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Aliases for SEPT10 Gene

Aliases for SEPT10 Gene

  • Septin 10 2 3 5
  • Sept1-Like 2
  • Septin-10 3

External Ids for SEPT10 Gene

Previous GeneCards Identifiers for SEPT10 Gene

  • GC02M109850
  • GC02M109912
  • GC02M109657
  • GC02M110300
  • GC02M103756

Summaries for SEPT10 Gene

Entrez Gene Summary for SEPT10 Gene

  • This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for SEPT10 Gene

SEPT10 (Septin 10) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT8.

UniProtKB/Swiss-Prot for SEPT10 Gene

  • Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPT10 Gene

Genomics for SEPT10 Gene

Regulatory Elements for SEPT10 Gene

Enhancers for SEPT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F109605 1.1 Ensembl ENCODE 15.7 +3.0 2990 11.0 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS ZNF263 SEPT10 SOWAHC LINC00116 GPAA1P2 ENSG00000230696
GH02F109557 0.5 Ensembl ENCODE 14.1 +55.4 55365 2.1 MLX ARID4B DMAP1 YY1 SLC30A9 FOS MIER2 PPARG KAT8 MIER3 SEPT10 SOWAHC RPL37P12 GC02M109583
GH02F109635 1.3 FANTOM5 Ensembl ENCODE 14 -23.0 -23047 3.8 ELF3 MLX ARID4B DNMT3B RARA ETV6 ZNF548 CREM MIXL1 THAP11 SOWAHC SEPT10 RGPD6 GC02P109639
GH02F109630 0.5 Ensembl ENCODE 13.6 -17.5 -17515 2.9 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 PPARG KAT8 MIER3 ETV4 SEPT10 SOWAHC GC02P109639
GH02F109554 0.4 ENCODE 13.6 +59.0 58970 2.0 MEF2D MTA2 ATF3 IKZF1 TCF7 ZNF175 NFE2 SPI1 SEPT10 RPL37P12 GC02M109583
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SEPT10 on UCSC Golden Path with GeneCards custom track

Promoters for SEPT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000596305 -194 5201 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF263 SP3

Genomic Location for SEPT10 Gene

Chromosome:
2
Start:
109,542,797 bp from pter
End:
109,614,206 bp from pter
Size:
71,410 bases
Orientation:
Minus strand

Genomic View for SEPT10 Gene

Genes around SEPT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPT10 Gene

Proteins for SEPT10 Gene

  • Protein details for SEPT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0V9-SEP10_HUMAN
    Recommended name:
    Septin-10
    Protein Accession:
    Q9P0V9
    Secondary Accessions:
    • B3KRQ9
    • Q86VP5
    • Q9HAH6

    Protein attributes for SEPT10 Gene

    Size:
    454 amino acids
    Molecular mass:
    52593 Da
    Quaternary structure:
    • Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
    SequenceCaution:
    • Sequence=AAF67469.1; Type=Frameshift; Positions=444; Evidence={ECO:0000305};

    Alternative splice isoforms for SEPT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPT10 Gene

Post-translational modifications for SEPT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SEPT10

No data available for DME Specific Peptides for SEPT10 Gene

Domains & Families for SEPT10 Gene

Gene Families for SEPT10 Gene

Protein Domains for SEPT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0V9

UniProtKB/Swiss-Prot:

SEP10_HUMAN :
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Domain:
  • Contains 1 septin-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
genes like me logo Genes that share domains with SEPT10: view

No data available for Suggested Antigen Peptide Sequences for SEPT10 Gene

Function for SEPT10 Gene

Molecular function for SEPT10 Gene

UniProtKB/Swiss-Prot Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

Gene Ontology (GO) - Molecular Function for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SEPT10: view

Phenotypes for SEPT10 Gene

genes like me logo Genes that share phenotypes with SEPT10: view

Animal Models for SEPT10 Gene

MGI Knock Outs for SEPT10:

