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Aliases for SERINC2 Gene

Aliases for SERINC2 Gene

  • Serine Incorporator 2 2 3 5
  • TDE2L 3 4
  • Tumor Differentially Expressed Protein 2-Like 4
  • Tumor Differentially Expressed Protein 2 3
  • Tumor Differentially Expressed 2-Like 2
  • PRO0899 3
  • FKSG84 3
  • TDE2 3

External Ids for SERINC2 Gene

Previous HGNC Symbols for SERINC2 Gene

  • TDE2L

Previous GeneCards Identifiers for SERINC2 Gene

  • GC01P031556
  • GC01P031659
  • GC01P031883
  • GC01P030003

Summaries for SERINC2 Gene

GeneCards Summary for SERINC2 Gene

SERINC2 (Serine Incorporator 2) is a Protein Coding gene. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

Additional gene information for SERINC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC2 Gene

Genomics for SERINC2 Gene

Regulatory Elements for SERINC2 Gene

Enhancers for SERINC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H031370 1.5 Ensembl ENCODE dbSUPER 38.8 -35.6 -35564 7 ARID4B ETS1 FOS ATF7 SP5 RFX3 GLIS1 NR2C1 KDM1A KLF1 SERINC2 FAM229A TSSK3 SNRNP40 TMEM39B DCDC2B TMEM234 FABP3 GC01M031352
GH01H031420 1.5 Ensembl ENCODE dbSUPER 37.6 +13.1 13144 3 HDGF PKNOX1 ATF1 ARID4B GLIS2 ZNF143 FOS ATF7 RUNX3 DEK SERINC2 FABP3 TINAGL1 LOC105378626 SNRNP40 LOC105378625
GH01H031412 1.3 ENCODE dbSUPER 36.6 +5.6 5645 5 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 GLIS2 ATF7 SP5 ZHX2 SERINC2 LOC105378626 TINAGL1 ENSG00000229044 LOC105378625
GH01H031443 1.5 Ensembl ENCODE dbSUPER 28.1 +35.5 35545 2 FOXA2 ATF1 MLX ARID4B YY1 SLC30A9 ZNF143 SP5 REST PPARG SERINC2 TINAGL1 LOC105378626 DCDC2B LOC105378625
GH01H031394 1.5 Ensembl ENCODE dbSUPER 26.8 -14.8 -14765 1 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF121 GLIS2 ZNF143 FOS ATF7 SERINC2 ENSG00000229044 LOC105378626 TINAGL1 LOC105378623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERINC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERINC2 Gene

Chromosome:
1
Start:
31,409,565 bp from pter
End:
31,434,680 bp from pter
Size:
25,116 bases
Orientation:
Plus strand

Genomic View for SERINC2 Gene

Genes around SERINC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC2 Gene

Proteins for SERINC2 Gene

  • Protein details for SERINC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SA4-SERC2_HUMAN
    Recommended name:
    Serine incorporator 2
    Protein Accession:
    Q96SA4
    Secondary Accessions:
    • A0AVB4
    • B4DJK5
    • B7Z567
    • B7ZAP2
    • E7EUZ9
    • Q86Y23

    Protein attributes for SERINC2 Gene

    Size:
    455 amino acids
    Molecular mass:
    50742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC2 Gene

Post-translational modifications for SERINC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC2 Gene

No data available for DME Specific Peptides for SERINC2 Gene

Domains & Families for SERINC2 Gene

Gene Families for SERINC2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SERINC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SA4

UniProtKB/Swiss-Prot:

SERC2_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC2: view

Function for SERINC2 Gene

Phenotypes From GWAS Catalog for SERINC2 Gene

Gene Ontology (GO) - Molecular Function for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC2: view
genes like me logo Genes that share phenotypes with SERINC2: view

Animal Model Products

CRISPR Products

miRNA for SERINC2 Gene

miRTarBase miRNAs that target SERINC2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERINC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC2 Gene

Localization for SERINC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC2 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SERINC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERINC2 Gene

