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Aliases for SEPT7 Gene

Aliases for SEPT7 Gene

  • Septin 7 2 3
  • CDC10 3 4 6
  • CDC10 Protein Homolog 3 4
  • CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog) 3
  • CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae) 2
  • Septin 7 Variant 4 3
  • NBLA02942 3
  • Septin-7 3
  • SEPT7A 3
  • CDC3 3

External Ids for SEPT7 Gene

Previous Symbols for SEPT7 Gene

  • CDC10

Summaries for SEPT7 Gene

Entrez Gene Summary for SEPT7 Gene

  • This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

GeneCards Summary for SEPT7 Gene

SEPT7 (Septin 7) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT7 Gene

  • Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.

Gene Wiki entry for SEPT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT7 Gene

Genomics for SEPT7 Gene

Genomic Location for SEPT7 Gene

Start:
35,800,932 bp from pter
End:
35,907,105 bp from pter
Size:
106,174 bases
Orientation:
Plus strand

Genomic View for SEPT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT7 Gene

Regulatory Elements for SEPT7 Gene

Proteins for SEPT7 Gene

  • Protein details for SEPT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16181-SEPT7_HUMAN
    Recommended name:
    Septin-7
    Protein Accession:
    Q16181
    Secondary Accessions:
    • Q52M76
    • Q6NX50

    Protein attributes for SEPT7 Gene

    Size:
    437 amino acids
    Molecular mass:
    50680 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5 and SEPT8 (By similarity). Interacts with SEPT9 and SEPT11.
    Miscellaneous:
    • Coordinated expression with SEPT2 and SEPT6
    SequenceCaution:
    • Sequence=AAB31337.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH67264.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93640.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93642.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEPT7 Gene

    Alternative splice isoforms for SEPT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT7 Gene

Proteomics data for SEPT7 Gene at MOPED

Post-translational modifications for SEPT7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys89, Lys298, and Lys313

No data available for DME Specific Peptides for SEPT7 Gene

Domains for SEPT7 Gene

Gene Families for SEPT7 Gene

HGNC:

Protein Domains for SEPT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q16181

UniProtKB/Swiss-Prot:

SEPT7_HUMAN
Domain:
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.:
    • Q16181
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.:
    • Q16181
genes like me logo Genes that share domains with SEPT7: view

No data available for Suggested Antigen Peptide Sequences for SEPT7 Gene

Function for SEPT7 Gene

Molecular function for SEPT7 Gene

UniProtKB/Swiss-Prot Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.

Gene Ontology (GO) - Molecular Function for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 8037772
GO:0005515 protein binding IPI 11584266
GO:0005525 GTP binding IEA --
GO:0042802 identical protein binding IPI 22064074
genes like me logo Genes that share ontologies with SEPT7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEPT7 Gene

Localization for SEPT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT7 Gene

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPT7 Gene COMPARTMENTS Subcellular localization image for SEPT7 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0001725 stress fiber IDA 15485874
GO:0005634 nucleus IDA 15485874
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SEPT7: view

Pathways for SEPT7 Gene

genes like me logo Genes that share pathways with SEPT7: view

Pathways by source for SEPT7 Gene

2 Qiagen pathways for SEPT7 Gene

Gene Ontology (GO) - Biological Process for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis TAS 8037772
GO:0007049 cell cycle --
GO:0007067 mitotic nuclear division IEA --
GO:0016476 regulation of embryonic cell shape ISS --
GO:0051291 protein heterooligomerization IDA 15485874
genes like me logo Genes that share ontologies with SEPT7: view

Transcripts for SEPT7 Gene

Unigene Clusters for SEPT7 Gene

Septin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:
SP7:
SP8: -
SP9: -

Relevant External Links for SEPT7 Gene

GeneLoc Exon Structure for
SEPT7
ECgene alternative splicing isoforms for
SEPT7

Expression for SEPT7 Gene

mRNA expression in normal human tissues for SEPT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT7 Gene

