Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPT3 Gene

protein-coding   GIFtS: 54
GCID: GC22P042372

Septin 3


(Previous symbol: SEP3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Septin 31 2
SEP31 2 3 5
bK250D10.32
Neuronal-Specific Septin 32
Neuronal-Specific Septin-32

External Ids:    HGNC: 107501   Entrez Gene: 559642   Ensembl: ENSG000001001677   OMIM: 6083145   UniProtKB: Q9UH033   

Export aliases for SEPT3 gene to outside databases

Previous GC identifers: GC22P038987 GC22P040616 GC22P040697 GC22P025339


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT3 Gene:
This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression
is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not
been determined. Alternative splicing of this gene results in two transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEPT3 Gene: 
SEPT3 (septin 3) is a protein-coding gene. Diseases associated with SEPT3 include teratocarcinoma, and temporal lobe epilepsy. GO annotations related to this gene include GTP binding and molecular_function. An important paralog of this gene is SEPT9.

UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

Gene Wiki entry for SEPT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPT3 gene promoter:
         USF1   USF2   STAT5A   USF-1:USF-2   C/EBPalpha   Pax-3   USF-1   c-Myb   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SEPT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

SEPT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P042372:  view genomic region     (about GC identifiers)

Start:
42,372,276 bp from pter      End:
42,394,225 bp from pter
Size:
21,950 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03 (See protein sequence)
Recommended Name: Neuronal-specific septin-3  
Size: 358 amino acids; 40704 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By
similarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity)
Sequence caution: Sequence=AAG00517.1; Type=Erroneous initiation; Sequence=AAG00518.1; Type=Erroneous initiation;
Sequence=AAG00519.1; Type=Erroneous initiation; Sequence=AAI11780.2; Type=Erroneous initiation;
Sequence=CAD38797.1; Type=Erroneous initiation; Sequence=CAG30458.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SEPT3:
3SOP (3D)    
Secondary accessions: B1AHR0 Q2NKJ7 Q59GF7 Q6IBZ6 Q8N3P3 Q9HD35
Alternative splicing: 3 isoforms:  Q9UH03-1   Q9UH03-2   Q9UH03-3   

Explore the universe of human proteins at neXtProt for SEPT3: NX_Q9UH03

Explore proteomics data for SEPT3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UH03

  • SEPT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEPT3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_061979.3  NP_663786.2  

    ENSEMBL proteins: 
     ENSP00000391416   ENSP00000379704   ENSP00000383956   ENSP00000379703   ENSP00000379695  
     ENSP00000291236   ENSP00000332866  

    Human Recombinant Protein Products for SEPT3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SEPT3
    OriGene Protein Over-expression Lysate for SEPT3
    OriGene MassSpec for SEPT3 
    OriGene Custom Protein Services for SEPT3
    GenScript Custom Purified and Recombinant Proteins Services for SEPT3
    Novus Biologicals SEPT3 Protein
    Novus Biologicals SEPT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0031105septin complex IEA--
    GO:0045202synapse IEA--

    SEPT3 for ontologies           About GeneDecksing



    SEPT3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SEPT3
    OriGene Custom Antibody Services for SEPT3
    GenScript Custom Superior Antibodies Services for SEPT3
    Novus Biologicals SEPT3 Antibodies
    Abcam antibodies for SEPT3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SEPT3
    LSBio Antibodies in human, mouse, rat for SEPT3 

    Assay Products for SEPT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEPT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEPT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SEPT: Septins

    4 InterPro protein domains:
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase
     IPR008114 Septin3
     IPR016491 Septin

    Graphical View of Domain Structure for InterPro Entry Q9UH03

    ProtoNet protein and cluster: Q9UH03

    2 Blocks protein domains:
    IPB000038 Cell division/GTP binding protein
    IPB008114 Septin 3 signature


    UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03
    Similarity: Belongs to the septin family


    SEPT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPT3_HUMAN, Q9UH03
    Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)
    Induction: Up-regulated during neuronal differentiation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    SEPT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sept3):
     nervous system  normal 

