Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEPT10 Gene

protein-coding GIFtS: 47
GCID: GC02M110300

septin 10

Search for SEPT10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Septin 10¹ ²
FLJ11619¹
Septin-10¹

External Ids:	HGNC: 14349¹	Entrez Gene: 151011²	Ensembl: ENSG00000186522⁷	OMIM: 611737⁵	UniProtKB: Q9P0V9³

Export aliases for SEPT10 gene to outside databases

Previous GC identifers: GC02M109850 GC02M109912 GC02M109657 GC02M103756

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT10:

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes

to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on

chromosome 8. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9

Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEPT10 gene promoter:
LHX3b/Lhx3b Lmo2 MyoD IRF-1 Nkx2-5 C/EBPalpha IRF-7A LHX3a/Lhx3a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SEPT10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13

SEPT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M110300: view genomic region (about GC identifiers)

Start:	110,300,376 bp from pter	End:	110,371,783 bp from pter
Size:	71,408 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9 (See protein sequence)

Recommended Name: Septin-10

Size: 454 amino acids; 52593 Da

Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with

cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By

similarity)

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein, detected in

the nucleus (PubMed:12711328)

Sequence caution: Sequence=AAF67469.1; Type=Frameshift; Positions=444;

Secondary accessions: B3KRQ9 Q86VP5 Q9HAH6

Alternative splicing: 3 isoforms: Q9P0V9-1 Q9P0V9-2 Q9P0V9-3 (Ref.2 (AAH50345) sequence differs from that shown due to a frameshift in position 503)

Explore the universe of human proteins at neXtProt for SEPT10: NX_Q9P0V9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P0V9

SEPT10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_653311.1 NP_848699.1

ENSEMBL proteins:

ENSP00000349116 ENSP00000380824 ENSP00000380826 ENSP00000407790 ENSP00000396728

ENSP00000446331 ENSP00000399270 ENSP00000445707 ENSP00000416597 ENSP00000441218

ENSP00000396051 ENSP00000408392 ENSP00000334234 ENSP00000439364

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SEPT10 OriGene Protein Over-expression Lysate: SEPT10 OriGene Custom Protein Services for SEPT10
	GenScript Custom Purified and Recombinant Proteins Services for SEPT10
	Novus Biologicals SEPT10 Protein Novus Biologicals SEPT10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031105	septin complex	IEA	--

SEPT10 for ontologies About GeneDecksing

SEPT10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SEPT10
	GenScript Custom Superior Antibodies Services for SEPT10
	Novus Biologicals SEPT10 Antibodies
	Search for Antibodies for SEPT10 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for SEPT10

Assay Products for SEPT10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEPT10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEPT10 for domains About GeneDecksing

2 InterPro domains/families:

IPR000038 Cell_div_GTP-bd

IPR016491 Septin

Graphical View of Domain Structure for InterPro Entry Q9P0V9

ProtoNet protein and cluster: Q9P0V9

1 Blocks protein family: IPB000038 Cell division/GTP binding protein

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9

Similarity: Belongs to the septin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9

Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)

miRNA Products:		miRTarBase miRNAs that target SEPT10: hsa-mir-192 (MIRT004860)

		OriGene 3'-UTR Clone (see all 2): SEPT10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT10
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT10 (see all 28):
		hsa-miR-3910 hsa-miR-875-3p hsa-miR-4328 hsa-miR-4251 hsa-miR-1297 hsa-miR-223 hsa-miR-374c hsa-miR-124

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT10 OriGene shRNA RFP: SEPT10 OriGene siRNA: SEPT10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEPT10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for SEPT10
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEPT10
		Search LifeMap BioReagents cell lines for SEPT10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005525	GTP binding	IEA	--

SEPT10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SEPT10:

Decreased cilium length after

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEPT10

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/18 Interacting proteins for SEPT10 (Q9P0V9^{2, 3} ENSP00000380824⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT2	Q15019³, ENSP00000353157⁴	I2D: score=5 STRING: ENSP00000353157
SEPT7	Q16181³, ENSP00000381992⁴	I2D: score=2 STRING: ENSP00000381992
SEPT4	O43236³	I2D: score=1
SYVN1	Q86TM6³	I2D: score=1
ZBTB16	Q05516³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0051301	cell division	IEA	--

SEPT10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEPT10

1 HMDB Compound for SEPT10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about SEPT10 / SEP10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEPT10 gene (2 alternative transcripts):

NM_144710.3 NM_178584.2

Unigene Cluster for SEPT10:

Septin 10

Hs.469615 [show with all ESTs]

Unigene Representative Sequence: AB208875

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356688(uc002tev.1 uc010ywu.1 uc002tey.3) ENST00000397712(uc010fjo.3 uc002tew.3 uc002tex.3 uc010ywv.2)

ENST00000397714 ENST00000437928 ENST00000415095 ENST00000468616 ENST00000483047(uc002tez.1)