SOURCE GeneReport for Unigene cluster for SEPT7 Gene Hs.191346

mRNA Expression by UniProt/SwissProt for SEPT7 Gene

Q16181-SEPT7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SEPT7: view

No data available for mRNA differential expression in normal tissues for SEPT7 Gene

Orthologs for SEPT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEPT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPT7 35
  • 99.85 (n)
  • 99.77 (a)
SEPT7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC10 36
  • 100 (a)
OneToOne
SEPT7 35
  • 96.41 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SEPT7 35
  • 96.32 (n)
  • 99.76 (a)
SEPT7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sept7 35
  • 95.04 (n)
  • 99.08 (a)
Sept7 16
Sept7 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPT7 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT7 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sept7 35
  • 94.2 (n)
  • 99.31 (a)
chicken
(Gallus gallus)
Aves SEPT7 35
  • 89.45 (n)
  • 99.04 (a)
SEPT7 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPT7 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21677 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sept7 35
  • 84.21 (n)
  • 98.09 (a)
Str.11506 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hm:zeh0351 35
  • 77.91 (n)
  • 92.96 (a)
SEPT7 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007596 35
  • 62.65 (n)
  • 69.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta pnut 35
  • 61.82 (n)
  • 67.73 (a)
pnut 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-59 35
  • 53.58 (n)
  • 45.93 (a)
unc-59 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR111C 35
  • 49.96 (n)
  • 49.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC3 35
  • 53.19 (n)
  • 47.34 (a)
CDC3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04114g 35
  • 54.08 (n)
  • 47.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08297 35
  • 52.88 (n)
  • 54.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spn1 35
  • 53.18 (n)
  • 47.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for SEPT7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPT7 Gene

ENSEMBL:
Gene Tree for SEPT7 (if available)
TreeFam:
Gene Tree for SEPT7 (if available)

Paralogs for SEPT7 Gene

genes like me logo Genes that share paralogs with SEPT7: view

Variants for SEPT7 Gene

Sequence variations from dbSNP and Humsavar for SEPT7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs720739 -- 35,809,308(-) GAGAA(A/G)GAAAA intron-variant
rs763628 -- 35,802,694(-) TTCCA(C/T)AAATT intron-variant, upstream-variant-2KB
rs1055830 -- 35,876,040(+) CTGAC(A/G)TTTTG intron-variant
rs1055831 -- 35,876,066(+) TAATG(A/G)GACTT intron-variant
rs1055832 -- 35,876,126(+) ATGTT(C/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT7 Gene

Variant ID Type Subtype PubMed ID
nsv887953 CNV Loss 21882294
dgv2074e1 CNV Complex 17122850
nsv887954 CNV Loss 21882294
dgv7250n71 CNV Loss 21882294
esv2479660 CNV Deletion 19546169
esv2734247 CNV Deletion 23290073
nsv469590 CNV Complex 16826518
esv2734248 CNV Deletion 23290073

Relevant External Links for SEPT7 Gene

HapMap Linkage Disequilibrium report
SEPT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT7 Gene

Disorders for SEPT7 Gene

Relevant External Links for SEPT7

Genetic Association Database (GAD)
SEPT7
Human Genome Epidemiology (HuGE) Navigator
SEPT7
genes like me logo Genes that share disorders with SEPT7: view

No data available for UniProtKB/Swiss-Prot for SEPT7 Gene

Publications for SEPT7 Gene

  1. Structural analysis of septin 2, 6, and 7 complexes. (PMID: 16914550) Low C. … Macara I.G. (J. Biol. Chem. 2006) 3 4 23
  2. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. (PMID: 8037772) Nakatsuru S. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1994) 2 3 4
  3. Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro. (PMID: 14531065) Koshelev Y.A. … Georgiev G.P. (Dokl. Biochem. Biophys. 2003) 3 23
  4. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. (PMID: 15485874) Nagata K. … Inagaki M. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SEPT7 Gene

Sources for SEPT7 Gene

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