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Aliases for SENP6 Gene

Aliases for SENP6 Gene

  • SUMO1/Sentrin Specific Peptidase 6 2 3 5
  • Sentrin/SUMO-Specific Protease SENP6 3 4
  • SUMO1/Sentrin Specific Protease 6 2 3
  • SUMO-1-Specific Protease 1 3 4
  • SUSP1 3 4
  • SSP1 3 4
  • 2810017C20Rik 3
  • EC 3.4.22.68 4
  • KIAA0797 4

External Ids for SENP6 Gene

Previous GeneCards Identifiers for SENP6 Gene

  • GC06P076308
  • GC06P076367
  • GC06P076311
  • GC06P073510

Summaries for SENP6 Gene

Entrez Gene Summary for SENP6 Gene

  • Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP6 Gene

SENP6 (SUMO1/Sentrin Specific Peptidase 6) is a Protein Coding gene. Diseases associated with SENP6 include Sarcocystosis. GO annotations related to this gene include cysteine-type peptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP7.

UniProtKB/Swiss-Prot for SENP6 Gene

  • Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene Wiki entry for SENP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP6 Gene

Genomics for SENP6 Gene

Regulatory Elements for SENP6 Gene

Enhancers for SENP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SENP6 on UCSC Golden Path with GeneCards custom track

Promoters for SENP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SENP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SENP6 Gene

Chromosome:
6
Start:
75,601,509 bp from pter
End:
75,718,285 bp from pter
Size:
116,777 bases
Orientation:
Plus strand

Genomic View for SENP6 Gene

Genes around SENP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP6 Gene

Proteins for SENP6 Gene

  • Protein details for SENP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR1-SENP6_HUMAN
    Recommended name:
    Sentrin-specific protease 6
    Protein Accession:
    Q9GZR1
    Secondary Accessions:
    • A6NNY9
    • O94891
    • Q5VUL3
    • Q5VUL4
    • Q8TBY4
    • Q9UJV5

    Protein attributes for SENP6 Gene

    Size:
    1112 amino acids
    Molecular mass:
    126146 Da
    Quaternary structure:
    • Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
    SequenceCaution:
    • Sequence=BAA34517.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH72480.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72481.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH74168.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH74170.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19523.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23575.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23576.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP6 Gene

Proteomics data for SENP6 Gene at MOPED

Post-translational modifications for SENP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP6 Gene

Domains & Families for SENP6 Gene

Gene Families for SENP6 Gene

Protein Domains for SENP6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZR1

UniProtKB/Swiss-Prot:

SENP6_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP6: view

Function for SENP6 Gene

Molecular function for SENP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Enzyme Numbers (IUBMB) for SENP6 Gene

Gene Ontology (GO) - Molecular Function for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016929 SUMO-specific protease activity IMP 20212317
genes like me logo Genes that share ontologies with SENP6: view
genes like me logo Genes that share phenotypes with SENP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP6 Gene

Localization for SENP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP6 Gene COMPARTMENTS Subcellular localization image for SENP6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SENP6: view

Pathways & Interactions for SENP6 Gene

SuperPathways for SENP6 Gene

No Data Available

Pathways by source for SENP6 Gene

1 GeneTex pathway for SENP6 Gene

UniProtKB/Swiss-Prot Q9GZR1-SENP6_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Gene Ontology (GO) - Biological Process for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016925 protein sumoylation IEA --
GO:0016926 protein desumoylation IMP 20212317
genes like me logo Genes that share ontologies with SENP6: view

No data available for SIGNOR curated interactions for SENP6 Gene

Drugs & Compounds for SENP6 Gene

(1) Drugs for SENP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SENP6: view

Transcripts for SENP6 Gene

Unigene Clusters for SENP6 Gene

SUMO1/sentrin specific peptidase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SENP6 Gene

GeneLoc Exon Structure for
SENP6
ECgene alternative splicing isoforms for
SENP6

Expression for SENP6 Gene

mRNA expression in normal human tissues for SENP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Testis (23.1), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SENP6 Gene



SOURCE GeneReport for Unigene cluster for SENP6 Gene Hs.485784

mRNA Expression by UniProt/SwissProt for SENP6 Gene

Q9GZR1-SENP6_HUMAN
Tissue specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate.
genes like me logo Genes that share expression patterns with SENP6: view

Protein tissue co-expression partners for SENP6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SENP6 Gene

Orthologs for SENP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SENP6 35
  • 91.16 (n)
  • 87.73 (a)
SENP6 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP6 35
  • 91.72 (n)
  • 88.21 (a)
SENP6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp6 35
  • 85.05 (n)
  • 82.1 (a)
Senp6 16
Senp6 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SENP6 35
  • 99.64 (n)
  • 99.37 (a)
SENP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp6 35
  • 86.08 (n)
  • 83.42 (a)
oppossum
(Monodelphis domestica)
Mammalia SENP6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves SENP6 35
  • 73.08 (n)
  • 68.83 (a)
SENP6 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP6 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14557 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3949 35
senp6a 35
  • 53.22 (n)
  • 49.27 (a)
senp6a 36
  • 39 (a)
OneToMany
senp6b 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10107 36
  • 3 (a)
ManyToMany
CG12717 36
  • 4 (a)
ManyToMany
CG41423 36
  • 1 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-2 36
  • 3 (a)
ManyToMany
ulp-4 36
  • 5 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for SENP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP6 Gene

ENSEMBL:
Gene Tree for SENP6 (if available)
TreeFam:
Gene Tree for SENP6 (if available)

Paralogs for SENP6 Gene

Paralogs for SENP6 Gene

(1) SIMAP similar genes for SENP6 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for SENP6 Gene

genes like me logo Genes that share paralogs with SENP6: view

Variants for SENP6 Gene

Sequence variations from dbSNP and Humsavar for SENP6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9250 - 75,715,572(+) ACAAT(A/G)TGTCA nc-transcript-variant, reference, missense
rs17414086 - 75,634,715(+) AAATA(C/T)GCAAA nc-transcript-variant, reference, missense
rs1061347 - 75,678,643(+) ATGAA(A/G)AAGAA nc-transcript-variant, reference, missense
rs12195603 - 75,695,878(+) TAAAC(A/C/G)CCTTA nc-transcript-variant, reference, missense
rs34045941 - 75,702,815(-) GCTTG(A/G)CAGAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SENP6 Gene

Variant ID Type Subtype PubMed ID
nsv886183 CNV Loss 21882294
dgv6907n71 CNV Loss 21882294
nsv522814 CNV Loss 19592680
esv2672891 CNV Deletion 23128226
dgv6908n71 CNV Loss 21882294

Variation tolerance for SENP6 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SENP6 Gene

Disorders for SENP6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SENP6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcocystosis
  • sarcosporidiosis
- elite association - COSMIC cancer census association via MalaCards
Search SENP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP6
genes like me logo Genes that share disorders with SENP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP6 Gene

Publications for SENP6 Gene

  1. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. (PMID: 10799485) Kim K.I. … Chung C.H. (J. Biol. Chem. 2000) 3 4 23 67
  2. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PMID: 17000875) Mukhopadhyay D. … Dasso M. (J. Cell Biol. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Structural insights into the SENP6 Loop1 structure in complex with SUMO2. (PMID: 24424631) Alegre K.O. … Reverter D. (Protein Sci. 2014) 3

Products for SENP6 Gene

Sources for SENP6 Gene

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