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Aliases for SEPT3 Gene

Aliases for SEPT3 Gene

  • Septin 3 2 3
  • SEP3 3 4 6
  • Neuronal-Specific Septin 3 3
  • Neuronal-Specific Septin-3 3
  • BK250D10.3 3

External Ids for SEPT3 Gene

Previous HGNC Symbols for SEPT3 Gene

  • SEP3

Previous GeneCards Identifiers for SEPT3 Gene

  • GC22P038987
  • GC22P040616
  • GC22P040697
  • GC22P042372
  • GC22P025339

Summaries for SEPT3 Gene

Entrez Gene Summary for SEPT3 Gene

  • This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEPT3 Gene

SEPT3 (Septin 3) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT3 Gene

  • Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Gene Wiki entry for SEPT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT3 Gene

Genomics for SEPT3 Gene

Regulatory Elements for SEPT3 Gene

Genomic Location for SEPT3 Gene

41,976,272 bp from pter
41,998,221 bp from pter
21,950 bases
Plus strand

Genomic View for SEPT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT3 Gene

Proteins for SEPT3 Gene

  • Protein details for SEPT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal-specific septin-3
    Protein Accession:
    Secondary Accessions:
    • B1AHR0
    • Q2NKJ7
    • Q59GF7
    • Q6IBZ6
    • Q8N3P3
    • Q9HD35

    Protein attributes for SEPT3 Gene

    358 amino acids
    Molecular mass:
    40704 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
    • Sequence=AAG00517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG00518.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG00519.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11780.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38797.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG30458.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEPT3 Gene

    Alternative splice isoforms for SEPT3 Gene


neXtProt entry for SEPT3 Gene

Proteomics data for SEPT3 Gene at MOPED

Post-translational modifications for SEPT3 Gene

  • Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).
  • Ubiquitination at Lys226
  • Modification sites at PhosphoSitePlus

Other Protein References for SEPT3 Gene

No data available for DME Specific Peptides for SEPT3 Gene

Domains for SEPT3 Gene

Gene Families for SEPT3 Gene


Protein Domains for SEPT3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UH03
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT3: view

No data available for Suggested Antigen Peptide Sequences for SEPT3 Gene

Function for SEPT3 Gene

Molecular function for SEPT3 Gene

UniProtKB/Swiss-Prot Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
UniProtKB/Swiss-Prot Induction: Up-regulated during neuronal differentiation.

Gene Ontology (GO) - Molecular Function for SEPT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SEPT3: view

Phenotypes for SEPT3 Gene

genes like me logo Genes that share phenotypes with SEPT3: view

Animal Models for SEPT3 Gene

MGI Knock Outs for SEPT3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SEPT3 Gene

Localization for SEPT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for SEPT3 Gene COMPARTMENTS Subcellular localization image for SEPT3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SEPT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0030054 cell junction IEA --
GO:0031105 septin complex --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SEPT3: view

Pathways for SEPT3 Gene

genes like me logo Genes that share pathways with SEPT3: view

Pathways by source for SEPT3 Gene

1 KEGG pathway for SEPT3 Gene

Gene Ontology (GO) - Biological Process for SEPT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SEPT3: view

Compounds for SEPT3 Gene

(2) Novoseek inferred chemical compound relationships for SEPT3 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 38.4 1
serine 25.9 1
genes like me logo Genes that share compounds with SEPT3: view

Transcripts for SEPT3 Gene

Unigene Clusters for SEPT3 Gene

Septin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

Relevant External Links for SEPT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEPT3 Gene

mRNA expression in normal human tissues for SEPT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPT3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (7.0), Brain - Frontal Cortex (BA9) (6.2), Brain - Cortex (5.8), Brain - Amygdala (5.5), Brain - Hippocampus (5.1), and Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT3 Gene

SOURCE GeneReport for Unigene cluster for SEPT3 Gene Hs.120483

mRNA Expression by UniProt/SwissProt for SEPT3 Gene

Tissue specificity: Brain-specific.
genes like me logo Genes that share expressions with SEPT3: view

Orthologs for SEPT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEPT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEPT3 35
  • 100 (n)
  • 100 (a)
SEPT3 36
  • 100 (a)
(Bos Taurus)
Mammalia SEPT3 35
  • 94.4 (n)
  • 99.16 (a)
SEPT3 36
  • 99 (a)
(Canis familiaris)
Mammalia SEPT3 35
  • 95.07 (n)
  • 99.44 (a)
SEPT3 36
  • 98 (a)
(Mus musculus)
Mammalia Sept3 35
  • 93.11 (n)
  • 99.69 (a)
Sept3 16
Sept3 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia SEPT3 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Sept3 35
  • 92.55 (n)
  • 98.32 (a)
(Gallus gallus)
Aves SEPT3 35
  • 84.99 (n)
  • 95.45 (a)
SEPT3 36
  • 91 (a)
(Anolis carolinensis)
Reptilia SEPT3 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sept3 35
  • 80.22 (n)
  • 91.1 (a)
(Danio rerio)
Actinopterygii sept3 35
  • 74.1 (n)
  • 87 (a)
sept3 36
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC3 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8439 36
  • 54 (a)
Species with no ortholog for SEPT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT3 Gene

Gene Tree for SEPT3 (if available)
Gene Tree for SEPT3 (if available)

Paralogs for SEPT3 Gene

genes like me logo Genes that share paralogs with SEPT3: view

Variants for SEPT3 Gene

Sequence variations from dbSNP and Humsavar for SEPT3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs133292 -- 41,986,744(+) GATCC(A/G)CCTGC intron-variant
rs133293 -- 41,986,793(+) ACCAC(A/G)CCCGG intron-variant
rs133294 -- 41,986,801(+) CGGCC(C/T)GAAAC intron-variant
rs133295 -- 41,988,121(+) GTCGG(A/G)GGGAG intron-variant
rs739293 -- 41,977,644(+) GGGGG(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT3 Gene

Variant ID Type Subtype PubMed ID
dgv4979n71 CNV Loss 21882294

Relevant External Links for SEPT3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT3 Gene

Disorders for SEPT3 Gene

(1) Novoseek inferred disease relationships for SEPT3 Gene

Disease -log(P) Hits PubMed IDs
teratocarcinoma 71.8 1

Relevant External Links for SEPT3

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SEPT3: view

No data available for UniProtKB/Swiss-Prot for SEPT3 Gene

Publications for SEPT3 Gene

  1. Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation. (PMID: 11322766) Methner A. … Lewerenz J. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals. (PMID: 15107017) Xue J. … Robinson P.J. (Biochem. J. 2004) 3 23
  3. The structure and properties of septin 3: a possible missing link in septin filament formation. (PMID: 23163726) Macedo J.N. … Araujo A.P. (Biochem. J. 2013) 3 4
  4. Septin 3 gene polymorphism in Alzheimer's disease. (PMID: 15200238) Takehashi M. … Ueda K. (Gene Expr. 2004) 3 23
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for SEPT3 Gene

Sources for SEPT3 Gene

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