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Aliases for SENP7 Gene

Aliases for SENP7 Gene

  • SUMO1/Sentrin Specific Peptidase 7 2 3 5
  • Sentrin/SUMO-Specific Protease SENP7 4
  • SUMO1/Sentrin Specific Protease 7 2
  • SUMO-1-Specific Protease 2 4
  • EC 3.4.22.68 4
  • KIAA1707 4
  • SUSP2 4
  • SSP2 4

External Ids for SENP7 Gene

Previous GeneCards Identifiers for SENP7 Gene

  • GC03M097695
  • GC03M100470
  • GC03M102324
  • GC03M102364
  • GC03M102525
  • GC03M101043
  • GC03M098411

Summaries for SENP7 Gene

Entrez Gene Summary for SENP7 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP7 Gene

SENP7 (SUMO1/Sentrin Specific Peptidase 7) is a Protein Coding gene. Diseases associated with SENP7 include Stargardt Disease and Malaria. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.

UniProtKB/Swiss-Prot for SENP7 Gene

  • Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Gene Wiki entry for SENP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP7 Gene

Genomics for SENP7 Gene

Regulatory Elements for SENP7 Gene

Enhancers for SENP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G101466 1.1 Ensembl ENCODE 26.6 +46.8 46770 1.0 HDAC1 PKNOX1 FOXA2 ZNF792 SAP130 NFRKB ZFP64 ARID4B SIN3A DMAP1 SENP7 NXPE3 ENSG00000201554 GC03M101474
GH03G101560 1.1 ENCODE 24.8 -48.2 -48180 2.3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 SENP7 NXPE3 RPL24 ZBTB11-AS1 IMPG2 PDCL3P4 TRMT10C PCNP
GH03G101511 1.6 Ensembl ENCODE dbSUPER 16.6 +1.2 1153 3.3 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 KLF13 ZNF263 SP3 SP5 SENP7 ZBTB11-AS1 NXPE3 GC03M101474
GH03G101529 1.3 ENCODE dbSUPER 16.4 -17.6 -17570 4.3 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 FOS KLF13 CAVIN1 NCOA1 SENP7 TRMT10C IMPG2 PDCL3P4 FAM172BP
GH03G101517 1.1 ENCODE dbSUPER 16.6 -4.8 -4839 1.4 PKNOX1 FOXA2 CBX3 TBL1XR1 YY1 EGR1 CBX5 FOS RELB ETV6 SENP7 TRMT10C ZBTB11-AS1 FAM172BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SENP7 on UCSC Golden Path with GeneCards custom track

Promoters for SENP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155764 983 1801 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB7B YY1 KLF13 ZNF263 SP3

Genomic Location for SENP7 Gene

Chromosome:
3
Start:
101,324,189 bp from pter
End:
101,513,883 bp from pter
Size:
189,695 bases
Orientation:
Minus strand

Genomic View for SENP7 Gene

Genes around SENP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP7 Gene

Proteins for SENP7 Gene

  • Protein details for SENP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQF6-SENP7_HUMAN
    Recommended name:
    Sentrin-specific protease 7
    Protein Accession:
    Q9BQF6
    Secondary Accessions:
    • A1L3A5
    • A8MW39
    • B7WNW8
    • Q7Z3F4
    • Q96PS5
    • Q9C0F6
    • Q9HBT5

    Protein attributes for SENP7 Gene

    Size:
    1050 amino acids
    Molecular mass:
    119658 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP7 Gene

    Alternative splice isoforms for SENP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP7 Gene

Post-translational modifications for SENP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP7 Gene

Domains & Families for SENP7 Gene

Gene Families for SENP7 Gene

Protein Domains for SENP7 Gene

Suggested Antigen Peptide Sequences for SENP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQF6

UniProtKB/Swiss-Prot:

SENP7_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP7: view

Function for SENP7 Gene

Molecular function for SENP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Enzyme Numbers (IUBMB) for SENP7 Gene

Gene Ontology (GO) - Molecular Function for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 20562864
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SENP7: view
genes like me logo Genes that share phenotypes with SENP7: view

Animal Models for SENP7 Gene

MGI Knock Outs for SENP7:

Animal Model Products

CRISPR Products

miRNA for SENP7 Gene

miRTarBase miRNAs that target SENP7

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SENP7 Gene

Localization for SENP7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP7 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SENP7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SENP7 Gene

Pathways & Interactions for SENP7 Gene

SuperPathways for SENP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with SENP7: view

No data available for Pathways by source and SIGNOR curated interactions for SENP7 Gene

Drugs & Compounds for SENP7 Gene

No Compound Related Data Available

Transcripts for SENP7 Gene

Unigene Clusters for SENP7 Gene

SUMO1/sentrin specific peptidase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SENP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4:
SP5: -
SP6:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SENP7 Gene

GeneLoc Exon Structure for
SENP7
ECgene alternative splicing isoforms for
SENP7

Expression for SENP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SENP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP7 Gene

This gene is overexpressed in Plasma (21.5), Peripheral blood mononuclear cells (13.0), Kidney (10.0), Blymphocyte (9.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SENP7 Gene



Protein tissue co-expression partners for SENP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SENP7 Gene:

SENP7

SOURCE GeneReport for Unigene cluster for SENP7 Gene:

Hs.529551

Evidence on tissue expression from TISSUES for SENP7 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SENP7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP7 Gene

Orthologs for SENP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP7 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia SENP7 34 35
  • 90.35 (n)
cow
(Bos Taurus)
Mammalia LOC507820 34
  • 88.8 (n)
SENP7 35
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp7 34
  • 81.33 (n)
mouse
(Mus musculus)
Mammalia Senp7 34 16 35
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SENP7 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves SENP7 34 35
  • 59.04 (n)
lizard
(Anolis carolinensis)
Reptilia SENP7 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia senp7 34
  • 61.02 (n)
zebrafish
(Danio rerio)
Actinopterygii senp7 35
  • 27 (a)
OneToMany
SENP7 (2 of 2) 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12717 36 35
  • 37 (a)
CG10107 35
  • 3 (a)
ManyToMany
CG41423 35
  • 1 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-4 35
  • 4 (a)
ManyToMany
ulp-2 35
  • 2 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for SENP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP7 Gene

ENSEMBL:
Gene Tree for SENP7 (if available)
TreeFam:
Gene Tree for SENP7 (if available)

Paralogs for SENP7 Gene

Paralogs for SENP7 Gene

genes like me logo Genes that share paralogs with SENP7: view

Variants for SENP7 Gene

Sequence variations from dbSNP and Humsavar for SENP7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000000241 -- 101,476,277(+) CCAGT(A/G)TGTGA intron-variant
rs1000000322 -- 101,387,696(+) AGGTA(C/T)TTCCT intron-variant
rs1000009165 -- 101,432,613(+) AGAAA(A/G)TAAGG intron-variant
rs1000015585 -- 101,339,004(+) CATAA(G/T)GAAGA intron-variant
rs1000024397 -- 101,513,342(+) CTTCC(C/T)GGGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SENP7 Gene

Variant ID Type Subtype PubMed ID
dgv779e201 CNV deletion 23290073
esv1929626 CNV deletion 18987734
esv2677578 CNV deletion 23128226
esv2725701 CNV deletion 23290073
esv2725702 CNV deletion 23290073
esv2725704 CNV deletion 23290073
esv3562295 CNV deletion 23714750
esv3562296 CNV deletion 23714750
nsv1003475 CNV gain 25217958
nsv1112386 CNV deletion 24896259
nsv1142365 CNV tandem duplication 24896259
nsv1152266 CNV deletion 26484159
nsv507111 OTHER sequence alteration 20534489
nsv513063 CNV loss 21212237
nsv954350 CNV deletion 24416366
nsv954362 CNV deletion 24416366
nsv967045 CNV duplication 23825009
nsv967046 CNV duplication 23825009
nsv979862 CNV duplication 23825009

Variation tolerance for SENP7 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.15; 90.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SENP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP7 Gene

Disorders for SENP7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SENP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
stargardt disease
  • stargardt disease-1
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search SENP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP7
genes like me logo Genes that share disorders with SENP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP7 Gene

Publications for SENP7 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PMID: 18799455) Lima C.D. … Reverter D. (J. Biol. Chem. 2008) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64

Products for SENP7 Gene

  • Addgene plasmids for SENP7

Sources for SENP7 Gene

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