Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPT10 Gene

protein-coding   GIFtS: 52
GCID: GC02M110300

Septin 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Septin 101 2
sept1-like1
septin-102

External Ids:    HGNC: 143491   Entrez Gene: 1510112   Ensembl: ENSG000001865227   OMIM: 6117375   UniProtKB: Q9P0V93   

Export aliases for SEPT10 gene to outside databases

Previous GC identifers: GC02M109850 GC02M109912 GC02M109657 GC02M103756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT10 Gene:
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein
localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene
is located on chromosome 8. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Apr 2012)

GeneCards Summary for SEPT10 Gene: 
SEPT10 (septin 10) is a protein-coding gene. Diseases associated with SEPT10 include b-cell chronic lymphocytic leukemia, and chronic lymphocytic leukemia. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT3.

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9
Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPT10 gene promoter:
         LHX3b/Lhx3b   Lmo2   MyoD   IRF-1   Nkx2-5   C/EBPalpha   IRF-7A   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SEPT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

SEPT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M110300:  view genomic region     (about GC identifiers)

Start:
110,300,376 bp from pter      End:
110,371,783 bp from pter
Size:
71,408 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9 (See protein sequence)
Recommended Name: Septin-10  
Size: 454 amino acids; 52593 Da
Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with
cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By
similarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein,
detected in the nucleus (PubMed:12711328)
Sequence caution: Sequence=AAF67469.1; Type=Frameshift; Positions=444;
Secondary accessions: B3KRQ9 Q86VP5 Q9HAH6
Alternative splicing: 3 isoforms:  Q9P0V9-1   Q9P0V9-2   Q9P0V9-3   (Ref.2 (AAH50345) sequence differs from that shown due to a frameshift in position 503)

Explore the universe of human proteins at neXtProt for SEPT10: NX_Q9P0V9

Explore proteomics data for SEPT10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P0V9

  • SEPT10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEPT10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_653311.1  NP_848699.1  

    ENSEMBL proteins: 
     ENSP00000349116   ENSP00000380824   ENSP00000380826   ENSP00000407790   ENSP00000396728  
     ENSP00000446331   ENSP00000399270   ENSP00000445707   ENSP00000416597   ENSP00000441218  
     ENSP00000396051   ENSP00000408392   ENSP00000334234   ENSP00000439364  

    Human Recombinant Protein Products for SEPT10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEPT10
    OriGene Protein Over-expression Lysate for SEPT10
    OriGene MassSpec for SEPT10 
    OriGene Custom Protein Services for SEPT10
    GenScript Custom Purified and Recombinant Proteins Services for SEPT10
    Novus Biologicals SEPT10 Protein
    Novus Biologicals SEPT10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031105septin complex IEA--

    SEPT10 for ontologies           About GeneDecksing



    SEPT10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEPT10
    GenScript Custom Superior Antibodies Services for SEPT10
    Novus Biologicals SEPT10 Antibodies
    Abcam antibodies for SEPT10
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SEPT10
    LSBio Antibodies in human, mouse, rat for SEPT10 

    Assay Products for SEPT10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEPT10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEPT10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SEPT: Septins

    3 InterPro protein domains:
     IPR000038 Cell_div_GTP-bd
     IPR027417 P-loop_NTPase
     IPR016491 Septin

    Graphical View of Domain Structure for InterPro Entry Q9P0V9

    ProtoNet protein and cluster: Q9P0V9

    1 Blocks protein domain: IPB000038 Cell division/GTP binding protein

    UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9
    Similarity: Belongs to the septin family


    SEPT10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEP10_HUMAN, Q9P0V9
    Function: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    SEPT10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEPT10:
     Decreased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPT10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPT10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPT10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPT10 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEPT10:
    hsa-mir-192 (MIRT004860)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT10
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT10 (see all 28):
    hsa-miR-3910 hsa-miR-875-3p hsa-miR-4328 hsa-miR-4251 hsa-miR-1297 hsa-miR-223 hsa-miR-374c hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPT10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEPT10
    Sirion Biotech Customized adenovirus for overexpression of SEPT10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SEPT10 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SEPT10
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10
    Sirion Biotech Customized lentivirus for stable overexpression of SEPT10 
                         Customized lentivirus expression plasmids for stable overexpression of SEPT10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEPT10
    Search LifeMap BioReagents cell lines for SEPT10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for SEPT10 (Q9P0V92, 3 ENSP000003808244) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEPT2Q150193, ENSP000003531574I2D: score=5 STRING: ENSP00000353157
    SEPT7Q161813, ENSP000003819924I2D: score=2 STRING: ENSP00000381992
    SEPT4O432363I2D: score=1 
    SYVN1Q86TM63I2D: score=1 
    ZBTB16Q055163I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0051301cell division IEA--

