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SERINC1 Gene

protein-coding   GIFtS: 60
GCID: GC06M122807

Serine Incorporator 1

(Previous name: tumor differentially expressed 2)
(Previous symbol: TDE2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Incorporator 11 2     TMS22 5
TDE21 2 3     KIAA12533 5
Tumor Differentially Expressed 21 2     TMS-22
Tumor Differentially Expressed Protein 22 3     Tumor Differentially Expressed Protein 1-Like3
TDE1L2 3     

External Ids:    HGNC: 134641   Entrez Gene: 575152   Ensembl: ENSG000001118977   OMIM: 6145485   UniProtKB: Q9NRX53   

Export aliases for SERINC1 gene to outside databases

Previous GC identifer: GC06M120341


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERINC1 Gene:
SERINC1 (serine incorporator 1) is a protein-coding gene. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5
Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity)

Gene Wiki entry for SERINC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERINC1 gene promoter:
         GATA-3   Brachyury   GATA-1   YY1   Evi-1   GATA-2   CREB   FOXC1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERINC1 promoter sequence
   Search Chromatin IP Primers for SERINC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERINC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.32

SERINC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M122807:  view genomic region     (about GC identifiers)

Start:
122,764,493 bp from pter      End:
122,792,967 bp from pter
Size:
28,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5 (See protein sequence)
Recommended Name: Serine incorporator 1  
Size: 453 amino acids; 50495 Da
Subunit: Interacts with SPTLC1 (By similarity)
Sequence caution: Sequence=BAA86567.1; Type=Erroneous initiation;
Secondary accessions: B3KY69 E1P565 O75655 Q7Z2F5 Q8TAG1 Q9NTH8 Q9ULG7

Explore the universe of human proteins at neXtProt for SERINC1: NX_Q9NRX5

Explore proteomics data for SERINC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys343
  • Glycosylation2 at Asn298
  • Modification sites at PhosphoSitePlus

  • See SERINC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065806.1  
    ENSEMBL proteins: 
     ENSP00000342962  

    SERINC1 Human Recombinant Protein Products:

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    Novus Biologicals SERINC1 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SERINC1

     
    Search eBioscience for Proteins for SERINC1 

    SERINC1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SERINC1

    SERINC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SERINC1
    Cloud-Clone Corp. CLIAs for SERINC1
    Search eBioscience for ELISAs for SERINC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005016 TMS_TDE

    Graphical View of Domain Structure for InterPro Entry Q9NRX5

    ProtoNet protein and cluster: Q9NRX5

    1 Blocks protein domain: IPB005016 TMS membrane protein/tumour differentially expressed protein

    UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5
    Similarity: Belongs to the TDE1 family


    Find genes that share domains with SERINC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERC1_HUMAN, Q9NRX5
    Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0015194L-serine transmembrane transporter activity ISS--
         
    Find genes that share ontologies with SERINC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERINC1:
     Increased circadian period len  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Serinc1):
     growth/size/body 

    Find genes that share phenotypes with SERINC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERINC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERINC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERINC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERINC1

    miRNA
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    miRTarBase miRNAs that target SERINC1:
    hsa-mir-149-5p (MIRT045614), hsa-mir-92a-3p (MIRT049295)

    Block miRNA regulation of human, mouse, rat SERINC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERINC1 (see all 17):
    hsa-miR-579 hsa-miR-1226 hsa-miR-607 hsa-miR-520d-5p hsa-miR-429 hsa-miR-4275 hsa-miR-1273d hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSERINC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERINC1
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SERINC1 (NM_020755)
    Sino Biological Human cDNA Clone for SERINC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SERINC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SERC1_HUMAN, Q9NRX5: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SERINC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SERINC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid Metabolism0.42


    1 BioSystems Pathway for SERINC1
        Sphingolipid Metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERINC1
    Interactions:

        Search GeneGlobe Interaction Network for SERINC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SERINC1 (Q9NRX51, 3 ENSP000003429624) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX8Q067101, 3EBI-2683145,EBI-2683132 I2D: score=1 
    CREB3O438893I2D: score=1 
    TAF9Q165943I2D: score=1 
    TFCP2Q128003I2D: score=1 
    TMEM50AENSP000003634784STRING: ENSP00000363478
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006658phosphatidylserine metabolic process ISS--
    GO:0006665sphingolipid metabolic process ISS--
    GO:0008654phospholipid biosynthetic process IEA--
    GO:0015825L-serine transport ISS--
    GO:0051347positive regulation of transferase activity ISS--

    Find genes that share ontologies with SERINC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERINC1 (SERC1)

    Selected HMDB Compounds for SERINC1 (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Serine(-)-Serine (see all 26)56-45-1--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERINC1 gene: 
    NM_020755.2  

    Unigene Cluster for SERINC1:

    Serine incorporator 1
    Hs.146668  [show with all ESTs]
    Unigene Representative Sequence: AF087902
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339697(uc003pyy.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SERINC1 (see all 17):
    hsa-miR-579 hsa-miR-1226 hsa-miR-607 hsa-miR-520d-5p hsa-miR-429 hsa-miR-4275 hsa-miR-1273d hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSERINC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERINC1
    Predesigned siRNA for gene silencing in human, mouse, rat SERINC1
    Clone
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    OriGene clones in human, mouse for SERINC1 (see all 7)
    OriGene ORF clones in mouse, rat for SERINC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERINC1 (NM_020755)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC1
      QuantiTect SYBR Green Assays in human, mouse, rat SERINC1
      QuantiFast Probe-based Assays in human, mouse, rat SERINC1

