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SERBP1 Gene

protein-coding   GIFtS: 51
GCID: GC01M067873

SERPINE1 MRNA Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SERPINE1 MRNA Binding Protein 11 2     HABP4L2
PAI-RBP12 3     Chromodomain Helicase DNA Binding Protein 3 Interacting Protein2
PAIRBP12 3     PAI-1 MRNA Binding Protein2
PAI1 RNA-Binding Protein 12 3     Plasminogen Activator Inhibitor 1 RNA Binding Protein2
SERPINE1 MRNA-Binding Protein 12 3     Plasminogen Activator Inhibitor 1 RNA-Binding Protein2
CHD3IP2     

External Ids:    HGNC: 178601   Entrez Gene: 261352   Ensembl: ENSG000001428647   OMIM: 6073785   UniProtKB: Q8NC513   

Export aliases for SERBP1 gene to outside databases

Previous GC identifers: GC01M067590 GC01M065983


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SERBP1 Gene:
SERBP1 (SERPINE1 mRNA binding protein 1) is a protein-coding gene. GO annotations related to this gene include mRNA 3'-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot: PAIRB_HUMAN, Q8NC51
Function: May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1
mRNA, a region which confers cyclic nucleotide regulation of message decay

Gene Wiki entry for SERBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SERBP1 gene promoter:
         AhR   FOXF2   Bach2   Pax-2   Pax-4a   Tal-1beta   Arnt   Ik-1   E47   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERBP1 promoter sequence
   Search Chromatin IP Primers for SERBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SERBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

SERBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M067873:  view genomic region     (about GC identifiers)

Start:
67,873,493 bp from pter      End:
67,896,123 bp from pter
Size:
22,631 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAIRB_HUMAN, Q8NC51 (See protein sequence)
Recommended Name: Plasminogen activator inhibitor 1 RNA-binding protein  
Size: 408 amino acids; 44965 Da
Subunit: Interacts with CHD3 and TDRD3
1 PDB 3D structure from and Proteopedia for SERBP1:
3J3A (3D)    
Secondary accessions: Q5VU19 Q5VU20 Q5VU22 Q8WUH0 Q96SE2 Q9BTY3 Q9BUM4 Q9Y367 Q9Y4S3
Alternative splicing: 4 isoforms:  Q8NC51-1   Q8NC51-2   Q8NC51-3   Q8NC51-4   (Contains a phosphoserine at position 231. Contains a phosphothreonine at position 234)

Explore the universe of human proteins at neXtProt for SERBP1: NX_Q8NC51

Explore proteomics data for SERBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52, Lys68, Lys122, Lys236, Lys294, Lys320
  • Modification sites at PhosphoSitePlus

  • See SERBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001018077.1  NP_001018078.1  NP_001018079.1  NP_056455.3  

    ENSEMBL proteins: 
     ENSP00000360033   ENSP00000360034   ENSP00000354591   ENSP00000360029  

    SERBP1 Human Recombinant Protein Products:

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    Novus Biologicals SERBP1 Protein
    Novus Biologicals SERBP1 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SERBP1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027205 SERBP1
     IPR006861 HABP4_PAIRBP1-bd

    Graphical View of Domain Structure for InterPro Entry Q8NC51

    ProtoNet protein and cluster: Q8NC51


    Find genes that share domains with SERBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAIRB_HUMAN, Q8NC51
    Function: May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1
    mRNA, a region which confers cyclic nucleotide regulation of message decay

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding IDA11001948
    GO:0005515protein binding IPI12505151
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SERBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SERBP1:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SERBP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SERBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SERBP1:
    hsa-mir-10a-5p (MIRT025598), hsa-mir-615-3p (MIRT039718), hsa-mir-93-3p (MIRT038800), hsa-mir-100-5p (MIRT048435), hsa-let-7e-5p (MIRT051499), hsa-mir-625-5p (MIRT039591), hsa-mir-374a-5p (MIRT044015), hsa-let-7b-5p (MIRT052014), hsa-mir-16-5p (MIRT031433), hsa-mir-652-3p (MIRT039515), hsa-mir-18a-5p (MIRT050709), hsa-mir-27a-3p (MIRT050015), hsa-mir-505-3p (MIRT040989), hsa-mir-15b-5p (MIRT046390), hsa-mir-30b-5p (MIRT046130), hsa-mir-328-3p (MIRT043783), hsa-mir-26a-5p (MIRT002315)

