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SEPT7 Gene

protein-coding   GIFtS: 53
GCID: GC07P035807

Septin 7

(Previous name: CDC10 cell division cycle 10 homolog (S. cerevisiae))
(Previous symbol: CDC10)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Septin 71 2     NBLA029422
CDC101 2 3 5     SEPT7A2
CDC10 Protein Homolog2 3     CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog)2
CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae)1     septin-72
CDC32     

External Ids:    HGNC: 17171   Entrez Gene: 9892   Ensembl: ENSG000001225457   OMIM: 6031515   UniProtKB: Q161813   

Export aliases for SEPT7 gene to outside databases

Previous GC identifers: GC07P035615 GC07P035721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPT7 Gene:
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein
also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including
the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm
filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein
functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association
of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript
variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
(provided by RefSeq, Jul 2011)

GeneCards Summary for SEPT7 Gene:
SEPT7 (septin 7) is a protein-coding gene. Diseases associated with SEPT7 include folliculitis, and papillary thyroid carcinoma. GO annotations related to this gene include structural molecule activity and identical protein binding. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181
Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton.
Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE
with the kinetochore. Plays a role in ciliogenesis and collective cell movements

Gene Wiki entry for SEPT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPT7 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   IRF-1   POU2F2   Egr-4   POU2F1   HOXA5   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEPT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.2   Ensembl cytogenetic band:  7p14.2   HGNC cytogenetic band: 7p14.2

SEPT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P035807:  view genomic region     (about GC identifiers)

Start:
35,840,542 bp from pter      End:
35,944,917 bp from pter
Size:
104,376 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 35,878,676-35,982,948     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181 (See protein sequence)
Recommended Name: Septin-7  
Size: 437 amino acids; 50680 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation.
Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate
head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with
SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to
septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5 and SEPT8 (By similarity). Interacts
with SEPT9 and SEPT11
Miscellaneous: Coordinated expression with SEPT2 and SEPT6
Sequence caution: Sequence=AAB31337.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH67264.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH93640.2;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH93642.2; Type=Erroneous
initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for SEPT7:
2QAG (3D)        3T5D (3D)        3TW4 (3D)    
Secondary accessions: Q52M76 Q6NX50
Alternative splicing: 2 isoforms:  Q16181-1   Q16181-2   

Explore the universe of human proteins at neXtProt for SEPT7: NX_Q16181

Explore proteomics data for SEPT7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys89, Lys298, Lys313
  • Modification sites at PhosphoSitePlus

  • See SEPT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001011553.2  NP_001229885.1  NP_001779.3  

    ENSEMBL proteins: 
     ENSP00000413507   ENSP00000387913   ENSP00000381992   ENSP00000344868   ENSP00000381993  
     ENSP00000444501   ENSP00000438395   ENSP00000444240  

    SEPT7 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEPT7
    OriGene Protein Over-expression Lysate for SEPT7
    OriGene MassSpec for SEPT7
    OriGene Custom Protein Services for SEPT7
    GenScript Custom Purified and Recombinant Proteins Services for SEPT7
    Novus Biologicals SEPT7 Proteins
    Novus Biologicals SEPT7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SEPT7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SEPT7
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SEPT7
    OriGene Custom Antibody Services for SEPT7
    Novus Biologicals SEPT7 Antibodies
    Search for Antibodies for SEPT7 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SEPT7
    Search LSBio for Antibodies for SEPT7

    SEPT7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEPT7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEPT: Septins

    4 InterPro protein domains:
     IPR016491 Septin
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase
     IPR008115 Septin7

    Graphical View of Domain Structure for InterPro Entry Q16181

    ProtoNet protein and cluster: Q16181

    2 Blocks protein domains:
    IPB000038 Cell division/GTP binding protein
    IPB008115 Septin 7 signature


    UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181
    Similarity: Belongs to the septin family


    SEPT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPT7_HUMAN, Q16181
    Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton.
    Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE
    with the kinetochore. Plays a role in ciliogenesis and collective cell movements

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005198structural molecule activity TAS8037772
    GO:0005515protein binding IPI11584266
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IPI--
         
    SEPT7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEPT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEPT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT7

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEPT7:
    hsa-mir-200b-3p (MIRT024133), hsa-mir-200c-3p (MIRT021078), hsa-mir-34a-5p (MIRT047390), hsa-mir-141-3p (MIRT021657), hsa-mir-429 (MIRT016645), hsa-mir-200a-3p (MIRT020355), hsa-mir-30a-5p (MIRT007238), hsa-mir-26b-5p (MIRT029829)

