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Aliases for SEPHS2 Gene

Aliases for SEPHS2 Gene

  • Selenophosphate Synthetase 2 2 3 5
  • Selenophosphate Synthase 2 3 4
  • Selenium Donor Protein 2 3 4
  • EC 4 61
  • SPS2 3 4
  • Selenide, Water Dikinase 2 3
  • SPS2b 3

External Ids for SEPHS2 Gene

Previous GeneCards Identifiers for SEPHS2 Gene

  • GC16M030491
  • GC16M030362
  • GC16M030454
  • GC16M028017
  • GC16M030448
  • GC16M030449
  • GC16M030457
  • GC16M030458
  • GC16M030459

Summaries for SEPHS2 Gene

Entrez Gene Summary for SEPHS2 Gene

  • This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]

GeneCards Summary for SEPHS2 Gene

SEPHS2 (Selenophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenocompound metabolism. GO annotations related to this gene include selenide, water dikinase activity. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot for SEPHS2 Gene

  • Synthesizes selenophosphate from selenide and ATP.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPHS2 Gene

Genomics for SEPHS2 Gene

Regulatory Elements for SEPHS2 Gene

Enhancers for SEPHS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030538 1.5 Ensembl ENCODE dbSUPER 11.6 -95.2 -95221 5.3 PKNOX1 ATF1 MLX ARNT ARID4B DMAP1 ZNF48 TCF12 ZNF121 ZNF302 ZNF764 ZNF785 CD2BP2 ENSG00000235560 SMG1P2 ENSG00000260267 ENSG00000260304 ZNF688 ENSG00000239791 BCL7C
GH16G030547 1.5 Ensembl ENCODE dbSUPER 11.4 -102.8 -102792 2.4 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS JUNB NCOA1 ZNF689 ZNF764 ZNF688 ENSG00000239791 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2 ZNF768
GH16G030598 1.4 Ensembl ENCODE 11.5 -152.1 -152121 0.6 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 ZNF143 ENSG00000260267 ZNF764 ENSG00000260304 ENSG00000235560 PRR14 NPIPB13 ENSG00000239791 BCL7C ENSG00000261474 DCTPP1
GH16G030398 1.4 Ensembl ENCODE 10.6 +45.8 45786 3.8 FOXA2 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TBC1D10B SMG1P5 CD2BP2 SEPHS2 PIR39668 SEPT1 GC16P030401
GH16G030628 1.2 Ensembl ENCODE 11.3 -182.8 -182837 1.0 ARNT WRNIP1 ARID4B ZNF2 YY1 SLC30A9 ZNF766 ZNF143 REST PPARG CCDC189 PRR14 FBRS ZNF785 ENSG00000239791 ZNF688 SEPHS2 SRCAP SNORA30 PIR47019
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEPHS2 on UCSC Golden Path with GeneCards custom track

Promoters for SEPHS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the SEPHS2 gene promoter:

Genomic Location for SEPHS2 Gene

30,443,625 bp from pter
30,446,181 bp from pter
2,557 bases
Minus strand

Genomic View for SEPHS2 Gene

Genes around SEPHS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPHS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPHS2 Gene

Proteins for SEPHS2 Gene

  • Protein details for SEPHS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenide, water dikinase 2
    Protein Accession:
    Secondary Accessions:
    • Q9BUQ2

    Protein attributes for SEPHS2 Gene

    448 amino acids
    Molecular mass:
    47305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEPHS2 Gene

Selected DME Specific Peptides for SEPHS2 Gene


Post-translational modifications for SEPHS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEPHS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SEPHS2 Gene

Gene Families for SEPHS2 Gene

Suggested Antigen Peptide Sequences for SEPHS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
genes like me logo Genes that share domains with SEPHS2: view

Function for SEPHS2 Gene

Molecular function for SEPHS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + selenide + H(2)O = AMP + selenophosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Synthesizes selenophosphate from selenide and ATP.

