Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERHL2 Gene

Aliases for SERHL2 Gene

  • Serine Hydrolase-Like 2 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 216e 3
  • Serine Hydrolase-Like Protein 2 3
  • DJ222E13.1 3
  • EC 3.1.-.- 4
  • SERHL 4

External Ids for SERHL2 Gene

Previous GeneCards Identifiers for SERHL2 Gene

  • GC22P041275
  • GC22P042949
  • GC22P025910
  • GC22P042553

Summaries for SERHL2 Gene

GeneCards Summary for SERHL2 Gene

SERHL2 (Serine Hydrolase-Like 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for SERHL2 Gene

  • Probable serine hydrolase. May be related to cell muscle hypertrophy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERHL2 Gene

Genomics for SERHL2 Gene

Regulatory Elements for SERHL2 Gene

Enhancers for SERHL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F042612 1.2 ENCODE 16.3 +95.8 95750 4.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 XRCC6 RPL5P34 FAM109B RRP7BP CYB5R3 SERHL2 ATP5L2 NAGA GC22P042614 PIR37149
GH22F042681 1.6 FANTOM5 Ensembl ENCODE 9.3 +167.3 167304 8.9 ATF1 PKNOX1 ARID4B DMAP1 YY1 ZNF121 ZNF263 JUNB KAT8 NFIL3 A4GALT CYB5R3 POLDIP3 SERHL2 TSPO MCAT GC22M042668
GH22F042641 1.1 ENCODE 11.2 +127.0 126968 9.3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RPS25P10 HMGN2P10 SERHL2 CYB5R3 A4GALT RRP7BP GC22P042648 ATP5L2
GH22F042617 0.6 ENCODE 18.6 +99.1 99126 0.6 PAF1 RFX1 MXD4 SSRP1 POLR2A ZNF366 ZNF692 TCF7 PRDM1 SERHL2 A4GALT ENSG00000270022 RNU12 ATP5L2
GH22F042561 1 Ensembl ENCODE 11.1 +43.5 43505 1.9 ESRRA RARA GLIS2 GATA2 POLR2A PRDM10 NR2F6 GATAD2A TEAD1 NR2F1 RRP7BP SERHL2 CYB5R3 GC22M042566 RN7SKP80 GC22M042540
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERHL2 on UCSC Golden Path with GeneCards custom track

Promoters for SERHL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000618982 865 1201 HDGF ELF3 TBP PKNOX1 ZNF76 KLF17 ARID4B SIN3A DMAP1 ZNF48

Genomic Location for SERHL2 Gene

42,518,735 bp from pter
42,574,382 bp from pter
55,648 bases
Plus strand

Genomic View for SERHL2 Gene

Genes around SERHL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERHL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERHL2 Gene

Proteins for SERHL2 Gene

  • Protein details for SERHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine hydrolase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B1AHE9
    • B1AHF0
    • Q0VDJ1
    • Q5H973
    • Q9BR29
    • Q9BR30
    • Q9Y3I9

    Protein attributes for SERHL2 Gene

    314 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available
    • This gene may have been partially duplicated (see SERHL).

    Alternative splice isoforms for SERHL2 Gene


neXtProt entry for SERHL2 Gene

Post-translational modifications for SERHL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SERHL2 Gene

Domains & Families for SERHL2 Gene

Protein Domains for SERHL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the AB hydrolase superfamily.
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with SERHL2: view

No data available for Gene Families for SERHL2 Gene

Function for SERHL2 Gene

Molecular function for SERHL2 Gene

UniProtKB/Swiss-Prot Function:
Probable serine hydrolase. May be related to cell muscle hypertrophy.

Enzyme Numbers (IUBMB) for SERHL2 Gene

Gene Ontology (GO) - Molecular Function for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA,IBA --
genes like me logo Genes that share ontologies with SERHL2: view
genes like me logo Genes that share phenotypes with SERHL2: view

Animal Model Products

miRNA for SERHL2 Gene

miRTarBase miRNAs that target SERHL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERHL2 Gene

Localization for SERHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERHL2 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERHL2 gene
Compartment Confidence
peroxisome 5
nucleus 4
mitochondrion 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA --
GO:0005777 peroxisome IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SERHL2: view

Pathways & Interactions for SERHL2 Gene

SuperPathways for SERHL2 Gene

No Data Available

Interacting Proteins for SERHL2 Gene

Gene Ontology (GO) - Biological Process for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SERHL2: view

No data available for Pathways by source and SIGNOR curated interactions for SERHL2 Gene

Transcripts for SERHL2 Gene

Unigene Clusters for SERHL2 Gene

Serine hydrolase-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERHL2 Gene

No ASD Table

Relevant External Links for SERHL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERHL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERHL2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERHL2 Gene

