Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SENP8 Gene

protein-coding   GIFtS: 52
GCID: GC15P072410

SUMO/Sentrin Specific Peptidase Family Member 8

(Previous names: protease, cysteine, 2 (NEDD8 specific), SUMO/sentrin specific...)
(Previous symbol: PRSC2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SUMO/Sentrin Specific Peptidase Family Member 81 2     Protease, Cysteine, 2 (NEDD8 Specific)1
PRSC21 2 3     SUMO/Sentrin Specific Protease Family Member 81
NEDD8-Specific Protease 11 2 3     deneddylase-12
DEN12 3 5     NEDD8 Specific-Protease Cysteine 22
NEDP12 3 5     Sentrin-Specific Protease 82
Sentrin/SUMO-Specific Protease SENP81 3     SUMO Sentrin Specific Protease Family Member 82
Deneddylase 11 2     Deneddylase-13
Protease, Cysteine 22 3     EC 3.4.22.683

External Ids:    HGNC: 229921   Entrez Gene: 1232282   Ensembl: ENSG000001661927   OMIM: 6086595   UniProtKB: Q96LD83   

Export aliases for SENP8 gene to outside databases

Previous GC identifers: GC15P068212 GC15P065515 GC15P070126 GC15P070197 GC15P049236


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SENP8 Gene:
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded
protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell
expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.(provided
by RefSeq, Oct 2009)

GeneCards Summary for SENP8 Gene:
SENP8 (SUMO/sentrin specific peptidase family member 8) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity.

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to
its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53

Gene Wiki entry for SENP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP8 gene promoter:
         Sp1   SREBP-1c   HNF-1A   SREBP-1b   CREB   SREBP-1a   deltaCREB   HNF-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP8 promoter sequence
   Search Chromatin IP Primers for SENP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.33

SENP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P072410:  view genomic region     (about GC identifiers)

Start:
72,406,599 bp from pter      End:
72,433,311 bp from pter
Size:
26,713 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8 (See protein sequence)
Recommended Name: Sentrin-specific protease 8  
Size: 212 amino acids; 24107 Da
3 PDB 3D structures from and Proteopedia for SENP8:
1XT9 (3D)        2BKQ (3D)        2BKR (3D)    
Secondary accessions: Q96QA4

Explore the universe of human proteins at neXtProt for SENP8: NX_Q96LD8

Explore proteomics data for SENP8 at MOPED


See SENP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001159812.1  NP_001165580.1  NP_001165581.1  NP_001165582.1  NP_660205.3  

ENSEMBL proteins: 
 ENSP00000446057   ENSP00000457208   ENSP00000456567   ENSP00000340505   ENSP00000457215  
 ENSP00000441753   ENSP00000439415  

SENP8 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for SENP8 (NEDP1/SENP8)
Enzo Life Sciences proteins for SENP8
OriGene Purified Proteins for SENP8
OriGene Protein Over-expression Lysate for SENP8
OriGene MassSpec for SENP8
OriGene Custom Protein Services for SENP8
GenScript Custom Purified and Recombinant Proteins Services for SENP8
Novus Biologicals SENP8 Proteins
Novus Biologicals SENP8 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for SENP8
Cloud-Clone Corp. Proteins for SENP8

 
Search eBioscience for Proteins for SENP8 

 
antibodies-online proteins for SENP8 (14 products) 

 
antibodies-online peptides for SENP8

SENP8 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for SENP8 (NEDP1/SENP8)
OriGene Antibodies for SENP8
OriGene Custom Antibody Services for SENP8
Novus Biologicals SENP8 Antibodies
Abcam antibodies for SENP8
Cloud-Clone Corp. Antibodies for SENP8
ThermoFisher Antibodies for SENP8
antibodies-online antibodies for SENP8 (39 products) 

SENP8 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SENP8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SENP8
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SENP8
Cloud-Clone Corp. CLIAs for SENP8
Search eBioscience for ELISAs for SENP8 
antibodies-online kits for SENP8 (7 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
1 InterPro protein domain:
 IPR003653 Peptidase_C48

