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SERINC3 Gene

protein-coding   GIFtS: 55
GCID: GC20M043124

Serine Incorporator 3

(Previous name: tumor differentially expressed 1)
(Previous symbol: TDE1)
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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Incorporator 31 2     SBBI992
TDE11 2 3 5     TDE2
Tumor Differentially Expressed 11 2     TMS-12
Tumor Differentially Expressed Protein 12 3     Placental Transmembrane Protein (Mouse Testicular Tumor Differentially
Expressed)2
DIFF332 3     Transmembrane Protein SBBI992
AIGP12     Tumour Differentially Expressed 12

External Ids:    HGNC: 116991   Entrez Gene: 109552   Ensembl: ENSG000001328247   OMIM: 6071655   UniProtKB: Q135303   

Export aliases for SERINC3 gene to outside databases

Previous GC identifers: GC20M042559 GC20M039866


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERINC3 Gene:
SERINC3 (serine incorporator 3) is a protein-coding gene. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
Function: May be involved in cellular transformation

Gene Wiki entry for SERINC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERINC3 gene promoter:
         Elk-1   LUN-1   LCR-F1   AREB6   MZF-1   E2F   E2F-1   Pax-4a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SERINC3 promoter sequence
   Search Chromatin IP Primers for SERINC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERINC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

SERINC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043124:  view genomic region     (about GC identifiers)

Start:
43,124,862 bp from pter      End:
43,150,750 bp from pter
Size:
25,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530 (See protein sequence)
Recommended Name: Serine incorporator 3  
Size: 473 amino acids; 52580 Da
Sequence caution: Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Sequence=AAD34641.1;
Type=Frameshift; Positions=321, 393, 407, 459;
Secondary accessions: O43717 Q9BR33

Explore the universe of human proteins at neXtProt for SERINC3: NX_Q13530

Explore proteomics data for SERINC3 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn34
  • Modification sites at PhosphoSitePlus

  • See SERINC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006802.1  NP_945179.1  

    ENSEMBL proteins: 
     ENSP00000414197   ENSP00000340243   ENSP00000255175   ENSP00000440966  

    SERINC3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERINC3
    OriGene Protein Over-expression Lysate for SERINC3
    OriGene MassSpec for SERINC3
    OriGene Custom Protein Services for SERINC3
    GenScript Custom Purified and Recombinant Proteins Services for SERINC3
    Novus Biologicals SERINC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERINC3

     
    Search eBioscience for Proteins for SERINC3 

     
    Search antibodies-online for proteins for SERINC3 

     
    antibodies-online peptides for SERINC3

    SERINC3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SERINC3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SERINC3
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    Novus Biologicals SERINC3 Antibodies
    Abcam antibodies for SERINC3
    Cloud-Clone Corp. Antibodies for SERINC3
    ThermoFisher Antibodies for SERINC3
    LSBio Antibodies in human, mouse, rat for SERINC3
    antibodies-online antibodies for SERINC3 (32 products) 

    SERINC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERINC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERINC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SERINC3
    Cloud-Clone Corp. CLIAs for SERINC3
    Search eBioscience for ELISAs for SERINC3 
    antibodies-online kits for SERINC3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005016 TMS_TDE

    Graphical View of Domain Structure for InterPro Entry Q13530

    ProtoNet protein and cluster: Q13530

    1 Blocks protein domain: IPB005016 TMS membrane protein/tumour differentially expressed protein

    UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
    Similarity: Belongs to the TDE1 family


    Find genes that share domains with SERINC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERC3_HUMAN, Q13530
    Function: May be involved in cellular transformation

    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Serinc3):

     skeleton 

    Find genes that share phenotypes with SERINC3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERINC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERINC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERINC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERINC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERINC3:
    hsa-mir-130b-3p (MIRT020296), hsa-mir-615-3p (MIRT039739), hsa-mir-19b-3p (MIRT031259), hsa-mir-218-5p (MIRT024221), hsa-mir-204-5p (MIRT005842)

