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SEP15 Gene

protein-coding   GIFtS: 47
GCID: GC01M087328

15 KDa Selenoprotein


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 2

Aliases
15 KDa Selenoprotein2

External Ids:    Entrez Gene: 94032   Ensembl: ENSG000001832917   OMIM: 6062545   UniProtKB: O606133   
ORGUL members:         

Export aliases for SEP15 gene to outside databases

Previous GC identifers: GC01M087830 GC01M086497 GC01M086620 GC01M086750 GC01M087040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEP15 Gene:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The
selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for
the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this
selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is
localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively
spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SEP15 Gene:
SEP15 is a protein-coding gene. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot: SEP15_HUMAN, O60613
Function: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to
the quality control of protein folding in the endoplasmic reticulum (By similarity)

Gene Wiki entry for SEP15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEP15 gene promoter:
         MZF-1   POU2F1   POU2F1a   RREB-1   AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p22.3   

SEP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEP15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M087328:  view genomic region     (about GC identifiers)

Start:
87,328,128 bp from pter      End:
87,380,107 bp from pter
Size:
51,980 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEP15_HUMAN, O60613 (See protein sequence)
Recommended Name: 15 kDa selenoprotein precursor  
Size: 162 amino acids; 17790 Da
Subunit: Forms a tight complex with UGGT1/UGCGL1 (By similarity)
Mass spectrometry: Mass=14870; Method=Electrospray; Range=26-162; Source=PubMed:9535873;
Mass spectrometry: Mass=14830; Method=MALDI; Range=26-162; Source=PubMed:9535873;
Sequence caution: Sequence=AAH05294.3; Type=Erroneous initiation; Sequence=AAH16359.3; Type=Erroneous initiation;
Sequence=AAH21697.3; Type=Erroneous initiation;
Secondary accessions: Q4GZG7 Q8WU00 Q9BS64 Q9GZW0 Q9NR01
Alternative splicing: 2 isoforms:  O60613-1   O60613-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEP15: NX_O60613

Explore proteomics data for SEP15 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004252.2  NP_976086.1  

    ENSEMBL proteins: 
     ENSP00000328729   ENSP00000359585   ENSP00000383810  

    SEP15 Human Recombinant Protein Products:

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    Novus Biologicals SEP15 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SEP15
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SEP15 

     
    antibodies-online proteins for SEP15 (4 products) 

     
    antibodies-online peptides for SEP15

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    antibodies-online antibodies for SEP15 (5 products) 

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    antibodies-online kits for SEP15 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014912 Sep15_SelM
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry O60613

    ProtoNet protein and cluster: O60613

    UniProtKB/Swiss-Prot: SEP15_HUMAN, O60613
    Similarity: Belongs to the selenoprotein M/SEP15 family


    Find genes that share domains with SEP15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEP15_HUMAN, O60613
    Function: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to
    the quality control of protein folding in the endoplasmic reticulum (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008430selenium binding IDA9535873
         
    Find genes that share ontologies with SEP15           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sep15):
     cellular  liver/biliary system  vision/eye 

    Find genes that share phenotypes with SEP15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sep15tm1Vgla for SEP15

       genOway: Develop your customized and physiologically relevant rodent model for SEP15

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEP15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEP15_HUMAN, O60613: Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its
    retention in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IDA11278576

    Find genes that share ontologies with SEP15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEP15 About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway


    1 BioSystems Pathway for SEP15
        Selenium Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEP15
    Interactions:

        Search GeneGlobe Interaction Network for SEP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SEP15 (O606132, 3 ENSP000003287294) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-8270088 I2D: score=2 STRING: ENSP00000352257
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    BAMBIQ131452, 3, ENSP000003646834MINT-8270077 I2D: score=2 STRING: ENSP00000364683
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051084'de novo' posttranslational protein folding TAS11278576

    Find genes that share ontologies with SEP15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEP15

    2 HMDB Compounds for SEP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--

    1 Novoseek inferred chemical compound relationship for SEP15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 75.3 15 18239845 (6), 15107826 (4), 20378690 (1), 11280803 (1) (see all 5)



    Find genes that share compounds with SEP15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEP15 gene (2 alternative transcripts): 
    NM_004261.3  NM_203341.1  

    Unigene Cluster for SEP15:

    15 kDa selenoprotein
    Hs.362728  [show with all ESTs]
    Unigene Representative Sequence: NM_004261
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331835(uc021oph.1 uc021opi.1) ENST00000370554 ENST00000469566
    ENST00000401030 ENST00000497861 ENST00000467557
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEP15
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SEP15
      QuantiFast Probe-based Assays in human, mouse, rat SEP15

    Additional mRNA sequence: 

