SEPT2 Gene
protein-coding GIFtS: 55
GCID: GC02P242254
|
|
septin 2(Previous names: neural precursor cell expressed, developmentally down-regulated...)
(Previous symbols: DIFF6, NEDD5)
| |
Aliases
for SEPT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Septin 21 2 | | Neural Precursor Cell Expressed, Developmentally Down-Regulated 51 2 | | DIFF61 2 3 5 | | KIAA01581 3 | | NEDD51 2 3 5 | | Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 52 3 | | Pnutl31 2 | | NEDD-52 3 | | HNedd51 | | Septin-21 |
Export aliases for SEPT2 gene to outside databasesPrevious GC identifers: GC02P241975 GC02P234010 |
Summaries
for SEPT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays arole in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thusfacilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progressionthrough mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization atkinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation andspindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrityof the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins betweenthe cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens,Listeria monocytogenes and Shigella flexneri
Gene Wiki entry for SEPT2
|
Genomic Views
for SEPT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEPT2 gene promoter:
Nkx3-1 v2 Nkx3-1 Max1 Nkx3-1 v4 Nkx3-1 v3 Nkx3-1 v1 Cdc5 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEPT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3SEPT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P242254: view genomic region
(about GC identifiers)
Start:
|
242,254,515 bp from pter |
End:
|
242,293,442 bp from pter |
Size:
|
38,928 bases |
Orientation:
|
plus strand |
|
Proteins
for SEPT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019 (See
protein sequence)Recommended Name: Septin-2 Size: 361 amino acids; 41487 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellularmembranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments areassembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form ahexameric unit. Interaction between SEPT2 and SEPT7 seems indirect. Interacts with SEPT5 (By similarity). Interactionwith SEPT4 not detected (By similarity). Interacts with SEPT9. Interacts with MAP4
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere,kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane (By similarity).Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to thekinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressingcleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actinat the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around thetrans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near themorphological distinction between the cilia and plasma membranes
Miscellaneous: Coordinated expression with SEPT6 and SEPT7
Sequence caution: Sequence=AAY14718.1; Type=Erroneous gene model prediction; Sequence=BAA09928.2; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from  and Proteopedia  for SEPT2:2QA5 (3D)
2QAG (3D)
2QNR (3D)
Secondary accessions: B4DGE8 Q14132 Q53QU3 Q8IUK9 Q96CB0Alternative splicing: 2 isoforms: Q15019-1 Q15019-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEPT2: NX_Q15019
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15019
SEPT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001008491.1 NP_001008492.1 NP_004395.1 NP_006146.1
ENSEMBL proteins: ENSP00000375834 ENSP00000397195 ENSP00000353157 ENSP00000389174 ENSP00000404484 ENSP00000386001 ENSP00000375832 ENSP00000385109 ENSP00000384525 ENSP00000397290 ENSP00000406181 ENSP00000394666 ENSP00000399767 ENSP00000385172 ENSP00000413031 ENSP00000403287 ENSP00000399195 ENSP00000412434 ENSP00000404417 ENSP00000409596 ENSP00000391717 ENSP00000408902 ENSP00000408296 ENSP00000402256
Human Recombinant Protein Products:
Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18): About this table
SEPT2 for ontologies About GeneDecksing
SEPT2 Antibody Products:
Assay Products for SEPT2: |
Protein
Domains /
Families
for SEPT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEPT2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15019ProtoNet protein and cluster: Q15019 2 Blocks protein families: IPB000038 Cell division/GTP binding protein IPB008113 Septin 2 signature
UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019Similarity: Belongs to the septin family |
Function
for SEPT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays arole in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thusfacilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progressionthrough mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization atkinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation andspindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrityof the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins betweenthe cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens,Listeria monocytogenes and Shigella flexneri
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SEPT2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SEPT2:
|
Pathways & Interactions
for SEPT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RAC1 in cellular process | |
1  BioSystems Pathway for SEPT2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEPT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/60 Interacting proteins for SEPT2 (Q150191, 2, 3 ENSP000003531574) via UniProtKB, MINT, STRING, and/or I2D (see all 60)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SEPT6 | Q141411, 3, ENSP000003415244 | EBI-741220,EBI-1047521 I2D:
score=6 STRING: ENSP00000341524 | | PIK3R1 | P279862, 3, ENSP000002743354 | MINT-3378272 I2D:
score=2 STRING: ENSP00000274335 | | STMN1 | P169492, 3, ENSP000004104524 | MINT-8270132 I2D:
score=2 STRING: ENSP00000410452 | | CRAMP1L | Q96RY52, 3, ENSP000002939254 | MINT-8270121 I2D:
score=1 STRING: ENSP00000293925 | | COG4 | Q9H9E32, 3, ENSP000003157754 | MINT-8270099 I2D:
score=2 STRING: ENSP00000315775 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
SEPT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEPT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEPT2
Search CenterWatch for drugs/clinical trials and news about SEPT2
|
Transcripts
for SEPT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEPT2 gene (4 alternative transcripts): NM_001008491.1 NM_001008492.1 NM_004404.3 NM_006155.1 Unigene Cluster for SEPT2: Septin 2 Hs.721234 [show with all ESTs]Unigene Representative Sequence: NM_00100849118/44 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 44): ENST00000391973 ENST00000492978 ENST00000428282 ENST00000360051(uc002wbc.3 uc002wbd.3)
