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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERHL2 Gene

protein-coding GIFtS: 48
GCID: GC22P042949

serine hydrolase-like 2

Explore 1 disease affiliated with
SERHL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serine Hydrolase-Like 2¹ ²
DJ222E13.1¹
Serine Hydrolase-Like Protein 2²
EC 3.1.-.-³
SERHL³

External Ids:	HGNC: 29446¹	Entrez Gene: 253190²	Ensembl: ENSG00000183569⁷	UniProtKB: Q9H4I8³

Export aliases for SERHL2 gene to outside databases

Previous GC identifers: GC22P041275 GC22P025910

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8

Function: Probable serine hydrolase. May be related to cell muscle hypertrophy

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERHL2 gene promoter:
FOXF2 MyoD RelA POU3F2 NF-kappaB PPAR-gamma1 COMP1 PPAR-gamma2 NF-kappaB1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERHL2 promoter sequence

Search SABiosciences Chromatin IP Primers for SERHL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERHL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13

SERHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERHL2 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P042949: view genomic region (about GC identifiers)

Start:	42,949,623 bp from pter	End:	42,970,388 bp from pter
Size:	20,766 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8 (See protein sequence)

Recommended Name: Serine hydrolase-like protein 2

Size: 314 amino acids; 35369 Da

Subcellular location: Cytoplasm, perinuclear region (By similarity). Peroxisome (By similarity). Note=Concentrated in

perinuclear vesicles (By similarity). May be located in peroxisomes (By similarity)

Miscellaneous: This gene may have been partially duplicated (see SERHL)

Secondary accessions: B1AHE9 B1AHF0 Q0VDJ1 Q5H973 Q9BR29 Q9BR30 Q9Y3I9

Alternative splicing: 3 isoforms: Q9H4I8-1 Q9H4I8-2 Q9H4I8-3

Explore the universe of human proteins at neXtProt for SERHL2: NX_Q9H4I8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H4I8

SERHL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055324.2

ENSEMBL proteins:

ENSP00000395860 ENSP00000435091 ENSP00000413512 ENSP00000331376 ENSP00000385691

ENSP00000336578 ENSP00000342425

Human Recombinant Protein Products for SERHL2:

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	Uscn Proteins for SERHL2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005739	mitochondrion	IEA	--
GO:0005777	peroxisome	IEA	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

SERHL2 for ontologies About GeneDecksing

SERHL2 Antibody Products:

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	Novus Biologicals SERHL2 Antibody
	Abcam antibodies for SERHL2
	Uscn Antibodies for SERHL2
	ThermoFisher Antibody for SERHL2

Assay Products for SERHL2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for SERHL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERHL2 for domains About GeneDecksing

1 InterPro domain/family:

IPR000073 AB_hydrolase_1

Graphical View of Domain Structure for InterPro Entry Q9H4I8

ProtoNet protein and cluster: Q9H4I8

1 Blocks protein family: IPB000073 Alpha/beta hydrolase fold

UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8

Similarity: Belongs to the AB hydrolase superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEHL2_HUMAN, Q9H4I8

Function: Probable serine hydrolase. May be related to cell muscle hypertrophy

Enzyme Number (IUBMB): EC 3.1.-.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0016787	hydrolase activity	IEA	--

SERHL2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SERHL2

miRNA Products:		miRTarBase miRNAs that target SERHL2: hsa-mir-346 (MIRT004221)

		OriGene 3'-UTR Clone: SERHL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERHL2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERHL2
		SwitchGear 3'UTR luciferase reporter plasmid: SERHL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SERHL2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERHL2 (NM_014509)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERHL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SERHL2
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		Sirion Biotech Customized stable knockdown cell line services for SERHL2 Sirion Biotech Customized inducible knockdown cell line services for SERHL2 Sirion Biotech Customized stable overexpressing cell line services for SERHL2 Sirion Biotech Customized inducible overexpressing cell line services for SERHL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SERHL2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SERHL2 (ENSP00000331376⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

SERHL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERHL2
Search CenterWatch for drugs/clinical trials and news about SERHL2 / SEHL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SERHL2 gene:

NM_014509.3

Unigene Cluster for SERHL2:

Serine hydrolase-like 2

Hs.728878 [show with all ESTs]

Unigene Representative Sequence: AK294584

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000447870 ENST00000477564(uc010gyy.3 uc011apo.2) ENST00000534080

