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Aliases for SERHL2 Gene

Aliases for SERHL2 Gene

  • Serine Hydrolase-Like 2 2 3
  • Serine Hydrolase-Like Protein 2 3
  • DJ222E13.1 3
  • EC 3.1.-.- 4
  • SERHL 4

External Ids for SERHL2 Gene

Previous GeneCards Identifiers for SERHL2 Gene

  • GC22P041275
  • GC22P042949
  • GC22P025910

Summaries for SERHL2 Gene

GeneCards Summary for SERHL2 Gene

SERHL2 (Serine Hydrolase-Like 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for SERHL2 Gene

  • Probable serine hydrolase. May be related to cell muscle hypertrophy

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERHL2 Gene

Genomics for SERHL2 Gene

Regulatory Elements for SERHL2 Gene

Genomic Location for SERHL2 Gene

42,553,617 bp from pter
42,574,382 bp from pter
20,766 bases
Plus strand

Genomic View for SERHL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERHL2 Gene

Proteins for SERHL2 Gene

  • Protein details for SERHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine hydrolase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B1AHE9
    • B1AHF0
    • Q0VDJ1
    • Q5H973
    • Q9BR29
    • Q9BR30
    • Q9Y3I9

    Protein attributes for SERHL2 Gene

    314 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available
    • This gene may have been partially duplicated (see SERHL)

    Alternative splice isoforms for SERHL2 Gene


neXtProt entry for SERHL2 Gene

Proteomics data for SERHL2 Gene at MOPED

Post-translational modifications for SERHL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SERHL2 Gene

Domains for SERHL2 Gene

Protein Domains for SERHL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H4I8
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with SERHL2: view

No data available for Gene Families for SERHL2 Gene

Function for SERHL2 Gene

Molecular function for SERHL2 Gene

UniProtKB/Swiss-Prot Function: Probable serine hydrolase. May be related to cell muscle hypertrophy

Enzyme Numbers (IUBMB) for SERHL2 Gene

Gene Ontology (GO) - Molecular Function for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SERHL2: view

miRNA for SERHL2 Gene

miRTarBase miRNAs that target SERHL2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERHL2 Gene

Localization for SERHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERHL2 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Concentrated in perinuclear vesicles. May be located in peroxisomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SERHL2 Gene COMPARTMENTS Subcellular localization image for SERHL2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SERHL2: view

Pathways for SERHL2 Gene

SuperPathways for SERHL2 Gene

No Data Available

Interacting Proteins for SERHL2 Gene

Gene Ontology (GO) - Biological Process for SERHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SERHL2: view

No data available for Pathways by source for SERHL2 Gene

Transcripts for SERHL2 Gene

Unigene Clusters for SERHL2 Gene

Serine hydrolase-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERHL2 Gene

No ASD Table

Relevant External Links for SERHL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERHL2 Gene

mRNA expression in normal human tissues for SERHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERHL2 Gene

SOURCE GeneReport for Unigene cluster for SERHL2 Gene Hs.728878

genes like me logo Genes that share expressions with SERHL2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERHL2 Gene

Orthologs for SERHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERHL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC746330 35
  • 96 (n)
  • 92.93 (a)
  • 93 (a)
(Bos Taurus)
Mammalia SERHL2 35
  • 79.48 (n)
  • 70.36 (a)
  • 70 (a)
(Canis familiaris)
Mammalia SERHL2 35
  • 78.62 (n)
  • 67.43 (a)
  • 67 (a)
(Mus musculus)
Mammalia Serhl 35
  • 77.18 (n)
  • 68.46 (a)
Serhl 16
Serhl 36
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
-- 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia SERHL2 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Serhl2 35
  • 76.62 (n)
  • 67.11 (a)
(Gallus gallus)
Aves SERHL2 35
  • 59.84 (n)
  • 51.01 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia SERHL2 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia serhl2 35
  • 52.82 (n)
  • 45.18 (a)
(Danio rerio)
Actinopterygii serhl 35
  • 51.17 (n)
  • 41.61 (a)
serhl 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010246 35
  • 43.26 (n)
  • 35.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11309 36
  • 23 (a)
CG15820 36
  • 31 (a)
CG15879 36
  • 25 (a)
CG5704 36
  • 25 (a)
CG5707 36
  • 20 (a)
CG7632 36
  • 28 (a)
kraken 35
  • 47.87 (n)
  • 35.46 (a)
kraken 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
CSA.838 36
  • 27 (a)
Species with no ortholog for SERHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERHL2 Gene

Gene Tree for SERHL2 (if available)
Gene Tree for SERHL2 (if available)

Paralogs for SERHL2 Gene

Selected SIMAP similar genes for SERHL2 Gene using alignment to 6 proteins: Pseudogenes for SERHL2 Gene

genes like me logo Genes that share paralogs with SERHL2: view

No data available for Paralogs for SERHL2 Gene

Variants for SERHL2 Gene

Sequence variations from dbSNP and Humsavar for SERHL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs136991 -- 42,552,230(+) ctgtc(C/T)gggca upstream-variant-2KB
rs136992 -- 42,552,879(+) tgggc(G/T)acaaa upstream-variant-2KB
rs136993 -- 42,553,637(+) CTCCC(-/C)GGGTC upstream-variant-2KB
rs137015 -- 42,559,379(+) ccagt(C/T)tgggt intron-variant
rs137016 -- 42,559,389(+) tgaca(-/AA)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERHL2 Gene

Variant ID Type Subtype PubMed ID
dgv1407e1 CNV Complex 17122850
nsv428391 CNV Gain 18775914
essv4940 CNV CNV 17122850
esv32632 CNV Gain 17666407
esv28197 CNV Gain 19812545
nsv9912 CNV Gain+Loss 18304495
nsv829246 CNV Loss 20364138
dgv773n67 CNV Gain 20364138
dgv103e180 CNV Gain 20482838
essv20414 CNV CNV 17122850
dgv781e201 CNV Deletion 23290073
esv2659886 CNV Deletion 23128226
nsv436074 CNV Insertion 17901297
nsv511642 CNV Loss 21212237
nsv915179 CNV Gain 21882294
esv2658455 CNV Deletion 23128226

Relevant External Links for SERHL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERHL2 Gene

Disorders for SERHL2 Gene

Relevant External Links for SERHL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SERHL2: view

No data available for UniProtKB/Swiss-Prot for SERHL2 Gene

Publications for SERHL2 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for SERHL2 Gene

Sources for SERHL2 Gene

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