    SEPT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SEPT3: Sept3tm1Keng Sept3tm1Wtr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT3
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT3 (see all 86):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-miR-342-3p hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEPT3
    Sirion Biotech Customized adenovirus for overexpression of SEPT3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SEPT3 (see all 14)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SEPT3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT3
    Sirion Biotech Customized lentivirus for stable overexpression of SEPT3 
                         Customized lentivirus expression plasmids for stable overexpression of SEPT3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEPT3
    Search LifeMap BioReagents cell lines for SEPT3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEPT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEPT3):
        Bacterial invasion of epithelial cells


    SEPT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/36 Interacting proteins for SEPT3 (Q9UH032, 3 ENSP000003797044) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WBP2Q969T92, 3, ENSP000002548064MINT-65566 I2D: score=4 STRING: ENSP00000254806
    MAPK6Q166592, 3MINT-8261912 I2D: score=2 
    PRKG1Q139763, ENSP000003630924I2D: score=1 STRING: ENSP00000363092
    SEPT11Q9NVA23, ENSP000002648934I2D: score=1 STRING: ENSP00000264893
    SEPT6Q141413, ENSP000003415244I2D: score=1 STRING: ENSP00000341524
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS--
    GO:0007049cell cycle ----

    SEPT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEPT3

    2 Novoseek inferred chemical compound relationships for SEPT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 38.4 1 15200239 (1)
    serine 25.9 1 15107017 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEPT3 gene (3 alternative transcripts): 
    NM_019106.5  NM_145733.2  NM_145734.1  

    Unigene Cluster for SEPT3:

    Septin 3
    Hs.120483  [show with all ESTs]
    Unigene Representative Sequence: NM_019106
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449288 ENST00000396426(uc003bbr.4) ENST00000406029 ENST00000396425(uc003bbs.4 uc011apj.2)
    ENST00000396417 ENST00000460267 ENST00000291236 ENST00000328414(uc010gys.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT3
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT3 (see all 86):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-miR-342-3p hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT3
    Clone
    Products:
         
    OriGene clones in human, mouse for SEPT3 (see all 14)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SEPT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT3
    Sirion Biotech Customized lentivirus for stable overexpression of SEPT3 
                         Customized lentivirus expression plasmids for stable overexpression of SEPT3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEPT3
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT3

    Additional mRNA sequence: 

    AB209152.1 AF285107.1 AF285108.1 AF285109.1 AK290037.1 AK299919.1 AL833942.1 BC111779.1 
    CR456572.1 

    13 DOTS entries:

    DT.86840677  DT.100683348  DT.100819854  DT.95270345  DT.100819858  DT.120642986  DT.120642993  DT.120643001 
    DT.101965960  DT.120643014  DT.403287  DT.92423021  DT.92423023 

    24/214 AceView cDNA sequences (see all 214):

    AI369698 BM708052 BQ937737 AK128138 BX345218 CR456400 BM771840 AW169980 
    AA666390 AI220013 BM770744 BQ924462 BQ071318 CR611488 BM770133 NM_145733 
    CR618252 BM449683 BQ232940 BF508668 BX280551 Z38211 BF528667 AF285108 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                -                                                                                       
    SP2:                                -                                                                             -         
    SP3:                                -     -     -     -                       -     -                             -         
    SP4:        -     -     -           -                                                                                       
    SP5:                                -                                                                                       


    ECgene alternative splicing isoforms for SEPT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPT3 expression in normal human tissues (normalized intensities)      SEPT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTTTGCG
    SEPT3 Expression
    About this image


    SEPT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             ESI-017   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Primitive Spinal Cord
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neuron (HN)   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See SEPT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPT3