Pathways & Interactions for SERINC2 Gene

genes like me logo Genes that share pathways with SERINC2: view

Gene Ontology (GO) - Biological Process for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0015825 L-serine transport IEA --
GO:1904219 positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA --
GO:1904222 positive regulation of serine C-palmitoyltransferase activity IEA --
genes like me logo Genes that share ontologies with SERINC2: view

No data available for SIGNOR curated interactions for SERINC2 Gene

Drugs & Compounds for SERINC2 Gene

No Compound Related Data Available

Transcripts for SERINC2 Gene

Unigene Clusters for SERINC2 Gene

Serine incorporator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERINC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11: - -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SERINC2 Gene

GeneLoc Exon Structure for
SERINC2
ECgene alternative splicing isoforms for
SERINC2

Expression for SERINC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERINC2 Gene

This gene is overexpressed in Liver (x8.0), Minor Salivary Gland (x4.9), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for SERINC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERINC2 Gene



Protein tissue co-expression partners for SERINC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERINC2 Gene:

SERINC2

SOURCE GeneReport for Unigene cluster for SERINC2 Gene:

Hs.270655

Evidence on tissue expression from TISSUES for SERINC2 Gene

  • Kidney(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SERINC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC2 Gene

Orthologs for SERINC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC2 33 34
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia SERINC2 33 34 34
  • 88.41 (n)
dog
(Canis familiaris)
Mammalia SERINC2 33 34
  • 87.24 (n)
rat
(Rattus norvegicus)
Mammalia Serinc2 33
  • 84.96 (n)
mouse
(Mus musculus)
Mammalia Serinc2 33 16 34
  • 84.89 (n)
oppossum
(Monodelphis domestica)
Mammalia SERINC2 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC2 33 34
  • 72.87 (n)
lizard
(Anolis carolinensis)
Reptilia SERINC2 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc2 33
  • 63.53 (n)
zebrafish
(Danio rerio)
Actinopterygii serinc2l 33 34
  • 66.15 (n)
serinc2 34
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TMS1 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 34
  • 40 (a)
ManyToMany
Y57E12AL.1 34
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
Species where no ortholog for SERINC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC2 Gene

ENSEMBL:
Gene Tree for SERINC2 (if available)
TreeFam:
Gene Tree for SERINC2 (if available)

Paralogs for SERINC2 Gene

Paralogs for SERINC2 Gene

(4) SIMAP similar genes for SERINC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SERINC2: view

Variants for SERINC2 Gene

Sequence variations from dbSNP and Humsavar for SERINC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000205693 -- 31,420,099(+) CCTTA(C/T)TCCAA intron-variant
rs1000791489 -- 31,410,185(+) ACATA(A/G)CTGCT intron-variant, utr-variant-5-prime
rs1000867736 -- 31,427,662(+) GCCTC(A/G)GACAT intron-variant
rs1000920091 -- 31,427,331(+) TTCAG(A/G)AAGTA intron-variant
rs1001032151 -- 31,432,735(+) GATTA(C/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC2 Gene

Variant ID Type Subtype PubMed ID
esv1004118 CNV insertion 20482838
esv1133300 CNV insertion 17803354
esv1676191 CNV insertion 17803354
esv21814 CNV gain 19812545
esv2746341 CNV deletion 23290073
esv2746352 CNV deletion 23290073
esv2758930 CNV loss 17122850
esv3577802 CNV loss 25503493
nsv509135 CNV insertion 20534489
nsv7712 CNV insertion 18451855
nsv950383 CNV deletion 24416366

Variation tolerance for SERINC2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC2 Gene

Human Gene Mutation Database (HGMD)
SERINC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC2 Gene

Disorders for SERINC2 Gene

Relevant External Links for SERINC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC2

No disorders were found for SERINC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC2 Gene

Publications for SERINC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Identification of TDE2 gene and its expression in non-small cell lung cancer. (PMID: 12949800) Player A … Jen J (International journal of cancer 2003) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SERINC2 Gene

Sources for SERINC2 Gene

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