Graphical View of Domain Structure for InterPro Entry Q96LD8

ProtoNet protein and cluster: Q96LD8

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
Similarity: Belongs to the peptidase C48 family


Find genes that share domains with SENP8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SENP8_HUMAN, Q96LD8
Function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to
its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53
Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
of the mature SUMO and the lysine epsilon-amino group of the target protein
Biophysicochemical properties: Kinetic parameters: KM=51 nM for Nedd8-AMC; Note=KM for Ub-AMC exceeds 5uM;

     Enzyme Number (IUBMB): EC 3.4.22.681

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008234cysteine-type peptidase activity IEA--
     
Find genes that share ontologies with SENP8           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for SENP8

miRNA
Products:
    
miRTarBase miRNAs that target SENP8:
hsa-mir-124-3p (MIRT002912)

Block miRNA regulation of human, mouse, rat SENP8 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate SENP8:
hsa-miR-1179 hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidSENP8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SENP8
Predesigned siRNA for gene silencing in human, mouse, rat SENP8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SENP8

Clone
Products:
     
OriGene clones in human, mouse for SENP8 (see all 27)
OriGene ORF clones in mouse, rat for SENP8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): SENP8 (NM_145204)
Sino Biological Human cDNA Clone for SENP8
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP8
Addgene plasmids for SENP8 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SENP8
Browse ESI BIO Cell Lines and PureStem Progenitors for SENP8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus




    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP8
Interactions:

    GeneGlobe Interaction Network for SENP8

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for SENP8 (Q96LD82, 3 ENSP000003405054) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
RPL11P629132, 3, ENSP000003636764MINT-6541125 I2D: score=1 STRING: ENSP00000363676
AKIP1Q9NQ313, ENSP000003104594I2D: score=1 STRING: ENSP00000310459
NEDD8Q158433, ENSP000002504954I2D: score=6 STRING: ENSP00000250495
UBBENSP000003046974STRING: ENSP00000304697
MAD2L1ENSP000002965094STRING: ENSP00000296509
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----

Find genes that share ontologies with SENP8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SENP8



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SENP8 gene (5 alternative transcripts): 
NM_001166340.1  NM_001172109.1  NM_001172110.1  NM_001172111.1  NM_145204.3  

Unigene Cluster for SENP8:

SUMO/sentrin specific peptidase family member 8
Hs.513002  [show with all ESTs]
Unigene Representative Sequence: NM_001172109
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000542035(uc021spq.1) ENST00000567794 ENST00000564863 ENST00000340912
ENST00000564082 ENST00000544411(uc021spr.1 uc021sps.1) ENST00000544171(uc021spt.1 uc002atp.3)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SENP8 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate SENP8:
hsa-miR-1179 hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidSENP8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SENP8
Predesigned siRNA for gene silencing in human, mouse, rat SENP8
Clone
Products:
     
OriGene clones in human, mouse for SENP8 (see all 27)
OriGene ORF clones in mouse, rat for SENP8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): SENP8 (NM_145204)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP8
Addgene plasmids for SENP8 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SENP8
OriGene qSTAR qPCR primer pairs in human, mouse for SENP8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP8
  QuantiTect SYBR Green Assays in human, mouse, rat SENP8
  QuantiFast Probe-based Assays in human, mouse, rat SENP8

Additional mRNA sequence: 

AF308450.1 AK097557.1 AK292298.1 AY008293.1 BC031411.1 

5 DOTS entries:

DT.95261419  DT.97799296  DT.102821750  DT.121077461  DT.121077504 

15 AceView cDNA sequences:

CR595304 BP370384 BC031411 CD245518 NM_145204 BI758706 BP376639 AL542781 
AK097557 BX390779 BG699423 CD689529 BI548939 AL569616 BI769620 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SENP8    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:                    -     -                                 
SP2:              -     -     -                                 
SP3:                                                            
SP4:                                -                           