Protein tissue co-expression partners for SERHL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERHL2 Gene:


SOURCE GeneReport for Unigene cluster for SERHL2 Gene:

genes like me logo Genes that share expression patterns with SERHL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERHL2 Gene

Orthologs for SERHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERHL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC746330 34
  • 96 (n)
  • 93 (a)
(Bos Taurus)
Mammalia SERHL2 34 35
  • 79.48 (n)
(Canis familiaris)
Mammalia SERHL2 34 35
  • 78.62 (n)
(Mus musculus)
Mammalia Serhl 34 16 35
  • 77.18 (n)
(Rattus norvegicus)
Mammalia Serhl2 34
  • 76.62 (n)
(Ornithorhynchus anatinus)
Mammalia SERHL2 35
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
-- 35
  • 45 (a)
(Gallus gallus)
Aves SERHL2 34 35
  • 59.84 (n)
(Anolis carolinensis)
Reptilia SERHL2 35
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serhl2 34
  • 52.82 (n)
(Danio rerio)
Actinopterygii serhl 34 35
  • 51.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta kraken 34 35
  • 47.87 (n)
CG15820 35
  • 31 (a)
CG7632 35
  • 28 (a)
CG15879 35
  • 25 (a)
CG5704 35
  • 25 (a)
CG11309 35
  • 23 (a)
CG5707 35
  • 20 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010246 34
  • 43.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
CSA.838 35
  • 27 (a)
Species where no ortholog for SERHL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERHL2 Gene

Gene Tree for SERHL2 (if available)
Gene Tree for SERHL2 (if available)

Paralogs for SERHL2 Gene

(2) SIMAP similar genes for SERHL2 Gene using alignment to 6 proteins: Pseudogenes for SERHL2 Gene

genes like me logo Genes that share paralogs with SERHL2: view

No data available for Paralogs for SERHL2 Gene

Variants for SERHL2 Gene

Sequence variations from dbSNP and Humsavar for SERHL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1046408 -- 42,570,837(-) CTGTG(A/T)GATTA intron-variant
rs1046409 -- 42,570,828(-) TAAAG(G/T)CAGAG intron-variant
rs1046410 -- 42,570,804(-) CACTT(C/T)TGGGC intron-variant
rs1046413 -- 42,570,693(-) AGGAG(A/G)AAGAA intron-variant
rs1046418 -- 42,570,582(-) ATGGC(A/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERHL2 Gene

Variant ID Type Subtype PubMed ID
nsv9912 CNV gain+loss 18304495
nsv829246 CNV loss 20364138
nsv589083 CNV loss 21841781
nsv589078 CNV gain 21841781
nsv511642 CNV loss 21212237
nsv436074 CNV insertion 17901297
nsv428391 CNV gain 18775914
nsv1160776 CNV duplication 26073780
nsv1160775 CNV deletion 26073780
nsv1062078 CNV loss 25217958
nsv1057729 CNV loss 25217958
esv3647835 CNV loss 21293372
esv3647834 CNV loss 21293372
esv3575492 CNV gain 25503493
esv3575487 CNV gain 25503493
esv3568423 CNV loss 25503493
esv3568421 CNV loss 25503493
esv3568419 CNV loss 25503493
esv32632 CNV gain 17666407
esv2967124 CNV duplication 24192839
esv28197 CNV gain 19812545
esv2758839 CNV gain+loss 17122850
esv2659886 CNV deletion 23128226
esv2658455 CNV deletion 23128226
dgv843e214 CNV gain 21293372
dgv8119n54 CNV gain 21841781
dgv8118n54 CNV loss 21841781
dgv8117n54 CNV gain 21841781
dgv773n67 CNV gain 20364138
dgv734e201 CNV deletion 23290073
dgv4585n100 CNV gain 25217958
dgv4584n100 CNV gain 25217958
dgv4583n100 CNV gain+loss 25217958
dgv4579n100 CNV gain+loss 25217958
dgv4578n100 CNV gain 25217958
dgv4577n100 CNV gain 25217958
dgv175n111 CNV duplication 26073780
dgv173n111 CNV duplication 26073780
dgv1323e212 CNV loss 25503493
dgv1322e212 CNV gain 25503493
dgv1321e212 CNV gain 25503493
dgv103e180 CNV gain 20482838
dgv101e203 CNV gain+loss 21179565

Variation tolerance for SERHL2 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 62.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERHL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERHL2 Gene

Disorders for SERHL2 Gene

Relevant External Links for SERHL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERHL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERHL2 Gene

Publications for SERHL2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 64
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  5. Early gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetry. (PMID: 18464067) Turtoi A. … Schneeweiss F.H. (Int. J. Radiat. Biol. 2008) 22 64

Products for SERHL2 Gene

Sources for SERHL2 Gene

Loading form....