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SENP6 Gene

protein-coding   GIFtS: 56
GCID: GC06P076311

SUMO1/Sentrin Specific Peptidase 6

(Previous name: SUMO1/sentrin specific protease 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin Specific Peptidase 61 2     SUMO-1-Specific Protease 12 3
SSP12 3 5     2810017C20Rik2
SUSP12 3 5     Sentrin-Specific Protease 62
SUMO1/Sentrin Specific Protease 61 2     EC 3.4.22.683
Sentrin/SUMO-Specific Protease SENP62 3     KIAA07973

External Ids:    HGNC: 209441   Entrez Gene: 260542   Ensembl: ENSG000001127017   OMIM: 6050035   UniProtKB: Q9GZR13   

Export aliases for SENP6 gene to outside databases

Previous GC identifers: GC06P076308 GC06P076367 GC06P073510


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP6 Gene:
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM
191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of
UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting
of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM
164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with
1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail
sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their
conjugation to target proteins (Kim et al., 2000 (PubMed 10799485)). SENPs also display isopeptidase activity for
deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed 18799455)).(supplied by OMIM, Jun
2009)

GeneCards Summary for SENP6 Gene:
SENP6 (SUMO1/sentrin specific peptidase 6) is a protein-coding gene. Diseases associated with SENP6 include sarcocystosis, and dysentery. GO annotations related to this gene include SUMO-specific protease activity. An important paralog of this gene is SENP7.

UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
Function: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially
poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors.
Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle
assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them
from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation.
Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair
through homologous recombination

Gene Wiki entry for SENP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP6 gene promoter:
         AML1a   Sp1   Egr-1   CUTL1   Nkx2-5   YY1   GATA-1   Egr-2   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP6 promoter sequence
   Search Chromatin IP Primers for SENP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q14.3   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q13-q14.3

SENP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P076311:  view genomic region     (about GC identifiers)

Start:
76,311,225 bp from pter      End:
76,427,997 bp from pter
Size:
116,773 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1 (See protein sequence)
Recommended Name: Sentrin-specific protease 6  
Size: 1112 amino acids; 126146 Da
Subunit: Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts
with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation
Sequence caution: Sequence=BAA34517.2; Type=Erroneous initiation; Sequence=CAH72480.1; Type=Erroneous gene model
prediction; Sequence=CAH72481.1; Type=Erroneous gene model prediction; Sequence=CAH74168.1; Type=Erroneous gene
model prediction; Sequence=CAH74170.1; Type=Erroneous gene model prediction; Sequence=CAI19523.1; Type=Erroneous
gene model prediction; Sequence=CAI23575.1; Type=Erroneous gene model prediction; Sequence=CAI23576.1;
Type=Erroneous gene model prediction;
Secondary accessions: A6NNY9 O94891 Q5VUL3 Q5VUL4 Q8TBY4 Q9UJV5
Alternative splicing: 2 isoforms:  Q9GZR1-1   Q9GZR1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SENP6: NX_Q9GZR1

Explore proteomics data for SENP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SENP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093879.1  NP_056386.2  

    ENSEMBL proteins: 
     ENSP00000359027   ENSP00000321820   ENSP00000402527   ENSP00000425624   ENSP00000426480  
     ENSP00000391426   ENSP00000422576   ENSP00000359031   ENSP00000441715  

    SENP6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SENP6

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    SENP6 Assay Products:

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    Cloud-Clone Corp. CLIAs for SENP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9GZR1

    ProtoNet protein and cluster: Q9GZR1

    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Similarity: Belongs to the peptidase C48 family


    SENP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP6_HUMAN, Q9GZR1
    Function: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially
    poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors.
    Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle
    assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them
    from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation.
    Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair
    through homologous recombination
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Number (IUBMB): EC 3.4.22.681

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0016929SUMO-specific protease activity IMP--
         
    SENP6 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for SENP6:
     Cell division defect  Decreased POU5F1-GFP protein e  Downregulation of NF-kappaB pa  Increased S DNA content, incre 
     Increased cell number in S  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Senp6):
     mortality/aging 

    SENP6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SENP6
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    miRNA
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    miRTarBase miRNAs that target SENP6:
    hsa-mir-16-5p (MIRT051074)

