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Aliases for SERINC1 Gene

Aliases for SERINC1 Gene

  • Serine Incorporator 1 2 3 5
  • Tumor Differentially Expressed Protein 2 3 4
  • TDE1L 3 4
  • TDE2 3 4
  • Tumor Differentially Expressed Protein 1-Like 4
  • Tumor Differentially Expressed 2 2
  • KIAA1253 4
  • TMS-2 3
  • TMS2 3

External Ids for SERINC1 Gene

Previous HGNC Symbols for SERINC1 Gene

  • TDE2

Previous GeneCards Identifiers for SERINC1 Gene

  • GC06M122807
  • GC06M120341

Summaries for SERINC1 Gene

GeneCards Summary for SERINC1 Gene

SERINC1 (Serine Incorporator 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC3.

UniProtKB/Swiss-Prot for SERINC1 Gene

  • Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Gene Wiki entry for SERINC1 Gene

Additional gene information for SERINC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC1 Gene

Genomics for SERINC1 Gene

Regulatory Elements for SERINC1 Gene

Enhancers for SERINC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H122609 1 ENCODE 11 -138.9 -138869 2 PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 SP3 SP5 ZNF610 ZSCAN16 SERINC1 HSF2 SMPDL3A PIR47029 ENSG00000272472
GH06H122530 0.7 ENCODE 11.6 -58.8 -58829 0 CTCF ZNF654 ZNF680 KLF6 TRIM22 REST ZNF2 RAD21 CC2D1A KLF16 SERINC1 ENSG00000277408 ENSG00000279114
GH06H122620 0.7 ENCODE 10.9 -149.5 -149495 1 FOXA2 CTBP1 GATA3 ZNF366 FOSL2 FOS NFE2 TCF7L2 SMARCE1 HLF SERINC1 ENSG00000272472 PIR47029
GH06H122644 0.4 ENCODE 10.5 -173.8 -173808 1 ZNF792 ZIC2 SERINC1 PKIB ENSG00000272472 RN7SL564P
GH06H122832 1 FANTOM5 ENCODE 3.9 -361.4 -361359 0 OSR2 POLR2A ZEB2 ATF7 ZNF843 WT1 ATF2 ZNF18 FABP7 SMPDL3A PKIB SERINC1 CLVS2 GC06M122860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERINC1 on UCSC Golden Path with GeneCards custom track

Promoters for SERINC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202058 522 2601 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SP3

Genomic Location for SERINC1 Gene

Chromosome:
6
Start:
122,443,348 bp from pter
End:
122,471,822 bp from pter
Size:
28,475 bases
Orientation:
Minus strand

Genomic View for SERINC1 Gene

Genes around SERINC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC1 Gene

Proteins for SERINC1 Gene

  • Protein details for SERINC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX5-SERC1_HUMAN
    Recommended name:
    Serine incorporator 1
    Protein Accession:
    Q9NRX5
    Secondary Accessions:
    • B3KY69
    • E1P565
    • O75655
    • Q7Z2F5
    • Q8TAG1
    • Q9NTH8
    • Q9ULG7

    Protein attributes for SERINC1 Gene

    Size:
    453 amino acids
    Molecular mass:
    50495 Da
    Quaternary structure:
    • Interacts with SPTLC1.
    SequenceCaution:
    • Sequence=BAA86567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERINC1 Gene

Post-translational modifications for SERINC1 Gene

  • Ubiquitination at isoforms=343
  • Glycosylation at Asn298
  • Modification sites at PhosphoSitePlus

Other Protein References for SERINC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERINC1 Gene

Domains & Families for SERINC1 Gene

Gene Families for SERINC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for SERINC1 Gene

Suggested Antigen Peptide Sequences for SERINC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX5

UniProtKB/Swiss-Prot:

SERC1_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC1: view

Function for SERINC1 Gene

Molecular function for SERINC1 Gene

UniProtKB/Swiss-Prot Function:
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Phenotypes From GWAS Catalog for SERINC1 Gene

Gene Ontology (GO) - Molecular Function for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0015194 L-serine transmembrane transporter activity IBA --
GO:0019899 enzyme binding IEA --
GO:0030674 protein binding, bridging IEA,ISS --
genes like me logo Genes that share ontologies with SERINC1: view
genes like me logo Genes that share phenotypes with SERINC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC1

CRISPR Products

miRNA for SERINC1 Gene

miRTarBase miRNAs that target SERINC1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERINC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC1 Gene

