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Aliases for SEPT10 Gene

Aliases for SEPT10 Gene

  • Septin 10 2 3 5
  • Sept1-Like 2

External Ids for SEPT10 Gene

Previous GeneCards Identifiers for SEPT10 Gene

  • GC02M109850
  • GC02M109912
  • GC02M109657
  • GC02M110300
  • GC02M103756

Summaries for SEPT10 Gene

Entrez Gene Summary for SEPT10 Gene

  • This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for SEPT10 Gene

SEPT10 (Septin 10) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT6.

UniProtKB/Swiss-Prot for SEPT10 Gene

  • Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT10 Gene

Genomics for SEPT10 Gene

Regulatory Elements for SEPT10 Gene

Enhancers for SEPT10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEPT10 on UCSC Golden Path with GeneCards custom track

Promoters for SEPT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEPT10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEPT10 Gene

109,542,797 bp from pter
109,614,206 bp from pter
71,410 bases
Minus strand

Genomic View for SEPT10 Gene

Genes around SEPT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT10 Gene

Proteins for SEPT10 Gene

  • Protein details for SEPT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KRQ9
    • Q86VP5
    • Q9HAH6

    Protein attributes for SEPT10 Gene

    454 amino acids
    Molecular mass:
    52593 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
    • Sequence=AAF67469.1; Type=Frameshift; Positions=444; Evidence={ECO:0000305};

    Alternative splice isoforms for SEPT10 Gene


neXtProt entry for SEPT10 Gene

Proteomics data for SEPT10 Gene at MOPED

Post-translational modifications for SEPT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SEPT10 Gene

Domains & Families for SEPT10 Gene

Gene Families for SEPT10 Gene

Protein Domains for SEPT10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT10: view

No data available for Suggested Antigen Peptide Sequences for SEPT10 Gene

Function for SEPT10 Gene

Molecular function for SEPT10 Gene

UniProtKB/Swiss-Prot Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

Gene Ontology (GO) - Molecular Function for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEPT10: view

Phenotypes for SEPT10 Gene

genes like me logo Genes that share phenotypes with SEPT10: view

Animal Models for SEPT10 Gene

MGI Knock Outs for SEPT10:

miRNA for SEPT10 Gene

miRTarBase miRNAs that target SEPT10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEPT10 Gene

Localization for SEPT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT10 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Using a GFP-fusion protein, detected in the nucleus. {ECO:0000269 PubMed:12711328}.

Subcellular locations from

Jensen Localization Image for SEPT10 Gene COMPARTMENTS Subcellular localization image for SEPT10 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SEPT10 Gene

Pathways & Interactions for SEPT10 Gene

SuperPathways for SEPT10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEPT10 Gene


No data available for Pathways by source and SIGNOR curated interactions for SEPT10 Gene

Drugs & Compounds for SEPT10 Gene

(1) Drugs for SEPT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SEPT10: view

Transcripts for SEPT10 Gene

Unigene Clusters for SEPT10 Gene

Septin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: -
SP3: - - - - -
SP6: - - - - - - - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - - - - - -
SP11: - -
SP12: - - - - - - - - -

Relevant External Links for SEPT10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEPT10 Gene

mRNA expression in normal human tissues for SEPT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEPT10 Gene

SOURCE GeneReport for Unigene cluster for SEPT10 Gene Hs.469615

mRNA Expression by UniProt/SwissProt for SEPT10 Gene

Tissue specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines.
genes like me logo Genes that share expression patterns with SEPT10: view

Protein tissue co-expression partners for SEPT10 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SEPT10 Gene

Orthologs for SEPT10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPT10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEPT10 35
  • 88.42 (n)
  • 89.16 (a)
SEPT10 36
  • 88 (a)
(Canis familiaris)
Mammalia SEPT10 35
  • 91.34 (n)
  • 92.71 (a)
SEPT10 36
  • 85 (a)
(Mus musculus)
Mammalia Sept10 35
  • 85.81 (n)
  • 85.89 (a)
Sept10 16
Sept10 36
  • 85 (a)
(Pan troglodytes)
Mammalia SEPT10 35
  • 99.93 (n)
  • 99.78 (a)
(Rattus norvegicus)
Mammalia Sept10 35
  • 86.78 (n)
  • 86.7 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
-- 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SEPT10 36
  • 75 (a)
(Gallus gallus)
Aves SEPT10 35
  • 75.13 (n)
  • 75.13 (a)
SEPT10 36
  • 73 (a)
(Anolis carolinensis)
Reptilia SEPT10 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sept10 35
  • 71.44 (n)
  • 73.38 (a)
Str.6034 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7604 35
(Danio rerio)
Actinopterygii sept10 35
  • 72.33 (n)
  • 79.67 (a)
sept10 36
  • 77 (a)
sept10 36
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
Species with no ortholog for SEPT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT10 Gene

Gene Tree for SEPT10 (if available)
Gene Tree for SEPT10 (if available)

Paralogs for SEPT10 Gene

Paralogs for SEPT10 Gene Pseudogenes for SEPT10 Gene

genes like me logo Genes that share paralogs with SEPT10: view

Variants for SEPT10 Gene

Sequence variations from dbSNP and Humsavar for SEPT10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3829701 - 109,574,615(-) GACAC(C/T)TGATC intron-variant, nc-transcript-variant, reference, missense
rs717188 -- 109,571,024(-) GCAAG(A/G)GACAA intron-variant
rs717189 -- 109,571,282(-) AGTCC(A/G)TTCTC intron-variant
rs747445 -- 109,595,096(+) TGGCC(A/G)GGGTG intron-variant
rs753492 -- 109,591,085(+) gtaca(C/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT10 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv2874 CNV Loss 18451855
nsv510884 CNV Complex 20534489
nsv829617 CNV Gain 20364138
esv2657195 CNV Deletion 23128226

Variation tolerance for SEPT10 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEPT10 Gene

Disorders for SEPT10 Gene

Relevant External Links for SEPT10

Genetic Association Database (GAD)

No disorders were found for SEPT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPT10 Gene

Publications for SEPT10 Gene

  1. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. (PMID: 12711328) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. (PMID: 17657217) Benedetti D. … Gattei V. (Leukemia 2008) 3 23
  3. Surrogate molecular markers for IGHV mutational status in chronic lymphocytic leukemia for predicting time to first treatment. (PMID: 26038121) Morabito F. … Neri A. (Leuk. Res. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SEPT10 Gene

Sources for SEPT10 Gene