    Block miRNA regulation of human, mouse, rat SENP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP6 (see all 40):
    hsa-miR-607 hsa-miR-300 hsa-miR-628-3p hsa-miR-374c hsa-miR-4325 hsa-miR-3908 hsa-miR-186 hsa-miR-325
    SwitchGear 3'UTR luciferase reporter plasmidSENP6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SENP6
    Predesigned siRNA for gene silencing in human, mouse, rat SENP6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SENP6 (NM_015571)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SENP6_HUMAN, Q9GZR1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    SENP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Pathway: Protein modification; protein sumoylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP6
    Interactions:

        GeneGlobe Interaction Network for SENP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP6 (Q9GZR13 ENSP000004025274) via UniProtKB, MINT, STRING, and/or I2D (see all 83)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    ARNTP275403, ENSP000003514074I2D: score=1 STRING: ENSP00000351407
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    SCHIP1Q9P0W53I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0016925protein sumoylation IEA--
    GO:0016926protein desumoylation IMP--
    GO:0070646protein modification by small protein removal IDA--
    GO:0090169regulation of spindle assembly IMP--

    SENP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP6

    1 Novoseek inferred chemical compound relationship for SENP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 21 1 10799485 (1)



    SENP6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SENP6 gene (2 alternative transcripts): 
    NM_001100409.1  NM_015571.2  

    Unigene Cluster for SENP6:

    SUMO1/sentrin specific peptidase 6
    Hs.485784  [show with all ESTs]
    Unigene Representative Sequence: NM_015571
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370010 ENST00000327284(uc003pic.2) ENST00000447266(uc010kbf.3)
    ENST00000493959 ENST00000483859 ENST00000487548 ENST00000424947(uc003pif.1)
    ENST00000436928 ENST00000485497 ENST00000503501 ENST00000476060 ENST00000474906
    ENST00000370014(uc003pid.4 uc003pie.4) ENST00000541192
    miRNA
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    Block miRNA regulation of human, mouse, rat SENP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP6 (see all 40):
    hsa-miR-607 hsa-miR-300 hsa-miR-628-3p hsa-miR-374c hsa-miR-4325 hsa-miR-3908 hsa-miR-186 hsa-miR-325
    SwitchGear 3'UTR luciferase reporter plasmidSENP6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SENP6 (NM_015571)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP6
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP6
      QuantiTect SYBR Green Assays in human, mouse, rat SENP6
      QuantiFast Probe-based Assays in human, mouse, rat SENP6

    Additional mRNA sequence: 

    AB018340.2 AF196304.1 AF306508.1 AF307849.1 AK001406.1 AK021949.1 AK096455.1 AK126921.1 
    BC028583.1 

    19 DOTS entries:

    DT.445489  DT.100027511  DT.100027512  DT.75143544  DT.40202621  DT.121375357  DT.95262886  DT.100027514 
    DT.100791678  DT.100671128  DT.40110058  DT.40193628  DT.92441257  DT.121375317  DT.411020  DT.91683959 
    DT.95093934  DT.100663568  DT.75173930 

    Selected AceView cDNA sequences (see all 330):

    BM469320 AA323197 BU509105 BG105884 CB160450 AA768785 AU116855 AA962641 
    BU683534 AK021417 BX483415 BF089742 CD723524 AA010765 BG621481 Z42655 
    BG028263 AA442800 BE669490 BX482516 AA918925 BF797315 BM802622 AU120050 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SENP6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                                                                                                                                  -         
    SP2:                                                                                                        -                                                   
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SENP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATGCTGT
    SENP6 Expression
    About this image


    SENP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thyroid (Endocrine System)
    SENP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485784

    UniProtKB/Swiss-Prot: SENP6_HUMAN, Q9GZR1
    Tissue specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate

