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Aliases for SENP6 Gene

Aliases for SENP6 Gene

  • SUMO1/Sentrin Specific Peptidase 6 2 3 5
  • Sentrin/SUMO-Specific Protease SENP6 3 4
  • SUMO1/Sentrin Specific Protease 6 2 3
  • SUMO-1-Specific Protease 1 3 4
  • SUSP1 3 4
  • SSP1 3 4
  • Sentrin-Specific Protease 6 3
  • 2810017C20Rik 3
  • EC 3.4.22.68 4
  • KIAA0797 4

External Ids for SENP6 Gene

Previous GeneCards Identifiers for SENP6 Gene

  • GC06P076308
  • GC06P076367
  • GC06P076311
  • GC06P073510

Summaries for SENP6 Gene

Entrez Gene Summary for SENP6 Gene

  • Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP6 Gene

SENP6 (SUMO1/Sentrin Specific Peptidase 6) is a Protein Coding gene. Diseases associated with SENP6 include Sarcocystosis. GO annotations related to this gene include cysteine-type peptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP7.

UniProtKB/Swiss-Prot for SENP6 Gene

  • Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene Wiki entry for SENP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP6 Gene

Genomics for SENP6 Gene

Regulatory Elements for SENP6 Gene

Enhancers for SENP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F075523 1.3 Ensembl ENCODE 22.8 -77.1 -77109 1.3 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 ZNF302 KLF7 SP3 SP5 SENP6 FILIP1 RPL26P20 LOC100506804 TMEM30A RNU1-34P ENSG00000237174 GC06P075549
GH06F075600 1.1 ENCODE 21.9 +0.9 933 3.6 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 GLI4 DMAP1 ZNF48 ZNF2 SENP6 FILIP1 LOC100421091
GH06F075490 1.1 Ensembl ENCODE 21.9 -107.5 -107494 6.2 TBP BMI1 FEZF1 CBX5 ZNF207 ETV6 ZNF202 ZNF362 JUNB TBX21 SENP6 FILIP1 RPL26P20
GH06F075849 0.9 Ensembl ENCODE 22.5 +248.3 248295 1.0 JUN DPF2 ZNF843 ZNF316 CTBP1 JUND GATA3 ZNF580 KLF9 MAFK SENP6 RNA5SP209 RNU6-155P
GH06F075609 0.6 ENCODE 22.3 +7.6 7641 0.2 ZNF316 MAFG EBF1 EMSY MAFK SENP6 LOC100421091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SENP6 on UCSC Golden Path with GeneCards custom track

Promoters for SENP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001220702 1291 3601 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 GLI4 DMAP1 ZNF48 ZNF2

Genomic Location for SENP6 Gene

Chromosome:
6
Start:
75,601,509 bp from pter
End:
75,718,285 bp from pter
Size:
116,777 bases
Orientation:
Plus strand

Genomic View for SENP6 Gene

Genes around SENP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP6 Gene

Proteins for SENP6 Gene

  • Protein details for SENP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR1-SENP6_HUMAN
    Recommended name:
    Sentrin-specific protease 6
    Protein Accession:
    Q9GZR1
    Secondary Accessions:
    • A6NNY9
    • O94891
    • Q5VUL3
    • Q5VUL4
    • Q8TBY4
    • Q9UJV5

    Protein attributes for SENP6 Gene

    Size:
    1112 amino acids
    Molecular mass:
    126146 Da
    Quaternary structure:
    • Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
    SequenceCaution:
    • Sequence=BAA34517.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH72480.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72481.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH74168.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH74170.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19523.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23575.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23576.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP6 Gene

Post-translational modifications for SENP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SENP6 Gene

Domains & Families for SENP6 Gene

Gene Families for SENP6 Gene

Protein Domains for SENP6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZR1

UniProtKB/Swiss-Prot:

SENP6_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP6: view

Function for SENP6 Gene

Molecular function for SENP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Enzyme Numbers (IUBMB) for SENP6 Gene

Gene Ontology (GO) - Molecular Function for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20212317
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016929 SUMO-specific protease activity IMP 20212317
genes like me logo Genes that share ontologies with SENP6: view
genes like me logo Genes that share phenotypes with SENP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP6 Gene

Localization for SENP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SENP6: view

Pathways & Interactions for SENP6 Gene

SuperPathways for SENP6 Gene

No Data Available

Pathways by source for SENP6 Gene

1 GeneTex pathway for SENP6 Gene

UniProtKB/Swiss-Prot Q9GZR1-SENP6_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Gene Ontology (GO) - Biological Process for SENP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016925 protein sumoylation IEA --
GO:0016926 protein desumoylation IMP 20212317
GO:0070646 protein modification by small protein removal IDA 20212317
GO:0090169 regulation of spindle assembly IMP 20212317
genes like me logo Genes that share ontologies with SENP6: view

