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Aliases for SEPHS1 Gene

Aliases for SEPHS1 Gene

  • Selenophosphate Synthetase 1 2 3 5
  • Selenophosphate Synthase 1 3 4
  • Selenium Donor Protein 1 3 4
  • EC 2.7.9.3 4 61
  • SELD 3 4
  • SPS1 3 4
  • SPS 3 4
  • Selenophosphate Synthetase 1 Delta E2 3
  • Selenophosphate Synthetase 1 Delta E8 3
  • Selenophosphate Synthetase 1 Major 3
  • Selenophosphate Synthetase 1 +E9a 3
  • Selenophosphate Synthetase 1 +E9 3
  • Selenide, Water Dikinase 1 3
  • Selenide, Water Dikinase 2

External Ids for SEPHS1 Gene

Previous GeneCards Identifiers for SEPHS1 Gene

  • GC10M013364
  • GC10M013400
  • GC10M013272
  • GC10M013360

Summaries for SEPHS1 Gene

Entrez Gene Summary for SEPHS1 Gene

  • This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]

GeneCards Summary for SEPHS1 Gene

SEPHS1 (Selenophosphate Synthetase 1) is a Protein Coding gene. Among its related pathways are Selenocompound metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is SEPHS2.

UniProtKB/Swiss-Prot for SEPHS1 Gene

  • Synthesizes selenophosphate from selenide and ATP.

Gene Wiki entry for SEPHS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEPHS1 Gene

Genomics for SEPHS1 Gene

Regulatory Elements for SEPHS1 Gene

Enhancers for SEPHS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F013316 0.2 ENCODE 11.8 +31.5 31479 0.1 SEPHS1 UCMA C8orf59P1 GC10M013327 PIR32930
GH10F013450 0.6 ENCODE 11.8 -102.0 -101998 0.2 GATA3 CEBPB EP300 SP7 SEPHS1 LOC105376420 ENSG00000202508
GH10F013439 0.7 Ensembl ENCODE 11.5 -92.1 -92103 1.2 ZNF76 KLF17 ARID4B ZNF48 ZNF2 RAD21 CHAMP1 GLIS2 SCRT2 ZNF143 BEND7 LOC105376421 SEPHS1 LOC105376420 ENSG00000202508
GH10F013395 0.6 ENCODE 11.2 -47.4 -47448 0.3 BCL11A POU5F1 SEPHS1 LOC105376419 LOC105376420
GH10F013403 0.2 ENCODE 11 -56.3 -56269 1.6 ATF1 ARNT GATA2 FOS JUNB NCOA1 SMARCB1 CREB3 MBD2 MEF2D ENSG00000239665 SEPHS1 LOC105376420 LOC105376419
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SEPHS1 on UCSC Golden Path with GeneCards custom track

Promoters for SEPHS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000350926 298 4801 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 ETS1 YY1 GLIS2

Genomic Location for SEPHS1 Gene

Chromosome:
10
Start:
13,317,424 bp from pter
End:
13,348,298 bp from pter
Size:
30,875 bases
Orientation:
Minus strand

Genomic View for SEPHS1 Gene

Genes around SEPHS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEPHS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEPHS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEPHS1 Gene

Proteins for SEPHS1 Gene

  • Protein details for SEPHS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49903-SPS1_HUMAN
    Recommended name:
    Selenide, water dikinase 1
    Protein Accession:
    P49903
    Secondary Accessions:
    • B4DWK0
    • D3DRS9
    • D6PSQ9
    • Q5T5U8
    • Q5T5U9
    • Q9BVT4

    Protein attributes for SEPHS1 Gene

    Size:
    392 amino acids
    Molecular mass:
    42911 Da
    Quaternary structure:
    • Homodimer (isoform 1, isoform 2, isoform 3 and isoform 4). Heterodimer of isoform 1 and isoform 3. Heterodimer of isoform 2 and isoform 4.
    SequenceCaution:
    • Sequence=AAA87567.1; Type=Frameshift; Positions=377; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SEPHS1 Gene

    Alternative splice isoforms for SEPHS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEPHS1 Gene

Post-translational modifications for SEPHS1 Gene

  • Ubiquitination at Lys 139
  • Modification sites at PhosphoSitePlus

Domains & Families for SEPHS1 Gene

Graphical View of Domain Structure for InterPro Entry

P49903

UniProtKB/Swiss-Prot:

SPS1_HUMAN :
  • Belongs to the selenophosphate synthase 1 family. Class II subfamily.
Family:
  • Belongs to the selenophosphate synthase 1 family. Class II subfamily.
genes like me logo Genes that share domains with SEPHS1: view

No data available for Gene Families for SEPHS1 Gene

Function for SEPHS1 Gene

Molecular function for SEPHS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + selenide + H(2)O = AMP + selenophosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphate ions and by potassium ions.
UniProtKB/Swiss-Prot Function:
Synthesizes selenophosphate from selenide and ATP.

