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SEPT11 Gene

protein-coding   GIFtS: 53
GCID: GC04P077870

Septin 11

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Septin 111 2
septin-112

External Ids:    HGNC: 255891   Entrez Gene: 557522   Ensembl: ENSG000001387587   OMIM: 6128875   UniProtKB: Q9NVA23   

Export aliases for SEPT11 gene to outside databases

Previous GC identifers: GC04P078330 GC04P078229 GC04P078089 GC04P073622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPT11 Gene:
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a
variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 (PubMed
15196925); Nagata et al., 2004 (PubMed 15485874)).(supplied by OMIM, Jul 2009)

GeneCards Summary for SEPT11 Gene:
SEPT11 (septin 11) is a protein-coding gene. Diseases associated with SEPT11 include chronic neutrophilic leukemia, and hereditary neuralgic amyotrophy. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEP11_HUMAN, Q9NVA2
Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the
cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic
connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry
process, but restricts its efficacy

Gene Wiki entry for SEPT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPT11 gene promoter:
         SREBP-1c   MyoD   AP-4   SREBP-1b   POU2F1   SREBP-1a   HNF-1   POU2F1a   Chx10   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEPT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SEPT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P077870:  view genomic region     (about GC identifiers)

Start:
77,870,856 bp from pter      End:
77,961,537 bp from pter
Size:
90,682 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEP11_HUMAN, Q9NVA2 (See protein sequence)
Recommended Name: Septin-11  
Size: 429 amino acids; 49398 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation.
Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers
Sequence caution: Sequence=BAB55250.1; Type=Erroneous initiation; Sequence=CAB53741.2; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: B7Z7Z6 E9KL32 Q4W5G1 Q7L4N1 Q96SP1 Q9UFY9
Alternative splicing: 2 isoforms:  Q9NVA2-1   Q9NVA2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEPT11: NX_Q9NVA2

Explore proteomics data for SEPT11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175, Lys326
  • Modification sites at PhosphoSitePlus

  • See SEPT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060713.1  
    ENSEMBL proteins: 
     ENSP00000264893   ENSP00000426344   ENSP00000420839   ENSP00000424925   ENSP00000422896  
     ENSP00000425262   ENSP00000422047   ENSP00000423103   ENSP00000424122   ENSP00000443701  

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    SEPT11 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEPT: Septins

    3 InterPro protein domains:
     IPR016491 Septin
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NVA2

    ProtoNet protein and cluster: Q9NVA2

    1 Blocks protein domain: IPB000038 Cell division/GTP binding protein

    UniProtKB/Swiss-Prot: SEP11_HUMAN, Q9NVA2
    Similarity: Belongs to the septin family


    SEPT11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEP11_HUMAN, Q9NVA2
    Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the
    cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic
    connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry
    process, but restricts its efficacy

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15485874
    GO:0005525GTP binding IEA--
         
    SEPT11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEPT11
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    miRTarBase miRNAs that target SEPT11:
    hsa-mir-186-5p (MIRT021162), hsa-mir-155-5p (MIRT020977), hsa-mir-222-3p (MIRT046824), hsa-mir-17-5p (MIRT050926), hsa-mir-101-3p (MIRT027350)

    Block miRNA regulation of human, mouse, rat SEPT11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPT11 (see all 93):
    hsa-miR-3678-3p hsa-miR-3938 hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-1304
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEP11_HUMAN, Q9NVA2: Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell
    projection, axon (By similarity). Note=Partly colocalizes with stress fibers and microtubules. During bacterial
    infection, displays a collar shape structure next to actin at the pole of invading bacteria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA15485874
    GO:0005737cytoplasm ----
    GO:0030054cell junction IEA--
    GO:0030424axon IEA--
    GO:0031105septin complex IEA--

    SEPT11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPT11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SEPT11):
        Bacterial invasion of epithelial cells


    SEPT11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEPT11
    Interactions:

