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Aliases for SEPT7 Gene

Aliases for SEPT7 Gene

  • Septin 7 2 3 5
  • CDC10 Protein Homolog 3 4
  • CDC10 3 4
  • CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog) 3
  • CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae) 2
  • Septin 7 Variant 4 3
  • NBLA02942 3
  • Septin-7 3
  • SEPT7A 3
  • CDC3 3

External Ids for SEPT7 Gene

Previous HGNC Symbols for SEPT7 Gene

  • CDC10

Previous GeneCards Identifiers for SEPT7 Gene

  • GC07P035615
  • GC07P035807
  • GC07P035721

Summaries for SEPT7 Gene

Entrez Gene Summary for SEPT7 Gene

  • This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

GeneCards Summary for SEPT7 Gene

SEPT7 (Septin 7) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and ERK Signaling. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is SEPT4.

UniProtKB/Swiss-Prot for SEPT7 Gene

  • Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).

Gene Wiki entry for SEPT7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT7 Gene

Genomics for SEPT7 Gene

Regulatory Elements for SEPT7 Gene

Enhancers for SEPT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G035724 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 -73.1 -73097 7.0 HDGF PKNOX1 WRNIP1 YBX1 ZNF143 ZNF207 FOS JUNB TBX21 NBN HERPUD2 SEPT7-AS1 SEPT7 LOC101930085 LOC100506725 GC07M035768
GH07G035709 1.4 Ensembl ENCODE dbSUPER 11.6 -91.2 -91231 0.6 ELF3 FOXA2 ARID4B BMI1 RAD21 CBX5 ZNF143 ETV6 IKZF2 CREM SEPT7-AS1 SEPT7 LOC100506725 PIR56078
GH07G035753 1.3 Ensembl ENCODE dbSUPER 10.8 -46.5 -46453 2.0 ATF1 TAL1 JUN CEBPG FOSL1 TCF12 FOXM1 ZNF316 GATA2 NCOR1 SEPT7-AS1 SEPT7 LOC101930085 GC07M035768 LOC100506725
GH07G035799 1.4 ENCODE dbSUPER 9.5 +0.4 357 4.5 HDGF HNRNPUL1 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SEPT7 LOC101930085 SEPT7-AS1 SEPT7P3 ENSG00000274328
GH07G035715 1.1 Ensembl ENCODE dbSUPER 11.3 -84.1 -84120 2.0 FOSL1 CBX8 ZNF366 EGR1 SCRT2 ZNF512 RAD21 LOC101930085 HERPUD2 SEPT7-AS1 SEPT7 LOC100506725 GC07M035768
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEPT7 on UCSC Golden Path with GeneCards custom track

Promoters for SEPT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000210837 268 3201 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for SEPT7 Gene

Chromosome:
7
Start:
35,800,932 bp from pter
End:
35,915,763 bp from pter
Size:
114,832 bases
Orientation:
Plus strand

Genomic View for SEPT7 Gene

Genes around SEPT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT7 Gene

Proteins for SEPT7 Gene

  • Protein details for SEPT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16181-SEPT7_HUMAN
    Recommended name:
    Septin-7
    Protein Accession:
    Q16181
    Secondary Accessions:
    • Q52M76
    • Q6NX50

    Protein attributes for SEPT7 Gene

    Size:
    437 amino acids
    Molecular mass:
    50680 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5 and SEPT8 (By similarity). Interacts with SEPT9 and SEPT11. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the SEPT12:SEPT7 association is mediated by the respective GTP-binding domains (PubMed:25588830).
    Miscellaneous:
    • Coordinated expression with SEPT2 and SEPT6.
    SequenceCaution:
    • Sequence=AAB31337.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH67264.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93640.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH93642.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEPT7 Gene

    Alternative splice isoforms for SEPT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT7 Gene

Post-translational modifications for SEPT7 Gene

  • Ubiquitination at Lys89, isoforms=2298, and Lys313
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEPT7 Gene

Domains & Families for SEPT7 Gene

Gene Families for SEPT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q16181

UniProtKB/Swiss-Prot:

SEPT7_HUMAN :
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT7: view

No data available for Suggested Antigen Peptide Sequences for SEPT7 Gene

Function for SEPT7 Gene

Molecular function for SEPT7 Gene

UniProtKB/Swiss-Prot Function:
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).

Gene Ontology (GO) - Molecular Function for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 8037772
GO:0005515 protein binding IPI 11584266
GO:0005525 GTP binding IEA --
GO:0042802 identical protein binding IPI 22064074
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with SEPT7: view
genes like me logo Genes that share phenotypes with SEPT7: view

Animal Models for SEPT7 Gene

MGI Knock Outs for SEPT7:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEPT7 Gene

Localization for SEPT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT7 Gene

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830). {ECO:0000250, ECO:0000269 PubMed:25588830}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEPT7 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0001725 stress fiber IDA 15485874
GO:0005634 nucleus IDA 15485874
genes like me logo Genes that share ontologies with SEPT7: view