        Custom PCR Arrays for SENP6
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    QuantiFast Probe-based Assays in human, mouse, rat SENP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp61 , 5 SUMO/sentrin specific peptidase 61, 5 85.05(n)1
    82.1(a)1
      9 (43.88 cM)5
    2153511  NM_146003.21  NP_666115.21 
     800669035 
    chicken
    (Gallus gallus)
    Aves SENP61 SUMO1/sentrin specific peptidase 6 73.08(n)
    68.83(a)
      421859  XM_001235415.3  XP_001235416.3 
    lizard
    (Anolis carolinensis)
    Reptilia SENP66
    SUMO1/sentrin specific peptidase 6
    59(a)
    1 ↔ 1
    1(201192860-201298713)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145572 Xenopus laevis transcribed sequence with weak similarity more 78.63(n)    BX852833.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.39492 Transcribed sequence with weak similarity to protein more 74.27(n)    BM889881.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127176
    CG101076
    (see all 3)
    --
    4(a)
    3(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(12654911-12657644)
    3L(6737526-6745386)
    worm
    (Caenorhabditis elegans)
    Secernentea ulp-46
    ulp-26
    Protein ULP-2 (ulp-2) mRNA, complete cds
    5(a)
    3(a)
    many ↔ many
    many ↔ many
    II(8129960-8134726) WBGene00006739
    II(4955644-4959875) WBGene00006737
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP26
    Peptidase that deconjugates Smt3/SUMO-1 peptides f...
    6(a)
    1 → many
    IX(292633-295737) YIL031W


    ENSEMBL Gene Tree for SENP6 (if available)
    TreeFam Gene Tree for SENP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP6 gene
    SENP72  
    1 SIMAP similar gene for SENP6 using alignment to 10 protein entries:     SENP6_HUMAN (see all proteins):
    SENP7

    SENP6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SENP6
    PGOHUM00000243215 PGOHUM00000250179


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SENP6 (see all 2458)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841488731,2
    --76309795(+) AAACAA/GAAATC 2 -- us2k10--------
    rs1423312931,2
    --76309867(+) TAATTG/TAGCAA 2 -- us2k10--------
    rs1505952551,2
    --76309895(+) TCTGAC/TAGTTC 2 -- us2k10--------
    rs734510711,2
    C,F--76310042(+) GGCACC/ATTCTT 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1888901431,2
    --76310071(+) TATATA/GCATTT 2 -- us2k10--------
    rs1497218511,2
    --76310274(+) GAGTAG/TCTGAG 2 -- us2k10--------
    rs1926676701,2
    --76310369(+) AACTCA/CTCCCG 2 -- us2k10--------
    rs1132447901,2
    C,F--76310375(+) TCCCGT/ACCTCA 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs119679571,2
    C,F,H--76310519(+) CCTACA/GCTTCT 2 -- us2k13Minor allele frequency- G:0.03NA CSA WA 210
    rs1396617201,2
    --76310567(+) AACACA/CACAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SENP6 (76311225 - 76427997 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SENP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672891CNV Deletion23128226
    nsv522814CNV Loss19592680
    dgv6907n71CNV Loss21882294
    dgv6908n71CNV Loss21882294
    nsv886183CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SENP6
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605003    OMIM disorders: --

    11 diseases for SENP6:    
    About MalaCards
    sarcocystosis    dysentery    dentinogenesis imperfecta    severe acute respiratory syndrome
    kaposi's sarcoma    sarcoma    prostate cancer    prostatitis
    leukemia    thyroiditis    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for SENP6:
    Sarcocystosis     Severe acute respiratory syndrome

    SENP6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SENP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 68 1 17000875 (1)


    Export disorders for SENP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP6 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SENP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. (PubMed id 10799485)1, 2, 9 Kim K.I.... Chung C.H. (J. Biol. Chem. 2000)
    2. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PubMed id 17000875)1, 2, 9 Mukhopadhyay D.... Dasso M. (J. Cell Biol. 2006)
    3. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. (PubMed id 21148299)1, 2 Hattersley N.... Hay R.T. (Mol. Biol. Cell 2011)
    4. The SUMO protease SENP6 is essential for inner kinetochore assembly. (PubMed id 20212317)1, 2 Mukhopadhyay D.... Dasso M. (J. Cell Biol. 2010)
    5. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PubMed id 17704809)1, 2 Cheng Z.... Yao X. (Oncogene 2008)
    6. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. (PubMed id 18799455)1, 2 Lima C.D. and Reverter D. (J. Biol. Chem. 2008)
    7. Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. (PubMed id 16912044)1, 2 Choi S.J.... Chung C.H. (J. Biol. Chem. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26054 HGNC: 20944 AceView: SENP6 Ensembl:ENSG00000112701 euGenes: HUgn26054
    ECgene: SENP6 H-InvDB: SENP6

    (According to HUGE)
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    HUGE: KIAA0797

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SENP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SENP6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SENP6 gene:
    Search GeneIP for patents involving SENP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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