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Aliases for SEPHS2 Gene

Aliases for SEPHS2 Gene

  • Selenophosphate Synthetase 2 2 3
  • Selenophosphate Synthase 2 3 4
  • Selenium Donor Protein 2 3 4
  • EC 4 63
  • SPS2 3 4
  • SPS2b 3

External Ids for SEPHS2 Gene

Previous GeneCards Identifiers for SEPHS2 Gene

  • GC16M030491
  • GC16M030362
  • GC16M030454
  • GC16M028017
  • GC16M030448

Summaries for SEPHS2 Gene

Entrez Gene Summary for SEPHS2 Gene

  • This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. There is a pseudogene for this gene on chromosome 5. [provided by RefSeq, Aug 2013]

GeneCards Summary for SEPHS2 Gene

SEPHS2 (Selenophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include selenide, water dikinase activity. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot for SEPHS2 Gene

  • Synthesizes selenophosphate from selenide and ATP

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPHS2 Gene

Genomics for SEPHS2 Gene

Regulatory Elements for SEPHS2 Gene

Transcription factor binding sites by QIAGEN in the SEPHS2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEPHS2 Gene

30,443,625 bp from pter
30,446,181 bp from pter
2,557 bases
Minus strand

Genomic View for SEPHS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEPHS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPHS2 Gene

Proteins for SEPHS2 Gene

  • Protein details for SEPHS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenide, water dikinase 2
    Protein Accession:
    Secondary Accessions:
    • Q9BUQ2

    Protein attributes for SEPHS2 Gene

    448 amino acids
    Molecular mass:
    47305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEPHS2 Gene

Proteomics data for SEPHS2 Gene at MOPED

Post-translational modifications for SEPHS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEPHS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for SEPHS2 Gene

Suggested Antigen Peptide Sequences for SEPHS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
genes like me logo Genes that share domains with SEPHS2: view

No data available for Gene Families for SEPHS2 Gene

Function for SEPHS2 Gene

Molecular function for SEPHS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + selenide + H(2)O = AMP + selenophosphate + phosphate
UniProtKB/Swiss-Prot Function:
Synthesizes selenophosphate from selenide and ATP

Enzyme Numbers (IUBMB) for SEPHS2 Gene

Gene Ontology (GO) - Molecular Function for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004756 selenide, water dikinase activity NAS 8986768
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SEPHS2: view
genes like me logo Genes that share phenotypes with SEPHS2: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SEPHS2 Gene

Localization for SEPHS2 Gene

Subcellular locations from

Jensen Localization Image for SEPHS2 Gene COMPARTMENTS Subcellular localization image for SEPHS2 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEPHS2 Gene

Pathways & Interactions for SEPHS2 Gene

genes like me logo Genes that share pathways with SEPHS2: view

Pathways by source for SEPHS2 Gene

2 BioSystems pathways for SEPHS2 Gene
2 KEGG pathways for SEPHS2 Gene

Interacting Proteins for SEPHS2 Gene

Selected Interacting proteins: Q99611-SPS2_HUMAN for SEPHS2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process --
GO:0016260 selenocysteine biosynthetic process NAS 8986768
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for SIGNOR curated interactions for SEPHS2 Gene

Drugs & Compounds for SEPHS2 Gene

(5) Drugs for SEPHS2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 161
ATP Pharma Activator 0

(6) Additional Compounds for SEPHS2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenoxo-phosphino
Hydrogen selenide
  • Dihydrogen monoselenide
  • Dihydrogen selenide
  • Hydrogen selenide
  • Selane
  • Selenium dihydride
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
Phosphoroselenoic acid
  • Monoselenophosphoric acid
  • Selenophosphoric acid
  • SePO3
  • Trihydroxidoselenidophosphorus
  • [P(OH)3Se]
genes like me logo Genes that share compounds with SEPHS2: view

Transcripts for SEPHS2 Gene

mRNA/cDNA for SEPHS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEPHS2 Gene

Selenophosphate synthetase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEPHS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS2 Gene

No ASD Table

Relevant External Links for SEPHS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEPHS2 Gene

mRNA expression in normal human tissues for SEPHS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPHS2 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for SEPHS2 Gene

This gene is overexpressed in Skin (13.9), Salivary gland (9.7), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEPHS2 Gene

SOURCE GeneReport for Unigene cluster for SEPHS2 Gene Hs.118725

genes like me logo Genes that share expression patterns with SEPHS2: view

Protein tissue co-expression partners for SEPHS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SEPHS2 Gene

Orthologs for SEPHS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPHS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEPHS2 35
  • 88.89 (n)
  • 91.95 (a)
  • 83 (a)
(Canis familiaris)
Mammalia SEPHS2 35
  • 91.1 (n)
  • 94.8 (a)
(Mus musculus)
Mammalia Sephs2 35
  • 86.61 (n)
  • 90.64 (a)
Sephs2 16
Sephs2 36
  • 88 (a)
(Pan troglodytes)
Mammalia SEPHS2 35
  • 99.85 (n)
  • 99.78 (a)
(Rattus norvegicus)
Mammalia Sephs2 35
  • 86.58 (n)
  • 90.85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
-- 36
  • 86 (a)
-- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SEPHS2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SEPHS2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sephs2 35
  • 73.46 (n)
  • 83.03 (a)
Str.5825 35
(Danio rerio)
Actinopterygii sps2 35
  • 68.27 (n)
  • 75.48 (a)
sps2 36
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9452 35
fruit fly
(Drosophila melanogaster)
Insecta SelD 36
  • 65 (a)
Sps2 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea seld-1 36
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11091 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8569 36
  • 54 (a)
Species with no ortholog for SEPHS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPHS2 Gene

Gene Tree for SEPHS2 (if available)
Gene Tree for SEPHS2 (if available)

Paralogs for SEPHS2 Gene

Paralogs for SEPHS2 Gene

(1) SIMAP similar genes for SEPHS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEPHS2: view

Variants for SEPHS2 Gene

Sequence variations from dbSNP and Humsavar for SEPHS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1804600 - 30,444,923(+) TTCAG(A/C/G)ATTAT reference, missense
rs4787645 -- 30,446,029(+) CAGAA(C/T)GTCAC upstream-variant-2KB
rs4788418 -- 30,447,399(+) AAAAA(A/C)AAAAC upstream-variant-2KB
rs8063942 -- 30,444,113(+) TTCAT(C/G)TTACT utr-variant-3-prime
rs11337789 -- 30,447,403(+) AAAAA(-/A)CTGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEPHS2 Gene

Variant ID Type Subtype PubMed ID
nsv1783 CNV Loss 18451855

Variation tolerance for SEPHS2 Gene

Residual Variation Intolerance Score: 52.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPHS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPHS2 Gene

Disorders for SEPHS2 Gene

Relevant External Links for SEPHS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SEPHS2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPHS2 Gene

Publications for SEPHS2 Gene

  1. Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. (PMID: 19136613) Renko K. … Schomburg L. (FASEB J. 2009) 23 67
  2. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 23 67
  3. Biosynthesis of selenocysteine on its tRNA in eukaryotes. (PMID: 17194211) Xu X.M. … Hatfield D.L. (PLoS Biol. 2007) 23 67
  4. Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. (PMID: 17261084) Hu Y. … Becker K. (Biol. Chem. 2007) 23 67
  5. Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. (PMID: 17346238) Xu X.M. … Hatfield D.L. (Biochem. J. 2007) 23 67

Products for SEPHS2 Gene

Sources for SEPHS2 Gene

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