SEPT3 Gene
protein-coding GIFtS: 48
GCID: GC22P042372
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septin 3
(Previous symbol: SEP3)
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Aliases
for SEPT3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Septin 31 2 | | SEP31 2 3 5 | | BK250D10.31 | | Neuronal-Specific Septin 32 | | Neuronal-Specific Septin-32 |
Export aliases for SEPT3 gene to outside databasesPrevious GC identifers: GC22P038987 GC22P040616 GC22P040697 GC22P025339 |
Summaries
for SEPT3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEPT3:
This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression isupregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not beendetermined. Alternative splicing of this gene results in two transcript variants encoding different isoforms.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)
Gene Wiki entry for SEPT3
|
Genomic Views
for SEPT3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEPT3 gene promoter:
USF1 USF2 STAT5A USF-1:USF-2 C/EBPalpha Pax-3 USF-1 c-Myb Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEPT3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2SEPT3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P042372: view genomic region
(about GC identifiers)
Start:
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42,372,276 bp from pter |
End:
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42,394,225 bp from pter |
Size:
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21,950 bases |
Orientation:
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plus strand |
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Proteins
for SEPT3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03 (See
protein sequence)Recommended Name: Neuronal-specific septin-3 Size: 358 amino acids; 40704 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate withcellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (Bysimilarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity)
Sequence caution: Sequence=AAG00517.1; Type=Erroneous initiation; Sequence=AAG00518.1; Type=Erroneous initiation;Sequence=AAG00519.1; Type=Erroneous initiation; Sequence=AAI11780.2; Type=Erroneous initiation; Sequence=CAD38797.1;Type=Erroneous initiation; Sequence=CAG30458.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for SEPT3:3SOP (3D)
Secondary accessions: B1AHR0 Q2NKJ7 Q59GF7 Q6IBZ6 Q8N3P3 Q9HD35Alternative splicing: 3 isoforms: Q9UH03-1 Q9UH03-2 Q9UH03-3 Explore the universe of human proteins at neXtProt for SEPT3: NX_Q9UH03
Post-translational modifications:
Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UH03
SEPT3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061979.3 NP_663786.2
ENSEMBL proteins: ENSP00000391416 ENSP00000379704 ENSP00000383956 ENSP00000379703 ENSP00000379695 ENSP00000291236 ENSP00000332866
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SEPT3 for ontologies About GeneDecksing
SEPT3 Antibody Products:
Assay Products for SEPT3: |
Protein
Domains /
Families
for SEPT3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEPT3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UH03ProtoNet protein and cluster: Q9UH03 2 Blocks protein families: IPB000038 Cell division/GTP binding protein IPB008114 Septin 3 signature
UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03Similarity: Belongs to the septin family |
Function
for SEPT3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)Induction: Up-regulated during neuronal differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SEPT3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEPT3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005525 | GTP binding |
IEA | -- |
SEPT3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SEPT3: Sept3tm1Keng Sept3tm1Wtr
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Sept3):
SEPT3 for phenotypes About GeneDecksing
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Pathways & Interactions
for SEPT3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPT3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/36 Interacting proteins for SEPT3 (Q9UH032, 3 ENSP000003797044) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SEPT3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEPT3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SEPT3 for compounds About GeneDecksing
 Browse Tocris compounds for SEPT3
2 Novoseek chemical compound relationships for SEPT3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoic acid |
38.4 |
1 |
15200239 (1) |
| serine |
25.9 |
1 |
15107017 (1) |
Search CenterWatch for drugs/clinical trials and news about SEPT3
|
Transcripts
for SEPT3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEPT3 gene (3 alternative transcripts): NM_019106.5 NM_145733.2 NM_145734.1 Unigene Cluster for SEPT3: Septin 3 Hs.120483 [show with all ESTs]Unigene Representative Sequence: NM_0191068 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449288 ENST00000396426(uc003bbr.4) ENST00000406029 ENST00000396425(uc003bbs.4 uc011apj.2)
ENST00000396417 ENST00000460267 ENST00000291236 ENST00000328414(uc010gys.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SEPT3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEPT3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT3 |
Additional cDNA sequence: AB209152.1 AF285107.1 AF285108.1 AF285109.1 AK290037.1 AK299919.1 AL833942.1 BC111779.1 CR456572.1 13 DOTS entries: DT.86840677 DT.100683348 DT.100819854 DT.95270345 DT.100819858 DT.120642986 DT.120642993 DT.120643001 DT.101965960 DT.120643014 DT.403287 DT.92423021 DT.92423023 24/214 AceView cDNA sequences (see all 214): BX345218 BX280551 D54252 BP348877 BQ937737 CA388736 CR611488 T33727 BU731445 BM771185 CR456572 BQ071318 BM666855 BM695073 BM449683 CR456400 BM708052 NM_145733 BE891766 BP348363 AI369698 AA812560 AF285107 AA812559
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | - | | | | |
| SP4: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEPT3
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Expression
for SEPT3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEPT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTTTGCG
About this image
See SEPT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEPT3
SOURCE GeneReport for Unigene cluster: Hs.120483
UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03Tissue specificity: Brain-specific
SABiosciences Custom PCR Arrays for SEPT3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT3 |
Orthologs
for SEPT3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for SEPT3 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SEPT31 |
septin 3 |
84.57(n)
94.64(a) |
|
427899 XM_425473.3 XP_425473.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SEPT36 |
-- |
92(a) |
1 ↔ 1 |
5(27025259-27033459) |
zebrafish
(Danio rerio) |
Actinopterygii |
sept36CABZ01061914.26 |
-- |
78(a)32(a) |
1 ↔ 1possible ortholog |
1(46087335-46104648) 19(12015392-12049272) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-596 |
UNCoordinated family member (unc-59) |
28(a) |
possible ortholog |
I(13629214-13633485) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CDC10(YCR002C)4
CDC101 |
Component of the septin ring that is required for cytokinesis; more4
Cdc10p1 |
52.31(n)1
47.92(a)1 |
|
3(118348-117380)4
8503581, 4 NP_009928.11, 4 |
ENSEMBL Gene Tree for SEPT3 (if available)
TreeFam Gene Tree for SEPT3 (if available) |
Paralogs
for SEPT3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEPT3 gene
- SEPT92 SEPT142 SEPT42 SEPT12 SEPT72 SEPT122 SEPT62 SEPT7L2
- SEPT112 SEPT22 SEPT102 SEPT82 SEPT52
17 SIMAP similar genes for SEPT3 using alignment to 5 protein entries: SEPT3_HUMAN (see all proteins):SEPT9 SEPT12 MAFK Nbla02942 SEPT4 SEPT2
DKFZp686F17268 SEPT7 SEPT7L SEPT1 SEPT5 SEPT6
SEPT11 DKFZp547B243 SEPT10 SEPT14 SEPT8
SEPT3 for paralogs About GeneDecksing
|
Genomic Variants
for SEPT3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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