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SEPT2 Gene

protein-coding   GIFtS: 55
GCID: GC02P242254

Septin 2

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
(Previous symbols: DIFF6, NEDD5)
  Search for SEPT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Septin 21 2     NEDD-52 3
DIFF61 2 3 5     Pnutl32
NEDD51 2 3 5     hNedd52
Neural Precursor Cell Expressed, Developmentally Down-Regulated 51 2     septin-22
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 52 3     KIAA01583

External Ids:    HGNC: 77291   Entrez Gene: 47352   Ensembl: ENSG000001683857   OMIM: 6015065   UniProtKB: Q150193   

Export aliases for SEPT2 gene to outside databases

Previous GC identifers: GC02P241975 GC02P234010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEPT2 Gene:
SEPT2 (septin 2) is a protein-coding gene. GO annotations related to this gene include enzyme regulator activity and GTP binding. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019
Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays
a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules,
thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the
progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE
localization at kinetochores and consequently chromosome congression. During anaphase, may be required for
chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In
cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents
diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the
assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in
the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri

Gene Wiki entry for SEPT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SEPT2 gene promoter:
         Nkx3-1 v2   Nkx3-1   Max1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   Cdc5   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEPT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

SEPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242254:  view genomic region     (about GC identifiers)

Start:
242,254,515 bp from pter      End:
242,293,442 bp from pter
Size:
38,928 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019 (See protein sequence)
Recommended Name: Septin-2  
Size: 361 amino acids; 41487 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation.
Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate
head-to-head to form a hexameric unit. Interaction between SEPT2 and SEPT7 seems indirect. Interacts with SEPT5
(By similarity). Interaction with SEPT4 not detected (By similarity). Interacts with SEPT9. Interacts with MAP4
Miscellaneous: Coordinated expression with SEPT6 and SEPT7
Sequence caution: Sequence=AAY14718.1; Type=Erroneous gene model prediction; Sequence=BAA09928.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for SEPT2:
2QA5 (3D)        2QAG (3D)        2QNR (3D)    
Secondary accessions: B4DGE8 Q14132 Q53QU3 Q8IUK9 Q96CB0
Alternative splicing: 2 isoforms:  Q15019-1   Q15019-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEPT2: NX_Q15019

Explore proteomics data for SEPT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys3, Lys116, Lys232, Lys275, Lys310, Lys325
  • Modification sites at PhosphoSitePlus

  • See SEPT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001008491.1  NP_001008492.1  NP_001269901.1  NP_001269902.1  NP_004395.1  NP_006146.1  

    ENSEMBL proteins: 
     ENSP00000375834   ENSP00000397195   ENSP00000353157   ENSP00000389174   ENSP00000404484  
     ENSP00000386001   ENSP00000375832   ENSP00000385109   ENSP00000384525   ENSP00000397290  
     ENSP00000406181   ENSP00000394666   ENSP00000399767   ENSP00000385172   ENSP00000413031  
     ENSP00000403287   ENSP00000399195   ENSP00000412434   ENSP00000404417   ENSP00000409596  
     ENSP00000391717   ENSP00000408902   ENSP00000408296   ENSP00000402256  

    SEPT2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SEPT2 

    SEPT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SEPT2
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    Search for Antibodies for SEPT2 at Abcam
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    ThermoFisher Antibodies for SEPT2
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    SEPT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for SEPT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEPT: Septins

    4 InterPro protein domains:
     IPR008113 Septin2
     IPR016491 Septin
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15019

    ProtoNet protein and cluster: Q15019

    2 Blocks protein domains:
    IPB000038 Cell division/GTP binding protein
    IPB008113 Septin 2 signature


    UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019
    Similarity: Belongs to the septin family


    Find genes that share domains with SEPT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPT2_HUMAN, Q15019
    Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays
    a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules,
    thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the
    progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE
    localization at kinetochores and consequently chromosome congression. During anaphase, may be required for
    chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In
    cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents
    diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the
    assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in
    the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10321247
    GO:0005525GTP binding IEA--
    GO:0030234enzyme regulator activity IEA--
    GO:0032947protein complex scaffold IEA--
         
    Find genes that share ontologies with SEPT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEPT2:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEPT2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEPT2:
    hsa-mir-106a-5p (MIRT048333), hsa-mir-20a-5p (MIRT050517), hsa-mir-421 (MIRT039399), hsa-mir-15b-5p (MIRT046451), hsa-mir-124-3p (MIRT022377), hsa-mir-23a-3p (MIRT050437), hsa-mir-373-3p (MIRT004515), hsa-mir-652-3p (MIRT039504), hsa-mir-17-5p (MIRT050919), hsa-mir-877-3p (MIRT036930), hsa-mir-615-3p (MIRT040241), hsa-mir-744-5p (MIRT037693)

