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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEPT12 Gene

protein-coding GIFtS: 44
GCID: GC16M004829

septin 12

Search for SEPT12
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Septin 12¹ ²
FLJ25410¹
SPGF10²
Septin-12¹

External Ids:	HGNC: 26348¹	Entrez Gene: 124404²	Ensembl: ENSG00000140623⁷	OMIM: 611562⁵	UniProtKB: Q8IYM1³

Export aliases for SEPT12 gene to outside databases

Previous GC identifer: GC16M004768

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT12:

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins

play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEPT12 gene promoter:
COUP-TF1 COUP HNF-4alpha1 E47 PPAR-gamma1 COUP-TF FOXO4 Hand1 PPAR-gamma2 MRF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SEPT12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

SEPT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT12 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M004829: view genomic region (about GC identifiers)

Start:	4,827,670 bp from pter	End:	4,838,522 bp from pter
Size:	10,853 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1 (See protein sequence)

Recommended Name: Septin-12

Size: 358 amino acids; 40748 Da

Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with

cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By

similarity). Interacts with SEPT6 and SEPT11. Forms homodimers

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium,

flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the

central spindle region and to the midbody during cytokinesis. Found in the sperm annulus

Sequence caution: Sequence=AAH24017.1; Type=Erroneous initiation;

Secondary accessions: Q0P6B0 Q1PBH0 Q96LL0

Alternative splicing: 2 isoforms: Q8IYM1-1 Q8IYM1-2

Explore the universe of human proteins at neXtProt for SEPT12: NX_Q8IYM1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYM1

SEPT12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001147930.1 NP_653206.2

ENSEMBL proteins:

ENSP00000464775 ENSP00000379922 ENSP00000268231 ENSP00000467237 ENSP00000468601

ENSP00000467281

Human Recombinant Protein Products:

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	OriGene Purified Protein: SEPT12 OriGene Protein Over-expression Lysate (see all 2): SEPT12 OriGene Custom Protein Services for SEPT12
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	Novus Biologicals SEPT12 Proteins Novus Biologicals SEPT12 Lysates
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	ISS	--
GO:0005819	spindle	IDA	18047794
GO:0005929	cilium	--	--
GO:0015630	microtubule cytoskeleton	IDA	--
GO:0030496	midbody	IDA	18047794

SEPT12 for ontologies About GeneDecksing

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Assay Products for SEPT12:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEPT12 for domains About GeneDecksing

2 InterPro domains/families:

IPR000038 Cell_div_GTP-bd

IPR016491 Septin

Graphical View of Domain Structure for InterPro Entry Q8IYM1

ProtoNet protein and cluster: Q8IYM1

1 Blocks protein family: IPB000038 Cell division/GTP binding protein

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Similarity: Belongs to the septin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT12
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SEPT12:
		hsa-miR-330-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT12 OriGene shRNA RFP: SEPT12 OriGene siRNA: SEPT12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEPT12

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEPT12
		Search LifeMap BioReagents cell lines for SEPT12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18047794
GO:0005525	GTP binding	ISS	--
GO:0019003	GDP binding	ISS	--
GO:0035091	phosphatidylinositol binding	ISS	--
GO:0042803	protein homodimerization activity	ISS	--

SEPT12 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Sept12^tm1.1Plk for SEPT12
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sept12):

cellular

endocrine/exocrine gland

reproductive system

SEPT12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEPT12

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for SEPT12 (Q8IYM1^{1, 3} ENSP00000268231⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT6	Q14141¹^,³, ENSP00000341524⁴	EBI-2585067,EBI-1047521 I2D: score=1 STRING: ENSP00000341524
SEPT1	ENSP00000324511⁴	STRING: ENSP00000324511
SEPT10	ENSP00000380824⁴	STRING: ENSP00000380824
SEPT11	ENSP00000264893⁴	STRING: ENSP00000264893
SEPT14	ENSP00000373627⁴	STRING: ENSP00000373627

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0051301	cell division	IEA	--

SEPT12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEPT12
Search CenterWatch for drugs/clinical trials and news about SEPT12 / SEP12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEPT12 gene (2 alternative transcripts):

NM_001154458.2 NM_144605.4

Unigene Cluster for SEPT12:

Septin 12

Hs.126780 [show with all ESTs]

Unigene Representative Sequence: EF620906

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588241 ENST00000396693(uc002cxq.3 uc002cxr.3 uc010bty.3)

ENST00000268231 ENST00000587603 ENST00000590741 ENST00000591861 ENST00000590303

ENST00000591624

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT12
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SEPT12:
		hsa-miR-330-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT12 OriGene shRNA RFP: SEPT12 OriGene siRNA: SEPT12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT12 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT12 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for SEPT12
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEPT12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT12

Additional cDNA sequence:

AK058139.1 AK098718.1 BC024017.1 BC035619.1 DQ456996.1 DQ517531.1 EF620906.1

3 DOTS entries:

DT.95367332 DT.97807255 DT.120686226

24/27 AceView cDNA sequences (see all 27):

AI554914 AA382830 BC035619 BI829633 AI393577 AI797580 BC024017 BI830976

AK098718 BI830266 NM_144605 AA913452 BI520378 AK058139 AI018797 BG719750

BI832349 BP370735 AW137847 BM564067 AI890919 AA448485 BF222811 AI809012

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT12 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12
SP1:					-				-						-								-
SP2:					-				-						-
SP3:					-				-
SP4:															-
SP5:

