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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEPT7 Gene

protein-coding GIFtS: 51
GCID: GC07P035807

septin 7

(Previous name: CDC10 cell division cycle 10 homolog (S. cerevisiae) )
(Previous symbol: CDC10)

Search for SEPT7
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Septin 7¹ ²		CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae)¹
CDC10¹ ² ³ ⁵		NBLA02942²
CDC3¹ ²		CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog)²
SEPT7A¹ ²		Septin-7¹
CDC10 Protein Homolog² ³

External Ids:	HGNC: 1717¹	Entrez Gene: 989²	Ensembl: ENSG00000122545⁷	OMIM: 603151⁵	UniProtKB: Q16181³

Export aliases for SEPT7 gene to outside databases

Previous GC identifers: GC07P035615 GC07P035721

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT7:

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also

shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast

CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which

lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis

and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein

E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have

been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181

Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required

for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the

kinetochore. Plays a role in ciliogenesis and collective cell movements

Gene Wiki entry for SEPT7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEPT7 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 IRF-1 POU2F2 Egr-4 POU2F1 HOXA5 POU2F1a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SEPT7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.2 Ensembl cytogenetic band: 7p14.2 HGNC cytogenetic band: 7p14.2

SEPT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P035807: view genomic region (about GC identifiers)

Start:	35,840,542 bp from pter	End:	35,944,917 bp from pter
Size:	104,376 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 35,878,676-35,982,948

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181 (See protein sequence)

Recommended Name: Septin-7

Size: 437 amino acids; 50680 Da

Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular

membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are

assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a

hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the

absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of

SEPT2, SEPT6 and SEPT7. Interacts with SEPT5 and SEPT8 (By similarity). Interacts with SEPT9 and SEPT11

Subcellular location: Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage

furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Distributed throughout the cytoplasm in

prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the

cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By

similarity)

Miscellaneous: Coordinated expression with SEPT2 and SEPT6

Sequence caution: Sequence=AAB31337.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH67264.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH93640.2;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH93642.2; Type=Erroneous initiation;

Note=Translation N-terminally extended;

3 PDB 3D structures from and Proteopedia for SEPT7:

2QAG (3D)

3T5D (3D)

3TW4 (3D)

Secondary accessions: Q52M76 Q6NX50

Alternative splicing: 2 isoforms: Q16181-1 Q16181-2

Explore the universe of human proteins at neXtProt for SEPT7: NX_Q16181

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16181

SEPT7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001011553.2 NP_001229885.1 NP_001779.3

ENSEMBL proteins:

ENSP00000413507 ENSP00000387913 ENSP00000381992 ENSP00000344868 ENSP00000381993

ENSP00000444501 ENSP00000444567 ENSP00000438395 ENSP00000443706 ENSP00000444240

Human Recombinant Protein Products for SEPT7:

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	Novus Biologicals SEPT7 Proteins Novus Biologicals SEPT7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0001725	stress fiber	IDA	15485874
GO:0005634	nucleus	IDA	15485874
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

SEPT7 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEPT7 for domains About GeneDecksing

3 InterPro domains/families:

IPR000038 Cell_div_GTP-bd

IPR016491 Septin

IPR008115 Septin7

Graphical View of Domain Structure for InterPro Entry Q16181

ProtoNet protein and cluster: Q16181

2 Blocks protein families:

IPB000038 Cell division/GTP binding protein

IPB008115 Septin 7 signature

UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181

Similarity: Belongs to the septin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEPT7_HUMAN, Q16181

Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required

for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the

kinetochore. Plays a role in ciliogenesis and collective cell movements

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	TAS	8037772
GO:0005515	protein binding	IPI	17685441
GO:0005525	GTP binding	IEA	--

SEPT7 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEPT7

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEPT7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT7
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT7 (see all 40):
		hsa-miR-3164 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-605 hsa-miR-200a hsa-miR-628-3p hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT7 OriGene shRNA RFP: SEPT7 OriGene siRNA: SEPT7
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT7 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SEPT7

