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Aliases for SERINC1 Gene

Aliases for SERINC1 Gene

  • Serine Incorporator 1 2 3 5
  • Tumor Differentially Expressed Protein 2 3 4
  • TDE1L 3 4
  • TDE2 3 4
  • Tumor Differentially Expressed Protein 1-Like 4
  • Tumor Differentially Expressed 2 2
  • KIAA1253 4
  • TMS-2 3
  • TMS2 3

External Ids for SERINC1 Gene

Previous HGNC Symbols for SERINC1 Gene

  • TDE2

Previous GeneCards Identifiers for SERINC1 Gene

  • GC06M122807
  • GC06M120341

Summaries for SERINC1 Gene

GeneCards Summary for SERINC1 Gene

SERINC1 (Serine Incorporator 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC3.

UniProtKB/Swiss-Prot for SERINC1 Gene

  • Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Gene Wiki entry for SERINC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC1 Gene

Genomics for SERINC1 Gene

Regulatory Elements for SERINC1 Gene

Enhancers for SERINC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F122530 0.2 ENCODE 11.6 -58.8 -58829 0.1 CTCF ZNF654 ZNF680 KLF6 WRNIP1 TRIM22 REST ZNF2 RAD21 KLF16 SERINC1 ENSG00000277408 ENSG00000279114
GH06F122609 0.6 ENCODE 11 -138.9 -138869 2.6 PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 SP3 SP5 JUNB ZNF610 SERINC1 HSF2 SMPDL3A PIR47029 ENSG00000272472
GH06F122620 0.2 ENCODE 10.9 -149.5 -149495 1.6 HLF DPF2 ZNF217 OSR2 MBD2 GATA3 CTBP1 JUND ZNF366 NFE2 SERINC1 ENSG00000272472 PIR47029
GH06F122644 0.5 ENCODE 10.5 -173.8 -173808 1.6 SCRT1 ZNF792 ZIC2 ZNF652 SERINC1 PKIB ENSG00000272472 RN7SL564P
GH06F122832 0.7 FANTOM5 ENCODE 3.9 -361.4 -361359 0.8 OSR2 SMARCA4 POLR2A ZEB2 ZNF843 WT1 ATF2 ZNF18 FABP7 SMPDL3A PKIB SERINC1 CLVS2 GC06M122860
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SERINC1 on UCSC Golden Path with GeneCards custom track

Promoters for SERINC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SERINC1 Gene

122,443,348 bp from pter
122,471,822 bp from pter
28,475 bases
Minus strand

Genomic View for SERINC1 Gene

Genes around SERINC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC1 Gene

Proteins for SERINC1 Gene

  • Protein details for SERINC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine incorporator 1
    Protein Accession:
    Secondary Accessions:
    • B3KY69
    • E1P565
    • O75655
    • Q7Z2F5
    • Q8TAG1
    • Q9NTH8
    • Q9ULG7

    Protein attributes for SERINC1 Gene

    453 amino acids
    Molecular mass:
    50495 Da
    Quaternary structure:
    • Interacts with SPTLC1.
    • Sequence=BAA86567.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SERINC1 Gene

Post-translational modifications for SERINC1 Gene

Other Protein References for SERINC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SERINC1 Gene

Domains & Families for SERINC1 Gene

Protein Domains for SERINC1 Gene

Suggested Antigen Peptide Sequences for SERINC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TDE1 family.
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC1: view

No data available for Gene Families for SERINC1 Gene

Function for SERINC1 Gene

Molecular function for SERINC1 Gene

UniProtKB/Swiss-Prot Function:
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.

