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SEPT12 Gene

protein-coding   GIFtS: 47
GCID: GC16M004829

Septin 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Septin 121 2
SPGF102 5
septin-122

External Ids:    HGNC: 263481   Entrez Gene: 1244042   Ensembl: ENSG000001406237   OMIM: 6115625   UniProtKB: Q8IYM13   

Export aliases for SEPT12 gene to outside databases

Previous GC identifer: GC16M004768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPT12 Gene:
This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases.
Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SEPT12 Gene:
SEPT12 (septin 12) is a protein-coding gene. Diseases associated with SEPT12 include spermatogenic failure 10, and spermatogenic failure. GO annotations related to this gene include phosphatidylinositol binding and protein homodimerization activity. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPT12 gene promoter:
         COUP-TF1   COUP   HNF-4alpha1   E47   PPAR-gamma1   COUP-TF   FOXO4   Hand1   PPAR-gamma2   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEPT12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPT12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SEPT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT12 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004829:  view genomic region     (about GC identifiers)

Start:
4,827,670 bp from pter      End:
4,838,522 bp from pter
Size:
10,853 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1 (See protein sequence)
Recommended Name: Septin-12  
Size: 358 amino acids; 40748 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By
similarity). Interacts with SEPT6 and SEPT11. Forms homodimers
Sequence caution: Sequence=AAH24017.1; Type=Erroneous initiation;
Secondary accessions: Q0P6B0 Q1PBH0 Q96LL0
Alternative splicing: 2 isoforms:  Q8IYM1-1   Q8IYM1-2   

Explore the universe of human proteins at neXtProt for SEPT12: NX_Q8IYM1

Explore proteomics data for SEPT12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEPT12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001147930.1  NP_653206.2  

    ENSEMBL proteins: 
     ENSP00000464775   ENSP00000379922   ENSP00000268231   ENSP00000467237   ENSP00000468601  
     ENSP00000467281  

    SEPT12 Human Recombinant Protein Products:

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    Novus Biologicals SEPT12 Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEPT: Septins

    3 InterPro protein domains:
     IPR016491 Septin
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8IYM1

    ProtoNet protein and cluster: Q8IYM1

    1 Blocks protein domain: IPB000038 Cell division/GTP binding protein

    UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1
    Similarity: Belongs to the septin family


    SEPT12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEP12_HUMAN, Q8IYM1
    Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI18047794
    GO:0005524ATP binding ----
    GO:0005525GTP binding ISS--
         
    SEPT12 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sept12):
     cellular  endocrine/exocrine gland  reproductive system 

    SEPT12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sept12tm1.1Plk for SEPT12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEPT12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEPT12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPT12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT12

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SEPT12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SEPT12:
    hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEPT12
    Predesigned siRNA for gene silencing in human, mouse, rat SEPT12

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEP12_HUMAN, Q8IYM1: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection,
    cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase,
    translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber ISS--
    GO:0005819spindle IDA18047794
    GO:0015630microtubule cytoskeleton IDA--
    GO:0016021integral component of membrane ----
    GO:0030496midbody IDA18047794

    SEPT12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPT12 About    
    See pathways by source

    SuperPathContained pathways About
    1Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SEPT12):
        Bacterial invasion of epithelial cells


    SEPT12 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEPT12
    Interactions:

        Search GeneGlobe Interaction Network for SEPT12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEPT12 (Q8IYM11, 3 ENSP000002682314) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT6Q141411, 3, ENSP000003415244EBI-2585067,EBI-745901 I2D: score=1 STRING: ENSP00000341524
    RALBP1ENSP000000193174STRING: ENSP00000019317
    SEPT1ENSP000003245114STRING: ENSP00000324511
    SEPT10ENSP000003808244STRING: ENSP00000380824
    SEPT11ENSP000002648934STRING: ENSP00000264893
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007059chromosome segregation ----
    GO:0051301cell division IEA--

    SEPT12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEPT12 (SEP12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEPT12 gene (2 alternative transcripts): 
    NM_001154458.2  NM_144605.4  

    Unigene Cluster for SEPT12:

    Septin 12
    Hs.126780  [show with all ESTs]
    Unigene Representative Sequence: EF620906
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588241 ENST00000396693(uc002cxq.3 uc002cxr.3 uc010bty.3)
    ENST00000268231 ENST00000587603 ENST00000590741 ENST00000591861 ENST00000590303
    ENST00000591624
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEPT12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SEPT12:
    hsa-miR-330-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEPT12
    Predesigned siRNA for gene silencing in human, mouse, rat SEPT12
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT12
    Primer
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    OriGene qPCR primer pairs and template standards for SEPT12
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEPT12
      QuantiTect SYBR Green Assays in human, mouse, rat SEPT12
      QuantiFast Probe-based Assays in human, mouse, rat SEPT12

    Additional mRNA sequence: 

    AK058139.1 AK098718.1 BC024017.1 BC035619.1 DQ456996.1 DQ517531.1 EF620906.1 

    3 DOTS entries:

    DT.95367332  DT.97807255  DT.120686226 

    Selected AceView cDNA sequences (see all 27):

    BI829633 AI393577 BC035619 AI554914 AA382830 NM_144605 AK058139 AK098718 
    BM564067 BP370735 BI830976 BI830266 BG719750 AI018797 AW137847 AA913452 
    BI520378 BI832349 BC024017 AI797580 AI890919 BF222811 AA448485 AI809012 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT12    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:              -           -                 -                       -                     
    SP2:              -           -                 -                                             
    SP3:              -           -                                                               
    SP4:                                            -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SEPT12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPT12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGATTCTGA
    SEPT12 Expression
    About this image


