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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPW1 Gene

protein-coding   GIFtS: 50
GCID: GC19P048281

selenoprotein W, 1

 Explore 10 diseases affiliated with
SEPW1 via our new
 Human Malady Compendium 
Biological research products
for SEPW1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Selenoprotein W, 11 2
SelW3
Selenoprotein W2
SELW3
SelW3

External Ids:    HGNC: 107521   Entrez Gene: 64152   Ensembl: ENSG000001789807   OMIM: 6032355   UniProtKB: P633023   
ORGUL members:         
NONCODE:n342407    

Export aliases for SEPW1 gene to outside databases

Previous GC identifers: GC19P048928 GC19P048672 GC19P052957 GC19P052973 GC19P044708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPW1:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine
is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a
common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec
codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be
involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to
chromosome 1p35-34. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SELW_HUMAN, P63302
Function: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May
play a role in the myopathies of selenium deficiency (By similarity)

Gene Wiki entry for SEPW1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPW1 gene promoter:
         NF-1   NCX/Ncx   Olf-1   Egr-4   GATA-1   MZF-1   Egr-2   E2F-1   E2F   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEPW1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEPW1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPW1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

SEPW1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPW1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048281:  view genomic region     (about GC identifiers)

Start:
48,281,842 bp from pter      End:
48,287,941 bp from pter
Size:
6,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SELW_HUMAN, P63302 (See protein sequence)
Recommended Name: Selenoprotein W  
Size: 87 amino acids; 9448 Da
Subunit: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90 (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: A8MRR7 O15532 O19096 Q86TI9 Q96KM5

Explore the universe of human proteins at neXtProt for SEPW1: NX_P63302

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P63302

  • SEPW1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003000.1  
    ENSEMBL proteins: 
     ENSP00000422644  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SEPW1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--


    SEPW1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEPW1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011893 Selenoprotein_Rdx-typ
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry P63302

    ProtoNet protein and cluster: P63302

    UniProtKB/Swiss-Prot: SELW_HUMAN, P63302
    Similarity: Belongs to the SelWTH family. SELW subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SELW_HUMAN, P63302
    Function: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May
    play a role in the myopathies of selenium deficiency (By similarity)

    miRNA
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    hsa-miR-185* hsa-miR-1910 hsa-miR-455-3p hsa-miR-3667-3p
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPW1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008430selenium binding IEA--
    GO:0016209antioxidant activity IEA--


    SEPW1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SEPW1:
     Large nuclei 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins1.00
    2Selenium Pathway
    Selenium Pathway1.00


    2 BioSystems Pathways for SEPW1 
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPW1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--


    SEPW1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPW1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEPW1

    2 HMDB Compounds for SEPW1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--
    4 Novoseek chemical compound relationships for SEPW1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenophosphate 86.8 2 15634611 (1), 18790070 (1)
    selenocysteine 86.4 3 10333732 (1), 10718624 (1)
    selenium 80.8 12 19387567 (2), 11842884 (1), 10718624 (1), 12807419 (1) (see all 6)
    cysteine 23.2 3 9882425 (1), 10718624 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPW1 / SELW 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEPW1 gene: 
    NM_003009.2  

    Unigene Cluster for SEPW1:

    Selenoprotein W, 1
    Hs.631549  [show with all ESTs]
    Unigene Representative Sequence: BF341549
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000509570(uc021uwp.1)

    miRNA
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    hsa-miR-185* hsa-miR-1910 hsa-miR-455-3p hsa-miR-3667-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF015283.1 BC000581.2 BC032546.1 BC039597.1 BC047893.1 U67171.1 

    21 DOTS entries:

    DT.454305  DT.101985189  DT.40122367  DT.100843999  DT.91749466  DT.121417151  DT.100709603  DT.121417103 
    DT.95088651  DT.121417017  DT.121417159  DT.97855726  DT.100689006  DT.100843997  DT.100844000  DT.100844005 
    DT.121403432  DT.92470119  DT.92470121  DT.95270315  DT.97855723 

    24/757 AceView cDNA sequences (see all 757):