ENST00000486678 ENST00000425498 ENST00000493445 ENST00000423520 ENST00000461295

ENST00000411469 ENST00000442746 ENST00000334001 ENST00000545389

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEPT10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT10
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT10 (see all 28):
		hsa-miR-3910 hsa-miR-875-3p hsa-miR-4328 hsa-miR-4251 hsa-miR-1297 hsa-miR-223 hsa-miR-374c hsa-miR-124

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT10 OriGene shRNA RFP: SEPT10 OriGene siRNA: SEPT10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for SEPT10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEPT10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10

Additional cDNA sequence:

AB208875.1 AF146760.1 AF316880.1 AK021681.1 AK022682.1 AK092033.1 AK125706.1 AK292038.1

AK294427.1 AK295560.1 AL049934.1 AL353938.1 BC020502.1 BC050345.1 NR_047585.1

11 DOTS entries:

DT.80100472 DT.92030851 DT.95108491 DT.92458088 DT.99981848 DT.100737584 DT.121002173 DT.92458093

DT.121473586 DT.92458073 DT.121002171

24/220 AceView cDNA sequences (see all 220):

BM474486 AW074503 BE889899 BQ574423 BF437363 AW514882 BX494629 AV651619

AI928261 AF316880 AW452298 CD679502 BQ440879 BM467784 BI757810 AA514883

BM463739 AI342192 BM474125 AF146760 BM452966 BQ894369 AW472997 AA778483

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT10 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b
SP1:							-
SP2:
SP3:											-		-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for SEPT10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEPT10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGTATCAC

About this image
See SEPT10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEPT10

SOURCE GeneReport for Unigene cluster: Hs.469615

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9

Tissue specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and

lung, as well as various tumor cell lines

SABiosciences Custom PCR Arrays for SEPT10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEPT10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEPT10 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEPT10¹	septin 10	75.51(n) 74.88(a)		418732 XM_416931.3 XP_416931.2
lizard (Anolis carolinensis)	Reptilia	SEPT10⁶	--	74(a)	1 → many	3(106900653-106922075)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7604²	Xenopus laevis transcribed sequence with moderate similarity more	77.03(n)		CA985775.1
zebrafish (Danio rerio)	Actinopterygii	sept10¹	septin 10	72.33(n) 79.67(a)		550129 NM_001017557.1 NP_001017557.1
fruit fly (Drosophila melanogaster)	Insecta	Sep2⁶ Sep5⁶	Sep5	67(a) 60(a)	many ↔ many many ↔ many	3R(16411851-16414085) 2R(3847638-3849427)
worm (Caenorhabditis elegans)	Secernentea	unc-61⁶ unc-59⁶	UNCoordinated family member (unc-59)	35(a) 26(a)	1 ↔ many possible ortholog	V(14731080-14734222) I(13629214-13633485)

ENSEMBL Gene Tree for SEPT10 (if available)
TreeFam Gene Tree for SEPT10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEPT10 gene

SEPT3² SEPT9² SEPT14² SEPT4² SEPT1² SEPT7² SEPT12² SEPT6²

SEPT7L² SEPT11² SEPT2² SEPT8² SEPT5²

18/19 SIMAP similar genes for SEPT10 using alignment to 13 protein entries: SEP10_HUMAN (see all proteins) (see all similar genes):

DKFZp564M1416 DKFZp547B243 SEPT11 SEPT6 SEPT8 SEPT14

MAFK SEPT9 SEPT7L SEPT3 SEPT2 SEPT7

SEPT5 DKFZp686F17268 Nbla02942 SEPT4 SEPT1 SEPT12

SEPT10 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SEPT10
PGOHUM00000249350

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146065671^1,2		--	110299881(+)	`CATTGC/TGGCTG`	3	--	ds500¹		0	--	--	--	--
rs112480971^1,2	C,	--	110299898(+)	`GAGTGG/AGGCTT`	3	--	ds500¹		1		NA	2
rs61354480^1,2	C,	--	110299902(+)	`GAGGCT/CTTCTC`	3	--	ds500¹		4		WA NA EA	360
rs114342997^1,2	F,	--	110299914(+)	`CAGCAG/ATCATC`	3	--	ds500¹		1		WA	118
rs112093750^1,2	C,	--	110299925(+)	`AGCAGT/GACAAA`	3	--	ds500¹		2		CSA WA	120
rs193118669^1,2		--	110299935(+)	`AACGAC/TCGCCC`	3	--	ds500¹		0	--	--	--	--
rs184766367^1,2		--	110299979(+)	`ATTACA/GTTCTT`	3	--	ds500¹		0	--	--	--	--
rs79198034^1,2	C,F,	--	110300018(+)	`CCATTC/ACAACA`	3	--	ds500¹		1		EA	120
rs189101921^1,2		--	110300120(+)	`ACTCCC/TGCAGT`	3	--	ds500¹		0	--	--	--	--
rs181441002^1,2		--	110300173(+)	`AGTACC/TGTGAT`	3	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEPT10 (110300376 - 110371783 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEPT10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPT10

