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Aliases for SERINC1 Gene

Aliases for SERINC1 Gene

  • Serine Incorporator 1 2 3 5
  • Tumor Differentially Expressed Protein 2 3 4
  • TDE1L 3 4
  • TDE2 3 4
  • Tumor Differentially Expressed Protein 1-Like 4
  • Tumor Differentially Expressed 2 2
  • KIAA1253 4
  • TMS-2 3
  • TMS2 3

External Ids for SERINC1 Gene

Previous HGNC Symbols for SERINC1 Gene

  • TDE2

Previous GeneCards Identifiers for SERINC1 Gene

  • GC06M122807
  • GC06M120341

Summaries for SERINC1 Gene

GeneCards Summary for SERINC1 Gene

SERINC1 (Serine Incorporator 1) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC2.

UniProtKB/Swiss-Prot for SERINC1 Gene

  • Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Gene Wiki entry for SERINC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC1 Gene

Genomics for SERINC1 Gene

Regulatory Elements for SERINC1 Gene

Promoters for SERINC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERINC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERINC1 Gene

Chromosome:
6
Start:
122,443,348 bp from pter
End:
122,471,822 bp from pter
Size:
28,475 bases
Orientation:
Minus strand

Genomic View for SERINC1 Gene

Genes around SERINC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC1 Gene

Proteins for SERINC1 Gene

  • Protein details for SERINC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX5-SERC1_HUMAN
    Recommended name:
    Serine incorporator 1
    Protein Accession:
    Q9NRX5
    Secondary Accessions:
    • B3KY69
    • E1P565
    • O75655
    • Q7Z2F5
    • Q8TAG1
    • Q9NTH8
    • Q9ULG7

    Protein attributes for SERINC1 Gene

    Size:
    453 amino acids
    Molecular mass:
    50495 Da
    Quaternary structure:
    • Interacts with SPTLC1.
    SequenceCaution:
    • Sequence=BAA86567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERINC1 Gene

Proteomics data for SERINC1 Gene at MOPED

Post-translational modifications for SERINC1 Gene

Other Protein References for SERINC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SERINC1

No data available for DME Specific Peptides for SERINC1 Gene

Domains & Families for SERINC1 Gene

Protein Domains for SERINC1 Gene

Suggested Antigen Peptide Sequences for SERINC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX5

UniProtKB/Swiss-Prot:

SERC1_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC1: view

No data available for Gene Families for SERINC1 Gene

Function for SERINC1 Gene

Molecular function for SERINC1 Gene

UniProtKB/Swiss-Prot Function:
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
genes like me logo Genes that share phenotypes with SERINC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC1

CRISPR Products

miRNA for SERINC1 Gene

miRTarBase miRNAs that target SERINC1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC1 Gene

Localization for SERINC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERINC1 Gene COMPARTMENTS Subcellular localization image for SERINC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0016021 integral component of membrane IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERINC1: view

Pathways & Interactions for SERINC1 Gene

SuperPathways for SERINC1 Gene

Superpath Contained pathways
1 Sphingolipid metabolism
genes like me logo Genes that share pathways with SERINC1: view

Pathways by source for SERINC1 Gene

1 BioSystems pathway for SERINC1 Gene

Interacting Proteins for SERINC1 Gene

Gene Ontology (GO) - Biological Process for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process IEA --
GO:0015825 L-serine transport IEA,ISS --
GO:1904219 positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA,ISS --
GO:1904222 positive regulation of serine C-palmitoyltransferase activity IEA,ISS --
genes like me logo Genes that share ontologies with SERINC1: view

No data available for SIGNOR curated interactions for SERINC1 Gene

Drugs & Compounds for SERINC1 Gene

(1) Drugs for SERINC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist 0

(124) Additional Compounds for SERINC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC1: view

Transcripts for SERINC1 Gene

mRNA/cDNA for SERINC1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(632) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERINC1 Gene