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/702 Interacting proteins for SEPT7 (Q16181^{2, 3} ENSP00000381992⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 702)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000910	cytokinesis	TAS	8037772
GO:0007049	cell cycle	--	--
GO:0007067	mitosis	IEA	--
GO:0016476	regulation of embryonic cell shape	ISS	--
GO:0051291	protein heterooligomerization	IDA	15485874

SEPT7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEPT7
Search CenterWatch for drugs/clinical trials and news about SEPT7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEPT7 gene (3 alternative transcripts):

NM_001011553.3 NM_001242956.1 NM_001788.5

Unigene Cluster for SEPT7:

Septin 7

Hs.191346 [show with all ESTs]

Unigene Representative Sequence: AB209677

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000435235(uc010kxc.3 uc011kat.2 uc011kau.2 uc011kav.2)

ENST00000493626 ENST00000475109 ENST00000425198 ENST00000473201 ENST00000492940

ENST00000485569 ENST00000399034 ENST00000350320 ENST00000399035 ENST00000469679

ENST00000537785 ENST00000494488 ENST00000493670 ENST00000432293

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEPT7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT7
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT7 (see all 40):
		hsa-miR-3164 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-605 hsa-miR-200a hsa-miR-628-3p hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT7 OriGene shRNA RFP: SEPT7 OriGene siRNA: SEPT7
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SEPT7

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Additional cDNA sequence:

AB209677.1 AK223225.1 AK223241.1 AK290545.1 AK297883.1 AK298453.1 AK300601.1 AL050392.1

BC022442.1 BC025987.2 BC067264.1 BC093640.1 BC093642.1 BC107718.1 BX571755.1 DQ232879.1

S72008.1

24/67 DOTS entries (see all 67):

DT.308399 DT.100886352 DT.100886331 DT.100886359 DT.101985258 DT.121043736 DT.100886338 DT.86835742

DT.100045052 DT.121043639 DT.121043616 DT.121043705 DT.121043741 DT.121043642 DT.100886361 DT.121043702

DT.121043623 DT.121043629 DT.121043646 DT.121043758 DT.97818303 DT.91859297 DT.92470247 DT.121043689

24/848 AceView cDNA sequences (see all 848):

BQ720002 AW473062 AW089619 BM676882 AI753160 AI634690 BP341160 AL047778

AI202475 CR625618 AW243825 BU740660 BX423492 AA290644 AW150451 AI570371

BM728959 BP343109 BU171544 BE348619 BE044042 BM679420 AI277618 BM698914

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT7 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15
SP1:																																							-
SP2:					-		-		-		-		-		-		-		-
SP3:									-		-				-		-		-
SP4:															-		-		-
SP5:																			-

ECgene alternative splicing isoforms for SEPT7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEPT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCTTGAA

About this image

SEPT7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

See SEPT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEPT7

SOURCE GeneReport for Unigene cluster: Hs.191346

UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Array including SEPT7:

Prostate Cancer in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEPT7 gene from 7/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEPT7¹	septin 7	89.61(n) 99.28(a)		420741 NM_001012559.1 NP_001012577.1
lizard (Anolis carolinensis)	Reptilia	SEPT7L⁶	--	96(a)	1 ↔ 1	6(46678898-46731262)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21677²	Xenopus laevis transcribed sequence with strong similarity more	83.39(n)		BQ731114.1
zebrafish (Danio rerio)	Actinopterygii	BC049418.1²	--	81.1(n)		394136 BC049418.1
fruit fly (Drosophila melanogaster)	Insecta	pnut¹	peanut	61.79(n) 66.59(a)		35801 NM_057716.3 NP_477064.1
worm (Caenorhabditis elegans)	Secernentea	unc-59¹	Protein UNC-59	52.83(n) 44.66(a)		173233 NM_060987.3 NP_493388.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC3(YLR314C)⁴ CDC3¹	Component of the septin ring of the mother-bud neck more⁴ Cdc3p¹	53.62(n)¹ 47.09(a)¹		12(764137-762575)⁴ 851024^{1, 4} NP_013418.2¹ NP_013418.1⁴

