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Aliases for SEPP1 Gene

Aliases for SEPP1 Gene

  • Selenoprotein P, Plasma, 1 2 3
  • SELP 3 4
  • SEP 3 4
  • Selenoprotein P 3

External Ids for SEPP1 Gene

Previous GeneCards Identifiers for SEPP1 Gene

  • GC05M033155
  • GC05M043976
  • GC05M042799
  • GC05M042845

Summaries for SEPP1 Gene

Entrez Gene Summary for SEPP1 Gene

  • This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEPP1 Gene

SEPP1 (Selenoprotein P, Plasma, 1) is a Protein Coding gene. Diseases associated with SEPP1 include kashin-beck disease. Among its related pathways are Hemostasis and amb2 Integrin signaling. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for SEPP1 Gene

  • Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

Gene Wiki entry for SEPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPP1 Gene

Genomics for SEPP1 Gene

Regulatory Elements for SEPP1 Gene

Genomic Location for SEPP1 Gene

Start:
42,799,880 bp from pter
End:
42,887,392 bp from pter
Size:
87,513 bases
Orientation:
Minus strand

Genomic View for SEPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPP1 Gene

Proteins for SEPP1 Gene

  • Protein details for SEPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49908-SEPP1_HUMAN
    Recommended name:
    Selenoprotein P
    Protein Accession:
    P49908
    Secondary Accessions:
    • Q6PD59
    • Q6PI43
    • Q6PI87
    • Q6PJF9

    Protein attributes for SEPP1 Gene

    Size:
    381 amino acids
    Molecular mass:
    43174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEPP1 Gene

Proteomics data for SEPP1 Gene at MOPED

Post-translational modifications for SEPP1 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Glycosylation at Asn46, Asn83, Asn119, Asn128, Asn174, and Asn338
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEPP1 Gene

Domains for SEPP1 Gene

Protein Domains for SEPP1 Gene

Suggested Antigen Peptide Sequences for SEPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49908

UniProtKB/Swiss-Prot:

SEPP1_HUMAN :
  • P49908
Family:
  • Belongs to the selenoprotein P family.
genes like me logo Genes that share domains with SEPP1: view

No data available for Gene Families for SEPP1 Gene

Function for SEPP1 Gene

Molecular function for SEPP1 Gene

GENATLAS Biochemistry: selenoprotein P,heparin binding protein,associated to endothelial cells
UniProtKB/Swiss-Prot Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

Gene Ontology (GO) - Molecular Function for SEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IEA --
genes like me logo Genes that share ontologies with SEPP1: view
genes like me logo Genes that share phenotypes with SEPP1: view

Animal Models for SEPP1 Gene

MGI Knock Outs for SEPP1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SEPP1 Gene

Localization for SEPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPP1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for SEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SEPP1: view

No data available for Subcellular locations from COMPARTMENTS for SEPP1 Gene

Pathways for SEPP1 Gene

genes like me logo Genes that share pathways with SEPP1: view

Interacting Proteins for SEPP1 Gene

Gene Ontology (GO) - Biological Process for SEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IEA --
GO:0006979 response to oxidative stress TAS 2037562
GO:0007420 brain development IEA --
GO:0007626 locomotory behavior IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with SEPP1: view

Compounds for SEPP1 Gene

(2) HMDB Compounds for SEPP1 Gene

Compound Synonyms Cas Number PubMed IDs
Selenium
  • selenium
7782-49-2
Selenocysteine
  • (2R)-2-amino-3-selanylpropanoate
3614-08-2

(21) Novoseek inferred chemical compound relationships for SEPP1 Gene

Compound -log(P) Hits PubMed IDs
selenium 91.9 131
selenocysteine 90.7 14
selenomethionine 83.9 4
selenite 79.7 7
3-iodothyronine 75 1
genes like me logo Genes that share compounds with SEPP1: view

Transcripts for SEPP1 Gene

Unigene Clusters for SEPP1 Gene

Selenoprotein P, plasma, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEPP1 Gene

No ASD Table

Relevant External Links for SEPP1 Gene

GeneLoc Exon Structure for
SEPP1
ECgene alternative splicing isoforms for
SEPP1

Expression for SEPP1 Gene

mRNA expression in normal human tissues for SEPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPP1 Gene

