SEPT14 Gene
protein-coding GIFtS: 38
GCID: GC07M055829
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septin 14
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Aliases
for SEPT14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Septin 141 2 | | FLJ440601 | | Septin-141 |
Export aliases for SEPT14 gene to outside databasesPrevious GC identifer: GC07M055675 |
Summaries
for SEPT14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEPT14:
SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membranetransport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson etal., 2007 (PubMed 17922164)).(supplied by OMIM, Jul 2008)
UniProtKB/Swiss-Prot: SEP14_HUMAN, Q6ZU15Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)
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Genomic Views
for SEPT14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_033968.6 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEPT14 gene promoter:
MAZR LCR-F1 C/EBPalpha HNF-1A Evi-1 HEN1 AREB6 HNF-1 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEPT14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p11.2 Ensembl cytogenetic band: 7p11.2 HGNC cytogenetic band: 7p11.2SEPT14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M055829: view genomic region
(about GC identifiers)
Start:
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55,861,237 bp from pter |
End:
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55,930,482 bp from pter |
Size:
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69,246 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 55,865,484-55,934,729 |
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Proteins
for SEPT14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEP14_HUMAN, Q6ZU15 (See
protein sequence)Recommended Name: Septin-14 Size: 432 amino acids; 50025 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate withcellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (Bysimilarity). Interacts with SEPT9
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers
Sequence caution: Sequence=BAC86412.1; Type=Erroneous initiation;
Secondary accessions: A6NCC2 B4DXD6Explore the universe of human proteins at neXtProt for SEPT14: NX_Q6ZU15
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZU15
SEPT14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997249.2
ENSEMBL proteins: ENSP00000373627
Human Recombinant Protein Products for SEPT14:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031105 | septin complex |
IEA | -- |
SEPT14 for ontologies About GeneDecksing
SEPT14 Antibody Products:
Assay Products for SEPT14: |
Protein
Domains /
Families
for SEPT14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEPT14 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZU15ProtoNet protein and cluster: Q6ZU15 UniProtKB/Swiss-Prot: SEP14_HUMAN, Q6ZU15Similarity: Belongs to the septin family |
Function
for SEPT14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SEP14_HUMAN, Q6ZU15Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SEPT14 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SEPT14:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SEPT14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT14 |
|
Pathways & Interactions
for SEPT14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPT14
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for SEPT14 (Q6ZU151, 3 ENSP000003736274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SEPT14 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEPT14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEPT14
Search CenterWatch for drugs/clinical trials and news about SEPT14 / SEP14
|
Transcripts
for SEPT14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEPT14 gene: NM_207366.2 Unigene Cluster for SEPT14: Septin 14 Hs.453629 [show with all ESTs]Unigene Representative Sequence: NM_2073662 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000388975(uc003tqz.2) ENST00000477628
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SEPT14 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEPT14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT14 |
Additional cDNA sequence: AK126048.1 AK301928.1 2 DOTS entries: DT.75101491 DT.75106882 16 AceView cDNA sequences: AI423645 AI422945 AI337138 AI424090 BF594223 AL041479 AL041480 AI422017 NM_207366 AI363249 AK126048 AI423113 AI359637 AI423279 AI420795 BF196657
GeneLoc Exon Structure
|
Expression
for SEPT14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEPT14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGTTTTA
About this image
See SEPT14 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.453629
UniProtKB/Swiss-Prot: SEP14_HUMAN, Q6ZU15Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for SEPT14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT14 |
Orthologs
for SEPT14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SEPT14 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for SEPT14 (if available)
TreeFam Gene Tree for SEPT14 (if available) |
Paralogs
for SEPT14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEPT14 gene
- SEPT32 SEPT92 SEPT42 SEPT12 SEPT72 SEPT122 SEPT62 SEPT7L2
- SEPT112 SEPT22 SEPT102 SEPT82 SEPT52
17 SIMAP similar genes for SEPT14 using alignment to 1 protein entry: SEP14_HUMAN:DKFZp547B243 SEPT11 SEPT10 SEPT8 SEPT6 DKFZp564M1416
SEPT7L SEPT3 SEPT4 SEPT7 SEPT1 DKFZp686F17268
Nbla02942 SEPT12 SEPT9 SEPT5 SEPT2
SEPT14 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for SEPT14 (see all 7)
PGOHUM00000244383 PGOHUM00000259615 PGOHUM00000259886 PGOHUM00000259953 PGOHUM00000260225
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Genomic Variants
for SEPT14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEPT14 (55861237 - 55930482 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEPT14
1 CNV: 64828
1 Indel: 40981 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPT14 |
|
Disorders
/ Diseases
for SEPT14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SEPT14 for disorders About MalaCards
SEPT14 for disorders About GeneDecksing
OMIM gene information: 612140
OMIM disorders: --
Export disorders for SEPT14 gene to outside databases
|
Publications
for SEPT14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEPT14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SEPT14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. (PubMed id 17922164)1, 2 Peterson E.A....Petty E.M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
|
External Searches for SEPT14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEPT14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEPT14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEPT14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEPT14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEPT14 gene:
Search GeneIP for patents involving SEPT14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEPT14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SEPT14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT14 | | | OriGene Protein Over-expression Lysate for SEPT14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEPT14 | | OriGene 3'-UTR Clone for SEPT14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SEPT14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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