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Aliases for SERBP1 Gene

Aliases for SERBP1 Gene

  • SERPINE1 MRNA Binding Protein 1 2 3 5
  • PAI1 RNA-Binding Protein 1 3 4
  • PAI-RBP1 3 4
  • PAIRBP1 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Plasminogen Activator Inhibitor 1 RNA-Binding Protein 3
  • SERPINE1 MRNA-Binding Protein 1 4
  • PAI-1 MRNA Binding Protein 3
  • CGI-55 3
  • CHD3IP 3
  • HABP4L 3

External Ids for SERBP1 Gene

Previous GeneCards Identifiers for SERBP1 Gene

  • GC01M067590
  • GC01M067873
  • GC01M065983

Summaries for SERBP1 Gene

GeneCards Summary for SERBP1 Gene

SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer. GO annotations related to this gene include poly(A) RNA binding and mRNA 3-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot for SERBP1 Gene

  • May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Gene Wiki entry for SERBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERBP1 Gene

Genomics for SERBP1 Gene

Regulatory Elements for SERBP1 Gene

Enhancers for SERBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G067339 1.1 Ensembl ENCODE 11.2 +90.1 90105 1.8 CTCF PKNOX1 WRNIP1 ASH2L BMI1 RELA FOSL1 ZNF766 ZNF366 EED IL12RB2 SERBP1 RNU6-387P LOC105378779
GH01G067427 1.4 ENCODE dbSUPER 8.7 +0.7 658 5.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SERBP1 RNU6-387P
GH01G067399 0.9 ENCODE 13.1 +30.1 30106 1.3 PKNOX1 KLF17 ZNF2 EGR1 ZNF366 FOS SMARCA5 CAVIN1 TSHZ1 REST SERBP1 RNU4ATAC4P LOC105378779 GC01P067418
GH01G067338 0.8 ENCODE 10.8 +91.7 91748 0.8 TBP CBX5 RELB ETV6 IKZF2 ZNF362 USF2 ZEB2 GATAD2B TBX21 IL12RB2 SERBP1 RNU6-387P RNU4ATAC4P LOC105378779
GH01G067418 0.6 dbSUPER 12.6 +10.1 10088 4.1 PAF1 ZNF140 ZMYM3 PRDM6 BCL6B SCRT2 NFE2 ZNF600 EMSY RBFOX2 SERBP1 RNU6-387P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SERBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SERBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008192 1040 4401 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for SERBP1 Gene

Chromosome:
1
Start:
67,407,810 bp from pter
End:
67,430,440 bp from pter
Size:
22,631 bases
Orientation:
Minus strand

Genomic View for SERBP1 Gene

Genes around SERBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERBP1 Gene

Proteins for SERBP1 Gene

  • Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC51-PAIRB_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Protein Accession:
    Q8NC51
    Secondary Accessions:
    • Q5VU19
    • Q5VU20
    • Q5VU22
    • Q8WUH0
    • Q96SE2
    • Q9BTY3
    • Q9BUM4
    • Q9Y367
    • Q9Y4S3

    Protein attributes for SERBP1 Gene

    Size:
    408 amino acids
    Molecular mass:
    44965 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3.

    Three dimensional structures from OCA and Proteopedia for SERBP1 Gene

    Alternative splice isoforms for SERBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERBP1 Gene

Post-translational modifications for SERBP1 Gene

  • Ubiquitination at Lys52, Lys68, Lys294, and Lys320
  • Modification sites at PhosphoSitePlus

Other Protein References for SERBP1 Gene

No data available for DME Specific Peptides for SERBP1 Gene

Domains & Families for SERBP1 Gene

Protein Domains for SERBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SERBP1 Gene

Function for SERBP1 Gene

Molecular function for SERBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Gene Ontology (GO) - Molecular Function for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003730 mRNA 3-UTR binding IDA 11001948
GO:0005515 protein binding IPI 12505151
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with SERBP1: view
genes like me logo Genes that share phenotypes with SERBP1: view

Animal Model Products

miRNA for SERBP1 Gene

miRTarBase miRNAs that target SERBP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERBP1 Gene

Localization for SERBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SERBP1: view

