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Aliases for SERINC4 Gene

Aliases for SERINC4 Gene

  • Serine Incorporator 4 2 3 5

External Ids for SERINC4 Gene

Previous GeneCards Identifiers for SERINC4 Gene

  • GC15U900532
  • GC15M041874
  • GC15M044065
  • GC15M020910
  • GC15M044086

Summaries for SERINC4 Gene

GeneCards Summary for SERINC4 Gene

SERINC4 (Serine Incorporator 4) is a Protein Coding gene. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC2.

UniProtKB/Swiss-Prot for SERINC4 Gene

  • Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC4 Gene

Genomics for SERINC4 Gene

Regulatory Elements for SERINC4 Gene

Promoters for SERINC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERINC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERINC4 Gene

Chromosome:
15
Start:
43,794,162 bp from pter
End:
43,800,221 bp from pter
Size:
6,060 bases
Orientation:
Minus strand

Genomic View for SERINC4 Gene

Genes around SERINC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC4 Gene

Proteins for SERINC4 Gene

  • Protein details for SERINC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NH21-SERC4_HUMAN
    Recommended name:
    Serine incorporator 4
    Protein Accession:
    A6NH21
    Secondary Accessions:
    • B2RN41
    • Q3YL75

    Protein attributes for SERINC4 Gene

    Size:
    518 amino acids
    Molecular mass:
    56870 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC4 Gene

Proteomics data for SERINC4 Gene at MOPED

Post-translational modifications for SERINC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC4 Gene

Antibody Products

No data available for DME Specific Peptides for SERINC4 Gene

Domains & Families for SERINC4 Gene

Protein Domains for SERINC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SERINC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NH21

UniProtKB/Swiss-Prot:

SERC4_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC4: view

No data available for Gene Families for SERINC4 Gene

Function for SERINC4 Gene

Molecular function for SERINC4 Gene

UniProtKB/Swiss-Prot Function:
Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.

Phenotypes for SERINC4 Gene

GenomeRNAi human phenotypes for SERINC4:
genes like me logo Genes that share phenotypes with SERINC4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SERINC4 Gene

Localization for SERINC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERINC4 Gene COMPARTMENTS Subcellular localization image for SERINC4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SERINC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SERINC4: view

Pathways & Interactions for SERINC4 Gene

SuperPathways for SERINC4 Gene

No Data Available

Interacting Proteins for SERINC4 Gene

Gene Ontology (GO) - Biological Process for SERINC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with SERINC4: view

No data available for Pathways by source and SIGNOR curated interactions for SERINC4 Gene

Drugs & Compounds for SERINC4 Gene

(124) Additional Compounds for SERINC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC4: view

Transcripts for SERINC4 Gene

mRNA/cDNA for SERINC4 Gene

(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC4 Gene

No ASD Table

Relevant External Links for SERINC4 Gene

GeneLoc Exon Structure for
SERINC4
ECgene alternative splicing isoforms for
SERINC4

Expression for SERINC4 Gene

mRNA expression in normal human tissues for SERINC4 Gene

mRNA expression in normal human tissues for SERINC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC4 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERINC4 Gene



genes like me logo Genes that share expression patterns with SERINC4: view

Protein tissue co-expression partners for SERINC4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERINC4 Gene

Orthologs for SERINC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERINC4 35
  • 87.41 (n)
  • 85.06 (a)
SERINC4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERINC4 35
  • 88.51 (n)
  • 85.78 (a)
SERINC4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serinc4 35
  • 85.16 (n)
  • 82.52 (a)
Serinc4 16
Serinc4 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERINC4 35
  • 99.55 (n)
  • 99.81 (a)
SERINC4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERINC4 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC4 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC4 35
  • 69.58 (n)
  • 67.46 (a)
SERINC4 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC4 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc4 35
  • 59.61 (n)
  • 54.34 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570112 35
  • 60.04 (n)
  • 54.75 (a)
SERINC4 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TMS1 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 36
  • 32 (a)
ManyToMany
Y57E12AL.1 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for SERINC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC4 Gene

ENSEMBL:
Gene Tree for SERINC4 (if available)
TreeFam:
Gene Tree for SERINC4 (if available)

Paralogs for SERINC4 Gene

Paralogs for SERINC4 Gene

(4) SIMAP similar genes for SERINC4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SERINC4: view

Variants for SERINC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SERINC4 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850

Variation tolerance for SERINC4 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC4 Gene

HapMap Linkage Disequilibrium report
SERINC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SERINC4 Gene

Disorders for SERINC4 Gene

Relevant External Links for SERINC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC4

No disorders were found for SERINC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC4 Gene

Publications for SERINC4 Gene

  1. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. (PMID: 16120614) Inuzuka M. … Ingi T. (J. Biol. Chem. 2005) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SERINC4 Gene

Sources for SERINC4 Gene

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