This gene is overexpressed in Liver (6.9) and Brain - Spinal cord (cervical c-1) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEPP1 Gene

SOURCE GeneReport for Unigene cluster for SEPP1 Gene Hs.275775

mRNA Expression by UniProt/SwissProt for SEPP1 Gene

P49908-SEPP1_HUMAN
Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney
genes like me logo Genes that share expressions with SEPP1: view

Orthologs for SEPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPP1 35
  • 99.13 (n)
  • 98.16 (a)
cow
(Bos Taurus)
Mammalia SEPP1 35
  • 83.2 (n)
  • 75.07 (a)
dog
(Canis familiaris)
Mammalia SEPP1 35
  • 85.29 (n)
  • 78.34 (a)
SEPP1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sepp1 35
  • 77.78 (n)
  • 72.22 (a)
Sepp1 16
Sepp1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPP1 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPP1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sepp1 35
  • 79.32 (n)
  • 72.99 (a)
chicken
(Gallus gallus)
Aves SEPP1 35
  • 63.7 (n)
  • 54.31 (a)
SEPP1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEPP1 36
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28822 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sepp1 35
  • 61.3 (n)
  • 52.87 (a)
Str.5371 35
zebrafish
(Danio rerio)
Actinopterygii sepp1a 35
  • 51.34 (n)
  • 42.9 (a)
sepp1a 36
  • 31 (a)
OneToOne
Species with no ortholog for SEPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEPP1 Gene

ENSEMBL:
Gene Tree for SEPP1 (if available)
TreeFam:
Gene Tree for SEPP1 (if available)

Paralogs for SEPP1 Gene

No data available for Paralogs for SEPP1 Gene

Variants for SEPP1 Gene

Sequence variations from dbSNP and Humsavar for SEPP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs189124 -- 42,807,830(+) CCTCT(C/T)GTATT intron-variant
rs230817 -- 42,803,463(+) TAAAA(A/T)GTGAA intron-variant
rs230818 -- 42,804,120(+) TCTAA(A/G)GCTCT intron-variant
rs230819 -- 42,805,863(+) AAAAT(A/C)AAAGT intron-variant
rs230820 -- 42,807,322(+) GCTTA(A/C)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPP1 Gene

Variant ID Type Subtype PubMed ID
nsv462126 CNV Gain 19166990
nsv523033 CNV Gain 19592680

Relevant External Links for SEPP1 Gene

HapMap Linkage Disequilibrium report
SEPP1
Human Gene Mutation Database (HGMD)
SEPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPP1 Gene

Disorders for SEPP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SEPP1 Gene including...

Search for SEPP1 Gene in MalaCards »

(11) Novoseek inferred disease relationships for SEPP1 Gene

Disease -log(P) Hits PubMed IDs
selenium deficiency 86.8 3
hepatic necrosis 24.7 1
colon cancer 21.5 1
colorectal cancer 20.8 1
adenoma 15.9 9

Relevant External Links for SEPP1

Genetic Association Database (GAD)
SEPP1
Human Genome Epidemiology (HuGE) Navigator
SEPP1
genes like me logo Genes that share disorders with SEPP1: view

No data available for UniProtKB/Swiss-Prot for SEPP1 Gene

Publications for SEPP1 Gene

  1. Purification of selenoprotein P from human plasma. (PMID: 8142465) Aakesson B. … Burk R.F. (Biochim. Biophys. Acta 1994) 3 4 23
  2. Selenoprotein P: properties, functions, and regulation. (PMID: 10775431) Mostert V. (Arch. Biochem. Biophys. 2000) 3 4 23
  3. A novel method for the purification of selenoprotein P from human plasma. (PMID: 9735174) Mostert V. … Abel J. (Arch. Biochem. Biophys. 1998) 3 4 23
  4. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PMID: 7931697) Burk R.F. … Hill K.E. (J. Nutr. 1994) 3 4 23
  5. Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study). (PMID: 17536041) MAcplan C. … Hesketh J.E. (FASEB J. 2007) 3 23 48

Products for SEPP1 Gene

Sources for SEPP1 Gene

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