Pathways & Interactions for SERBP1 Gene

genes like me logo Genes that share pathways with SERBP1: view

Pathways by source for SERBP1 Gene

Gene Ontology (GO) - Biological Process for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042981 regulation of apoptotic process IEA --
GO:0043488 regulation of mRNA stability NAS 11001948
genes like me logo Genes that share ontologies with SERBP1: view

No data available for SIGNOR curated interactions for SERBP1 Gene

Drugs & Compounds for SERBP1 Gene

No Compound Related Data Available

Transcripts for SERBP1 Gene

Unigene Clusters for SERBP1 Gene

SERPINE1 mRNA binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERBP1 Gene

No ASD Table

Relevant External Links for SERBP1 Gene

GeneLoc Exon Structure for
SERBP1
ECgene alternative splicing isoforms for
SERBP1

Expression for SERBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERBP1 Gene

Protein differential expression in normal tissues from HIPED for SERBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SERBP1 Gene



Protein tissue co-expression partners for SERBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SERBP1 Gene:

SERBP1

SOURCE GeneReport for Unigene cluster for SERBP1 Gene:

Hs.530412

mRNA Expression by UniProt/SwissProt for SERBP1 Gene:

Q8NC51-PAIRB_HUMAN
Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.

Evidence on tissue expression from TISSUES for SERBP1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Lung(4.8)
  • Skin(4.8)
  • Intestine(4.7)
  • Muscle(3.7)
  • Eye(3.4)
  • Kidney(3.1)
  • Pancreas(2.9)
  • Blood(2.5)
  • Bone marrow(2.2)
  • Gall bladder(2.2)
  • Heart(2.2)
  • Lymph node(2.2)
  • Spleen(2.2)
  • Stomach(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with SERBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERBP1 Gene

Orthologs for SERBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERBP1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERBP1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERBP1 34 35
  • 96.92 (n)
mouse
(Mus musculus)
Mammalia Serbp1 34 16 35
  • 93.35 (n)
oppossum
(Monodelphis domestica)
Mammalia SERBP1 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERBP1 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERBP1 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17049 34
African clawed frog
(Xenopus laevis)
Amphibia rda288-prov 34
zebrafish
(Danio rerio)
Actinopterygii serbp1a 35 35
  • 72 (a)
OneToMany
SERBP1 (3 of 3) 35
  • 66 (a)
OneToMany
Dr.383 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10597 34
fruit fly
(Drosophila melanogaster)
Insecta CG41503 35
  • 27 (a)
ManyToMany
vig 35
  • 24 (a)
ManyToMany
vig2 35
  • 23 (a)
ManyToMany
Species where no ortholog for SERBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERBP1 Gene

ENSEMBL:
Gene Tree for SERBP1 (if available)
TreeFam:
Gene Tree for SERBP1 (if available)

Paralogs for SERBP1 Gene

Paralogs for SERBP1 Gene

(2) SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERBP1: view

Variants for SERBP1 Gene

Sequence variations from dbSNP and Humsavar for SERBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000050897 -- 67,430,470(+) TGTGG(A/G)GTATG upstream-variant-2KB
rs1000096209 -- 67,430,487(+) AGAGT(C/T)ATTTC upstream-variant-2KB
rs1000116282 -- 67,414,700(+) GTCAA(A/C)AATCC intron-variant
rs1000185212 -- 67,409,425(+) CCCCC(A/C)CACAC utr-variant-3-prime
rs1000254052 -- 67,414,335(+) AAGTA(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERBP1 Gene

Variant ID Type Subtype PubMed ID
nsv1254 CNV insertion 18451855
nsv461773 CNV loss 19166990
nsv546447 CNV loss 21841781
nsv945985 CNV duplication 23825009

Variation tolerance for SERBP1 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERBP1 Gene

Disorders for SERBP1 Gene

Relevant External Links for SERBP1

Genetic Association Database (GAD)
SERBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERBP1

No disorders were found for SERBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERBP1 Gene

Publications for SERBP1 Gene

  1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton J.H. … Gelehrter T.D. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I. … Cote J. (Hum. Mol. Genet. 2008) 3 4 22 64
  3. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D. … Sehouli J. (Gynecol. Oncol. 2007) 2 3 22 64
  4. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos T.A. … Kobarg J. (FEBS Lett. 2003) 3 4 22 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64

Products for SERBP1 Gene

Sources for SERBP1 Gene

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