        Search GeneGlobe Interaction Network for SEPT11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEPT11 (Q9NVA21, 3 ENSP000002648934) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT5Q997191, 3, ENSP000003913114EBI-957999,EBI-373345 I2D: score=2 STRING: ENSP00000391311
    SEPT7Q161813, ENSP000003819924I2D: score=3 STRING: ENSP00000381992
    SEPT9Q9UHD83, ENSP000003912494I2D: score=2 STRING: ENSP00000391249
    SEPT2Q150193, ENSP000003531574I2D: score=1 STRING: ENSP00000353157
    SEPT1Q8WYJ63, ENSP000003245114I2D: score=1 STRING: ENSP00000324511
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0051291protein heterooligomerization IDA15485874
    GO:0051301cell division IEA--

    SEPT11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEPT11 (SEP11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEPT11 gene: 
    NM_018243.2  

    Unigene Cluster for SEPT11:

    Septin 11
    Hs.128199  [show with all ESTs]
    Unigene Representative Sequence: CR627457
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264893(uc003hkj.3 uc011cca.2) ENST00000502584 ENST00000510641(uc010ijh.1)
    ENST00000505788 ENST00000512575 ENST00000510515 ENST00000504637 ENST00000512778
    ENST00000512333 ENST00000504460 ENST00000506047(uc003hkk.1) ENST00000506731
    ENST00000502401 ENST00000513373 ENST00000513697 ENST00000515671 ENST00000541121

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat SEPT11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPT11 (see all 93):
    hsa-miR-3678-3p hsa-miR-3938 hsa-miR-300 hsa-miR-15a hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-1304
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SEPT11
      QuantiFast Probe-based Assays in human, mouse, rat SEPT11

    Additional mRNA sequence: 

    AK001711.1 AK027279.1 AK027633.1 AK094473.1 AK124592.1 AK302700.1 AL110300.1 BC008083.2 
    BC063615.1 BC064934.1 BX648411.1 CR627457.1 GU727629.1 

    Selected DOTS entries (see all 35):

    DT.100885359  DT.102839659  DT.214465  DT.218079  DT.121254547  DT.75100653  DT.91772453  DT.121254690 
    DT.100885349  DT.121254674  DT.100885366  DT.100044828  DT.91765025  DT.121254618  DT.409874  DT.40110509 
    DT.453243  DT.91772457  DT.92027843  DT.95251735  DT.100725134  DT.100885346  DT.121254587  DT.121254597 

    Selected AceView cDNA sequences (see all 473):

    BE294838 BU070312 BC063615 AI160354 W81208 BX509536 BP375224 CR625731 
    F03182 CA414463 BE501876 AI167167 AA150683 AI949540 AK124592 AW300644 
    AA743540 AK027633 N59663 AI742961 BM754365 CA419142 BQ017993 AI393461 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEPT11 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                      -     -                 -                                               -                           
    SP2:                    -     -     -     -     -                 -                                               -                           
    SP3:                                                              -                                                                           
    SP4:                    -     -     -     -     -                 -                                                                           
    SP5:                                            -                 -                                                                           


    ECgene alternative splicing isoforms for SEPT11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPT11 expression in normal human tissues (normalized intensities)      SEPT11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEPT11 Expression
    About this image


    SEPT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Adipose (Muscoskeletal System)
     
     Gall Bladder (Hepatobiliary System)
    SEPT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPT11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128199

    UniProtKB/Swiss-Prot: SEP11_HUMAN, Q9NVA2
    Tissue specificity: Widely expressed, except in leukocytes

        Custom PCR Arrays for SEPT11
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SEPT11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sept111 , 5 septin 111, 5 88.97(n)1
    99.53(a)1
      5 (47.29 cM)5
    523981  NM_001009818.11  NP_001009818.11 
     930934575 
    chicken
    (Gallus gallus)
    Aves SEPT111 septin 11 83.61(n)
    97.44(a)
      422635  XM_004941161.1  XP_004941218.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPT116
    septin 11
    97(a)
    1 ↔ 1
    5(146258438-146379320)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253422 Xenopus laevis transcribed sequence with moderate similarity more 80.1(n)    BU916194.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sept8b1 septin 8b 72.53(n)
    78.39(a)
      571702  NM_001083566.1  NP_001077035.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sep51 Septin 5 62.97(n)
    69.53(a)
      43990  NM_143704.2  NP_651961.1 


