Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERINC3 Gene

protein-coding   GIFtS: 54
GCID: GC20M043124

Serine Incorporator 3

(Previous name: tumor differentially expressed 1)
(Previous symbol: TDE1)
  Search for SERINC3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Incorporator 31 2     SBBI992
TDE11 2 3 5     TDE2
Tumor Differentially Expressed 11 2     TMS-12
Tumor Differentially Expressed Protein 12 3     Placental Transmembrane Protein (Mouse Testicular Tumor Differentially
Expressed)2
DIFF332 3     Transmembrane Protein SBBI992
AIGP12     Tumour Differentially Expressed 12

External Ids:    HGNC: 116991   Entrez Gene: 109552   Ensembl: ENSG000001328247   OMIM: 6071655   UniProtKB: Q135303   

Export aliases for SERINC3 gene to outside databases

Previous GC identifers: GC20M042559 GC20M039866


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERINC3 Gene: 
SERINC3 (serine incorporator 3) is a protein-coding gene. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
Function: May be involved in cellular transformation

Gene Wiki entry for SERINC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERINC3 gene promoter:
         Elk-1   LUN-1   LCR-F1   AREB6   MZF-1   E2F   E2F-1   Pax-4a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SERINC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERINC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

SERINC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043124:  view genomic region     (about GC identifiers)

Start:
43,124,862 bp from pter      End:
43,150,750 bp from pter
Size:
25,889 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530 (See protein sequence)
Recommended Name: Serine incorporator 3  
Size: 473 amino acids; 52580 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Sequence=AAD34641.1;
Type=Frameshift; Positions=321, 393, 407, 459;
Secondary accessions: O43717 Q9BR33

Explore the universe of human proteins at neXtProt for SERINC3: NX_Q13530

Explore proteomics data for SERINC3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13530

  • SERINC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERINC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006802.1  NP_945179.1  

    ENSEMBL proteins: 
     ENSP00000414197   ENSP00000340243   ENSP00000255175   ENSP00000440966  

    Human Recombinant Protein Products for SERINC3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SERINC3
    OriGene Protein Over-expression Lysate for SERINC3
    OriGene MassSpec for SERINC3 
    OriGene Custom Protein Services for SERINC3
    GenScript Custom Purified and Recombinant Proteins Services for SERINC3
    Novus Biologicals SERINC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERINC3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SERINC3 for ontologies           About GeneDecksing



    SERINC3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SERINC3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SERINC3
    GenScript Custom Superior Antibodies Services for SERINC3
    Novus Biologicals SERINC3 Antibodies
    Abcam antibodies for SERINC3
    Cloud-Clone Corp. Antibodies for SERINC3 
    ThermoFisher Antibodies for SERINC3
    LSBio Antibodies in human, mouse, rat for SERINC3 

    Assay Products for SERINC3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SERINC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SERINC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SERINC3 
    Cloud-Clone Corp. CLIAs for SERINC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005016 TMS_TDE

    Graphical View of Domain Structure for InterPro Entry Q13530

    ProtoNet protein and cluster: Q13530

    1 Blocks protein domain: IPB005016 TMS membrane protein/tumour differentially expressed protein

    UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
    Similarity: Belongs to the TDE1 family


    SERINC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERC3_HUMAN, Q13530
    Function: May be involved in cellular transformation

    Phenotypes:
         1 MGI phenotypic allele for Serinc3 (no phenotypes)


    SERINC3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERINC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERINC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERINC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERINC3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERINC3:
    hsa-mir-204 (MIRT005842)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERINC3
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SERINC3 (see all 20):
    hsa-miR-513a-5p hsa-miR-301a hsa-miR-340 hsa-miR-3133 hsa-miR-20b* hsa-miR-130b hsa-miR-412 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSERINC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERINC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SERINC3
    Sirion Biotech Customized adenovirus for overexpression of SERINC3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SERINC3 (see all 13)
    OriGene ORF clones in mouse, rat for SERINC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERINC3 (NM_006811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC3
    Sirion Biotech Customized lentivirus for stable overexpression of SERINC3 
                         Customized lentivirus expression plasmids for stable overexpression of SERINC3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SERINC3
    Search LifeMap BioReagents cell lines for SERINC3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERINC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/37 Interacting proteins for SERINC3 (Q135303 ENSP000002551754) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDELR2P339473, ENSP000002587394I2D: score=2 STRING: ENSP00000258739
    SURF4O152603, ENSP000003610574I2D: score=2 STRING: ENSP00000361057
    VDAC2P458803, ENSP000003616864I2D: score=2 STRING: ENSP00000361686
    PTPLAD1Q9P0353, ENSP000002618754I2D: score=2 STRING: ENSP00000261875
    XPO5Q9HAV43, ENSP000002653514I2D: score=2 STRING: ENSP00000265351
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERINC3 (SERC3)

