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Aliases for SENP8 Gene

Aliases for SENP8 Gene

  • SUMO/Sentrin Specific Peptidase Family Member 8 2 3
  • NEDD8-Specific Protease 1 2 3 4
  • NEDP1 3 4 6
  • DEN1 3 4 6
  • Sentrin/SUMO-Specific Protease SENP8 2 4
  • Protease, Cysteine 2 3 4
  • Deneddylase 1 2 3
  • Deneddylase-1 3 4
  • PRSC2 3 4
  • SUMO/Sentrin Specific Protease Family Member 8 2
  • SUMO Sentrin Specific Protease Family Member 8 3
  • Protease, Cysteine, 2 (NEDD8 Specific) 2
  • NEDD8 Specific-Protease Cysteine 2 3
  • Sentrin-Specific Protease 8 3
  • EC 4

External Ids for SENP8 Gene

Previous Symbols for SENP8 Gene

  • PRSC2

Summaries for SENP8 Gene

Entrez Gene Summary for SENP8 Gene

  • This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SENP8 Gene

SENP8 (SUMO/Sentrin Specific Peptidase Family Member 8) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity.

UniProtKB/Swiss-Prot for SENP8 Gene

  • Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Gene Wiki entry for SENP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP8 Gene

Genomics for SENP8 Gene

Genomic Location for SENP8 Gene

72,114,258 bp from pter
72,143,688 bp from pter
29,431 bases
Plus strand

Genomic View for SENP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP8 Gene

Regulatory Elements for SENP8 Gene

Proteins for SENP8 Gene

  • Protein details for SENP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sentrin-specific protease 8
    Protein Accession:
    Secondary Accessions:
    • Q96QA4

    Protein attributes for SENP8 Gene

    212 amino acids
    Molecular mass:
    24107 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP8 Gene

neXtProt entry for SENP8 Gene

Proteomics data for SENP8 Gene at MOPED

Post-translational modifications for SENP8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SENP8 Gene

Domains for SENP8 Gene

Protein Domains for SENP8 Gene



  • Belongs to the peptidase C48 family.:
    • Q96LD8
genes like me logo Genes that share domains with SENP8: view

No data available for Gene Families for SENP8 Gene

Function for SENP8 Gene

Molecular function for SENP8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=51 nM for Nedd8-AMC {ECO:0000269 PubMed:12759362}; Note=KM for Ub-AMC exceeds 5uM.;
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Enzyme Numbers (IUBMB) for SENP8 Gene

Gene Ontology (GO) - Molecular Function for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity --
GO:0019784 NEDD8-specific protease activity IBA --
genes like me logo Genes that share ontologies with SENP8: view

miRNA for SENP8 Gene

miRTarBase miRNAs that target SENP8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SENP8 Gene

Localization for SENP8 Gene

Subcellular locations from

Jensen Localization Image for SENP8 Gene COMPARTMENTS Subcellular localization image for SENP8 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SENP8: view

Pathways for SENP8 Gene

SuperPathways for SENP8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IBA --
GO:0006508 proteolysis --
genes like me logo Genes that share ontologies with SENP8: view

No data available for Pathways by source for SENP8 Gene

Transcripts for SENP8 Gene

mRNA/cDNA for SENP8 Gene

Unigene Clusters for SENP8 Gene

SUMO/sentrin specific peptidase family member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - - -
SP4: -

Relevant External Links for SENP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SENP8 Gene

mRNA expression in normal human tissues for SENP8 Gene

mRNA differential expression in normal tissues according to GTEx for SENP8 Gene

This gene is overexpressed in Testis (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SENP8 Gene

SOURCE GeneReport for Unigene cluster for SENP8 Gene Hs.513002

mRNA Expression by UniProt/SwissProt for SENP8 Gene

Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas.
genes like me logo Genes that share expressions with SENP8: view

Orthologs for SENP8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SENP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SENP8 36
  • 99.37 (n)
  • 99.06 (a)
SENP8 37
  • 99 (a)
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
-- 37
  • 84 (a)
(Canis familiaris)
Mammalia SENP8 36
  • 92.89 (n)
  • 95.73 (a)
SENP8 37
  • 95 (a)
(Mus musculus)
Mammalia Senp8 36
  • 90.25 (n)
  • 92.45 (a)
Senp8 16
Senp8 37
  • 84 (a)
(Monodelphis domestica)
Mammalia SENP8 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SENP8 37
  • 80 (a)
(Rattus norvegicus)
Mammalia Senp8 36
  • 89.62 (n)
  • 92.45 (a)
(Gallus gallus)
Aves SENP8 36
  • 75 (n)
  • 76.42 (a)
SENP8 37
  • 72 (a)
(Anolis carolinensis)
Reptilia SENP8 37
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia senp8 36
  • 58.13 (n)
  • 51.21 (a)
(Danio rerio)
Actinopterygii Dr.19598 36
senp8 36
  • 60.82 (n)
  • 63.03 (a)
senp8 37
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011316 36
  • 47.1 (n)
  • 41.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Den1 36
  • 48.31 (n)
  • 37.2 (a)
Den1 37
  • 31 (a)
(Caenorhabditis elegans)
Secernentea ulp-3 37
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60190 36
  • 46.44 (n)
  • 36.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
Species with no ortholog for SENP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP8 Gene

Gene Tree for SENP8 (if available)
Gene Tree for SENP8 (if available)

Paralogs for SENP8 Gene

No data available for Paralogs for SENP8 Gene

Variants for SENP8 Gene

Sequence variations from dbSNP and Humsavar for SENP8 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13858 -- 72,140,803(+) GTGAC(A/G)TCTCT utr-variant-3-prime
rs930871 - 72,140,242(+) TCATT(A/G)CCACA reference, missense
rs2034879 -- 72,137,648(+) GGAAG(A/G)AGGAA intron-variant
rs2034880 -- 72,137,888(+) aatgg(C/T)gtgaa intron-variant
rs2415133 -- 72,125,716(+) TTTTT(A/G)TCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP8 Gene

Variant ID Type Subtype PubMed ID
nsv833051 CNV Gain 17160897
nsv510665 CNV Loss 20534489
nsv511557 CNV Loss 21212237
esv2675300 CNV Deletion 23128226

Relevant External Links for SENP8 Gene

HapMap Linkage Disequilibrium report

Disorders for SENP8 Gene

No disorders were found for SENP8 Gene.

No data available for UniProtKB/Swiss-Prot for SENP8 Gene

Publications for SENP8 Gene

  1. Identification and characterization of DEN1, a deneddylase of the ULP family. (PMID: 12759362) Gan-Erdene T. … Wilkinson K.D. (J. Biol. Chem. 2003) 2 3 4 23
  2. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PMID: 12759363) Wu K. … Pan Z.-Q. (J. Biol. Chem. 2003) 3 4 23
  3. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PMID: 15567417) Reverter D. … Lima C.D. (J. Mol. Biol. 2005) 3 4 23
  4. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PMID: 12730221) Mendoza H.M. … Hay R.T. (J. Biol. Chem. 2003) 2 3 4
  5. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PMID: 15242646) Xirodimas D.P. … Lane D.P. (Cell 2004) 3 4

Products for SENP8 Gene

  • Addgene plasmids for SENP8

Sources for SENP8 Gene

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