No data available for SIGNOR curated interactions for SENP6 Gene

Drugs & Compounds for SENP6 Gene

(1) Drugs for SENP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SENP6: view

Transcripts for SENP6 Gene

Unigene Clusters for SENP6 Gene

SUMO1/sentrin specific peptidase 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SENP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SENP6 Gene

GeneLoc Exon Structure for
SENP6
ECgene alternative splicing isoforms for
SENP6

Expression for SENP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SENP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SENP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Testis (23.1), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SENP6 Gene



Protein tissue co-expression partners for SENP6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SENP6 Gene:

SENP6

SOURCE GeneReport for Unigene cluster for SENP6 Gene:

Hs.485784

mRNA Expression by UniProt/SwissProt for SENP6 Gene:

Q9GZR1-SENP6_HUMAN
Tissue specificity: Highly expressed in reproductive organs, such as testis, ovary and prostate.
genes like me logo Genes that share expression patterns with SENP6: view

Primer Products

No data available for mRNA differential expression in normal tissues for SENP6 Gene

Orthologs for SENP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP6 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia SENP6 34 35
  • 91.72 (n)
cow
(Bos Taurus)
Mammalia SENP6 34 35
  • 91.16 (n)
rat
(Rattus norvegicus)
Mammalia Senp6 34
  • 86.08 (n)
mouse
(Mus musculus)
Mammalia Senp6 34 16 35
  • 85.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SENP6 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP6 34 35
  • 73.08 (n)
lizard
(Anolis carolinensis)
Reptilia SENP6 35
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14557 34
zebrafish
(Danio rerio)
Actinopterygii senp6a 34 35
  • 53.22 (n)
senp6b 35
  • 34 (a)
OneToMany
Dr.3949 34
fruit fly
(Drosophila melanogaster)
Insecta CG12717 35
  • 4 (a)
ManyToMany
CG10107 35
  • 3 (a)
ManyToMany
CG41423 35
  • 1 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-4 35
  • 5 (a)
ManyToMany
ulp-2 35
  • 3 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP2 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for SENP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP6 Gene

ENSEMBL:
Gene Tree for SENP6 (if available)
TreeFam:
Gene Tree for SENP6 (if available)

Paralogs for SENP6 Gene

Paralogs for SENP6 Gene

(1) SIMAP similar genes for SENP6 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for SENP6 Gene

genes like me logo Genes that share paralogs with SENP6: view

Variants for SENP6 Gene

Sequence variations from dbSNP and Humsavar for SENP6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1018103 -- 75,679,273(-) atatg(A/C)ctggc intron-variant, utr-variant-3-prime
rs10225338 -- 75,685,795(-) ctcct(C/T)ggcaa intron-variant
rs10238956 -- 75,685,804(-) agtaa(A/G)gcact intron-variant
rs10485375 -- 75,631,206(-) TAAGA(C/G)AACCT intron-variant
rs10526946 -- 75,620,103(+) AAAAA(-/A)GAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SENP6 Gene

Variant ID Type Subtype PubMed ID
nsv522814 CNV loss 19592680
nsv1148796 CNV insertion 26484159
nsv1125881 CNV tandem duplication 24896259
nsv1032961 CNV gain 25217958
esv3609579 CNV loss 21293372
esv3576179 CNV gain 25503493
esv3540004 CNV deletion 23714750
esv2672891 CNV deletion 23128226

Variation tolerance for SENP6 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SENP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP6 Gene

Disorders for SENP6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SENP6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcocystosis
  • sarcosporidiosis
- elite association - COSMIC cancer census association via MalaCards
Search SENP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP6
genes like me logo Genes that share disorders with SENP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP6 Gene

Publications for SENP6 Gene

  1. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. (PMID: 17000875) Mukhopadhyay D. … Dasso M. (J. Cell Biol. 2006) 3 4 22 64
  2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. (PMID: 10799485) Kim K.I. … Chung C.H. (J. Biol. Chem. 2000) 3 4 22 64
  3. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. (PMID: 21148299) Hattersley N. … Hay R.T. (Mol. Biol. Cell 2011) 3 4 64
  4. The SUMO protease SENP6 is essential for inner kinetochore assembly. (PMID: 20212317) Mukhopadhyay D. … Dasso M. (J. Cell Biol. 2010) 3 4 64
  5. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. (PMID: 17704809) Cheng Z. … Yao X. (Oncogene 2008) 3 4 64

Products for SENP6 Gene

Sources for SENP6 Gene

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