    SEPT10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEPT10 (SEP10)

    1 HMDB Compound for SEPT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about SEPT10 / SEP10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEPT10 gene (2 alternative transcripts): 
    NM_144710.3  NM_178584.2  

    Unigene Cluster for SEPT10:

    Septin 10
    Hs.469615  [show with all ESTs]
    Unigene Representative Sequence: AB208875
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356688(uc002tev.1 uc010ywu.1 uc002tey.3) ENST00000397712(uc010fjo.3 uc002tew.3 uc002tex.3 uc010ywv.2)
    ENST00000397714 ENST00000437928 ENST00000415095 ENST00000468616 ENST00000483047(uc002tez.1)
    ENST00000486678 ENST00000425498 ENST00000493445 ENST00000423520 ENST00000461295
    ENST00000411469 ENST00000442746 ENST00000334001 ENST00000545389
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPT10
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPT10 (see all 28):
    hsa-miR-3910 hsa-miR-875-3p hsa-miR-4328 hsa-miR-4251 hsa-miR-1297 hsa-miR-223 hsa-miR-374c hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPT10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10
    Clone
    Products:
         
    OriGene clones in human, mouse for SEPT10 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SEPT10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10
    Sirion Biotech Customized lentivirus for stable overexpression of SEPT10 
                         Customized lentivirus expression plasmids for stable overexpression of SEPT10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEPT10
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10

    Additional mRNA sequence: 

    AB208875.1 AF146760.1 AF316880.1 AK021681.1 AK022682.1 AK092033.1 AK125706.1 AK292038.1 
    AK294427.1 AK295560.1 AL049934.1 AL353938.1 BC020502.1 BC050345.1 NR_047585.1 

    11 DOTS entries:

    DT.80100472  DT.92030851  DT.95108491  DT.92458088  DT.99981848  DT.100737584  DT.121002171  DT.121002173 
    DT.92458093  DT.121473586  DT.92458073 

    24/220 AceView cDNA sequences (see all 220):

    AF316880 NM_178584 AK022682 BQ441873 BM474486 BE221709 BE018393 AW472997 
    AV652151 BP365982 AA778483 AI248569 AI928261 BQ004232 BI757810 BM467784 
    BM452966 AK092033 CB045753 CD679502 AI342192 NM_144710 BM988805 AI735104 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT10 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
    SP1:                    -                                                                                                                           
    SP2:                                                                                                                                                
    SP3:                                -     -     -     -     -                                                                                       
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for SEPT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPT10 expression in normal human tissues (normalized intensities)      SEPT10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGTATCAC
    SEPT10 Expression
    About this image


    SEPT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See SEPT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPT10

    SOURCE GeneReport for Unigene cluster: Hs.469615

    UniProtKB/Swiss-Prot: SEP10_HUMAN, Q9P0V9
    Tissue specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver
    and lung, as well as various tumor cell lines

        SABiosciences Custom PCR Arrays for SEPT10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEPT10
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPT10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPT10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEPT10 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sept101 , 5 septin 101, 5 85.81(n)1
    85.89(a)1
      10 (29.48 cM)5
    1030801  NM_001024910.31  NP_001020081.21 
     591641135 
    chicken
    (Gallus gallus)
    Aves SEPT101 septin 10 75.51(n)
    74.88(a)
      418732  XM_416931.3  XP_416931.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    72(a)
    1 → many
    3(106895687-106922147)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76042 Xenopus laevis transcribed sequence with moderate similarity more 77.03(n)    CA985775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sept101 septin 10 72.33(n)
    79.67(a)
      550129  NM_001017557.1  NP_001017557.1 


    ENSEMBL Gene Tree for SEPT10 (if available)
    TreeFam Gene Tree for SEPT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEPT10 gene
    SEPT32  SEPT92  SEPT142  SEPT42  SEPT12  SEPT122  SEPT72  ENSG000002704662  
    SEPT62  SEPT112  SEPT22  SEPT82  SEPT52  
    18 SIMAP similar genes for SEPT10 using alignment to 13 protein entries:     SEP10_HUMAN (see all proteins):
    DKFZp564M1416    DKFZp547B243    SEPT11    SEPT6    SEPT8    SEPT14
    MAFK    SEPT9    SEPT3    SEPT7    SEPT2    SEPT5
    DKFZp686F17268    Nbla02942    SEPT4    SEPT1    SEPT12    DKFZp586I031