Pathways & Interactions for SEPT7 Gene

genes like me logo Genes that share pathways with SEPT7: view

Pathways by source for SEPT7 Gene

2 Qiagen pathways for SEPT7 Gene

Gene Ontology (GO) - Biological Process for SEPT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis TAS 8037772
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007283 spermatogenesis IEA --
GO:0016476 regulation of embryonic cell shape ISS --
genes like me logo Genes that share ontologies with SEPT7: view

No data available for SIGNOR curated interactions for SEPT7 Gene

Drugs & Compounds for SEPT7 Gene

No Compound Related Data Available

Transcripts for SEPT7 Gene

Unigene Clusters for SEPT7 Gene

Septin 7:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:
SP7:
SP8: -
SP9: -

Relevant External Links for SEPT7 Gene

GeneLoc Exon Structure for
SEPT7
ECgene alternative splicing isoforms for
SEPT7

Expression for SEPT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEPT7 Gene

Protein differential expression in normal tissues from HIPED for SEPT7 Gene

This gene is overexpressed in Frontal cortex (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEPT7 Gene



Protein tissue co-expression partners for SEPT7 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for SEPT7 Gene:

Hs.191346

mRNA Expression by UniProt/SwissProt for SEPT7 Gene:

Q16181-SEPT7_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SEPT7 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Lung(4.6)
  • Kidney(4.5)
  • Skin(4.2)
  • Blood(3.8)
  • Intestine(3.6)
  • Spleen(3.4)
  • Heart(2.9)
  • Eye(2.8)
  • Pancreas(2.3)
  • Muscle(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SEPT7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEPT7 Gene

Orthologs for SEPT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEPT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC10 35
  • 100 (a)
OneToOne
SEPT7 34
  • 96.41 (n)
chimpanzee
(Pan troglodytes)
Mammalia SEPT7 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia SEPT7 34 35
  • 96.32 (n)
mouse
(Mus musculus)
Mammalia Sept7 34 16 35
  • 95.04 (n)
oppossum
(Monodelphis domestica)
Mammalia SEPT7 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sept7 34
  • 94.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT7 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPT7 34 35
  • 89.45 (n)
lizard
(Anolis carolinensis)
Reptilia SEPT7 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sept7 34
  • 84.21 (n)
Str.11506 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21677 34
zebrafish
(Danio rerio)
Actinopterygii SEPT7 35
  • 89 (a)
OneToOne
hm:zeh0351 34
  • 77.91 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007596 34
  • 62.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta pnut 35 34
  • 61.82 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-59 34 35
  • 53.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04114g 34
  • 54.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC3 34 37
  • 53.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR111C 34
  • 49.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spn1 34
  • 53.18 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08297 34
  • 52.88 (n)
Species where no ortholog for SEPT7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPT7 Gene

ENSEMBL:
Gene Tree for SEPT7 (if available)
TreeFam:
Gene Tree for SEPT7 (if available)

Paralogs for SEPT7 Gene

Paralogs for SEPT7 Gene

genes like me logo Genes that share paralogs with SEPT7: view

Variants for SEPT7 Gene

Sequence variations from dbSNP and Humsavar for SEPT7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000005122 -- 35,843,136(+) AGGTT(C/G)TTCCC intron-variant
rs1000024317 -- 35,878,154(+) TACAG(C/T)ACACT intron-variant
rs1000085905 -- 35,889,791(+) TGCCC(-/G)CCCCG intron-variant
rs1000098443 -- 35,801,895(+) TCCTC(C/T)TCCCG intron-variant, upstream-variant-2KB
rs1000151082 -- 35,884,284(+) TTGAG(C/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT7 Gene

Variant ID Type Subtype PubMed ID
dgv6321n100 CNV gain 25217958
esv2479660 CNV deletion 19546169
esv2734247 CNV deletion 23290073
esv2734248 CNV deletion 23290073
esv2759522 CNV gain 17122850
esv2761150 CNV gain 21179565
esv3612822 CNV gain 21293372
nsv1025977 CNV loss 25217958
nsv469590 CNV gain 16826518
nsv477768 CNV novel sequence insertion 20440878
nsv966777 CNV duplication 23825009
nsv966778 CNV duplication 23825009
nsv970816 CNV duplication 23825009

Relevant External Links for SEPT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEPT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SEPT7 Gene

Disorders for SEPT7 Gene

Relevant External Links for SEPT7

Genetic Association Database (GAD)
SEPT7
Human Genome Epidemiology (HuGE) Navigator
SEPT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEPT7

No disorders were found for SEPT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPT7 Gene

Publications for SEPT7 Gene

  1. Structural analysis of septin 2, 6, and 7 complexes. (PMID: 16914550) Low C. … Macara I.G. (J. Biol. Chem. 2006) 3 4 22 64
  2. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. (PMID: 8037772) Nakatsuru S. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 64
  3. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. (PMID: 25588830) Kuo Y.C. … Kuo P.L. (J. Cell. Sci. 2015) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. (PMID: 18460473) Zhu M. … Yao X. (J. Biol. Chem. 2008) 3 4 64

Products for SEPT7 Gene

Sources for SEPT7 Gene

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