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Aliases for SEPW1 Gene

Aliases for SEPW1 Gene

  • Selenoprotein W, 1 2 3 5
  • SelW 3 4

External Ids for SEPW1 Gene

Previous GeneCards Identifiers for SEPW1 Gene

  • GC19P048928
  • GC19P048672
  • GC19P052957
  • GC19P052973
  • GC19P048281
  • GC19P044708

Summaries for SEPW1 Gene

Entrez Gene Summary for SEPW1 Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEPW1 Gene

SEPW1 (Selenoprotein W, 1) is a Protein Coding gene. Among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include antioxidant activity and selenium binding. An important paralog of this gene is SELV.

UniProtKB/Swiss-Prot for SEPW1 Gene

  • Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Wiki entry for SEPW1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPW1 Gene

Genomics for SEPW1 Gene

Regulatory Elements for SEPW1 Gene

Promoters for SEPW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEPW1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEPW1 Gene

Chromosome:
19
Start:
47,778,572 bp from pter
End:
47,784,686 bp from pter
Size:
6,115 bases
Orientation:
Plus strand

Genomic View for SEPW1 Gene

Genes around SEPW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPW1 Gene

Proteins for SEPW1 Gene

  • Protein details for SEPW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63302-SELW_HUMAN
    Recommended name:
    Selenoprotein W
    Protein Accession:
    P63302
    Secondary Accessions:
    • A8MRR7
    • O15532
    • O19096
    • Q86TI9
    • Q96KM5

    Protein attributes for SEPW1 Gene

    Size:
    87 amino acids
    Molecular mass:
    9448 Da
    Quaternary structure:
    • Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.

neXtProt entry for SEPW1 Gene

Proteomics data for SEPW1 Gene at MOPED

Post-translational modifications for SEPW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEPW1 Gene

No data available for DME Specific Peptides for SEPW1 Gene

Domains & Families for SEPW1 Gene

Protein Domains for SEPW1 Gene

Suggested Antigen Peptide Sequences for SEPW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63302

UniProtKB/Swiss-Prot:

SELW_HUMAN :
  • Belongs to the SelWTH family. SELW subfamily.
Family:
  • Belongs to the SelWTH family. SELW subfamily.
genes like me logo Genes that share domains with SEPW1: view

No data available for Gene Families for SEPW1 Gene

Function for SEPW1 Gene

Molecular function for SEPW1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Phenotypes for SEPW1 Gene

MGI mutant phenotypes for SEPW1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SEPW1:
genes like me logo Genes that share phenotypes with SEPW1: view

Animal Models for SEPW1 Gene

MGI Knock Outs for SEPW1:

Animal Model Products

miRNA for SEPW1 Gene

miRTarBase miRNAs that target SEPW1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEPW1 Gene

Localization for SEPW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPW1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPW1 Gene COMPARTMENTS Subcellular localization image for SEPW1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SEPW1 Gene

Pathways & Interactions for SEPW1 Gene

genes like me logo Genes that share pathways with SEPW1: view

Pathways by source for SEPW1 Gene

2 BioSystems pathways for SEPW1 Gene

Interacting Proteins for SEPW1 Gene

Gene Ontology (GO) - Biological Process for SEPW1 Gene

None

No data available for SIGNOR curated interactions for SEPW1 Gene

Drugs & Compounds for SEPW1 Gene

(3) Drugs for SEPW1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 166

(1) Additional Compounds for SEPW1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SEPW1: view

Transcripts for SEPW1 Gene

Unigene Clusters for SEPW1 Gene

Selenoprotein W, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPW1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8:

Relevant External Links for SEPW1 Gene

GeneLoc Exon Structure for
SEPW1
ECgene alternative splicing isoforms for
SEPW1

Expression for SEPW1 Gene

mRNA expression in normal human tissues for SEPW1 Gene

Protein differential expression in normal tissues from HIPED for SEPW1 Gene

This gene is overexpressed in Uterus (12.8), Fetal Brain (12.3), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEPW1 Gene



SOURCE GeneReport for Unigene cluster for SEPW1 Gene Hs.631549

mRNA Expression by UniProt/SwissProt for SEPW1 Gene

P63302-SELW_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.
genes like me logo Genes that share expression patterns with SEPW1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SEPW1 Gene

Orthologs for SEPW1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPW1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEPW1 35
  • 90.04 (n)
  • 89.61 (a)
SEPW1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPW1 35
  • 91.57 (n)
  • 93.1 (a)
SEPW1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sepw1 35
  • 87.21 (n)
  • 88.37 (a)
Sepw1 16
Sepw1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEPW1 35
  • 100 (n)
  • 100 (a)
SEPW1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sepw1 35
  • 88.76 (n)
  • 88.37 (a)
oppossum
(Monodelphis domestica)
Mammalia SEPW1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPW1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPW1 35
  • 65.48 (n)
  • 58.33 (a)
lizard
(Anolis carolinensis)
Reptilia SEPW1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.76 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sepw1 35
  • 64.73 (n)
  • 58.14 (a)
sepw1 36
  • 57 (a)
OneToMany
Species with no ortholog for SEPW1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPW1 Gene

ENSEMBL:
Gene Tree for SEPW1 (if available)
TreeFam:
Gene Tree for SEPW1 (if available)

Paralogs for SEPW1 Gene

Paralogs for SEPW1 Gene

(2) SIMAP similar genes for SEPW1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SEPW1 Gene

genes like me logo Genes that share paralogs with SEPW1: view

Variants for SEPW1 Gene

Sequence variations from dbSNP and Humsavar for SEPW1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs14638 -- 47,784,667(+) TAAAT(A/T)TTGGA utr-variant-3-prime
rs1063126 -- 47,784,569(+) ATCCC(A/C/G)CCTCA utr-variant-3-prime
rs1804933 -- 47,784,423(+) GGTCT(A/T)TGCCT utr-variant-3-prime
rs965968 -- 47,782,436(+) GCCCC(C/G)CTTCC intron-variant
rs2042285 -- 47,784,683(+) TTAAC(C/T)GAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SEPW1 Gene

Variant ID Type Subtype PubMed ID
dgv3964n71 CNV Loss 21882294
nsv912210 CNV Gain 21882294
nsv912211 CNV Loss 21882294
nsv912212 CNV Gain 21882294
nsv482046 CNV Loss 20164927
nsv520073 CNV Gain 19592680

Variation tolerance for SEPW1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPW1 Gene

HapMap Linkage Disequilibrium report
SEPW1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPW1 Gene

Disorders for SEPW1 Gene

Relevant External Links for SEPW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEPW1

No disorders were found for SEPW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPW1 Gene

Publications for SEPW1 Gene

  1. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. (PMID: 9256076) Gu Q.-P. … Whanger P.D. (Gene 1997) 2 3 4 67
  2. Selenoprotein W modulates control of cell cycle entry. (PMID: 19387567) Hawkes W.C. … Dawson K. (Biol Trace Elem Res 2009) 3 23
  3. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. (PMID: 15823556) Kim Y.J. … Ryu J.C. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. (PMID: 12818432) Bellingham J. … Gregory-Evans C.Y. (Biochim. Biophys. Acta 2003) 3 23
  5. Selenoprotein W: a review. (PMID: 11215511) Whanger P.D. (Cell. Mol. Life Sci. 2000) 3 23

Products for SEPW1 Gene

Sources for SEPW1 Gene

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