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SEPHS2 Gene

protein-coding   GIFtS: 55
GCID: GC16M030454

Selenophosphate Synthetase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenophosphate Synthetase 21 2     EC 2.7.9.33 8
SPS22 3 5     SPS2b2
Selenium Donor Protein 22 3     Selenide, Water Dikinase 22
Selenophosphate Synthase 22 3     

External Ids:    HGNC: 196861   Entrez Gene: 229282   Ensembl: ENSG000001799187   OMIM: 6062185   UniProtKB: Q996113   

Export aliases for SEPHS2 gene to outside databases

Previous GC identifers: GC16M030491 GC16M030362 GC16M028017


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPHS2 Gene:
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the
selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at
in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called
a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine
residue in its predicted active site. There is a pseudogene for this gene on chromosome 5. (provided by RefSeq,
Aug 2013)

GeneCards Summary for SEPHS2 Gene:
SEPHS2 (selenophosphate synthetase 2) is a protein-coding gene. GO annotations related to this gene include selenide, water dikinase activity. An important paralog of this gene is SEPHS1.

UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
Function: Synthesizes selenophosphate from selenide and ATP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPHS2 gene promoter:
         c-Fos   AML1a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEPHS2 promoter sequence
   Search Chromatin IP Primers for SEPHS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPHS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPHS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030454:  view genomic region     (about GC identifiers)

Start:
30,454,952 bp from pter      End:
30,457,502 bp from pter
Size:
2,551 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611 (See protein sequence)
Recommended Name: Selenide, water dikinase 2  
Size: 448 amino acids; 47305 Da
Secondary accessions: Q9BUQ2

Explore the universe of human proteins at neXtProt for SEPHS2: NX_Q99611

Explore proteomics data for SEPHS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SEPHS2 (Q99611) (see all 13)
     TDITGFG  VTGGQTV  TSGGLLI  NAHAATD 


    See SEPHS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036380.2  
    ENSEMBL proteins: 
     ENSP00000418669   ENSP00000443601   ENSP00000426234  

    SEPHS2 Human Recombinant Protein Products:

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    Novus Biologicals SEPHS2 Proteins
    Novus Biologicals SEPHS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEPHS2

     
    Search eBioscience for Proteins for SEPHS2 

     
    antibodies-online proteins for SEPHS2 (7 products) 

     
    Search antibodies-online for peptides for SEPHS2

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    antibodies-online antibodies for SEPHS2 (21 products) 

    SEPHS2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SEPHS2
    Cloud-Clone Corp. CLIAs for SEPHS2
    Search eBioscience for ELISAs for SEPHS2 
    antibodies-online kits for SEPHS2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016188 PurM_N-like
     IPR000728 AIR_synth_N_dom
     IPR010918 AIR_synth_C_dom
     IPR004536 SelD

    Graphical View of Domain Structure for InterPro Entry Q99611

    ProtoNet protein and cluster: Q99611

    2 Blocks protein domains:
    IPB000728 AIR synthase related protein
    IPB010918 AIR synthase related protein


    UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
    Similarity: Belongs to the selenophosphate synthase 1 family. Class I subfamily


    Find genes that share domains with SEPHS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPS2_HUMAN, Q99611
    Function: Synthesizes selenophosphate from selenide and ATP
    Catalytic activity: ATP + selenide + H(2)O = AMP + selenophosphate + phosphate

         Enzyme Number (IUBMB): EC 2.7.9.31 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004756selenide, water dikinase activity NAS8986768
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SEPHS2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SEPHS2:
     G0/1 arrest  Increased G1 DNA content  Increased telomerase activity 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEPHS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEPHS2:
    hsa-mir-484 (MIRT041739), hsa-mir-1301-3p (MIRT036036), hsa-mir-193b-3p (MIRT041273), hsa-mir-615-3p (MIRT039955)

    Block miRNA regulation of human, mouse, rat SEPHS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSEPHS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEPHS2
    Predesigned siRNA for gene silencing in human, mouse, rat SEPHS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEPHS2

    Clone
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    OriGene clones in human, mouse for SEPHS2 (see all 7)
    OriGene ORF clones in mouse, rat for SEPHS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
    Sino Biological Human cDNA Clone for SEPHS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPHS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPHS2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SEPHS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEPHS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with SEPHS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPHS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Selenocompound metabolism
    Selenocompound metabolism
    3Selenium Pathway
    Selenium Pathway
    4Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    Find genes that share SuperPaths with SEPHS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SEPHS2
        Selenium Metabolism and Selenoproteins
    Selenium Pathway



    2 Kegg Pathways  (Kegg details for SEPHS2):
        Selenocompound metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEPHS2
    Interactions:

        Search GeneGlobe Interaction Network for SEPHS2

    1 Interacting protein for SEPHS2 (Q996113) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016260selenocysteine biosynthetic process NAS8986768

    Find genes that share ontologies with SEPHS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEPHS2 (SPS2)

    9 HMDB Compounds for SEPHS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoroselenoic acidMonoselenophosphoric acid (see all 5)25758-66-1--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--
    SelenophosphatePhosphorus selenide (PSe) (see all 4)289702-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for SEPHS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenophosphate 97.6 16 15534230 (1), 16508009 (1), 18790070 (1), 17346238 (1) (see all 8)
    selenocysteine 89.7 3 15534230 (2), 8986768 (1)
    selenium 73.2 6 15534230 (1), 17916946 (1), 19136613 (1)
    atp 26.8 1 17916946 (1)