Enzyme Numbers (IUBMB) for SEPHS2 Gene

Gene Ontology (GO) - Molecular Function for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004756 selenide, water dikinase activity TAS,NAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SEPHS2: view
genes like me logo Genes that share phenotypes with SEPHS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEPHS2 Gene

Localization for SEPHS2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEPHS2 gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEPHS2 Gene

Pathways & Interactions for SEPHS2 Gene

genes like me logo Genes that share pathways with SEPHS2: view

Pathways by source for SEPHS2 Gene

2 KEGG pathways for SEPHS2 Gene

Interacting Proteins for SEPHS2 Gene

Selected Interacting proteins: Q99611-SPS2_HUMAN for SEPHS2 Gene via IID

Gene Ontology (GO) - Biological Process for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IEA --
GO:0016259 selenocysteine metabolic process TAS --
GO:0016260 selenocysteine biosynthetic process NAS 8986768
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for SIGNOR curated interactions for SEPHS2 Gene

Drugs & Compounds for SEPHS2 Gene

(7) Drugs for SEPHS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 180
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for SEPHS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenoxo-phosphino
Hydrogen selenide
  • Dihydrogen monoselenide
  • Dihydrogen selenide
  • Hydrogen selenide
  • Selane
  • Selenium dihydride
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
Phosphoroselenoic acid
  • Monoselenophosphoric acid
  • Selenophosphoric acid
  • SePO3
  • Trihydroxidoselenidophosphorus
  • [P(OH)3Se]
genes like me logo Genes that share compounds with SEPHS2: view

Transcripts for SEPHS2 Gene

mRNA/cDNA for SEPHS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEPHS2 Gene

Selenophosphate synthetase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS2 Gene

No ASD Table

Relevant External Links for SEPHS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEPHS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEPHS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPHS2 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for SEPHS2 Gene

This gene is overexpressed in Skin (13.9), Salivary gland (9.7), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEPHS2 Gene

Protein tissue co-expression partners for SEPHS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEPHS2 Gene:


SOURCE GeneReport for Unigene cluster for SEPHS2 Gene:


Evidence on tissue expression from TISSUES for SEPHS2 Gene

  • Liver(4.8)
  • Nervous system(4.6)
  • Muscle(4.4)
  • Skin(4.3)
  • Kidney(3.7)
  • Intestine(3.1)
  • Blood(2.7)
  • Lung(2.5)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SEPHS2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEPHS2 Gene

Orthologs for SEPHS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPHS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEPHS2 34
  • 99.85 (n)
(Canis familiaris)
Mammalia SEPHS2 34
  • 91.1 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
-- 35
  • 89 (a)
-- 35
  • 86 (a)
(Bos Taurus)
Mammalia SEPHS2 34 35
  • 88.89 (n)
(Mus musculus)
Mammalia Sephs2 34 16 35
  • 86.61 (n)
(Rattus norvegicus)
Mammalia Sephs2 34
  • 86.58 (n)
(Ornithorhynchus anatinus)
Mammalia SEPHS2 35
  • 85 (a)
(Anolis carolinensis)
Reptilia SEPHS2 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sephs2 34
  • 73.46 (n)
Str.5825 34
(Danio rerio)
Actinopterygii sps2 35 34
  • 68.27 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9452 34
fruit fly
(Drosophila melanogaster)
Insecta SelD 35
  • 65 (a)
Sps2 35
  • 45 (a)
(Caenorhabditis elegans)
Secernentea seld-1 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8569 35
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11091 34
Species where no ortholog for SEPHS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPHS2 Gene

Gene Tree for SEPHS2 (if available)
Gene Tree for SEPHS2 (if available)

Paralogs for SEPHS2 Gene

Paralogs for SEPHS2 Gene

(1) SIMAP similar genes for SEPHS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEPHS2: view

Variants for SEPHS2 Gene

Sequence variations from dbSNP and Humsavar for SEPHS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000619174 -- 30,443,678(+) TACTC(C/T)TTATT utr-variant-3-prime
rs1000736086 -- 30,446,886(+) GCCTC(C/G)GCCTC upstream-variant-2KB
rs1001377947 -- 30,447,062(+) GTACG(C/T)GGTAC upstream-variant-2KB
rs1001913764 -- 30,444,161(+) TACCC(A/C)AGTGA utr-variant-3-prime
rs1001986190 -- 30,447,679(+) TTTGC(A/G)AAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEPHS2 Gene

Variant ID Type Subtype PubMed ID
nsv1783 CNV deletion 18451855

Variation tolerance for SEPHS2 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPHS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPHS2 Gene

Disorders for SEPHS2 Gene

Relevant External Links for SEPHS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEPHS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPHS2 Gene

Publications for SEPHS2 Gene

  1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PMID: 8986768) Guimaraes M.J. … Zlotnik A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  2. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. (PMID: 17916946) Xu X.M. … Hatfield D.L. (Biol Trace Elem Res 2007) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PMID: 15534230) Tamura T. … Inagaki K. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 22 64
  5. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PMID: 10608886) Lescure A. … Krol A. (J. Biol. Chem. 1999) 2 3 64

Products for SEPHS2 Gene

Sources for SEPHS2 Gene

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