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Aliases for SERINC3 Gene

Aliases for SERINC3 Gene

  • Serine Incorporator 3 2 3
  • TDE1 3 4 6
  • Tumor Differentially Expressed Protein 1 3 4
  • Tumor Differentially Expressed 1 2 3
  • DIFF33 3 4
  • Placental Transmembrane Protein (Mouse Testicular Tumor Differentially Expressed) 3
  • Tumour Differentially Expressed 1 3
  • Transmembrane Protein SBBI99 3
  • SBBI99 3
  • AIGP1 3
  • TMS-1 3
  • TDE 3

External Ids for SERINC3 Gene

Previous HGNC Symbols for SERINC3 Gene

  • TDE1

Previous GeneCards Identifiers for SERINC3 Gene

  • GC20M042559
  • GC20M043124
  • GC20M039866

Summaries for SERINC3 Gene

GeneCards Summary for SERINC3 Gene

SERINC3 (Serine Incorporator 3) is a Protein Coding gene. An important paralog of this gene is SERINC2.

UniProtKB/Swiss-Prot for SERINC3 Gene

  • May be involved in cellular transformation

Gene Wiki entry for SERINC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC3 Gene

Genomics for SERINC3 Gene

Regulatory Elements for SERINC3 Gene

Genomic Location for SERINC3 Gene

Start:
44,496,221 bp from pter
End:
44,522,109 bp from pter
Size:
25,889 bases
Orientation:
Minus strand

Genomic View for SERINC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERINC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC3 Gene

Proteins for SERINC3 Gene

  • Protein details for SERINC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13530-SERC3_HUMAN
    Recommended name:
    Serine incorporator 3
    Protein Accession:
    Q13530
    Secondary Accessions:
    • B4DUE9
    • O43717
    • Q9BR33

    Protein attributes for SERINC3 Gene

    Size:
    473 amino acids
    Molecular mass:
    52580 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305}; Sequence=AAD34641.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305};

    Alternative splice isoforms for SERINC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC3 Gene

Proteomics data for SERINC3 Gene at MOPED

Post-translational modifications for SERINC3 Gene

Other Protein References for SERINC3 Gene

No data available for DME Specific Peptides for SERINC3 Gene

Domains for SERINC3 Gene

Protein Domains for SERINC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13530

UniProtKB/Swiss-Prot:

SERC3_HUMAN :
  • Q13530
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC3: view

No data available for Gene Families for SERINC3 Gene

Function for SERINC3 Gene

Molecular function for SERINC3 Gene

UniProtKB/Swiss-Prot Function: May be involved in cellular transformation

Gene Ontology (GO) - Molecular Function for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC3: view

Phenotypes for SERINC3 Gene

MGI mutant phenotypes for SERINC3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SERINC3: view

miRNA for SERINC3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERINC3 Gene

Localization for SERINC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERINC3 Gene COMPARTMENTS Subcellular localization image for SERINC3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERINC3: view

Pathways for SERINC3 Gene

SuperPathways for SERINC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0015825 L-serine transport IBA --
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with SERINC3: view

No data available for Pathways by source for SERINC3 Gene

Transcripts for SERINC3 Gene

Unigene Clusters for SERINC3 Gene

Serine incorporator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for SERINC3 Gene

GeneLoc Exon Structure for
SERINC3
ECgene alternative splicing isoforms for
SERINC3

Expression for SERINC3 Gene

mRNA expression in normal human tissues for SERINC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERINC3 Gene

SOURCE GeneReport for Unigene cluster for SERINC3 Gene Hs.272168

mRNA Expression by UniProt/SwissProt for SERINC3 Gene

Q13530-SERC3_HUMAN
Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues
genes like me logo Genes that share expressions with SERINC3: view

No data available for mRNA differential expression in normal tissues for SERINC3 Gene

Orthologs for SERINC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC3 35
  • 99.44 (n)
  • 99.79 (a)
SERINC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERINC3 35
  • 84.32 (n)
  • 81.36 (a)
SERINC3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERINC3 35
  • 87.03 (n)
  • 85.41 (a)
SERINC3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serinc3 35
  • 82.34 (n)
  • 78.18 (a)
Serinc3 16
Serinc3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERINC3 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC3 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serinc3 35
  • 80.72 (n)
  • 77.75 (a)
chicken
(Gallus gallus)
Aves SERINC3 35
  • 70.62 (n)
  • 69.28 (a)
SERINC3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc3 35
  • 66.81 (n)
  • 67.02 (a)
Str.1226 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535683 35
  • 61.92 (n)
  • 57.75 (a)
SERINC3 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TMS1 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 36
  • 43 (a)
ManyToMany
Y57E12AL.1 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 36
  • 31 (a)
OneToMany
TMS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16180 35
  • 48.05 (n)
  • 34.91 (a)
rice
(Oryza sativa)
Liliopsida Os02g0792900 35
  • 48.05 (n)
  • 37.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for SERINC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC3 Gene

ENSEMBL:
Gene Tree for SERINC3 (if available)
TreeFam:
Gene Tree for SERINC3 (if available)

Paralogs for SERINC3 Gene

Paralogs for SERINC3 Gene

Selected SIMAP similar genes for SERINC3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SERINC3 Gene

genes like me logo Genes that share paralogs with SERINC3: view

Variants for SERINC3 Gene

Sequence variations from dbSNP and Humsavar for SERINC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6606 -- 44,499,362(+) CAGAC(C/T)GTAAT utr-variant-3-prime, intron-variant
rs8538 -- 44,499,394(+) CCTGA(A/C)TAGAA utr-variant-3-prime, intron-variant
rs13568 -- 44,499,506(+) CCAAA(A/T)ACCTT utr-variant-3-prime, intron-variant
rs13786 -- 44,500,051(+) TAGTT(A/C)ACTTT utr-variant-3-prime, intron-variant
rs15254 -- 44,497,554(+) TTTTT(G/T)AAGTT intron-variant

Relevant External Links for SERINC3 Gene

HapMap Linkage Disequilibrium report
SERINC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SERINC3 Gene

Disorders for SERINC3 Gene

No disorders were found for SERINC3 Gene.

No data available for UniProtKB/Swiss-Prot for SERINC3 Gene

Publications for SERINC3 Gene

  1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PMID: 10559794) Bossolasco M. … Mes-Masson A.-M. (Mol. Carcinog. 1999) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. (PMID: 16547497) Bossolasco M. … Mes-Masson A.M. (Oncogene 2006) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for SERINC3 Gene

  • antibodies-online peptides for SERINC3
  • antibodies-online antibodies for SERINC3
  • antibodies-online kits for SERINC3

Sources for SERINC3 Gene

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