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SENP7 Gene

protein-coding   GIFtS: 51
GCID: GC03M101043

SUMO1/Sentrin Specific Peptidase 7

(Previous name: SUMO1/sentrin specific protease 7)
  See SENP7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin Specific Peptidase 71 2     Sentrin-Specific Protease 72
Sentrin/SUMO-Specific Protease SENP72 3     EC 3.4.22.683
SUMO-1-Specific Protease 22 3     SSP23
KIAA17073 5     SUSP23
SUMO1/Sentrin Specific Protease 71     

External Ids:    HGNC: 304021   Entrez Gene: 573372   Ensembl: ENSG000001384687   OMIM: 6128465   UniProtKB: Q9BQF63   

Export aliases for SENP7 gene to outside databases

Previous GC identifers: GC03M097695 GC03M100470 GC03M102324 GC03M102364 GC03M102525 GC03M098411


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP7 Gene:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins
(see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process
SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display
isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed
18799455)).(supplied by OMIM, Jun 2009)

GeneCards Summary for SENP7 Gene:
SENP7 (SUMO1/sentrin specific peptidase 7) is a protein-coding gene. Diseases associated with SENP7 include malaria. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP6.

UniProtKB/Swiss-Prot: SENP7_HUMAN, Q9BQF6
Function: Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the
deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO
proteins to their mature forms

Gene Wiki entry for SENP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP7 gene promoter:
         USF1   USF2   USF-1:USF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Meis-1b   USF-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP7 promoter sequence
   Search Chromatin IP Primers for SENP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12

SENP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M101043:  view genomic region     (about GC identifiers)

Start:
101,043,049 bp from pter      End:
101,232,085 bp from pter
Size:
189,037 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SENP7_HUMAN, Q9BQF6 (See protein sequence)
Recommended Name: Sentrin-specific protease 7  
Size: 1050 amino acids; 119658 Da
1 PDB 3D structure from and Proteopedia for SENP7:
3EAY (3D)    
Secondary accessions: A1L3A5 A8MW39 B7WNW8 Q7Z3F4 Q96PS5 Q9C0F6 Q9HBT5
Alternative splicing: 5 isoforms:  Q9BQF6-1   Q9BQF6-2   Q9BQF6-3   Q9BQF6-4   Q9BQF6-5   

Explore the universe of human proteins at neXtProt for SENP7: NX_Q9BQF6

Explore proteomics data for SENP7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SENP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001070671.1  NP_001269730.1  NP_001269731.1  NP_001269732.1  NP_001269733.1  NP_065705.3  

    ENSEMBL proteins: 
     ENSP00000377655   ENSP00000377651   ENSP00000377654   ENSP00000313624   ENSP00000377647  
     ENSP00000342159   ENSP00000402977   ENSP00000350936  

    SENP7 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SENP7

     
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    antibodies-online proteins for SENP7 (6 products) 

     
    antibodies-online peptides for SENP7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9BQF6

    ProtoNet protein and cluster: Q9BQF6

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP7_HUMAN, Q9BQF6
    Similarity: Belongs to the peptidase C48 family


    Find genes that share domains with SENP7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP7_HUMAN, Q9BQF6
    Function: Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the
    deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO
    proteins to their mature forms
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Number (IUBMB): EC 3.4.22.681

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity IEA--
         
    Find genes that share ontologies with SENP7           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SENP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target SENP7:
    hsa-let-7a-3p (MIRT039004), hsa-mir-421 (MIRT039376)

    Block miRNA regulation of human, mouse, rat SENP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP7 (see all 20):
    hsa-miR-217 hsa-miR-3200-5p hsa-miR-185* hsa-miR-4251 hsa-miR-522 hsa-miR-509-5p hsa-miR-485-3p hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidSENP7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SENP7

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP7
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    Addgene plasmids for SENP7 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--

    Find genes that share ontologies with SENP7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP7
    Interactions:

        Search GeneGlobe Interaction Network for SENP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP7 (Q9BQF63 ENSP000003776554) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    ENSG00000228532ENSP000003912664STRING: ENSP00000391266
    SENP1ENSP000003947914STRING: ENSP00000394791
    CBX5ENSP000002098754STRING: ENSP00000209875
    UBE2IENSP000003248974STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with SENP7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SENP7 gene (6 alternative transcripts): 
    NM_001077203.2  NM_001282801.1  NM_001282802.1  NM_001282803.1  NM_001282804.1  NM_020654.4  

    Unigene Cluster for SENP7:

    SUMO1/sentrin specific peptidase 7
    Hs.529551  [show with all ESTs]
    Unigene Representative Sequence: NM_020654
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394095(uc003dut.3 uc003duv.3) ENST00000394091(uc003dus.3)
    ENST00000394094(uc003duu.3) ENST00000314261(uc003duw.3 uc003dux.3)
    ENST00000394085 ENST00000348610 ENST00000460107 ENST00000366089 ENST00000358203

    miRNA
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    Block miRNA regulation of human, mouse, rat SENP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP7 (see all 20):
    hsa-miR-217 hsa-miR-3200-5p hsa-miR-185* hsa-miR-4251 hsa-miR-522 hsa-miR-509-5p hsa-miR-485-3p hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidSENP7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SENP7
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SENP7 (NM_020654)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP7
    Addgene plasmids for SENP7 
    Primer
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    OriGene qPCR primer pairs and template standards for SENP7
    OriGene qSTAR qPCR primer pairs in human, mouse for SENP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP7
      QuantiTect SYBR Green Assays in human, mouse, rat SENP7
      QuantiFast Probe-based Assays in human, mouse, rat SENP7

    Additional mRNA sequence: 