    Block miRNA regulation of human, mouse, rat SERINC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERINC3 (see all 20):
    hsa-miR-513a-5p hsa-miR-301a hsa-miR-340 hsa-miR-3133 hsa-miR-20b* hsa-miR-130b hsa-miR-412 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSERINC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SERINC3
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERINC3

    Clone
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    OriGene clones in human, mouse for SERINC3 (see all 11)
    OriGene ORF clones in mouse, rat for SERINC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERINC3 (NM_006811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERINC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SERINC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SERC3_HUMAN, Q13530: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus2
    endoplasmic reticulum1
    extracellular1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SERINC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SERINC3: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SERINC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SERINC3 (Q135303 ENSP000002551754) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDELR2P339473, ENSP000002587394I2D: score=2 STRING: ENSP00000258739
    SURF4O152603, ENSP000003610574I2D: score=2 STRING: ENSP00000361057
    VDAC2P458803, ENSP000003616864I2D: score=2 STRING: ENSP00000361686
    PTPLAD1Q9P0353, ENSP000002618754I2D: score=2 STRING: ENSP00000261875
    XPO5Q9HAV43, ENSP000002653514I2D: score=2 STRING: ENSP00000265351
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:1902237positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA--

    Find genes that share ontologies with SERINC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERINC3 (SERC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERINC3 gene (2 alternative transcripts): 
    NM_006811.2  NM_198941.1  

    Unigene Cluster for SERINC3:

    Serine incorporator 3
    Hs.272168  [show with all ESTs]
    Unigene Representative Sequence: NM_006811
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411544 ENST00000342374(uc002xmf.1 uc010ggs.1 uc010zwp.1)
    ENST00000468234 ENST00000255175(uc002xme.3) ENST00000541235
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERINC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERINC3 (see all 20):
    hsa-miR-513a-5p hsa-miR-301a hsa-miR-340 hsa-miR-3133 hsa-miR-20b* hsa-miR-130b hsa-miR-412 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSERINC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERINC3
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC3
    Clone
    Products:
         
    OriGene clones in human, mouse for SERINC3 (see all 11)
    OriGene ORF clones in mouse, rat for SERINC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERINC3 (NM_006811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERINC3
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC3
      QuantiTect SYBR Green Assays in human, mouse, rat SERINC3
      QuantiFast Probe-based Assays in human, mouse, rat SERINC3

    Additional mRNA sequence: 

    AF112227.1 AF153979.1 AK222923.1 AK295120.1 AK300618.1 AK309993.1 BC006088.1 U49188.1 

    Selected DOTS entries (see all 25):

    DT.454945  DT.95270601  DT.100702738  DT.100852073  DT.92325328  DT.100852076  DT.95270593  DT.100829318 
    DT.95270578  DT.100852071  DT.95270596  DT.100852078  DT.100852081  DT.120837493  DT.92448907  DT.100044820 
    DT.40116277  DT.120837413  DT.120837419  DT.120837505  DT.92058288  DT.92448911  DT.92428113  DT.95270572 

    Selected AceView cDNA sequences (see all 706):

    BM717317 BU690062 BX363710 BQ001450 AW024289 AI658699 CB162425 AA294859 
    AI697551 BE384697 BI825213 AW269395 NM_006811 BP365865 BP360377 AI680627 
    AA974333 CB134044 AA975924 AA382817 BF476018 BQ128333 BI823429 CA417298 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                    -     -     -           -                                                                           
    SP2:                    -     -     -           -                       -                                                   
    SP3:                    -                       -                                                                           
    SP4:                                                                                                              -         
    SP5:                    -     -     -                                                                                       


    ECgene alternative splicing isoforms for SERINC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERINC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAATATAT
    SERINC3 Expression
    About this image


    SERINC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    SERINC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERINC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272168

    UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
    Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues
    compared with normal pulmonary tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including SERINC3: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SERINC3
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC3
    QuantiTect SYBR Green Assays in human, mouse, rat SERINC3
    QuantiFast Probe-based Assays in human, mouse, rat SERINC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERINC3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serinc31 , 5 serine incorporator 31, 5 82.34(n)1
    78.18(a)1
      2 (84.38 cM)5
    269431  NM_012032.41  NP_036162.31 
     1636232725 
    chicken
    (Gallus gallus)
    Aves SERINC31 serine incorporator 3 70.62(n)
    69.28(a)
      419196  NM_001006291.1  NP_001006291.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERINC36
    serine incorporator 3
    72(a)
    1 ↔ 1
    4(144061184-144076294)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.12262 Transcribed sequence with weak similarity to protein more 73.64(n)    141991957 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005356831 serine incorporator 3-like 61.92(n)
    57.75(a)
      100535683  XM_003199409.2  XP_003199457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TMS16
    TMS1
    40(a)
    1 → many
    3L(16405822-16408486)
    worm
    (Caenorhabditis elegans)
    Secernentea R11H6.26
    Y57E12AL.16
    Protein R11H6.2 (R11H6.2) mRNA, complete cds
    Protein Y57E12AL.1, isoform a (Y57E12AL.1) mRNA, c...
    43(a)
    43(a)
    many ↔ many
    many ↔ many
    V(14597939-14600091) WBGene00011250
    V(7060811-7062817) WBGene00021956
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMS1(YDR105C)4 Vacuolar membrane protein of unknown function that more   --   4(666770-665349) 851682  NP_010390.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G161801 AT1G16180 48.05(n)
    34.91(a)
      838187  NM_001198079.1  NP_001185008.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07929001 Os02g0792900 48.05(n)
    37.56(a)
      4330983  NM_001054899.1  NP_001048364.1 


    ENSEMBL Gene Tree for SERINC3 (if available)
    TreeFam Gene Tree for SERINC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERINC3 gene
    SERINC42  SERINC12  SERINC52  SERINC22  
    4 SIMAP similar genes for SERINC3 using alignment to 5 protein entries:     SERC3_HUMAN (see all proteins):
    SERINC1    SERINC2    SERINC5    SERINC4

    Find genes that share paralogs with SERINC3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SERINC3
    PGOHUM00000249396


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERINC3 (see all 597)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61306261,2
    C,H--43124478(+) CACTAG/TGGATA 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs1446499351,2
    C--43124558(+) TAGAGA/GAGCAA 1 -- ds50010--------
    rs1487106831,2
    --43124594(+) AAACTA/TGGTTC 1 -- ds50010--------
    rs1902812441,2
    --43124597(+) CTAGGC/TTCCCA 1 -- ds50010--------
    rs1828471191,2
    --43124730(+) AGAACC/TCTTAA 1 -- ds50010--------
    rs413087011,2
    C--43124780(+) AACCAC/TAGGCA 1 -- ds50010--------
    rs1882063111,2
    --43124856(+) CCTTAC/GAGGCA 1 -- ds50010--------
    rs130438331,2
    C,H--43124910(+) TGTGGT/GTTCTA 1 -- ut314Minor allele frequency- G:0.00NS EA 416
    rs61037531,2
    H--43124941(+) ACATAG/AGCATG 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1422900041,2
    --43125070(+) CATAAA/GCCTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SERINC3 (43124862 - 43150750 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SERINC3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERINC3
    DNA2.0 Custom Variant and Variant Library Synthesis for SERINC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607165    OMIM disorders: --


    Find genes that share disorders with SERINC3           About GenesLikeMe


    Export disorders for SERINC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERINC3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SERINC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PubMed id 10559794)1, 2, 3 Bossolasco M.... Mes-Masson A.-M. (Mol. Carcinog. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. (PubMed id 22925353)1 Lee H.J....Kelsoe J.R. (J Affect Disord 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    9. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. (PubMed id 16547497)1 Bossolasco M....Mes-Masson A.M. (Oncogene 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10955 HGNC: 11699 AceView: TDE1 Ensembl:ENSG00000132824 euGenes: HUgn10955
    ECgene: SERINC3 H-InvDB: SERINC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERINC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERINC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERINC3 gene:
    Search GeneIP for patents involving SERINC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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