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SERHL2 Gene

protein-coding   GIFtS: 46
GCID: GC22P042949

Serine Hydrolase-Like 2

  Search for SERHL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Hydrolase-Like 21 2
dJ222E13.12
Serine Hydrolase-Like Protein 22
EC 3.1.-.-3
SERHL3

External Ids:    HGNC: 294461   Entrez Gene: 2531902   Ensembl: ENSG000001835697   UniProtKB: Q9H4I83   

Export aliases for SERHL2 gene to outside databases

Previous GC identifers: GC22P041275 GC22P025910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERHL2 Gene:
SERHL2 (serine hydrolase-like 2) is a protein-coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8
Function: Probable serine hydrolase. May be related to cell muscle hypertrophy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SERHL2 gene promoter:
         FOXF2   MyoD   RelA   POU3F2   NF-kappaB   PPAR-gamma1   COMP1   PPAR-gamma2   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERHL2 promoter sequence
   Search Chromatin IP Primers for SERHL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERHL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

SERHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERHL2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P042949:  view genomic region     (about GC identifiers)

Start:
42,949,623 bp from pter      End:
42,970,388 bp from pter
Size:
20,766 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8 (See protein sequence)
Recommended Name: Serine hydrolase-like protein 2  
Size: 314 amino acids; 35369 Da
Miscellaneous: This gene may have been partially duplicated (see SERHL)
Secondary accessions: B1AHE9 B1AHF0 Q0VDJ1 Q5H973 Q9BR29 Q9BR30 Q9Y3I9
Alternative splicing: 3 isoforms:  Q9H4I8-1   Q9H4I8-2   Q9H4I8-3   

Explore the universe of human proteins at neXtProt for SERHL2: NX_Q9H4I8

Explore proteomics data for SERHL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERHL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001271263.1  NP_055324.2  

    ENSEMBL proteins: 
     ENSP00000395860   ENSP00000435091   ENSP00000413512   ENSP00000331376   ENSP00000385691  
     ENSP00000336578   ENSP00000342425  

    SERHL2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SERHL2

     
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    SERHL2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SERHL2
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    Search eBioscience for ELISAs for SERHL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000073 AB_hydrolase_1

    Graphical View of Domain Structure for InterPro Entry Q9H4I8

    ProtoNet protein and cluster: Q9H4I8

    1 Blocks protein domain: IPB000073 Alpha/beta hydrolase fold

    UniProtKB/Swiss-Prot: SEHL2_HUMAN, Q9H4I8
    Similarity: Belongs to the AB hydrolase superfamily


    Find genes that share domains with SERHL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEHL2_HUMAN, Q9H4I8
    Function: Probable serine hydrolase. May be related to cell muscle hypertrophy

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with SERHL2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERHL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERHL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERHL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERHL2

    miRNA
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    miRTarBase miRNAs that target SERHL2:
    hsa-mir-346 (MIRT004221)

    Block miRNA regulation of human, mouse, rat SERHL2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SERHL2
    SwitchGear 3'UTR luciferase reporter plasmidSERHL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERHL2
    Predesigned siRNA for gene silencing in human, mouse, rat SERHL2

    Gene Editing
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    Sino Biological Human cDNA Clone for SERHL2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEHL2_HUMAN, Q9H4I8: Cytoplasm, perinuclear region (By similarity). Peroxisome (By similarity). Note=Concentrated
    in perinuclear vesicles (By similarity). May be located in peroxisomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with SERHL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERHL2
    Interactions:

        Search GeneGlobe Interaction Network for SERHL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SERHL2 (ENSP000003313764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with SERHL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERHL2 (SEHL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERHL2 gene (2 alternative transcripts): 
    NM_001284334.1  NM_014509.4  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447870 ENST00000477564(uc010gyy.3 uc011apo.2) ENST00000534080
    ENST00000416156(uc011apn.1) ENST00000327678(uc003bcr.3 uc010gyz.3)
    ENST00000527167 ENST00000407614 ENST00000335879 ENST00000472589 ENST00000340239

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SERHL2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SERHL2
    SwitchGear 3'UTR luciferase reporter plasmidSERHL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SERHL2
    Predesigned siRNA for gene silencing in human, mouse, rat SERHL2
    Clone
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    OriGene clones in human, mouse for SERHL2 (see all 7)
    OriGene ORF clones in mouse, rat for SERHL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERHL2 (NM_014509)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERHL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SERHL2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SERHL2
      QuantiTect SYBR Green Assays in human, mouse, rat SERHL2
      QuantiFast Probe-based Assays in human, mouse, rat SERHL2

