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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SENP8 Gene

protein-coding   GIFtS: 53
GCID: GC15P072410

SUMO/Sentrin Specific Peptidase Family Member 8

(Previous names: protease, cysteine, 2 (NEDD8 specific), SUMO/sentrin specific...)
(Previous symbol: PRSC2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SUMO/Sentrin Specific Peptidase Family Member 81 2     Protease, Cysteine, 2 (NEDD8 Specific)1
PRSC21 2 3     SUMO/Sentrin Specific Protease Family Member 81
NEDD8-Specific Protease 11 2 3     deneddylase-12
Sentrin/SUMO-Specific Protease SENP81 3     NEDD8 Specific-Protease Cysteine 22
Deneddylase 11 2     Sentrin-Specific Protease 82
Protease, Cysteine 22 3     SUMO Sentrin Specific Protease Family Member 82
DEN12 3     Deneddylase-13
NEDP12 3     EC 3.4.22.683

External Ids:    HGNC: 229921   Entrez Gene: 1232282   Ensembl: ENSG000001661927   OMIM: 6086595   UniProtKB: Q96LD83   

Export aliases for SENP8 gene to outside databases

Previous GC identifers: GC15P068212 GC15P065515 GC15P070126 GC15P070197 GC15P049236


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SENP8 Gene:
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded
protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell
expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.(provided
by RefSeq, Oct 2009)

GeneCards Summary for SENP8 Gene: 
SENP8 (SUMO/sentrin specific peptidase family member 8) is a protein-coding gene. Diseases associated with SENP8 include dengue disease, and japanese encephalitis. GO annotations related to this gene include cysteine-type peptidase activity.

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to
its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53

Gene Wiki entry for SENP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SENP8 gene promoter:
         Sp1   SREBP-1c   HNF-1A   SREBP-1b   CREB   SREBP-1a   deltaCREB   HNF-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SENP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.33

SENP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P072410:  view genomic region     (about GC identifiers)

Start:
72,406,599 bp from pter      End:
72,433,311 bp from pter
Size:
26,713 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8 (See protein sequence)
Recommended Name: Sentrin-specific protease 8  
Size: 212 amino acids; 24107 Da
3 PDB 3D structures from and Proteopedia for SENP8:
1XT9 (3D)        2BKQ (3D)        2BKR (3D)    
Secondary accessions: Q96QA4

Explore the universe of human proteins at neXtProt for SENP8: NX_Q96LD8

Explore proteomics data for SENP8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LD8

  • SENP8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SENP8 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001159812.1  NP_001165580.1  NP_001165581.1  NP_001165582.1  NP_660205.3  

    ENSEMBL proteins: 
     ENSP00000446057   ENSP00000457208   ENSP00000456567   ENSP00000340505   ENSP00000457215  
     ENSP00000441753   ENSP00000439415  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q96LD8

    ProtoNet protein and cluster: Q96LD8

    UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
    Similarity: Belongs to the peptidase C48 family


    SENP8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP8_HUMAN, Q96LD8
    Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to
    its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein
    Biophysicochemical properties: Kinetic parameters: KM=51 nM for Nedd8-AMC; Note=KM for Ub-AMC exceeds 5uM;

         Enzyme Number (IUBMB): EC 3.4.22.681

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008234cysteine-type peptidase activity IEA--
         
    SENP8 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SENP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SENP8 (Q96LD82, 3 ENSP000003405054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629132, 3, ENSP000003636764MINT-6541125 I2D: score=1 STRING: ENSP00000363676
    AKIP1Q9NQ313, ENSP000003104594I2D: score=1 STRING: ENSP00000310459
    NEDD8Q158433, ENSP000002504954I2D: score=6 STRING: ENSP00000250495
    UBBENSP000003046974STRING: ENSP00000304697
    PLA2G2AENSP000003642524STRING: ENSP00000364252
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    SENP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SENP8

    Search CenterWatch for drugs/clinical trials and news about SENP8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SENP8 gene (5 alternative transcripts): 
    NM_001166340.1  NM_001172109.1  NM_001172110.1  NM_001172111.1  NM_145204.3  

    Unigene Cluster for SENP8:

    SUMO/sentrin specific peptidase family member 8
    Hs.513002  [show with all ESTs]
    Unigene Representative Sequence: NM_001172109
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542035(uc021spq.1) ENST00000567794 ENST00000564863 ENST00000340912
    ENST00000564082 ENST00000544411(uc021spr.1 uc021sps.1) ENST00000544171(uc021spt.1 uc002atp.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SENP8:
    hsa-miR-1179 hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSENP8 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF308450.1 AK097557.1 AK292298.1 AY008293.1 BC031411.1 