ECgene alternative splicing isoforms for SENP8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SENP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CACAGGCTTT
SENP8 Expression
About this image

SENP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SENP8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513002

UniProtKB/Swiss-Prot: SENP8_HUMAN, Q96LD8
Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas

    Custom PCR Arrays for SENP8
Primer
Products:
OriGene qPCR primer pairs and template standards for SENP8
OriGene qSTAR qPCR primer pairs in human, mouse for SENP8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP8
QuantiTect SYBR Green Assays in human, mouse, rat SENP8
QuantiFast Probe-based Assays in human, mouse, rat SENP8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for SENP8 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Senp81 , 5 SUMO/sentrin specific peptidase 81, 5 90.25(n)1
92.45(a)1
  9 (32.11 cM)5
715991  NM_001172071.11  NP_001165542.11 
 597342595 
chicken
(Gallus gallus)
Aves SENP81 SUMO/sentrin specific peptidase family member 8 75(n)
76.42(a)
  415322  XM_413710.4  XP_413710.1 
lizard
(Anolis carolinensis)
Reptilia SENP86
SUMO/sentrin specific peptidase family member 8
71(a)
1 ↔ 1
GL343479.1(396865-397642)
tropical clawed frog
(Xenopus tropicalis)
Amphibia 1420032952   -- 77.23(n)    142003295 
zebrafish
(Danio rerio)
Actinopterygii Dr.195982 Transcribed sequence with weak similarity to protein more 77.23(n)    BI868113.1 
fruit fly
(Drosophila melanogaster)
Insecta Den11 Deneddylase 1 48.31(n)
37.2(a)
  36339  NM_136919.2  NP_610763.1 
worm
(Caenorhabditis elegans)
Secernentea ulp-36
Protein ULP-3 (ulp-3) mRNA, complete cds
27(a)
1 ↔ 1
IV(1963191-1964717) WBGene00006738
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G601901 AT5G60190 46.44(n)
36.42(a)
  836141  NM_125412.3  NP_200827.1 


ENSEMBL Gene Tree for SENP8 (if available)
TreeFam Gene Tree for SENP8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SENP8 (see all 363)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1425515431,2
--72412647(+) GACCAA/CGACAG 5 -- int10--------
rs1178289021,2
C,F--72412669(+) TATCTA/GTTAAC 5 -- int11Minor allele frequency- G:0.01NA 120
rs1882674411,2
--72412709(+) ACCCAA/GATAAG 5 -- int10--------
rs1808311311,2
--72412859(+) GAAGTA/GATTAA 5 -- int10--------
rs1865129301,2
--72413206(+) GTGGTA/CCACAC 5 -- int10--------
rs561035401,2
C--72413258(+) ACAAAG/CATGCA 5 -- int15Minor allele frequency- C:0.31NA CSA WA EA 362
rs1912653811,2
--72413493(+) AACCAA/GGGCCT 5 -- int10--------
rs1398079821,2
--72413576(+) TGGGGC/TTATTT 5 -- int10--------
rs1817422181,2
--72413679(+) TTAGAA/GTTCTG 5 -- int10--------
rs1439106431,2
--72413877(+) CCAGCC/GTGGGC 5 -- int10--------

HapMap Linkage Disequilibrium report for SENP8 (72406599 - 72433311 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SENP8:    About this table    
Variant IDTypeSubtypePubMed ID
esv2675300CNV Deletion23128226
nsv511557CNV Loss21212237
nsv510665CNV Loss20534489
nsv833051CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SENP8
DNA2.0 Custom Variant and Variant Library Synthesis for SENP8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 608659    OMIM disorders: --


