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Aliases for SEPT2 Gene

Aliases for SEPT2 Gene

  • Septin 2 2 3
  • DIFF6 3 4 6
  • NEDD5 3 4 6
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 5 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 5 2 3
  • NEDD-5 3 4
  • Septin-2 3
  • KIAA0158 4
  • Pnutl3 3
  • HNedd5 3

External Ids for SEPT2 Gene

Previous HGNC Symbols for SEPT2 Gene

  • DIFF6
  • NEDD5

Previous GeneCards Identifiers for SEPT2 Gene

  • GC02P241975
  • GC02P242254
  • GC02P234010

Summaries for SEPT2 Gene

GeneCards Summary for SEPT2 Gene

SEPT2 (Septin 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and CDC42 signaling events. GO annotations related to this gene include GTP binding and enzyme regulator activity. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT2 Gene

  • Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Gene Wiki entry for SEPT2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT2 Gene

Genomics for SEPT2 Gene

Regulatory Elements for SEPT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEPT2 Gene

Start:
241,315,100 bp from pter
End:
241,354,027 bp from pter
Size:
38,928 bases
Orientation:
Plus strand

Genomic View for SEPT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT2 Gene

Proteins for SEPT2 Gene

  • Protein details for SEPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15019-SEPT2_HUMAN
    Recommended name:
    Septin-2
    Protein Accession:
    Q15019
    Secondary Accessions:
    • B4DGE8
    • Q14132
    • Q53QU3
    • Q8IUK9
    • Q96CB0

    Protein attributes for SEPT2 Gene

    Size:
    361 amino acids
    Molecular mass:
    41487 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Interaction between SEPT2 and SEPT7 seems indirect. Interacts with SEPT5 (By similarity). Interaction with SEPT4 not detected (By similarity). Interacts with SEPT9. Interacts with MAP4.
    Miscellaneous:
    • Coordinated expression with SEPT6 and SEPT7
    SequenceCaution:
    • Sequence=AAY14718.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA09928.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEPT2 Gene

    Alternative splice isoforms for SEPT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT2 Gene

Proteomics data for SEPT2 Gene at MOPED

Post-translational modifications for SEPT2 Gene

  • Ubiquitination at Lys3, Lys116, Lys232, Lys275, Lys310, and Lys325
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEPT2 Gene

Domains for SEPT2 Gene

Gene Families for SEPT2 Gene

HGNC:

Protein Domains for SEPT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15019

UniProtKB/Swiss-Prot:

SEPT2_HUMAN :
  • Q15019
Domain:
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT2: view

No data available for Suggested Antigen Peptide Sequences for SEPT2 Gene

Function for SEPT2 Gene

Molecular function for SEPT2 Gene

UniProtKB/Swiss-Prot Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Gene Ontology (GO) - Molecular Function for SEPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10321247
GO:0005525 GTP binding IEA --
GO:0030234 enzyme regulator activity IEA --
GO:0032947 protein complex scaffold IEA --
genes like me logo Genes that share ontologies with SEPT2: view

Phenotypes for SEPT2 Gene

genes like me logo Genes that share phenotypes with SEPT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEPT2 Gene

Localization for SEPT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPT2 Gene COMPARTMENTS Subcellular localization image for SEPT2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SEPT2: view

Pathways for SEPT2 Gene

genes like me logo Genes that share pathways with SEPT2: view

Pathways by source for SEPT2 Gene

2 Qiagen pathways for SEPT2 Gene
1 BioSystems pathway for SEPT2 Gene
1 KEGG pathway for SEPT2 Gene

Gene Ontology (GO) - Biological Process for SEPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002036 regulation of L-glutamate transport IEA --
GO:0007049 cell cycle --
GO:0007067 mitotic nuclear division IEA --
GO:0007224 smoothened signaling pathway ISS --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with SEPT2: view

Transcripts for SEPT2 Gene

Unigene Clusters for SEPT2 Gene

Septin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9:
SP10:
SP11:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SEPT2 Gene

GeneLoc Exon Structure for
SEPT2
ECgene alternative splicing isoforms for
SEPT2

Expression for SEPT2 Gene

mRNA expression in normal human tissues for SEPT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT2 Gene