    AF051894.1 AF288991.1 AK225252.1 AK225640.1 AL833575.1 BC005294.1 BC016359.1 BC021697.1 

    21 DOTS entries:

    DT.40118212  DT.87017320  DT.100881291  DT.99986600  DT.100881286  DT.100881293  DT.100881284  DT.92465610 
    DT.100881288  DT.100881270  DT.95375264  DT.121398378  DT.121398413  DT.92465614  DT.121398379  DT.121398387 
    DT.121398465  DT.121398514  DT.95375249  DT.121398380  DT.91892612 

    Selected AceView cDNA sequences (see all 777):

    BP338713 AW957637 BM767292 BM479983 BU172227 AL559824 AI140744 AI625408 
    NM_203341 AA937757 CB530068 BM835343 CB853496 CB217091 AW275158 AI879578 
    BQ935657 BM973766 BM853927 BE504467 W32254 CN483893 AA663419 BM761203 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEP15 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                            -                             -                                       
    SP2:                    -     -     -     -     -           -                 -                                       
    SP3:                                            -           -                 -                                       
    SP4:                    -     -     -     -     -           -           -     -                                       
    SP5:                                            -           -           -     -                                       



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTGTGC
    SEP15 Expression
    About this image

    SEP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.362728

    UniProtKB/Swiss-Prot: SEP15_HUMAN, O60613
    Tissue specificity: Higher levels in prostate and thyroid gland

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEP15 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sep151 , 5 selenoprotein1, 5 87.65(n)1
    92.59(a)1
      3 (68.94 cM)5
    936841  NM_053102.21  NP_444332.11 
     1445703045 
    chicken
    (Gallus gallus)
    Aves SEP151 15 kDa selenoprotein 79.29(n)
    87.86(a)
      424521  NM_001012926.2  NP_001012944.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    82(a)
    71(a)
    many → 1
    many → 1
    4(97332961-97369109)
    4(97374490-97376336)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480639942   -- 77.6(n)    48063994 
    zebrafish
    (Danio rerio)
    Actinopterygii sep152 selenoprotein, 15 kDa 79.22(n)   352923  AY221263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74841 CG7484 49.06(n)
    50.7(a)
      39969  NM_140743.2  NP_649000.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y76B12C.31 Y76B12C.3 52.68(n)
    41.96(a)
      176999  NM_067751.3  NP_500152.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G057201 AT1G05720 45.06(n)
    32.41(a)
      837079  NM_100452.4  NP_563747.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08945001 Os01g0894500 47.79(n)
    41.26(a)
      4324963  NM_001051604.1  NP_001045069.1 


    ENSEMBL Gene Tree for SEP15 (if available)
    TreeFam Gene Tree for SEP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEP15 (see all 987)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160205671,2
    C,F--87327698(+) GAAGTC/TGGGAG 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1832768661,2
    --87327701(+) GTCGGA/GAGTTC 2 -- ds50010--------
    rs1511452041,2
    --87327738(+) ACCCCA/GTCTAT 2 -- ds50010--------
    rs5016611,2
    C,F,A,H--87327858(+) gctgaG/Aatcac 2 -- ds50015Minor allele frequency- A:0.44NA WA CSA 9
    rs1504961471,2
    --87327863(+) GATCAC/TGCCAT 2 -- ds50010--------
    rs1861255051,2
    --87327864(+) ATCACA/GCCATT 2 -- ds50010--------
    rs1163610421,2
    F--87327871(+) CATTGC/TACTCC 2 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1910699761,2
    --87327904(+) ACTCCA/GTCTCA 2 -- ds50010--------
    rs1820541591,2
    --87327917(+) AAATAA/CATACA 2 -- ds50010--------
    rs1878469751,2
    --87327933(+) ACATAC/TGTACA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SEP15 (87328128 - 87380107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEP15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1340746CNV Insertion17803354
    nsv1777CNV Insertion18451855

    Human Gene Mutation Database (HGMD): SEP15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEP15
    DNA2.0 Custom Variant and Variant Library Synthesis for SEP15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606254    OMIM disorders: --


    Find genes that share disorders with SEP15           About GenesLikeMe

    2 Novoseek inferred disease relationships for SEP15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 19.9 4 15107826 (1), 11280803 (1), 19327385 (1)
    tumors 0 3 15107826 (1), 11280803 (1)

    Genetic Association Database (GAD): SEP15
    Human Genome Epidemiology (HuGE) Navigator: SEP15 (11 documents)

    Export disorders for SEP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEP15 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SEP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. (PubMed id 18239845)1, 4, 9 Jablonska E....Wasowicz W. (Eur J Nutr 2008)
    2. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PubMed id 20378690)1, 4, 9 MAcplan C....Hesketh J.E. (Carcinogenesis 2010)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. (PubMed id 20852007)1, 4 Steinbrecher A....Linseisen J. (amp 2010)
    5. A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival. (PubMed id 20424130)1, 4 Penney K.L....Ma J. (Cancer Prev Res (Phila) 2010)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9403 AceView: SEP15 Ensembl:ENSG00000183291 euGenes: HUgn9403

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for SEP15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEP15 gene:
    Search GeneIP for patents involving SEP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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