ENSEMBL Gene Tree for SEPT7 (if available)
TreeFam Gene Tree for SEPT7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEPT7 gene

SEPT3² SEPT9² SEPT14² SEPT4² SEPT1² SEPT12² SEPT6² SEPT7L²

SEPT11² SEPT2² SEPT10² SEPT8² SEPT5²

18/20 SIMAP similar genes for SEPT7 using alignment to 10 protein entries: SEPT7_HUMAN (see all proteins) (see all similar genes):

DKFZp586I031 DKFZp686F17268 Nbla02942 SEPT7L SEPT2 LOC392884

SEPT5 SEPT4 MAFK SEPT1 SEPT3 SEPT9

SEPT12 SEPT11 SEPT6 SEPT8 DKFZp547B243 SEPT10

SEPT7 for paralogs About GeneDecksing

5/17 Pseudogenes.org Pseudogenes for SEPT7 (see all 17)
PGOHUM00000242250 PGOHUM00000258741 PGOHUM00000259238 PGOHUM00000259239 PGOHUM00000259361

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141259053^1,2		--	35838718(+)	`GTTAGA/GTAAGT`	3	--	us2k¹		0	--	--	--	--
rs146953457^1,2		--	35838794(+)	`CAAGCA/CTAATA`	3	--	us2k¹		0	--	--	--	--
rs77222216^1,2	C,F	--	35838808(+)	`GGAGAG/ACTGGG`	3	--	us2k¹		2		WA EA	238
rs193225612^1,2		--	35838826(+)	`CTCAGA/GCAGTC`	3	--	us2k¹		0	--	--	--	--
rs148044946^1,2		--	35838971(+)	`TTGCAA/CCAGAC`	3	--	us2k¹		0	--	--	--	--
rs184362134^1,2		--	35838984(+)	`CATAAA/GCAGTT`	3	--	us2k¹		0	--	--	--	--
rs115400659^1,2		--	35839001(+)	`AAATGT/CAGACT`	3	--	us2k¹		1		WA	118
rs188032074^1,2		--	35839007(+)	`AGACTC/TACGAA`	3	--	us2k¹		0	--	--	--	--
rs191270153^1,2		--	35839009(+)	`ACTTAC/GGAAAT`	3	--	us2k¹		0	--	--	--	--
rs184099710^1,2		--	35839020(+)	`GGCATA/GTATCA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEPT7 (35840542 - 35944917 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SEPT7
4 CNVs: 94440 81903 3674 99921

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEPT7 for disorders About MalaCards

SEPT7 for disorders About GeneDecksing

OMIM gene information: 603151 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: SEPT7 (1 document)

Export disorders for SEPT7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEPT7 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with SEPT7)

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world of online information

Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. (PubMed id 8037772)^{1, 2, 3} Nakatsuru S.... Nakamura Y. (1994)
Structural analysis of septin 2, 6, and 7 complexes. (PubMed id 16914550)^{1, 2, 9} Low C. and Macara I.G. (2006)
Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. (PubMed id 18460473)^{1, 2} Zhu M....Yao X. (2008)
Structural insight into filament formation by mammalian septins. (PubMed id 17637674)^{1, 2} Sirajuddin M.... Wittinghofer A. (2007)
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)^{1, 2} Kremer B.E.... Macara I.G. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. (PubMed id 15485874)^{1, 2} Nagata K....Inagaki M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro. (PubMed id 14531065)^{1, 9} Koshelev Y.A....Georgiev G.P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 989	HGNC: 1717	AceView: CDC10	Ensembl:ENSG00000122545	euGenes: HUgn989
ECgene: SEPT7	H-InvDB: SEPT7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEPT7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SEPT7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SEPT7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SEPT7 gene:
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GeneCards and IP:
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