    ENSEMBL Gene Tree for SEPT11 (if available)
    TreeFam Gene Tree for SEPT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPT11 gene
    SEPT32  SEPT92  SEPT142  SEPT42  SEPT12  SEPT122  SEPT72  ENSG000002704662  
    SEPT62  SEPT22  SEPT102  SEPT82  SEPT52  
    17 SIMAP similar genes for SEPT11 using alignment to 8 protein entries:     SEP11_HUMAN (see all proteins):
    SEPT6    SEPT10    SEPT8    DKFZp547B243    DKFZp564M1416    SEPT14
    SEPT9    MAFK    SEPT2    SEPT3    SEPT7    DKFZp686F17268
    Nbla02942    SEPT1    SEPT12    SEPT5    SEPT4

    SEPT11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPT11 (see all 1612)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839313781,2
    --77869056(+) TTTTTA/TAGAGC 1 -- us2k10--------
    rs1479379981,2
    --77869103(+) AGGTGC/TTGGGA 1 -- us2k10--------
    rs1886027481,2
    --77869454(+) CGCCCA/GGGGAC 1 -- us2k10--------
    rs3727222051,2
    C--77869455(+) GCCCGA/GGGACG 1 -- us2k10--------
    rs38067271,2
    C--77869532(+) GGACAG/AGGAGA 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1918701671,2
    --77869545(+) CAAGGC/TCCCAG 1 -- us2k10--------
    rs1179840901,2
    F--77869630(+) TTCAGG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs752729311,2
    F--77869872(+) GACACG/CCAGTA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs726651101,2
    C,F--77870028(+) GTCGCC/GGGGTC 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs1157921181,2
    F--77870078(+) TGTGGC/TTGCTC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for SEPT11 (77870856 - 77961537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEPT11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829973CNV Loss17160897
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPT11
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPT11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612887    OMIM disorders: --

    UniProtKB/Swiss-Prot: SEP11_HUMAN, Q9NVA2
  • Note=A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia.
    Translocation t(4;11)(q21;q23) with KMT2A/MLL1

  • 14 diseases for SEPT11:    About MalaCards
    chronic neutrophilic leukemia    hereditary neuralgic amyotrophy    epididymitis    choroiditis
    cystic fibrosis    retinitis    hepatocellular carcinoma    obesity
    endotheliitis    leukemia    multiple myeloma    myeloma
    malaria    neuronitis


    SEPT11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEPT11
    Human Genome Epidemiology (HuGE) Navigator: SEPT11 (1 document)

    Export disorders for SEPT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPT11 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SEPT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). (PubMed id 14999297)1, 2, 3 Kojima K.... Fujita S. (Leukemia 2004)
    2. Septin 11 restricts InlB-mediated invasion by Listeria. (PubMed id 19234302)1, 2, 9 Mostowy S.... Cossart P. (J. Biol. Chem. 2009)
    3. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. (PubMed id 17546647)1, 2 Sudo K.... Nagata K. (Hum. Mutat. 2007)
    6. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. (PubMed id 15485874)1, 2 Nagata K.... Inagaki M. (J. Biol. Chem. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Biochemical and cell biological characterization of a mammalian septin, Sept11. (PubMed id 15196925)1, 2 Hanai N.... Inagaki M. (FEBS Lett. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Analysis of mammalian septin expression in human malignant brain tumors. (PubMed id 15140406)1, 3 Kim D.S....Rutka J.T. (Neoplasia 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55752 HGNC: 25589 AceView: SEPT11 Ensembl:ENSG00000138758 euGenes: HUgn55752
    ECgene: SEPT11 Kegg: 55752 H-InvDB: SEPT11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPT11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPT11 gene:
    Search GeneIP for patents involving SEPT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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