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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPP1 Gene

protein-coding   GIFtS: 56
GCID: GC05M042835

selenoprotein P, plasma, 1
 Explore 35 diseases affiliated with
SEPP1 via
MalaCards
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 Human Malady Compendium 
Biological research products
for SEPP1    

Aliases
for SEPP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Selenoprotein P, Plasma, 11 2
SeP1 2 3
SELP2 3
Selenoprotein P2

External Ids:    HGNC: 107511   Entrez Gene: 64142   Ensembl: ENSG000002507227   OMIM: 6014845   UniProtKB: P499083   

Export aliases for SEPP1 gene to outside databases

Previous GC identifers: GC05M033155 GC05M043976 GC05M042799 GC05M042845


Summaries
for SEPP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEPP1:
This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon
that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure,
the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop
signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per
polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been
implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the
same or different isoform, have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be
involved in the transport of selenium. May supply selenium to tissues such as brain and testis

summary for SEPP1:
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and
intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,
differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common
in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There
are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SEPP1


Genomic Views
for SEPP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPP1 gene promoter:
         SRY   FOXO4   FOXO1a   ATF6   GATA-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SEPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5q31

SEPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M042835:  view genomic region     (about GC identifiers)

Start:
 42,799,982 bp from pter      End:
 42,887,494 bp from pter
Size:
 87,513 bases      Orientation:
 minus strand

Proteins
for SEPP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908 (See protein sequence)
Recommended Name: Selenoprotein P precursor  
Size: 381 amino acids; 43174 Da
Subcellular location: Secreted
Secondary accessions: Q6PD59 Q6PI43 Q6PI87 Q6PJF9

Explore the universe of human proteins at neXtProt for SEPP1: NX_P49908

Post-translational modifications:

  • Phosphorylation sites are present in the extracellular medium1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49908

    • SEPP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001078955.1  NP_001087195.1  NP_005401.3  

    ENSEMBL proteins: 
     ENSP00000420939   ENSP00000427671   ENSP00000425915   ENSP00000421626   ENSP00000427414  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SEPP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--


    SEPP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SEPP1

    Protein Domains /
    Families
    for SEPP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEPP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007671 Selenoprotein-P_N
     IPR007672 SelP_C

    Graphical View of Domain Structure for InterPro Entry P49908

    ProtoNet protein and cluster: P49908

    1 Blocks protein family: IPB007671 Selenoprotein P

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Similarity: Belongs to the selenoprotein P family


    Function
    for SEPP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be
    involved in the transport of selenium. May supply selenium to tissues such as brain and testis

         Genatlas biochemistry entry for SEPP1:
    selenoprotein P,heparin binding protein,associated to endothelial cells

    miRNA
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    hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SEPP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPP1 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008430selenium binding IEA--


    SEPP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Sepp1tm1Rfb for SEPP1
         10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sepp1):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 

    SEPP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SEPP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selenium Metabolism and Selenoproteins
    		Selenium Metabolism and Selenoproteins1.00
    2Selenium Pathway
    		Selenium Pathway1.00
    3Focal Adhesion
    		Integrin-mediated cell adhesion0.38


    3 BioSystems Pathways for SEPP1 
        Integrin-mediated cell adhesion
    Selenium Metabolism and Selenoproteins
    Selenium Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPP1

    5 Interacting proteins for SEPP1 (P499082, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005333I2D: score=2 
    PTK2Q053973I2D: score=2 
    THRAP108273I2D: score=1 
    --P032042MINT-6771120
    --P0C7232MINT-6770581
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001887selenium compound metabolic process IEA--
    GO:0006979response to oxidative stress TAS2037562
    GO:0007420brain development IEA--
    GO:0007626locomotory behavior IEA--
    GO:0009791post-embryonic development IEA--


    SEPP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEPP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SEPP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KF 38789Selective inhibitor of P-selectin-mediated cell adhesion[257292-29-8]

