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Aliases for SERGEF Gene

Aliases for SERGEF Gene

  • Secretion Regulating Guanine Nucleotide Exchange Factor 2 3
  • DELGEF 3 4 6
  • Deafness Locus-Associated Putative Guanine Nucleotide Exchange Factor 3 4
  • Guanine Nucleotide Exchange Factor-Related Protein 3 4
  • Gnefr 3 4
  • Deafness Locus Associated Putative Guanine Nucleotide Exchange Factor 3
  • Secretion-Regulating Guanine Nucleotide Exchange Factor 3

External Ids for SERGEF Gene

Previous GeneCards Identifiers for SERGEF Gene

  • GC11M017492

Summaries for SERGEF Gene

GeneCards Summary for SERGEF Gene

SERGEF (Secretion Regulating Guanine Nucleotide Exchange Factor) is a Protein Coding gene. GO annotations related to this gene include Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RCBTB2.

UniProtKB/Swiss-Prot for SERGEF Gene

  • Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERGEF Gene

Genomics for SERGEF Gene

Regulatory Elements for SERGEF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SERGEF Gene

Start:
17,788,048 bp from pter
End:
18,013,162 bp from pter
Size:
225,115 bases
Orientation:
Minus strand

Genomic View for SERGEF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERGEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERGEF Gene

Proteins for SERGEF Gene

  • Protein details for SERGEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGK8-SRGEF_HUMAN
    Recommended name:
    Secretion-regulating guanine nucleotide exchange factor
    Protein Accession:
    Q9UGK8
    Secondary Accessions:
    • Q9UGK9

    Protein attributes for SERGEF Gene

    Size:
    458 amino acids
    Molecular mass:
    48981 Da
    Quaternary structure:
    • Interacts with SEC5. The interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP.

    Alternative splice isoforms for SERGEF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERGEF Gene

Proteomics data for SERGEF Gene at MOPED

Post-translational modifications for SERGEF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SERGEF Gene

Domains for SERGEF Gene

Protein Domains for SERGEF Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGK8

UniProtKB/Swiss-Prot:

SRGEF_HUMAN :
  • Q9UGK8
Similarity:
  • Contains 7 RCC1 repeats.
genes like me logo Genes that share domains with SERGEF: view

No data available for Gene Families for SERGEF Gene

Function for SERGEF Gene

Molecular function for SERGEF Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process

Gene Ontology (GO) - Molecular Function for SERGEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005087 Ran guanyl-nucleotide exchange factor activity TAS 10571079
GO:0005515 protein binding IPI 12459492
genes like me logo Genes that share ontologies with SERGEF: view

Phenotypes for SERGEF Gene

GenomeRNAi human phenotypes for SERGEF:
genes like me logo Genes that share phenotypes with SERGEF: view

Animal Model Products

miRNA for SERGEF Gene

miRTarBase miRNAs that target SERGEF

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERGEF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERGEF Gene

Localization for SERGEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERGEF Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERGEF Gene COMPARTMENTS Subcellular localization image for SERGEF gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for SERGEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 10571079
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with SERGEF: view

Pathways for SERGEF Gene

SuperPathways for SERGEF Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERGEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10571079
GO:0043547 positive regulation of GTPase activity TAS 10571079
GO:0050709 negative regulation of protein secretion IDA 12459492
genes like me logo Genes that share ontologies with SERGEF: view

No data available for Pathways by source for SERGEF Gene

Compounds for SERGEF Gene

(5) HMDB Compounds for SERGEF Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(1) Novoseek inferred chemical compound relationships for SERGEF Gene

Compound -log(P) Hits PubMed IDs
gtp 51.7 1
genes like me logo Genes that share compounds with SERGEF: view

Transcripts for SERGEF Gene

Unigene Clusters for SERGEF Gene

Secretion regulating guanine nucleotide exchange factor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERGEF

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERGEF Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for SERGEF Gene

GeneLoc Exon Structure for
SERGEF
ECgene alternative splicing isoforms for
SERGEF

