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Aliases for SEPHS2 Gene

Aliases for SEPHS2 Gene

  • Selenophosphate Synthetase 2 2 3 5
  • Selenophosphate Synthase 2 3 4
  • Selenium Donor Protein 2 3 4
  • EC 4 56
  • SPS2 3 4
  • Selenide, Water Dikinase 2 3

External Ids for SEPHS2 Gene

Previous GeneCards Identifiers for SEPHS2 Gene

  • GC16M030491
  • GC16M030362
  • GC16M030454
  • GC16M028017
  • GC16M030448
  • GC16M030449
  • GC16M030457
  • GC16M030458
  • GC16M030459
  • GC16M030460
  • GC16M030461

Summaries for SEPHS2 Gene

Entrez Gene Summary for SEPHS2 Gene

  • This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]

GeneCards Summary for SEPHS2 Gene

SEPHS2 (Selenophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Metabolism. Gene Ontology (GO) annotations related to this gene include selenide, water dikinase activity. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot for SEPHS2 Gene

  • Synthesizes selenophosphate from selenide and ATP.

Additional gene information for SEPHS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPHS2 Gene

Genomics for SEPHS2 Gene

GeneHancer (GH) Regulatory Elements for SEPHS2 Gene

Promoters and enhancers for SEPHS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I030444 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 555.8 -0.2 -241 4.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D SSRP1 SEPHS2 ZNF689 ZNF646 SETD1A ENSG00000260304 FBRS MIR762HG INO80E ZNF688 ZNF764
GH16I030393 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +51.1 51055 2.9 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 SEPT1 ZNF48 SETD1A FUS INO80E SRCAP ZNF785 ZNF764 ZNF689 SMG1P5
GH16I030538 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.7 -95.2 -95221 5.3 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF48 TCF12 ZNF121 ZNF213 ZNF764 ZNF785 INO80E ENSG00000235560 SRCAP SMG1P2 ENSG00000260267 SMG1P5 ENSG00000260304 ENSG00000260114
GH16I030598 Enhancer 1.3 Ensembl ENCODE 11.5 -152.1 -152120 0.6 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF213 ZNF302 INO80E SRCAP FBRS ZNF764 ENSG00000260267 SETD1A PRR14 RNF40 SMG1P5 ENSG00000235560
GH16I030547 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 -102.8 -102792 2.4 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS ATF7 NCOA1 ZNF689 ZNF764 SETD1A ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SEPHS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEPHS2 gene promoter:

Genomic Locations for SEPHS2 Gene

Genomic Locations for SEPHS2 Gene
2,557 bases
Minus strand

Genomic View for SEPHS2 Gene

Genes around SEPHS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPHS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPHS2 Gene

Proteins for SEPHS2 Gene

  • Protein details for SEPHS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenide, water dikinase 2
    Protein Accession:
    Secondary Accessions:
    • Q9BUQ2

    Protein attributes for SEPHS2 Gene

    448 amino acids
    Molecular mass:
    47305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEPHS2 Gene

Selected DME Specific Peptides for SEPHS2 Gene


Post-translational modifications for SEPHS2 Gene

No Post-translational modifications

Other Protein References for SEPHS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SEPHS2 Gene

Gene Families for SEPHS2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SEPHS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
  • Belongs to the selenophosphate synthase 1 family. Class I subfamily.
genes like me logo Genes that share domains with SEPHS2: view

Function for SEPHS2 Gene

Molecular function for SEPHS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + selenide + H(2)O = AMP + selenophosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Synthesizes selenophosphate from selenide and ATP.

Enzyme Numbers (IUBMB) for SEPHS2 Gene

Phenotypes From GWAS Catalog for SEPHS2 Gene

Gene Ontology (GO) - Molecular Function for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004756 selenide, water dikinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SEPHS2: view
genes like me logo Genes that share phenotypes with SEPHS2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEPHS2 Gene

Localization for SEPHS2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEPHS2 gene
Compartment Confidence
cytosol 5
nucleus 3
peroxisome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SEPHS2 Gene

Pathways & Interactions for SEPHS2 Gene

genes like me logo Genes that share pathways with SEPHS2: view

Pathways by source for SEPHS2 Gene

2 KEGG pathways for SEPHS2 Gene

Interacting Proteins for SEPHS2 Gene

Gene Ontology (GO) - Biological Process for SEPHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IEA --
GO:0016259 selenocysteine metabolic process TAS --
GO:0016260 selenocysteine biosynthetic process NAS 8986768
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SEPHS2: view

