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Aliases for SERINC2 Gene

Aliases for SERINC2 Gene

  • Serine Incorporator 2 2 3 5
  • TDE2L 3 4
  • Tumor Differentially Expressed Protein 2-Like 4
  • Tumor Differentially Expressed Protein 2 3
  • Tumor Differentially Expressed 2-Like 2
  • PRO0899 3
  • FKSG84 3
  • TDE2 3

External Ids for SERINC2 Gene

Previous HGNC Symbols for SERINC2 Gene

  • TDE2L

Previous GeneCards Identifiers for SERINC2 Gene

  • GC01P031556
  • GC01P031659
  • GC01P031883
  • GC01P030003

Summaries for SERINC2 Gene

GeneCards Summary for SERINC2 Gene

SERINC2 (Serine Incorporator 2) is a Protein Coding gene. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC2 Gene

Genomics for SERINC2 Gene

Regulatory Elements for SERINC2 Gene

Enhancers for SERINC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F031381 1.1 Ensembl ENCODE 44.3 -27.5 -27484 1.9 SOX13 PKNOX1 GTF2E2 ZNF175 CEBPG ZNF644 RELA FOSL1 ZFHX2 ZNF766 SERINC2 ENSG00000229044 RNU6-40P TINAGL1 LOC105378626 GC01M031377 LOC105378623
GH01F031370 1.2 Ensembl ENCODE 38.8 -35.6 -35564 7.4 ARID4B ZNF48 ETS1 FOS ZNF263 SP5 MBD2 SMARCA4 RFX3 GLIS1 SERINC2 GC01M031352 FABP3
GH01F031420 1.2 Ensembl ENCODE 37.6 +13.1 13144 4.0 HDGF ATF1 PKNOX1 WRNIP1 ARID4B ZNF48 GLIS2 ZNF143 FOS DEK SERINC2 FABP3 LOC105378626 TINAGL1 SNRNP40 LOC105378625
GH01F031412 1.1 ENCODE 36.6 +5.6 5645 5.3 PKNOX1 MLX ARID4B DMAP1 YY1 ZNF207 SP5 JUNB ZHX2 MXD4 SERINC2 LOC105378626 TINAGL1 ENSG00000229044 LOC105378625
GH01F031305 1 Ensembl ENCODE 36.8 -103.3 -103265 2.1 BCOR SMARCA5 CTCF CBX3 JUN BHLHE40 CEBPB ZMYM3 NFXL1 EP300 SERINC2 ENSG00000229044 FABP3 SNRNP40 GC01P031311 ZCCHC17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERINC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERINC2 Gene

31,409,565 bp from pter
31,434,680 bp from pter
25,116 bases
Plus strand

Genomic View for SERINC2 Gene

Genes around SERINC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC2 Gene

Proteins for SERINC2 Gene

  • Protein details for SERINC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine incorporator 2
    Protein Accession:
    Secondary Accessions:
    • A0AVB4
    • B4DJK5
    • B7Z567
    • B7ZAP2
    • E7EUZ9
    • Q86Y23

    Protein attributes for SERINC2 Gene

    455 amino acids
    Molecular mass:
    50742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SERINC2 Gene


neXtProt entry for SERINC2 Gene

Post-translational modifications for SERINC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERINC2 Gene

No data available for DME Specific Peptides for SERINC2 Gene

Domains & Families for SERINC2 Gene

Protein Domains for SERINC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TDE1 family.
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC2: view

No data available for Gene Families for SERINC2 Gene

Function for SERINC2 Gene

Gene Ontology (GO) - Molecular Function for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004864 protein phosphatase inhibitor activity NAS --
GO:0005515 protein binding IPI --
GO:0008157 protein phosphatase 1 binding NAS --
GO:0015194 L-serine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SERINC2: view
genes like me logo Genes that share phenotypes with SERINC2: view

Animal Model Products

miRNA for SERINC2 Gene

miRTarBase miRNAs that target SERINC2

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC2 Gene

Localization for SERINC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC2 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IMP --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SERINC2: view

