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Aliases for SERINC3 Gene

Aliases for SERINC3 Gene

  • Serine Incorporator 3 2 3 5
  • Tumor Differentially Expressed Protein 1 3 4
  • DIFF33 3 4
  • TDE1 3 4
  • Tumor Differentially Expressed 1 2
  • SBBI99 3
  • TMS-1 3
  • AIGP1 3
  • TDE 3

External Ids for SERINC3 Gene

Previous HGNC Symbols for SERINC3 Gene

  • TDE1

Previous GeneCards Identifiers for SERINC3 Gene

  • GC20M042559
  • GC20M043124
  • GC20M039866

Summaries for SERINC3 Gene

GeneCards Summary for SERINC3 Gene

SERINC3 (Serine Incorporator 3) is a Protein Coding gene. Diseases associated with SERINC3 include Carbuncle and Hiv-1. Among its related pathways are Amino acid synthesis and interconversion (transamination) and Viral mRNA Translation. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

UniProtKB/Swiss-Prot for SERINC3 Gene

  • Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Gene Wiki entry for SERINC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC3 Gene

Genomics for SERINC3 Gene

Regulatory Elements for SERINC3 Gene

Enhancers for SERINC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G044690 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -171.9 -171934 6.4 FOXA2 MLX ARID4B SIN3A SLC30A9 FOS DEK SP5 ZHX2 MXD4 LINC01260 WISP2 KCNK15 KCNK15-AS1 ADA SERINC3 PKIG PIGT PABPC1L ENSG00000283440
GH20G044594 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -72.7 -72724 1.3 TAL1 UBTF EBF1 ZNF644 RELA FOSL1 TCF12 ELK1 EED FOS PKIG SERINC3 ADA LINC01430 LINC01620 TTPAL PIR61280
GH20G044493 1.4 FANTOM5 ENCODE dbSUPER 13.2 +26.2 26154 4.8 PKNOX1 JUN CEBPG EBF1 FOSL1 ZNF664 POLR2A EED SCRT2 FOSL2 PKIG TTPAL SERINC3 RPL37AP1 LINC01620 LINC01430 OSER1 ADA STK4 GC20P044495
GH20G044540 1.3 Ensembl ENCODE dbSUPER 12.4 -20.5 -20548 4.5 ARNT TAL1 JUN TCF12 ZFHX2 EGR1 NCOR1 FOS MAFK EGR2 SERINC3 PKIG PIR61280
GH20G044683 1.4 Ensembl ENCODE dbSUPER 10.5 -162.6 -162603 2.5 SIN3A ZNF48 YY1 SLC30A9 ELK1 ZNF143 DEK MIER2 REST PPARG LINC01260 ADA KCNK15 WISP2 KCNK15-AS1 SERINC3 PKIG OSER1-AS1 ENSG00000283440
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERINC3 on UCSC Golden Path with GeneCards custom track

Promoters for SERINC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137533 309 1201 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SERINC3 Gene

Chromosome:
20
Start:
44,496,221 bp from pter
End:
44,522,109 bp from pter
Size:
25,889 bases
Orientation:
Minus strand

Genomic View for SERINC3 Gene

Genes around SERINC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC3 Gene

Proteins for SERINC3 Gene

  • Protein details for SERINC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13530-SERC3_HUMAN
    Recommended name:
    Serine incorporator 3
    Protein Accession:
    Q13530
    Secondary Accessions:
    • B4DUE9
    • O43717
    • Q9BR33

    Protein attributes for SERINC3 Gene

    Size:
    473 amino acids
    Molecular mass:
    52580 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305}; Sequence=AAD34641.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305};

    Alternative splice isoforms for SERINC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC3 Gene

Post-translational modifications for SERINC3 Gene

Other Protein References for SERINC3 Gene

No data available for DME Specific Peptides for SERINC3 Gene

Domains & Families for SERINC3 Gene

Protein Domains for SERINC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13530

UniProtKB/Swiss-Prot:

SERC3_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC3: view

No data available for Gene Families for SERINC3 Gene

Function for SERINC3 Gene

Molecular function for SERINC3 Gene

UniProtKB/Swiss-Prot Function:
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Gene Ontology (GO) - Molecular Function for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
GO:1905361 L-serine transporter activity TAS --
genes like me logo Genes that share ontologies with SERINC3: view

Phenotypes for SERINC3 Gene

genes like me logo Genes that share phenotypes with SERINC3: view

Animal Models for SERINC3 Gene

MGI Knock Outs for SERINC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERINC3 Gene