    Block miRNA regulation of human, mouse, rat SERBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERBP1 (see all 154):
    hsa-miR-579 hsa-miR-100* hsa-miR-128 hsa-miR-605 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3921 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat SERBP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): SERBP1 (NM_001018069)
    Sino Biological Human cDNA Clone for SERBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERBP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAIRB_HUMAN, Q8NC51: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with SERBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SERBP1
    Interactions:

        Search GeneGlobe Interaction Network for SERBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SERBP1 (Q8NC511, 2, 3 ENSP000003600344) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITFG1Q8TB962, 3, ENSP000003199184MINT-8270209 I2D: score=2 STRING: ENSP00000319918
    VIMP086702, 3MINT-64988 I2D: score=4 
    DAXXQ9UER73, ENSP000003968764I2D: score=1 STRING: ENSP00000396876
    ENSG00000206206Q9UER73I2D: score=1 
    ENSG00000206279Q9UER73I2D: score=1 
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042981regulation of apoptotic process IEA--
    GO:0043488regulation of mRNA stability NAS11001948

    Find genes that share ontologies with SERBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SERBP1 (PAIRB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SERBP1 gene (4 alternative transcripts): 
    NM_001018067.1  NM_001018068.1  NM_001018069.1  NM_015640.3  

    Unigene Cluster for SERBP1:

    SERPINE1 mRNA binding protein 1
    Hs.530412  [show with all ESTs]
    Unigene Representative Sequence: NM_001018067
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370994(uc001ddy.3 uc001ddw.3 uc001ddx.3 uc001ddv.3)
    ENST00000370995 ENST00000361219 ENST00000370990 ENST00000493607 ENST00000462814
    ENST00000484880 ENST00000490406
    miRNA
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    Block miRNA regulation of human, mouse, rat SERBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SERBP1 (see all 154):
    hsa-miR-579 hsa-miR-100* hsa-miR-128 hsa-miR-605 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3921 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SERBP1
    Clone
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    OriGene clones in human, mouse for SERBP1 (see all 28)
    OriGene ORF clones in mouse, rat for SERBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SERBP1 (NM_001018069)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERBP1
    Primer
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    OriGene qPCR primer pairs and template standards for SERBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SERBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SERBP1
      QuantiTect SYBR Green Assays in human, mouse, rat SERBP1
      QuantiFast Probe-based Assays in human, mouse, rat SERBP1

    Additional mRNA sequence: 

    AF131807.1 AF151813.1 AK074970.1 AK095960.1 AK130606.1 AK222955.1 AK223138.1 AK312256.1 
    AL080119.1 AY032853.1 BC002488.2 BC003049.1 BC008045.2 BC017449.1 BC019273.1 BC020555.1 
    BC026916.1 BC036414.2 BX647139.1 CR457383.1 

    Selected DOTS entries (see all 63):

    DT.452915  DT.87015541  DT.100891205  DT.91699359  DT.100891225  DT.92360428  DT.100891198  DT.100040476 
    DT.100891222  DT.100891221  DT.100033842  DT.101985402  DT.443183  DT.121263321  DT.102838737  DT.100680339 
    DT.100891213  DT.121335052  DT.91718737  DT.121335097  DT.100891189  DT.100891214  DT.92467919  DT.101969765 

    Selected AceView cDNA sequences (see all 1440):

    AA035739 BQ421077 BE220410 AA456286 AA961611 CA394500 AA353066 CB115013 
    CR619466 AA580859 CR623194 N54677 BU902164 AI590932 AA760844 BM750429 
    BQ690962 CR607610 BC020555 BU687013 CA950380 BU159606 BQ001885 BU175375 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SERBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SERBP1 Expression
    About this image


    SERBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SERBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SERBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530412

