4 ZSCAN29 SERF2 PDIA3 CATSPER2P1
GH15I043821 Enhancer 0.3 ENCODE 0.3 -21.5 -21537 0.2 FOS MFAP1 SERINC4
GH15I043822 Enhancer 0.3 Ensembl 0.3 -22.2 -22180 0.8 ZNF121 STRCP1 MFAP1 SERINC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SERINC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERINC4 gene promoter:

Genomic Locations for SERINC4 Gene

Genomic Locations for SERINC4 Gene
6,060 bases
Minus strand

Genomic View for SERINC4 Gene

Genes around SERINC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC4 Gene

Proteins for SERINC4 Gene

  • Protein details for SERINC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine incorporator 4
    Protein Accession:
    Secondary Accessions:
    • B2RN41
    • Q3YL75

    Protein attributes for SERINC4 Gene

    518 amino acids
    Molecular mass:
    56870 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC4 Gene


neXtProt entry for SERINC4 Gene

Post-translational modifications for SERINC4 Gene

No Post-translational modifications

Other Protein References for SERINC4 Gene

No data available for DME Specific Peptides for SERINC4 Gene

Domains & Families for SERINC4 Gene

Gene Families for SERINC4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SERINC4 Gene


Suggested Antigen Peptide Sequences for SERINC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TDE1 family.
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC4: view

Function for SERINC4 Gene

Molecular function for SERINC4 Gene

UniProtKB/Swiss-Prot Function:
Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Gene Ontology (GO) - Molecular Function for SERINC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC4: view

Phenotypes for SERINC4 Gene

genes like me logo Genes that share phenotypes with SERINC4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERINC4 Gene

Localization for SERINC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SERINC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERINC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERINC4 Gene

Pathways & Interactions for SERINC4 Gene

genes like me logo Genes that share pathways with SERINC4: view

Interacting Proteins for SERINC4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000319796 for SERINC4 Gene via STRING

Gene Ontology (GO) - Biological Process for SERINC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process IEA --
GO:0015825 L-serine transport IEA --
genes like me logo Genes that share ontologies with SERINC4: view

No data available for SIGNOR curated interactions for SERINC4 Gene

Drugs & Compounds for SERINC4 Gene

(124) Additional Compounds for SERINC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC4: view

Transcripts for SERINC4 Gene

mRNA/cDNA for SERINC4 Gene

(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC4 Gene

No ASD Table

Relevant External Links for SERINC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERINC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC4 Gene

mRNA expression in normal human tissues for SERINC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC4 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERINC4 Gene

Protein tissue co-expression partners for SERINC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERINC4 Gene:


Evidence on tissue expression from TISSUES for SERINC4 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with SERINC4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC4 Gene

Orthologs for SERINC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERINC4 33 34
  • 99.55 (n)
(Canis familiaris)
Mammalia SERINC4 33 34
  • 88.51 (n)
(Bos Taurus)
Mammalia SERINC4 33 34
  • 87.41 (n)
(Mus musculus)
Mammalia Serinc4 33 16 34
  • 85.16 (n)
(Monodelphis domestica)
Mammalia SERINC4 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SERINC4 34
  • 68 (a)
(Gallus gallus)
Aves SERINC4 33 34
  • 69.58 (n)
(Anolis carolinensis)
Reptilia SERINC4 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc4 33
  • 59.61 (n)
(Danio rerio)
Actinopterygii LOC570112 33
  • 60.04 (n)
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea R11H6.2 34
  • 32 (a)
Y57E12AL.1 34
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for SERINC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC4 Gene

Gene Tree for SERINC4 (if available)
Gene Tree for SERINC4 (if available)

Paralogs for SERINC4 Gene

Paralogs for SERINC4 Gene

(4) SIMAP similar genes for SERINC4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SERINC4: view

Variants for SERINC4 Gene

Sequence variations from dbSNP and Humsavar for SERINC4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000304083 -- 43,796,488(-) T/G intron_variant
rs1001772451 -- 43,798,138(-) C/G/T intron_variant
rs1002247456 -- 43,798,011(-) A/G coding_sequence_variant, missense_variant, synonymous_variant
rs1002691442 -- 43,794,588(-) G/A 3_prime_UTR_variant
rs1002792741 -- 43,795,252(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC4 Gene

Variant ID Type Subtype PubMed ID
esv2760028 CNV gain+loss 17122850
nsv1036318 CNV gain 25217958

Variation tolerance for SERINC4 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERINC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC4 Gene

Disorders for SERINC4 Gene

Additional Disease Information for SERINC4

No disorders were found for SERINC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC4 Gene

Publications for SERINC4 Gene

  1. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. (PMID: 16120614) Inuzuka M … Ingi T (The Journal of biological chemistry 2005) 3 4 58
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SERINC4 Gene

Sources for SERINC4 Gene

Loading form....