    Block miRNA regulation of human, mouse, rat SEPT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPT2 (see all 42):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-607 hsa-miR-4307 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SEPT2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SEPT2 (see all 20)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT2
    Addgene plasmids for SEPT2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEPT2_HUMAN, Q15019: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome,
    centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane (By
    similarity). Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close
    apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the
    midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar
    shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with
    polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus.
    Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    plasma membrane4
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with SEPT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPT2 About    
    See pathways by source

    SuperPathContained pathways About
    1CDC42 signaling events
    CDC42 signaling events0.34
    2Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells


    Find genes that share SuperPaths with SEPT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SEPT2
        RhoA Pathway
    Rho Family GTPases

    1 BioSystems Pathway for SEPT2
        CDC42 signaling events



    1 Kegg Pathway  (Kegg details for SEPT2):
        Bacterial invasion of epithelial cells

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEPT2
    Interactions:

        GeneGlobe Interaction Network for SEPT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEPT2 (Q150191, 2, 3 ENSP000003531574) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT6Q141411, 3, ENSP000003415244EBI-741220,EBI-745901 I2D: score=6 STRING: ENSP00000341524
    PIK3R1P279862, 3, ENSP000002743354MINT-3378272 I2D: score=2 STRING: ENSP00000274335
    STMN1P169492, 3, ENSP000004104524MINT-8270132 I2D: score=2 STRING: ENSP00000410452
    CRAMP1LQ96RY52, 3, ENSP000002939254MINT-8270121 I2D: score=1 STRING: ENSP00000293925
    COG4Q9H9E32, 3, ENSP000003157754MINT-8270099 I2D: score=2 STRING: ENSP00000315775
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002036regulation of L-glutamate transport IEA--
    GO:0007049cell cycle ----
    GO:0007067mitosis IEA--
    GO:0007224smoothened signaling pathway ISS--
    GO:0007264small GTPase mediated signal transduction ----

    Find genes that share ontologies with SEPT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEPT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEPT2 gene (6 alternative transcripts): 
    NM_001008491.2  NM_001008492.2  NM_001282972.1  NM_001282973.1  NM_004404.4  NM_006155.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 44):
    ENST00000391973 ENST00000492978 ENST00000428282 ENST00000360051(uc002wbc.3 uc002wbd.3)
    ENST00000428524 ENST00000445030 ENST00000407017 ENST00000469434 ENST00000495463
    ENST00000391971(uc002wbg.3 uc002wbh.3 uc010zop.2) ENST00000482304
    ENST00000475474 ENST00000469175 ENST00000401990 ENST00000407971 ENST00000461048(uc002wbe.1)
    ENST00000457335 ENST00000436795
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    hsa-miR-140-5p hsa-miR-520f hsa-miR-607 hsa-miR-4307 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p
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      QuantiFast Probe-based Assays in human, mouse, rat SEPT2

    Selected AceView cDNA sequences (see all 1255):

    BQ672253 BM663276 AW771795 AA516108 BX385451 BM688939 BF433814 BE044063 
    AA482233 BM748944 AA487437 N67234 T36137 AI201560 AW473653 AA581140 
    AA382246 AA027988 AI624808 AI032853 BF477182 AA565842 T35389 CR625560 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEPT2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a ·
    SP1:                                                  -     -     -                 -                                                                           
    SP2:                                                                                                                                            -     -     -   
    SP3:                          -     -     -           -     -     -                 -                                                                           
    SP4:                                                  -     -     -                 -                                                                           
    SP5:        -     -     -     -     -                 -     -                       -                                                                           

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SEPT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGAGTCCAT
    SEPT2 Expression
    About this image


    SEPT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SEPT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPT2 Protein Expression

    UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019
    Tissue specificity: Widely expressed. Up-regulated in liver cancer

