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SERGEF Gene

protein-coding   GIFtS: 52
GCID: GC11M017767

Secretion Regulating Guanine Nucleotide Exchange Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Secretion Regulating Guanine Nucleotide Exchange Factor1 2     Deafness Locus Associated Putative Guanine Nucleotide Exchange Factor2
DELGEF2 3 5     Secretion-Regulating Guanine Nucleotide Exchange Factor2
Deafness Locus-Associated Putative Guanine Nucleotide Exchange Factor2 3     DelGEF3
Guanine Nucleotide Exchange Factor-Related Protein2 3     GNEFR3
Gnefr2     

External Ids:    HGNC: 174991   Entrez Gene: 262972   Ensembl: ENSG000001291587   OMIM: 6060515   UniProtKB: Q9UGK83   
ORGUL members:         

Export aliases for SERGEF gene to outside databases

Previous GC identifer: GC11M017492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERGEF Gene:
SERGEF (secretion regulating guanine nucleotide exchange factor) is a protein-coding gene. Diseases associated with SERGEF include retinitis pigmentosa, and retinitis. GO annotations related to this gene include Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RCC2.

UniProtKB/Swiss-Prot: SRGEF_HUMAN, Q9UGK8
Function: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERGEF gene promoter:
         TBP   RFX1   Tal-1   Nkx2-5   Tal-1beta   LCR-F1   HNF-4alpha1   E47   Arnt   PPAR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERGEF promoter sequence
   Search Chromatin IP Primers for SERGEF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERGEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p14.3

SERGEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERGEF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M017767:  view genomic region     (about GC identifiers)

Start:
17,809,595 bp from pter      End:
18,034,709 bp from pter
Size:
225,115 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRGEF_HUMAN, Q9UGK8 (See protein sequence)
Recommended Name: Secretion-regulating guanine nucleotide exchange factor  
Size: 458 amino acids; 48981 Da
Subunit: Interacts with SEC5. The interaction occurs only in the presence of magnesium or manganese and is
stimulated by dCTP or GTP
Secondary accessions: Q9UGK9
Alternative splicing: 2 isoforms:  Q9UGK8-1   Q9UGK8-2   

Explore the universe of human proteins at neXtProt for SERGEF: NX_Q9UGK8

Explore proteomics data for SERGEF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SERGEF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036271.1  
    ENSEMBL proteins: 
     ENSP00000431490   ENSP00000434330   ENSP00000265965   ENSP00000434188   ENSP00000436111  
     ENSP00000432763   ENSP00000436648   ENSP00000431314   ENSP00000435003   ENSP00000437297  
     ENSP00000436080   ENSP00000435898   ENSP00000433870   ENSP00000433383   ENSP00000433884  

    SERGEF Human Recombinant Protein Products:

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    OriGene MassSpec for SERGEF
    OriGene Custom Protein Services for SERGEF
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    Novus Biologicals SERGEF Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SERGEF

    SERGEF Antibody Products:

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    SERGEF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SERGEF
    Cloud-Clone Corp. CLIAs for SERGEF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR000408 Reg_chr_condens
     IPR027048 DelGEF

    Graphical View of Domain Structure for InterPro Entry Q9UGK8

    ProtoNet protein and cluster: Q9UGK8

    UniProtKB/Swiss-Prot: SRGEF_HUMAN, Q9UGK8
    Similarity: Contains 7 RCC1 repeats


    SERGEF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRGEF_HUMAN, Q9UGK8
    Function: Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005087Ran guanyl-nucleotide exchange factor activity TAS10571079
    GO:0005515protein binding IPI12459492
         
    SERGEF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SERGEF:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERGEF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SERGEF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERGEF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERGEF

    miRNA
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    miRTarBase miRNAs that target SERGEF:
    hsa-mir-24-3p (MIRT030574)

    Block miRNA regulation of human, mouse, rat SERGEF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SERGEF
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERGEF
    Predesigned siRNA for gene silencing in human, mouse, rat SERGEF