Gene Ontology (GO) - Molecular Function for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0015194 L-serine transmembrane transporter activity ISS,IBA --
genes like me logo Genes that share ontologies with SERINC1: view
genes like me logo Genes that share phenotypes with SERINC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC1

miRNA for SERINC1 Gene

miRTarBase miRNAs that target SERINC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERINC1 Gene

Localization for SERINC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SERINC1 Gene COMPARTMENTS Subcellular localization image for SERINC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERINC1: view

Pathways & Interactions for SERINC1 Gene

genes like me logo Genes that share pathways with SERINC1: view

Pathways by source for SERINC1 Gene

Gene Ontology (GO) - Biological Process for SERINC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006658 phosphatidylserine metabolic process ISS --
GO:0006665 sphingolipid metabolic process ISS --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0015825 L-serine transport ISS --
genes like me logo Genes that share ontologies with SERINC1: view

No data available for SIGNOR curated interactions for SERINC1 Gene

Drugs & Compounds for SERINC1 Gene

(1) Drugs for SERINC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist Weak endogenous glycine receptor agonist 0

(124) Additional Compounds for SERINC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with SERINC1: view

Transcripts for SERINC1 Gene

mRNA/cDNA for SERINC1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(632) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SERINC1 Gene

Serine incorporator 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - - - - - - - - - - - -
SP13: -

ExUns: 11a · 11b · 11c · 11d · 11e · 11f

Relevant External Links for SERINC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERINC1 Gene

mRNA expression in normal human tissues for SERINC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC1 Gene

This gene is overexpressed in Adrenal (51.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERINC1 Gene

Protein tissue co-expression partners for SERINC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERINC1 Gene:


SOURCE GeneReport for Unigene cluster for SERINC1 Gene:

genes like me logo Genes that share expression patterns with SERINC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERINC1 Gene

Orthologs for SERINC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERINC1 34 35
  • 99.71 (n)
(Bos Taurus)
Mammalia SERINC1 34 35
  • 93.3 (n)
-- 35
  • 91 (a)
(Canis familiaris)
Mammalia SERINC1 34 35
  • 93.01 (n)
(Mus musculus)
Mammalia Serinc1 34 16 35
  • 89.92 (n)
(Rattus norvegicus)
Mammalia Serinc1 34
  • 89.92 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
-- 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SERINC1 35
  • 84 (a)
(Gallus gallus)
Aves SERINC1 34 35
  • 79.65 (n)
(Anolis carolinensis)
Reptilia SERINC1 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc1 34
  • 77.9 (n)
Str.2375 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9926 34
(Danio rerio)
Actinopterygii serinc1 34 35
  • 72.52 (n)
wufd02g01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4299 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002569 34
  • 53.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta TMS1 34 35
  • 50.75 (n)
(Caenorhabditis elegans)
Secernentea CELE_R11H6.2 34
  • 52.35 (n)
R11H6.2 35
  • 43 (a)
Y57E12AL.1 35
  • 43 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11935g 34
  • 46.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 34 35
  • 45.97 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR100W 34
  • 45.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06170 34
  • 44.36 (n)
(Oryza sativa)
Liliopsida Os03g0454100 34
  • 44.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
-- 35
  • 53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB1A10.07c 34
  • 46.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07986 34
  • 45.49 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4846 34
Species where no ortholog for SERINC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC1 Gene

Gene Tree for SERINC1 (if available)
Gene Tree for SERINC1 (if available)

Paralogs for SERINC1 Gene

Paralogs for SERINC1 Gene

(4) SIMAP similar genes for SERINC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SERINC1: view

Variants for SERINC1 Gene

Sequence variations from dbSNP and Humsavar for SERINC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456947 -- 122,471,944(+) ACGAC(A/G)CGGCT upstream-variant-2KB, utr-variant-5-prime
rs10457433 -- 122,449,634(+) tctcc(A/G)taaca intron-variant
rs10484445 -- 122,448,707(-) TAGAG(C/T)ATATA intron-variant
rs1053459 -- 122,451,725(-) TTACA(A/G)TCTTC reference, synonymous-codon
rs10535596 -- 122,472,454(+) CAAAC(-/AT)TGATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERINC1 Gene

Variant ID Type Subtype PubMed ID
esv2759467 CNV loss 17122850
nsv1018215 CNV loss 25217958
nsv1161448 CNV duplication 26073780

Variation tolerance for SERINC1 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERINC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC1 Gene

Disorders for SERINC1 Gene

Relevant External Links for SERINC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERINC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERINC1 Gene

Publications for SERINC1 Gene

  1. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for SERINC1 Gene

Sources for SERINC1 Gene

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