    SOURCE GeneReport for Unigene cluster: Hs.120483

    UniProtKB/Swiss-Prot: SEPT3_HUMAN, Q9UH03
    Tissue specificity: Brain-specific

        SABiosciences Custom PCR Arrays for SEPT3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEPT3
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEPT3 gene from 18 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia SEPT31 septin 3 100(n)
    100(a)
      458874  XM_515166.4  XP_515166.3 
    mouse
    (Mus musculus)
    Mammalia Sept31 , 5 septin 31, 5 93.11(n)1
    99.69(a)1
      15 (38.56 cM)5
    240501  NM_011889.21  NP_036019.21 
     822749355 
    rat
    (Rattus norvegicus)
    Mammalia Sept31 septin 3 92.55(n)
    98.32(a)
      56003  NM_019375.1  NP_062248.1 
    cow
    (Bos taurus)
    Mammalia SEPT31 septin 3 94.4(n)
    99.16(a)
      618235  NM_001076949.1  NP_001070417.1 
    dog
    (Canis familiaris)
    Mammalia SEPT31 septin 3 95.07(n)
    99.44(a)
      481227  XM_843889.2  XP_848982.2 
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    39(a)
    possible ortholog
    1(13438905-13439846)
    platypus
    (Ornithorhynchus anatinus)
    Mammalia SEPT36
    septin 3
    94(a)
    1 ↔ 1
    Contig1041(305690-315646)
    chicken
    (Gallus gallus)
    Aves SEPT31 septin 3 84.57(n)
    94.64(a)
      427899  XM_425473.3  XP_425473.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEPT36
    septin 3
    93(a)
    1 ↔ 1
    5(27011389-27033459)
    zebrafish
    (Danio rerio)
    Actinopterygii sept36
    septin 3
    78(a)
    1 ↔ 1
    1(46087335-46104648)
    sea squirt
    (Ciona savignyi)
    Ascidiacea CSA.84396
    Uncharacterized protein
    54(a)
    1 → many
    reftig_107(232574-241161)
    fruit fly
    (Drosophila melanogaster)
    Insecta Sep26
    Sep56
    Sep5
    30(a)
    30(a)
    possible ortholog
    possible ortholog
    3R(16411851-16414085)
    2R(3847638-3849427)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-616
    Protein UNC-61, isoform a
    23(a)
    possible ortholog
    V(14731095-14734237)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC10(YCR002C)4
    CDC101
    Component of the septin ring that is required for cytokinesis; more4
    Cdc10p1
    52.31(n)1
    47.92(a)1
      3(118348-117380)4
    8503581, 4  NP_009928.11, 4 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AAR001C1 AAR001Cp 58.1(n)
    51.04(a)
      4618433  NM_207895.1  NP_982542.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0F12848g1 hypothetical protein 54.68(n)
    50(a)
      2895908  XM_455659.1  XP_455659.1 
    fission yeast
    (Schizosaccharomyces pombe)
    Schizosaccharomycetes spn21 septin Spn2 52.38(n)
    46.98(a)
      2543513   NP_593159.1 
    bread mold
    (Neurospora crassa)
    Ascomycetes NCU035151 cell division control protein 10 59.37(n)
    50(a)
      3872018  XM_950778.2  XP_955871.1 
            Species with no ortholog for SEPT3

    ENSEMBL Gene Tree for SEPT3 (if available)
    TreeFam Gene Tree for SEPT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEPT3 gene
    SEPT92  SEPT142  SEPT42  SEPT12  SEPT122  SEPT72  ENSG000002704662  SEPT62  
    SEPT112  SEPT22  SEPT102  SEPT82  SEPT52  
    16 SIMAP similar genes for SEPT3 using alignment to 5 protein entries:     SEPT3_HUMAN (see all proteins):
    SEPT9    SEPT12    MAFK    Nbla02942    SEPT4    SEPT2
    DKFZp686F17268    SEPT7    SEPT1    SEPT5    SEPT6    SEPT11
    DKFZp547B243    SEPT10    SEPT14    SEPT8

