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Aliases for SERBP1 Gene

Aliases for SERBP1 Gene

  • SERPINE1 MRNA Binding Protein 1 2 3 5
  • PAI1 RNA-Binding Protein 1 3 4
  • PAI-RBP1 3 4
  • PAIRBP1 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Plasminogen Activator Inhibitor 1 RNA-Binding Protein 3
  • SERPINE1 MRNA-Binding Protein 1 4
  • PAI-1 MRNA Binding Protein 3
  • CGI-55 3
  • CHD3IP 3
  • HABP4L 3

External Ids for SERBP1 Gene

Previous GeneCards Identifiers for SERBP1 Gene

  • GC01M067590
  • GC01M067873
  • GC01M065983

Summaries for SERBP1 Gene

GeneCards Summary for SERBP1 Gene

SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA 3-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot for SERBP1 Gene

  • May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Gene Wiki entry for SERBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERBP1 Gene

Genomics for SERBP1 Gene

Regulatory Elements for SERBP1 Gene

Enhancers for SERBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F067338 1.1 Ensembl ENCODE 11.2 +90.7 90691 2.9 TBP PKNOX1 WRNIP1 BMI1 ZNF366 CBX5 ETV6 FOS ZNF362 USF2 IL12RB2 SERBP1 RNU6-387P RNU4ATAC4P LOC105378779
GH01F067399 0.9 ENCODE 13.1 +30.1 30106 1.3 KLF17 PTRF ZNF2 ZNF366 SMARCA5 TSHZ1 HDAC8 MEF2D IRF1 ZNF24 SERBP1 RNU4ATAC4P LOC105378779 GC01P067418
GH01F067433 0.9 Ensembl 8.6 -3.5 -3461 1.8 HDAC1 PKNOX1 TBL1XR1 FEZF1 GATA2 SCRT2 SMARCA5 ZNF362 OVOL3 MBD2 SERBP1 PIR38616
GH01F067336 0.7 Ensembl ENCODE 10.8 +93.4 93399 1.1 HDGF CREM SERBP1 IL12RB2 RNU4ATAC4P LOC105378779
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SERBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SERBP1 Gene

67,407,810 bp from pter
67,430,440 bp from pter
22,631 bases
Minus strand

Genomic View for SERBP1 Gene

Genes around SERBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERBP1 Gene

Proteins for SERBP1 Gene

  • Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q5VU19
    • Q5VU20
    • Q5VU22
    • Q8WUH0
    • Q96SE2
    • Q9BTY3
    • Q9BUM4
    • Q9Y367
    • Q9Y4S3

    Protein attributes for SERBP1 Gene

    408 amino acids
    Molecular mass:
    44965 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3.

    Three dimensional structures from OCA and Proteopedia for SERBP1 Gene

    Alternative splice isoforms for SERBP1 Gene


neXtProt entry for SERBP1 Gene

Post-translational modifications for SERBP1 Gene

  • Ubiquitination at Lys 52, Lys 68, Lys 294, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for SERBP1 Gene

No data available for DME Specific Peptides for SERBP1 Gene

Domains & Families for SERBP1 Gene

Protein Domains for SERBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SERBP1 Gene

Function for SERBP1 Gene

Molecular function for SERBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Gene Ontology (GO) - Molecular Function for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 11001948
GO:0005515 protein binding IPI 12505151
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with SERBP1: view
genes like me logo Genes that share phenotypes with SERBP1: view

Animal Model Products

miRNA for SERBP1 Gene

miRTarBase miRNAs that target SERBP1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERBP1 Gene

Localization for SERBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SERBP1: view

Pathways & Interactions for SERBP1 Gene

SuperPathways for SERBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042981 regulation of apoptotic process IEA --
GO:0043488 regulation of mRNA stability NAS 11001948
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with SERBP1: view

No data available for Pathways by source and SIGNOR curated interactions for SERBP1 Gene

Transcripts for SERBP1 Gene

Unigene Clusters for SERBP1 Gene

SERPINE1 mRNA binding protein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERBP1 Gene

No ASD Table

Relevant External Links for SERBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SERBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SERBP1 Gene

Protein differential expression in normal tissues from HIPED for SERBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERBP1 Gene

Protein tissue co-expression partners for SERBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERBP1 Gene:


SOURCE GeneReport for Unigene cluster for SERBP1 Gene:


mRNA Expression by UniProt/SwissProt for SERBP1 Gene:

Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
genes like me logo Genes that share expression patterns with SERBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SERBP1 Gene

Orthologs for SERBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SERBP1 35
  • 100 (a)
(Bos Taurus)
Mammalia SERBP1 35
  • 99 (a)
(Canis familiaris)
Mammalia SERBP1 34 35
  • 96.92 (n)
(Mus musculus)
Mammalia Serbp1 34 16 35
  • 93.35 (n)
(Monodelphis domestica)
Mammalia SERBP1 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SERBP1 35
  • 88 (a)
(Gallus gallus)
Aves SERBP1 35
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
-- 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17049 34
African clawed frog
(Xenopus laevis)
Amphibia rda288-prov 34
(Danio rerio)
Actinopterygii serbp1a 35 35
  • 72 (a)
SERBP1 (3 of 3) 35
  • 66 (a)
Dr.383 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10597 34
fruit fly
(Drosophila melanogaster)
Insecta CG41503 35
  • 27 (a)
vig 35
  • 24 (a)
vig2 35
  • 23 (a)
Species where no ortholog for SERBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERBP1 Gene

Gene Tree for SERBP1 (if available)
Gene Tree for SERBP1 (if available)

Paralogs for SERBP1 Gene

Paralogs for SERBP1 Gene

(2) SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERBP1: view

Variants for SERBP1 Gene

Sequence variations from dbSNP and Humsavar for SERBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157981 -- 67,427,176(+) AGACC(A/G)CTTTT intron-variant
rs1058074 -- 67,410,801(-) AATCT(A/G)ATTGT utr-variant-3-prime
rs1060083 -- 67,408,460(-) TACCC(A/C)CACAA utr-variant-3-prime
rs1060085 -- 67,408,458(-) CCCAC(A/C)CAAGT utr-variant-3-prime
rs1064385 -- 67,412,823(-) TTAGA(A/G)GTTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERBP1 Gene

Variant ID Type Subtype PubMed ID
nsv1254 CNV insertion 18451855
nsv461773 CNV loss 19166990
nsv546447 CNV loss 21841781
nsv945985 CNV duplication 23825009

Variation tolerance for SERBP1 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERBP1 Gene

Disorders for SERBP1 Gene

Relevant External Links for SERBP1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SERBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERBP1 Gene

Publications for SERBP1 Gene

  1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton J.H. … Gelehrter T.D. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I. … Cote J. (Hum. Mol. Genet. 2008) 3 4 22 64
  3. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D. … Sehouli J. (Gynecol. Oncol. 2007) 2 3 22 64
  4. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos T.A. … Kobarg J. (FEBS Lett. 2003) 3 4 22 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64

Products for SERBP1 Gene

Sources for SERBP1 Gene

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