    Search CenterWatch for drugs/clinical trials and news about SERINC3 / SERC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERINC3 gene (2 alternative transcripts): 
    NM_006811.2  NM_198941.1  

    Unigene Cluster for SERINC3:

    Serine incorporator 3
    Hs.272168  [show with all ESTs]
    Unigene Representative Sequence: NM_006811
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411544 ENST00000342374(uc002xmf.1 uc010ggs.1 uc010zwp.1)
    ENST00000468234 ENST00000255175(uc002xme.3) ENST00000541235
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERINC3
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SERINC3 (see all 20):
    hsa-miR-513a-5p hsa-miR-301a hsa-miR-340 hsa-miR-3133 hsa-miR-20b* hsa-miR-130b hsa-miR-412 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidSERINC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SERINC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC3
    Clone
    Products:
         
    OriGene clones in human, mouse for SERINC3 (see all 13)
    OriGene ORF clones in mouse, rat for SERINC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SERINC3 (NM_006811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC3
    Sirion Biotech Customized lentivirus for stable overexpression of SERINC3 
                         Customized lentivirus expression plasmids for stable overexpression of SERINC3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERINC3
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERINC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC3

    Additional mRNA sequence: 

    AF112227.1 AF153979.1 AK222923.1 AK295120.1 AK300618.1 AK309993.1 BC006088.1 U49188.1 

    24/25 DOTS entries (see all 25):

    DT.454945  DT.95270601  DT.100702738  DT.100852073  DT.92325328  DT.100852076  DT.95270593  DT.100829318 
    DT.95270578  DT.100852071  DT.95270596  DT.100852078  DT.100852081  DT.120837493  DT.92448907  DT.100044820 
    DT.40116277  DT.120837413  DT.120837419  DT.120837505  DT.92058288  DT.92448911  DT.92428113  DT.95270572 

    24/706 AceView cDNA sequences (see all 706):

    BQ893173 BI823785 AI697815 CB138901 AI095417 AI609627 AA480293 CR614932 
    AI680627 AA894918 AA053110 CF552583 CB996546 CR617136 BE858565 BI823429 
    AA707775 CB996545 CR591564 BM717317 AA468575 BQ001977 AI151172 CB988318 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                    -     -     -           -                                                                           
    SP2:                    -     -     -           -                       -                                                   
    SP3:                    -                       -                                                                           
    SP4:                                                                                                              -         
    SP5:                    -     -     -                                                                                       


    ECgene alternative splicing isoforms for SERINC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERINC3 expression in normal human tissues (normalized intensities)      SERINC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAATATAT
    SERINC3 Expression
    About this image


    SERINC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             ganglion/cranial/facial VII   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See SERINC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERINC3

    SOURCE GeneReport for Unigene cluster: Hs.272168

    UniProtKB/Swiss-Prot: SERC3_HUMAN, Q13530
    Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues
    compared with normal pulmonary tissues

        SABiosciences Expression via Pathway-Focused PCR Array including SERINC3: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SERINC3
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERINC3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERINC3 gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serinc31 , 5 serine incorporator 31, 5 82.34(n)1
    78.18(a)1
      2 (84.38 cM)5
    269431  NM_012032.41  NP_036162.31 
     1636232725 
    chicken
    (Gallus gallus)
    Aves SERINC31 serine incorporator 3 70.62(n)
    69.28(a)
      419196  NM_001006291.1  NP_001006291.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERINC36
    Uncharacterized protein
    71(a)
    1 ↔ 1
    4(144061184-144076294)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.12262 Transcribed sequence with weak similarity to protein more 73.64(n)    141991957 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005356831 serine incorporator 3-like 62.33(n)
    58.42(a)
      100535683  XM_003199409.1  XP_003199457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TMS16
    TMS1
    39(a)
    1 → many
    3L(16405822-16408486)
    worm
    (Caenorhabditis elegans)
    Secernentea R11H6.26
    Y57E12AL.16
    Protein Y57E12AL.1, isoform a
    43(a)
    42(a)
    many ↔ many
    many ↔ many
    V(14597939-14600091)
    V(7060809-7062817)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMS1(YDR105C)4 Vacuolar membrane protein of unknown function that more   --   4(666770-665349) 851682  NP_010390.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G161801 serinc-domain containing protein 48.13(n)
    34.91(a)
      838187  NM_001198079.1  NP_001185008.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07929001 hypothetical protein 48.21(n)
    37.41(a)
      4330983  NM_001054899.1  NP_001048364.1 