Enzyme Numbers (IUBMB) for SEPHS1 Gene

Gene Ontology (GO) - Molecular Function for SEPHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004756 selenide, water dikinase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA,TAS --
GO:0005525 GTP binding TAS 7665581
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with SEPHS1: view
genes like me logo Genes that share phenotypes with SEPHS1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEPHS1

miRNA for SEPHS1 Gene

miRTarBase miRNAs that target SEPHS1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEPHS1 Gene

Localization for SEPHS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEPHS1 Gene

Isoform 1: Cell membrane. Nucleus membrane.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEPHS1 Gene COMPARTMENTS Subcellular localization image for SEPHS1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SEPHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with SEPHS1: view

Pathways & Interactions for SEPHS1 Gene

genes like me logo Genes that share pathways with SEPHS1: view

Pathways by source for SEPHS1 Gene

1 BioSystems pathway for SEPHS1 Gene
2 KEGG pathways for SEPHS1 Gene

Gene Ontology (GO) - Biological Process for SEPHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7665581
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SEPHS1: view

No data available for SIGNOR curated interactions for SEPHS1 Gene

Drugs & Compounds for SEPHS1 Gene

(9) Drugs for SEPHS1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Selenium Pharma 175

(6) Additional Compounds for SEPHS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Selenophosphate
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenoxo-phosphino
289702-60-9
Hydrogen selenide
  • Dihydrogen monoselenide
  • Dihydrogen selenide
  • Hydrogen selenide
  • Selane
  • Selenium dihydride
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Phosphoroselenoic acid
  • Monoselenophosphoric acid
  • Selenophosphoric acid
  • SePO3
  • Trihydroxidoselenidophosphorus
  • [P(OH)3Se]
25758-66-1
genes like me logo Genes that share compounds with SEPHS1: view

Transcripts for SEPHS1 Gene

Unigene Clusters for SEPHS1 Gene

Selenophosphate synthetase 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEPHS1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: -
SP3:
SP4: -
SP5: -

Relevant External Links for SEPHS1 Gene

GeneLoc Exon Structure for
SEPHS1
ECgene alternative splicing isoforms for
SEPHS1

Expression for SEPHS1 Gene

mRNA expression in normal human tissues for SEPHS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEPHS1 Gene

This gene is overexpressed in Salivary gland (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEPHS1 Gene



Protein tissue co-expression partners for SEPHS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEPHS1 Gene:

SEPHS1

SOURCE GeneReport for Unigene cluster for SEPHS1 Gene:

Hs.124027

mRNA Expression by UniProt/SwissProt for SEPHS1 Gene:

P49903-SPS1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased. Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased.
genes like me logo Genes that share expression patterns with SEPHS1: view

Primer Products

No data available for mRNA differential expression in normal tissues for SEPHS1 Gene

Orthologs for SEPHS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SEPHS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPHS1 34 35
  • 99.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SEPHS1 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEPHS1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sephs1 34
  • 91.16 (n)
dog
(Canis familiaris)
Mammalia SEPHS1 34 35
  • 90.9 (n)
cow
(Bos Taurus)
Mammalia SEPHS1 34 35
  • 90.48 (n)
mouse
(Mus musculus)
Mammalia Sephs1 34 16 35
  • 89.8 (n)
chicken
(Gallus gallus)
Aves SEPHS1 34 35
  • 82.06 (n)
lizard
(Anolis carolinensis)
Reptilia SEPHS1 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sephs1 34
  • 80.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68922 34
zebrafish
(Danio rerio)
Actinopterygii sephs1 34 35
  • 79 (n)
wufc49b09 34
fruit fly
(Drosophila melanogaster)
Insecta SelD 34 35
  • 67.66 (n)
Sps2 35
  • 43 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007967 34
  • 67.03 (n)
worm
(Caenorhabditis elegans)
Secernentea seld-1 34 35
  • 55.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8569 35
  • 57 (a)
OneToMany
Species where no ortholog for SEPHS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEPHS1 Gene

ENSEMBL:
Gene Tree for SEPHS1 (if available)
TreeFam:
Gene Tree for SEPHS1 (if available)

Paralogs for SEPHS1 Gene

Paralogs for SEPHS1 Gene

(1) SIMAP similar genes for SEPHS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEPHS1: view

Variants for SEPHS1 Gene

Sequence variations from dbSNP and Humsavar for SEPHS1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1004621 -- 13,346,584(-) ATTCT(C/G)GTCTC intron-variant, upstream-variant-2KB
rs1005089 -- 13,345,295(+) ACACC(A/G)TGCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10128117 -- 13,342,400(+) ACACC(A/G/T)TGAAA intron-variant
rs10128408 -- 13,342,370(+) GAGCT(C/G)AGGAG intron-variant
rs10508459 -- 13,321,046(+) TATAA(A/T)GGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEPHS1 Gene

Variant ID Type Subtype PubMed ID
dgv127n67 CNV gain 20364138
esv1010238 CNV deletion 20482838
esv2733373 CNV deletion 23290073
esv2733384 CNV deletion 23290073
esv3578645 CNV loss 25503493
nsv1068281 CNV deletion 25765185
nsv1143493 CNV deletion 24896259
nsv831788 CNV loss 17160897
nsv947742 CNV duplication 23825009
nsv951251 CNV deletion 24416366

Variation tolerance for SEPHS1 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEPHS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEPHS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEPHS1 Gene

Disorders for SEPHS1 Gene

Relevant External Links for SEPHS1

Genetic Association Database (GAD)
SEPHS1
Human Genome Epidemiology (HuGE) Navigator
SEPHS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEPHS1

No disorders were found for SEPHS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEPHS1 Gene

Publications for SEPHS1 Gene

  1. Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. (PMID: 7665581) Low S.C. … Berry M.J. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns. (PMID: 20471958) Kim J.Y. … Lee B.J. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  3. Crystal structures of catalytic intermediates of human selenophosphate synthetase 1. (PMID: 19477186) Wang K.T. … Su X.D. (J. Mol. Biol. 2009) 4 22 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. (PMID: 16786570) Chung H.J. … Bae S. (J. Cell. Physiol. 2006) 3 22 64

Products for SEPHS1 Gene

Sources for SEPHS1 Gene

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