ECgene alternative splicing isoforms for SEPT12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEPT12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGATTCTGA

About this image

SEPT12 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Intermediate Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

See SEPT12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEPT12

SOURCE GeneReport for Unigene cluster: Hs.126780

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SEPT12

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEPT12 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEPT12¹	septin 12	74.71(n) 71.79(a)		416408 XM_003642160.1 XP_003642208.1
lizard (Anolis carolinensis)	Reptilia	SEPT12⁶	--	67(a)	1 ↔ 1	GL343811.1(3758-52400)
African clawed frog (Xenopus laevis)	Amphibia	BC057732.1²	--	76.05(n)		BC057732.1
zebrafish (Danio rerio)	Actinopterygii	wu:fe23c11¹	wu:fe23c11	66.88(n) 66.99(a)		564600 XM_687930.3 XP_693022.3
worm (Caenorhabditis elegans)	Secernentea	unc-59⁶	UNCoordinated family member (unc-59)	26(a)	possible ortholog	I(13629214-13633485)

ENSEMBL Gene Tree for SEPT12 (if available)
TreeFam Gene Tree for SEPT12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEPT12 gene

SEPT3² SEPT9² SEPT14² SEPT4² SEPT1² SEPT7² SEPT6² SEPT7L²

SEPT11² SEPT2² SEPT10² SEPT8² SEPT5²

15 SIMAP similar genes for SEPT12 using alignment to 6 protein entries: SEP12_HUMAN (see all proteins):

SEPT3 SEPT9 SEPT7L SEPT1 Nbla02942 SEPT7

SEPT2 DKFZp686F17268 SEPT4 SEPT5 SEPT11 SEPT8

SEPT6 SEPT14 SEPT10

SEPT12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190653006^1,2		--	4827193(+)	`AACCCA/GGGAGG`	2	--	ds500¹		0	--	--	--	--
rs8054401^1,2	C,F,A,H,	--	4827211(+)	`TGTAGT/CGAGCC`	2	--	ds500¹		8		NA WA CSA	15
rs182467234^1,2		--	4827231(+)	`CCATCA/GCACTC`	2	--	ds500¹		0	--	--	--	--
rs144745169^1,2		--	4827255(+)	`AAGAGC/TGAAAC`	2	--	ds500¹		0	--	--	--	--
rs146729955^1,2		--	4827289(+)	`ACAAAA/CAAAAA`	2	--	ds500¹		0	--	--	--	--
rs148845681^1,2		--	4827290(+)	`CAAAAA/CAAAAA`	2	--	ds500¹		0	--	--	--	--
rs187107836^1,2		--	4827346(+)	`ACAAAA/CACATA`	2	--	ds500¹		0	--	--	--	--
rs73513244^1,2	C,	--	4827369(+)	`CAGTGG/TTAATC`	2	--	ds500¹		2		WA	120
rs78647901^1,2	F,	--	4827397(+)	`TGAGGC/AGGAAG`	2	--	ds500¹		1		WA	118
rs114138879^1,2		--	4827492(+)	`TCAAGG/ATGGTG`	2	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for SEPT12 (4827670 - 4838522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SEPT12
3 CNVs: 5436 66925 72441
Human Gene Mutation Database (HGMD): SEPT12

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPT12

DNA2.0 Custom Variant and Variant Library Synthesis for SEPT12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEPT12 for disorders About MalaCards

SEPT12 for disorders About GeneDecksing

OMIM gene information: 611562 OMIM disorders: --

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10) [MIM:614822]. An infertility disorder

caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm

structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the

midpiece and the principal piece of the sperm tail

Export disorders for SEPT12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEPT12 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SEPT12)

Utopia: connect your pdf to the dynamic
world of online information

Expression profiling the human septin gene family. (PubMed id 15915442)^{1, 2, 3} Hall P.A....Russell S.E. (2005)
SEPT12 mutations cause male infertility with defective sperm annulus. (PubMed id 22275165)^{1, 2} Kuo Y.C.... Kuo P.L. (2012)
GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. (PubMed id 18443421)^{1, 2} Ding X.... Yu L. (2008)
SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. (PubMed id 18047794)^{1, 2} Ding X.... Yu L. (2007)
The septins. (PubMed id 14611653)^{1, 3} Kinoshita M. (2003)
Single nucleotide polymorphisms in the SEPTIN12 gene m ay be associated with azoospermia by meiotic arrest in Japanese men. (PubMed id 22116646)¹ Miyamoto T....Sengoku K. (2012)
SEPTIN12 genetic variants confer susceptibility to ter atozoospermia. (PubMed id 22479503)¹ Lin Y.H....Kuo P.L. (2012)
Single-nucleotide polymorphisms in the SEPTIN12 gene m ay be a genetic risk factor for Japanese patients with Sertoli cell-only syndrom e. (PubMed id 21636737)¹ Miyakawa H....Sengoku K. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
The expression level of septin12 is critical for spermiogenesis. (PubMed id 19359518)¹ Lin Y.H....Kuo P.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 124404	HGNC: 26348	AceView: FLJ25410	Ensembl:ENSG00000140623	euGenes: HUgn124404
ECgene: SEPT12	H-InvDB: SEPT12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEPT12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEPT12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEPT12 gene:
Search GeneIP for patents involving SEPT12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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