    Find genes that share compounds with SEPHS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEPHS2 gene: 
    NM_012248.3  

    Unigene Cluster for SEPHS2:

    Selenophosphate synthetase 2
    Hs.118725  [show with all ESTs]
    Unigene Representative Sequence: NM_012248
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478753(uc021tgl.1 uc021tgl.1) ENST00000478753(uc021tgl.1 uc021tgl.1)
    ENST00000542752(uc002dyh.1) ENST00000500504
    miRNA
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    Block miRNA regulation of human, mouse, rat SEPHS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSEPHS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SEPHS2
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    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPHS2
    Primer
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    OriGene qPCR primer pairs and template standards for SEPHS2
    OriGene qSTAR qPCR primer pairs in human, mouse for SEPHS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEPHS2
      QuantiTect SYBR Green Assays in human, mouse, rat SEPHS2
      QuantiFast Probe-based Assays in human, mouse, rat SEPHS2

    Additional mRNA sequence: 

    AK092003.1 AK093889.1 AK303275.1 BC002381.2 BC016643.1 U43286.1 

    11 DOTS entries:

    DT.218746  DT.95239105  DT.100825505  DT.91758013  DT.100638562  DT.100680963  DT.95363464  DT.100798908 
    DT.95363484  DT.100825508  DT.95363485 

    Selected AceView cDNA sequences (see all 338):

    W69359 BE857744 AA595179 AA564319 BI915786 AL531235 AI399654 CD364350 
    AI360734 BC002381 AL551460 BM722868 BX425316 CA426063 Z41023 AA767944 
    AI963446 BM825265 CN484377 BI916574 CA449998 BM923693 BU859641 AA709310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPHS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCCACAGA
    SEPHS2 Expression
    About this image


    SEPHS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    SEPHS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPHS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118725
        Custom PCR Arrays for SEPHS2
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SEPHS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sephs21 , 5 selenophosphate synthetase 21, 5 86.61(n)1
    90.64(a)1
      7 (69.43 cM)5
    207681  NM_009266.31  NP_033292.21 
     1272725615 
    lizard
    (Anolis carolinensis)
    Reptilia SEPHS26
    selenophosphate synthetase 2
    86(a)
    1 ↔ 1
    2(89776488-89783094)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58252 Transcribed sequence with moderate similarity to protein more 76.14(n)    CF152055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sps21 selenophosphate synthetase 2 68.27(n)
    75.48(a)
      352933  NM_001004295.2  NP_001004295.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SelD6
    Sps26
    Selenophosphate synthetase 2
    65(a)
    45(a)
    many ↔ many
    many ↔ many
    2R(10156275-10158159)
    2L(10342594-10344223)
    worm
    (Caenorhabditis elegans)
    Secernentea seld-16
    Protein SELD-1 (seld-1) mRNA, complete cds
    47(a)
    1 → many
    IV(13506079-13509215) WBGene00012867


    ENSEMBL Gene Tree for SEPHS2 (if available)
    TreeFam Gene Tree for SEPHS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPHS2 gene
    SEPHS12  
    1 SIMAP similar gene for SEPHS2 using alignment to 4 protein entries:     SPS2_HUMAN (see all proteins):
    SEPHS1

    Find genes that share paralogs with SEPHS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEPHS2 (see all 98)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467679421,2
    --30454501(+) CCTGCA/GTAGGT 1 -- ds50010--------
    rs1869388721,2
    --30454515(+) AGGCAA/GTCACC 1 -- ds50010--------
    rs1915283401,2
    --30454524(+) CCTGGC/TTGTGT 1 -- ds50010--------
    rs1489016841,2
    --30454758(+) AACCCA/TTGGGG 1 -- ds50010--------
    rs1124774881,2
    F--30454764(+) TGGGGC/TGTATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1435647921,2
    --30454854(+) CATCAC/GGGAAA 1 -- ds50010--------
    rs1509794511,2
    C--30454877(+) TGCTAC/TACCAG 1 -- ds50010--------
    rs1148883631,2
    F--30454904(+) GGTTCG/ATTTTA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1408111031,2
    C--30455064(+) GGCCTC/GGGCTC 1 -- ut310--------
    rs1887453841,2
    --30455269(+) CTCTTA/CACAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEPHS2 (30454952 - 30457502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEPHS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1783CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPHS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPHS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606218    OMIM disorders: --


    Find genes that share disorders with SEPHS2           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPHS2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SEPHS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PubMed id 8986768)1, 2, 9 Guimaraes M.J....Zlotnik A. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PubMed id 10608886)1, 3 Lescure A.... Krol A. (J. Biol. Chem. 1999)
    4. A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies. (PubMed id 7588067)1, 2 Guimaraes M.J.... McClanahan T. (Development 1995)
    5. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PubMed id 15534230)1, 9 Tamura T....Inagaki K. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. (PubMed id 17916946)1, 9 Xu X.M....Hatfield D.L. (Biol Trace Elem Res 2007)
    7. Selenium alters miRNA profile in an intestinal cell line: Evidence that miR-185 regulates expression of GPX2 and SEPSH2. (PubMed id 23934683)1 Maciel-Dominguez A....Hesketh J. (amp 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22928 HGNC: 19686 AceView: SEPHS2 Ensembl:ENSG00000179918 euGenes: HUgn22928
    ECgene: SEPHS2 Kegg: 22928 H-InvDB: SEPHS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEPHS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEPHS2 gene:
    Search GeneIP for patents involving SEPHS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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