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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEPHS2 Gene

protein-coding   GIFtS: 54
GCID: GC16M030454

selenophosphate synthetase 2
 Explore 7 diseases affiliated with
SEPHS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SEPHS2    

Aliases
for SEPHS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Selenophosphate Synthetase 21 2     Selenophosphate Synthase 22 3
SPS21 2 3 5     EC 2.7.9.33 8
SPS2b1 2     Selenide, Water Dikinase 22
Selenium Donor Protein 22 3     

External Ids:    HGNC: 196861   Entrez Gene: 229282   Ensembl: ENSG000001799187   OMIM: 6062185   UniProtKB: Q996113   

Export aliases for SEPHS2 gene to outside databases

Previous GC identifers: GC16M030491 GC16M030362 GC16M028017


Summaries
for SEPHS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEPHS2:
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium
donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA
codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3' UTR of the gene has
a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct
the incorporation of selenocysteine rather than signal a translational stop. Alternatively spliced transcripts have
been identified, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
Function: Synthesizes selenophosphate from selenide and ATP




Genomic Views
for SEPHS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEPHS2 gene promoter:
         c-Fos   AML1a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEPHS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEPHS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEPHS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SEPHS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPHS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030454:  view genomic region     (about GC identifiers)

Start:
 30,454,952 bp from pter      End:
 30,457,502 bp from pter
Size:
 2,551 bases      Orientation:
 minus strand

Proteins
for SEPHS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611 (See protein sequence)
Recommended Name: Selenide, water dikinase 2  
Size: 448 amino acids; 47305 Da
Secondary accessions: Q9BUQ2

Explore the universe of human proteins at neXtProt for SEPHS2: NX_Q99611

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99611

    • 4/13 DME Specific Peptides for SEPHS2 (Q99611) (see all 13)
     TDITGFG  VTGGQTV  TSGGLLI  NAHAATD 

    SEPHS2 Protein expression data from MOPED and PaxDb:    About this image 
    SEPHS2 Protein Expression
    REFSEQ proteins: NP_036380.2  
    ENSEMBL proteins: 
     ENSP00000418669   ENSP00000443601   ENSP00000426234  

    Human Recombinant Protein Products for SEPHS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: SEPHS2
    OriGene Custom Protein Services for SEPHS2 
    GenScript Custom Purified and Recombinant Proteins Services for SEPHS2
    Novus Biologicals SEPHS2 Proteins
    Novus Biologicals SEPHS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEPHS2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    SEPHS2 for ontologies           About GeneDecksing



    SEPHS2 Antibody Products: 
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    Uscn ELISAs and CLIAs for SEPHS2

    Protein Domains /
    Families
    for SEPHS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEPHS2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016188 PurM_N-like
     IPR000728 AIR_synth_N_dom
     IPR010918 AIR_synth_C_dom
     IPR004536 SelD

    Graphical View of Domain Structure for InterPro Entry Q99611

    ProtoNet protein and cluster: Q99611

    2 Blocks protein families:
    IPB000728 AIR synthase related protein
    IPB010918 AIR synthase related protein


    UniProtKB/Swiss-Prot: SPS2_HUMAN, Q99611
    Similarity: Belongs to the selenophosphate synthase 1 family. Class I subfamily


    Function
    for SEPHS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPS2_HUMAN, Q99611
    Function: Synthesizes selenophosphate from selenide and ATP
    Catalytic activity: ATP + selenide + H(2)O = AMP + selenophosphate + phosphate

         Enzyme Number (IUBMB): EC 2.7.9.31 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004756selenide, water dikinase activity NAS8986768
    GO:0005524ATP binding IEA--
         
    SEPHS2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SEPHS2:
     G0/1 arrest  Increased G1 DNA content  Increased telomerase activity 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEPHS2 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SEPHS2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPHS2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmid: SEPHS2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPHS2 (see all 7)
    OriGene shRNA RFP: SEPHS2
    OriGene siRNA: SEPHS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPHS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SEPHS2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SEPHS2
    Sirion Biotech Customized adenovirus for overexpression of SEPHS2 
    Sirion Biotech Customized adenovirus for potent knockdown of SEPHS2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPHS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPHS2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPHS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPHS2 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2


    Pathways & Interactions
    for SEPHS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selenium Metabolism and Selenoproteins
    		Selenium Metabolism and Selenoproteins1.00
    2Selenium Pathway
    		Selenium Pathway1.00
    3Selenocompound metabolism
    		Selenocompound metabolism1.00
    4Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for SEPHS2 
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


    2         Kegg Pathways  (Kegg details for SEPHS2):
        Selenocompound metabolism
    Metabolic pathways


    SEPHS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEPHS2

    1 Interacting protein for SEPHS2 (Q996113) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016260selenocysteine biosynthetic process NAS8986768

    SEPHS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEPHS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEPHS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEPHS2

    9 HMDB Compounds for SEPHS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoroselenoic acidMonoselenophosphoric acid (see all 5)25758-66-1--
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--
    SelenophosphatePhosphorus selenide (PSe) (see all 4)289702-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    4 Novoseek chemical compound relationships for SEPHS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenophosphate 97.6 16 15534230 (1), 16508009 (1), 18790070 (1), 17346238 (1) (see all 8)
    selenocysteine 89.7 3 15534230 (2), 8986768 (1)
    selenium 73.2 6 15534230 (1), 17916946 (1), 19136613 (1)
    atp 26.8 1 17916946 (1)

    Search CenterWatch for drugs/clinical trials and news about SEPHS2 / SPS2 

    Transcripts
    for SEPHS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEPHS2 gene: 
    NM_012248.2  

    Unigene Cluster for SEPHS2:

