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Aliases for SERBP1 Gene

Aliases for SERBP1 Gene

  • SERPINE1 MRNA Binding Protein 1 2 3
  • SERPINE1 MRNA-Binding Protein 1 3 4
  • PAI1 RNA-Binding Protein 1 3 4
  • PAI-RBP1 3 4
  • PAIRBP1 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Plasminogen Activator Inhibitor 1 RNA Binding Protein 3
  • Plasminogen Activator Inhibitor 1 RNA-Binding Protein 3
  • PAI-1 MRNA Binding Protein 3
  • CGI-55 3
  • CHD3IP 3
  • HABP4L 3

External Ids for SERBP1 Gene

Summaries for SERBP1 Gene

GeneCards Summary for SERBP1 Gene

SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include mRNA 3-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot for SERBP1 Gene

  • May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay

Gene Wiki entry for SERBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERBP1 Gene

Genomics for SERBP1 Gene

Genomic Location for SERBP1 Gene

Start:
67,407,810 bp from pter
End:
67,430,440 bp from pter
Size:
22,631 bases
Orientation:
Minus strand

Genomic View for SERBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERBP1 Gene

Regulatory Elements for SERBP1 Gene

Proteins for SERBP1 Gene

  • Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC51-PAIRB_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Protein Accession:
    Q8NC51
    Secondary Accessions:
    • Q5VU19
    • Q5VU20
    • Q5VU22
    • Q8WUH0
    • Q96SE2
    • Q9BTY3
    • Q9BUM4
    • Q9Y367
    • Q9Y4S3

    Protein attributes for SERBP1 Gene

    Size:
    408 amino acids
    Molecular mass:
    44965 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3.

    Three dimensional structures from OCA and Proteopedia for SERBP1 Gene

    Alternative splice isoforms for SERBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERBP1 Gene

Proteomics data for SERBP1 Gene at MOPED

Post-translational modifications for SERBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52, Lys68, Lys122, Lys236, Lys294, and Lys320

Other Protein References for SERBP1 Gene

No data available for DME Specific Peptides for SERBP1 Gene

Domains for SERBP1 Gene

Protein Domains for SERBP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SERBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SERBP1 Gene

Function for SERBP1 Gene

Molecular function for SERBP1 Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay

Gene Ontology (GO) - Molecular Function for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 11001948
GO:0005515 protein binding IPI 12505151
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SERBP1: view

Phenotypes for SERBP1 Gene

GenomeRNAi human phenotypes for SERBP1:
genes like me logo Genes that share phenotypes with SERBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERBP1 Gene

Localization for SERBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERBP1 Gene COMPARTMENTS Subcellular localization image for SERBP1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SERBP1: view

Pathways for SERBP1 Gene

SuperPathways for SERBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042981 regulation of apoptotic process IEA --
GO:0043488 regulation of mRNA stability NAS 11001948
genes like me logo Genes that share ontologies with SERBP1: view

No data available for Pathways by source for SERBP1 Gene

Transcripts for SERBP1 Gene

Unigene Clusters for SERBP1 Gene

SERPINE1 mRNA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERBP1 Gene

No ASD Table

Relevant External Links for SERBP1 Gene

GeneLoc Exon Structure for
SERBP1
ECgene alternative splicing isoforms for
SERBP1

Expression for SERBP1 Gene

mRNA expression in normal human tissues for SERBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERBP1 Gene

SOURCE GeneReport for Unigene cluster for SERBP1 Gene Hs.530412

mRNA Expression by UniProt/SwissProt for SERBP1 Gene

Q8NC51-PAIRB_HUMAN
Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
genes like me logo Genes that share expressions with SERBP1: view

Orthologs for SERBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERBP1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERBP1 36
  • 96.92 (n)
  • 99.25 (a)
SERBP1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serbp1 36
  • 93.35 (n)
  • 98.5 (a)
Serbp1 16
Serbp1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERBP1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERBP1 37
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERBP1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 82 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rda288-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17049 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10597 36
zebrafish
(Danio rerio)
Actinopterygii Dr.383 36
SERBP1 (3 of 3) 37
  • 66 (a)
OneToMany
serbp1a 37
  • 72 (a)
OneToMany
serbp1a 37
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG41503 37
  • 27 (a)
ManyToMany
vig 37
  • 24 (a)
ManyToMany
vig2 37
  • 23 (a)
ManyToMany
Species with no ortholog for SERBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERBP1 Gene

ENSEMBL:
Gene Tree for SERBP1 (if available)
TreeFam:
Gene Tree for SERBP1 (if available)

Paralogs for SERBP1 Gene

Paralogs for SERBP1 Gene

Selected SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERBP1: view

Variants for SERBP1 Gene

Sequence variations from dbSNP and Humsavar for SERBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs969626 -- 67,413,951(+) CAGGG(A/G)TGTGC intron-variant
rs1058074 -- 67,410,801(-) AATCT(A/G)ATTGT utr-variant-3-prime
rs1060083 -- 67,408,460(-) TACCC(A/C)CACAA utr-variant-3-prime
rs1060085 -- 67,408,458(-) CCCAC(A/C)CAAGT utr-variant-3-prime
rs1948525 -- 67,407,768(-) ACAAA(A/G)AAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SERBP1 Gene

Variant ID Type Subtype PubMed ID
nsv871374 CNV Loss 21882294
nsv461773 CNV Loss 19166990
nsv1254 CNV Insertion 18451855

Relevant External Links for SERBP1 Gene

HapMap Linkage Disequilibrium report
SERBP1

Disorders for SERBP1 Gene

Relevant External Links for SERBP1

Genetic Association Database (GAD)
SERBP1
genes like me logo Genes that share disorders with SERBP1: view

No data available for UniProtKB/Swiss-Prot for SERBP1 Gene

Publications for SERBP1 Gene

  1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton J.H. … Gelehrter T.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos T.A. … Kobarg J. (FEBS Lett. 2003) 3 4 23
  3. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I. … Cote J. (Hum. Mol. Genet. 2008) 3 4 23
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  5. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D. … Sehouli J. (Gynecol. Oncol. 2007) 2 3 23

Products for SERBP1 Gene

Sources for SERBP1 Gene

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