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Aliases for SEP15 Gene

Aliases for SEP15 Gene

  • 15 KDa Selenoprotein 3 5

External Ids for SEP15 Gene

Previous GeneCards Identifiers for SEP15 Gene

  • GC01M087830
  • GC01M086497
  • GC01M086620
  • GC01M086750
  • GC01M087040
  • GC01M087328

Summaries for SEP15 Gene

Entrez Gene Summary for SEP15 Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEP15 Gene

SEP15 (15 KDa Selenoprotein) is a Protein Coding gene. Among its related pathways are Selenium Pathway. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for SEP15 Gene

  • May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).

Gene Wiki entry for SEP15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEP15 Gene

Genomics for SEP15 Gene

Regulatory Elements for SEP15 Gene

Enhancers for SEP15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEP15 on UCSC Golden Path with GeneCards custom track

Promoters for SEP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEP15 Gene

Chromosome:
1
Start:
86,862,445 bp from pter
End:
86,914,424 bp from pter
Size:
51,980 bases
Orientation:
Minus strand

Genomic View for SEP15 Gene

Genes around SEP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEP15 Gene

Proteins for SEP15 Gene

  • Protein details for SEP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60613-SEP15_HUMAN
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    O60613
    Secondary Accessions:
    • Q4GZG7
    • Q8WU00
    • Q9BS64
    • Q9GZW0
    • Q9NR01

    Protein attributes for SEP15 Gene

    Size:
    162 amino acids
    Molecular mass:
    17790 Da
    Quaternary structure:
    • Forms a tight complex with UGGT1/UGCGL1.
    SequenceCaution:
    • Sequence=AAH05294.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16359.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH21697.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEP15 Gene

Proteomics data for SEP15 Gene at MOPED

Post-translational modifications for SEP15 Gene

Other Protein References for SEP15 Gene

No data available for DME Specific Peptides for SEP15 Gene

Domains & Families for SEP15 Gene

Protein Domains for SEP15 Gene

Graphical View of Domain Structure for InterPro Entry

O60613

UniProtKB/Swiss-Prot:

SEP15_HUMAN :
  • Belongs to the selenoprotein M/SEP15 family.
Family:
  • Belongs to the selenoprotein M/SEP15 family.
genes like me logo Genes that share domains with SEP15: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SEP15 Gene

Function for SEP15 Gene

Molecular function for SEP15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).
genes like me logo Genes that share phenotypes with SEP15: view

Animal Models for SEP15 Gene

MGI Knock Outs for SEP15:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEP15 Gene

Localization for SEP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEP15 Gene

Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for SEP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SEP15: view

No data available for Subcellular locations from COMPARTMENTS for SEP15 Gene

Pathways & Interactions for SEP15 Gene

SuperPathways for SEP15 Gene

Superpath Contained pathways
1 Selenium Pathway
genes like me logo Genes that share pathways with SEP15: view

Pathways by source for SEP15 Gene

1 BioSystems pathway for SEP15 Gene

Gene Ontology (GO) - Biological Process for SEP15 Gene

None

No data available for SIGNOR curated interactions for SEP15 Gene

Drugs & Compounds for SEP15 Gene

(2) Drugs for SEP15 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 168
genes like me logo Genes that share compounds with SEP15: view

Transcripts for SEP15 Gene

Unigene Clusters for SEP15 Gene

15 kDa selenoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEP15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: -

Relevant External Links for SEP15 Gene

GeneLoc Exon Structure for
SEP15

Expression for SEP15 Gene

mRNA expression in normal human tissues for SEP15 Gene

Protein differential expression in normal tissues from HIPED for SEP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Pancreas (8.8), and Monocytes (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEP15 Gene



SOURCE GeneReport for Unigene cluster for SEP15 Gene Hs.362728

mRNA Expression by UniProt/SwissProt for SEP15 Gene

O60613-SEP15_HUMAN
Tissue specificity: Higher levels in prostate and thyroid gland.
genes like me logo Genes that share expression patterns with SEP15: view

Protein tissue co-expression partners for SEP15 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SEP15 Gene

Orthologs for SEP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SEP15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEP15 35
  • 88.48 (n)
  • 93.83 (a)
dog
(Canis familiaris)
Mammalia SEP15 35
  • 89.71 (n)
  • 94.44 (a)
mouse
(Mus musculus)
Mammalia Sep15 35
  • 87.65 (n)
  • 92.59 (a)
Sep15 16
Sep15 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEP15 35
  • 99.39 (n)
  • 100 (a)
SEP15 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sep15 35
  • 86.63 (n)
  • 93.83 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEP15 35
  • 79.29 (n)
  • 87.86 (a)
SEP15 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sep15 35
  • 76.03 (n)
  • 79.45 (a)
zebrafish
(Danio rerio)
Actinopterygii sep15 35
  • 76.03 (n)
  • 86.3 (a)
sep15 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10708 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004986 35
  • 52.48 (n)
  • 50.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7484 35
  • 49.06 (n)
  • 50.7 (a)
CG7484 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y76B12C.3 35
  • 52.68 (n)
  • 41.96 (a)
Y76B12C.3 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05720 35
  • 45.06 (n)
  • 32.41 (a)
rice
(Oryza sativa)
Liliopsida Os01g0894500 35
  • 47.79 (n)
  • 41.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4882 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for SEP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEP15 Gene

ENSEMBL:
Gene Tree for SEP15 (if available)
TreeFam:
Gene Tree for SEP15 (if available)

Paralogs for SEP15 Gene

No data available for Paralogs for SEP15 Gene

Variants for SEP15 Gene

Sequence variations from dbSNP and Humsavar for SEP15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5845 -- 86,863,156(+) ATTTA(A/G)AAATC utr-variant-3-prime
rs5859 -- 86,862,842(+) AATCC(C/T)TAGAA utr-variant-3-prime
rs472653 -- 86,893,300(+) AGAAG(C/T)TGAGA intron-variant
rs473084 -- 86,870,822(+) caccg(C/T)gttag intron-variant
rs473966 -- 86,870,741(+) agcct(A/C)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEP15 Gene

Variant ID Type Subtype PubMed ID
nsv1777 CNV Insertion 18451855
esv1340746 CNV Insertion 17803354

Relevant External Links for SEP15 Gene

HapMap Linkage Disequilibrium report
SEP15
Human Gene Mutation Database (HGMD)
SEP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SEP15 Gene

Disorders for SEP15 Gene

Relevant External Links for SEP15

Genetic Association Database (GAD)
SEP15
Human Genome Epidemiology (HuGE) Navigator
SEP15

No disorders were found for SEP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEP15 Gene

Publications for SEP15 Gene

  1. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. (PMID: 18239845) Jablonska E. … Wasowicz W. (Eur J Nutr 2008) 3 23 48 67
  2. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 23
  3. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. (PMID: 15107826) Apostolou S. … Testa J.R. (Oncogene 2004) 3 23
  4. Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway. (PMID: 25529450) Bang J. … Lee B.J. (Biochem. Biophys. Res. Commun. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SEP15 Gene

Sources for SEP15 Gene

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