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Aliases for SERF2 Gene

Aliases for SERF2 Gene

  • Small EDRK-Rich Factor 2 2 3 5
  • Gastric Cancer-Related Protein VRG107 3 4
  • Protein 4F5-Related 3 4
  • H4F5REL 3 4
  • 4F5REL 3 4
  • FAM2C 3 4
  • HsT17089 3

External Ids for SERF2 Gene

Previous GeneCards Identifiers for SERF2 Gene

  • GC15P039436
  • GC15P036965
  • GC15P041648
  • GC15P041785
  • GC15P041856
  • GC15P044069
  • GC15P020907

Summaries for SERF2 Gene

GeneCards Summary for SERF2 Gene

SERF2 (Small EDRK-Rich Factor 2) is a Protein Coding gene.

Gene Wiki entry for SERF2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERF2 Gene

Genomics for SERF2 Gene

Regulatory Elements for SERF2 Gene

Enhancers for SERF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERF2 on UCSC Golden Path with GeneCards custom track

Promoters for SERF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERF2 Gene

43,777,087 bp from pter
43,802,589 bp from pter
25,503 bases
Plus strand

Genomic View for SERF2 Gene

Genes around SERF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERF2 Gene

Proteins for SERF2 Gene

  • Protein details for SERF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small EDRK-rich factor 2
    Protein Accession:
    Secondary Accessions:
    • A6NL45
    • B5MCG1
    • B9A026
    • O75918
    • O88891
    • Q9BZH7

    Protein attributes for SERF2 Gene

    59 amino acids
    Molecular mass:
    6900 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK07636.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for SERF2 Gene


neXtProt entry for SERF2 Gene

Proteomics data for SERF2 Gene at MOPED

Post-translational modifications for SERF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SERF2 Gene

Domains & Families for SERF2 Gene

Protein Domains for SERF2 Gene


Suggested Antigen Peptide Sequences for SERF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SERF family.
  • Belongs to the SERF family.
genes like me logo Genes that share domains with SERF2: view

No data available for Gene Families for SERF2 Gene

Function for SERF2 Gene

Phenotypes for SERF2 Gene

GenomeRNAi human phenotypes for SERF2:
genes like me logo Genes that share phenotypes with SERF2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERF2 Gene

Localization for SERF2 Gene

Subcellular locations from

Jensen Localization Image for SERF2 Gene COMPARTMENTS Subcellular localization image for SERF2 gene
Compartment Confidence
cytosol 4
nucleus 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SERF2 Gene

Pathways & Interactions for SERF2 Gene

SuperPathways for SERF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SERF2 Gene

Drugs & Compounds for SERF2 Gene

No Compound Related Data Available

Transcripts for SERF2 Gene

Unigene Clusters for SERF2 Gene

Small EDRK-rich factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP8: - - -
SP9: -
SP10: - - - -

Relevant External Links for SERF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERF2 Gene

mRNA expression in normal human tissues for SERF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.4) and Ovary (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERF2 Gene

SOURCE GeneReport for Unigene cluster for SERF2 Gene Hs.424126

genes like me logo Genes that share expression patterns with SERF2: view

Protein tissue co-expression partners for SERF2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SERF2 Gene

Orthologs for SERF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SERF2 35
  • 99.44 (n)
  • 100 (a)
(Canis familiaris)
Mammalia SERF2 35
  • 99.44 (n)
  • 100 (a)
SERF2 36
  • 98 (a)
(Mus musculus)
Mammalia Serf2 35
  • 97.74 (n)
  • 100 (a)
Serf2 16
(Pan troglodytes)
Mammalia SERF2 35
  • 100 (n)
  • 100 (a)
ptr-mir-1282-1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Serf2 35
  • 97.74 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5567 35
(Danio rerio)
Actinopterygii Dr.14289 35
Species with no ortholog for SERF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERF2 Gene

Gene Tree for SERF2 (if available)
Gene Tree for SERF2 (if available)

Paralogs for SERF2 Gene

(2) SIMAP similar genes for SERF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SERF2: view

No data available for Paralogs for SERF2 Gene

Variants for SERF2 Gene

Sequence variations from dbSNP and Humsavar for SERF2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_051937 -
rs7166696 -- 43,780,252(+) ctcct(C/G)cctca intron-variant
rs12899922 -- 43,788,377(+) cgcct(C/T)ggtct intron-variant
rs58518347 -- 43,786,434(+) AAAAA(-/A)GCTGG intron-variant
rs7180818 -- 43,783,061(+) gtagt(A/G)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERF2 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850

Variation tolerance for SERF2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERF2 Gene

Disorders for SERF2 Gene

Relevant External Links for SERF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERF2 Gene

Publications for SERF2 Gene

  1. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. (PMID: 9731538) Scharf J.M. … Kunkel L.M. (Nat. Genet. 1998) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. (PMID: 20723760) van Ham T.J. … Nollen E.A. (Cell 2010) 3
  4. Blocking BE301622 gene expression by RNAi initiates differentiation of neural stem cells in rat. (PMID: 16927404) Wen T. … Li H. (Cell Biochem. Funct. 2007) 3
  5. Structured RNAs in the ENCODE selected regions of the human genome. (PMID: 17568003) Washietl S. … Stadler P.F. (Genome Res. 2007) 3

Products for SERF2 Gene

Sources for SERF2 Gene