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GIFtS

SENP6 Gene

protein-coding   GIFtS: 53
GCID: GC06P076311

SUMO1/sentrin specific peptidase 6

(Previous name: SUMO1/sentrin specific protease 6 )
 Explore 9 diseases affiliated with
SENP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SENP6    

Aliases
for SENP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SUMO1/Sentrin Specific Peptidase 61 2     Sentrin/SUMO-Specific Protease SENP62 3
SUSP11 2 3 5     SUMO-1-Specific Protease 12 3
SSP12 3 5     2810017C20Rik2
SUMO1/Sentrin Specific Protease 61 2     Sentrin-Specific Protease 62
KIAA07971 3     EC 3.4.22.683

External Ids:    HGNC: 209441   Entrez Gene: 260542   Ensembl: ENSG000001127017   OMIM: 6050035   UniProtKB: Q9GZR13   

Export aliases for SENP6 gene to outside databases

Previous GC identifers: GC06P076308 GC06P076367 GC06P073510


Summaries
for SENP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SENP6:
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339)
and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not
result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM
602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from
degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino
acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL
precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins
(Kim et al., 2000 (PubMed 10799485)). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated
substrates (Lima and Reverter, 2008 (PubMed 18799455)).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
Function: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2
and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from
RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the
kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin
ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus
preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination

Gene Wiki entry for SENP6


Genomic Views
for SENP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SENP6 gene promoter:
         AML1a   Sp1   Egr-1   CUTL1   Nkx2-5   YY1   GATA-1   Egr-2   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SENP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SENP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q14.3   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q13-q14.3

SENP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P076311:  view genomic region     (about GC identifiers)

Start:
 76,311,225 bp from pter      End:
 76,427,997 bp from pter
Size:
 116,773 bases      Orientation:
 plus strand

Proteins
for SENP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1 (See protein sequence)
Recommended Name: Sentrin-specific protease 6  
Size: 1112 amino acids; 126146 Da
Subunit: Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with
RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation
Subcellular location: Nucleus
Sequence caution: Sequence=BAA34517.2; Type=Erroneous initiation; Sequence=CAH72480.1; Type=Erroneous gene model
prediction; Sequence=CAH72481.1; Type=Erroneous gene model prediction; Sequence=CAH74168.1; Type=Erroneous gene model
prediction; Sequence=CAH74170.1; Type=Erroneous gene model prediction; Sequence=CAI19523.1; Type=Erroneous gene model
prediction; Sequence=CAI23575.1; Type=Erroneous gene model prediction; Sequence=CAI23576.1; Type=Erroneous gene model
prediction;
Secondary accessions: A6NNY9 O94891 Q5VUL3 Q5VUL4 Q8TBY4 Q9UJV5
Alternative splicing: 2 isoforms:  Q9GZR1-1   Q9GZR1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SENP6: NX_Q9GZR1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZR1

    • SENP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093879.1  NP_056386.2  

    ENSEMBL proteins: 
     ENSP00000359027   ENSP00000321820   ENSP00000402527   ENSP00000425624   ENSP00000426480  
     ENSP00000391426   ENSP00000422576   ENSP00000359031   ENSP00000441715  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SENP6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    SENP6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SENP6

    Protein Domains /
    Families
    for SENP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SENP6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9GZR1

    ProtoNet protein and cluster: Q9GZR1

    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Similarity: Belongs to the peptidase C48 family


    Function
    for SENP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Function: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2
    and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from
    RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the
    kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin
    ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus
    preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal
    end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second
    reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and
    the lysine epsilon-amino group of the target protein

    Enzyme Number (IUBMB): EC 3.4.22.681

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0016929SUMO-specific protease activity IMP--


    SENP6 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for SENP6:
     Cell division defect  Decreased POU5F1-GFP protein e  Downregulation of NF-kappaB pa  Increased S DNA content, incre 
     Increased cell number in S  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Senp6):
     mortality/aging 

    SENP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SENP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Pathway: Protein modification; protein sumoylation

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SENP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for SENP6 (Q9GZR13 ENSP000004025274) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    ARNTP275403, ENSP000003514074I2D: score=1 STRING: ENSP00000351407
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    SCHIP1Q9P0W53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0016925protein sumoylation IEA--
    GO:0016926protein desumoylation IMP--
    GO:0070646protein modification by small protein removal IDA--
    GO:0090169regulation of spindle assembly IMP--


    SENP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SENP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SENP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SENP6
    1 Novoseek chemical compound relationship for SENP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 21 1 10799485 (1)

    Search CenterWatch for drugs/clinical trials and news about SENP6 

    Transcripts
    for SENP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SENP6 gene (2 alternative transcripts): 
    NM_001100409.1  NM_015571.2  

    Unigene Cluster for SENP6:

    SUMO1/sentrin specific peptidase 6
    Hs.485784  [show with all ESTs]
    Unigene Representative Sequence: NM_015571
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370010 ENST00000327284(uc003pic.2) ENST00000447266(uc010kbf.3)
    ENST00000493959 ENST00000483859 ENST00000487548 ENST00000424947(uc003pif.1)
    ENST00000436928 ENST00000485497 ENST00000503501 ENST00000476060 ENST00000474906
    ENST00000370014(uc003pid.4 uc003pie.4) ENST00000541192

    miRNA
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    hsa-miR-607 hsa-miR-300 hsa-miR-628-3p hsa-miR-374c hsa-miR-4325 hsa-miR-3908 hsa-miR-186 hsa-miR-325
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB018340.2 AF196304.1 AF306508.1 AF307849.1 AK001406.1 AK021949.1 AK096455.1 AK126921.1 
    BC028583.1 