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SERGEF

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERGEF (NM_012139)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERGEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERGEF

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERGEF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRGEF_HUMAN, Q9UGK8: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA10571079
    GO:0045111intermediate filament cytoskeleton IDA--

    SERGEF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERGEF
    Interactions:

        GeneGlobe Interaction Network for SERGEF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SERGEF (Q9UGK81, 3 ENSP000002659654) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPH3Q96FX21, 3, ENSP000004195994EBI-465368,EBI-465363 I2D: score=2 STRING: ENSP00000419599
    EXOC2Q96KP13, ENSP000002304494I2D: score=3 STRING: ENSP00000230449
    KDM1AO603411EBI-465368,EBI-710124
    PRMT6Q96LA81EBI-465368,EBI-912440
    ELP3ENSP000002563984STRING: ENSP00000256398
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10571079
    GO:0032316regulation of Ran GTPase activity TAS10571079
    GO:0050709negative regulation of protein secretion IDA12459492

    SERGEF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERGEF (SRGEF)

    5 HMDB Compounds for SERGEF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    1 Novoseek inferred chemical compound relationship for SERGEF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 51.7 2 12459492 (1)



    SERGEF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SERGEF gene: 
    NM_012139.3  

    Unigene Cluster for SERGEF:

    Secretion regulating guanine nucleotide exchange factor
    Hs.32470  [show with all ESTs]
    Unigene Representative Sequence: BC000707
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000531299 ENST00000531926 ENST00000528369 ENST00000527494 ENST00000525422(uc009yhd.3)
    ENST00000265965(uc001mnm.3 uc001mnn.3) ENST00000528200 ENST00000524589
    ENST00000529440 ENST00000529151 ENST00000532546 ENST00000525920 ENST00000532265(uc010rcz.1)
    ENST00000533241 ENST00000525168 ENST00000529728 ENST00000530613 ENST00000532389

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate SERGEF
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SERGEF
    Predesigned siRNA for gene silencing in human, mouse, rat SERGEF
    Clone
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    OriGene ORF clones in mouse, rat for SERGEF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SERGEF (NM_012139)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERGEF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERGEF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SERGEF
    OriGene qSTAR qPCR primer pairs in human, mouse for SERGEF
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SERGEF
      QuantiTect SYBR Green Assays in human, mouse, rat SERGEF
      QuantiFast Probe-based Assays in human, mouse, rat SERGEF

    Additional mRNA sequence: 

    AF086056.1 AJ243950.1 AJ243951.1 AK292286.1 AK294022.1 BC000707.2 BC065375.1 

    17 DOTS entries:

    DT.454501  DT.120695728  DT.95114296  DT.95114303  DT.100789260  DT.100008404  DT.100789257  DT.91712831 
    DT.100018476  DT.120695632  DT.92008532  DT.95114286  DT.100708495  DT.100789256  DT.100789263  DT.100789264 
    DT.86853095 

    Selected AceView cDNA sequences (see all 177):

    AW770701 BE502932 BM451912 BC000707 BQ059321 N47569 X52836 AI824319 
    AJ243951 BG756369 F08752 AW026847 BQ056935 AI356576 NM_004179 AI880317 
    AI570539 AI914248 AI216588 CB133049 AI733159 BM725728 BP382405 AW589305 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SERGEF (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                      -                                         -                                 
    SP2:                                      -                                         -     -                           
    SP3:                                      -                                   -     -     -           -     -         
    SP4:                                                                                -     -                           
    SP5:                                                              -     -     -     -     -           -     -         


    ECgene alternative splicing isoforms for SERGEF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERGEF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAAGAGA
    SERGEF Expression
    About this image

