SERF1B Gene
protein-coding GIFtS: 44
GCID: GC05P069322
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small EDRK-rich factor 1B (centromeric)
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Aliases
for SERF1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small EDRK-Rich Factor 1B (Centromeric)1 2 | | SMA Modifier 12 3 | | FAM2B1 2 3 | | Small EDRK-Rich Factor 12 | | H4F5C1 2 | | FAM2A3 | | Protein 4F52 3 | | SERF13 | | H4F51 | | SMAM13 |
Export aliases for SERF1B gene to outside databasesPrevious GC identifers: GC05M069157 GC05M035205 GC05P069810 GC05P069856 GC05P069857 GC05P070232 GC05U900528 GC05P069358 GC05P065845 |
Summaries
for SERF1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SERF1B:
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least fourgenes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexityof the sequence have also caused difficulty in determining the organization of this genomic region. This gene is thecentromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented butit is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The geneencodes a protein of unknown function which bears low-level homology with the RNA-binding domain ofmatrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 geneproduct. (provided by RefSeq, Jul 2008)
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Genomic Views
for SERF1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SERF1B gene promoter:
Nkx2-2 CUTL1 IRF-2 POU2F1 FOXJ2 (long isoform) POU2F1a Chx10 STAT3 FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SERF1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERF1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13.2 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13SERF1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P069322: view genomic region
(about GC identifiers)
Start:
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69,321,074 bp from pter |
End:
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69,338,940 bp from pter |
Size:
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17,867 bases |
Orientation:
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plus strand |
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Proteins
for SERF1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SERF1_HUMAN, O75920 (See
protein sequence)Recommended Name: Small EDRK-rich factor 1 Size: 110 amino acids; 12349 Da
Secondary accessions: B7ZKM2 O75919 Q52LK5Alternative splicing: 2 isoforms: O75920-1 O75920-2 Explore the universe of human proteins at neXtProt for SERF1B: NX_O75920
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75920
SERF1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171558.1 NP_075267.1
ENSEMBL proteins: ENSP00000370127 ENSP00000370126 ENSP00000423882 ENSP00000421563 ENSP00000427181
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SERF1B for ontologies About GeneDecksing
SERF1B Antibody Products:
Assay Products for SERF1B: |
Protein
Domains /
Families
for SERF1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SERF1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75920ProtoNet protein and cluster: O75920 1 Blocks protein family: IPB007513 Four F5 protein
UniProtKB/Swiss-Prot: SERF1_HUMAN, O75920Similarity: Belongs to the SERF family |
Function
for SERF1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERF1B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SERF1B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SERF1B:
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Pathways & Interactions
for SERF1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERF1B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SERF1B (O759203 ENSP000003701264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007399 | nervous system development |
TAS | 9731538 |
SERF1B for ontologies About GeneDecksing
|
Drugs & Compounds
for SERF1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SERF1B
Search CenterWatch for drugs/clinical trials and news about SERF1B / SERF1
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Transcripts
for SERF1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SERF1B gene (2 alternative transcripts): NM_001178087.1 NM_022978.2 Unigene Cluster for SERF1B: Small EDRK-rich factor 1B (centromeric) Hs.559428 [show with all ESTs]Unigene Representative Sequence: NM_0229788 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380751(uc003jxz.3) ENST00000380750(uc003jyb.3) ENST00000503931
ENST00000506542 ENST00000515588 ENST00000507177 ENST00000514285 ENST00000513144
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SERF1B (NM_022978) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SERF1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERF1B |
Additional cDNA sequence: BC101970.1 BC103687.1 BC104738.1 BC143255.1 BC143260.1 BC171749.1 15 DOTS entries: DT.214248 DT.95157164 DT.120845327 DT.92420310 DT.99985956 DT.453238 DT.120845152 DT.75118279 DT.101982577 DT.97762404 DT.97780241 DT.99975805 DT.100822322 DT.40264383 DT.97770443
GeneLoc Exon Structure
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Expression
for SERF1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SERF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SERF1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SERF1B
SOURCE GeneReport for Unigene cluster: Hs.559428
UniProtKB/Swiss-Prot: SERF1_HUMAN, O75920Tissue specificity: Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short andIsoform Long are expressed throughout the central nervous system, including spinal cord
SABiosciences Custom PCR Arrays for SERF1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERF1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SERF1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERF1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERF1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERF1B |
Orthologs
for SERF1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SERF1B gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for SERF1B (if available)
TreeFam Gene Tree for SERF1B (if available) |
Paralogs
for SERF1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SERF1B gene
- SERF1A1 2 SERF22
18/30 SIMAP similar genes for SERF1B using alignment to 4 protein entries: SERF1_HUMAN (see all proteins)
(see all similar genes):SERF1A SERF2 IFT122 IPO7 MKRN1 NSD1
CNOT2 KLHDC1 NDUFS7 SUMF2 FANCA HGSNAT
C11orf80 LRRC36 SCLT1 WDR69 C15orf40 CLEC2D
SERF1B for paralogs About GeneDecksing
|
Genomic Variants
for SERF1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SERF1B (69321074 - 69338940 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 41 variations for SERF1B
15/39 CNVs (see all 39): 4452 69103 69105 69085 4449 31241 69097 69087 32723 64227 93094 69093 37550 7500 69120
2 Inversions: 37264 37263 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SERF1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SERF1B for disorders About GeneDecksing
3  diseases for SERF1B: About MalaCardsspinal muscular atrophy muscular atrophy scrapie
2 diseases from the University of Copenhagen DISEASES database for SERF1B:Scrapie Spinal muscular atrophy Export disorders for SERF1B gene to outside databases
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Publications
for SERF1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SERF1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with SERF1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. (PubMed id 9731538)1, 2 Scharf J.M.... Kunkel L.M. (1998)
- Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061)1 Tomarev S.I....Malyukova I. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Comparative sequence analysis of the mouse and human Lgn1/SMA interval. (PubMed id 10486205)1 Endrizzi M....Dietrich W.F. (1999)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for SERF1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SERF1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SERF1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SERF1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SERF1B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SERF1B gene:
Search GeneIP for patents involving SERF1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SERF1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SERF1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SERF1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SERF1B | | | OriGene Protein Over-expression Lysate for SERF1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SERF1B | | OriGene 3'-UTR Clone for SERF1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SERF1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SERF1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SERF1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERF1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SERF1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERF1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERF1B |
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 | | | SERF1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERF1B |
|  |  |  | | | | Search ThermoFisher Antibodies for SERF1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERF1B |
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