Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEPT11 Gene

Aliases for SEPT11 Gene

  • Septin 11 2 3 5
  • Septin-11 3

External Ids for SEPT11 Gene

Previous GeneCards Identifiers for SEPT11 Gene

  • GC04P078330
  • GC04P078229
  • GC04P078089
  • GC04P077870
  • GC04P073622

Summaries for SEPT11 Gene

Entrez Gene Summary for SEPT11 Gene

  • SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]

GeneCards Summary for SEPT11 Gene

SEPT11 (Septin 11) is a Protein Coding gene. Diseases associated with SEPT11 include Chronic Neutrophilic Leukemia. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT11 Gene

  • Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Gene Wiki entry for SEPT11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT11 Gene

Genomics for SEPT11 Gene

Regulatory Elements for SEPT11 Gene

Enhancers for SEPT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G077005 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.9 +59.3 59269 6.3 ELF3 HNRNPUL1 PKNOX1 FOXA2 INSM2 FEZF1 ZNF366 GATA2 ZSCAN5C FOS SEPT11 SOWAHB CCNG2 CCNI PIR49374 LOC105377291
GH04G076981 1.5 Ensembl ENCODE dbSUPER 19.5 +39.2 39212 15.3 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A TCF12 GATA2 CBX5 FOS SEPT11 SOWAHB PIR49374 LOC105377291
GH04G077020 1.3 Ensembl ENCODE dbSUPER 11.5 +72.5 72493 4.2 FOXA2 NFIB ARID4B RAD21 RARA YY1 CEBPB PPARG NR2F2 CEBPA SEPT11 FAM47E LOC105377291 PIR49374
GH04G077092 1.4 FANTOM5 Ensembl ENCODE 10.4 +143.7 143659 2.2 FOXA2 ATF1 GATA4 ELK1 FOS CREM ZNF263 CEBPB PPARG ATF4 CCNG2 SEPT11 SOWAHB RPL7P17 GC04M077080
GH04G077014 0.7 ENCODE dbSUPER 18.8 +65.9 65850 1.7 MAFK ATF2 NFE2L2 SEPT11 PIR49374 LOC105377291
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEPT11 on UCSC Golden Path with GeneCards custom track

Promoters for SEPT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169562 497 3601 HDGF HNRNPUL1 PKNOX1 CREB3L1 AGO1 SIN3A ARID4B DMAP1 ZNF2 YY1

Genomic Location for SEPT11 Gene

Chromosome:
4
Start:
76,949,703 bp from pter
End:
77,040,384 bp from pter
Size:
90,682 bases
Orientation:
Plus strand

Genomic View for SEPT11 Gene

Genes around SEPT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT11 Gene

Proteins for SEPT11 Gene

  • Protein details for SEPT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVA2-SEP11_HUMAN
    Recommended name:
    Septin-11
    Protein Accession:
    Q9NVA2
    Secondary Accessions:
    • B7Z7Z6
    • E9KL32
    • Q4W5G1
    • Q7L4N1
    • Q96SP1
    • Q9UFY9

    Protein attributes for SEPT11 Gene

    Size:
    429 amino acids
    Molecular mass:
    49398 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers.
    SequenceCaution:
    • Sequence=BAB55250.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB53741.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SEPT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT11 Gene

Post-translational modifications for SEPT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEPT11 Gene

Domains & Families for SEPT11 Gene

Gene Families for SEPT11 Gene

Protein Domains for SEPT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVA2

UniProtKB/Swiss-Prot:

SEP11_HUMAN :
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT11: view

No data available for Suggested Antigen Peptide Sequences for SEPT11 Gene

Function for SEPT11 Gene

Molecular function for SEPT11 Gene

UniProtKB/Swiss-Prot Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Gene Ontology (GO) - Molecular Function for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15485874
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SEPT11: view

Phenotypes for SEPT11 Gene

genes like me logo Genes that share phenotypes with SEPT11: view

Animal Model Products

miRNA for SEPT11 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEPT11 Gene

Localization for SEPT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT11 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEPT11 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 15485874
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with SEPT11: view