ENST00000416156(uc011apn.1) ENST00000327678(uc003bcr.3 uc010gyz.3)

ENST00000527167 ENST00000407614 ENST00000335879 ENST00000472589 ENST00000340239

miRNA Products:		OriGene 3'-UTR Clone: SERHL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SERHL2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SERHL2
		SwitchGear 3'UTR luciferase reporter plasmid: SERHL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERHL2 (see all 4) OriGene shRNA RFP: SERHL2 OriGene siRNA: SERHL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERHL2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SERHL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SERHL2 (NM_014509)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERHL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERHL2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERHL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERHL2

Additional cDNA sequence:

AK294584.1 AK295223.1 AL450314.1 AL589866.1 AL590118.1 AL590120.1 BC119650.2 BC119651.1

BC127635.1 BC127636.1 CR456455.1

11 DOTS entries:

DT.451575 DT.92449660 DT.97854916 DT.100834192 DT.208196 DT.120649679 DT.100648969 DT.209210

DT.102843074 DT.97854914 DT.99949605

24/103 AceView cDNA sequences (see all 103):

NM_014509 BM704551 AA975753 BM473055 AL450314 BM992883 AL590120 NM_170694

AK094872 CR626440 CD723288 AL365513 BM505049 BM824445 AL590118 BU684615

H55243 CD367673 BX446208 BF508719 BX480309 BU616443 AI633848 CD625752

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERHL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCCAGCCC

About this image

SERHL2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SERHL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERHL2

SOURCE GeneReport for Unigene cluster: Hs.728878

SABiosciences Custom PCR Arrays for SERHL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERHL2 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat SERHL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERHL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERHL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SERHL2 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Serhl^{1 , 5}	serine hydrolase-like^{1, 5}	77.18(n)¹ 68.46(a)¹		15 (39.32 cM)⁵ 68607¹ NM_023475.3¹ NP_075964.1¹ 83089506⁵
chicken (Gallus gallus)	Aves	SERHL2¹	serine hydrolase-like 2	60.43(n) 51.7(a)		417976 XM_416214.2 XP_416214.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	50(a) 44(a)	many → 1 many → 1	GL343614.1(155168-169686) GL343614.1(175115-189451)
African clawed frog (Xenopus laevis)	Amphibia	BC045088.1²	--	72.05(n)		BC045088.1
zebrafish (Danio rerio)	Actinopterygii	serhl¹	serine hydrolase-like	51.71(n) 42.05(a)		322648 NM_199615.1 NP_955909.1
fruit fly (Drosophila melanogaster)	Insecta	kraken¹	CG3943-PA	47.94(n) 34.98(a)		33265 NM_057917.3 NP_477265.1

ENSEMBL Gene Tree for SERHL2 (if available)
TreeFam Gene Tree for SERHL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SERHL2 gene

2 SIMAP similar genes for SERHL2 using alignment to 6 protein entries: SEHL2_HUMAN (see all proteins):

SERHL dJ222E13.1

SERHL2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SERHL2
PGOHUM00000250343 PGOHUM00000250344

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73888333^1,2	C	--	42948028(+)	`TGGGCG/AATCAG`	1	--	us2k¹		1		WA	2
rs3939039^1,2	C	--	42948172(+)	`CTTGGC/TAACGG`	1	--	us2k¹		0	--	--	--	--
rs112147198^1,2	C	--	42948179(+)	`ACGGGC/TGTCTT`	1	--	us2k¹		0	--	--	--	--
rs136991^1,2	C,F	--	42948236(+)	`CTGTCC/TGGGCA`	1	--	us2k¹		4		MN NA CSA	190
rs180995262^1,2		--	42948255(+)	`GGCTCG/TCACTC`	1	--	us2k¹		0	--	--	--	--
rs185823353^1,2		--	42948280(+)	`CTTCTC/TGCTAT`	1	--	us2k¹		0	--	--	--	--
rs190932097^1,2		--	42948281(+)	`TTCTCC/GCTATG`	1	--	us2k¹		0	--	--	--	--
rs142668406^1,2		--	42948444(+)	`AACTAC/TTCTTA`	1	--	us2k¹		0	--	--	--	--
rs183075992^1,2		--	42948555(+)	`GAAAAA/CTTTGA`	1	--	us2k¹		0	--	--	--	--
rs186246638^1,2		--	42948601(+)	`TATAAC/GAAATC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERHL2 (42949623 - 42970388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for SERHL2
9 CNVs: 3242 32470 79589 7351 31094 79584 4129 67897 32471

