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Aliases for SENP8 Gene

Aliases for SENP8 Gene

  • SUMO/Sentrin Peptidase Family Member, NEDD8 Specific 2 3 5
  • NEDD8-Specific Protease 1 2 3 4
  • SUMO/Sentrin Specific Peptidase Family Member 8 2 3
  • Sentrin/SUMO-Specific Protease SENP8 2 4
  • Protease, Cysteine 2 3 4
  • Deneddylase 1 2 3
  • PRSC2 3 4
  • NEDP1 3 4
  • DEN1 3 4
  • SUMO/Sentrin Specific Protease Family Member 8 2
  • SUMO Sentrin Specific Protease Family Member 8 3
  • Protease, Cysteine, 2 (NEDD8 Specific) 2
  • NEDD8 Specific-Protease Cysteine 2 3
  • Sentrin-Specific Protease 8 3
  • Deneddylase-1 4
  • EC 3.4.22.68 4

External Ids for SENP8 Gene

Previous HGNC Symbols for SENP8 Gene

  • PRSC2

Previous GeneCards Identifiers for SENP8 Gene

  • GC15P068212
  • GC15P065515
  • GC15P070126
  • GC15P070197
  • GC15P072410
  • GC15P049236

Summaries for SENP8 Gene

Entrez Gene Summary for SENP8 Gene

  • This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for SENP8 Gene

SENP8 (SUMO/Sentrin Peptidase Family Member, NEDD8 Specific) is a Protein Coding gene. Diseases associated with SENP8 include Dengue Disease and Exanthem. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include cysteine-type peptidase activity and NEDD8-specific protease activity.

UniProtKB/Swiss-Prot for SENP8 Gene

  • Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Gene Wiki entry for SENP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP8 Gene

Genomics for SENP8 Gene

Regulatory Elements for SENP8 Gene

Enhancers for SENP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072604 0.8 FANTOM5 ENCODE 30.6 +490.7 490744 0.2 TCF7L2 TMEM202 SENP8 MIR630 HEXA MYO9A ENSG00000278313 LOC100420930
GH15F072154 0.7 FANTOM5 ENCODE 18.8 +41.6 41567 1.9 PKNOX1 WRNIP1 SIN3A GLI4 ZNF48 ZNF2 ZNF121 GLIS2 ELK1 ZNF143 SENP8 MYO9A ENSG00000261187 BBS4 TMEM202 CELF6 ENSG00000260173 GRAMD2
GH15F072090 0.3 FANTOM5 14.8 -23.1 -23092 0.4 SENP8 MYO9A CELF6 RNU2-65P
GH15F072161 0.2 ENCODE 12 +47.3 47337 0.2 NR2F6 ZIC2 MYO9A SENP8 ENSG00000260173 GRAMD2
GH15F072162 0.9 ENCODE 12 +48.0 48046 1.2 ZNF121 GLIS2 NR2F6 MYO9A SENP8 NR2E3 ENSG00000260173 GRAMD2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SENP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SENP8 Gene

Chromosome:
15
Start:
72,114,258 bp from pter
End:
72,143,688 bp from pter
Size:
29,431 bases
Orientation:
Plus strand

Genomic View for SENP8 Gene

Genes around SENP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP8 Gene

Proteins for SENP8 Gene

  • Protein details for SENP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LD8-SENP8_HUMAN
    Recommended name:
    Sentrin-specific protease 8
    Protein Accession:
    Q96LD8
    Secondary Accessions:
    • Q96QA4

    Protein attributes for SENP8 Gene

    Size:
    212 amino acids
    Molecular mass:
    24107 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP8 Gene

neXtProt entry for SENP8 Gene

Post-translational modifications for SENP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SENP8
  • Santa Cruz Biotechnology (SCBT) Antibodies for SENP8

No data available for DME Specific Peptides for SENP8 Gene

Domains & Families for SENP8 Gene

Gene Families for SENP8 Gene

Protein Domains for SENP8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SENP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LD8

UniProtKB/Swiss-Prot:

SENP8_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP8: view

Function for SENP8 Gene

Molecular function for SENP8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=51 nM for Nedd8-AMC {ECO:0000269 PubMed:12759362}; Note=KM for Ub-AMC exceeds 5 uM.;
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

Enzyme Numbers (IUBMB) for SENP8 Gene

Gene Ontology (GO) - Molecular Function for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SENP8: view

Phenotypes for SENP8 Gene

GenomeRNAi human phenotypes for SENP8:
genes like me logo Genes that share phenotypes with SENP8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SENP8

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP8 Gene

Localization for SENP8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP8 Gene COMPARTMENTS Subcellular localization image for SENP8 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SENP8 Gene