    AB051494.1 AF199458.1 AF217504.1 AK297356.1 AL136599.1 AL833577.1 BC039900.1 BC062674.1 
    BC129988.1 BX537943.1 

    9 DOTS entries:

    DT.100022635  DT.99973347  DT.95373139  DT.95373138  DT.91700053  DT.75100824  DT.100741188  DT.95261840 
    DT.120909450 

    Selected AceView cDNA sequences (see all 125):

    BU633779 AI088101 BC039900 AA961981 CN482248 BC062674 AI674230 AA651903 
    AI858732 AI275118 BQ631278 BQ721151 BQ931899 AI937850 BQ631555 BE677122 
    AW517941 AL046115 BQ631285 BP355938 BP354387 AA827717 BX106283 AL045957 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SENP7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
    SP1:                                      -                                                                       -                 -     -     -               
    SP2:                                            -                                                                 -                 -     -     -               
    SP3:                    -                 -     -                                                                 -                 -     -     -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                                             

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SENP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SENP7 Expression
    About this image


    SENP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Eye (Sensory Organs)
             Retina
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    SENP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529551
        Custom PCR Arrays for SENP7
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    QuantiFast Probe-based Assays in human, mouse, rat SENP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp71 , 5 SUMO1/sentrin specific peptidase 71, 5 81.22(n)1
    71.93(a)1
      16 (33.82 cM)5
    663151  NM_025483.31  NP_079759.21 
     560754095 
    chicken
    (Gallus gallus)
    Aves SENP71 SUMO1/sentrin specific peptidase 7 59.04(n)
    47.17(a)
      769280  XM_001232522.3  XP_001232523.3 
    lizard
    (Anolis carolinensis)
    Reptilia SENP76
    SUMO1/sentrin specific peptidase 7
    40(a)
    1 ↔ 1
    3(173647960-173692396)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ630889.12   -- 75.06(n)    BJ630889.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF999834.12   -- 72.93(n)    CF999834.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127173   -- 37(a)   11B16   --
    worm
    (Caenorhabditis elegans)
    Secernentea ulp-46
    ulp-26
    Protein ULP-2 (ulp-2) mRNA, complete cds
    4(a)
    2(a)
    many ↔ many
    many ↔ many
    II(8129960-8134726) WBGene00006739
    II(4955644-4959875) WBGene00006737
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP26
    Peptidase that deconjugates Smt3/SUMO-1 peptides f...
    5(a)
    1 → many
    IX(292633-295737) YIL031W


    ENSEMBL Gene Tree for SENP7 (if available)
    TreeFam Gene Tree for SENP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP7 gene
    SENP62  
    Selected SIMAP similar genes for SENP7 using alignment to 3 protein entries:     SENP7_HUMAN (see all proteins) (see all similar genes):
    CNOT2    ECD    COX7A2    SCIMP    ZNF568    ATL2
    C19orf47    LAMA5    LRTOMT    ZNF23    ZNHIT3    HGSNAT
    MKRN1    NDUFS7    PSD3    IFT122    KLHDC1    TMEM67

    Find genes that share paralogs with SENP7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SENP7 (see all 3454)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819556631,2
    --101042633(+) TAAATA/GACTTC 2 -- ds50010--------
    rs1156494471,2
    C,F--101042704(+) GCTTTG/ATTCAC 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs105611071,2
    C--101042750(+) AACAT-/ACA   
       CACAC
    ACACA
    2 -- ds50010--------
    rs605571911,2
    C--101042793(+) ACACC-/CCTCTAG 2 -- ds50010--------
    rs738630471,2
    C,F--101042794(+) CACACC/ACCTCT 2 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs1489287621,2
    --101043085(+) TAGCTA/CATGTT 2 -- ds50010--------
    rs748734071,2
    C,F--101043132(+) TGGAAA/GTATGT 2 -- ut311Minor allele frequency- G:0.01NA 120
    rs1428243801,2
    C--101043282(+) GATGTC/TTTATA 2 -- ut310--------
    rs1860491571,2
    --101043482(+) GACCCC/TGATTC 2 -- ut310--------
    rs134401,2
    C,F,O,H--101043488(-) TCATAC/TGAATC 2 -- ut31 ese322Minor allele frequency- T:0.42MN NS EA NA WA CSA 2715

    HapMap Linkage Disequilibrium report for SENP7 (101043049 - 101232085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SENP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv826e201CNV Deletion23290073
    esv2725704CNV Deletion23290073
    esv2725702CNV Deletion23290073
    esv2725701CNV Deletion23290073
    esv1929626CNV Deletion18987734
    esv2677578CNV Deletion23128226
    nsv507111CNV Insertion20534489
    nsv513063CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SENP7
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612846    OMIM disorders: --

    1 disease for SENP7:    
    About MalaCards
    malaria


    Find genes that share disorders with SENP7           About GenesLikeMe

    1 Novoseek inferred disease relationship for SENP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malaria 54 2 8892640 (1)


    Export disorders for SENP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP7 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SENP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PubMed id 18799455)1, 2 Lima C.D. and Reverter D. (J. Biol. Chem. 2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair. (PubMed id 24018422)1 Garvin A.J....Morris J.R. (EMBO Rep. 2013)
    6. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. (PubMed id 23045645)1 Bawa-Khalfe T....Yeh E.T. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7. (PubMed id 21878624)1 Alegre K.O. and Reverter D. (J. Biol. Chem. 2011)
    8. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57337 HGNC: 30402 AceView: SENP7 Ensembl:ENSG00000138468 euGenes: HUgn57337
    ECgene: SENP7 H-InvDB: SENP7

    (According to HUGE)
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    HUGE: KIAA1707

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SENP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SENP7 gene:
    Search GeneIP for patents involving SENP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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