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SEPHS1 Gene

protein-coding   GIFtS: 60
GCID: GC10M013360

Selenophosphate Synthetase 1

  See SEPHS1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenophosphate Synthetase 11 2     Selenide, Water Dikinase 12
SPS12 3 5     Selenophosphate Synthetase 1 +E92
Selenium Donor Protein 12 3     Selenophosphate Synthetase 1 +E9a2
Selenophosphate Synthase 12 3     Selenophosphate Synthetase 1 Delta E22
SELD2 3     Selenophosphate Synthetase 1 Delta E82
SPS2 3     Selenophosphate Synthetase 1 Major2
EC 2.7.9.33 8     

External Ids:    HGNC: 196851   Entrez Gene: 229292   Ensembl: ENSG000000864757   OMIM: 6009025   UniProtKB: P499033   

Export aliases for SEPHS1 gene to outside databases

Previous GC identifers: GC10M013364 GC10M013400 GC10M013272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEPHS1 Gene:
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the
selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at
in-frame UGA codons. (provided by RefSeq, Sep 2010)

GeneCards Summary for SEPHS1 Gene:
SEPHS1 (selenophosphate synthetase 1) is a protein-coding gene. Diseases associated with SEPHS1 include schizophrenia. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is SEPHS2.

UniProtKB/Swiss-Prot: SPS1_HUMAN, P49903
Function: Synthesizes selenophosphate from selenide and ATP

Gene Wiki entry for SEPHS1 (Selenophosphate synthetase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEPHS1 gene promoter:
         STAT5B   p53   STAT4   STAT1beta   STAT5A   STAT1alpha   E47   c-Ets-1   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEPHS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEPHS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p14

SEPHS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPHS1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M013360:  view genomic region     (about GC identifiers)

Start:
13,359,424 bp from pter      End:
13,390,298 bp from pter
Size:
30,875 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPS1_HUMAN, P49903 (See protein sequence)
Recommended Name: Selenide, water dikinase 1  
Size: 392 amino acids; 42911 Da
Subunit: Homodimer (isoform 1, isoform 2, isoform 3 and isoform 4). Heterodimer of isoform 1 and isoform 3.
Heterodimer of isoform 2 and isoform 4
Caution: The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However,
as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site
Sequence caution: Sequence=AAA87567.1; Type=Frameshift; Positions=377;
2 PDB 3D structures from and Proteopedia for SEPHS1:
3FD5 (3D)        3FD6 (3D)    
Secondary accessions: B4DWK0 D3DRS9 D6PSQ9 Q5T5U8 Q5T5U9 Q9BVT4
Alternative splicing: 4 isoforms:  P49903-1   P49903-2   P49903-3   P49903-4   

Explore the universe of human proteins at neXtProt for SEPHS1: NX_P49903

Explore proteomics data for SEPHS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys139
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SEPHS1 (P49903) (see all 19)
     VTGGQTV  PIVDDPY  KACGNMF  RESFNPE 


    See SEPHS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182531.1  NP_001182533.1  NP_036379.2  

    ENSEMBL proteins: 
     ENSP00000367893   ENSP00000367877   ENSP00000401732   ENSP00000400418   ENSP00000442768  
     ENSP00000441119  

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    antibodies-online peptides for SEPHS1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016188 PurM_N-like
     IPR000728 AIR_synth_N_dom
     IPR010918 AIR_synth_C_dom
     IPR004536 SelD

    Graphical View of Domain Structure for InterPro Entry P49903

    ProtoNet protein and cluster: P49903

    2 Blocks protein domains:
    IPB000728 AIR synthase related protein
    IPB010918 AIR synthase related protein


    UniProtKB/Swiss-Prot: SPS1_HUMAN, P49903
    Similarity: Belongs to the selenophosphate synthase 1 family. Class II subfamily


    Find genes that share domains with SEPHS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPS1_HUMAN, P49903
    Function: Synthesizes selenophosphate from selenide and ATP
    Catalytic activity: ATP + selenide + H(2)O = AMP + selenophosphate + phosphate
    Enzyme regulation: Activated by phosphate ions and by potassium ions

         Enzyme Number (IUBMB): EC 2.7.9.31 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004756selenide, water dikinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding TAS7665581
         
    Find genes that share ontologies with SEPHS1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Sephs1 (no phenotypes)