    SEPT10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEPT10
    PGOHUM00000249350


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1359 SNPs in SEPT10 are shown (see all 1359)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558803281,2
    C--103795681(+) CACAC-/AC/AC 
    ACACACAC
    TCACT
    3 -- int11NA 2
    rs1460656711,2
    --110299881(+) CATTGC/TGGCTG 3 -- ds50010--------
    rs1124809711,2
    C,F--110299898(+) GAGTGG/AGGCTT 3 -- ds50011Minor allele frequency- A:0.50NA 2
    rs613544801,2
    C--110299902(+) GAGGCT/CTTCTC 3 -- ds50014Minor allele frequency- C:0.11WA NA EA 360
    rs1143429971,2
    F--110299914(+) CAGCAG/ATCATC 3 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1120937501,2
    C--110299925(+) AGCAGT/GACAAA 3 -- ds50012Minor allele frequency- G:0.05CSA WA 120
    rs1931186691,2
    C--110299935(+) AACGAC/TCGCCC 3 -- ds50010--------
    rs1847663671,2
    --110299979(+) ATTACA/GTTCTT 3 -- ds50010--------
    rs791980341,2
    C,F--110300018(+) CCATTC/ACAACA 3 -- ds50011Minor allele frequency- A:0.12EA 120
    rs1891019211,2
    --110300120(+) ACTCCC/TGCAGT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for SEPT10 (110300376 - 110371783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SEPT10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657195CNV Deletion23128226
    nsv2874CNV Loss18451855
    nsv874777CNV Gain21882294
    nsv829617CNV Gain20364138
    nsv510884CNV Complex20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPT10
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611737    OMIM disorders: --

    3 diseases for SEPT10:    About MalaCards
    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    leukemia


    SEPT10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEPT10

    Export disorders for SEPT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPT10 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SEPT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. (PubMed id 12711328)1, 2, 3, 9 Sui L.... Cao X. (2003)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. (PubMed id 17657217)1, 9 Benedetti D....Gattei V. (2008)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Identification of a novel role of Septin 10 in paclita xel-resistance in cancers through a functional genomics screen. (PubMed id 22320903)1 Xu M....Kuroda M. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151011 HGNC: 14349 AceView: SEPT10 Ensembl:ENSG00000186522 euGenes: HUgn151011
    ECgene: SEPT10 H-InvDB: SEPT10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEPT10 gene:
    Search GeneIP for patents involving SEPT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEPT10  
     OriGene qPCR primer pairs and template standards for SEPT10   OriGene Protein Over-expression Lysate for SEPT10  
     OriGene MassSpec something-or-other for SEPT10   OriGene clones in human, mouse for SEPT10  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEPT10   OriGene Purified Protein for SEPT10  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEPT10   OriGene Custom Protein Services for SEPT10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEPT10
     QIAGEN SeqTarget long-range PCR primers for resequencing SEPT10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPT10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPT10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPT10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPT10
     GenScript Custom Purified and Recombinant Proteins Services for SEPT10 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SEPT10
     GenScript Custom Assay Services for SEPT10 GenScript Custom Superior Antibodies Services for SEPT10
     GenScript Custom overexpressing Cell Line Services for SEPT10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SEPT10 promoter
     Search Chromatin IP Primers for SEPT10
     RT2 qPCR Primer Assay in human, mouse, rat SEPT10
     Search GNC Networks for SEPT10
     SABiosciences Custom PCR Arrays for SEPT10
     Search Tocris compounds for SEPT10 (SEP10)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEPT10 antibodies
     SEPT10 proteins
     SEPT10 lysates
     Antibodies for SEPT10
     See all of Abcam's Antibodies, Kits and Proteins for SEPT10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SEPT10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPT10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SEPT10
     Browse SwitchGear Promoter luciferase reporter plasmids for SEPT10
     ThermoFisher Antibodies for SEPT10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPT10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPT10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPT10
    Customized:
     lentivirus for stable overexpression of SEPT10
     lentivirus expression plasmids for stable overexpression of SEPT10
     adenovirus for overexpression of SEPT10
     LSBio Antibodies in human, mouse, rat for SEPT10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEPT10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4