External Ids for SEPT6 Gene
Previous GeneCards Identifiers for SEPT6 Gene
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEPT6 Gene
SEPT6 (Septin 6) is a Protein Coding gene. Diseases associated with SEPT6 include leukemia, acute myeloid. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT11.
UniProtKB/Swiss-Prot for SEPT6 Gene
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.