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Aliases for SEPT10 Gene

Aliases for SEPT10 Gene

  • Septin 10 2 3
  • Sept1-Like 2
  • Septin-10 3

External Ids for SEPT10 Gene

Previous GeneCards Identifiers for SEPT10 Gene

  • GC02M109850
  • GC02M109912
  • GC02M109657
  • GC02M110300
  • GC02M103756

Summaries for SEPT10 Gene

Entrez Gene Summary for SEPT10 Gene

  • This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for SEPT10 Gene

SEPT10 (Septin 10) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT10 Gene

  • Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT10 Gene

Genomics for SEPT10 Gene

Regulatory Elements for SEPT10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEPT10 Gene

Start:
109,542,797 bp from pter
End:
109,614,206 bp from pter
Size:
71,410 bases
Orientation:
Minus strand

Genomic View for SEPT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT10 Gene

Proteins for SEPT10 Gene

  • Protein details for SEPT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0V9-SEP10_HUMAN
    Recommended name:
    Septin-10
    Protein Accession:
    Q9P0V9
    Secondary Accessions:
    • B3KRQ9
    • Q86VP5
    • Q9HAH6

    Protein attributes for SEPT10 Gene

    Size:
    454 amino acids
    Molecular mass:
    52593 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
    SequenceCaution:
    • Sequence=AAF67469.1; Type=Frameshift; Positions=444; Evidence={ECO:0000305};

    Alternative splice isoforms for SEPT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT10 Gene

Proteomics data for SEPT10 Gene at MOPED

Post-translational modifications for SEPT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEPT10 Gene

Domains for SEPT10 Gene

Gene Families for SEPT10 Gene

HGNC:

Protein Domains for SEPT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0V9

UniProtKB/Swiss-Prot:

SEP10_HUMAN :
  • Q9P0V9
Domain:
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT10: view

No data available for Suggested Antigen Peptide Sequences for SEPT10 Gene

Function for SEPT10 Gene

Molecular function for SEPT10 Gene

UniProtKB/Swiss-Prot Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

Gene Ontology (GO) - Molecular Function for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SEPT10: view

Phenotypes for SEPT10 Gene

GenomeRNAi human phenotypes for SEPT10:
genes like me logo Genes that share phenotypes with SEPT10: view

miRNA for SEPT10 Gene

miRTarBase miRNAs that target SEPT10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEPT10 Gene

Localization for SEPT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT10 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Using a GFP-fusion protein, detected in the nucleus. {ECO:0000269 PubMed:12711328}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPT10 Gene COMPARTMENTS Subcellular localization image for SEPT10 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0031105 septin complex --
genes like me logo Genes that share ontologies with SEPT10: view

Pathways for SEPT10 Gene

SuperPathways for SEPT10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SEPT10: view

No data available for Pathways by source for SEPT10 Gene

Compounds for SEPT10 Gene

(1) HMDB Compounds for SEPT10 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SEPT10: view

Transcripts for SEPT10 Gene

Unigene Clusters for SEPT10 Gene

Septin 10:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPT10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6: - - - - - - - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - - - - - -
SP11: - -
SP12: - - - - - - - - -
SP13:

Relevant External Links for SEPT10 Gene

GeneLoc Exon Structure for
SEPT10
ECgene alternative splicing isoforms for
SEPT10

Expression for SEPT10 Gene

mRNA expression in normal human tissues for SEPT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT10 Gene

SOURCE GeneReport for Unigene cluster for SEPT10 Gene Hs.469615

mRNA Expression by UniProt/SwissProt for SEPT10 Gene

Q9P0V9-SEP10_HUMAN
Tissue specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines.
genes like me logo Genes that share expressions with SEPT10: view

Expression partners for SEPT10 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SEPT10 Gene

Orthologs for SEPT10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPT10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEPT10 35
  • 88.42 (n)
  • 89.16 (a)
SEPT10 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEPT10 35
  • 91.34 (n)
  • 92.71 (a)
SEPT10 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sept10 35
  • 85.81 (n)
  • 85.89 (a)
Sept10 16
Sept10 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEPT10 35
  • 99.93 (n)
  • 99.78 (a)
rat
(Rattus norvegicus)
Mammalia Sept10 35
  • 86.78 (n)
  • 86.7 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT10 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPT10 35
  • 75.13 (n)
  • 75.13 (a)
SEPT10 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPT10 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sept10 35
  • 71.44 (n)
  • 73.38 (a)
Str.6034 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7604 35
zebrafish
(Danio rerio)
Actinopterygii sept10 35
  • 72.33 (n)
  • 79.67 (a)
sept10 36
  • 77 (a)
OneToMany
sept10 36
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToMany
Species with no ortholog for SEPT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT10 Gene

ENSEMBL:
Gene Tree for SEPT10 (if available)
TreeFam:
Gene Tree for SEPT10 (if available)

Paralogs for SEPT10 Gene

Paralogs for SEPT10 Gene

Pseudogenes.org Pseudogenes for SEPT10 Gene

genes like me logo Genes that share paralogs with SEPT10: view

Variants for SEPT10 Gene

Sequence variations from dbSNP and Humsavar for SEPT10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs717188 -- 109,571,024(-) GCAAG(A/G)GACAA intron-variant
rs717189 -- 109,571,282(-) AGTCC(A/G)TTCTC intron-variant
rs747445 -- 109,595,096(+) TGGCC(A/G)GGGTG intron-variant
rs753492 -- 109,591,085(+) gtaca(C/T)TATAT intron-variant
rs767628 -- 109,562,498(-) ATCTG(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT10 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv2874 CNV Loss 18451855
nsv510884 CNV Complex 20534489
nsv829617 CNV Gain 20364138
esv2657195 CNV Deletion 23128226

Relevant External Links for SEPT10 Gene

HapMap Linkage Disequilibrium report
SEPT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT10 Gene

Disorders for SEPT10 Gene

Relevant External Links for SEPT10

Genetic Association Database (GAD)
SEPT10

No disorders were found for SEPT10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SEPT10 Gene

Publications for SEPT10 Gene

  1. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. (PMID: 12711328) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. (PMID: 17657217) Benedetti D. … Gattei V. (Leukemia 2008) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SEPT10 Gene

Sources for SEPT10 Gene

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