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SEPT12 Gene

protein-coding GIFtS: 47
GCID: GC16M004829

Septin 12

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Septin 12¹ ²
SPGF10² ⁵
septin-12²

External Ids:	HGNC: 26348¹	Entrez Gene: 124404²	Ensembl: ENSG00000140623⁷	OMIM: 611562⁵	UniProtKB: Q8IYM1³

Export aliases for SEPT12 gene to outside databases

Previous GC identifer: GC16M004768

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPT12 Gene:

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases.

Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SEPT12 Gene:

SEPT12 (septin 12) is a protein-coding gene. Diseases associated with SEPT12 include spermatogenic failure 10, and spermatogenic failure. GO annotations related to this gene include phosphatidylinositol binding and protein homodimerization activity. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NT_010393.17 NC_018927.2

Regulatory elements:

Regulatory transcription factor binding sites in the SEPT12 gene promoter:
COUP-TF1 COUP HNF-4alpha1 E47 PPAR-gamma1 COUP-TF FOXO4 Hand1 PPAR-gamma2 MRF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for SEPT12

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPT12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

SEPT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT12 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M004829: view genomic region (about GC identifiers)

Start:	4,827,670 bp from pter	End:	4,838,522 bp from pter
Size:	10,853 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1 (See protein sequence)

Recommended Name: Septin-12

Size: 358 amino acids; 40748 Da

Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with

cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By

similarity). Interacts with SEPT6 and SEPT11. Forms homodimers

Sequence caution: Sequence=AAH24017.1; Type=Erroneous initiation;

Secondary accessions: Q0P6B0 Q1PBH0 Q96LL0

Alternative splicing: 2 isoforms: Q8IYM1-1 Q8IYM1-2

Explore the universe of human proteins at neXtProt for SEPT12: NX_Q8IYM1

Explore proteomics data for SEPT12 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SEPT12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001147930.1 NP_653206.2

ENSEMBL proteins:

ENSP00000464775 ENSP00000379922 ENSP00000268231 ENSP00000467237 ENSP00000468601

ENSP00000467281

SEPT12 Human Recombinant Protein Products:

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SEPT12 Assay Products:

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	GenScript Custom Assay Services for SEPT12
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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SEPT: Septins

3 InterPro protein domains:

IPR016491 Septin

IPR000038 Cell_div_GTP-bd

IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry Q8IYM1

ProtoNet protein and cluster: Q8IYM1

1 Blocks protein domain: IPB000038 Cell division/GTP binding protein

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Similarity: Belongs to the septin family

SEPT12 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SEP12_HUMAN, Q8IYM1

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	IPI	18047794
GO:0005524	ATP binding	--	--
GO:0005525	GTP binding	ISS	--

SEPT12 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sept12):

cellular

endocrine/exocrine gland

reproductive system

SEPT12 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Sept12^tm1.1Plk for SEPT12

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEPT12

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT12

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		1 qRT-PCR Assays for microRNA that regulate SEPT12:
		hsa-miR-330-3p
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SEPT12
		Predesigned siRNA for gene silencing in human, mouse, rat SEPT12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEPT12

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SEP12_HUMAN, Q8IYM1: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection,

cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase,

translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
cytosol	3
nucleus	2
extracellular	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): Selected cellular component terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	ISS	--
GO:0005819	spindle	IDA	18047794
GO:0015630	microtubule cytoskeleton	IDA	--
GO:0016021	integral component of membrane	--	--
GO:0030496	midbody	IDA	18047794

SEPT12 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SEPT12 About

See pathways by source

SuperPath

Contained pathways About

Bacterial invasion of epithelial cells

Bacterial invasion of epithelial cells

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for SEPT12):

Bacterial invasion of epithelial cells

SEPT12 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SEPT12
Interactions:

Search GeneGlobe Interaction Network for SEPT12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SEPT12 (Q8IYM1^{1, 3} ENSP00000268231⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT6	Q14141¹^,³, ENSP00000341524⁴	EBI-2585067,EBI-745901 I2D: score=1 STRING: ENSP00000341524
RALBP1	ENSP00000019317⁴	STRING: ENSP00000019317
SEPT1	ENSP00000324511⁴	STRING: ENSP00000324511
SEPT10	ENSP00000380824⁴	STRING: ENSP00000380824
SEPT11	ENSP00000264893⁴	STRING: ENSP00000264893