    AA378617 BU849498 AA354900 BC047893 CD243073 AI143021 BM715297 BQ670400 
    BQ651187 BQ015366 BQ681340 BQ669436 BF058918 BQ007590 BE294378 CB266077 
    BU184423 BU552903 CD676366 AI241659 BQ631204 AA316704 BU194755 CR617899 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SEPW1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:        -     -           -                 -     -                           
    SP2:              -           -                 -     -                           
    SP3:              -                                                               
    SP4:                          -                 -     -     -                     
    SP5:                                            -     -                           


    ECgene alternative splicing isoforms for SEPW1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPW1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTCCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEPW1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPW1

    SOURCE GeneReport for Unigene cluster: Hs.631549

    UniProtKB/Swiss-Prot: SELW_HUMAN, P63302
    Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain,
    spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEPW1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sepw11 , 5 selenoprotein W, muscle 11, 5 87.21(n)1
    88.37(a)1
      7 (8.62 cM)5
    203641  NM_009156.21  NP_033182.11 
     159172085 
    chicken
    (Gallus gallus)
    Aves SEPW11 selenoprotein W, 1 65.48(n)
    58.33(a)
      100310814  NM_001166327.1  NP_001159799.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPW16
    --
    64(a)
    1 ↔ 1
    GL343403.1(400202-400423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.762 Transcribed sequence with weak similarity to protein more 74.02(n)    142027556 
    zebrafish
    (Danio rerio)
    Actinopterygii AY216582.12   -- 71.07(n)   352915  AY216582.1 


    ENSEMBL Gene Tree for SEPW1 (if available)
    TreeFam Gene Tree for SEPW1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEPW1 gene
    SELV2  
    2 SIMAP similar genes for SEPW1 using alignment to 3 protein entries:     SELW_HUMAN (see all proteins):
    SELV    MIEN1

    SEPW1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEPW1
    PGOHUM00000243954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPW1
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPW1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEPW1 for disorders           About GeneDecksing

    OMIM gene information: 603235    OMIM disorders: --

    10 diseases for SEPW1:    About MalaCards
    temporal lobe epilepsy    keshan disease    multiple myeloma    brain disease
    myeloma    myopathy    breast cancer    thyroiditis
    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SEPW1:
    Keshan disease

    1 Novoseek disease relationship for SEPW1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 73 1 11842884 (1)


    Export disorders for SEPW1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPW1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SEPW1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. (PubMed id 9256076)1, 2, 3 Gu Q.-P....Whanger P.D. (1997)
    2. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. (PubMed id 12818432)1, 2, 9 Bellingham J.... Gregory-Evans C.Y. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Selenoprotein W modulates control of cell cycle entry . (PubMed id 19387567)1, 9 Hawkes W.C....Dawson K. (2009)
    5. Selenoprotein W accumulates primarily in primate skeletal muscle, heart, brain and tongue. (PubMed id 10718624)2, 9 Gu Q.P....Whanger P.D. (2000)
    6. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. (PubMed id 15823556)1, 9 Kim Y.J....Ryu J.C. (2005)
    7. Selenoprotein W: a review. (PubMed id 11215511)1, 9 Whanger P.D. (2000)
    8. Selenoprotein W depletion induces a p53- and p21-depen dent delay in cell cycle progression in RWPE-1 prostate epithelial cells. (PubMed id 21866568)1 Hawkes W.C....Alkan Z. (2012)
    9. Delayed cell cycle progression in selenoprotein W-depl eted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway. (PubMed id 22730327)1 Hawkes W.C. and Alkan Z. (2012)
    10. Delayed cell cycle progression from SEPW1 depletion i s p53- and p21-dependent in MCF-7 breast cancer cells. (PubMed id 21875573)1 Hawkes W.C. and Alkan Z. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6415 HGNC: 10752 AceView: SEPW1 Ensembl:ENSG00000178980 euGenes: HUgn6415
    ECgene: SEPW1 H-InvDB: SEPW1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPW1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEPW1 gene:
    Search GeneIP for patents involving SEPW1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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