    SEPT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/458 SNPs in SEPT3 are shown (see all 458)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400297311,2
    --26287142(+) AAAAA-/GAAAAA 1 -- int10--------
    rs1410296061,2
    C--26287188(+) CCTCCC/TACGTG 1 -- int10--------
    rs113809851,2
    C--26297009(+) TTCCCT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1835183431,2
    --42370931(+) CTAGCA/GCTTTA 2 -- us2k10--------
    rs57511911,2
    C,F,A,H--42370991(+) TGAGAC/TAATGA 2 -- us2k1 tfbs322Minor allele frequency- T:0.50NS EA NA WA 2518
    rs796226961,2
    C,F--42371137(+) GCCTTG/ATATAT 2 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1870357651,2
    --42371194(+) GACATC/TCATTT 2 -- us2k10--------
    rs48204511,2
    C,F--42371333(+) AGTTTC/TTGGGT 2 -- us2k1 tfbs312Minor allele frequency- T:0.24NA WA CSA EA 376
    rs1903735631,2
    --42371499(+) GCAGCA/CCAGCC 2 -- us2k10--------
    rs1821868831,2
    --42371500(+) CAGCCC/TAGCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEPT3 (42372276 - 42394225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEPT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4979n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPT3
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608314    OMIM disorders: --

    4 diseases for SEPT3:    About MalaCards
    teratocarcinoma    temporal lobe epilepsy    neuronitis    alzheimer's disease


    SEPT3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SEPT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teratocarcinoma 71.8 1 15200239 (1)

    Human Genome Epidemiology (HuGE) Navigator: SEPT3 (1 document)

    Export disorders for SEPT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPT3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with SEPT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation. (PubMed id 11322766)1, 2, 9 Methner A.... Lewerenz J. (2001)
    2. The structure and properties of septin 3: a possible missing link in septin filament formation. (PubMed id 23163726)1, 2 Macedo J.N.... Araujo A.P. (2013)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals. (PubMed id 15107017)1, 9 Xue J....Robinson P.J. (2004)
    6. Septin 3 gene polymorphism in Alzheimer's disease. (PubMed id 15200238)1, 9 Takehashi M....Ueda K. (2004)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55964 HGNC: 10750 AceView: SEPT3andMGC26816 Ensembl:ENSG00000100167 euGenes: HUgn55964
    ECgene: SEPT3 Kegg: 55964 H-InvDB: SEPT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPT3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEPT3 gene:
    Search GeneIP for patents involving SEPT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SEPT3   OriGene RNAi products in human, mouse, rat for SEPT3  
     OriGene qPCR primer pairs and template standards for SEPT3   OriGene Protein Over-expression Lysate for SEPT3  
     OriGene MassSpec something-or-other for SEPT3   OriGene clones in human, mouse for SEPT3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEPT3   OriGene Purified Protein for SEPT3  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEPT3   OriGene Custom Protein Services for SEPT3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEPT3
     QIAGEN SeqTarget long-range PCR primers for resequencing SEPT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT3
     GenScript Custom Purified and Recombinant Proteins Services for SEPT3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SEPT3
     GenScript Custom Assay Services for SEPT3 GenScript Custom Superior Antibodies Services for SEPT3
     GenScript Custom overexpressing Cell Line Services for SEPT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SEPT3 promoter
     Search Chromatin IP Primers for SEPT3
     RT2 qPCR Primer Assay in human, mouse, rat SEPT3
     Search GNC Networks for SEPT3
     SABiosciences Custom PCR Arrays for SEPT3
     Search Tocris compounds for SEPT3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEPT3 antibodies
     SEPT3 proteins
     SEPT3 lysates
     Antibodies for SEPT3
     See all of Abcam's Antibodies, Kits and Proteins for SEPT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SEPT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SEPT3
     Browse SwitchGear Promoter luciferase reporter plasmids for SEPT3
     ThermoFisher Antibodies for SEPT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPT3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPT3
    Customized:
     lentivirus for stable overexpression of SEPT3
     lentivirus expression plasmids for stable overexpression of SEPT3
     adenovirus for overexpression of SEPT3
     LSBio Antibodies in human, mouse, rat for SEPT3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEPT3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4