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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SERAC1 Gene

protein-coding   GIFtS: 48
GCID: GC06M158500

Serine Active Site Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Active Site Containing 11 2
Serine Active Site-Containing Protein 12 3
Protein SERAC12

External Ids:    HGNC: 210611   Entrez Gene: 849472   Ensembl: ENSG000001223357   OMIM: 6147255   UniProtKB: Q96JX33   

Export aliases for SERAC1 gene to outside databases

Previous GC identifers: GC06M158363 GC06M158439 GC06M156002


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SERAC1 Gene:
The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of
mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major
role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript
variants, one protein-coding and the other non-protein coding, have been found for this gene. (provided by
RefSeq, Aug 2012)

GeneCards Summary for SERAC1 Gene: 
SERAC1 (serine active site containing 1) is a protein-coding gene. Diseases associated with SERAC1 include leigh-like syndrome, and 3-methylglutaconic aciduria. GO annotations related to this gene include hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot: SRAC1_HUMAN, Q96JX3
Function: Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial
function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be
involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in
bis(monoacylglycerol)phosphate biosynthetic pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SERAC1 gene promoter:
         USF1   Sp1   Pax-5   SREBP-1c   USF2   USF-1:USF-2   SREBP-1b   AREB6   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSERAC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SERAC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SERAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SERAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SERAC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M158500:  view genomic region     (about GC identifiers)

Start:
158,530,536 bp from pter      End:
158,589,312 bp from pter
Size:
58,777 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRAC1_HUMAN, Q96JX3 (See protein sequence)
Recommended Name: Protein SERAC1  
Size: 654 amino acids; 74147 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum. Mitochondrion.
Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface
Secondary accessions: Q49AT1 Q5VTX3 Q6PKF3
Alternative splicing: 3 isoforms:  Q96JX3-1   Q96JX3-2   Q96JX3-3   

Explore the universe of human proteins at neXtProt for SERAC1: NX_Q96JX3

Explore proteomics data for SERAC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JX3

  • SERAC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SERAC1 Protein Expression
    REFSEQ proteins: NP_116250.3  
    ENSEMBL proteins: 
     ENSP00000356071   ENSP00000475523   ENSP00000475855   ENSP00000475808   ENSP00000391168  
     ENSP00000356068   ENSP00000475788   ENSP00000356069  

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    Cloud-Clone Corp. Proteins for SERAC1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral to membrane IEA--
    GO:0031012extracellular matrix IEA--

    SERAC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR012908 PGAP1-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96JX3

    ProtoNet protein and cluster: Q96JX3

    UniProtKB/Swiss-Prot: SRAC1_HUMAN, Q96JX3
    Similarity: Belongs to the SERAC1 family


    SERAC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRAC1_HUMAN, Q96JX3
    Function: Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial
    function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be
    involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in
    bis(monoacylglycerol)phosphate biosynthetic pathway

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0016788hydrolase activity, acting on ester bonds IEA--
         
    SERAC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SERAC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SERAC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SERAC1 
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SERAC1 (see all 11):
    hsa-miR-21* hsa-miR-1283 hsa-miR-578 hsa-miR-7 hsa-miR-570 hsa-miR-1912 hsa-miR-646 hsa-miR-27b*
    SwitchGear 3'UTR luciferase reporter plasmidSERAC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SERAC1

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006505GPI anchor metabolic process IEA--
    GO:0006886intracellular protein transport IEA--
    GO:0008654phospholipid biosynthetic process IEA--
    GO:0030198extracellular matrix organization IEA--

    SERAC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SERAC1 (SRAC1)

    Search CenterWatch for drugs/clinical trials and news about SERAC1 / SRAC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SERAC1 gene: 
    NM_032861.3  

    Unigene Cluster for SERAC1:

    Serine active site containing 1
    Hs.154706  [show with all ESTs]
    Unigene Representative Sequence: BX648104
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367104 ENST00000607742 ENST00000607071 ENST00000606965 ENST00000435180
    ENST00000367101 ENST00000607000 ENST00000367102(uc003qrb.2 uc003qrc.2)

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SERAC1 (see all 11):
    hsa-miR-21* hsa-miR-1283 hsa-miR-578 hsa-miR-7 hsa-miR-570 hsa-miR-1912 hsa-miR-646 hsa-miR-27b*
    SwitchGear 3'UTR luciferase reporter plasmidSERAC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: SERAC1 (NM_032861)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SERAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SERAC1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SERAC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SERAC1

    Additional mRNA sequence: 

    AK023656.1 AK027823.1 AK125878.1 BC001705.1 BC028594.1 BC048335.1 BC060795.1 BX648104.1 
    NR_073096.1 

    8 DOTS entries:

    DT.308033  DT.101982623  DT.91701114  DT.100751272  DT.75120946  DT.121346976  DT.205459  DT.95268400 

    24/63 AceView cDNA sequences (see all 63):

    NM_032861 AW236925 AI140856 BU157257 BQ002844 BC048335 BC001705 BG007378 
    AA598967 BQ182984 AK027823 BM129353 CK904864 AI128567 F00318 BX648104 
    BM129791 AI039171 BI118077 AA148416 BC028594 AK125878 AI935591 CK904863 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SERAC1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:              -     -                                                                                                           -               
    SP2:              -     -           -                                                                                               -               
    SP3:                                                                                            -                                                   
    SP4:                                                                          -                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for SERAC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SERAC1 expression in normal human tissues (normalized intensities)      SERAC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCATTTGTG
    SERAC1 Expression
    About this image


    SERAC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocyte-derived macrophage   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             TONGUE   