    Block miRNA regulation of human, mouse, rat SEPT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPT7 (see all 40):
    hsa-miR-3164 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-605 hsa-miR-200a hsa-miR-628-3p hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEPT7
    Predesigned siRNA for gene silencing in human, mouse, rat SEPT7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SEPT7

    Clone
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    GenScript Custom all cDNA clones Services for SEPT7
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEPT7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEPT7_HUMAN, Q16181: Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage
    furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Distributed throughout the
    cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central
    spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin
    stress fibers (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0001725stress fiber IDA15485874
    GO:0005634nucleus IDA15485874
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    SEPT7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SEPT7
        RhoA Pathway
    Rho Family GTPases


        Pathway & Disease-focused RT2 Profiler PCR Array including SEPT7: 
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SEPT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEPT7 (Q161811, 2, 3 ENSP000003819924) via UniProtKB, MINT, STRING, and/or I2D (see all 756)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS8037772
    GO:0007049cell cycle ----
    GO:0007067mitosis IEA--
    GO:0016476regulation of embryonic cell shape ISS--
    GO:0051291protein heterooligomerization IDA15485874

    SEPT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEPT7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEPT7 gene (3 alternative transcripts): 
    NM_001011553.3  NM_001242956.1  NM_001788.5  

    Unigene Cluster for SEPT7:

    Septin 7
    Hs.191346  [show with all ESTs]
    Unigene Representative Sequence: AB209677
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435235(uc010kxc.3 uc011kat.2 uc011kau.2 uc011kav.2)
    ENST00000493626 ENST00000475109 ENST00000425198 ENST00000473201 ENST00000492940
    ENST00000485569 ENST00000399034 ENST00000350320 ENST00000399035 ENST00000469679
    ENST00000494488 ENST00000432293

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEPT7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPT7 (see all 40):
    hsa-miR-3164 hsa-miR-582-3p hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-605 hsa-miR-200a hsa-miR-628-3p hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEPT7
    Predesigned siRNA for gene silencing in human, mouse, rat SEPT7
    Clone
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    OriGene clones in human, mouse for SEPT7 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SEPT7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEPT7
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEPT7
      QuantiTect SYBR Green Assays in human, mouse, rat SEPT7
      QuantiFast Probe-based Assays in human, mouse, rat SEPT7

    Additional mRNA sequence: 

    AB209677.1 AK223225.1 AK223241.1 AK290545.1 AK297883.1 AK298453.1 AK300601.1 AL050392.1 
    BC022442.1 BC025987.2 BC067264.1 BC093640.1 BC093642.1 BC107718.1 BX571755.1 DQ232879.1 
    S72008.1 

    Selected DOTS entries (see all 67):

    DT.308399  DT.100886352  DT.100886331  DT.100886359  DT.101985258  DT.121043736  DT.100886338  DT.86835742 
    DT.100045052  DT.121043639  DT.121043616  DT.121043705  DT.121043741  DT.121043642  DT.100886361  DT.121043702 
    DT.121043623  DT.121043629  DT.121043646  DT.121043758  DT.97818303  DT.91859297  DT.92470247  DT.121043689 

    Selected AceView cDNA sequences (see all 848):

    BM698914 AI630074 AW150451 CB856686 CR609589 AA633993 T34415 BQ937990 
    BI041190 BU171544 BP343109 BM765607 CR625618 C05188 AI370513 BX423492 
    BX442096 AA948441 BM560800 AU136454 CB141877 BP336990 W40563 AA633339 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEPT7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                                                                                                    -                           
    SP2:              -     -     -     -     -     -     -     -                                                                                       
    SP3:                          -     -           -     -     -                                                                                       
    SP4:                                            -     -     -                                                                                       
    SP5:                                                        -                                                                                       


    ECgene alternative splicing isoforms for SEPT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPT7 expression in normal human tissues (normalized intensities)      SEPT7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCTTGAA
    SEPT7 Expression
    About this image


    SEPT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Lens
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
    SEPT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191346

    UniProtKB/Swiss-Prot: SEPT7_HUMAN, Q16181
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including SEPT7: 
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEPT7
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEPT7
    QuantiTect SYBR Green Assays in human, mouse, rat SEPT7
    QuantiFast Probe-based Assays in human, mouse, rat SEPT7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEPT7 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sept71 , 5 septin 71, 5 95.04(n)1
    99.08(a)1
      9 (10.25 cM)5
    2350721  NM_009859.41  NP_033989.21 
     252524395 
    chicken
    (Gallus gallus)
    Aves SEPT71 septin 7 89.45(n)
    99.04(a)
      420741  NM_001012559.1  NP_001012577.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPT76
    septin 7
    96(a)
    1 ↔ 1
    6(46678898-46731403)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.216772 Xenopus laevis transcribed sequence with strong similarity more 83.39(n)    BQ731114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049418.12   -- 81.1(n)   394136  BC049418.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pnut1 peanut 61.82(n)
    67.73(a)
      35801  NM_057716.3  NP_477064.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-591 unc-59 53.58(n)
    45.93(a)
      173233  NM_060987.4  NP_493388.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC3(YLR314C)4
    CDC31
    Component of the septin ring of the mother-bud neck more4
    CDC31
    53.19(n)1
    47.34(a)1
      12(764137-762575)4
    8510241, 4  NP_013418.21  NP_013418.14 