    SERGEF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERGEF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32470
        Custom PCR Arrays for SERGEF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERGEF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SERGEF gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sergef1 , 5 secretion regulating guanine nucleotide exchange factor1, 5 81.13(n)1
    75.64(a)1
      7 (30.20 cM)5
    274141  NM_013789.21  NP_038817.11 
     464431685 
    chicken
    (Gallus gallus)
    Aves SERGEF1 secretion regulating guanine nucleotide exchange factor 67.56(n)
    63.1(a)
      423077  XM_004941419.1  XP_004941476.1 
    lizard
    (Anolis carolinensis)
    Reptilia SERGEF6
    secretion regulating guanine nucleotide exchange f...
    58(a)
    1 ↔ 1
    1(67520121-67632951)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.142642 Transcribed sequence with weak similarity to protein more 77.78(n)    BX695855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sergef1 secretion regulating guanine nucleotide exchange factor 53.71(n)
    51.74(a)
      565673  XM_688940.4  XP_694032.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74201 CG7420 45.03(n)
    34.5(a)
      33332  NM_134758.4  NP_608602.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATS11 ATS1 42.64(n)
    30.74(a)
      851213   NP_009382.2 


    ENSEMBL Gene Tree for SERGEF (if available)
    TreeFam Gene Tree for SERGEF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERGEF gene
    RCC22  RCBTB22  IBTK2  WBSCR162  RCC12  RPGR2  RCBTB12  
    1 SIMAP similar gene for SERGEF using alignment to 14 protein entries:     SRGEF_HUMAN (see all proteins):
    HERC3

    SERGEF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERGEF (see all 3513)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833150311,2
    --17733223(+) CTCCAC/TCCCTA 1 -- int10--------
    rs1879526181,2
    --17733295(+) CCAGTC/GATCTG 1 -- int10--------
    rs1450474131,2
    C--17733334(+) GAAAAC/TCATGT 1 -- int10--------
    rs1912017531,2
    --17733434(+) CCAAAA/TTAATG 1 -- int10--------
    rs12362071,2
    C,F,H--17733454(+) GAACTG/AGGTTT 1 -- int119Minor allele frequency- A:0.12MN NS EA NA WA 2320
    rs1388924781,2
    --17733531(+) GTGAAG/TACCTA 1 -- int10--------
    rs1414134491,2
    C--17733591(+) CCCAGA/GCACTA 1 -- int10--------
    rs1504135781,2
    --17733613(+) TGCCAC/TCATTC 1 -- int10--------
    rs2011631021,2
    C--17733709(+) GCTTTC/TGGTGG 1 -- ut310--------
    rs107881,2,,4
    C,F,A,H--17733750(+) ACAGTC/TCCCCA 2 E G mis1 ese326Minor allele frequency- T:0.13MN NA NS EA WA EU 8637

    HapMap Linkage Disequilibrium report for SERGEF (17809595 - 18034709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SERGEF (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744165CNV Deletion23290073
    esv1127023CNV Deletion17803354
    esv989849CNV Deletion20482838
    esv2744163CNV Deletion23290073
    esv2744162CNV Deletion23290073
    esv5041CNV Deletion18987735
    esv1955784CNV Deletion18987734
    esv2101877CNV Deletion18987734
    nsv509390CNV Insertion20534489
    nsv832078CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606051    OMIM disorders: --

    3 diseases for SERGEF:    
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    retinitis pigmentosa    retinitis    malaria


    SERGEF for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERGEF

    Export disorders for SERGEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERGEF gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SERGEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. (PubMed id 12459492)1, 2, 3, 9 Sjoelinder M.... Ponstingl H. (FEBS Lett. 2002)
    2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. (PubMed id 10571079)1, 2, 3 Uhlmann J.... Ponstingl H. (FEBS Lett. 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. (PubMed id 14980502)1, 9 Sjoelinder M.... Ponstingl H. (Exp. Cell Res. 2004)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26297 HGNC: 17499 AceView: TPH1andDELGEF Ensembl:ENSG00000129158 euGenes: HUgn26297
    ECgene: SERGEF H-InvDB: SERGEF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERGEF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERGEF gene:
    Search GeneIP for patents involving SERGEF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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