Aliases for SEPT2 Gene
External Ids for SEPT2 Gene
Previous HGNC Symbols for SEPT2 Gene
Previous GeneCards Identifiers for SEPT2 Gene
GeneCards Summary for SEPT2 Gene
SEPT2 (Septin 2) is a Protein Coding gene. Diseases associated with SEPT2 include gastrointestinal anthrax and acute orbital inflammation. Among its related pathways are ERK Signaling and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include GTP binding and enzyme regulator activity. An important paralog of this gene is SEPT6.
UniProtKB/Swiss-Prot for SEPT2 Gene
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.