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Aliases for SEPT11 Gene

Aliases for SEPT11 Gene

  • Septin 11 2 3
  • Septin-11 3

External Ids for SEPT11 Gene

Previous GeneCards Identifiers for SEPT11 Gene

  • GC04P078330
  • GC04P078229
  • GC04P078089
  • GC04P077870
  • GC04P073622

Summaries for SEPT11 Gene

Entrez Gene Summary for SEPT11 Gene

  • SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]

GeneCards Summary for SEPT11 Gene

SEPT11 (Septin 11) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT11 Gene

  • Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Gene Wiki entry for SEPT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT11 Gene

Genomics for SEPT11 Gene

Regulatory Elements for SEPT11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEPT11 Gene

Start:
76,949,703 bp from pter
End:
77,040,384 bp from pter
Size:
90,682 bases
Orientation:
Plus strand

Genomic View for SEPT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT11 Gene

Proteins for SEPT11 Gene

  • Protein details for SEPT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVA2-SEP11_HUMAN
    Recommended name:
    Septin-11
    Protein Accession:
    Q9NVA2
    Secondary Accessions:
    • B7Z7Z6
    • E9KL32
    • Q4W5G1
    • Q7L4N1
    • Q96SP1
    • Q9UFY9

    Protein attributes for SEPT11 Gene

    Size:
    429 amino acids
    Molecular mass:
    49398 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers.
    SequenceCaution:
    • Sequence=BAB55250.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB53741.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SEPT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT11 Gene

Proteomics data for SEPT11 Gene at MOPED

Post-translational modifications for SEPT11 Gene

  • Ubiquitination at Lys175 and Lys326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEPT11 Gene

Domains for SEPT11 Gene

Gene Families for SEPT11 Gene

HGNC:

Protein Domains for SEPT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVA2

UniProtKB/Swiss-Prot:

SEP11_HUMAN :
  • Q9NVA2
Domain:
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT11: view

No data available for Suggested Antigen Peptide Sequences for SEPT11 Gene

Function for SEPT11 Gene

Molecular function for SEPT11 Gene

UniProtKB/Swiss-Prot Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Gene Ontology (GO) - Molecular Function for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15485874
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SEPT11: view

Animal Model Products

CRISPR Products

miRNA for SEPT11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPT11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEPT11 Gene

Localization for SEPT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT11 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPT11 Gene COMPARTMENTS Subcellular localization image for SEPT11 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 15485874
GO:0005737 cytoplasm IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
GO:0031105 septin complex --
genes like me logo Genes that share ontologies with SEPT11: view

Pathways for SEPT11 Gene

genes like me logo Genes that share pathways with SEPT11: view

Pathways by source for SEPT11 Gene

1 KEGG pathway for SEPT11 Gene

Gene Ontology (GO) - Biological Process for SEPT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051291 protein heterooligomerization IDA 15485874
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SEPT11: view

Transcripts for SEPT11 Gene

Unigene Clusters for SEPT11 Gene

Septin 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPT11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEPT11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1: - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for SEPT11 Gene

GeneLoc Exon Structure for
SEPT11
ECgene alternative splicing isoforms for
SEPT11

Expression for SEPT11 Gene

mRNA expression in normal human tissues for SEPT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT11 Gene

SOURCE GeneReport for Unigene cluster for SEPT11 Gene Hs.128199

mRNA Expression by UniProt/SwissProt for SEPT11 Gene

Q9NVA2-SEP11_HUMAN
Tissue specificity: Widely expressed, except in leukocytes.
genes like me logo Genes that share expressions with SEPT11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SEPT11 Gene

Orthologs for SEPT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPT11 35
  • 99.92 (n)
  • 100 (a)
SEPT11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEPT11 35
  • 92.08 (n)
  • 100 (a)
SEPT11 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPT11 35
  • 93.73 (n)
  • 100 (a)
SEPT11 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sept11 35
  • 88.97 (n)
  • 99.53 (a)
Sept11 16
Sept11 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPT11 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT11 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sept11 35
  • 89.72 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves SEPT11 35
  • 83.61 (n)
  • 97.44 (a)
SEPT11 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPT11 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25342 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sept11 35
  • 80.57 (n)
  • 93.24 (a)
Str.15839 35
zebrafish
(Danio rerio)
Actinopterygii sept8b 35
  • 72.53 (n)
  • 78.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sep5 35
  • 62.97 (n)
  • 69.53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5368 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
Species with no ortholog for SEPT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT11 Gene

ENSEMBL:
Gene Tree for SEPT11 (if available)
TreeFam:
Gene Tree for SEPT11 (if available)

Paralogs for SEPT11 Gene

Paralogs for SEPT11 Gene

genes like me logo Genes that share paralogs with SEPT11: view

Variants for SEPT11 Gene

Sequence variations from dbSNP and Humsavar for SEPT11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10391 -- 77,039,917(-) GAATA(A/C)CCAAT downstream-variant-500B, utr-variant-3-prime
rs734655 -- 76,984,986(+) TGGGT(C/T)GTGCC intron-variant
rs872563 -- 76,993,657(+) CCATC(A/T)CATAC intron-variant
rs872564 -- 76,993,903(+) TTCTC(A/G)TGTTT intron-variant, upstream-variant-2KB
rs873090 -- 76,949,863(-) GCTTT(A/C)CGCCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SEPT11 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv829973 CNV Loss 17160897

Relevant External Links for SEPT11 Gene

HapMap Linkage Disequilibrium report
SEPT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT11 Gene

Disorders for SEPT11 Gene

UniProtKB/Swiss-Prot

SEP11_HUMAN
  • Note=A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.

Relevant External Links for SEPT11

Genetic Association Database (GAD)
SEPT11
Human Genome Epidemiology (HuGE) Navigator
SEPT11
genes like me logo Genes that share disorders with SEPT11: view

Publications for SEPT11 Gene

  1. Septin 11 restricts InlB-mediated invasion by Listeria. (PMID: 19234302) Mostowy S. … Cossart P. (J. Biol. Chem. 2009) 3 4 23
  2. FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23). (PMID: 14999297) Kojima K. … Fujita S. (Leukemia 2004) 2 3 4
  3. Analysis of mammalian septin expression in human malignant brain tumors. (PMID: 15140406) Kim D.S. … Rutka J.T. (Neoplasia 2004) 2 3
  4. Biochemical and cell biological characterization of a mammalian septin, Sept11. (PMID: 15196925) Hanai N. … Inagaki M. (FEBS Lett. 2004) 3 4
  5. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. (PMID: 15485874) Nagata K. … Inagaki M. (J. Biol. Chem. 2004) 3 4

Products for SEPT11 Gene

Sources for SEPT11 Gene

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