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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPHS2 Gene

protein-coding   GIFtS: 55
GCID: GC16M030454

Selenophosphate Synthetase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selenophosphate Synthetase 21 2     EC 2.7.9.33 8
SPS22 3 5     SPS2b2
Selenium Donor Protein 22 3     Selenide, Water Dikinase 22
Selenophosphate Synthase 22 3     

External Ids:    HGNC: 196861   Entrez Gene: 229282   Ensembl: ENSG000001799187   OMIM: 6062185   UniProtKB: Q996113   

Export aliases for SEPHS2 gene to outside databases

Previous GC identifers: GC16M030491 GC16M030362 GC16M028017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPHS2 Gene:
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the
selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at
in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called
a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine
residue in its predicted active site. There is a pseudogene for this gene on chromosome 5. (provided by RefSeq,
Aug 2013)

GeneCards Summary for SEPHS2 Gene: 
SEPHS2 (selenophosphate synthetase 2) is a protein-coding gene. Diseases associated with SEPHS2 include non-small cell lung carcinoma, and lung adenocarcinoma, and among its related super-pathways are Metabolism. GO annotations related to this gene include selenide, water dikinase activity and ATP binding. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
Function: Synthesizes selenophosphate from selenide and ATP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPHS2 gene promoter:
         c-Fos   AML1a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEPHS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEPHS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPHS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPHS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030454:  view genomic region     (about GC identifiers)

Start:
30,454,952 bp from pter      End:
30,457,502 bp from pter
Size:
2,551 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611 (See protein sequence)
Recommended Name: Selenide, water dikinase 2  
Size: 448 amino acids; 47305 Da
Secondary accessions: Q9BUQ2

Explore the universe of human proteins at neXtProt for SEPHS2: NX_Q99611

Explore proteomics data for SEPHS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99611

  • 4/13 DME Specific Peptides for SEPHS2 (Q99611) (see all 13)
     TDITGFG  VTGGQTV  TSGGLLI  NAHAATD 

    SEPHS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEPHS2 Protein Expression
    REFSEQ proteins: NP_036380.2  
    ENSEMBL proteins: 
     ENSP00000418669   ENSP00000443601   ENSP00000426234  

    Human Recombinant Protein Products for SEPHS2: 
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    Novus Biologicals SEPHS2 Proteins
    Novus Biologicals SEPHS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEPHS2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    SEPHS2 for ontologies           About GeneDecksing



    SEPHS2 Antibody Products: 
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    Assay Products for SEPHS2: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEPHS2 
    Cloud-Clone Corp. CLIAs for SEPHS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016188 PurM_N-like
     IPR000728 AIR_synth_N_dom
     IPR010918 AIR_synth_C_dom
     IPR004536 SelD

    Graphical View of Domain Structure for InterPro Entry Q99611

    ProtoNet protein and cluster: Q99611

    2 Blocks protein domains:
    IPB000728 AIR synthase related protein
    IPB010918 AIR synthase related protein


    UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
    Similarity: Belongs to the selenophosphate synthase 1 family. Class I subfamily


    SEPHS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPS2_HUMAN, Q99611
    Function: Synthesizes selenophosphate from selenide and ATP
    Catalytic activity: ATP + selenide + H(2)O = AMP + selenophosphate + phosphate

         Enzyme Number (IUBMB): EC 2.7.9.31 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004756selenide, water dikinase activity NAS8986768
    GO:0005524ATP binding IEA--
         
    SEPHS2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SEPHS2:
     G0/1 arrest  Increased G1 DNA content  Increased telomerase activity 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEPHS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEPHS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEPHS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEPHS2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPHS2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSEPHS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPHS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPHS2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SEPHS2

    Clone
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    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPHS2
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                         Customized lentivirus expression plasmids for stable overexpression of SEPHS2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEPHS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Selenium Pathway
    Selenium Pathway
    3Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    4Selenocompound metabolism
    Selenocompound metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SEPHS2
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


    2         Kegg Pathways  (Kegg details for SEPHS2):
        Selenocompound metabolism
    Metabolic pathways


    SEPHS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPHS2

    1 Interacting protein for SEPHS2 (Q996113) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016260selenocysteine biosynthetic process NAS8986768

    SEPHS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPHS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEPHS2 (SPS2)

    9 HMDB Compounds for SEPHS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoroselenoic acidMonoselenophosphoric acid (see all 5)25758-66-1--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--
    SelenophosphatePhosphorus selenide (PSe) (see all 4)289702-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for SEPHS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenophosphate 97.6 16 15534230 (1), 16508009 (1), 18790070 (1), 17346238 (1) (see all 8)
    selenocysteine 89.7 3 15534230 (2), 8986768 (1)
    selenium 73.2 6 15534230 (1), 17916946 (1), 19136613 (1)
    atp 26.8 1 17916946 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPHS2 / SPS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEPHS2 gene: 
    NM_012248.3  

    Unigene Cluster for SEPHS2:

    Selenophosphate synthetase 2
    Hs.118725  [show with all ESTs]
    Unigene Representative Sequence: NM_012248
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478753(uc021tgl.1 uc021tgl.1) ENST00000478753(uc021tgl.1 uc021tgl.1)
    ENST00000542752(uc002dyh.1) ENST00000500504
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPHS2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSEPHS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEPHS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPHS2
    Clone
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    OriGene clones in human, mouse for SEPHS2 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPHS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPHS2
    Sirion Biotech Customized lentivirus for stable overexpression of SEPHS2 
                         Customized lentivirus expression plasmids for stable overexpression of SEPHS2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEPHS2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPHS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPHS2

    Additional mRNA sequence: 

    AK092003.1 AK093889.1 AK303275.1 BC002381.2 BC016643.1 U43286.1 

    11 DOTS entries:

    DT.218746  DT.95239105  DT.100825505  DT.91758013  DT.100638562  DT.100680963  DT.95363464  DT.100798908 
    DT.95363484  DT.100825508  DT.95363485 

    24/338 AceView cDNA sequences (see all 338):

    AA595179 AA708868 BM825265 BM683218 Z41023 CA314976 AI963446 BU740530 
    BF109804 BU619153 CB216511 AV719555 AU130256 BI334930 AX748354 AI015544 
    AV650872 AU280637 BI915786 AK093889 AW510362 BI916574 AW148661 AA725394 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPHS2 expression in normal human tissues (normalized intensities)      SEPHS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCCACAGA
    SEPHS2 Expression
    About this image


    SEPHS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Telencephalon

    See SEPHS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPHS2

    SOURCE GeneReport for Unigene cluster: Hs.118725
        SABiosciences Custom PCR Arrays for SEPHS2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPHS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SEPHS2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sephs21 , 5 selenophosphate synthetase 21, 5 86.38(n)1
    90.4(a)1
      7 (69.43 cM)5
    207681  NM_009266.31  NP_033292.21 
     1272725615 
    lizard
    (Anolis carolinensis)
    Reptilia SEPHS26
    selenophosphate synthetase 2
    87(a)
    1 ↔ 1
    2(89776488-89783094)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58252 Transcribed sequence with moderate similarity to protein more 76.14(n)    CF152055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sps21 selenophosphate synthetase 2 67.53(n)
    74.59(a)
      352933  NM_001004295.2  NP_001004295.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SelD6
    Sps26
    Selenophosphate synthetase 2
    64(a)
    43(a)
    many ↔ many
    many ↔ many
    2R(10156275-10158159)
    2L(10342594-10344223)
    worm
    (Caenorhabditis elegans)
    Secernentea seld-11 Protein SELD-1 52.92(n)
    50.97(a)
      189912  NM_070203.1  NP_502604.1 


    ENSEMBL Gene Tree for SEPHS2 (if available)
    TreeFam Gene Tree for SEPHS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEPHS2 gene
    SEPHS12  
    1 SIMAP similar gene for SEPHS2 using alignment to 4 protein entries:     SPS2_HUMAN (see all proteins):
    SEPHS1

    SEPHS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in SEPHS2 are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467679421,2
    --30454501(+) CCTGCA/GTAGGT 1 -- ds50010--------
    rs1869388721,2
    --30454515(+) AGGCAA/GTCACC 1 -- ds50010--------
    rs1915283401,2
    --30454524(+) CCTGGC/TTGTGT 1 -- ds50010--------
    rs1489016841,2
    --30454758(+) AACCCA/TTGGGG 1 -- ds50010--------
    rs1124774881,2
    F--30454764(+) TGGGGC/TGTATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1435647921,2
    --30454854(+) CATCAC/GGGAAA 1 -- ds50010--------
    rs1509794511,2
    C--30454877(+) TGCTAC/TACCAG 1 -- ds50010--------
    rs1148883631,2
    F--30454904(+) GGTTCG/ATTTTA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1408111031,2
    C--30455064(+) GGCCTC/GGGCTC 1 -- ut310--------
    rs1887453841,2
    --30455269(+) CTCTTA/CACAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEPHS2 (30454952 - 30457502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEPHS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1783CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPHS2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606218    OMIM disorders: --

    4 diseases for SEPHS2:    About MalaCards
    non-small cell lung carcinoma    lung adenocarcinoma    adenocarcinoma    hepatitis


    SEPHS2 for disorders           About GeneDecksing


    Export disorders for SEPHS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPHS2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SEPHS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PubMed id 8986768)1, 2, 9 Guimaraes M.J....Zlotnik A. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PubMed id 10608886)1, 3 Lescure A.... Krol A. (1999)
    4. A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies. (PubMed id 7588067)1, 2 Guimaraes M.J.... McClanahan T. (1995)
    5. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PubMed id 15534230)1, 9 Tamura T....Inagaki K. (2004)
    6. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. (PubMed id 17916946)1, 9 Xu X.M....Hatfield D.L. (2007)
    7. Selenium alters miRNA profile in an intestinal cell li ne: Evidence that miR-185 regulates expression of GPX2 and SEPSH2. (PubMed id 23934683)1 Maciel-Dominguez A....Hesketh J. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22928 HGNC: 19686 AceView: SEPHS2 Ensembl:ENSG00000179918 euGenes: HUgn22928
    ECgene: SEPHS2 Kegg: 22928 H-InvDB: SEPHS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPHS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEPHS2 gene:
    Search GeneIP for patents involving SEPHS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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