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0007059	chromosome segregation	--	--
GO:0051301	cell division	IEA	--

SEPT12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SEPT12 (SEP12)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SEPT12 gene (2 alternative transcripts):

NM_001154458.2 NM_144605.4

Unigene Cluster for SEPT12:

Septin 12

Hs.126780 [show with all ESTs]

Unigene Representative Sequence: EF620906

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588241 ENST00000396693(uc002cxq.3 uc002cxr.3 uc010bty.3)

ENST00000268231 ENST00000587603 ENST00000590741 ENST00000591861 ENST00000590303

ENST00000591624

miRNA Products:		Block miRNA regulation of human, mouse, rat SEPT12 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate SEPT12:
		hsa-miR-330-3p
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Primer Products:		OriGene qPCR primer pairs and template standards for SEPT12 OriGene qSTAR qPCR primer pairs in human, mouse for SEPT12
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SEPT12
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		QuantiFast Probe-based Assays in human, mouse, rat SEPT12

Additional mRNA sequence:

AK058139.1 AK098718.1 BC024017.1 BC035619.1 DQ456996.1 DQ517531.1 EF620906.1

3 DOTS entries:

DT.95367332 DT.97807255 DT.120686226

Selected AceView cDNA sequences (see all 27):

BI829633 AI393577 BC035619 AI554914 AA382830 NM_144605 AK058139 AK098718

BM564067 BP370735 BI830976 BI830266 BG719750 AI018797 AW137847 AA913452

BI520378 BI832349 BC024017 AI797580 AI890919 BF222811 AA448485 AI809012

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT12 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12
SP1:					-				-						-								-
SP2:					-				-						-
SP3:					-				-
SP4:															-
SP5:

ECgene alternative splicing isoforms for SEPT12

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SEPT12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACGATTCTGA

About this image

SEPT12 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Testis (Reproductive System)
Mature Sertoli Cells Seminiferous Tubules

Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

SEPT12 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SEPT12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.126780

UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Tissue specificity: Widely expressed

Custom PCR Arrays for SEPT12

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SEPT12 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sept12^{1 , 5}	septin 12^{1, 5}	85.87(n)¹ 88(a)¹		16 (2.49 cM)⁵ 71089¹ NM_027669.3¹ NP_081945.1¹ 4986858⁵
chicken (Gallus gallus)	Aves	SEPT12¹	septin 12	78.08(n) 75.93(a)		416408 XM_004945415.1 XP_004945472.1
lizard (Anolis carolinensis)	Reptilia	SEPT12⁶	septin 12	65(a)	1 ↔ 1	GL343811.1(5474-55951)
African clawed frog (Xenopus laevis)	Amphibia	BC057732.1²	--	76.05(n)		BC057732.1
zebrafish (Danio rerio)	Actinopterygii	sept12¹	septin 12	68.7(n) 69.15(a)		564600 XM_687930.4 XP_693022.3
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC3⁶	Component of the septin ring that is required for ...	24(a)	1 → many	XII(762575-764137) YLR314C

ENSEMBL Gene Tree for SEPT12 (if available)
TreeFam Gene Tree for SEPT12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SEPT12 gene