    2 HMDB Compounds for SEPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--
    10/21 Novoseek chemical compound relationships for SEPP1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 91.9 218 8558294 (6), 19747622 (6), 9846591 (6), 16011466 (5) (see all 73)
    selenocysteine 90.7 26 18377657 (5), 15117283 (2), 11683552 (1), 16286677 (1) (see all 9)
    selenomethionine 83.9 9 15817859 (1), 16632112 (1), 19034261 (1), 20181815 (1)
    selenite 79.7 8 12896980 (1), 15817859 (1), 17015273 (1), 16757516 (1) (see all 7)
    3-iodothyronine 75 1 10405682 (1)
    selenol 73.7 1 9743246 (1)
    selenophosphate 71.5 2 15634611 (1), 18790070 (1)
    deae 49.5 1 8846159 (1)
    peroxynitrite 36.7 9 9792455 (3), 15104205 (2), 10775431 (1), 10927168 (1) (see all 5)
    tert-butylhydroperoxide 35.7 7 16632112 (3), 17015273 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPP1 

    Transcripts
    for SEPP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEPP1 gene (3 alternative transcripts): 
    NM_001085486.1  NM_001093726.1  NM_005410.2  

    Unigene Clusters for SEPP1:

    Selenoprotein P, plasma, 1
    Hs.275775  [show with all ESTs], Hs.743272  [show with all ESTs]
    Unigene Representative Sequences: NM_001134848, BC030009
    18/43 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43):
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000512980 ENST00000511224 ENST00000511224 ENST00000511224 ENST00000511224
    ENST00000511224 ENST00000511224 ENST00000511224

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    hsa-miR-3148
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK096125.1 AK225801.1 AK311392.1 AL833145.1 BC005244.1 BC015875.1 BC030009.1 BC040075.1 
    BC046152.1 BC058919.1 Z11793.1 

    24/56 DOTS entries (see all 56):

    DT.95378911  DT.91777246  DT.92019418  DT.91897657  DT.95373331  DT.100891828  DT.100039549  DT.120812338 
    DT.101985516  DT.100688257  DT.91777226  DT.100891824  DT.97864852  DT.92013200  DT.120812243  DT.92044737 
    DT.120812317  DT.100891814  DT.95373296  DT.100891827  DT.120812319  DT.120812321  DT.91777248  DT.100673579 

    24/1047 AceView cDNA sequences (see all 1047):

    CR607105 BE719089 CA414422 AW172972 BQ573752 CA388975 CD514949 BM784443 
    BP378624 AI283367 BP378454 BP379284 CD517717 CA391793 AA676534 BC040075 
    CD516688 CA406832 BX480370 CB135633 CD675872 AA954870 AI381257 BP375322 

    GeneLoc Exon Structure


    Expression
    for SEPP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAAGCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SEPP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Alveolar type II cells (Derivation of mature...)Lung
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SEPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPP1

    SOURCE GeneReport for Unigene clusters: Hs.275775 Hs.743272

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including SEPP1: 
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              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SEPP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SEPP1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sepp11 , 5 selenoprotein P, plasma, 11, 5 77.6(n)1
    72.22(a)1    		   15 (1.84 cM)5
    203631  NM_001042613.11  NP_001036078.11 
     32685475 
    chicken
    (Gallus gallus)    		 Aves SEPP11 selenoprotein P, plasma, 1 63.61(n)
    55.01(a)    		   431587  NM_001031609.2  NP_001026780.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SEPP16
    		 --
    		 72(a)
    		 1 ↔ 1
    		 2(6258337-6258510)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.288222 Xenopus laevis cDNA clone IMAGE6877969, partial cds 75.55(n)    BC054205.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sepp1a1 selenoprotein P, plasma, 1a 50.34(n)
    43.11(a)    		   352931  NM_178297.3  NP_840082.2 


    ENSEMBL Gene Tree for SEPP1 (if available)
    TreeFam Gene Tree for SEPP1 (if available) 