    ENSEMBL Gene Tree for SEPT7 (if available)
    TreeFam Gene Tree for SEPT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPT7 gene
    SEPT32  SEPT92  SEPT142  SEPT42  SEPT12  SEPT122  ENSG000002704662  SEPT62  
    SEPT112  SEPT22  SEPT102  SEPT82  SEPT52  
    Selected SIMAP similar genes for SEPT7 using alignment to 9 protein entries:     SEPT7_HUMAN (see all proteins) (see all similar genes):
    DKFZp586I031    DKFZp686F17268    Nbla02942    SEPT2    LOC392884    SEPT5
    SEPT4    MAFK    SEPT1    SEPT3    SEPT9    SEPT12
    SEPT11    SEPT6    SEPT8    DKFZp547B243    SEPT10    SEPT14

    SEPT7 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SEPT7 (see all 17)
    PGOHUM00000242250 PGOHUM00000258741 PGOHUM00000259238 PGOHUM00000259239 PGOHUM00000259361


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPT7 (see all 1944)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412590531,2
    --35838718(+) GTTAGA/GTAAGT 3 -- us2k10--------
    rs1469534571,2
    --35838794(+) CAAGCA/CTAATA 3 -- us2k10--------
    rs772222161,2
    C,F--35838808(+) GGAGAG/ACTGGG 3 -- us2k12Minor allele frequency- A:0.06WA EA 238
    rs1932256121,2
    --35838826(+) CTCAGA/GCAGTC 3 -- us2k10--------
    rs1124298041,2
    C--35838839(+) ACTCCG/AGAGGC 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1480449461,2
    --35838971(+) TTGCAA/CCAGAC 3 -- us2k10--------
    rs1843621341,2
    --35838984(+) CATAAA/GCAGTT 3 -- us2k10--------
    rs1154006591,2
    C,F--35839001(+) AAATGT/CAGACT 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1880320741,2
    --35839007(+) AGACTC/TACGAA 3 -- us2k10--------
    rs1912701531,2
    --35839009(+) ACTTAC/GGAAAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEPT7 (35840542 - 35944917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SEPT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2479660CNV Deletion19546169
    esv2734247CNV Deletion23290073
    esv2734248CNV Deletion23290073
    nsv887954CNV Loss21882294
    nsv887953CNV Loss21882294
    dgv7250n71CNV Loss21882294
    dgv2074e1CNV Complex17122850
    nsv469590CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPT7
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603151    OMIM disorders: --

    18 diseases for SEPT7:    About MalaCards
    folliculitis    papillary thyroid carcinoma    pulmonary function    down syndrome
    acute myeloid leukemia    parkinson's disease    systemic lupus erythematosus    lupus erythematosus
    thyroiditis    myeloid leukemia    cerebritis    leukemia
    schizophrenia    alzheimer's disease    prostate cancer    prostatitis
    malaria    neuronitis


    SEPT7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SEPT7
    Human Genome Epidemiology (HuGE) Navigator: SEPT7 (1 document)

    Export disorders for SEPT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPT7 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with SEPT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. (PubMed id 8037772)1, 2, 3 Nakatsuru S.... Nakamura Y. (Biochem. Biophys. Res. Commun. 1994)
    2. Structural analysis of septin 2, 6, and 7 complexes. (PubMed id 16914550)1, 2, 9 Low C. and Macara I.G. (J. Biol. Chem. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. (PubMed id 18460473)1, 2 Zhu M.... Yao X. (J. Biol. Chem. 2008)
    5. Structural insight into filament formation by mammalian septins. (PubMed id 17637674)1, 2 Sirajuddin M.... Wittinghofer A. (Nature 2007)
    6. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2 Kremer B.E.... Macara I.G. (Cell 2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. (PubMed id 15485874)1, 2 Nagata K.... Inagaki M. (J. Biol. Chem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 989 HGNC: 1717 AceView: CDC10 Ensembl:ENSG00000122545 euGenes: HUgn989
    ECgene: SEPT7 H-InvDB: SEPT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPT7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPT7 gene:
    Search GeneIP for patents involving SEPT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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