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Aliases for SENP5 Gene

Aliases for SENP5 Gene

  • SUMO1/Sentrin Specific Peptidase 5 2 3
  • Sentrin/SUMO-Specific Protease SENP5 4
  • SUMO1/Sentrin Specific Protease 5 2
  • EC 3.4.22.68 4
  • EC 3.4.22 64

External Ids for SENP5 Gene

Summaries for SENP5 Gene

Entrez Gene Summary for SENP5 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP5 Gene

SENP5 (SUMO1/Sentrin Specific Peptidase 5) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP2.

UniProtKB/Swiss-Prot for SENP5 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP5 Gene

Genomics for SENP5 Gene

Genomic Location for SENP5 Gene

Start:
196,867,856 bp from pter
End:
196,934,714 bp from pter
Size:
66,859 bases
Orientation:
Plus strand

Genomic View for SENP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP5 Gene

No data available for Regulatory Elements for SENP5 Gene

Proteins for SENP5 Gene

  • Protein details for SENP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HI0-SENP5_HUMAN
    Recommended name:
    Sentrin-specific protease 5
    Protein Accession:
    Q96HI0
    Secondary Accessions:
    • B4DY82
    • Q96SA5

    Protein attributes for SENP5 Gene

    Size:
    755 amino acids
    Molecular mass:
    86693 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK69630.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP5 Gene

Proteomics data for SENP5 Gene at MOPED

Selected DME Specific Peptides for SENP5 Gene

Post-translational modifications for SENP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SENP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SENP5 Gene

Protein Domains for SENP5 Gene

UniProtKB/Swiss-Prot:

SENP5_HUMAN
Family:
  • Belongs to the peptidase C48 family.:
    • Q96HI0
genes like me logo Genes that share domains with SENP5: view

No data available for Gene Families for SENP5 Gene

Function for SENP5 Gene

Molecular function for SENP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Enzyme Numbers (IUBMB) for SENP5 Gene

Gene Ontology (GO) - Molecular Function for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21217774
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SENP5: view
genes like me logo Genes that share phenotypes with SENP5: view

miRNA for SENP5 Gene

miRTarBase miRNAs that target SENP5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SENP5 Gene

Localization for SENP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP5 Gene COMPARTMENTS Subcellular localization image for SENP5 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SENP5: view

Pathways for SENP5 Gene

genes like me logo Genes that share pathways with SENP5: view

Gene Ontology (GO) - Biological Process for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SENP5: view

Transcripts for SENP5 Gene

Unigene Clusters for SENP5 Gene

SUMO1/sentrin specific peptidase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for SENP5 Gene

GeneLoc Exon Structure for
SENP5
ECgene alternative splicing isoforms for
SENP5

Expression for SENP5 Gene

mRNA expression in normal human tissues for SENP5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SENP5 Gene

SOURCE GeneReport for Unigene cluster for SENP5 Gene Hs.240770

genes like me logo Genes that share expressions with SENP5: view

Orthologs for SENP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP5 36
  • 99.65 (n)
  • 99.6 (a)
SENP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SENP5 36
  • 91.95 (n)
  • 89.12 (a)
SENP5 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP5 36
  • 92.93 (n)
  • 90.45 (a)
SENP5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp5 36
  • 87.57 (n)
  • 82.75 (a)
Senp5 16
Senp5 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SENP5 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SENP5 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp5 36
  • 87.81 (n)
  • 84.11 (a)
chicken
(Gallus gallus)
Aves SENP5 36
  • 68.86 (n)
  • 64.29 (a)
SENP5 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP5 37
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33591 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4871 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13692 36
zebrafish
(Danio rerio)
Actinopterygii senp5 37
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11023 37
  • 19 (a)
ManyToMany
CG32110 37
  • 22 (a)
ManyToMany
Ulp1 37
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-1 37
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for SENP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP5 Gene

ENSEMBL:
Gene Tree for SENP5 (if available)
TreeFam:
Gene Tree for SENP5 (if available)

Paralogs for SENP5 Gene

Paralogs for SENP5 Gene

Selected SIMAP similar genes for SENP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SENP5: view

Variants for SENP5 Gene

Sequence variations from dbSNP and Humsavar for SENP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1602 -- 196,929,901(-) GATGA(C/T)ACCCA intron-variant
rs1061973 -- 196,931,293(+) TACTC(A/C)CAGAA utr-variant-3-prime
rs1134523 -- 196,898,792(+) CCATT(A/G/T)GAAGA intron-variant
rs1147242 -- 196,933,684(-) GGCAG(A/G)GGTTG utr-variant-3-prime
rs1147243 -- 196,933,020(-) AAAAA(A/C)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SENP5 Gene

Variant ID Type Subtype PubMed ID
nsv829829 CNV Loss 17160897
esv269151 CNV Insertion 20981092
dgv87n16 CNV Insertion 17901297

Relevant External Links for SENP5 Gene

HapMap Linkage Disequilibrium report
SENP5

Disorders for SENP5 Gene

No disorders were found for SENP5 Gene.

No data available for UniProtKB/Swiss-Prot for SENP5 Gene

Publications for SENP5 Gene

  1. The SUMO-specific protease SENP5 is required for cell division. (PMID: 16738315) Di Bacco A. … Gill G. (Mol. Cell. Biol. 2006) 2 3 4
  2. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PMID: 16608850) Gong L. … Yeh E.T.H. (J. Biol. Chem. 2006) 3 4 23
  3. Ubiquitin-like proteins: new wines in new bottles. (PMID: 10806345) Yeh E.T.H. … Kamitani T. (Gene 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SENP5 Gene

  • Addgene plasmids for SENP5

Sources for SENP5 Gene

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