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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPP1 Gene

protein-coding   GIFtS: 58
GCID: GC05M042835

Selenoprotein P, Plasma, 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selenoprotein P, Plasma, 11 2
SELP2 3
SeP2 3
Selenoprotein P2

External Ids:    HGNC: 107511   Entrez Gene: 64142   Ensembl: ENSG000002507227   OMIM: 6014845   UniProtKB: P499083   

Export aliases for SEPP1 gene to outside databases

Previous GC identifers: GC05M033155 GC05M043976 GC05M042799 GC05M042845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPP1 Gene:
This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA
codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop
structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon
rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it
contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with
endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several
transcript variants, encoding either the same or different isoform, have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SEPP1 Gene: 
SEPP1 (selenoprotein P, plasma, 1) is a protein-coding gene. Diseases associated with SEPP1 include idiopathic pulmonary fibrosis, and autoimmune thyroiditis, and among its related super-pathways are Focal Adhesion. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might
be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

summary for SEPP1 Gene:
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and
intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,
differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common
in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There
are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SEPP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPP1 gene promoter:
         SRY   FOXO4   FOXO1a   ATF6   GATA-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SEPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5q31

SEPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M042835:  view genomic region     (about GC identifiers)

Start:
42,799,982 bp from pter      End:
42,887,494 bp from pter
Size:
87,513 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908 (See protein sequence)
Recommended Name: Selenoprotein P precursor  
Size: 381 amino acids; 43174 Da
Subcellular location: Secreted
Secondary accessions: Q6PD59 Q6PI43 Q6PI87 Q6PJF9

Explore the universe of human proteins at neXtProt for SEPP1: NX_P49908

Explore proteomics data for SEPP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49908

  • SEPP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEPP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001078955.1  NP_001087195.1  NP_005401.3  

    ENSEMBL proteins: 
     ENSP00000420939   ENSP00000427671   ENSP00000425915   ENSP00000473340   ENSP00000421626  
     ENSP00000427414  

    Human Recombinant Protein Products for SEPP1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEPP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--

    SEPP1 for ontologies           About GeneDecksing



    SEPP1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for SEPP1 
    Cloud-Clone Corp. CLIAs for SEPP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007671 Selenoprotein-P_N
     IPR007672 SelP_C

    Graphical View of Domain Structure for InterPro Entry P49908

    ProtoNet protein and cluster: P49908

    1 Blocks protein domain: IPB007671 Selenoprotein P

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Similarity: Belongs to the selenoprotein P family


    SEPP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPP1_HUMAN, P49908
    Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might
    be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

         Genatlas biochemistry entry for SEPP1:
    selenoprotein P,heparin binding protein,associated to endothelial cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008430selenium binding IEA--
         
    SEPP1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sepp1):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 

    SEPP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sepp1tm1Rfb for SEPP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPP1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SEPP1:
    hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSEPP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Sino Biological Human cDNA Clone for SEPP1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEPP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Integrin-mediated cell adhesion0.38
    2Selenium Pathway
    Selenium Pathway
    3Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    3 BioSystems Pathways for SEPP1
        Integrin-mediated cell adhesion
    Selenium Metabolism and Selenoproteins
    Selenium Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPP1

    5 Interacting proteins for SEPP1 (P499082, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005333I2D: score=2 
    PTK2Q053973I2D: score=2 
    THRAP108273I2D: score=1 
    --P032042MINT-6771120
    --P0C7232MINT-6770581
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001887selenium compound metabolic process IEA--
    GO:0006979response to oxidative stress TAS2037562
    GO:0007420brain development IEA--
    GO:0007626locomotory behavior IEA--
    GO:0009791post-embryonic development IEA--

    SEPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SEPP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    2 HMDB Compounds for SEPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    10/21 Novoseek inferred chemical compound relationships for SEPP1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 91.9 218 8558294 (6), 19747622 (6), 9846591 (6), 16011466 (5) (see all 73)
    selenocysteine 90.7 26 18377657 (5), 15117283 (2), 11683552 (1), 16286677 (1) (see all 9)
    selenomethionine 83.9 9 15817859 (1), 16632112 (1), 19034261 (1), 20181815 (1)
    selenite 79.7 8 12896980 (1), 15817859 (1), 17015273 (1), 16757516 (1) (see all 7)
    3-iodothyronine 75 1 10405682 (1)
    selenol 73.7 1 9743246 (1)
    selenophosphate 71.5 2 15634611 (1), 18790070 (1)
    deae 49.5 1 8846159 (1)
    peroxynitrite 36.7 9 9792455 (3), 15104205 (2), 10775431 (1), 10927168 (1) (see all 5)
    tert-butylhydroperoxide 35.7 7 16632112 (3), 17015273 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEPP1 gene (3 alternative transcripts): 
    NM_001085486.1  NM_001093726.1  NM_005410.2  

    Unigene Clusters for SEPP1:

    Selenoprotein P, plasma, 1
    Hs.275775  [show with all ESTs], Hs.745017  [show with all ESTs]
    Unigene Representative Sequences: BC030009, NM_001134848
    18/43 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43):
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000514985(uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2 uc011cps.2 uc011cpt.2 uc011cpu.2)
    ENST00000512980 ENST00000511224 ENST00000511224 ENST00000511224 ENST00000511224
    ENST00000511224 ENST00000511224 ENST00000511224

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SEPP1:
    hsa-miR-3148
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK094640.1 AK127368.1 AK303469.1 AY947526.1 BC015985.1 BC039102.1 

    24/56 DOTS entries (see all 56):

    DT.95378911  DT.91777246  DT.92019418  DT.91897657  DT.95373331  DT.100891828  DT.100039549  DT.101985516 
    DT.120812338  DT.100688257  DT.91777226  DT.100891824  DT.97864852  DT.92013200  DT.120812243  DT.92044737 
    DT.120812317  DT.100891814  DT.95373296  DT.100891827  DT.120812319  DT.120812321  DT.91777248  DT.100673579 

    24/1047 AceView cDNA sequences (see all 1047):

    AA954870 CA407707 CA391796 CA407146 AA334007 AI381257 BX463558 AV708196 
    BP345496 BM768554 BX480370 CA406832 CD242857 BP345778 BX439645 BP379071 
    BP346456 AU138086 AW151787 BG617566 N91230 CA388975 AU136519 BG186646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPP1 expression in normal human tissues (normalized intensities)      SEPP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGCCT
    SEPP1 Expression
    About this image


    SEPP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Peripheral blood-derived early endothelial progenitor cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Brain Pericytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
             Human Calvarial Osteoblasts (HCO)   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Line H9 (WA09)
     
     Fibroblast
             Human Pulmonary Fibroblasts (HPF)   

    See SEPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPP1

    SOURCE GeneReport for Unigene clusters: Hs.275775 Hs.745017

    UniProtKB/Swiss-Prot: SEPP1_HUMAN, P49908
    Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including SEPP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEPP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sepp11 , 5 selenoprotein P, plasma, 11, 5 77.6(n)1
    72.22(a)1
      15 (1.84 cM)5
    203631  NM_001042613.11  NP_001036078.11 
     32685475 
    chicken
    (Gallus gallus)
    Aves SEPP11 selenoprotein P, plasma, 1 63.61(n)
    55.01(a)
      431587  NM_001031609.2  NP_001026780.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEPP16
    Uncharacterized protein
    72(a)
    1 ↔ 1
    2(6258337-6258510)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.288222 Xenopus laevis cDNA clone IMAGE6877969, partial cds 75.55(n)    BC054205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sepp1a1 selenoprotein P, plasma, 1a 50.34(n)
    43.11(a)
      352931  NM_178297.3  NP_840082.2 