Pathways & Interactions for SERINC2 Gene

genes like me logo Genes that share pathways with SERINC2: view

Interacting Proteins for SERINC2 Gene

Gene Ontology (GO) - Biological Process for SERINC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001560 regulation of cell growth by extracellular stimulus TAS --
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0007015 actin filament organization IBA --
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with SERINC2: view

No data available for SIGNOR curated interactions for SERINC2 Gene

Transcripts for SERINC2 Gene

Unigene Clusters for SERINC2 Gene

Serine incorporator 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - -
SP5: - - - -
SP7: - - - - - -
SP8: -
SP10: - - - - - - - -
SP11: - -

ExUns: 16 ^ 17

Relevant External Links for SERINC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERINC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERINC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERINC2 Gene

This gene is overexpressed in Liver (x8.0), Minor Salivary Gland (x4.9), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for SERINC2 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SERINC2 Gene

Protein tissue co-expression partners for SERINC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERINC2 Gene:


SOURCE GeneReport for Unigene cluster for SERINC2 Gene:

genes like me logo Genes that share expression patterns with SERINC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SERINC2 Gene

Orthologs for SERINC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERINC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERINC2 34 35
  • 98.59 (n)
(Bos Taurus)
Mammalia SERINC2 34 35 35
  • 88.41 (n)
(Canis familiaris)
Mammalia SERINC2 34 35
  • 87.24 (n)
(Rattus norvegicus)
Mammalia Serinc2 34
  • 84.96 (n)
(Mus musculus)
Mammalia Serinc2 34 16 35
  • 84.89 (n)
(Monodelphis domestica)
Mammalia SERINC2 35
  • 79 (a)
(Gallus gallus)
Aves SERINC2 34 35
  • 72.87 (n)
(Anolis carolinensis)
Reptilia SERINC2 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc2 34
  • 63.53 (n)
(Danio rerio)
Actinopterygii serinc2l 34 35
  • 66.15 (n)
serinc2 35
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea R11H6.2 35
  • 40 (a)
Y57E12AL.1 35
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
-- 35
  • 40 (a)
Species where no ortholog for SERINC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC2 Gene

Gene Tree for SERINC2 (if available)
Gene Tree for SERINC2 (if available)

Paralogs for SERINC2 Gene

Paralogs for SERINC2 Gene

(4) SIMAP similar genes for SERINC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SERINC2: view

Variants for SERINC2 Gene

Sequence variations from dbSNP and Humsavar for SERINC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10047085 -- 31,429,571(+) GGATC(A/G)TGATT intron-variant
rs1018164 -- 31,409,483(+) TAAAT(G/T)CATCT upstream-variant-2KB
rs1039630 -- 31,408,625(+) ACATA(C/T)ACACT upstream-variant-2KB
rs1044177 -- 31,434,589(-) GGGGA(A/C/T)GTGAC utr-variant-3-prime
rs10454445 -- 31,426,837(+) GCCTG(A/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC2 Gene

Variant ID Type Subtype PubMed ID
nsv950383 CNV deletion 24416366
nsv7712 CNV insertion 18451855
nsv509135 CNV insertion 20534489
esv3577802 CNV loss 25503493
esv2758930 CNV loss 17122850
esv2746352 CNV deletion 23290073
esv2746341 CNV deletion 23290073
esv21814 CNV gain 19812545
esv1676191 CNV insertion 17803354
esv1133300 CNV insertion 17803354
esv1004118 CNV insertion 20482838

Variation tolerance for SERINC2 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC2 Gene

Disorders for SERINC2 Gene

Relevant External Links for SERINC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERINC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC2 Gene

Publications for SERINC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of TDE2 gene and its expression in non-small cell lung cancer. (PMID: 12949800) Player A. … Jen J. (Int. J. Cancer 2003) 2 3 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SERINC2 Gene

Sources for SERINC2 Gene

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