Find genes that share disorders with SENP8           About GenesLikeMe


Export disorders for SENP8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SENP8 gene, integrated from 10 sources (see all 38):
(articles sorted by number of sources associating them with SENP8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of DEN1, a deneddylase of the ULP family. (PubMed id 12759362)1, 2, 3, 9 Gan-Erdene T....Wilkinson K.D. (J. Biol. Chem. 2003)
  2. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PubMed id 12730221)1, 2, 3 Mendoza H.M....Hay R.T. (J. Biol. Chem. 2003)
  3. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PubMed id 12759363)1, 2, 9 Wu K.... Pan Z.-Q. (J. Biol. Chem. 2003)
  4. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PubMed id 15567417)1, 2, 9 Reverter D.... Lima C.D. (J. Mol. Biol. 2005)
  5. Structural basis of NEDD8 ubiquitin discrimination by the deneddylating enzyme NEDP1. (PubMed id 15775960)1, 2 Shen L.-N.... Hay R.T. (EMBO J. 2005)
  6. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PubMed id 15242646)1, 2 Xirodimas D.P.... Lane D.P. (Cell 2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. (PubMed id 19328766)1, 9 Engels I.H....Brinker A. (Anal. Biochem. 2009)
  9. Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. (PubMed id 23408908)1 Christmann M....Braus G.H. (PLoS Genet. 2013)
  10. NEDDylation controls the target specificity of E2F1 and apoptosis induction. (PubMed id 23001041)1 Aoki I....Gotoh Y. (Oncogene 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 123228 HGNC: 22992 AceView: SENP8 Ensembl:ENSG00000166192 euGenes: HUgn123228
ECgene: SENP8 H-InvDB: SENP8

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SENP8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SENP8 gene:
Search GeneIP for patents involving SENP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for SENP8 (NEDP1/SENP8)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for SENP8 (NEDP1/SENP8)   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for SENP8   OriGene RNAi products in human, mouse, rat for SENP8  
 OriGene qPCR primer pairs and template standards for SENP8   OriGene Protein Over-expression Lysate for SENP8  
 OriGene MassSpec for SENP8   OriGene clones in human, mouse for SENP8  
 OriGene qSTAR qPCR primer pairs in human, mouse for SENP8   OriGene Purified Protein for SENP8  
 OriGene ORF clones in mouse, rat for SENP8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SENP8   OriGene Custom Protein Services for SENP8  

 
 
 Block miRNA regulation of human, mouse, rat SENP8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SENP8
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP8 Predesigned siRNA for gene silencing in human, mouse, rat SENP8
 QuantiFast Probe-based Assays in human, mouse, rat SENP8 QuantiTect SYBR Green Assays in human, mouse, rat SENP8
 Custom PCR Arrays for SENP8 Search Chromatin IP Primers for SENP8
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP8  GeneGlobe Interaction Network for SENP8
 Regulatory tfbs in SENP8 promoter
 GenScript Custom Purified and Recombinant Proteins Services for SENP8 GenScript cDNA clones with any tag delivered in your preferred vector for SENP8
 GenScript Custom Assay Services for SENP8 GenScript Custom overexpressing Cell Line Services for SENP8
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SENP8
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for SENP8
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Proteins for SENP8
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SENP8 antibodies
 SENP8 proteins
 SENP8 lysates
 Antibodies for SENP8
 See all of Abcam's Antibodies, Kits and Proteins for SENP8
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for SENP8
 Proteins for SENP8
 Antibodies for SENP8
 ELISAs for SENP8
 CLIAs for SENP8



 Browse ESI BIO Cell Lines and PureStem Progenitors for SENP8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP8
 SwitchGear 3'UTR luciferase reporter plasmids for SENP8
 SwitchGear Promoter luciferase reporter plasmids for SENP8
 ThermoFisher Antibodies for SENP8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP8
 Browse compounds at ApexBio
 Addgene plasmids for SENP8
  Search eBioscience for proteins for SENP8
  Search eBioscience for elisas for SENP8
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for SENP8
 antibodies-online antibodies for SENP8 (39 products)
 antibodies-online kits for SENP8 (7 products)
 antibodies-online peptides for SENP8
 antibodies-online proteins for SENP8 (14 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SENP8 gene at Home site.
Version: 3.12.248 16 Nov 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4