Pathways & Interactions for SEPT11 Gene

genes like me logo Genes that share pathways with SEPT11: view

Pathways by source for SEPT11 Gene

1 KEGG pathway for SEPT11 Gene

Gene Ontology (GO) - Biological Process for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051291 protein heterooligomerization IDA 15485874
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SEPT11: view

No data available for SIGNOR curated interactions for SEPT11 Gene

Transcripts for SEPT11 Gene

Unigene Clusters for SEPT11 Gene

Septin 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1: - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for SEPT11 Gene

GeneLoc Exon Structure for
SEPT11
ECgene alternative splicing isoforms for
SEPT11

Expression for SEPT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEPT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEPT11 Gene

This gene is overexpressed in Bone marrow stromal cell (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEPT11 Gene



Protein tissue co-expression partners for SEPT11 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for SEPT11 Gene:

Hs.128199

mRNA Expression by UniProt/SwissProt for SEPT11 Gene:

Q9NVA2-SEP11_HUMAN
Tissue specificity: Widely expressed, except in leukocytes.

Evidence on tissue expression from TISSUES for SEPT11 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Skin(4.4)
  • Intestine(4.3)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with SEPT11: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEPT11 Gene

Orthologs for SEPT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPT11 34 35
  • 99.92 (n)
oppossum
(Monodelphis domestica)
Mammalia SEPT11 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT11 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPT11 34 35
  • 93.73 (n)
cow
(Bos Taurus)
Mammalia SEPT11 34 35
  • 92.08 (n)
rat
(Rattus norvegicus)
Mammalia Sept11 34
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Sept11 34 16 35
  • 88.97 (n)
chicken
(Gallus gallus)
Aves SEPT11 34 35
  • 83.61 (n)
lizard
(Anolis carolinensis)
Reptilia SEPT11 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sept11 34
  • 80.57 (n)
Str.15839 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25342 34
zebrafish
(Danio rerio)
Actinopterygii sept8b 34
  • 72.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sep5 34
  • 62.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 72 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5368 34
Species where no ortholog for SEPT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT11 Gene

ENSEMBL:
Gene Tree for SEPT11 (if available)
TreeFam:
Gene Tree for SEPT11 (if available)

Paralogs for SEPT11 Gene

Paralogs for SEPT11 Gene

genes like me logo Genes that share paralogs with SEPT11: view

Variants for SEPT11 Gene

Sequence variations from dbSNP and Humsavar for SEPT11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000003782 -- 76,998,343(+) CATCT(C/T)TCTGT intron-variant, nc-transcript-variant
rs10000055 -- 76,961,307(+) GCGAG(G/T)ATAAA intron-variant
rs10000606 -- 77,040,224(+) TACCA(A/G)GACCC intron-variant, downstream-variant-500B
rs1000068660 -- 77,030,311(+) TTCAG(C/T)ATCCC intron-variant
rs1000179874 -- 76,957,568(+) ATCCT(C/G)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT11 Gene

Variant ID Type Subtype PubMed ID
esv3451658 CNV insertion 20981092
nsv7363 OTHER inversion 18451855
nsv829973 CNV loss 17160897

Variation tolerance for SEPT11 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEPT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT11 Gene

Disorders for SEPT11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEPT11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic neutrophilic leukemia
  • cnl
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SEP11_HUMAN
  • Note=A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.

Relevant External Links for SEPT11

Genetic Association Database (GAD)
SEPT11
Human Genome Epidemiology (HuGE) Navigator
SEPT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEPT11
genes like me logo Genes that share disorders with SEPT11: view

No data available for Genatlas for SEPT11 Gene

Publications for SEPT11 Gene

  1. Septin 11 restricts InlB-mediated invasion by Listeria. (PMID: 19234302) Mostowy S. … Cossart P. (J. Biol. Chem. 2009) 3 4 22 64
  2. FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). (PMID: 14999297) Kojima K. … Fujita S. (Leukemia 2004) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 64
  5. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. (PMID: 20419844) Huang G.L. … Wang H.Y. (World J. Gastroenterol. 2010) 3 22 64

Products for SEPT11 Gene

Sources for SEPT11 Gene

Content
Loading form....