Animal Model Products

miRNA for SEPT10 Gene

miRTarBase miRNAs that target SEPT10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEPT10 Gene

Localization for SEPT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPT10 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Using a GFP-fusion protein, detected in the nucleus. {ECO:0000269 PubMed:12711328}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPT10 Gene COMPARTMENTS Subcellular localization image for SEPT10 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SEPT10: view

Pathways & Interactions for SEPT10 Gene

SuperPathways for SEPT10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEPT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SEPT10: view

No data available for Pathways by source and SIGNOR curated interactions for SEPT10 Gene

Drugs & Compounds for SEPT10 Gene

(1) Drugs for SEPT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SEPT10: view

Transcripts for SEPT10 Gene

Unigene Clusters for SEPT10 Gene

Septin 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPT10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6: - - - - - - - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - - - - - -
SP11: - -
SP12: - - - - - - - - -
SP13:

Relevant External Links for SEPT10 Gene

GeneLoc Exon Structure for
SEPT10
ECgene alternative splicing isoforms for
SEPT10

Expression for SEPT10 Gene

mRNA expression in normal human tissues for SEPT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEPT10 Gene



Protein tissue co-expression partners for SEPT10 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for SEPT10 Gene:

Hs.469615

mRNA Expression by UniProt/SwissProt for SEPT10 Gene:

Q9P0V9-SEP10_HUMAN
Tissue specificity: Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines.
genes like me logo Genes that share expression patterns with SEPT10: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SEPT10 Gene

Orthologs for SEPT10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPT10 34
  • 99.93 (n)
dog
(Canis familiaris)
Mammalia SEPT10 34 35
  • 91.34 (n)
cow
(Bos Taurus)
Mammalia SEPT10 34 35
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Sept10 34
  • 86.78 (n)
mouse
(Mus musculus)
Mammalia Sept10 34 16 35
  • 85.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SEPT10 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPT10 34 35
  • 75.13 (n)
lizard
(Anolis carolinensis)
Reptilia SEPT10 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sept10 34
  • 71.44 (n)
Str.6034 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7604 34
zebrafish
(Danio rerio)
Actinopterygii sept10 34 35 35
  • 72.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToMany
Species where no ortholog for SEPT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPT10 Gene

ENSEMBL:
Gene Tree for SEPT10 (if available)
TreeFam:
Gene Tree for SEPT10 (if available)

Paralogs for SEPT10 Gene

Variants for SEPT10 Gene

Sequence variations from dbSNP and Humsavar for SEPT10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1036317 -- 109,609,611(-) TGAGG(C/G/T)GGAGT intron-variant
rs1036318 -- 109,609,501(-) AGCCC(A/C)TGGCA intron-variant
rs10496431 -- 109,548,083(+) AGGAA(A/C)TACAG intron-variant
rs10496432 -- 109,570,061(+) AAATG(A/G)GCCAA intron-variant
rs10496433 -- 109,608,038(+) TAATT(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPT10 Gene

Variant ID Type Subtype PubMed ID
dgv1162e212 CNV gain 25503493
dgv4037n100 CNV gain 25217958
esv2657195 CNV deletion 23128226
esv2762780 CNV gain 21179565
esv3559936 CNV deletion 23714750
esv3591944 CNV gain 21293372
nsv1114125 CNV deletion 24896259
nsv1149522 OTHER inversion 26484159
nsv2874 CNV deletion 18451855
nsv510884 OTHER complex 20534489
nsv829617 CNV gain 20364138

Variation tolerance for SEPT10 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEPT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPT10 Gene

Disorders for SEPT10 Gene

Relevant External Links for SEPT10

Genetic Association Database (GAD)
SEPT10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEPT10

No disorders were found for SEPT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPT10 Gene

Publications for SEPT10 Gene

  1. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. (PMID: 12711328) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10. (PMID: 17657217) Benedetti D. … Gattei V. (Leukemia 2008) 3 22 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SEPT10 Gene

Sources for SEPT10 Gene

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