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SEPP1 Gene

protein-coding   GIFtS: 56
GCID: GC05M042799

Selenoprotein P, Plasma, 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenoprotein P, Plasma, 11 2
SELP2 3
SeP2 3
Selenoprotein P2

External Ids:    HGNC: 107511   Entrez Gene: 64142   Ensembl: ENSG000002507227   OMIM: 6014845   UniProtKB: P499083   

Export aliases for SEPP1 gene to outside databases

Previous GC identifers: GC05M033155 GC05M043976 GC05M042845 GC05M042835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPP1 Gene:
This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA
codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop
structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon
rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it
contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with
endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several
transcript variants, encoding either the same or different isoform, have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SEPP1 Gene:
SEPP1 (selenoprotein P, plasma, 1) is a protein-coding gene. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might
be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

summary for SEPP1 Gene:
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and
intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,
differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common
in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There
are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SEPP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPP1 gene promoter:
         SRY   FOXO4   FOXO1a   ATF6   GATA-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SEPP1 promoter sequence
   Search Chromatin IP Primers for SEPP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5q31

SEPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M042799:  view genomic region     (about GC identifiers)

Start:
42,799,982 bp from pter      End:
42,887,494 bp from pter
Size:
87,513 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908 (See protein sequence)
Recommended Name: Selenoprotein P precursor  
Size: 381 amino acids; 43174 Da
Secondary accessions: Q6PD59 Q6PI43 Q6PI87 Q6PJF9

Explore the universe of human proteins at neXtProt for SEPP1: NX_P49908

Explore proteomics data for SEPP1 at MOPED

Post-translational modifications: 

  • Phosphorylation sites are present in the extracellular medium1
  • Glycosylation2 at Asn46, Asn83, Asn119, Asn128, Asn174, Asn338

  • See SEPP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001078955.1  NP_001087195.1  NP_005401.3  

    ENSEMBL proteins: 
     ENSP00000420939   ENSP00000427671   ENSP00000425915   ENSP00000473340   ENSP00000421626  
     ENSP00000427414  

    SEPP1 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEPP1

     
    Search eBioscience for Proteins for SEPP1 

     
    antibodies-online proteins for SEPP1 (4 products) 

     
    antibodies-online peptides for SEPP1

    SEPP1 Antibody Products:

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    antibodies-online antibodies for SEPP1 (16 products) 

    SEPP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SEPP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEPP1
    Cloud-Clone Corp. CLIAs for SEPP1
    Search eBioscience for ELISAs for SEPP1 
    antibodies-online kits for SEPP1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007672 SelP_C
     IPR007671 Selenoprotein-P_N

    Graphical View of Domain Structure for InterPro Entry P49908

    ProtoNet protein and cluster: P49908

    1 Blocks protein domain: IPB007671 Selenoprotein P

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Similarity: Belongs to the selenoprotein P family


    Find genes that share domains with SEPP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPP1_HUMAN, P49908
    Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might
    be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

         Genatlas biochemistry entry for SEPP1:
    selenoprotein P,heparin binding protein,associated to endothelial cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008430selenium binding IEA--
         
    Find genes that share ontologies with SEPP1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sepp1):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 

    Find genes that share phenotypes with SEPP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sepp1tm1Rfb for SEPP1

       genOway: Develop your customized and physiologically relevant rodent model for SEPP1

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    1 qRT-PCR Assays for microRNA that regulate SEPP1:
    hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSEPP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SEPP1
    Predesigned siRNA for gene silencing in human, mouse, rat SEPP1

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SEPP1 (NM_005410)
    Sino Biological Human cDNA Clone for SEPP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPP1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12396) for SEPP1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEPP1_HUMAN, P49908: Secreted

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with SEPP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Integrin-mediated cell adhesion0.38
    2Selenium Pathway
    Selenium Pathway
    3Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    3 BioSystems Pathways for SEPP1
        Integrin-mediated cell adhesion
    Selenium Metabolism and Selenoproteins
    Selenium Pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including SEPP1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SEPP1

    5 Interacting proteins for SEPP1 (P499082, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005333I2D: score=2 
    PTK2Q053973I2D: score=2 
    THRAP108273I2D: score=1 
    --P032042MINT-6771120
    --P0C7232MINT-6770581
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001887selenium compound metabolic process IEA--
    GO:0006979response to oxidative stress TAS2037562
    GO:0007420brain development IEA--
    GO:0007626locomotory behavior IEA--
    GO:0009791post-embryonic development IEA--

