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Aliases for SERINC2 Gene

Aliases for SERINC2 Gene

  • Serine Incorporator 2 2 3
  • TDE2L 3 4
  • Tumor Differentially Expressed Protein 2-Like 4
  • Tumor Differentially Expressed Protein 2 3
  • Tumor Differentially Expressed 2-Like 2
  • PRO0899 3
  • FKSG84 3
  • TDE2 3

External Ids for SERINC2 Gene

Previous HGNC Symbols for SERINC2 Gene

  • TDE2L

Previous GeneCards Identifiers for SERINC2 Gene

  • GC01P031556
  • GC01P031659
  • GC01P031883
  • GC01P030003

Summaries for SERINC2 Gene

GeneCards Summary for SERINC2 Gene

SERINC2 (Serine Incorporator 2) is a Protein Coding gene. An important paralog of this gene is SERINC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC2 Gene

Genomics for SERINC2 Gene

Regulatory Elements for SERINC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SERINC2 Gene

Start:
31,409,565 bp from pter
End:
31,434,680 bp from pter
Size:
25,116 bases
Orientation:
Plus strand

Genomic View for SERINC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERINC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC2 Gene

Proteins for SERINC2 Gene

  • Protein details for SERINC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SA4-SERC2_HUMAN
    Recommended name:
    Serine incorporator 2
    Protein Accession:
    Q96SA4
    Secondary Accessions:
    • A0AVB4
    • B4DJK5
    • B7Z567
    • B7ZAP2
    • E7EUZ9
    • Q86Y23

    Protein attributes for SERINC2 Gene

    Size:
    455 amino acids
    Molecular mass:
    50742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC2 Gene

Proteomics data for SERINC2 Gene at MOPED

Post-translational modifications for SERINC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SERINC2

No data available for DME Specific Peptides for SERINC2 Gene

Domains for SERINC2 Gene

Protein Domains for SERINC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SA4

UniProtKB/Swiss-Prot:

SERC2_HUMAN :
  • Q96SA4
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC2: view

No data available for Gene Families for SERINC2 Gene

Function for SERINC2 Gene

Gene Ontology (GO) - Molecular Function for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC2: view

Animal Model Products

CRISPR Products

miRNA for SERINC2 Gene

miRTarBase miRNAs that target SERINC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERINC2 Gene

Localization for SERINC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERINC2 Gene COMPARTMENTS Subcellular localization image for SERINC2 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SERINC2: view

Pathways for SERINC2 Gene

SuperPathways for SERINC2 Gene

No Data Available

Interacting Proteins for SERINC2 Gene

Gene Ontology (GO) - Biological Process for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0015825 L-serine transport IBA --
GO:0051347 positive regulation of transferase activity IEA --
genes like me logo Genes that share ontologies with SERINC2: view

No data available for Pathways by source for SERINC2 Gene

Transcripts for SERINC2 Gene

Unigene Clusters for SERINC2 Gene

Serine incorporator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERINC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8: -
SP9:
SP10: - - - - - - - -
SP11: - -

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SERINC2 Gene

GeneLoc Exon Structure for
SERINC2
ECgene alternative splicing isoforms for
SERINC2

Expression for SERINC2 Gene

mRNA expression in normal human tissues for SERINC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERINC2 Gene

This gene is overexpressed in Liver (8.0), Minor Salivary Gland (4.9), and Colon - Transverse (4.8).

Protein differential expression in normal tissues for SERINC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SERINC2 Gene

SOURCE GeneReport for Unigene cluster for SERINC2 Gene Hs.270655

genes like me logo Genes that share expressions with SERINC2: view

Expression partners for SERINC2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SERINC2 Gene

Orthologs for SERINC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERINC2 35
  • 88.41 (n)
  • 86.15 (a)
SERINC2 36
  • 87 (a)
OneToMany
SERINC2 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SERINC2 35
  • 87.24 (n)
  • 86.71 (a)
SERINC2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serinc2 35
  • 84.89 (n)
  • 86.89 (a)
Serinc2 16
Serinc2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERINC2 35
  • 98.59 (n)
  • 98.89 (a)
SERINC2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serinc2 35
  • 84.96 (n)
  • 86 (a)
oppossum
(Monodelphis domestica)
Mammalia SERINC2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC2 35
  • 72.87 (n)
  • 68.61 (a)
SERINC2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc2 35
  • 63.53 (n)
  • 63.53 (a)
zebrafish
(Danio rerio)
Actinopterygii serinc2l 35
  • 66.15 (n)
  • 62.28 (a)
serinc2 36
  • 59 (a)
OneToMany
serinc2l 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TMS1 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 36
  • 40 (a)
ManyToMany
Y57E12AL.1 36
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
Species with no ortholog for SERINC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC2 Gene

ENSEMBL:
Gene Tree for SERINC2 (if available)
TreeFam:
Gene Tree for SERINC2 (if available)

Paralogs for SERINC2 Gene

Paralogs for SERINC2 Gene

Selected SIMAP similar genes for SERINC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SERINC2: view

Variants for SERINC2 Gene

Sequence variations from dbSNP and Humsavar for SERINC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4233 -- 31,434,610(-) GGAAG(C/G/T)GGGCA utr-variant-3-prime
rs1018164 -- 31,409,483(+) TAAAT(G/T)CATCT upstream-variant-2KB
rs1039630 -- 31,408,625(+) ACATA(C/T)ACACT upstream-variant-2KB
rs1044177 -- 31,434,589(-) GGGGA(A/C/T)GTGAC utr-variant-3-prime
rs1127572 -- 31,425,889(+) AGGAG(G/T)GCGAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SERINC2 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
nsv7712 CNV Insertion 18451855
nsv509135 CNV Insertion 20534489
esv1004118 CNV Insertion 20482838
esv2746341 CNV Deletion 23290073
esv21814 CNV Gain 19812545
esv1133300 CNV Insertion 17803354
esv2746352 CNV Deletion 23290073
esv1676191 CNV Insertion 17803354

Relevant External Links for SERINC2 Gene

HapMap Linkage Disequilibrium report
SERINC2
Human Gene Mutation Database (HGMD)
SERINC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC2 Gene

Disorders for SERINC2 Gene

No disorders were found for SERINC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SERINC2 Gene

Publications for SERINC2 Gene

  1. Identification of TDE2 gene and its expression in non-small cell lung cancer. (PMID: 12949800) Player A. … Jen J. (Int. J. Cancer 2003) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for SERINC2 Gene

Sources for SERINC2 Gene

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