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERHL2

DNA2.0 Custom Variant and Variant Library Synthesis for SERHL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERHL2 for disorders About GeneDecksing

1 disease for SERHL2: About MalaCards

muscle hypertrophy

Human Genome Epidemiology (HuGE) Navigator: SERHL2 (1 document)

Export disorders for SERHL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERHL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERHL2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)^{1, 2} Collins J.E.... Dunham I. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)¹ Collins J.E.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)
Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. (PubMed id 11352564)¹ Sadusky T.J....Coulton G.R. (2001)
Early gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetry. (PubMed id 18464067)⁹ Turtoi A....Schneeweiss F.H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 253190	HGNC: 29446	AceView: dJ222E13.1andSERHL	Ensembl:ENSG00000183569	euGenes: HUgn253190
ECgene: SERHL2	H-InvDB: SERHL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERHL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERHL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SERHL2 gene:
Search GeneIP for patents involving SERHL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SERHL2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERHL2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERHL2
	OriGene Protein Over-expression Lysate for SERHL2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SERHL2		OriGene 3'-UTR Clone for SERHL2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERHL2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SERHL2		OriGene Custom Protein Services for SERHL2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERHL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERHL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERHL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERHL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERHL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERHL2

	GenScript Custom Purified and Recombinant Proteins Services for SERHL2		GenScript cDNA clones with any tag delivered in your preferred vector for SERHL2
	GenScript Custom Assay Services for SERHL2		GenScript Custom Superior Antibodies Services for SERHL2
	GenScript Custom overexpressing Cell Line Services for SERHL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in SERHL2 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for SERHL2
	See all of Abcam's Antibodies, Kits and Proteins for SERHL2
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Browse ProSpec Recombinant Proteins

SERHL2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SERHL2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL2

	SwitchGear 3'UTR luciferase reporter plasmids for SERHL2
	SwitchGear Promoter luciferase reporter plasmids for SERHL2

ThermoFisher Antibody for SERHL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SERHL2

Sirion Biotech Customized:

	stable knockdown cell line services for SERHL2
	inducible knockdown cell line services for SERHL2
	design and validation of potent shRNA sequences against SERHL2
	adenovirus for potent knockdown of SERHL2
	adenovirus for overexpression of SERHL2
	stable overexpressing cell line services for SERHL2
	inducible overexpressing cell line services for SERHL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SERHL2 gene at Home site.

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SERHL2 Gene

serine hydrolase-like 2

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SERHL2 Gene

serine hydrolase-like 2

Aliasesfor SERHL2 gene

Summariesfor SERHL2 gene

Genomic Viewsfor SERHL2 gene

Proteinsfor SERHL2 gene

Protein Domains /Familiesfor SERHL2 gene

Functionfor SERHL2 gene

Pathways & Interactionsfor SERHL2 gene

Drugs & Compoundsfor SERHL2 gene

Transcriptsfor SERHL2 gene

Expression for SERHL2 gene

Orthologsfor SERHL2 gene

Paralogsfor SERHL2 gene

Genomic Variantsfor SERHL2 gene

Disorders / Diseasesfor SERHL2 gene

Publicationsfor SERHL2 gene

External Searches for SERHL2 gene

Genome Databases showing SERHL2 gene

Other Databases showing SERHL2 gene

Specialized Databases showing SERHL2 gene

Intellectual Propertyfor SERHL2 gene

Productsfor SERHL2 gene

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Aliases
for SERHL2 gene

Summaries
for SERHL2 gene

Genomic Views
for SERHL2 gene

Proteins
for SERHL2 gene

Protein Domains /
Families
for SERHL2 gene

Function
for SERHL2 gene

Pathways & Interactions
for SERHL2 gene

Drugs & Compounds
for SERHL2 gene

Transcripts
for SERHL2 gene

Expression
for SERHL2 gene

Orthologs
for SERHL2 gene

Paralogs
for SERHL2 gene

Genomic Variants
for SERHL2 gene

Disorders / Diseases
for SERHL2 gene

Publications
for SERHL2 gene

Intellectual Property
for SERHL2 gene

Products
for SERHL2 gene