Localization for SERINC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC3 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Cytoplasm, perinuclear region. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305 PubMed:26416734}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
extracellular 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERINC3: view

Pathways & Interactions for SERINC3 Gene

genes like me logo Genes that share pathways with SERINC3: view

Gene Ontology (GO) - Biological Process for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006564 L-serine biosynthetic process TAS --
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0009597 detection of virus IDA 26416733
genes like me logo Genes that share ontologies with SERINC3: view

No data available for SIGNOR curated interactions for SERINC3 Gene

Drugs & Compounds for SERINC3 Gene

No Compound Related Data Available

Transcripts for SERINC3 Gene

Unigene Clusters for SERINC3 Gene

Serine incorporator 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for SERINC3 Gene

GeneLoc Exon Structure for
SERINC3
ECgene alternative splicing isoforms for
SERINC3

Expression for SERINC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC3 Gene

This gene is overexpressed in Placenta (20.7), Testis (14.7), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERINC3 Gene



Protein tissue co-expression partners for SERINC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERINC3 Gene:

SERINC3

SOURCE GeneReport for Unigene cluster for SERINC3 Gene:

Hs.272168

mRNA Expression by UniProt/SwissProt for SERINC3 Gene:

Q13530-SERC3_HUMAN
Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Evidence on tissue expression from TISSUES for SERINC3 Gene

  • Nervous system(4.9)
  • Pancreas(4.3)
  • Lung(3.6)
  • Liver(3.5)
  • Heart(3.1)
  • Kidney(2.7)
  • Muscle(2.6)
  • Blood(2.3)
  • Skin(2.3)
  • Intestine(2.1)
  • Stomach(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SERINC3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC3 Gene

Orthologs for SERINC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC3 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SERINC3 34 35
  • 87.03 (n)
cow
(Bos Taurus)
Mammalia SERINC3 34 35
  • 84.32 (n)
mouse
(Mus musculus)
Mammalia Serinc3 34 16 35
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Serinc3 34
  • 80.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SERINC3 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC3 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC3 34 35
  • 70.62 (n)
lizard
(Anolis carolinensis)
Reptilia SERINC3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc3 34
  • 66.81 (n)
Str.1226 34
zebrafish
(Danio rerio)
Actinopterygii LOC100535683 34
  • 61.92 (n)
SERINC3 35
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TMS1 35
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 35
  • 43 (a)
ManyToMany
Y57E12AL.1 35
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 35 37
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16180 34
  • 48.05 (n)
rice
(Oryza sativa)
Liliopsida Os02g0792900 34
  • 48.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
Species where no ortholog for SERINC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC3 Gene

ENSEMBL:
Gene Tree for SERINC3 (if available)
TreeFam:
Gene Tree for SERINC3 (if available)

Paralogs for SERINC3 Gene

Paralogs for SERINC3 Gene

(4) SIMAP similar genes for SERINC3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SERINC3 Gene

genes like me logo Genes that share paralogs with SERINC3: view

Variants for SERINC3 Gene

Sequence variations from dbSNP and Humsavar for SERINC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000174768 -- 44,513,250(+) GGGGA(A/C)CGAGG intron-variant
rs1000245326 -- 44,523,000(+) CCTGT(A/G)GTGTG upstream-variant-2KB
rs1000255314 -- 44,508,252(+) GGCAA(A/G)GCAGG intron-variant
rs1000283629 -- 44,517,069(+) TGGTT(C/T)GCAGC intron-variant
rs1000289603 -- 44,504,530(+) CAGCT(C/T)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC3 Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958
nsv586065 CNV gain 21841781

Variation tolerance for SERINC3 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC3 Gene

Disorders for SERINC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SERINC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
carbuncle
  • carbuncle and furuncle of any part of face except eye
hiv-1
  • aids, slow progression to
alzheimer's disease 13
  • ad13
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERINC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC3
genes like me logo Genes that share disorders with SERINC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERINC3 Gene

Publications for SERINC3 Gene

  1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PMID: 10559794) Bossolasco M. … Mes-Masson A.-M. (Mol. Carcinog. 1999) 2 3 4 64
  2. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. (PMID: 26416733) Usami Y. … GAPttlinger H.G. (Nature 2015) 3 4 64
  3. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. (PMID: 26416734) Rosa A. … Pizzato M. (Nature 2015) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for SERINC3 Gene

Sources for SERINC3 Gene

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