Pathways & Interactions for SENP8 Gene

genes like me logo Genes that share pathways with SENP8: view

Pathways by source for SENP8 Gene

1 GeneTex pathway for SENP8 Gene

Gene Ontology (GO) - Biological Process for SENP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SENP8: view

No data available for SIGNOR curated interactions for SENP8 Gene

Drugs & Compounds for SENP8 Gene

(2) Drugs for SENP8 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor, Broad spectrum DUB inhibitor 0
ST074946 Pharma 0

(1) ApexBio Compounds for SENP8 Gene

Compound Action Cas Number
PR-619 Deubiquitylating enzymes (DBUs) inhibitor 2645-32-1
genes like me logo Genes that share compounds with SENP8: view

Transcripts for SENP8 Gene

Unigene Clusters for SENP8 Gene

SUMO/sentrin specific peptidase family member 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SENP8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SENP8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for SENP8 Gene

GeneLoc Exon Structure for
SENP8
ECgene alternative splicing isoforms for
SENP8

Expression for SENP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP8 Gene

mRNA differential expression in normal tissues according to GTEx for SENP8 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for SENP8 Gene

This gene is overexpressed in Adipocyte (15.8), Bone (11.4), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SENP8 Gene



NURSA nuclear receptor signaling pathways regulating expression of SENP8 Gene:

SENP8

SOURCE GeneReport for Unigene cluster for SENP8 Gene:

Hs.513002

mRNA Expression by UniProt/SwissProt for SENP8 Gene:

Q96LD8-SENP8_HUMAN
Tissue specificity: Broadly expressed, with highest levels in kidney and pancreas.
genes like me logo Genes that share expression patterns with SENP8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SENP8 Gene

Orthologs for SENP8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SENP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP8 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia SENP8 34 35
  • 92.89 (n)
mouse
(Mus musculus)
Mammalia Senp8 34 16 35
  • 90.25 (n)
rat
(Rattus norvegicus)
Mammalia Senp8 34
  • 89.62 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SENP8 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SENP8 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP8 34 35
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia SENP8 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia senp8 34
  • 58.13 (n)
zebrafish
(Danio rerio)
Actinopterygii senp8 34 35
  • 60.82 (n)
Dr.19598 34
fruit fly
(Drosophila melanogaster)
Insecta Den1 34 35
  • 48.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011316 34
  • 47.1 (n)
worm
(Caenorhabditis elegans)
Secernentea ulp-3 35
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60190 34
  • 46.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for SENP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP8 Gene

ENSEMBL:
Gene Tree for SENP8 (if available)
TreeFam:
Gene Tree for SENP8 (if available)

Paralogs for SENP8 Gene

No data available for Paralogs for SENP8 Gene

Variants for SENP8 Gene

Sequence variations from dbSNP and Humsavar for SENP8 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11072347 -- 72,126,630(+) AAAAA(A/T)TAGGA intron-variant
rs111401533 -- 72,133,817(+) ACCCC(C/G)TGACA intron-variant
rs111446198 -- 72,130,150(+) GCGCC(A/G)TTGCA intron-variant
rs111536682 -- 72,134,363(+) TAACT(G/T)GAGCT intron-variant
rs111627506 -- 72,144,041(+) CAGAT(C/T)ACGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SENP8 Gene

Variant ID Type Subtype PubMed ID
esv2675300 CNV deletion 23128226
nsv510665 CNV deletion 20534489
nsv511557 CNV loss 21212237
nsv833051 CNV gain 17160897
nsv976948 CNV duplication 23825009

Variation tolerance for SENP8 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SENP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP8 Gene

Disorders for SENP8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SENP8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dengue disease
  • breakbone fever
exanthem
  • exanthema
- elite association - COSMIC cancer census association via MalaCards
Search SENP8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP8
genes like me logo Genes that share disorders with SENP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP8 Gene

Publications for SENP8 Gene

  1. Identification and characterization of DEN1, a deneddylase of the ULP family. (PMID: 12759362) Gan-Erdene T. … Wilkinson K.D. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PMID: 15567417) Reverter D. … Lima C.D. (J. Mol. Biol. 2005) 3 4 22 64
  3. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PMID: 12730221) Mendoza H.M. … Hay R.T. (J. Biol. Chem. 2003) 2 3 4 64
  4. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PMID: 12759363) Wu K. … Pan Z.-Q. (J. Biol. Chem. 2003) 3 4 22 64
  5. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. (PMID: 19328766) Engels I.H. … Brinker A. (Anal. Biochem. 2009) 3 22 64

Products for SENP8 Gene

Sources for SENP8 Gene

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