    ENSEMBL Gene Tree for SEPP1 (if available)
    TreeFam Gene Tree for SEPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/232 SNPs in SEPP1 are shown (see all 232)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0232604
    ----see VAR_0232602 R C mis40--------
    VAR_0232584
    ----see VAR_0232582 R Q mis40--------
    VAR_0232594
    ----see VAR_0232592 S P mis40--------
    VAR_0232574
    ----see VAR_0232572 A T mis40--------
    rs289199141,2
    C,F--42803062(-) AAATA-/ATGCAT 3 -- int15Minor allele frequency- A:0.28NS 190
    rs1157631911,2
    C,F--42803230(+) AAACTC/TCAATC 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1820881761,2
    --42803374(+) GCATTC/TGCACA 3 -- int10--------
    rs289199131,2
    C,F--42803428(-) AATACT/CAATTA 3 -- int114Minor allele frequency- C:0.27NS NA WA CSA 436
    rs2308171,2
    C,F,H--42803565(+) TAAAAT/AGTGAA 3 -- int19Minor allele frequency- A:0.00NS EA 602
    rs1412315991,2
    --42803648(+) GAGGCA/GGCTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for SEPP1 (42799982 - 42887494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEPP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523033CNV Gain19592680
    nsv462126CNV Gain19166990


    Human Gene Mutation Database (HGMD): SEPP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601484    OMIM disorders: --

    20/29 diseases for SEPP1 (see all 29):    About MalaCards
    idiopathic pulmonary fibrosis    autoimmune thyroiditis    endotheliitis    pulmonary fibrosis
    brain disease    gastric adenocarcinoma    celiac disease    blindness
    malaria    colorectal cancer    infertility    insulin resistance
    thyroiditis    adenoma    hepatitis    ischemia
    atherosclerosis    hepatitis b    pancreatic cancer    schizophrenia


    SEPP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for SEPP1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 86.8 5 19034261 (2), 16011466 (1)
    hepatic necrosis 24.7 1 7931697 (1)
    colon cancer 21.5 1 15203372 (1)
    colorectal cancer 20.8 2 18054426 (1)
    adenoma 15.9 15 18483336 (5), 10965527 (3), 12173025 (1)
    cancer 8.68 12 10798212 (5), 19327385 (2), 16131327 (1), 20181815 (1) (see all 5)
    necrosis 0 4 12878326 (1), 10571054 (1)
    cirrhosis 0 2 16011466 (1), 9500709 (1)
    neurodegenerative diseases 0 2 20521393 (1)
    hepatocellular carcinoma 0 1 9361018 (1)

    Genetic Association Database (GAD): SEPP1
    Human Genome Epidemiology (HuGE) Navigator: SEPP1 (18 documents)

    Export disorders for SEPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPP1 gene, integrated from 9 sources (see all 183):
    (articles sorted by number of sources associating them with SEPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. (PubMed id 8421687)1, 2, 3 Hill K.E.... Burk R.F. (1993)
    2. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PubMed id 18483336)1, 4, 9 Peters U....Foster C.B. (2008)
    3. Selenoprotein P: properties, functions, and regulation. (PubMed id 10775431)1, 2, 9 Mostert V. (2000)
    4. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PubMed id 7931697)1, 2, 9 Burk R.F. and Hill K.E. (1994)
    5. Relative abundance of selenoprotein P isoforms in hum an plasma depends on genotype, se intake, and cancer status. (PubMed id 19453253)1, 4, 9 MAcplan C....Hesketh J.E. (2009)
    6. Purification of selenoprotein P from human plasma. (PubMed id 8142465)1, 2, 9 Aakesson B.... Burk R.F. (1994)
    7. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PubMed id 20378690)1, 4, 9 MAcplan C....Hesketh J.E. (2010)
    8. Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk. (PubMed id 19074884)1, 4, 9 Cooper M.L....Rayman M.P. (2008)
    9. A novel method for the purification of selenoprotein P from human plasma. (PubMed id 9735174)1, 2, 9 Mostert V.... Abel J. (1998)
    10. Association study between polymorphisms in selenoprot ein genes and susceptibility to Kashin-Beck disease. (PubMed id 20178852)1, 4, 9 Xiong Y.M....Zang W.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6414 HGNC: 10751 AceView: SEPP1 Ensembl:ENSG00000250722 euGenes: HUgn6414
    ECgene: SEPP1 H-InvDB: SEPP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEPP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sepp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEPP1 gene:
    Search GeneIP for patents involving SEPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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