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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERINC1 Gene

protein-coding   GIFtS: 58
GCID: GC06M122807

Serine Incorporator 1

(Previous name: tumor differentially expressed 2)
(Previous symbol: TDE2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Incorporator 11 2     TMS-22
TDE21 2 3     TMS22
Tumor Differentially Expressed 21 2     KIAA12533
Tumor Differentially Expressed Protein 22 3     Tumor Differentially Expressed Protein 1-Like3
TDE1L2 3     

External Ids:    HGNC: 134641   Entrez Gene: 575152   Ensembl: ENSG000001118977   OMIM: 6145485   UniProtKB: Q9NRX53   

Export aliases for SERINC1 gene to outside databases

Previous GC identifer: GC06M120341


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SERINC1 Gene: 
SERINC1 (serine incorporator 1) is a protein-coding gene. Diseases associated with SERINC1 include astigmatism, and keratoconus, and among its related super-pathways are Sphingolipid metabolism. GO annotations related to this gene include protein binding and L-serine transmembrane transporter activity. An important paralog of this gene is SERINC4.

UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5
Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity)

Gene Wiki entry for SERINC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERINC1 gene promoter:
         GATA-3   Brachyury   GATA-1   YY1   Evi-1   GATA-2   CREB   FOXC1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERINC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERINC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERINC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.32

SERINC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERINC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M122807:  view genomic region     (about GC identifiers)

Start:
122,764,493 bp from pter      End:
122,907,269 bp from pter
Size:
142,777 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5 (See protein sequence)
Recommended Name: Serine incorporator 1  
Size: 453 amino acids; 50495 Da
Subunit: Interacts with SPTLC1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAA86567.1; Type=Erroneous initiation;
Secondary accessions: B3KY69 E1P565 O75655 Q7Z2F5 Q8TAG1 Q9NTH8 Q9ULG7

Explore the universe of human proteins at neXtProt for SERINC1: NX_Q9NRX5

Explore proteomics data for SERINC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRX5

  • SERINC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERINC1 Protein Expression
    REFSEQ proteins: NP_065806.1  
    ENSEMBL proteins: 
     ENSP00000357439   ENSP00000342962  

    Human Recombinant Protein Products for SERINC1: 
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    Novus Biologicals SERINC1 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SERINC1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SERINC1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SERINC1 
    Cloud-Clone Corp. CLIAs for SERINC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005016 TMS_TDE

    Graphical View of Domain Structure for InterPro Entry Q9NRX5

    ProtoNet protein and cluster: Q9NRX5

    1 Blocks protein domain: IPB005016 TMS membrane protein/tumour differentially expressed protein

    UniProtKB/Swiss-Prot: SERC1_HUMAN, Q9NRX5
    Similarity: Belongs to the TDE1 family


    SERINC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SERC1_HUMAN, Q9NRX5
    Function: Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0015194L-serine transmembrane transporter activity ISS--
         
    SERINC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SERINC1:
     Increased circadian period len  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Serinc1):
     growth/size 

    SERINC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERINC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERINC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERINC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERINC1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERINC1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SERINC1 (see all 17):
    hsa-miR-579 hsa-miR-1226 hsa-miR-607 hsa-miR-520d-5p hsa-miR-429 hsa-miR-4275 hsa-miR-1273d hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSERINC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SERINC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid Metabolism0.42


    1 BioSystems Pathway for SERINC1
        Sphingolipid Metabolism



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERINC1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/9 Interacting proteins for SERINC1 (Q9NRX51, 3 ENSP000003429624) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAX8Q067101, 3EBI-2683145,EBI-2683132 I2D: score=1 
    AK6Q165943I2D: score=1 
    TAF9Q165943I2D: score=1 
    CREB3O438893I2D: score=1 
    TFCP2Q128003I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006658phosphatidylserine metabolic process ISS--
    GO:0006665sphingolipid metabolic process ISS--
    GO:0008654phospholipid biosynthetic process IEA--
    GO:0015825L-serine transport ISS--
    GO:0051347positive regulation of transferase activity ISS--

    SERINC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERINC1 (SERC1)

    10/125 HMDB Compounds for SERINC1 (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Serine(-)-Serine (see all 26)56-45-1--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----

    Search CenterWatch for drugs/clinical trials and news about SERINC1 / SERC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERINC1 gene: 
    NM_020755.2  

    Unigene Cluster for SERINC1:

    Serine incorporator 1
    Hs.146668  [show with all ESTs]
    Unigene Representative Sequence: AF087902
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368454 ENST00000339697(uc003pyy.1)
    miRNA
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    hsa-miR-579 hsa-miR-1226 hsa-miR-607 hsa-miR-520d-5p hsa-miR-429 hsa-miR-4275 hsa-miR-1273d hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSERINC1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERINC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERINC1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERINC1

    Additional mRNA sequence: 

    AB033079.1 AF087902.1 AF164794.1 AK075339.1 AL137261.1 AY358429.1 BC014412.1 BC028607.1 
    BC033029.2 

    24/36 DOTS entries (see all 36):