    UniProtKB/Swiss-Prot: PAIRB_HUMAN, Q8NC51
    Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in
    placenta, liver and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SERBP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serbp11 , 5 serpine1 mRNA binding protein 11, 5 93.35(n)1
    98.5(a)1
      6 (30.80 cM)5
    668701  NM_001113564.11  NP_001107036.11 
     672669795 
    chicken
    (Gallus gallus)
    Aves SERBP16
    Gallus gallus SERPINE1 mRNA binding protein 1 (SER...
    88(a)
    1 ↔ 1
    8(27570552-27583269)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    82(a)
    1 ↔ many
    1 ↔ many
    GL344316.1(2505-11083)
    GL343328.1(47025-93471)
    African clawed frog
    (Xenopus laevis)
    Amphibia rda288-prov2 hypothetical protein MGC53445 77.78(n)    BC046574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.3832 Danio rerio mRNA similar to RIKEN cDNA 1200009K13 gene more 79.11(n)    BC046876.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG415036
    vig6
    (see all 3)
    vasa intronic gene
    (see all 3)
    27(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    YHet(305269-307004)
    2L(15062931-15070316)


    ENSEMBL Gene Tree for SERBP1 (if available)
    TreeFam Gene Tree for SERBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SERBP1 gene
    HABP42  
    2 SIMAP similar genes for SERBP1 using alignment to 3 protein entries:     PAIRB_HUMAN (see all proteins):
    DKFZp686P17171    HABP4

    Find genes that share paralogs with SERBP1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SERBP1 (see all 8)
    PGOHUM00000237501 PGOHUM00000244079 PGOHUM00000237630 PGOHUM00000245605 PGOHUM00000235205


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SERBP1 (see all 472)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857244731,2
    --67873042(+) GTGGCA/GGGCGC 4 -- ds50010--------
    rs1162357051,2
    F--67873058(+) ATTCTA/GGCTAC 4 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1878632341,2
    --67873159(+) CAGAGA/TGAGAC 4 -- ds50010--------
    rs1924451561,2
    --67873295(+) ATGTCA/GTCATG 4 -- ds50010--------
    rs19485261,2
    C,F,O,A,H--67873346(-) TTTTGG/TAAAGA 4 -- ds500117Minor allele frequency- T:0.02NA EA MN NS 1702
    rs19485251,2
    C,F,H--67873451(-) ACAAAG/AAAATG 4 -- ds500111Minor allele frequency- A:0.01MN NS EA NA 1504
    rs1841058921,2
    --67873459(+) TGTGGA/GTTACG 4 -- ds50010--------
    rs1887396501,2
    --67873464(+) GTTACA/GTGTAA 4 -- ds50010--------
    rs1815171091,2
    --67873486(+) CAATAC/TACAAA 4 -- ds50010--------
    rs1845640541,2
    --67873492(+) ACAAAA/GTTCCC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERBP1 (67873493 - 67896123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SERBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1254CNV Insertion18451855
    nsv461773CNV Loss19166990
    nsv871374CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607378    OMIM disorders: --


    Find genes that share disorders with SERBP1           About GenesLikeMe

    Genetic Association Database (GAD): SERBP1

    Export disorders for SERBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SERBP1 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with SERBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. (PubMed id 11001948)1, 2, 3, 9 Heaton J.H.... Gelehrter T.D. (J. Biol. Chem. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PubMed id 17698176)1, 3, 9 Koensgen D....Sehouli J. (Gynecol. Oncol. 2007)
    4. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PubMed id 12505151)1, 2, 9 Lemos T.A.... Kobarg J. (FEBS Lett. 2003)
    5. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PubMed id 18632687)1, 2, 9 Goulet I.... Cote J. (Hum. Mol. Genet. 2008)
    6. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. (PubMed id 18440126)1, 3 Zhang L....Pru J.K. (Mol. Cell. Endocrinol. 2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26135 HGNC: 17860 AceView: PAI-RBP1 Ensembl:ENSG00000142864 euGenes: HUgn26135
    ECgene: SERBP1 H-InvDB: SERBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SERBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SERBP1 gene:
    Search GeneIP for patents involving SERBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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