    5 DOTS entries:

    DT.95261419  DT.97799296  DT.102821750  DT.121077461  DT.121077504 

    15 AceView cDNA sequences:

    BP370384 CD245518 NM_145204 CR595304 BC031411 BI758706 AK097557 AL542781 
    BP376639 BX390779 BG699423 CD689529 AL569616 BI548939 BI769620 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SENP8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                    -     -                                 
    SP2:              -     -     -                                 
    SP3:                                                            
    SP4:                                -                           


    ECgene alternative splicing isoforms for SENP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SENP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGGCTTT
    SENP8 Expression
    About this image


    See SENP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SENP8

    SOURCE GeneReport for Unigene cluster: Hs.513002

    UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
    Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SENP8 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp81 , 5 SUMO/sentrin specific peptidase 81, 5 90.25(n)1
    92.45(a)1
      9 (32.11 cM)5
    715991  NM_001172071.11  NP_001165542.11 
     597342595 
    chicken
    (Gallus gallus)
    Aves SENP81 SUMO/sentrin specific peptidase family member 8 75(n)
    76.42(a)
      415322  XM_413710.3  XP_413710.1 
    lizard
    (Anolis carolinensis)
    Reptilia SENP86
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343479.1(396865-397642)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420032952   -- 77.23(n)    142003295 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.195982 Transcribed sequence with weak similarity to protein more 77.23(n)    BI868113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Den11 Deneddylase 1 48.47(n)
    37.2(a)
      36339  NM_001169655.1  NP_001163126.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ulp-36
    Protein ULP-3
    27(a)
    1 ↔ 1
    IV(1963191-1964717)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G601901 NEDD8-specific protease 1 46.05(n)
    37.57(a)
      836141  NM_125412.3  NP_200827.1 


    ENSEMBL Gene Tree for SENP8 (if available)
    TreeFam Gene Tree for SENP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/363 SNPs in SENP8 are shown (see all 363)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425515431,2
    --72412647(+) GACCAA/CGACAG 5 -- int10--------
    rs1178289021,2
    C,F--72412669(+) TATCTA/GTTAAC 5 -- int11Minor allele frequency- G:0.01NA 120
    rs1882674411,2
    --72412709(+) ACCCAA/GATAAG 5 -- int10--------
    rs1808311311,2
    --72412859(+) GAAGTA/GATTAA 5 -- int10--------
    rs1865129301,2
    --72413206(+) GTGGTA/CCACAC 5 -- int10--------
    rs561035401,2
    C--72413258(+) ACAAAG/CATGCA 5 -- int15Minor allele frequency- C:0.31NA CSA WA EA 362
    rs1912653811,2
    --72413493(+) AACCAA/GGGCCT 5 -- int10--------
    rs1398079821,2
    --72413576(+) TGGGGC/TTATTT 5 -- int10--------
    rs1817422181,2
    --72413679(+) TTAGAA/GTTCTG 5 -- int10--------
    rs1439106431,2
    --72413877(+) CCAGCC/GTGGGC 5 -- int10--------

    HapMap Linkage Disequilibrium report for SENP8 (72406599 - 72433311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SENP8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675300CNV Deletion23128226
    nsv511557CNV Loss21212237
    nsv510665CNV Loss20534489
    nsv833051CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608659    OMIM disorders: --

    6 diseases for SENP8:    About MalaCards
    dengue disease    japanese encephalitis    yellow fever    encephalitis
    prostatitis    breast cancer


    SENP8 for disorders           About GeneDecksing


    Export disorders for SENP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SENP8 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SENP8)
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    1. Identification and characterization of DEN1, a deneddylase of the ULP family. (PubMed id 12759362)1, 2, 3, 9 Gan-Erdene T....Wilkinson K.D. (2003)
    2. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PubMed id 12730221)1, 2, 3 Mendoza H.M....Hay R.T. (2003)
    3. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PubMed id 12759363)1, 2, 9 Wu K.... Pan Z.-Q. (2003)
    4. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PubMed id 15567417)1, 2, 9 Reverter D.... Lima C.D. (2005)
    5. Structural basis of NEDD8 ubiquitin discrimination by the deneddylating enzyme NEDP1. (PubMed id 15775960)1, 2 Shen L.-N.... Hay R.T. (2005)
    6. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PubMed id 15242646)1, 2 Xirodimas D.P.... Lane D.P. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. (PubMed id 19328766)1, 9 Engels I.H....Brinker A. (2009)
    9. Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. (PubMed id 23408908)1 Christmann M....Braus G.H. (2013)
    10. Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. (PubMed id 23209320)1 Ehrentraut S.F....Colgan S.P. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 123228 HGNC: 22992 AceView: SENP8 Ensembl:ENSG00000166192 euGenes: HUgn123228
    ECgene: SENP8 H-InvDB: SENP8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SENP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SENP8 gene:
    Search GeneIP for patents involving SENP8

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