    Paralogs
    for SEPP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SEPP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 NCBI SNPs in SEPP1 are shown (see all 242)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1882065011,2
    		--42799671(+) TACCAA/GTAGCA 4 -- ds5001 int10--------
    rs40414621,2
    		C,--42799719(-) AATAA-/TAAAATTT 4 -- ds5001 int10--------
    rs1931970691,2
    		--42799738(+) CTAATA/GACAAA 4 -- int1 ds50010--------
    rs289199291,2
    		F--42799744(-) GAAACAAA/-AAATT 4 -- ds5001 int15Minor allele frequency- -:0.02NS 188
    rs1497515181,2
    		C,--42799744(+) ACAAA-/TTTTTTGT 4 -- int1 ds50010--------
    rs1155165611,2
    		--42799882(+) GTTTTG/AAGCTT 5 /* syn1 ds50011Minor allele frequency- A:0.01NA 120
    rs168727621,2
    		C,F,H,--42799925(+) AAGCAA/GTCGAA 4 -- ds5001 ut3123Minor allele frequency- G:0.05NA NS EA EU 2393
    rs289199281,2
    		C--42799977(-) ACTTCG/ATTTGT 4 -- ut31 ds50015Minor allele frequency- A:0.01NS 188
    rs1487243691,2
    		--42800000(+) TTTTAC/TTGAAT 4 -- ut310--------
    rs49870171,2
    		C,F,H,--42800004(-) ATAAYT/CTCAAT 4 -- ut3122Minor allele frequency- C:0.05MN NS EA NA WA 1942

    HapMap Linkage Disequilibrium report for SEPP1 (42799982 - 42887494 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEPP1: --
    Human Gene Mutation Database (HGMD): SEPP1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SEPP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEPP1 for disorders           About GeneDecksing

    OMIM gene information: 601484    OMIM disorders: --

    20/35 diseases for SEPP1 (see all 35):    About MalaCards
    thyroid hormone metabolism    idiopathic pulmonary fibrosis    pulmonary fibrosis    neurodegenerative disease
    insulin resistance    autoimmune thyroiditis    celiac disease    hepatocellular carcinoma
    fibrosis    colorectal cancer    brain disease    lung cancer
    gastric adenocarcinoma    hepatitis b    pulmonary disease    thyroiditis
    adenoma    alzheimer's disease    infertility    blindness

    10/11 Novoseek disease relationships for SEPP1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 86.8 5 19034261 (2), 16011466 (1)
    hepatic necrosis 24.7 1 7931697 (1)
    colon cancer 21.5 1 15203372 (1)
    colorectal cancer 20.8 2 18054426 (1)
    adenoma 15.9 15 18483336 (5), 10965527 (3), 12173025 (1)
    cancer 8.68 12 10798212 (5), 19327385 (2), 16131327 (1), 20181815 (1) (see all 5)
    necrosis 0 4 12878326 (1), 10571054 (1)
    cirrhosis 0 2 16011466 (1), 9500709 (1)
    neurodegenerative diseases 0 2 20521393 (1)
    hepatocellular carcinoma 0 1 9361018 (1)

    Genetic Association Database (GAD): SEPP1
    Human Genome Epidemiology (HuGE) Navigator: SEPP1 (18 documents)

    Export disorders for SEPP1 gene to outside databases

    Publications
    for SEPP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPP1 gene, integrated from 9 sources (see all 180):
    (articles sorted by number of sources associating them with SEPP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. (PubMed id 8421687)1, 2, 3 Hill K.E.... Burk R.F. (1993)
    2. Selenoprotein P: properties, functions, and regulation. (PubMed id 10775431)1, 2, 9 Mostert V. (2000)
    3. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PubMed id 7931697)1, 2, 9 Burk R.F. and Hill K.E. (1994)
    4. Purification of selenoprotein P from human plasma. (PubMed id 8142465)1, 2, 9 Aakesson B.... Burk R.F. (1994)
    5. A novel method for the purification of selenoprotein P from human plasma. (PubMed id 9735174)1, 2, 9 Mostert V.... Abel J. (1998)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. (PubMed id 11280803)1, 4 Hu Y.J....Diamond A.M. (2001)
    9. Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p. (PubMed id 9915822)1, 9 Saito Y....Takahashi K. (1999)
    10. Role of selenoprotein P in Alzheimer's disease. (PubMed id 20521393)1, 9 Takemoto A.S....Bellinger F.P. (2010)

    External Searches for SEPP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SEPP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6414 HGNC: 10751 AceView: SEPP1 Ensembl:ENSG00000250722 euGenes: HUgn6414
    ECgene: SEPP1 H-InvDB: SEPP1

    Other Databases showing SEPP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SEPP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPP1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sepp1/

    Intellectual Property
    for SEPP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEPP1 gene:
    Search GeneIP for patents involving SEPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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