Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SENP7 Gene

Aliases for SENP7 Gene

  • SUMO1/Sentrin Specific Peptidase 7 2 3
  • KIAA1707 4 6
  • Sentrin/SUMO-Specific Protease SENP7 4
  • SUMO1/Sentrin Specific Protease 7 2
  • SUMO-1-Specific Protease 2 4
  • EC 3.4.22.68 4
  • SUSP2 4
  • SSP2 4

External Ids for SENP7 Gene

Summaries for SENP7 Gene

Entrez Gene Summary for SENP7 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP7 Gene

SENP7 (SUMO1/Sentrin Specific Peptidase 7) is a Protein Coding gene. Diseases associated with SENP7 include malaria. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.

UniProtKB/Swiss-Prot for SENP7 Gene

  • Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Gene Wiki entry for SENP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP7 Gene

Genomics for SENP7 Gene

Genomic Location for SENP7 Gene

Start:
101,324,189 bp from pter
End:
101,513,241 bp from pter
Size:
189,053 bases
Orientation:
Minus strand

Genomic View for SENP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP7 Gene

Proteins for SENP7 Gene

  • Protein details for SENP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQF6-SENP7_HUMAN
    Recommended name:
    Sentrin-specific protease 7
    Protein Accession:
    Q9BQF6
    Secondary Accessions:
    • A1L3A5
    • A8MW39
    • B7WNW8
    • Q7Z3F4
    • Q96PS5
    • Q9C0F6
    • Q9HBT5

    Protein attributes for SENP7 Gene

    Size:
    1050 amino acids
    Molecular mass:
    119658 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SENP7 Gene

    Alternative splice isoforms for SENP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP7 Gene

Proteomics data for SENP7 Gene at MOPED

Post-translational modifications for SENP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP7 Gene

Domains for SENP7 Gene

Protein Domains for SENP7 Gene

UniProtKB/Swiss-Prot:

SENP7_HUMAN
Family:
  • Belongs to the peptidase C48 family.:
    • Q9BQF6
genes like me logo Genes that share domains with SENP7: view

No data available for Gene Families for SENP7 Gene

Function for SENP7 Gene

Molecular function for SENP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot Function: Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.

Enzyme Numbers (IUBMB) for SENP7 Gene

Gene Ontology (GO) - Molecular Function for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562864
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SENP7: view

miRNA for SENP7 Gene

miRTarBase miRNAs that target SENP7

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SENP7 Gene

Localization for SENP7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP7 Gene COMPARTMENTS Subcellular localization image for SENP7 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SENP7: view

Pathways for SENP7 Gene

SuperPathways for SENP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SENP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SENP7: view

No data available for Pathways by source for SENP7 Gene

Transcripts for SENP7 Gene

Unigene Clusters for SENP7 Gene

SUMO1/sentrin specific peptidase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4:
SP5: -
SP6:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SENP7 Gene

GeneLoc Exon Structure for
SENP7
ECgene alternative splicing isoforms for
SENP7

Expression for SENP7 Gene

mRNA expression in normal human tissues for SENP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SENP7 Gene

SOURCE GeneReport for Unigene cluster for SENP7 Gene Hs.529551

genes like me logo Genes that share expressions with SENP7: view

Orthologs for SENP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP7 36
  • 99.62 (n)
  • 99.24 (a)
SENP7 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC507820 36
  • 88.8 (n)
  • 82.68 (a)
SENP7 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP7 36
  • 90.35 (n)
  • 85.43 (a)
SENP7 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp7 36
  • 81.22 (n)
  • 71.93 (a)
Senp7 16
Senp7 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SENP7 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
OneToMany
-- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Senp7 36
  • 81.33 (n)
  • 73.02 (a)
chicken
(Gallus gallus)
Aves SENP7 36
  • 59.04 (n)
  • 47.17 (a)
SENP7 37
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP7 37
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia senp7 36
  • 61.02 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii senp7 37
  • 27 (a)
OneToMany
SENP7 (2 of 2) 37
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10107 37
  • 3 (a)
ManyToMany
CG12717 37
  • 3 (a)
ManyToMany
CG41423 37
  • 1 (a)
ManyToMany
CG12717 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea ulp-2 37
  • 2 (a)
ManyToMany
ulp-4 37
  • 4 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 37
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for SENP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP7 Gene

ENSEMBL:
Gene Tree for SENP7 (if available)
TreeFam:
Gene Tree for SENP7 (if available)

Paralogs for SENP7 Gene

Paralogs for SENP7 Gene

genes like me logo Genes that share paralogs with SENP7: view

Variants for SENP7 Gene

Sequence variations from dbSNP and Humsavar for SENP7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13440 -- 101,324,644(-) TCATA(C/T)GAATC utr-variant-3-prime
rs63482 -- 101,327,063(+) catcc(A/G)ttttg intron-variant
rs473702 -- 101,327,133(+) tgcca(A/G)ttaca intron-variant
rs485037 -- 101,334,500(-) ATTCA(A/G)ATGAA intron-variant
rs485793 -- 101,334,522(-) CATAG(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP7 Gene

Variant ID Type Subtype PubMed ID
nsv507111 CNV Insertion 20534489
nsv513063 CNV Loss 21212237
esv2725701 CNV Deletion 23290073
esv2677578 CNV Deletion 23128226
esv2725702 CNV Deletion 23290073
esv1929626 CNV Deletion 18987734
dgv826e201 CNV Deletion 23290073
esv2725704 CNV Deletion 23290073

Relevant External Links for SENP7 Gene

HapMap Linkage Disequilibrium report
SENP7

Disorders for SENP7 Gene

(1) MalaCards Diseases for SENP7 Gene

Search for SENP7 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SENP7 Gene

Disease -log(P) Hits PubMed IDs
malaria 54 1
genes like me logo Genes that share disorders with SENP7: view

No data available for UniProtKB/Swiss-Prot for SENP7 Gene

Publications for SENP7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PMID: 18799455) Lima C.D. … Reverter D. (J. Biol. Chem. 2008) 3 4
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for SENP7 Gene

  • Addgene plasmids for SENP7

Sources for SENP7 Gene

Back to Top

Content