Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERBP1 Gene

Aliases for SERBP1 Gene

  • SERPINE1 MRNA Binding Protein 1 2 3 5
  • SERPINE1 MRNA-Binding Protein 1 3 4
  • PAI1 RNA-Binding Protein 1 3 4
  • PAI-RBP1 3 4
  • PAIRBP1 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Plasminogen Activator Inhibitor 1 RNA Binding Protein 3
  • PAI-1 MRNA Binding Protein 3
  • CGI-55 3
  • CHD3IP 3
  • HABP4L 3

External Ids for SERBP1 Gene

Previous GeneCards Identifiers for SERBP1 Gene

  • GC01M067590
  • GC01M067873
  • GC01M065983

Summaries for SERBP1 Gene

GeneCards Summary for SERBP1 Gene

SERBP1 (SERPINE1 MRNA Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA 3-UTR binding. An important paralog of this gene is HABP4.

UniProtKB/Swiss-Prot for SERBP1 Gene

  • May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.

Gene Wiki entry for SERBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERBP1 Gene

Genomics for SERBP1 Gene

Regulatory Elements for SERBP1 Gene

Enhancers for SERBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SERBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SERBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SERBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SERBP1 Gene

Chromosome:
1
Start:
67,407,810 bp from pter
End:
67,430,440 bp from pter
Size:
22,631 bases
Orientation:
Minus strand

Genomic View for SERBP1 Gene

Genes around SERBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERBP1 Gene

Proteins for SERBP1 Gene

  • Protein details for SERBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC51-PAIRB_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Protein Accession:
    Q8NC51
    Secondary Accessions:
    • Q5VU19
    • Q5VU20
    • Q5VU22
    • Q8WUH0
    • Q96SE2
    • Q9BTY3
    • Q9BUM4
    • Q9Y367
    • Q9Y4S3

    Protein attributes for SERBP1 Gene

    Size:
    408 amino acids
    Molecular mass:
    44965 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3.

    Three dimensional structures from OCA and Proteopedia for SERBP1 Gene

    Alternative splice isoforms for SERBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERBP1 Gene

Proteomics data for SERBP1 Gene at MOPED

Post-translational modifications for SERBP1 Gene

  • Ubiquitination at Lys 52, Lys 68, Lys 294, and Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for SERBP1 Gene

No data available for DME Specific Peptides for SERBP1 Gene

Domains & Families for SERBP1 Gene

Protein Domains for SERBP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SERBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SERBP1 Gene

Function for SERBP1 Gene

Molecular function for SERBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of mRNA stability. Binds to the 3-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
genes like me logo Genes that share phenotypes with SERBP1: view

Animal Model Products

miRNA for SERBP1 Gene

miRTarBase miRNAs that target SERBP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SERBP1 Gene

Localization for SERBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERBP1 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERBP1 Gene COMPARTMENTS Subcellular localization image for SERBP1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SERBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SERBP1: view

Pathways & Interactions for SERBP1 Gene

SuperPathways for SERBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SERBP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SERBP1 Gene

Drugs & Compounds for SERBP1 Gene

No Compound Related Data Available

Transcripts for SERBP1 Gene

Unigene Clusters for SERBP1 Gene

SERPINE1 mRNA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERBP1 Gene

No ASD Table

Relevant External Links for SERBP1 Gene

GeneLoc Exon Structure for
SERBP1
ECgene alternative splicing isoforms for
SERBP1

Expression for SERBP1 Gene

mRNA expression in normal human tissues for SERBP1 Gene

Protein differential expression in normal tissues from HIPED for SERBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERBP1 Gene



SOURCE GeneReport for Unigene cluster for SERBP1 Gene Hs.530412

mRNA Expression by UniProt/SwissProt for SERBP1 Gene

Q8NC51-PAIRB_HUMAN
Tissue specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
genes like me logo Genes that share expression patterns with SERBP1: view

Protein tissue co-expression partners for SERBP1 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SERBP1 Gene

Orthologs for SERBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERBP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SERBP1 35
  • 96.92 (n)
  • 99.25 (a)
SERBP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serbp1 35
  • 93.35 (n)
  • 98.5 (a)
Serbp1 16
Serbp1 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERBP1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERBP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERBP1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERBP1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERBP1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17049 35
African clawed frog
(Xenopus laevis)
Amphibia rda288-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.383 35
SERBP1 (3 of 3) 36
  • 66 (a)
OneToMany
serbp1a 36
  • 72 (a)
OneToMany
serbp1a 36
  • 72 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10597 35
fruit fly
(Drosophila melanogaster)
Insecta CG41503 36
  • 27 (a)
ManyToMany
vig 36
  • 24 (a)
ManyToMany
vig2 36
  • 23 (a)
ManyToMany
Species with no ortholog for SERBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERBP1 Gene

ENSEMBL:
Gene Tree for SERBP1 (if available)
TreeFam:
Gene Tree for SERBP1 (if available)

Paralogs for SERBP1 Gene

Paralogs for SERBP1 Gene

(2) SIMAP similar genes for SERBP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SERBP1: view

Variants for SERBP1 Gene

Sequence variations from dbSNP and Humsavar for SERBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs969626 -- 67,413,951(+) CAGGG(A/G)TGTGC intron-variant
rs1058074 -- 67,410,801(-) AATCT(A/G)ATTGT utr-variant-3-prime
rs1060083 -- 67,408,460(-) TACCC(A/C)CACAA utr-variant-3-prime
rs1060085 -- 67,408,458(-) CCCAC(A/C)CAAGT utr-variant-3-prime
rs1948525 -- 67,407,768(-) ACAAA(A/G)AAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SERBP1 Gene

Variant ID Type Subtype PubMed ID
nsv871374 CNV Loss 21882294
nsv461773 CNV Loss 19166990
nsv1254 CNV Insertion 18451855

Variation tolerance for SERBP1 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SERBP1 Gene

Disorders for SERBP1 Gene

Relevant External Links for SERBP1

Genetic Association Database (GAD)
SERBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERBP1

No disorders were found for SERBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SERBP1 Gene

Publications for SERBP1 Gene

  1. Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA. (PMID: 11001948) Heaton J.H. … Gelehrter T.D. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. (PMID: 17698176) Koensgen D. … Sehouli J. (Gynecol. Oncol. 2007) 2 3 23
  3. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. (PMID: 18440126) Zhang L. … Pru J.K. (Mol. Cell. Endocrinol. 2008) 2 3
  4. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I. … Cote J. (Hum. Mol. Genet. 2008) 3 23
  5. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos T.A. … Kobarg J. (FEBS Lett. 2003) 3 23

Products for SERBP1 Gene

Sources for SERBP1 Gene

Content