    DT.97855833  DT.95182366  DT.100881460  DT.92457766  DT.121365465  DT.100881465  DT.100881507  DT.100881505 
    DT.100881462  DT.92457751  DT.100810392  DT.95232944  DT.91888583  DT.121365499  DT.92457756  DT.100881464 
    DT.121365497  DT.121365430  DT.121365448  DT.121365453  DT.121365454  DT.121365469  DT.121365475  DT.121365526 

    24/632 AceView cDNA sequences (see all 632):

    BU179606 AI520890 BX383349 AA573354 D60904 CB123003 AI274558 AA719677 
    CD514976 AA582675 CB215709 AI168110 BE677548 AF087902 AI089819 AW058255 
    AA788657 AI040812 AA485710 N73944 AI080014 R62562 CD514701 BP352957 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SERINC1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
    SP1:                                                        -                                                     -     -                                   -   
    SP2:                                                        -                                         -     -     -     -                                       
    SP3:                                            -           -                                                                                                   
    SP4:                                                        -                 -                                                                                 
    SP5:                                                                                                  -     -     -     -                                       

    ExUns: 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SERINC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERINC1 expression in normal human tissues (normalized intensities)      SERINC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTGAAAT
    SERINC1 Expression
    About this image


    SERINC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See SERINC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERINC1

    SOURCE GeneReport for Unigene cluster: Hs.146668
        SABiosciences Custom PCR Arrays for SERINC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERINC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERINC1 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serinc11 , 5 serine incorporator 11, 5 89.92(n)1
    95.81(a)1
      10 (29.19 cM)5
    564421  NM_019760.31  NP_062734.11 
     575157745 
    chicken
    (Gallus gallus)
    Aves SERINC11 serine incorporator 1 79.65(n)
    86.95(a)
      421722  NM_001031074.1  NP_001026245.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERINC16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    1(182399345-182412659)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.99262 Xenopus laevis, Similar to likely ortholog of mouse more 78.56(n)    BC046718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02g012 wufd02g01 76.33(n)   325690  BC062825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TMS11 CG4672-PA 50.79(n)
    45.84(a)
      39827  NM_140636.2  NP_648893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_R11H6.21 Protein R11H6.2 52.33(n)
    45.54(a)
      179964  NM_074210.3  NP_506611.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMS11 Tms1p 45.25(n)
    35.98(a)
      851682   NP_010390.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G061701 Serinc-domain containing serine and sphingolipid biosynthesis more 44.03(n)
    33.33(a)
      819791  NM_111492.4  NP_187268.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g04541001 hypothetical protein 43.74(n)
    31.46(a)
      4333235  NM_001057011.1  NP_001050476.1 


    ENSEMBL Gene Tree for SERINC1 (if available)
    TreeFam Gene Tree for SERINC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SERINC1 gene
    SERINC42  SERINC32  SERINC52  SERINC22  
    4 SIMAP similar genes for SERINC1 using alignment to 1 protein entry:     SERC1_HUMAN:
    SERINC3    SERINC2    SERINC5    SERINC4

    SERINC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/612 SNPs in SERINC1 are shown (see all 612)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480657921,2
    C--122765733(+) AAAAGA/TACATT 1 -- int10--------
    rs743645541,2
    C,F--122765782(+) TCTGTG/AGAAGA 1 -- int13Minor allele frequency- A:0.08NA 124
    rs1417617641,2
    --122765900(+) ACTGAA/GGACTC 1 -- int10--------
    rs1808562601,2
    --122766360(+) ATCTAC/TATATT 1 -- ut310--------
    rs1860880871,2
    --122766370(+) TTCAAC/TTACAT 1 -- ut310--------
    rs11417871,2
    C--122766500(-) TGTGGA/GTTGCT 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs133711,2
    C,F,A,H--122766651(+) CTGTAC/TTTCAG 1 -- ut3127Minor allele frequency- T:0.22MN NS EA NA WA CSA 2352
    rs774314311,2
    C--122766784(+) TTTTT-/TTGTCTT 1 -- ut310--------
    rs412925801,2
    C,F--122766785(+) TATATA/G/TTTTTT 2 -- ut311EA 120
    rs1921941381,2
    --122766806(+) GTTGCC/GCAGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SERINC1 (122764493 - 122907269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SERINC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2006e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614548    OMIM disorders: --

    4 diseases for SERINC1:    About MalaCards
    astigmatism    keratoconus    cleft lip    myopia


    SERINC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERINC1
    Human Genome Epidemiology (HuGE) Navigator: SERINC1 (1 document)

    Export disorders for SERINC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERINC1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SERINC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Identification of a ubiquitous family of membrane proteins and their expression in mouse brain. (PubMed id 10637174)1, 3 Grossman T.R....Nelson N. (2000)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57515 HGNC: 13464 AceView: TDE2 Ensembl:ENSG00000111897 euGenes: HUgn57515
    ECgene: SERINC1 H-InvDB: SERINC1

    (According to HUGE)
    About This Section
    HUGE: KIAA1253

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERINC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SERINC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERINC1 gene:
    Search GeneIP for patents involving SERINC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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