Expression for SERGEF Gene

mRNA expression in normal human tissues for SERGEF Gene

Protein differential expression in normal tissues for SERGEF Gene

This gene is overexpressed in Retina (31.0), Pancreas (13.2), and CD8 Tcells (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERGEF Gene

SOURCE GeneReport for Unigene cluster for SERGEF Gene Hs.32470

genes like me logo Genes that share expressions with SERGEF: view

Expression partners for SERGEF Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERGEF Gene

Orthologs for SERGEF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SERGEF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERGEF 35
  • 84.57 (n)
  • 79.91 (a)
SERGEF 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERGEF 35
  • 88.81 (n)
  • 84.93 (a)
mouse
(Mus musculus)
Mammalia Sergef 35
  • 81.13 (n)
  • 75.64 (a)
Sergef 16
Sergef 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERGEF 35
  • 99.34 (n)
  • 98.47 (a)
SERGEF 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sergef 35
  • 80.66 (n)
  • 76.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SERGEF 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERGEF 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERGEF 35
  • 67.56 (n)
  • 63.1 (a)
SERGEF 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERGEF 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC146459 35
  • 56.73 (n)
  • 49.36 (a)
Str.14264 35
zebrafish
(Danio rerio)
Actinopterygii sergef 35
  • 53.71 (n)
  • 51.74 (a)
sergef 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008272 35
  • 45.31 (n)
  • 37.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7420 35
  • 45.03 (n)
  • 34.5 (a)
CG7420 36
  • 30 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15906g 35
  • 42.84 (n)
  • 30.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATS1 35
  • 42.64 (n)
  • 30.74 (a)
SRM1 36
  • 16 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00469 35
  • 44.21 (n)
  • 34.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.04 35
  • 44.52 (n)
  • 31.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2363 36
  • 16 (a)
ManyToMany
Species with no ortholog for SERGEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERGEF Gene

ENSEMBL:
Gene Tree for SERGEF (if available)
TreeFam:
Gene Tree for SERGEF (if available)

Paralogs for SERGEF Gene

Paralogs for SERGEF Gene

genes like me logo Genes that share paralogs with SERGEF: view

Variants for SERGEF Gene

Sequence variations from dbSNP and Humsavar for SERGEF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1528 - 17,788,177(+) GGCTT(C/T)CTGAG reference, missense, nc-transcript-variant
rs10788 - 17,788,092(+) ACAGT(C/T)CCCCA missense, reference, nc-transcript-variant
rs95807 -- 17,949,368(-) CCTTG(C/T)TGTTT intron-variant
rs121704 -- 17,883,087(+) ACCTC(A/G)GCCTG intron-variant
rs169807 -- 17,983,216(+) CTGAC(A/C)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERGEF Gene

Variant ID Type Subtype PubMed ID
nsv509390 CNV Insertion 20534489
nsv516767 CNV Loss 19592680
nsv832078 CNV Loss 17160897
nsv515890 CNV Loss 19592680
nsv526501 CNV Loss 19592680
nsv897026 CNV Gain 21882294
esv1955784 CNV Deletion 18987734
esv2744162 CNV Deletion 23290073
nsv832079 CNV Loss 17160897
esv2744163 CNV Deletion 23290073
esv5041 CNV Deletion 18987735
esv2101877 CNV Deletion 18987734
esv2744165 CNV Deletion 23290073
esv989849 CNV Deletion 20482838
esv1127023 CNV Deletion 17803354

Relevant External Links for SERGEF Gene

HapMap Linkage Disequilibrium report
SERGEF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERGEF Gene

Disorders for SERGEF Gene

Relevant External Links for SERGEF

Genetic Association Database (GAD)
SERGEF

No disorders were found for SERGEF Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SERGEF Gene

Publications for SERGEF Gene

  1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. (PMID: 12459492) Sjoelinder M. … Ponstingl H. (FEBS Lett. 2002) 2 3 4 23
  2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. (PMID: 10571079) Uhlmann J. … Ponstingl H. (FEBS Lett. 1999) 2 3 4
  3. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. (PMID: 14980502) Sjoelinder M. … Ponstingl H. (Exp. Cell Res. 2004) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for SERGEF Gene

Sources for SERGEF Gene

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