    Find genes that share ontologies with SEPP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SEPP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    2 HMDB Compounds for SEPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    Selected Novoseek inferred chemical compound relationships for SEPP1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 91.9 218 8558294 (6), 19747622 (6), 9846591 (6), 16011466 (5) (see all 73)
    selenocysteine 90.7 26 18377657 (5), 15117283 (2), 11683552 (1), 16286677 (1) (see all 9)
    selenomethionine 83.9 9 15817859 (1), 16632112 (1), 19034261 (1), 20181815 (1)
    selenite 79.7 8 12896980 (1), 15817859 (1), 17015273 (1), 16757516 (1) (see all 7)
    3-iodothyronine 75 1 10405682 (1)
    selenol 73.7 1 9743246 (1)
    selenophosphate 71.5 2 15634611 (1), 18790070 (1)
    deae 49.5 1 8846159 (1)
    peroxynitrite 36.7 9 9792455 (3), 15104205 (2), 10775431 (1), 10927168 (1) (see all 5)
    tert-butylhydroperoxide 35.7 7 16632112 (3), 17015273 (1)



    Find genes that share compounds with SEPP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEPP1 gene (3 alternative transcripts): 
    NM_001085486.1  NM_001093726.1  NM_005410.2  

    Unigene Cluster for SEPP1:

    Selenoprotein P, plasma, 1
    Hs.275775  [show with all ESTs]
    Unigene Representative Sequence: BC030009
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43):
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000512980 ENST00000511224 ENST00000511224 ENST00000511224 ENST00000511224
    ENST00000511224 ENST00000511224 ENST00000511224
    miRNA
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    Block miRNA regulation of human, mouse, rat SEPP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SEPP1:
    hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSEPP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SEPP1
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    GenScript: all cDNA clones in your preferred vector (see all 3): SEPP1 (NM_005410)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SEPP1
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      QuantiFast Probe-based Assays in human, mouse, rat SEPP1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12396) for SEPP1 

    Additional mRNA sequence: 

    AK096125.1 AK225801.1 AK311392.1 AL833145.1 BC005244.1 BC015875.1 BC030009.1 BC040075.1 
    BC046152.1 BC058919.1 Z11793.1 

    Selected DOTS entries (see all 53):

    DT.91777246  DT.95378911  DT.92019418  DT.91897657  DT.95373331  DT.100891828  DT.120812338  DT.100039549 
    DT.101985516  DT.100688257  DT.91777226  DT.100891824  DT.97864852  DT.92013200  DT.120812243  DT.92044737 
    DT.120812317  DT.100891814  DT.95373296  DT.100891827  DT.120812319  DT.120812321  DT.91777248  DT.100891829 

    Selected AceView cDNA sequences (see all 1047):

    BM784443 AA676534 AA334007 BP344823 AI913139 BG617566 AA604176 AI979233 
    AL537857 BM511491 AA377146 AI151234 BX439645 BX382950 BP379058 CB266729 
    BP345933 CA431803 BQ718520 BM768554 AL531331 BM874311 AA680396 AU137297 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGCCT
    SEPP1 Expression
    About this image


    SEPP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
    SEPP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.275775

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEPP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sepp11 , 5 selenoprotein P, plasma, 11, 5 77.78(n)1
    72.22(a)1
      15 (1.84 cM)5
    203631  NM_001042613.11  NP_001036078.11 
     32685475 
    chicken
    (Gallus gallus)
    Aves SEPP11 selenoprotein P, plasma, 1 63.7(n)
    54.31(a)
      431587  NM_001031609.2  NP_001026780.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEPP16
    selenoprotein P, plasma, 1
    42(a)
    1 ↔ 1
    4(110208739-110211018)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.288222 Xenopus laevis cDNA clone IMAGE6877969, partial cds 75.55(n)    BC054205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sepp1a1 selenoprotein P, plasma, 1a 51.34(n)
    42.9(a)
      352931  NM_178297.3  NP_840082.2 