    Find genes that share phenotypes with SEPHS1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEPHS1

    miRNA
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    miRTarBase miRNAs that target SEPHS1:
    hsa-mir-484 (MIRT041988), hsa-mir-615-3p (MIRT040065), hsa-mir-193b-3p (MIRT016476), hsa-mir-221-3p (MIRT046882)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPS1_HUMAN, P49903: Isoform 1: Cell membrane. Nucleus membrane
    SPS1_HUMAN, P49903: Isoform 2: Cytoplasm
    SPS1_HUMAN, P49903: Isoform 3: Cytoplasm
    SPS1_HUMAN, P49903: Isoform 4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with SEPHS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEPHS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Selenocompound metabolism
    Selenocompound metabolism


    Find genes that share SuperPaths with SEPHS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for SEPHS1):
        Selenocompound metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEPHS1
    Interactions:

        Search GeneGlobe Interaction Network for SEPHS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEPHS1 (P499033 ENSP000003678934) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRAFP150563, ENSP000002886024I2D: score=1 STRING: ENSP00000288602
    EIF1BO607393, ENSP000002329054I2D: score=1 STRING: ENSP00000232905
    ROS1P089223, ENSP000003574944I2D: score=1 STRING: ENSP00000357494
    TNFRSF10DQ9UBN63, ENSP000003102634I2D: score=1 STRING: ENSP00000310263
    C9orf9Q96E403, ENSP000002985464I2D: score=4 STRING: ENSP00000298546
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS7665581

    Find genes that share ontologies with SEPHS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SEPHS1 (SPS1)

    8 HMDB Compounds for SEPHS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Hydrogen selenideDihydrogen monoselenide (see all 7)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoroselenoic acidMonoselenophosphoric acid (see all 5)25758-66-1--
    Seleniumselenium (see all 5)7782-49-2--
    SelenophosphatePhosphorus selenide (PSe) (see all 4)289702-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    8 Novoseek inferred chemical compound relationships for SEPHS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenophosphate 99.1 98 9398525 (3), 15354357 (3), 19477186 (3), 15653770 (3) (see all 37)
    selenocysteine 91.5 24 8986768 (2), 15534230 (2), 16086848 (2), 17346238 (2) (see all 10)
    selenium 84 72 15653770 (6), 8829132 (3), 7665581 (3), 17346238 (3) (see all 27)
    selenite 64.6 7 15534230 (3), 17142313 (1), 9363997 (1)
    atp 48.3 22 9169026 (2), 7665581 (2), 8144648 (1), 15534230 (1) (see all 13)
    cysteine 41.4 1 17054778 (1)
    formate 39.4 2 15534230 (1), 17054778 (1)
    serine 7.68 2 17194211 (1), 17916946 (1)



    Find genes that share compounds with SEPHS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEPHS1 gene (3 alternative transcripts): 
    NM_001195602.1  NM_001195604.1  NM_012247.4  

    Unigene Cluster for SEPHS1:

    Selenophosphate synthetase 1
    Hs.124027  [show with all ESTs]
    Unigene Representative Sequence: NM_012247
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327347(uc001imh.3 uc010qbs.2 uc001imk.3 uc010qbt.2 uc021pnc.1 uc021pnd.1 uc009xje.3)
    ENST00000378614 ENST00000413411 ENST00000425947 ENST00000494329 ENST00000537130
    ENST00000545675
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    Additional mRNA sequence: 

    AK125066.1 AK297129.1 AK301568.1 AK309829.1 BC000941.1 BC063816.1 BC064610.1 GU954545.1 
    GU954546.1 GU954547.1 GU954548.1 GU954549.1 

    14 DOTS entries:

    DT.449406  DT.101984613  DT.101968157  DT.100813791  DT.97860376  DT.100695261  DT.95291291  DT.121230762 
    DT.99931623  DT.100813788  DT.121230748  DT.95349843  DT.121290122  DT.92035413 

    Selected AceView cDNA sequences (see all 377):

    CD243578 AI124052 BM455684 BU685041 D17231 CR626255 AL138318 NM_012247 
    BF515248 BM995591 CR590975 AA424248 R17607 BM918147 BU191761 AI499770 
    BQ219069 AA257082 BC000941 BM560860 BU625689 CR616353 AI918108 AI631534 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:        -                       -                                                         
    SP2:                                -                                                         
    SP3:                                                                                          
    SP4:                                -                                                         
    SP5:                                -                                                         


    ECgene alternative splicing isoforms for SEPHS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEPHS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGCAGTA
    SEPHS1 Expression
    About this image


    SEPHS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)
    SEPHS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEPHS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124027