    19 DOTS entries:

    DT.445489  DT.100027511  DT.100027512  DT.75143544  DT.40202621  DT.121375357  DT.95262886  DT.100027514 
    DT.100791678  DT.100671128  DT.40110058  DT.40193628  DT.92441257  DT.121375317  DT.411020  DT.91683959 
    DT.95093934  DT.100663568  DT.75173930 

    24/330 AceView cDNA sequences (see all 330):

    AA323197 BM469320 BG105884 BU509105 AA768785 CB160450 AU116855 AA962641 
    BU683534 AK021417 BX483415 BF089742 CD723524 AA010765 BG621481 Z42655 
    BG028263 BE669490 AA442800 BX482516 AA918925 BF797315 BM802622 AU120050 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SENP6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                                                                                                                                  -         
    SP2:                                                                                                        -                                                   
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SENP6

    Expression
    for SENP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SENP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAATGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SENP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SENP6

    SOURCE GeneReport for Unigene cluster: Hs.485784

    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Tissue specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate

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    In Situ
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    Orthologs
    for SENP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SENP6 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SENP61 SUMO1/sentrin specific peptidase 6 72.51(n)
    67.67(a)    		   421859  XM_001235415.2  XP_001235416.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SENP66
    		 --
    		 62(a)
    		 1 ↔ 1
    		 1(201196523-201279500)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.145572 Xenopus laevis transcribed sequence with weak similarity more 78.63(n)    BX852833.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.39492 Transcribed sequence with weak similarity to protein more 74.27(n)    BM889881.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG127176
    CG414236
    (see all 3)    		 --
    		 21(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 X(12654911-12657644)
    U(2927697-2928954)
    worm
    (Caenorhabditis elegans)    		 Secernentea ulp-46
    ulp-26
    		 Ubiquitin-Like Protease family member (ulp-2)
    		 20(a)
    11(a)
    		 1 ↔ many
    possible ortholog
    		 II(8129908-8133210)
    II(4955638-4959869)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons OTS16
    OTS26
    (see all 4)    		 ubiquitin-like-specific protease 1C
    (see all 4)    		 15(a)
    14(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(22208332-22212171)
    1(3487584-3491277)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 ulp1 protease family protein, putative, expressed
    (see all 4)    		 15(a)
    13(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 6(16731926-16744664)
    1(30787686-30795512)


    ENSEMBL Gene Tree for SENP6 (if available)
    TreeFam Gene Tree for SENP6 (if available) 

    Paralogs
    for SENP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SENP6 gene
    SENP72  
    1 SIMAP similar gene for SENP6 using alignment to 10 protein entries:     SENP6_HUMAN (see all proteins):
    SENP7

    SENP6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SENP6
    PGOHUM00000243215 PGOHUM00000250179


    Genomic Variants
    for SENP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2032 NCBI SNPs in SENP6 are shown (see all 2032)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1841488731,2
    		--76309795(+) AAACAA/GAAATC 2 -- us2k10--------
    rs1423312931,2
    		--76309867(+) TAATTG/TAGCAA 2 -- us2k10--------
    rs1505952551,2
    		--76309895(+) TCTGAC/TAGTTC 2 -- us2k10--------
    rs734510711,2
    		C,F,--76310042(+) GGCACC/ATTCTT 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1888901431,2
    		--76310071(+) TATATA/GCATTT 2 -- us2k10--------
    rs1497218511,2
    		--76310274(+) GAGTAG/TCTGAG 2 -- us2k10--------
    rs1926676701,2
    		--76310369(+) AACTCA/CTCCCG 2 -- us2k10--------
    rs1132447901,2
    		C,F,--76310375(+) TCCCGT/ACCTCA 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs119679571,2
    		C,H,--76310519(+) CCTACA/GCTTCT 2 -- us2k13Minor allele frequency- G:0.03NA CSA WA 210
    rs1396617201,2
    		--76310567(+) AACACA/CACAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SENP6 (76311225 - 76427997 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SENP6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP6
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP6

    Disorders / Diseases
    for SENP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SENP6 for disorders           About GeneDecksing

    OMIM gene information: 605003    OMIM disorders: --

    9 diseases for SENP6:    About MalaCards
    dentinogenesis imperfecta    severe acute respiratory syndrome    sarcocystosis    dysentery
    kaposi's sarcoma    sarcoma    prostate cancer    leukemia
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for SENP6:
    Sarcocystosis     Severe acute respiratory syndrome

    1 Novoseek disease relationship for SENP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 68 1 17000875 (1)


    Export disorders for SENP6 gene to outside databases

    Publications
    for SENP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SENP6 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SENP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. (PubMed id 10799485)1, 2, 9 Kim K.I.... Chung C.H. (2000)
    2. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PubMed id 17000875)1, 2, 9 Mukhopadhyay D.... Dasso M. (2006)
    3. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. (PubMed id 21148299)1, 2 Hattersley N.... Hay R.T. (2011)
    4. The SUMO protease SENP6 is essential for inner kineto chore assembly. (PubMed id 20212317)1, 2 Mukhopadhyay D....Dasso M. (2010)
    5. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PubMed id 17704809)1, 2 Cheng Z....Yao X. (2008)
    6. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PubMed id 18799455)1, 2 Lima C.D. and Reverter D. (2008)
    7. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. (PubMed id 16912044)1, 2 Choi S.J.... Chung C.H. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)

    External Searches for SENP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SENP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26054 HGNC: 20944 AceView: SENP6 Ensembl:ENSG00000112701 euGenes: HUgn26054
    ECgene: SENP6 H-InvDB: SENP6

    Other Databases showing SENP6 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0797

    Specialized Databases showing SENP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SENP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SENP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SENP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SENP6 gene:
    Search GeneIP for patents involving SENP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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