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Aliases for SENP5 Gene

Aliases for SENP5 Gene

  • SUMO1/Sentrin Specific Peptidase 5 2 3 5
  • Sentrin/SUMO-Specific Protease SENP5 4
  • SUMO1/Sentrin Specific Protease 5 2
  • EC 3.4.22.68 4
  • EC 3.4.22 61

External Ids for SENP5 Gene

Previous GeneCards Identifiers for SENP5 Gene

  • GC03P197922
  • GC03P198083
  • GC03P196594
  • GC03P193894

Summaries for SENP5 Gene

Entrez Gene Summary for SENP5 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP5 Gene

SENP5 (SUMO1/Sentrin Specific Peptidase 5) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot for SENP5 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP5 Gene

Genomics for SENP5 Gene

Regulatory Elements for SENP5 Gene

Enhancers for SENP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196938 1.2 ENCODE 15.3 +74.5 74522 7.3 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC NCBP2-AS2 PIGZ SENP5 NCBP2-AS1 NCBP2
GH03G196968 1.7 FANTOM5 ENCODE dbSUPER 10.8 +101.5 101537 2.4 HNRNPUL1 PKNOX1 CREB3L1 AGO1 SIN3A ZNF48 ZNF766 GLIS2 ZNF207 ZNF143 LOC220729 UBXN7-AS1 ENSG00000249626 MELTF-AS1 PIGZ SENP5 NCBP2-AS2 NRROS GC03P196980
GH03G196790 1.3 Ensembl ENCODE 10.7 -75.3 -75269 5.1 HDGF ATF1 FOXA2 PKNOX1 ARNT SIN3A ARID4B BRCA1 ZNF2 ZBTB7B CEP19 SENP5 NCBP2-AS1 NCBP2 MELTF-AS1 PIGX PAK2 SDHAP1 TCTEX1D2 GC03M196785
GH03G196316 1.1 ENCODE 11.6 -549.8 -549776 2.8 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF207 UBXN7 TM4SF19 PCYT1A SDHAP2 ENSG00000260261 ENSG00000231443 UBXN7-AS1 RNU6ATAC24P TCTEX1D2 SLC51A
GH03G197553 1.2 ENCODE dbSUPER 10.6 +687.3 687280 2.5 HDGF PKNOX1 SIN3A BRCA1 ZNF2 ZBTB7B GLIS2 ZNF143 DEK PAF1 MELTF-AS1 BDH1 ENSG00000249626 SENP5 LOC220729 GC03P197515
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SENP5 on UCSC Golden Path with GeneCards custom track

Promoters for SENP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164470 344 1601 HDGF CREB3L1 ARNT ARID4B SIN3A YY1 ZNF143 ZNF207 SP5 ZHX2

Genomic Location for SENP5 Gene

Chromosome:
3
Start:
196,867,856 bp from pter
End:
196,934,714 bp from pter
Size:
66,859 bases
Orientation:
Plus strand

Genomic View for SENP5 Gene

Genes around SENP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP5 Gene

Proteins for SENP5 Gene

  • Protein details for SENP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HI0-SENP5_HUMAN
    Recommended name:
    Sentrin-specific protease 5
    Protein Accession:
    Q96HI0
    Secondary Accessions:
    • B4DY82
    • Q96SA5

    Protein attributes for SENP5 Gene

    Size:
    755 amino acids
    Molecular mass:
    86693 Da
    Quaternary structure:
    • Interacts with CCAR2.
    SequenceCaution:
    • Sequence=AAK69630.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SENP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP5 Gene

Selected DME Specific Peptides for SENP5 Gene

Q96HI0:
  • KVHFFNSFF
  • GQNWLNDQV
  • FVLQYCK
  • LLLIPIHLEVHWSLI

Post-translational modifications for SENP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for SENP5 Gene

Gene Families for SENP5 Gene

Protein Domains for SENP5 Gene

Suggested Antigen Peptide Sequences for SENP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HI0

UniProtKB/Swiss-Prot:

SENP5_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP5: view

Function for SENP5 Gene

Molecular function for SENP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Enzyme Numbers (IUBMB) for SENP5 Gene

Gene Ontology (GO) - Molecular Function for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0005515 protein binding IPI 21217774
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SENP5: view
genes like me logo Genes that share phenotypes with SENP5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SENP5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SENP5 Gene

Localization for SENP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP5 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SENP5 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SENP5: view