Serine incorporator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c · 11d · 11e · 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SERINC1 Gene

GeneLoc Exon Structure for
SERINC1
ECgene alternative splicing isoforms for
SERINC1

Expression for SERINC1 Gene

mRNA expression in normal human tissues for SERINC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC1 Gene

This gene is overexpressed in Adrenal (51.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERINC1 Gene



SOURCE GeneReport for Unigene cluster for SERINC1 Gene Hs.146668

genes like me logo Genes that share expression patterns with SERINC1: view

Protein tissue co-expression partners for SERINC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERINC1 Gene

Orthologs for SERINC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERINC1 35
  • 93.3 (n)
  • 97.57 (a)
-- 36
  • 91 (a)
OneToMany
SERINC1 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SERINC1 35
  • 93.01 (n)
  • 98.23 (a)
SERINC1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serinc1 35
  • 89.92 (n)
  • 95.81 (a)
Serinc1 16
Serinc1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERINC1 35
  • 99.71 (n)
  • 100 (a)
SERINC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serinc1 35
  • 89.92 (n)
  • 96.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC1 35
  • 79.65 (n)
  • 86.95 (a)
SERINC1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc1 35
  • 77.9 (n)
  • 85.59 (a)
Str.2375 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9926 35
zebrafish
(Danio rerio)
Actinopterygii serinc1 35
  • 72.52 (n)
  • 80.22 (a)
wufd02g01 35
serinc1 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4299 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002569 35
  • 53.09 (n)
  • 51.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 35
  • 50.75 (n)
  • 45.74 (a)
TMS1 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_R11H6.2 35
  • 52.35 (n)
  • 46.19 (a)
R11H6.2 36
  • 43 (a)
ManyToMany
Y57E12AL.1 36
  • 43 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR100W 35
  • 45.24 (n)
  • 37.53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11935g 35
  • 46.72 (n)
  • 38.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 35
  • 45.97 (n)
  • 36.28 (a)
TMS1 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06170 35
  • 44.36 (n)
  • 33.58 (a)
rice
(Oryza sativa)
Liliopsida Os03g0454100 35
  • 44.12 (n)
  • 32.84 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4846 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07986 35
  • 45.49 (n)
  • 38.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB1A10.07c 35
  • 46.43 (n)
  • 34.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for SERINC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC1 Gene

ENSEMBL:
Gene Tree for SERINC1 (if available)
TreeFam:
Gene Tree for SERINC1 (if available)

Paralogs for SERINC1 Gene

Paralogs for SERINC1 Gene

(4) SIMAP similar genes for SERINC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SERINC1: view

Variants for SERINC1 Gene

Sequence variations from dbSNP and Humsavar for SERINC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs13210569 - 122,452,052(+) TGATA(A/C)CAAGG reference, missense
rs13210446 - 122,452,001(+) AAAGA(A/C)CAGGA reference, missense
rs17260829 - 122,451,974(+) ACAAC(C/T)GGCTG reference, missense
rs12524 -- 122,444,803(+) CAATA(A/G)TGGCC utr-variant-3-prime
rs13371 -- 122,443,881(+) CTGTA(C/T)TTCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERINC1 Gene

Variant ID Type Subtype PubMed ID
dgv2006e1 CNV Complex 17122850

Variation tolerance for SERINC1 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC1 Gene

HapMap Linkage Disequilibrium report
SERINC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC1 Gene

Disorders for SERINC1 Gene

Relevant External Links for SERINC1

Genetic Association Database (GAD)
SERINC1
Human Genome Epidemiology (HuGE) Navigator
SERINC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC1

No disorders were found for SERINC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC1 Gene

Publications for SERINC1 Gene

  1. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 48 67
  2. Identification of a ubiquitous family of membrane proteins and their expression in mouse brain. (PMID: 10637174) Grossman T.R. … Nelson N. (J. Exp. Biol. 2000) 2 3
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SERINC1 Gene

Sources for SERINC1 Gene

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