        Custom PCR Arrays for SEPT2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SEPT2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sept21 , 5 septin 21, 5 90.03(n)1
    98.61(a)1
      1 (47.24 cM)5
    180001  NM_001159719.11  NP_001153191.11 
     934789645 
    chicken
    (Gallus gallus)
    Aves SEPT21 septin 2 82.05(n)
    96.75(a)
      424843  XM_422654.4  XP_422654.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPT26
    septin 2
    93(a)
    1 ↔ 1
    3(30289791-30298714)
    African clawed frog
    (Xenopus laevis)
    Amphibia XlSeptA2 septin A 77.56(n)    AF212298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb52g012 Danio rerio cDNA clone IMAGE2640115, partial cds 82.48(n)    BC055230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sep11 Septin 1 66.06(n)
    76.67(a)
      33114  NM_078706.3  NP_523430.1 


    ENSEMBL Gene Tree for SEPT2 (if available)
    TreeFam Gene Tree for SEPT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPT2 gene
    SEPT32  SEPT92  SEPT142  SEPT42  SEPT12  SEPT122  SEPT72  ENSG000002704662  
    SEPT62  SEPT112  SEPT102  SEPT82  SEPT52  
    Selected SIMAP similar genes for SEPT2 using alignment to 19 protein entries:     SEPT2_HUMAN (see all proteins) (see all similar genes):
    SEPT4    SEPT1    SEPT5    SEPT7    COL24A1    Nbla02942
    DKFZp686F17268    BTBD2    CTSS    ERBB2    SEPT9    USP10
    SEPT3    CFLAR    FAM3A    HKR1    ZNF212    ZNF547

    Find genes that share paralogs with SEPT2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SEPT2
    PGOHUM00000244828 PGOHUM00000250865


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPT2 (see all 836)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010687711,2
    --242257163(+) ATGGA-/CCTTCC 4 -- int10--------
    rs1476415191,2
    --242257167(+) ACCTT-/CCGGG 
            
    TTCTA
    4 -- int10--------
    rs2017546391,2
    --242257167(+) ACCTT-/CCGG  
            
    GTTCT
    4 -- int10--------
    rs102008901,2
    C,F,H--242257358(+) TTTTGA/GTCCAA 4 -- int129Minor allele frequency- G:0.23NS EA NA WA CSA 2642
    rs1919835481,2
    --242257363(+) GTCCAA/GTTTGC 4 -- int10--------
    rs1163135191,2
    --242257426(+) GGCTTC/TCTCAC 4 -- int10--------
    rs1840058951,2
    --242257471(+) CTTTCA/CCCTTC 4 -- int10--------
    rs134126491,2
    H--242257528(+) AAGTTA/TTGTTT 4 -- int14Minor allele frequency- T:0.00NS EA 416
    rs571171941,2
    C--242257552(+) AAAAA-/AGATGG 4 -- int10--------
    rs800861611,2
    --242257552(+) ACAGGG/AAAAAA 4 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SEPT2 (242254515 - 242293442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SEPT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721994CNV Deletion23290073
    esv2307098CNV Deletion18987734
    esv2445970CNV Deletion19546169
    esv2721993CNV Deletion23290073
    esv3816CNV Deletion18987735
    nsv876225CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601506    OMIM disorders: --


    Find genes that share disorders with SEPT2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SEPT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 23.1 1 19445675 (1)

    Genetic Association Database (GAD): SEPT2
    Human Genome Epidemiology (HuGE) Navigator: SEPT2 (4 documents)

    Export disorders for SEPT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPT2 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with SEPT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. (PubMed id 8697812)1, 2, 3 Mori T.... Nakamura Y. (Cytogenet. Cell Genet. 1996)
    2. The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation. (PubMed id 19165576)1, 2, 9 Yu W.... Yu L. (Mol. Cell. Biochem. 2009)
    3. Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. (PubMed id 15150837)1, 2, 9 She Y.M.... Trimble W.S. (Rapid Commun. Mass Spectrom. 2004)
    4. Structural analysis of septin 2, 6, and 7 complexes. (PubMed id 16914550)1, 2, 9 Low C. and Macara I.G. (J. Biol. Chem. 2006)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    8. Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. (PubMed id 18209106)1, 2 Spiliotis E.T.... Nelson W.J. (J. Cell Biol. 2008)
    9. Structural insight into filament formation by mammalian septins. (PubMed id 17637674)1, 2 Sirajuddin M.... Wittinghofer A. (Nature 2007)
    10. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2 Kremer B.E.... Macara I.G. (Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4735 HGNC: 7729 AceView: NEDD5 Ensembl:ENSG00000168385 euGenes: HUgn4735
    ECgene: SEPT2 Kegg: 4735 H-InvDB: SEPT2

    (According to HUGE)
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    HUGE: KIAA0158

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPT2 gene:
    Search GeneIP for patents involving SEPT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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