DNA2.0 Custom Variant and Variant Library Synthesis for SEPT10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEPT10 for disorders About MalaCards

SEPT10 for disorders About GeneDecksing

OMIM gene information: 611737 OMIM disorders: --

Export disorders for SEPT10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEPT10 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SEPT10)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. (PubMed id 12711328)^{1, 2, 3, 9} Sui L.... Cao X. (2003)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. (PubMed id 17657217)^{1, 9} Benedetti D....Gattei V. (2008)
Identification of a novel role of Septin 10 in paclita xel-resistance in cancers through a functional genomics screen. (PubMed id 22320903)¹ Xu M....Kuroda M. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 151011	HGNC: 14349	AceView: SEPT10	Ensembl:ENSG00000186522	euGenes: HUgn151011
ECgene: SEPT10	H-InvDB: SEPT10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEPT10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEPT10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SEPT10 gene:
Search GeneIP for patents involving SEPT10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SEPT10
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPT10		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEPT10
	OriGene Protein Over-expression Lysate for SEPT10		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SEPT10		OriGene 3'-UTR Clone for SEPT10
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPT10
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SEPT10		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SEPT10		OriGene Custom Protein Services for SEPT10
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEPT10
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEPT10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10

	GenScript Custom Purified and Recombinant Proteins Services for SEPT10		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SEPT10
	GenScript Custom Assay Services for SEPT10		GenScript Custom Superior Antibodies Services for SEPT10
	GenScript Custom overexpressing Cell Line Services for SEPT10		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SEPT10 promoter
	Search Chromatin IP Primers for SEPT10
	RT² qPCR Primer Assay in human, mouse, rat SEPT10
	Search GNC Networks for SEPT10
	SABiosciences Custom PCR Arrays for SEPT10

Search Tocris compounds for SEPT10

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SEPT10 antibodies
	SEPT10 proteins
	SEPT10 lysates

	Search for Antibodies for SEPT10 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SEPT10
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for SEPT10

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SEPT10
	Browse SwitchGear Promoter luciferase reporter plasmids for SEPT10

Search ThermoFisher Antibodies for SEPT10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SEPT10 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SEPT10 Gene

septin 10

Aliases
for SEPT10 gene

Summaries
for SEPT10 gene

Genomic Views
for SEPT10 gene

Proteins
for SEPT10 gene

Protein Domains /
Families
for SEPT10 gene

Function
for SEPT10 gene

Pathways & Interactions
for SEPT10 gene

Drugs & Compounds
for SEPT10 gene

Transcripts
for SEPT10 gene

Expression
for SEPT10 gene

Orthologs
for SEPT10 gene

Paralogs
for SEPT10 gene

Genomic Variants
for SEPT10 gene

Disorders / Diseases
for SEPT10 gene

Publications
for SEPT10 gene

External Searches for SEPT10 gene

Genome Databases showing SEPT10 gene

Other Databases showing SEPT10 gene

Specialized Databases showing SEPT10 gene

Intellectual Property
for SEPT10 gene

Products
for SEPT10 gene

View Random Gene

Advanced Search

Export list of displayed genes

SEPT10 Gene

septin 10

Aliasesfor SEPT10 gene

Summariesfor SEPT10 gene

Genomic Viewsfor SEPT10 gene

Proteinsfor SEPT10 gene

Protein Domains /Familiesfor SEPT10 gene

Functionfor SEPT10 gene

Pathways & Interactionsfor SEPT10 gene

Drugs & Compoundsfor SEPT10 gene

Transcriptsfor SEPT10 gene

Expression for SEPT10 gene

Orthologsfor SEPT10 gene

Paralogsfor SEPT10 gene

Genomic Variantsfor SEPT10 gene

Disorders / Diseasesfor SEPT10 gene

Publicationsfor SEPT10 gene

External Searches for SEPT10 gene

Genome Databases showing SEPT10 gene

Other Databases showing SEPT10 gene

Specialized Databases showing SEPT10 gene

Intellectual Propertyfor SEPT10 gene

Productsfor SEPT10 gene

View Random Gene

Aliases
for SEPT10 gene

Summaries
for SEPT10 gene

Genomic Views
for SEPT10 gene

Proteins
for SEPT10 gene

Protein Domains /
Families
for SEPT10 gene

Function
for SEPT10 gene

Pathways & Interactions
for SEPT10 gene

Drugs & Compounds
for SEPT10 gene

Transcripts
for SEPT10 gene

Expression
for SEPT10 gene

Orthologs
for SEPT10 gene

Paralogs
for SEPT10 gene

Genomic Variants
for SEPT10 gene

Disorders / Diseases
for SEPT10 gene

Publications
for SEPT10 gene

Intellectual Property
for SEPT10 gene

Products
for SEPT10 gene