    Additional mRNA sequence: 

    AB033079.1 AF087902.1 AF164794.1 AK075339.1 AL137261.1 AY358429.1 BC014412.1 BC028607.1 
    BC033029.2 

    Selected DOTS entries (see all 36):

    DT.97855833  DT.95182366  DT.100881460  DT.92457766  DT.121365465  DT.100881465  DT.100881507  DT.100881505 
    DT.100881462  DT.92457751  DT.100810392  DT.95232944  DT.91888583  DT.121365499  DT.92457756  DT.100881464 
    DT.121365497  DT.121365430  DT.121365448  DT.121365453  DT.121365454  DT.121365469  DT.121365475  DT.121365526 

    Selected AceView cDNA sequences (see all 632):

    AV709199 CA394763 AI422868 AL536148 AA946958 AI302419 AL534957 H47638 
    BF918669 AA773567 BM542132 T10566 BG682396 BU179606 BU159823 BQ722812 
    BX463606 T30549 AI274558 D60904 AA573354 AI520890 CB123003 AI968564 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SERINC1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
    SP1:                                                        -                                                     -     -                                   -   
    SP2:                                                        -                                         -     -     -     -                                       
    SP3:                                            -           -                                                                                                   
    SP4:                                                        -                 -                                                                                 
    SP5:                                                                                                  -     -     -     -                                       

    ExUns: 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SERINC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERINC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTGAAAT
    SERINC1 Expression
    About this image


    SERINC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    SERINC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERINC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146668
        Custom PCR Arrays for SERINC1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SERINC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERINC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERINC1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serinc11 , 5 serine incorporator 11, 5 89.92(n)1
    95.81(a)1
      10 (29.19 cM)5
    564421  NM_019760.31  NP_062734.11 
     575157745 
    chicken
    (Gallus gallus)
    Aves SERINC11 serine incorporator 1 79.65(n)
    86.95(a)
      421722  NM_001031074.1  NP_001026245.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERINC16
    serine incorporator 1
    86(a)
    1 ↔ 1
    1(182399345-182412659)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.99262 Xenopus laevis, Similar to likely ortholog of mouse more 78.56(n)    BC046718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02g012 wufd02g01 76.33(n)   325690  BC062825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TMS11 TMS1 50.75(n)
    45.74(a)
      39827  NM_140636.3  NP_648893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_R11H6.21 CELE_R11H6.2 52.35(n)
    46.19(a)
      179964  NM_074210.4  NP_506611.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMS11 TMS1 45.97(n)
    36.28(a)
      851682   NP_010390.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G061701 AT3G06170 44.36(n)
    33.58(a)
      819791  NM_111492.4  NP_187268.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g04541001 Os03g0454100 44.12(n)
    32.84(a)
      4333235  NM_001057011.1  NP_001050476.1 


    ENSEMBL Gene Tree for SERINC1 (if available)
    TreeFam Gene Tree for SERINC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERINC1 gene
    SERINC42  SERINC32  SERINC52  SERINC22  
    4 SIMAP similar genes for SERINC1 using alignment to 1 protein entry:     SERC1_HUMAN:
    SERINC3    SERINC2    SERINC5    SERINC4

    Find genes that share paralogs with SERINC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERINC1 (see all 612)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480657921,2
    C--122765733(+) AAAAGA/TACATT 1 -- int10--------
    rs743645541,2
    C,F--122765782(+) TCTGTG/AGAAGA 1 -- int13Minor allele frequency- A:0.08NA 124
    rs1417617641,2
    --122765900(+) ACTGAA/GGACTC 1 -- int10--------
    rs1808562601,2
    --122766360(+) ATCTAC/TATATT 1 -- ut310--------
    rs1860880871,2
    --122766370(+) TTCAAC/TTACAT 1 -- ut310--------
    rs11417871,2
    C--122766500(-) TGTGGA/GTTGCT 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs133711,2
    C,F,A,H--122766651(+) CTGTAC/TTTCAG 1 -- ut3127Minor allele frequency- T:0.22MN NS EA NA WA CSA 2352
    rs774314311,2
    C--122766784(+) TTTTT-/TTGTCTT 1 -- ut310--------
    rs412925801,2
    C,F--122766785(+) TATATA/G/TTTTTT 2 -- ut311EA 120
    rs1921941381,2
    --122766806(+) GTTGCC/GCAGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERINC1 (122764493 - 122792967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SERINC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2006e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SERINC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERINC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614548    OMIM disorders: --


    Find genes that share disorders with SERINC1           About GenesLikeMe

    Genetic Association Database (GAD): SERINC1
    Human Genome Epidemiology (HuGE) Navigator: SERINC1 (1 document)

    Export disorders for SERINC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERINC1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SERINC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Identification of a ubiquitous family of membrane proteins and their expression in mouse brain. (PubMed id 10637174)1, 3 Grossman T.R....Nelson N. (J. Exp. Biol. 2000)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57515 HGNC: 13464 AceView: TDE2 Ensembl:ENSG00000111897 euGenes: HUgn57515
    ECgene: SERINC1 H-InvDB: SERINC1

    (According to HUGE)
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    HUGE: KIAA1253

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERINC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERINC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERINC1 gene:
    Search GeneIP for patents involving SERINC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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