    See SERAC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SERAC1

    SOURCE GeneReport for Unigene cluster: Hs.154706

    UniProtKB/Swiss-Prot: SRAC1_HUMAN, Q96JX3
    Tissue specificity: Widely expressed, with predominant expression in fetal skeletal muscle and adult brain. In the
    brain, highest levels are found in the frontal and occipital cortices, cerebellum and hippocampus

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SERAC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SERAC1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Serac11 , 5 serine active site containing 11, 5 84.51(n)1
    86.85(a)1
      17 (3.67 cM)5
    3210071  NM_001111017.11  NP_001104487.11 
     60421965 
    chicken
    (Gallus gallus)
    Aves SERAC11 serine active site containing 1 73.26(n)
    70.86(a)
      421657  XM_419696.3  XP_419696.3 
    lizard
    (Anolis carolinensis)
    Reptilia SERAC16
    serine active site containing 1
    67(a)
    1 ↔ 1
    1(212977953-213014569)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.131792 Danio rerio cDNA clone IMAGE5602171, partial cds 72.47(n)    BC054925.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103831 CG10383 45.84(n)
    35.7(a)
      35123  NM_136052.2  NP_609896.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F17H10.16
    Protein F17H10.1
    22(a)
    1 ↔ 1
    X(13105192-13108543)
    rice
    (Oryza sativa)
    Liliopsida Os03g01855001 hypothetical protein 49.67(n)
    41.5(a)
      4331865  NM_001055732.1  NP_001049197.1 


    ENSEMBL Gene Tree for SERAC1 (if available)
    TreeFam Gene Tree for SERAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1260 SNPs in SERAC1 are shown (see all 1260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0684424
    3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)4--see VAR_0684422 G D mis40--------
    VAR_0684434
    3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)4--see VAR_0684432 G E mis40--------
    rs2019414761,2,4
    3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)4 --158537225(+) CCATGC/GTATGT 3 T S mis10--------
    rs93658861,2
    C,F,H--158530037(+) CAGTTG/TTTTCA 1 -- ds500117Minor allele frequency- T:0.27NS EA NA WA 2336
    rs1931662151,2
    --158530063(+) CCATGG/TTTCAC 1 -- ds50010--------
    rs93470771,2
    C--158530104(+) GGGCCA/GGGTGT 1 -- ds50013Minor allele frequency- G:0.31NA EA 242
    rs69371271,2
    C,F,A,H--158530106(+) GCCAGT/GTGTGG 1 -- ds50017Minor allele frequency- G:0.47WA NA CSA EA 250
    rs1124378971,2
    C,F--158530123(+) ACGCCC/TGTAAT 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1421156311,2
    C--158530152(+) CGAGGC/TGGGCA 1 -- ds50010--------
    rs1511682281,2
    --158530190(+) TCCTGA/GCCAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SERAC1 (158530536 - 158589312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SERAC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2527722CNV Deletion19546169
    esv5299CNV Deletion18987735
    esv1769243CNV Deletion17803354
    esv1916968CNV Deletion18987734
    esv2732993CNV Deletion23290073
    esv8377CNV Loss19470904
    nsv511920CNV Loss21212237
    nsv348752CNV Loss16902084
    nsv830849CNV Loss17160897
    nsv886797CNV Gain21882294


    Human Gene Mutation Database (HGMD): SERAC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SERAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SERAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614725    OMIM disorders: --

    UniProtKB/Swiss-Prot: SRAC1_HUMAN, Q96JX3
  • 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL) [MIM:614739]:
    An autosomal recessive disorder characterized by childhood onset of delayed psychomotor development or
    psychomotor regression, sensorineural deafness, spasticity or dystonia, and increased excretion of
    3-methylglutaconic acid. Brain imaging shows cerebral and cerebellar atrophy as well as lesions in the basal
    ganglia reminiscent of Leigh syndrome. Laboratory studies show increased serum lactate and alanine, mitochondrial
    oxidative phosphorylation defects, abnormal mitochondria, abnormal phosphatidylglycerol and cardiolipin profiles
    in fibroblasts, and abnormal accumulation of unesterified cholesterol within cells. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for SERAC1:    About MalaCards
    leigh-like syndrome    3-methylglutaconic aciduria    spasticity    cerebritis


    SERAC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SERAC1
    Human Genome Epidemiology (HuGE) Navigator: SERAC1 (1 document)

    Export disorders for SERAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SERAC1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SERAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the phospholipid remodeling gene SERAC1 i mpair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. (PubMed id 22683713)1, 2 Wortmann S.B....de Brouwer A.P. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Exome sequencing identifies a new mutation in SERAC1 in a patient with 3-methylglutaconic aciduria. (PubMed id 23707711)2 Tort F.... Ribes A. (2013)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Autoantibodies to tailor-made panels of tumor-associat ed antigens in breast carcinoma. (PubMed id 21423545)1 Piura E. and Piura B. (2011)
    9. Detection of alpha-rod protein repeats using a neural network and application to huntingtin. (PubMed id 19282972)1 Palidwor G.A....Andrade-Navarro M.A. (2009)
    10. Association of 3-methylglutaconic aciduria with sensori-neural deafness, encephalopathy, and Leigh-like syndrome (MEGDEL association) in four patients with a disorder of the oxidative phosphorylation. (PubMed id 16527507)1 Wortmann S....Morava E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84947 HGNC: 21061 AceView: SERAC1 Ensembl:ENSG00000122335 euGenes: HUgn84947
    ECgene: SERAC1 H-InvDB: SERAC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SERAC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SERAC1 gene:
    Search GeneIP for patents involving SERAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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