    UniProtKB/Swiss-Prot: SPS1_HUMAN, P49903
    Tissue specificity: Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and
    then decreased. Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SEPHS1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sephs11 , 5 selenophosphate synthetase 11, 5 89.8(n)1
    99.49(a)1
      2 (3.02 cM)5
    1090791  NM_175400.61  NP_780609.41 
     48815645 
    chicken
    (Gallus gallus)
    Aves SEPHS11 selenophosphate synthetase 1 82.06(n)
    99.49(a)
      426612  NM_001164084.1  NP_001157556.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEPHS16
    selenophosphate synthetase 1
    98(a)
    1 ↔ 1
    5(90032611-90053947)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689222 hypothetical protein MGC68922 80.53(n)    BC057731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc49b092 wufc49b09 79.4(n)   324947  BC045302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SelD1 Selenide,water dikinase 67.66(n)
    72.9(a)
      36587  NM_166045.1  NP_725374.1 
    worm
    (Caenorhabditis elegans)
    Secernentea seld-11 seld-1 55.98(n)
    53.82(a)
      189912  NM_070203.1  NP_502604.1 


    ENSEMBL Gene Tree for SEPHS1 (if available)
    TreeFam Gene Tree for SEPHS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEPHS1 gene
    SEPHS22  
    1 SIMAP similar gene for SEPHS1 using alignment to 3 protein entries:     SPS1_HUMAN (see all proteins):
    SEPHS2

    Find genes that share paralogs with SEPHS1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SEPHS1 (see all 10)
    PGOHUM00000246933 PGOHUM00000248825 PGOHUM00000240268 PGOHUM00000241057 PGOHUM00000260030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SEPHS1 (see all 770)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22536171,2
    C--13358961(-) ATAGAG/AGTTGC 3 -- int113Minor allele frequency- A:0.00NA WA CSA EA 375
    rs22536191,2
    C,F--13358988(-) GGCACG/AAGAAT 3 -- int113Minor allele frequency- A:0.07NA WA CSA EA 375
    rs1465533021,2
    --13359130(+) CACCTC/TGGCCT 3 -- int10--------
    rs1411797791,2
    C--13359228(+) TTACAC/TGGACC 3 -- int10--------
    rs1889330301,2
    --13359358(+) TCTCAC/TGGCAC 3 -- int10--------
    rs727813921,2
    C,F--13359359(+) CTCACG/AGCACA 3 -- int11Minor allele frequency- A:0.08NA 120
    rs1498068691,2
    --13359367(+) ACAGGA/CTACAC 3 -- int10--------
    rs563115191,2
    C--13359371(+) GCTACA/GCTGAA 3 -- int10--------
    rs1923697131,2
    --13359449(+) TTTCCA/GACACA 3 -- ut310--------
    rs1457494071,2
    --13359499(+) CAACAC/TCTCTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SEPHS1 (13359424 - 13390298 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SEPHS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010238CNV Deletion20482838
    esv2733373CNV Deletion23290073
    esv2733384CNV Deletion23290073
    nsv831788CNV Loss17160897
    dgv127n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEPHS1
    DNA2.0 Custom Variant and Variant Library Synthesis for SEPHS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600902    OMIM disorders: --

    1 disease for SEPHS1:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with SEPHS1           About GenesLikeMe

    2 Novoseek inferred disease relationships for SEPHS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 35.1 2 15534230 (2)
    schizophrenia 0 5 7739414 (3), 8218612 (1)

    Genetic Association Database (GAD): SEPHS1
    Human Genome Epidemiology (HuGE) Navigator: SEPHS1 (1 document)

    Export disorders for SEPHS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEPHS1 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with SEPHS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. (PubMed id 7665581)1, 2, 3, 9 Low S.C.... Berry M.J. (J. Biol. Chem. 1995)
    2. Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns. (PubMed id 20471958)1, 2 Kim J.Y.... Lee B.J. (Biochem. Biophys. Res. Commun. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. (PubMed id 15534230)1, 9 Tamura T....Inagaki K. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Crystal structures of catalytic intermediates of human selenophosphate synthetase 1. (PubMed id 19477186)2, 9 Wang K.T.... Su X.D. (J. Mol. Biol. 2009)
    7. p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. (PubMed id 16786570)1, 9 Chung H.J....Bae S. (J. Cell. Physiol. 2006)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand. (PubMed id 23112913)1 Gentschew L....Ferguson L.R. (Nutrients 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22929 HGNC: 19685 AceView: SEPHS1 Ensembl:ENSG00000086475 euGenes: HUgn22929
    ECgene: SEPHS1 Kegg: 22929 H-InvDB: SEPHS1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEPHS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEPHS1 gene:
    Search GeneIP for patents involving SEPHS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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