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Aliases for SEPW1 Gene

Aliases for SEPW1 Gene

  • Selenoprotein W, 1 2 3
  • SelW 3 4
  • Selenoprotein W 3

External Ids for SEPW1 Gene

Previous GeneCards Identifiers for SEPW1 Gene

  • GC19P048928
  • GC19P048672
  • GC19P052957
  • GC19P052973
  • GC19P048281
  • GC19P044708

Summaries for SEPW1 Gene

Entrez Gene Summary for SEPW1 Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEPW1 Gene

SEPW1 (Selenoprotein W, 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include antioxidant activity and selenium binding. An important paralog of this gene is SELV.

UniProtKB/Swiss-Prot for SEPW1 Gene

  • Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Wiki entry for SEPW1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPW1 Gene

Genomics for SEPW1 Gene

Regulatory Elements for SEPW1 Gene

Genomic Location for SEPW1 Gene

Start:
47,778,572 bp from pter
End:
47,784,686 bp from pter
Size:
6,115 bases
Orientation:
Plus strand

Genomic View for SEPW1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPW1 Gene

Proteins for SEPW1 Gene

  • Protein details for SEPW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63302-SELW_HUMAN
    Recommended name:
    Selenoprotein W
    Protein Accession:
    P63302
    Secondary Accessions:
    • A8MRR7
    • O15532
    • O19096
    • Q86TI9
    • Q96KM5

    Protein attributes for SEPW1 Gene

    Size:
    87 amino acids
    Molecular mass:
    9448 Da
    Quaternary structure:
    • Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.

neXtProt entry for SEPW1 Gene

Proteomics data for SEPW1 Gene at MOPED

Post-translational modifications for SEPW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEPW1 Gene

No data available for DME Specific Peptides for SEPW1 Gene

Domains for SEPW1 Gene

Protein Domains for SEPW1 Gene

Suggested Antigen Peptide Sequences for SEPW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63302

UniProtKB/Swiss-Prot:

SELW_HUMAN :
  • P63302
Family:
  • Belongs to the SelWTH family. SELW subfamily.
genes like me logo Genes that share domains with SEPW1: view

No data available for Gene Families for SEPW1 Gene

Function for SEPW1 Gene

Molecular function for SEPW1 Gene

UniProtKB/Swiss-Prot Function: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Ontology (GO) - Molecular Function for SEPW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IEA --
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with SEPW1: view

Phenotypes for SEPW1 Gene

GenomeRNAi human phenotypes for SEPW1:
genes like me logo Genes that share phenotypes with SEPW1: view

miRNA for SEPW1 Gene

miRTarBase miRNAs that target SEPW1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEPW1 Gene

Localization for SEPW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPW1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPW1 Gene COMPARTMENTS Subcellular localization image for SEPW1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SEPW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SEPW1: view

Pathways for SEPW1 Gene

genes like me logo Genes that share pathways with SEPW1: view

Pathways by source for SEPW1 Gene

2 BioSystems pathways for SEPW1 Gene

Interacting Proteins for SEPW1 Gene

Gene Ontology (GO) - Biological Process for SEPW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with SEPW1: view

Compounds for SEPW1 Gene

(2) HMDB Compounds for SEPW1 Gene

Compound Synonyms Cas Number PubMed IDs
Selenium
  • selenium
7782-49-2
Selenocysteine
  • (2R)-2-amino-3-selanylpropanoate
3614-08-2

(4) Novoseek inferred chemical compound relationships for SEPW1 Gene

Compound -log(P) Hits PubMed IDs
selenophosphate 86.8 2
selenocysteine 86.4 2
selenium 80.8 7
cysteine 23.2 2
genes like me logo Genes that share compounds with SEPW1: view

Transcripts for SEPW1 Gene

Unigene Clusters for SEPW1 Gene

Selenoprotein W, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPW1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8:

Relevant External Links for SEPW1 Gene

GeneLoc Exon Structure for
SEPW1
ECgene alternative splicing isoforms for
SEPW1

Expression for SEPW1 Gene

mRNA expression in normal human tissues for SEPW1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SEPW1 Gene

SOURCE GeneReport for Unigene cluster for SEPW1 Gene Hs.631549

mRNA Expression by UniProt/SwissProt for SEPW1 Gene

P63302-SELW_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.
genes like me logo Genes that share expressions with SEPW1: view

No data available for mRNA differential expression in normal tissues for SEPW1 Gene

Orthologs for SEPW1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPW1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPW1 35
  • 100 (n)
  • 100 (a)
SEPW1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEPW1 35
  • 90.04 (n)
  • 89.61 (a)
SEPW1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPW1 35
  • 91.57 (n)
  • 93.1 (a)
SEPW1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sepw1 35
  • 87.21 (n)
  • 88.37 (a)
Sepw1 16
Sepw1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPW1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPW1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sepw1 35
  • 88.76 (n)
  • 88.37 (a)
chicken
(Gallus gallus)
Aves SEPW1 35
  • 65.48 (n)
  • 58.33 (a)
lizard
(Anolis carolinensis)
Reptilia SEPW1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.76 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sepw1 35
  • 64.73 (n)
  • 58.14 (a)
sepw1 36
  • 57 (a)
OneToMany
Species with no ortholog for SEPW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPW1 Gene

ENSEMBL:
Gene Tree for SEPW1 (if available)
TreeFam:
Gene Tree for SEPW1 (if available)

Paralogs for SEPW1 Gene

Paralogs for SEPW1 Gene

Selected SIMAP similar genes for SEPW1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SEPW1 Gene

genes like me logo Genes that share paralogs with SEPW1: view

Variants for SEPW1 Gene

Sequence variations from dbSNP and Humsavar for SEPW1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14638 -- 47,784,667(+) TAAAT(A/T)TTGGA utr-variant-3-prime
rs965968 -- 47,782,436(+) GCCCC(C/G)CTTCC intron-variant
rs1046750 -- 47,784,472(+) ATCCA(A/C)ACCAC utr-variant-3-prime
rs1047219 -- 47,784,600(+) GCCAA(A/G)AGAGG utr-variant-3-prime
rs1047244 -- 47,784,602(+) CAAGA(A/G)AGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEPW1 Gene

Variant ID Type Subtype PubMed ID
dgv3964n71 CNV Loss 21882294
nsv912210 CNV Gain 21882294
nsv912211 CNV Loss 21882294
nsv912212 CNV Gain 21882294
nsv482046 CNV Loss 20164927
nsv520073 CNV Gain 19592680

Relevant External Links for SEPW1 Gene

HapMap Linkage Disequilibrium report
SEPW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPW1 Gene

Disorders for SEPW1 Gene

(1) Novoseek inferred disease relationships for SEPW1 Gene

Disease -log(P) Hits PubMed IDs
selenium deficiency 73 1
genes like me logo Genes that share disorders with SEPW1: view

No data available for UniProtKB/Swiss-Prot for SEPW1 Gene

Publications for SEPW1 Gene

  1. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. (PMID: 12818432) Bellingham J. … Gregory-Evans C.Y. (Biochim. Biophys. Acta 2003) 3 4 23
  2. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. (PMID: 9256076) Gu Q.-P. … Whanger P.D. (Gene 1997) 2 3 4
  3. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. (PMID: 15823556) Kim Y.J. … Ryu J.C. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Selenoprotein W accumulates primarily in primate skeletal muscle, heart, brain and tongue. (PMID: 10718624) Gu Q.P. … Whanger P.D. (Mol. Cell. Biochem. 2000) 4 23

Products for SEPW1 Gene

Sources for SEPW1 Gene

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