    ENSEMBL Gene Tree for SEPP1 (if available)
    TreeFam Gene Tree for SEPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPP1 (see all 232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289199141,2
    C,F--42803062(-) AAATA-/ATGCAT 3 -- int15Minor allele frequency- A:0.28NS 190
    rs1157631911,2
    C,F--42803230(+) AAACTC/TCAATC 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1820881761,2
    --42803374(+) GCATTC/TGCACA 3 -- int10--------
    rs289199131,2
    C,F--42803428(-) AATACT/CAATTA 3 -- int114Minor allele frequency- C:0.27NS NA WA CSA 436
    rs2308171,2
    C,F,H--42803565(+) TAAAAT/AGTGAA 3 -- int19Minor allele frequency- A:0.00NS EA 602
    rs1412315991,2
    --42803648(+) GAGGCA/GGCTTT 3 -- int10--------
    rs168727771,2
    C,F,H--42803821(+) ATTAAA/GTTCTT 3 -- int113Minor allele frequency- G:0.05NA NS EA 864
    rs119594661,2
    C,F,H--42803824(+) AAATTC/TTTTGA 3 -- int110Minor allele frequency- T:0.03NS EA NA 722
    rs289199121,2
    C--42803913(-) CTGGTA/GTTTAT 3 -- int15Minor allele frequency- G:0.01NS 186
    rs1469731621,2
    --42803921(+) CAGTAA/GTGAGT 3 -- int10--------

    HapMap Linkage Disequilibrium report for SEPP1 (42799982 - 42887494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEPP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523033CNV Gain19592680
    nsv462126CNV Gain19166990

    Human Gene Mutation Database (HGMD): SEPP1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SEPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601484    OMIM disorders: --


    Find genes that share disorders with SEPP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SEPP1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 86.8 5 19034261 (2), 16011466 (1)
    hepatic necrosis 24.7 1 7931697 (1)
    colon cancer 21.5 1 15203372 (1)
    colorectal cancer 20.8 2 18054426 (1)
    adenoma 15.9 15 18483336 (5), 10965527 (3), 12173025 (1)
    cancer 8.68 12 10798212 (5), 19327385 (2), 16131327 (1), 20181815 (1) (see all 5)
    necrosis 0 4 12878326 (1), 10571054 (1)
    cirrhosis 0 2 16011466 (1), 9500709 (1)
    neurodegenerative diseases 0 2 20521393 (1)
    hepatocellular carcinoma 0 1 9361018 (1)

    Genetic Association Database (GAD): SEPP1
    Human Genome Epidemiology (HuGE) Navigator: SEPP1 (18 documents)

    Export disorders for SEPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPP1 gene, integrated from 10 sources (see all 190):
    (articles sorted by number of sources associating them with SEPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. (PubMed id 8421687)1, 2, 3 Hill K.E.... Burk R.F. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PubMed id 18483336)1, 4, 9 Peters U....Foster C.B. (amp 2008)
    3. Selenoprotein P: properties, functions, and regulation. (PubMed id 10775431)1, 2, 9 Mostert V. (Arch. Biochem. Biophys. 2000)
    4. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PubMed id 7931697)1, 2, 9 Burk R.F. and Hill K.E. (J. Nutr. 1994)
    5. Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status. (PubMed id 19453253)1, 4, 9 MAcplan C....Hesketh J.E. (amp 2009)
    6. Purification of selenoprotein P from human plasma. (PubMed id 8142465)1, 2, 9 Aakesson B.... Burk R.F. (Biochim. Biophys. Acta 1994)
    7. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PubMed id 20378690)1, 4, 9 MAcplan C....Hesketh J.E. (Carcinogenesis 2010)
    8. Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk. (PubMed id 19074884)1, 4, 9 Cooper M.L....Rayman M.P. (Cancer Res. 2008)
    9. A novel method for the purification of selenoprotein P from human plasma. (PubMed id 9735174)1, 2, 9 Mostert V.... Abel J. (Arch. Biochem. Biophys. 1998)
    10. Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. (PubMed id 20178852)1, 4, 9 Xiong Y.M....Zang W.J. (Osteoarthr. Cartil. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6414 HGNC: 10751 AceView: SEPP1 Ensembl:ENSG00000250722 euGenes: HUgn6414
    ECgene: SEPP1 H-InvDB: SEPP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sepp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPP1 gene:
    Search GeneIP for patents involving SEPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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