Localization for SERINC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SERINC1: view

Pathways & Interactions for SERINC1 Gene

genes like me logo Genes that share pathways with SERINC1: view

Pathways by source for SERINC1 Gene

Gene Ontology (GO) - Biological Process for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006658 phosphatidylserine metabolic process ISS --
GO:0006665 sphingolipid metabolic process ISS --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0015825 L-serine transport IEA --
genes like me logo Genes that share ontologies with SERINC1: view

No data available for SIGNOR curated interactions for SERINC1 Gene

Drugs & Compounds for SERINC1 Gene

(1) Drugs for SERINC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist Weak endogenous glycine receptor agonist 0

(124) Additional Compounds for SERINC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC1: view

Transcripts for SERINC1 Gene

mRNA/cDNA for SERINC1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(632) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERINC1 Gene

Serine incorporator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SERINC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c · 11d · 11e · 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SERINC1 Gene

GeneLoc Exon Structure for
SERINC1
ECgene alternative splicing isoforms for
SERINC1

Expression for SERINC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC1 Gene

This gene is overexpressed in Adrenal (51.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERINC1 Gene



Protein tissue co-expression partners for SERINC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERINC1 Gene:

SERINC1

SOURCE GeneReport for Unigene cluster for SERINC1 Gene:

Hs.146668

Evidence on tissue expression from TISSUES for SERINC1 Gene

  • Nervous system(5)
  • Kidney(4.5)
  • Adrenal gland(4.4)
  • Liver(4.4)
  • Pancreas(3.7)
  • Skin(3.5)
  • Lung(3.3)
  • Blood(3)
  • Spleen(2.5)
  • Muscle(2.3)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with SERINC1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC1 Gene

Orthologs for SERINC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC1 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia SERINC1 33 34
  • 93.3 (n)
-- 34
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SERINC1 33 34
  • 93.01 (n)
mouse
(Mus musculus)
Mammalia Serinc1 33 16 34
  • 89.92 (n)
rat
(Rattus norvegicus)
Mammalia Serinc1 33
  • 89.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC1 33 34
  • 79.65 (n)
lizard
(Anolis carolinensis)
Reptilia SERINC1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc1 33
  • 77.9 (n)
Str.2375 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9926 33
zebrafish
(Danio rerio)
Actinopterygii serinc1 33 34
  • 72.52 (n)
wufd02g01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4299 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002569 33
  • 53.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 33 34
  • 50.75 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_R11H6.2 33
  • 52.35 (n)
R11H6.2 34
  • 43 (a)
ManyToMany
Y57E12AL.1 34
  • 43 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11935g 33
  • 46.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 34 33
  • 45.97 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR100W 33
  • 45.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06170 33
  • 44.36 (n)
rice
(Oryza sativa)
Liliopsida Os03g0454100 33
  • 44.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB1A10.07c 33
  • 46.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07986 33
  • 45.49 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4846 33
Species where no ortholog for SERINC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC1 Gene

ENSEMBL:
Gene Tree for SERINC1 (if available)
TreeFam:
Gene Tree for SERINC1 (if available)

Paralogs for SERINC1 Gene

Paralogs for SERINC1 Gene

(4) SIMAP similar genes for SERINC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SERINC1: view

Variants for SERINC1 Gene

Sequence variations from dbSNP and Humsavar for SERINC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000075403 -- 122,455,066(+) TAAGG(C/T)TAGTT intron-variant
rs1000111374 -- 122,472,984(+) GCACG(C/T)GCATG intron-variant, upstream-variant-2KB
rs1000409605 -- 122,447,776(+) ACCCA(A/G)TAAAG intron-variant
rs1000460401 -- 122,448,085(+) CCTAA(C/T)GACAG intron-variant
rs1000548140 -- 122,466,424(+) GTGAT(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC1 Gene

Variant ID Type Subtype PubMed ID
esv2759467 CNV loss 17122850
nsv1018215 CNV loss 25217958
nsv1161448 CNV duplication 26073780

Variation tolerance for SERINC1 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC1 Gene

Disorders for SERINC1 Gene

Relevant External Links for SERINC1

Genetic Association Database (GAD)
SERINC1
Human Genome Epidemiology (HuGE) Navigator
SERINC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERINC1

No disorders were found for SERINC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC1 Gene

Publications for SERINC1 Gene

  1. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 45 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for SERINC1 Gene

Sources for SERINC1 Gene

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