ENST00000428524 ENST00000445030 ENST00000407017 ENST00000469434 ENST00000495463
ENST00000391971(uc002wbg.3 uc002wbh.3 uc010zop.2) ENST00000482304
ENST00000475474 ENST00000469175 ENST00000401990 ENST00000407971 ENST00000461048(uc002wbe.1)
ENST00000457335 ENST00000436795
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SEPT2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEPT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT2 |
Additional cDNA sequence: AF038404.1 AK025163.1 AK294563.1 BC014455.1 BC033559.1 BC040676.1 BC043180.1 BX648000.1 D28540.1 D63878.1 24/83 DOTS entries (see all 83): DT.100033375 DT.91773953 DT.100684920 DT.91915294 DT.91959159 DT.100684911 DT.87012262 DT.91773966 DT.91773947 DT.100684906 DT.92413358 DT.120964381 DT.100684915 DT.100684922 DT.100684905 DT.87017681 DT.75172050 DT.120964489 DT.100684916 DT.100847908 DT.91773961 DT.100684914 DT.95272772 DT.91727308 24/1255 AceView cDNA sequences (see all 1255): AU135728 H88277 AA605199 AA722660 CA450445 AI074412 AI201433 AI951387 AW169354 AW469297 AI580723 H98472 T35991 AA887871 CA418289 AI355732 BU742526 CR620550 AA182579 AI083951 BU520984 BX456310 AU129755 AI242041
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT2 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | |
| SP3: | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for SEPT2
|
Expression
for SEPT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEPT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAGTCCAT
About this image
See SEPT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEPT2
SOURCE GeneReport for Unigene cluster: Hs.721234
UniProtKB/Swiss-Prot: SEPT2_HUMAN, Q15019Tissue specificity: Widely expressed. Up-regulated in liver cancer
SABiosciences Custom PCR Arrays for SEPT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT2 |
Orthologs
for SEPT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SEPT2 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SEPT21 |
septin 2 |
81.63(n)
95.29(a) |
|
424843 XM_422654.3 XP_422654.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SEPT26 |
-- |
93(a) |
1 ↔ 1 |
3(30289791-30298714) |
African clawed frog
(Xenopus laevis) |
Amphibia |
XlSeptA2 |
septin A |
77.56(n) |
|
AF212298.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb52g012 |
Danio rerio cDNA clone IMAGE2640115, partial cds |
82.48(n) |
|
BC055230.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sep11 |
Septin-1 |
66.37(n)
76.63(a) |
|
33114 NM_078706.3 NP_523430.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-596 |
UNCoordinated family member (unc-59) |
33(a) |
possible ortholog |
I(13629214-13633485) |
ENSEMBL Gene Tree for SEPT2 (if available)
TreeFam Gene Tree for SEPT2 (if available) |
Paralogs
for SEPT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEPT2 gene
- SEPT32 SEPT92 SEPT142 SEPT42 SEPT12 SEPT72 SEPT122 SEPT62
- SEPT7L2 SEPT112 SEPT102 SEPT82 SEPT52
18/78 SIMAP similar genes for SEPT2 using alignment to 19 protein entries: SEPT2_HUMAN (see all proteins)
(see all similar genes):NXPE2 SEPT4 SEPT1 SEPT5 SEPT7 COL24A1
Nbla02942 DKFZp686F17268 BTBD2 ERBB2 SEPT9 USP10
SEPT3 CFLAR FAM3A HKR1 ZNF212 ZNF585B
SEPT2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SEPT2
PGOHUM00000244828 PGOHUM00000250865
|
Genomic Variants
for SEPT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEPT2 (242254515 - 242293442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SEPT2
1 CNV: 98192
3 Indels: 42131 40433 45984 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SEPT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SEPT2 for disorders About MalaCards
SEPT2 for disorders About GeneDecksing
OMIM gene information: 601506
OMIM disorders: --
1 Novoseek disease relationship for SEPT2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
23.1 |
1 |
19445675 (1) |
Human Genome Epidemiology (HuGE) Navigator: SEPT2 (4 documents)
Export disorders for SEPT2 gene to outside databases
|
Publications
for SEPT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEPT2 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with SEPT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. (PubMed id 8697812)1, 2, 3 Mori T.... Nakamura Y. (1996)
- The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation. (PubMed id 19165576)1, 2, 9 Yu W.... Yu L. (2009)
- Septin 2 phosphorylation: theoretical and mass spectrometric evidence for the existence of a single phosphorylation site in vivo. (PubMed id 15150837)1, 2, 9 She Y.M.... Trimble W.S. (2004)
- Structural analysis of septin 2, 6, and 7 complexes. (PubMed id 16914550)1, 2, 9 Low C. and Macara I.G. (2006)
- Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. (PubMed id 18209106)1, 2 Spiliotis E.T.... Nelson W.J. (2008)
- Structural insight into filament formation by mammalian septins. (PubMed id 17637674)1, 2 Sirajuddin M.... Wittinghofer A. (2007)
- Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PubMed id 17803907)1, 2 Kremer B.E.... Macara I.G. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A mitotic septin scaffold required for mammalian chromosome congression and segregation. (PubMed id 15774761)1, 2 Spiliotis E.T.... Nelson W.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
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External Searches for SEPT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SEPT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SEPT2 gene
(According to HUGE)
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Specialized Databases showing SEPT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for SEPT2 gene:
Search GeneIP for patents involving SEPT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SEPT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SEPT2 | | OriGene shRNA RFP for SEPT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT2 | | | OriGene Protein Over-expression Lysate for SEPT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEPT2 | | OriGene 3'-UTR Clone for SEPT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SEPT2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SEPT2 | | OriGene Custom Protein Services for SEPT2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEPT2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT2 |
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| | | | Search Tocris compounds for SEPT2 |
| |  |  |  |  | | | | | | Recombinant Protein for SEPT2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT2 |
|  |  |  | | | | ThermoFisher Antibodies for SEPT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT2 |
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