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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SERHL Gene

protein-coding GIFtS: 40
GCID: GC22P042896

serine hydrolase-like

Search for SERHL
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine Hydrolase-Like¹ ²		BK126B4.2²
BK126B4.1¹ ²		EC 3.1.-.-³
HS126B42¹ ²		SERHL2³
DJ222E13.1¹		SHL³

External Ids:	HGNC: 14408¹	Entrez Gene: 94009²	Ensembl: ENSG00000172250⁷	OMIM: 607979⁵	UniProtKB: Q9NQF3³

ORGUL members:
	NONCODE:n408025

Export aliases for SERHL gene to outside databases

Previous GC identifers: GC22P039499 GC22P041127 GC22P041221 GC22P025862

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3

Function: Putative serine hydrolase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SERHL gene promoter:
FOXF2 AML1a MyoD RelA NF-kappaB PPAR-gamma1 COMP1 PPAR-gamma2 NF-kappaB1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SERHL promoter sequence

Search SABiosciences Chromatin IP Primers for SERHL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERHL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2-q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2-q13.31

SERHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERHL gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P042896: view genomic region (about GC identifiers)

Start:	42,896,585 bp from pter	End:	42,908,566 bp from pter
Size:	11,982 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3 (See protein sequence)

Recommended Name: Serine hydrolase-like protein

Size: 203 amino acids; 22471 Da

Miscellaneous: This gene may have been partially duplicated (see SERHL2)

Secondary accessions: Q5JZ95 Q9UH21

Explore the universe of human proteins at neXtProt for SERHL: NX_Q9NQF3

SERHL Protein expression data from MOPED and PaxDb: --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

SERHL for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SERHL for domains About GeneDecksing

1 InterPro domain/family:

IPR000073 AB_hydrolase_1

Graphical View of Domain Structure for InterPro Entry Q9NQF3

ProtoNet protein and cluster: Q9NQF3

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3

Similarity: Belongs to the AB hydrolase superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3

Function: Putative serine hydrolase

Enzyme Number (IUBMB): EC 3.1.-.-¹

miRNA Products:		miRTarBase miRNAs that target SERHL: hsa-mir-346 (MIRT004221)

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0016787	hydrolase activity	IEA	--

SERHL for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SERHL

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

SERHL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SERHL
Search CenterWatch for drugs/clinical trials and news about SERHL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SERHL gene:

NM_170694.1

Unigene Cluster for SERHL:

Serine hydrolase-like

Hs.744111 [show with all ESTs]

Unigene Representative Sequence: AK094872

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455578(uc011apl.2 uc021wql.1) ENST00000359906 ENST00000434218

ENST00000421475

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Additional cDNA sequence:

AK094872.1 AL365513.1 BC093888.1 NR_027786.1

8 DOTS entries:

DT.451575 DT.208196 DT.99949605 DT.100834205 DT.100648969 DT.100834192 DT.120649679 DT.100834198

24/103 AceView cDNA sequences (see all 103):

BU684615 AL590118 AL590120 BM992883 CR626440 CD367673 H55243 BM824445

BM505049 NM_014509 AL450314 AL365513 NM_170694 CD723288 AK094872 BM704551

AA975753 BM473055 F03366 AA622993 CD625745 AI951241 Z40556 BM930864

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SERHL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCGAACCCC

About this image

SERHL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Genevestigator expression for SERHL

SOURCE GeneReport for Unigene cluster: Hs.744111

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for SERHL (if available)
TreeFam Gene Tree for SERHL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4822140^1,2	C,	--	42894585(+)	`aagtaC/Tagtac`	1	--	us2k¹		1		NA	2
rs138844373^1,2		--	42894608(+)	`AAGTAC/TAGTAT`	1	--	us2k¹		0	--	--	--	--
rs185112035^1,2		--	42894736(+)	`CTGCAA/CCAAAA`	1	--	us2k¹		0	--	--	--	--
rs56087170^1,2	C,	--	42894834(+)	`GAGGCG/CTAGAA`	1	--	us2k¹		1		NA	2
rs190588456^1,2		--	42894928(+)	`CACAAA/GGGTCG`	1	--	us2k¹		0	--	--	--	--
rs149544843^1,2		--	42894976(+)	`GGATAC/GGAATC`	1	--	us2k¹		0	--	--	--	--
rs56169883^1,2	F,	--	42895012(+)	`GCAAGT/ACCATT`	1	--	us2k¹		1		NA	120
rs147210575^1,2		--	42895021(+)	`TTCATA/CGGCTC`	1	--	us2k¹		0	--	--	--	--
rs140322232^1,2		--	42895063(+)	`GCTCAC/TTCTGG`	1	--	us2k¹		0	--	--	--	--
rs192965700^1,2		--	42895064(+)	`CTCATC/TCTGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SERHL (42896585 - 42908566 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for SERHL
10 CNVs: 38942 3242 32470 79585 7351 31094 79584 79588 4129 67897
4 Indels: 91072 91071 79583 79587

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SERHL for disorders About MalaCards

SERHL for disorders About GeneDecksing

OMIM gene information: 607979 OMIM disorders: --

Export disorders for SERHL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SERHL gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERHL)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)^{1, 2} Collins J.E.... Dunham I. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)¹ Collins J.E.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. (PubMed id 11352564)³ Sadusky T.J....Coulton G.R. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 94009	HGNC: 14408	AceView: dJ222E13.1andSERHL	Ensembl:ENSG00000172250	euGenes: HUgn94009
ECgene: SERHL	H-InvDB: SERHL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SERHL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SERHL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SERHL gene:
Search GeneIP for patents involving SERHL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Search ThermoFisher Antibodies for SERHL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SERHL gene at Home site.

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SERHL Gene

serine hydrolase-like

Aliases
for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

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Families
for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

Expression
for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

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for SERHL gene

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Advanced Search

Export list of displayed genes

SERHL Gene

serine hydrolase-like

Aliasesfor SERHL gene

Summariesfor SERHL gene

Genomic Viewsfor SERHL gene

Proteinsfor SERHL gene

Protein Domains /Familiesfor SERHL gene

Functionfor SERHL gene

Pathways & Interactionsfor SERHL gene

Drugs & Compoundsfor SERHL gene

Transcriptsfor SERHL gene

Expression for SERHL gene

Orthologsfor SERHL gene

Paralogsfor SERHL gene

Genomic Variantsfor SERHL gene

Disorders / Diseasesfor SERHL gene

Publicationsfor SERHL gene

External Searches for SERHL gene

Genome Databases showing SERHL gene

Other Databases showing SERHL gene

Specialized Databases showing SERHL gene

Intellectual Propertyfor SERHL gene

Productsfor SERHL gene

View Random Gene

Aliases
for SERHL gene

Summaries
for SERHL gene

Genomic Views
for SERHL gene

Proteins
for SERHL gene

Protein Domains /
Families
for SERHL gene

Function
for SERHL gene

Pathways & Interactions
for SERHL gene

Drugs & Compounds
for SERHL gene

Transcripts
for SERHL gene

Expression
for SERHL gene

Orthologs
for SERHL gene

Paralogs
for SERHL gene

Genomic Variants
for SERHL gene

Disorders / Diseases
for SERHL gene

Publications
for SERHL gene

Intellectual Property
for SERHL gene

Products
for SERHL gene