    Selenophosphate synthetase 2
    Hs.118725  [show with all ESTs]
    Unigene Representative Sequence: NM_012248
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478753(uc021tgl.1 uc021tgl.1) ENST00000478753(uc021tgl.1 uc021tgl.1)
    ENST00000542752(uc002dyh.1) ENST00000500504

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SEPHS2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEPHS2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SEPHS2 (see all 16):
    hsa-miR-3655 hsa-miR-3614-3p hsa-miR-578 hsa-miR-520a-5p hsa-miR-133a hsa-miR-1914 hsa-miR-450b-5p hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmid: SEPHS2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEPHS2 (see all 7)
    OriGene shRNA RFP: SEPHS2
    OriGene siRNA: SEPHS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEPHS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SEPHS2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEPHS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEPHS2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEPHS2 (NM_012248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEPHS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEPHS2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPHS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPHS2

    Additional cDNA sequence: 

    AK092003.1 AK093889.1 AK303275.1 BC002381.2 BC016643.1 U43286.1 

    11 DOTS entries:

    DT.218746  DT.95239105  DT.100825505  DT.91758013  DT.100638562  DT.100680963  DT.95363464  DT.100798908 
    DT.95363484  DT.100825508  DT.95363485 

    24/338 AceView cDNA sequences (see all 338):

    AI039116 AI087878 BM970509 BM722868 AA595179 AW192372 BX382972 AI692231 
    BX425316 AA877291 AA725394 AI080276 BM834490 W69359 AK093889 AL557600 
    CN484377 AL120777 BF219998 BQ000405 AL531235 AI922715 AI370847 CA307427 

    GeneLoc Exon Structure


    Expression
    for SEPHS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEPHS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGCCACAGA
    SEPHS2 Expression
    About this image

    SEPHS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SEPHS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEPHS2

    SOURCE GeneReport for Unigene cluster: Hs.118725
        SABiosciences Custom PCR Arrays for SEPHS2
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEPHS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEPHS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEPHS2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEPHS2

    Orthologs
    for SEPHS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SEPHS2 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SEPHS26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 2(89776676-89783107)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.58252 Transcribed sequence with moderate similarity to protein more 76.14(n)    CF152055.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sps21 selenophosphate synthetase 2 67.53(n)
    74.59(a)    		   352933  NM_001004295.2  NP_001004295.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SelD6
    Sps26
    		 Selenophosphate synthetase 2
    		 65(a)
    44(a)
    		 1 ↔ many
    possible ortholog
    		 2R(10156275-10158159)
    2L(10342594-10344223)
    worm
    (Caenorhabditis elegans)    		 Secernentea seld-11 Protein SELD-1 52.92(n)
    50.97(a)    		   189912  NM_070203.1  NP_502604.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria selD6
    		 selenophosphate synthase
    		 26(a)
    		 1 → many
    		 Chromosome(1844989-1846032)


    ENSEMBL Gene Tree for SEPHS2 (if available)
    TreeFam Gene Tree for SEPHS2 (if available) 

    Paralogs
    for SEPHS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEPHS2 gene
    SEPHS12  
    1 SIMAP similar gene for SEPHS2 using alignment to 4 protein entries:     SPS2_HUMAN (see all proteins):
    SEPHS1

    SEPHS2 for paralogs           About GeneDecksing



    Genomic Variants
    for SEPHS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/69 NCBI SNPs in SEPHS2 are shown (see all 69)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1467679421,2
    		--30454501(+) CCTGCA/GTAGGT 1 -- ds50010--------
    rs1869388721,2
    		--30454515(+) AGGCAA/GTCACC 1 -- ds50010--------
    rs1915283401,2
    		--30454524(+) CCTGGC/TTGTGT 1 -- ds50010--------
    rs1489016841,2
    		--30454758(+) AACCCA/TTGGGG 1 -- ds50010--------
    rs1124774881,2
    		--30454764(+) TGGGGC/TGTATG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1435647921,2
    		--30454854(+) CATCAC/GGGAAA 1 -- ds50010--------
    rs1509794511,2
    		--30454877(+) TGCTAC/TACCAG 1 -- ds50010--------
    rs1148883631,2
    		F--30454904(+) GGTTCG/ATTTTA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1408111031,2
    		--30455064(+) GGCCTC/GGGCTC 1 -- ut310--------
    rs1887453841,2
    		--30455269(+) CTCTTA/CACAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SEPHS2 (30454952 - 30457502 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEPHS2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SEPHS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEPHS2 for disorders           About GeneDecksing

    OMIM gene information: 606218    OMIM disorders: --

    7 diseases for SEPHS2:    About MalaCards
    non-small cell lung carcinoma    lung carcinoma    lung adenocarcinoma    adenocarcinoma
    carcinoma    hepatitis    malaria


    Export disorders for SEPHS2 gene to outside databases

    Publications
    for SEPHS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEPHS2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SEPHS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? (PubMed id 8986768)1, 2, 9 Guimaraes M.J....Zlotnik A. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PubMed id 10608886)1, 3 Lescure A.... Krol A. (1999)
    4. A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies. (PubMed id 7588067)1, 2 Guimaraes M.J.... McClanahan T. (1995)
    5. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PubMed id 15534230)1, 9 Tamura T....Inagaki K. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SEPHS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
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    Genome Databases showing SEPHS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22928 HGNC: 19686 AceView: SEPHS2 Ensembl:ENSG00000179918 euGenes: HUgn22928
    ECgene: SEPHS2 Kegg: 22928 H-InvDB: SEPHS2

    Other Databases showing SEPHS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SEPHS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEPHS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SEPHS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEPHS2 gene:
    Search GeneIP for patents involving SEPHS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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