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SERHL Gene

protein-coding   GIFtS: 40
GCID: GC22P042896

Serine Hydrolase-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine Hydrolase-Like1 2     dJ222E13.12
kraken-like1     EC 3.1.-.-3
BK126B4.12     SERHL23
BK126B4.22     SHL3
HS126B422     

External Ids:    HGNC: 144081   Entrez Gene: 940092   Ensembl: ENSG000001722507   OMIM: 6079795   UniProtKB: Q9NQF33   

Export aliases for SERHL gene to outside databases

Previous GC identifers: GC22P039499 GC22P041127 GC22P041221 GC22P025862


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERHL Gene:
SERHL (serine hydrolase-like) is a protein-coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3
Function: Putative serine hydrolase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERHL gene promoter:
         FOXF2   AML1a   MyoD   RelA   NF-kappaB   PPAR-gamma1   COMP1   PPAR-gamma2   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERHL promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERHL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2-q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2-q13.31

SERHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERHL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P042896:  view genomic region     (about GC identifiers)

Start:
42,896,585 bp from pter      End:
42,908,566 bp from pter
Size:
11,982 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3 (See protein sequence)
Recommended Name: Serine hydrolase-like protein  
Size: 203 amino acids; 22471 Da
Miscellaneous: This gene may have been partially duplicated (see SERHL2)
Secondary accessions: Q5JZ95 Q9UH21

Explore the universe of human proteins at neXtProt for SERHL: NX_Q9NQF3

Explore proteomics data for SERHL at MOPED


See SERHL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR000073 AB_hydrolase_1

Graphical View of Domain Structure for InterPro Entry Q9NQF3

ProtoNet protein and cluster: Q9NQF3

UniProtKB/Swiss-Prot: SERHL_HUMAN, Q9NQF3
Similarity: Belongs to the AB hydrolase superfamily


Find genes that share domains with SERHL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SERHL_HUMAN, Q9NQF3
Function: Putative serine hydrolase

     Enzyme Number (IUBMB): EC 3.1.-.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0016787hydrolase activity IEA--
     
Find genes that share ontologies with SERHL           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
peroxisome3
nucleus2
cytosol1
extracellular1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

Find genes that share ontologies with SERHL           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for SERHL

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

Find genes that share ontologies with SERHL           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SERHL gene: 
NM_170694.1  

Unigene Cluster for SERHL:

Serine hydrolase-like
Hs.360940  [show with all ESTs]
Unigene Representative Sequence: AK094872
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000455578(processed_transcript) ENST00000359906(processed_transcript) ENST00000434218(processed_transcript) ENST00000421475(processed_transcript)
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Additional mRNA sequence: 

AK094872.1 AL365513.1 BC093888.1 NR_027786.1 

8 DOTS entries:

DT.451575  DT.208196  DT.99949605  DT.100834205  DT.100648969  DT.100834192  DT.120649679  DT.100834198 

Selected AceView cDNA sequences (see all 103):

BM824445 BM505049 AL365513 NM_170694 BM992883 NM_014509 AA975753 BU684615 
CD367673 CD723288 CR626440 H55243 BM473055 AL590120 BM704551 AL450314 
AL590118 AK094872 AI951241 AA622993 F03366 CD625745 BV188109 BX398944 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SERHL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCGAACCCC
SERHL Expression
About this image


SERHL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Primitive Streak (Early Embryonic Tissues)
         Primitive streak-like cells
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 NULL (Uncategorized)
         Definitive endoderm-like cells
 
 Gonad
         Secondary Oocyte Antral Follicle
 
 Endoderm (Gastrulation Derivatives)
         Definitive endoderm-like cells
SERHL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SERHL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.360940
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for SERHL (if available)
TreeFam Gene Tree for SERHL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SERHL gene
1 SIMAP similar gene for SERHL using alignment to 1 protein entry:     SERHL_HUMAN:
SERHL2

Find genes that share paralogs with SERHL           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SERHL (see all 201)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs48221401,2
C--42894585(+) aagtaC/Tagtac 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1388443731,2
C--42894608(+) AAGTAC/TAGTAT 1 -- us2k10--------
rs1851120351,2
--42894736(+) CTGCAA/CCAAAA 1 -- us2k10--------
rs560871701,2
C,F--42894834(+) GAGGCG/CTAGAA 1 -- us2k11Minor allele frequency- C:0.50NA 2
rs1905884561,2
--42894928(+) CACAAA/GGGTCG 1 -- us2k10--------
rs1495448431,2
--42894976(+) GGATAC/GGAATC 1 -- us2k10--------
rs561698831,2
F--42895012(+) GCAAGT/ACCATT 1 -- us2k11Minor allele frequency- A:0.10NA 120
rs1472105751,2
--42895021(+) TTCATA/CGGCTC 1 -- us2k10--------
rs1403222321,2
--42895063(+) GCTCAC/TTCTGG 1 -- us2k10--------
rs1929657001,2
C--42895064(+) CTCATC/TCTGGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SERHL (42896585 - 42908566 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SERHL (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
esv2724283CNV Deletion23290073
esv2659886CNV Deletion23128226
dgv781e201CNV Deletion23290073
nsv829246CNV Loss20364138
dgv773n67CNV Gain20364138
esv28197CNV Gain19812545
nsv428391CNV Gain18775914
dgv103e180CNV Gain20482838
esv32632CNV Gain17666407
nsv9912CNV Gain+Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607979    OMIM disorders: --


Find genes that share disorders with SERHL           About GenesLikeMe


Export disorders for SERHL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SERHL gene integrated from 10 sources:
(articles sorted by number of sources associating them with SERHL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
  3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (Genome Biol. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. (PubMed id 11352564)3 Sadusky T.J....Coulton G.R. (Genomics 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94009 HGNC: 14408 AceView: dJ222E13.1andSERHL Ensembl:ENSG00000172250 euGenes: HUgn94009
ECgene: SERHL H-InvDB: SERHL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SERHL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SERHL gene:
Search GeneIP for patents involving SERHL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 ELISAs for SERHL
 CLIAs for SERHL



 Browse ESI BIO Cell Lines and PureStem Progenitors for SERHL
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERHL
 SwitchGear 3'UTR luciferase reporter plasmids for SERHL
 SwitchGear Promoter luciferase reporter plasmids for SERHL
 Search ThermoFisher Antibodies for SERHL
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERHL
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERHL
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERHL
 Search LSBio for Antibodies for SERHL
 Browse compounds at ApexBio
 Search Addgene for plasmids for SERHL
  Search eBioscience for proteins for SERHL
  Search eBioscience for elisas for SERHL
  eBioscience FlowRNA Probe Sets
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 antibodies-online antibodies for SERHL (12 products)
 antibodies-online kits for SERHL (4 products)
 antibodies-online peptides for SERHL
 antibodies-online proteins for SERHL (6 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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