Pathways & Interactions for SENP5 Gene

genes like me logo Genes that share pathways with SENP5: view

Pathways by source for SENP5 Gene

Gene Ontology (GO) - Biological Process for SENP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0016925 protein sumoylation TAS --
GO:0016926 protein desumoylation IEA,IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SENP5: view

No data available for SIGNOR curated interactions for SENP5 Gene

Drugs & Compounds for SENP5 Gene

No Compound Related Data Available

Transcripts for SENP5 Gene

Unigene Clusters for SENP5 Gene

SUMO1/sentrin specific peptidase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SENP5

Alternative Splicing Database (ASD) splice patterns (SP) for SENP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: -
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for SENP5 Gene

GeneLoc Exon Structure for
SENP5
ECgene alternative splicing isoforms for
SENP5

Expression for SENP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SENP5 Gene

Protein differential expression in normal tissues from HIPED for SENP5 Gene

This gene is overexpressed in Spleen (41.0) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SENP5 Gene



Protein tissue co-expression partners for SENP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SENP5 Gene:

SENP5

SOURCE GeneReport for Unigene cluster for SENP5 Gene:

Hs.240770

Evidence on tissue expression from TISSUES for SENP5 Gene

  • Intestine(3.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SENP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SENP5 Gene

Orthologs for SENP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP5 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia SENP5 34 35
  • 92.93 (n)
cow
(Bos Taurus)
Mammalia SENP5 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Senp5 34
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Senp5 34 16 35
  • 87.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SENP5 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SENP5 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP5 34 35
  • 68.86 (n)
lizard
(Anolis carolinensis)
Reptilia SENP5 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4871 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33591 34
zebrafish
(Danio rerio)
Actinopterygii senp5 35
  • 39 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13692 34
fruit fly
(Drosophila melanogaster)
Insecta CG32110 35
  • 22 (a)
ManyToMany
CG11023 35
  • 19 (a)
ManyToMany
Ulp1 35
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-1 35
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for SENP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP5 Gene

ENSEMBL:
Gene Tree for SENP5 (if available)
TreeFam:
Gene Tree for SENP5 (if available)

Paralogs for SENP5 Gene

Paralogs for SENP5 Gene

(2) SIMAP similar genes for SENP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SENP5: view

Variants for SENP5 Gene

Sequence variations from dbSNP and Humsavar for SENP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000014043 -- 196,907,401(+) CAGTG(A/G)GCCAA intron-variant
rs1000045566 -- 196,876,225(+) ATTAA(A/G)TAATT intron-variant
rs1000050242 -- 196,921,583(+) TATTC(G/T)AAATA intron-variant
rs1000085752 -- 196,907,765(+) TTGCA(A/G)AAAAG intron-variant
rs1000153976 -- 196,886,020(+) CCGTA(A/G)GGAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SENP5 Gene

Variant ID Type Subtype PubMed ID
dgv5036n100 CNV gain 25217958
dgv87n16 CNV insertion 17901297
esv2763775 CNV gain+loss 21179565
esv3304873 CNV mobile element insertion 20981092
esv3342001 CNV insertion 20981092
esv3424685 CNV insertion 20981092
esv3436933 CNV insertion 20981092
esv3599293 CNV gain 21293372
nsv1001045 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1117365 CNV tandem duplication 24896259
nsv1125402 OTHER inversion 24896259
nsv593086 CNV loss 21841781
nsv829829 CNV loss 17160897
nsv956261 CNV insertion 24416366

Variation tolerance for SENP5 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SENP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SENP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP5 Gene

Disorders for SENP5 Gene

Relevant External Links for SENP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP5

No disorders were found for SENP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SENP5 Gene

Publications for SENP5 Gene

  1. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PMID: 16608850) Gong L. … Yeh E.T.H. (J. Biol. Chem. 2006) 3 4 22 64
  2. The SUMO-specific protease SENP5 is required for cell division. (PMID: 16738315) Di Bacco A. … Gill G. (Mol. Cell. Biol. 2006) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Ubiquitin-like proteins: new wines in new bottles. (PMID: 10806345) Yeh E.T.H. … Kamitani T. (Gene 2000) 3 4 64
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier R.A. … Vermeulen M. (J. Biol. Chem. 2016) 3 64

Products for SENP5 Gene

  • Addgene plasmids for SENP5

Sources for SENP5 Gene

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