SOURCE GeneReport for Unigene cluster for SEPT2 Gene Hs.721234

mRNA Expression by UniProt/SwissProt for SEPT2 Gene

Q15019-SEPT2_HUMAN
Tissue specificity: Widely expressed. Up-regulated in liver cancer.
genes like me logo Genes that share expressions with SEPT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SEPT2 Gene

Orthologs for SEPT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPT2 35
  • 99.41 (n)
  • 99.75 (a)
SEPT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEPT2 35
  • 88.55 (n)
  • 97.78 (a)
SEPT2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPT2 35
  • 87.1 (n)
  • 94.29 (a)
SEPT2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sept2 35
  • 90.03 (n)
  • 98.61 (a)
Sept2 16
Sept2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPT2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sept2 35
  • 89.29 (n)
  • 98.06 (a)
chicken
(Gallus gallus)
Aves SEPT2 35
  • 82.05 (n)
  • 96.75 (a)
SEPT2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPT2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XlSeptA 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sept2 35
  • 79.23 (n)
  • 91.69 (a)
Str.10233 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5618 35
zebrafish
(Danio rerio)
Actinopterygii sept2 35
  • 75.95 (n)
  • 91.2 (a)
sept2 36
  • 77 (a)
OneToOne
wufb52g01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002645 35
  • 66.46 (n)
  • 75.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sep1 35
  • 66.06 (n)
  • 76.67 (a)
Sep1 36
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7975 36
  • 74 (a)
OneToOne
Species with no ortholog for SEPT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT2 Gene

ENSEMBL:
Gene Tree for SEPT2 (if available)
TreeFam:
Gene Tree for SEPT2 (if available)

Paralogs for SEPT2 Gene

Pseudogenes.org Pseudogenes for SEPT2 Gene

genes like me logo Genes that share paralogs with SEPT2: view

Variants for SEPT2 Gene

Sequence variations from dbSNP and Humsavar for SEPT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6672 -- 241,353,606(+) AAGCT(A/G/T)TATGT utr-variant-3-prime
rs7568 -- 241,352,328(+) GATTT(A/G)CCATA utr-variant-3-prime
rs8613 -- 241,353,954(+) AACAC(G/T)TATTT utr-variant-3-prime
rs9053 -- 241,353,883(+) AGATA(C/G)TTTTG utr-variant-3-prime
rs12078 -- 241,353,441(+) TGCTT(A/G)ATCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEPT2 Gene

Variant ID Type Subtype PubMed ID
esv2445970 CNV Deletion 19546169
esv2721993 CNV Deletion 23290073
esv2307098 CNV Deletion 18987734
esv3816 CNV Deletion 18987735
esv2721994 CNV Deletion 23290073
nsv876225 CNV Gain 21882294

Relevant External Links for SEPT2 Gene

HapMap Linkage Disequilibrium report
SEPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT2 Gene

Disorders for SEPT2 Gene

(1) Novoseek inferred disease relationships for SEPT2 Gene

Disease -log(P) Hits PubMed IDs
leukemia 23.1 1

Relevant External Links for SEPT2

Genetic Association Database (GAD)
SEPT2
Human Genome Epidemiology (HuGE) Navigator
SEPT2
genes like me logo Genes that share disorders with SEPT2: view

No data available for UniProtKB/Swiss-Prot for SEPT2 Gene

Publications for SEPT2 Gene

  1. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. (PMID: 15150837) She Y.M. … Trimble W.S. (Rapid Commun. Mass Spectrom. 2004) 3 4 23
  2. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. (PMID: 8697812) Mori T. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4
  3. Structural analysis of septin 2, 6, and 7 complexes. (PMID: 16914550) Low C. … Macara I.G. (J. Biol. Chem. 2006) 3 4 23
  4. The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation. (PMID: 19165576) Yu W. … Yu L. (Mol. Cell. Biochem. 2009) 3 4 23
  5. The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. (PMID: 12388755) Surka M.C. … Trimble W.S. (Mol. Biol. Cell 2002) 3 23

Products for SEPT2 Gene

  • Addgene plasmids for SEPT2

Sources for SEPT2 Gene

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