    SEPT12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Mature Sertoli Cells Seminiferous Tubules
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    SEPT12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPT12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126780

    UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SEPT12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEPT12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sept121 , 5 septin 121, 5 85.87(n)1
    88(a)1
      16 (2.49 cM)5
    710891  NM_027669.31  NP_081945.11 
     49868585 
    chicken
    (Gallus gallus)
    Aves SEPT121 septin 12 78.08(n)
    75.93(a)
      416408  XM_004945415.1  XP_004945472.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPT126
    septin 12
    65(a)
    1 ↔ 1
    GL343811.1(5474-55951)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057732.12   -- 76.05(n)    BC057732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sept121 septin 12 68.7(n)
    69.15(a)
      564600  XM_687930.4  XP_693022.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC36
    Component of the septin ring that is required for ...
    24(a)
    1 → many
    XII(762575-764137) YLR314C


    ENSEMBL Gene Tree for SEPT12 (if available)
    TreeFam Gene Tree for SEPT12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPT12 gene
    SEPT32  SEPT92  SEPT142  SEPT42  SEPT12  SEPT72  ENSG000002704662  SEPT62  
    SEPT112  SEPT22  SEPT102  SEPT82  SEPT52  
    14 SIMAP similar genes for SEPT12 using alignment to 6 protein entries:     SEP12_HUMAN (see all proteins):
    SEPT3    SEPT9    SEPT1    Nbla02942    SEPT7    SEPT2
    DKFZp686F17268    SEPT4    SEPT5    SEPT11    SEPT8    SEPT6
    SEPT14    SEPT10

    SEPT12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPT12 (see all 468)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996965261,2,,4
    Spermatogenic failure 10 (SPGF10)4 --4772442(+) GCAGCA/GTCTGG 4 T M mis10--------
    VAR_0680984
    Spermatogenic failure 10 (SPGF10)4--see VAR_0680982 D N mis40--------
    rs1906530061,2
    --4763620(+) AACCCA/GGGAGG 2 -- ds50010--------
    rs80544011,2
    C,F,A,H--4763638(+) tgtagT/Cgagcc 2 -- ds50018Minor allele frequency- C:0.33NA WA CSA 15
    rs1824672341,2
    C--4763658(+) CCATCA/GCACTC 2 -- ds50010--------
    rs1447451691,2
    --4763682(+) AAGAGC/TGAAAC 2 -- ds50010--------
    rs1467299551,2
    --4763716(+) ACAAAA/CAAAAA 2 -- ds50010--------
    rs1488456811,2
    C--4763717(+) CAAAAA/CAAAAA 2 -- ds50010--------
    rs1871078361,2
    --4763773(+) ACAAAA/CACATA 2 -- ds50010--------
    rs735132441,2
    C--4763796(+) CAGTGG/TTAATC 2 -- ds50012Minor allele frequency- T:0.02WA 120

    HapMap Linkage Disequilibrium report for SEPT12 (4827670 - 4838522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SEPT12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422516CNV Deletion17116639
    nsv905248CNV Loss21882294
    nsv905250CNV Loss21882294
    dgv2590n71CNV Loss21882294
    dgv2589n71CNV Loss21882294
    esv26756CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): SEPT12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPT12
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPT12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611562   
    OMIM disorders: 614822  
    UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1
  • Spermatogenic failure 10 (SPGF10) [MIM:614822]: An infertility disorder caused by spermatogenesis
    defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most
    prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal
    piece of the sperm tail. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for SEPT12:    
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    spermatogenic failure 10    spermatogenic failure    sertoli cell-only syndrome    male infertility
    azoospermia    infertility    multiple myeloma    myeloma


    SEPT12 for disorders           About GeneDecksing


    Export disorders for SEPT12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPT12 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SEPT12)
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    1. Expression profiling the human septin gene family. (PubMed id 15915442)1, 2, 3 Hall P.A.... Russell S.E.H. (J. Pathol. 2005)
    2. SEPT12 mutations cause male infertility with defective sperm annulus. (PubMed id 22275165)1, 2 Kuo Y.C.... Kuo P.L. (Hum. Mutat. 2012)
    3. GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. (PubMed id 18443421)1, 2 Ding X.... Yu L. (Mol. Cells 2008)
    4. SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. (PubMed id 18047794)1, 2 Ding X.... Yu L. (J. Biochem. Mol. Biol. 2007)
    5. The septins. (PubMed id 14611653)1, 3 Kinoshita M. (Genome Biol. 2003)
    6. Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men. (PubMed id 22116646)1 Miyamoto T....Sengoku K. (J. Assist. Reprod. Genet. 2012)
    7. SEPTIN12 genetic variants confer susceptibility to teratozoospermia. (PubMed id 22479503)1 Lin Y.H....Kuo P.L. (PLoS ONE 2012)
    8. Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome. (PubMed id 21636737)1 Miyakawa H....Sengoku K. (J. Androl. 2012)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. The expression level of septin12 is critical for spermiogenesis. (PubMed id 19359518)1 Lin Y.H....Kuo P.L. (Am. J. Pathol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124404 HGNC: 26348 AceView: FLJ25410 Ensembl:ENSG00000140623 euGenes: HUgn124404
    ECgene: SEPT12 Kegg: 124404 H-InvDB: SEPT12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPT12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPT12 gene:
    Search GeneIP for patents involving SEPT12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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