SEPT3² SEPT9² SEPT14² SEPT4² SEPT1² SEPT7² ENSG00000270466² SEPT6²

SEPT11² SEPT2² SEPT10² SEPT8² SEPT5²

14 SIMAP similar genes for SEPT12 using alignment to 6 protein entries: SEP12_HUMAN (see all proteins):

SEPT3 SEPT9 SEPT1 Nbla02942 SEPT7 SEPT2

DKFZp686F17268 SEPT4 SEPT5 SEPT11 SEPT8 SEPT6

SEPT14 SEPT10

SEPT12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199696526^1,2,,4		Spermatogenic failure 10 (SPGF10)⁴ --	4772442(+)	`GCAGCA/GTCTGG`	4	T M	mis¹		0	--	--	--	--
VAR_068098⁴		Spermatogenic failure 10 (SPGF10)⁴	--	see VAR_068098	2	D N	mis⁴		0	--	--	--	--
rs190653006^1,2		--	4763620(+)	`AACCCA/GGGAGG`	2	--	ds500¹		0	--	--	--	--
rs8054401^1,2	C,F,A,H	--	4763638(+)	`tgtagT/Cgagcc`	2	--	ds500¹		8		NA WA CSA	15
rs182467234^1,2	C	--	4763658(+)	`CCATCA/GCACTC`	2	--	ds500¹		0	--	--	--	--
rs144745169^1,2		--	4763682(+)	`AAGAGC/TGAAAC`	2	--	ds500¹		0	--	--	--	--
rs146729955^1,2		--	4763716(+)	`ACAAAA/CAAAAA`	2	--	ds500¹		0	--	--	--	--
rs148845681^1,2	C	--	4763717(+)	`CAAAAA/CAAAAA`	2	--	ds500¹		0	--	--	--	--
rs187107836^1,2		--	4763773(+)	`ACAAAA/CACATA`	2	--	ds500¹		0	--	--	--	--
rs73513244^1,2	C	--	4763796(+)	`CAGTGG/TTAATC`	2	--	ds500¹		2		WA	120

HapMap Linkage Disequilibrium report for SEPT12 (4827670 - 4838522 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for SEPT12: About this table

Variant ID	Type	Subtype	PubMed ID
esv2422516	CNV	Deletion	17116639
nsv905248	CNV	Loss	21882294
nsv905250	CNV	Loss	21882294
dgv2590n71	CNV	Loss	21882294
dgv2589n71	CNV	Loss	21882294
esv26756	CNV	Gain+Loss	19812545

Human Gene Mutation Database (HGMD): SEPT12

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SEPT12

DNA2.0 Custom Variant and Variant Library Synthesis for SEPT12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611562
OMIM disorders: 614822
UniProtKB/Swiss-Prot: SEP12_HUMAN, Q8IYM1

Spermatogenic failure 10 (SPGF10) [MIM:614822]: An infertility disorder caused by spermatogenesis

defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most

prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal

piece of the sperm tail. Note=The disease is caused by mutations affecting the gene represented in this entry

8 diseases for SEPT12:
About MalaCards

spermatogenic failure 10 spermatogenic failure sertoli cell-only syndrome male infertility

azoospermia infertility multiple myeloma myeloma

SEPT12 for disorders About GeneDecksing

Export disorders for SEPT12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEPT12 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with SEPT12)

Utopia: connect your pdf to the dynamic
world of online information

Expression profiling the human septin gene family. (PubMed id 15915442)^{1, 2, 3} Hall P.A.... Russell S.E.H. (J. Pathol. 2005)
SEPT12 mutations cause male infertility with defective sperm annulus. (PubMed id 22275165)^{1, 2} Kuo Y.C.... Kuo P.L. (Hum. Mutat. 2012)
GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. (PubMed id 18443421)^{1, 2} Ding X.... Yu L. (Mol. Cells 2008)
SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. (PubMed id 18047794)^{1, 2} Ding X.... Yu L. (J. Biochem. Mol. Biol. 2007)
The septins. (PubMed id 14611653)^{1, 3} Kinoshita M. (Genome Biol. 2003)
Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men. (PubMed id 22116646)¹ Miyamoto T....Sengoku K. (J. Assist. Reprod. Genet. 2012)
SEPTIN12 genetic variants confer susceptibility to teratozoospermia. (PubMed id 22479503)¹ Lin Y.H....Kuo P.L. (PLoS ONE 2012)
Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome. (PubMed id 21636737)¹ Miyakawa H....Sengoku K. (J. Androl. 2012)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
The expression level of septin12 is critical for spermiogenesis. (PubMed id 19359518)¹ Lin Y.H....Kuo P.L. (Am. J. Pathol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 124404	HGNC: 26348	AceView: FLJ25410	Ensembl:ENSG00000140623	euGenes: HUgn124404
ECgene: SEPT12	Kegg: 124404	H-InvDB: SEPT12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEPT12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEPT12 gene
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Patent Information for SEPT12 gene:
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