    ENSEMBL Gene Tree for SERINC3 (if available)
    TreeFam Gene Tree for SERINC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERINC3 gene
    SERINC42  SERINC12  SERINC52  SERINC22  
    4 SIMAP similar genes for SERINC3 using alignment to 5 protein entries:     SERC3_HUMAN (see all proteins):
    SERINC1    SERINC2    SERINC5    SERINC4

    SERINC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SERINC3
    PGOHUM00000249396


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 SNPs in SERINC3 are shown (see all 597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0143154
    ----see VAR_0143152 T A mis40--------
    rs61306261,2
    C,H--43124478(+) CACTAG/TGGATA 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs1446499351,2
    C--43124558(+) TAGAGA/GAGCAA 1 -- ds50010--------
    rs1487106831,2
    --43124594(+) AAACTA/TGGTTC 1 -- ds50010--------
    rs1902812441,2
    --43124597(+) CTAGGC/TTCCCA 1 -- ds50010--------
    rs1828471191,2
    --43124730(+) AGAACC/TCTTAA 1 -- ds50010--------
    rs413087011,2
    C--43124780(+) AACCAC/TAGGCA 1 -- ds50010--------
    rs1882063111,2
    --43124856(+) CCTTAC/GAGGCA 1 -- ds50010--------
    rs130438331,2
    C,H--43124910(+) TGTGGT/GTTCTA 1 -- ut314Minor allele frequency- G:0.00NS EA 416
    rs61037531,2
    H--43124941(+) ACATAG/AGCATG 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for SERINC3 (43124862 - 43150750 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SERINC3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERINC3
    DNA2.0 Custom Variant and Variant Library Synthesis for SERINC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SERINC3 for disorders           About MalaCards
    OMIM gene information: 607165    OMIM disorders: --


    SERINC3 for disorders           About GeneDecksing


    Export disorders for SERINC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERINC3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SERINC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PubMed id 10559794)1, 2, 3 Bossolasco M.... Mes-Masson A.-M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. A genome-wide association study of seasonal pattern ma nia identifies NF1A as a possible susceptibility gene for bipolar disorder. (PubMed id 22925353)1 Lee H.J....Kelsoe J.R. (2013)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    9. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. (PubMed id 16547497)1 Bossolasco M....Mes-Masson A.M. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10955 HGNC: 11699 AceView: TDE1 Ensembl:ENSG00000132824 euGenes: HUgn10955
    ECgene: SERINC3 H-InvDB: SERINC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERINC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERINC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERINC3 gene:
    Search GeneIP for patents involving SERINC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SERINC3
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SERINC3  
     OriGene qPCR primer pairs and template standards for SERINC3   OriGene Protein Over-expression Lysate for SERINC3  
     OriGene MassSpec something-or-other for SERINC3   OriGene clones in human, mouse for SERINC3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SERINC3   OriGene Purified Protein for SERINC3  
     OriGene ORF clones in mouse, rat for SERINC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SERINC3   OriGene Custom Protein Services for SERINC3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERINC3
     QIAGEN SeqTarget long-range PCR primers for resequencing SERINC3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERINC3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERINC3
     GenScript Custom Purified and Recombinant Proteins Services for SERINC3 GenScript cDNA clones with any tag delivered in your preferred vector for SERINC3
     GenScript Custom Assay Services for SERINC3 GenScript Custom Superior Antibodies Services for SERINC3
     GenScript Custom overexpressing Cell Line Services for SERINC3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SERINC3 promoter
     Search Chromatin IP Primers for SERINC3
     RT2 qPCR Primer Assay in human, mouse, rat SERINC3
     Search GNC Networks for SERINC3
     SABiosciences PCR Arrays including human, mouse, rat SERINC3
     Search Tocris compounds for SERINC3 (SERC3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SERINC3 antibodies
     SERINC3 lysates
     Antibodies for SERINC3
     See all of Abcam's Antibodies, Kits and Proteins for SERINC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SERINC3
     Antibodies for SERINC3
     ELISAs for SERINC3
     CLIAs for SERINC3
     Search LifeMap BioReagents cell lines for SERINC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC3
     SwitchGear 3'UTR luciferase reporter plasmids for SERINC3
     SwitchGear Promoter luciferase reporter plasmids for SERINC3
     ThermoFisher Antibodies for SERINC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SERINC3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERINC3
    Customized:
     lentivirus for stable overexpression of SERINC3
     lentivirus expression plasmids for stable overexpression of SERINC3
     adenovirus for overexpression of SERINC3
     LSBio Antibodies in human, mouse, rat for SERINC3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SERINC3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4