    Selected AceView cDNA sequences (see all 103):

    NM_014509 NM_170694 AA975753 BM824445 CD367673 AL590118 BM992883 AK094872 
    AL450314 BM473055 AL365513 CD723288 BU684615 H55243 BM505049 AL590120 
    BM704551 CR626440 BC041802 AA652524 BV188109 Z40556 BM930864 BI918881 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERHL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCAGCCC
    SERHL2 Expression
    About this image


    SERHL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Breast (Uncategorized)
    SERHL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERHL2 Protein Expression
        Custom PCR Arrays for SERHL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SERHL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serhl1 , 5 serine hydrolase-like1, 5 77.18(n)1
    68.46(a)1
      15 (39.32 cM)5
    686071  NM_023475.31  NP_075964.11 
     830895065 
    chicken
    (Gallus gallus)
    Aves SERHL21 serine hydrolase-like 2 59.84(n)
    51.01(a)
      417976  NM_001277373.1  NP_001264302.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERHL26
    serine hydrolase-like 2
    44(a)
    1 ↔ 1
    GL343614.1(150633-189451)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045088.12   -- 72.05(n)    BC045088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii serhl1 serine hydrolase-like 51.17(n)
    41.61(a)
      322648  NM_199615.1  NP_955909.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kraken1 kraken 47.87(n)
    35.46(a)
      33265  NM_057917.4  NP_477265.1 


    ENSEMBL Gene Tree for SERHL2 (if available)
    TreeFam Gene Tree for SERHL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERHL2 gene
    2 SIMAP similar genes for SERHL2 using alignment to 6 protein entries:     SEHL2_HUMAN (see all proteins):
    SERHL    dJ222E13.1

    Find genes that share paralogs with SERHL2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SERHL2
    PGOHUM00000250343 PGOHUM00000250344


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERHL2 (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1370041,2
    C,F--26870664(+) GTCCTC/GCATTC 1 -- int14Minor allele frequency- G:0.30EA NA 1476
    rs738883331,2
    C--42948028(+) TGGGCG/AATCAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs39390391,2
    C--42948172(+) CTTGGC/TAACGG 1 -- us2k10--------
    rs1121471981,2
    C--42948179(+) ACGGGC/TGTCTT 1 -- us2k10--------
    rs1369911,2
    C,F--42948236(+) ctgtcC/Tgggca 1 -- us2k14Minor allele frequency- T:0.19MN NA CSA 190
    rs1809952621,2
    --42948255(+) GGCTCG/TCACTC 1 -- us2k10--------
    rs1858233531,2
    --42948280(+) CTTCTC/TGCTAT 1 -- us2k10--------
    rs1909320971,2
    --42948281(+) TTCTCC/GCTATG 1 -- us2k10--------
    rs1426684061,2
    --42948444(+) AACTAC/TTCTTA 1 -- us2k10--------
    rs1830759921,2
    --42948555(+) GAAAAA/CTTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SERHL2 (42949623 - 42970388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SERHL2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659886CNV Deletion23128226
    esv2658455CNV Deletion23128226
    dgv781e201CNV Deletion23290073
    nsv436074CNV Insertion17901297
    nsv829246CNV Loss20364138
    nsv511642CNV Loss21212237
    esv28197CNV Gain19812545
    dgv103e180CNV Gain20482838
    esv32632CNV Gain17666407
    nsv915179CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SERHL2           About GenesLikeMe

    Genetic Association Database (GAD): SERHL2
    Human Genome Epidemiology (HuGE) Navigator: SERHL2 (1 document)

    Export disorders for SERHL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERHL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SERHL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
    9. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. (PubMed id 11352564)1 Sadusky T.J....Coulton G.R. (Genomics 2001)
    10. Early gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetry. (PubMed id 18464067)9 Turtoi A....Schneeweiss F.H. (Int. J. Radiat. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253190 HGNC: 29446 AceView: dJ222E13.1andSERHL Ensembl:ENSG00000183569 euGenes: HUgn253190
    ECgene: SERHL2 H-InvDB: SERHL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERHL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERHL2 gene:
    Search GeneIP for patents involving SERHL2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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