No data available for SIGNOR curated interactions for SEPHS2 Gene

Drugs & Compounds for SEPHS2 Gene

(6) Drugs for SEPHS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Investigational, Vet_approved Pharma 193
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Selenocysteine Experimental Pharma 0

(4) Additional Compounds for SEPHS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenoxo-phosphino
Hydrogen selenide
  • Dihydrogen monoselenide
  • Dihydrogen selenide
  • Hydrogen selenide
  • Selane
  • Selenium dihydride
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
Phosphoroselenoic acid
  • Monoselenophosphoric acid
  • Selenophosphoric acid
  • SePO3
  • Trihydroxidoselenidophosphorus
  • [P(OH)3Se]
genes like me logo Genes that share compounds with SEPHS2: view

Transcripts for SEPHS2 Gene

mRNA/cDNA for SEPHS2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEPHS2 Gene

Selenophosphate synthetase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS2 Gene

No ASD Table

Relevant External Links for SEPHS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEPHS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEPHS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEPHS2 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for SEPHS2 Gene

This gene is overexpressed in Skin (13.9), Salivary gland (9.7), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SEPHS2 Gene

Protein tissue co-expression partners for SEPHS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEPHS2 Gene:


SOURCE GeneReport for Unigene cluster for SEPHS2 Gene:


Evidence on tissue expression from TISSUES for SEPHS2 Gene

  • Liver(4.8)
  • Nervous system(4.6)
  • Muscle(4.4)
  • Skin(4.3)
  • Kidney(3.7)
  • Intestine(3.1)
  • Blood(2.7)
  • Lung(2.5)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SEPHS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEPHS2 Gene

Orthologs for SEPHS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPHS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEPHS2 33
  • 99.85 (n)
(Canis familiaris)
Mammalia SEPHS2 33
  • 91.1 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
-- 34
  • 89 (a)
-- 34
  • 86 (a)
(Bos Taurus)
Mammalia SEPHS2 33 34
  • 88.89 (n)
(Mus musculus)
Mammalia Sephs2 33 16 34
  • 86.61 (n)
(Rattus norvegicus)
Mammalia Sephs2 33
  • 86.58 (n)
(Ornithorhynchus anatinus)
Mammalia SEPHS2 34
  • 85 (a)
(Anolis carolinensis)
Reptilia SEPHS2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sephs2 33
  • 73.46 (n)
Str.5825 33
(Danio rerio)
Actinopterygii sps2 34 33
  • 68.27 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9452 33
fruit fly
(Drosophila melanogaster)
Insecta SelD 34
  • 65 (a)
Sps2 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea seld-1 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8569 34
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11091 33
Species where no ortholog for SEPHS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPHS2 Gene

Gene Tree for SEPHS2 (if available)
Gene Tree for SEPHS2 (if available)

Paralogs for SEPHS2 Gene

Paralogs for SEPHS2 Gene

(1) SIMAP similar genes for SEPHS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEPHS2: view

Variants for SEPHS2 Gene

Sequence variations from dbSNP and Humsavar for SEPHS2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000619174 -- 30,443,678(-) T/C 3_prime_UTR_variant
rs1000736086 -- 30,446,886(-) G/A/C/T upstream_transcript_variant
rs1001377947 -- 30,447,062(-) T/C upstream_transcript_variant
rs1001913764 -- 30,444,161(-) A/C 3_prime_UTR_variant
rs1001986190 -- 30,447,679(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SEPHS2 Gene

Variant ID Type Subtype PubMed ID
nsv1783 CNV deletion 18451855

Variation tolerance for SEPHS2 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEPHS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPHS2 Gene

Disorders for SEPHS2 Gene

Additional Disease Information for SEPHS2

No disorders were found for SEPHS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPHS2 Gene

Publications for SEPHS2 Gene

  1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PMID: 8986768) Guimarães MJ … Zlotnik A (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 22 58
  2. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. (PMID: 17916946) Xu XM … Hatfield DL (Biological trace element research 2007) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PMID: 15534230) Tamura T … Inagaki K (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 22 58
  5. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PMID: 10608886) Lescure A … Krol A (The Journal of biological chemistry 1999) 2 3 58

Products for SEPHS2 Gene

Sources for SEPHS2 Gene

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