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Aliases for SENP7 Gene

Aliases for SENP7 Gene

  • SUMO1/Sentrin Specific Peptidase 7 2 3 5
  • Sentrin/SUMO-Specific Protease SENP7 4
  • SUMO1/Sentrin Specific Protease 7 2
  • SUMO-1-Specific Protease 2 4
  • EC 4
  • KIAA1707 4
  • SUSP2 4
  • SSP2 4

External Ids for SENP7 Gene

Previous GeneCards Identifiers for SENP7 Gene

  • GC03M097695
  • GC03M100470
  • GC03M102324
  • GC03M102364
  • GC03M102525
  • GC03M101043
  • GC03M098411

Summaries for SENP7 Gene

Entrez Gene Summary for SENP7 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP7 Gene

SENP7 (SUMO1/Sentrin Specific Peptidase 7) is a Protein Coding gene. Diseases associated with SENP7 include Malaria and Stargardt Disease. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.

UniProtKB/Swiss-Prot for SENP7 Gene

  • Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Gene Wiki entry for SENP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP7 Gene

Genomics for SENP7 Gene

Regulatory Elements for SENP7 Gene

Enhancers for SENP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SENP7 on UCSC Golden Path with GeneCards custom track

Promoters for SENP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SENP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SENP7 Gene

101,324,189 bp from pter
101,513,883 bp from pter
189,695 bases
Minus strand

Genomic View for SENP7 Gene

Genes around SENP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP7 Gene

Proteins for SENP7 Gene

  • Protein details for SENP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sentrin-specific protease 7
    Protein Accession:
    Secondary Accessions:
    • A1L3A5
    • A8MW39
    • B7WNW8
    • Q7Z3F4
    • Q96PS5
    • Q9C0F6
    • Q9HBT5

    Protein attributes for SENP7 Gene

    1050 amino acids
    Molecular mass:
    119658 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP7 Gene

    Alternative splice isoforms for SENP7 Gene


neXtProt entry for SENP7 Gene

Proteomics data for SENP7 Gene at MOPED

Post-translational modifications for SENP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP7 Gene

Domains & Families for SENP7 Gene

Gene Families for SENP7 Gene

Protein Domains for SENP7 Gene

Suggested Antigen Peptide Sequences for SENP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C48 family.
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP7: view

Function for SENP7 Gene

Molecular function for SENP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Enzyme Numbers (IUBMB) for SENP7 Gene

Gene Ontology (GO) - Molecular Function for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SENP7: view
genes like me logo Genes that share phenotypes with SENP7: view

Animal Models for SENP7 Gene

MGI Knock Outs for SENP7:

Animal Model Products

miRNA for SENP7 Gene

miRTarBase miRNAs that target SENP7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SENP7 Gene

Localization for SENP7 Gene

Subcellular locations from

Jensen Localization Image for SENP7 Gene COMPARTMENTS Subcellular localization image for SENP7 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SENP7 Gene

Pathways & Interactions for SENP7 Gene

SuperPathways for SENP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENP7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SENP7 Gene

Drugs & Compounds for SENP7 Gene

No Compound Related Data Available

Transcripts for SENP7 Gene

Unigene Clusters for SENP7 Gene

SUMO1/sentrin specific peptidase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP5: -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c

Relevant External Links for SENP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SENP7 Gene

mRNA expression in normal human tissues for SENP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP7 Gene

This gene is overexpressed in Plasma (21.5), Peripheral blood mononuclear cells (13.0), Kidney (10.0), Blymphocyte (9.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SENP7 Gene

SOURCE GeneReport for Unigene cluster for SENP7 Gene Hs.529551

genes like me logo Genes that share expression patterns with SENP7: view

Protein tissue co-expression partners for SENP7 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SENP7 Gene

Orthologs for SENP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC507820 35
  • 88.8 (n)
  • 82.68 (a)
SENP7 36
  • 80 (a)
(Canis familiaris)
Mammalia SENP7 35
  • 90.35 (n)
  • 85.43 (a)
SENP7 36
  • 83 (a)
(Mus musculus)
Mammalia Senp7 35
  • 81.22 (n)
  • 71.93 (a)
Senp7 16
Senp7 36
  • 68 (a)
(Pan troglodytes)
Mammalia SENP7 35
  • 99.62 (n)
  • 99.24 (a)
SENP7 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Senp7 35
  • 81.33 (n)
  • 73.02 (a)
(Monodelphis domestica)
Mammalia SENP7 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
-- 36
  • 42 (a)
(Gallus gallus)
Aves SENP7 35
  • 59.04 (n)
  • 47.17 (a)
SENP7 36
  • 39 (a)
(Anolis carolinensis)
Reptilia SENP7 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia senp7 35
  • 61.02 (n)
  • 55.24 (a)
(Danio rerio)
Actinopterygii senp7 36
  • 27 (a)
SENP7 (2 of 2) 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12717 37
  • 37 (a)
CG10107 36
  • 3 (a)
CG12717 36
  • 3 (a)
CG41423 36
  • 1 (a)
(Caenorhabditis elegans)
Secernentea ulp-2 36
  • 2 (a)
ulp-4 36
  • 4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for SENP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP7 Gene

Gene Tree for SENP7 (if available)
Gene Tree for SENP7 (if available)

Paralogs for SENP7 Gene

Paralogs for SENP7 Gene

genes like me logo Genes that share paralogs with SENP7: view

Variants for SENP7 Gene

Sequence variations from dbSNP and Humsavar for SENP7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6809436 - 101,459,004(+) TTTTT(G/T)ATTTT reference, missense
rs2433031 - 101,347,873(-) CAGCA(A/T)TGTGA reference, missense
rs13440 -- 101,324,644(-) TCATA(C/T)GAATC utr-variant-3-prime
rs63482 -- 101,327,063(+) catcc(A/G)ttttg intron-variant
rs722476 -- 101,403,495(-) GATAA(C/T)aggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP7 Gene

Variant ID Type Subtype PubMed ID
nsv507111 CNV Insertion 20534489
nsv513063 CNV Loss 21212237
esv2725701 CNV Deletion 23290073
esv2677578 CNV Deletion 23128226
esv2725702 CNV Deletion 23290073
esv1929626 CNV Deletion 18987734
dgv826e201 CNV Deletion 23290073
esv2725704 CNV Deletion 23290073

Variation tolerance for SENP7 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.15; 90.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SENP7 Gene

Disorders for SENP7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SENP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malaria, severe
stargardt disease
  • stargardt disease 1
- elite association - COSMIC cancer census association via MalaCards
Search SENP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SENP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP7 Gene

Publications for SENP7 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. (PMID: 25895136) GonzA!lez-Prieto R. … Vertegaal A.C. (Cell Cycle 2015) 3
  4. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair. (PMID: 24018422) Garvin A.J. … Morris J.R. (EMBO Rep. 2013) 3
  5. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. (PMID: 23045645) Bawa-Khalfe T. … Yeh E.T. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for SENP7 Gene

Sources for SENP7 Gene