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SENP5 Gene

protein-coding   GIFtS: 54
GCID: GC03P196594

SUMO1/Sentrin Specific Peptidase 5

(Previous name: SUMO1/sentrin specific protease 5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin Specific Peptidase 51 2
SUMO1/Sentrin Specific Protease 51 2
Sentrin/SUMO-Specific Protease SENP52 3
Sentrin-Specific Protease 52
EC 3.4.22.683
EC 3.4.228

External Ids:    HGNC: 284071   Entrez Gene: 2055642   Ensembl: ENSG000001192317   OMIM: 6128455   UniProtKB: Q96HI03   

Export aliases for SENP5 gene to outside databases

Previous GC identifers: GC03P197922 GC03P198083 GC03P193894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP5 Gene:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins
(see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are
responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for
the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass
SUMO conjugates (Di Bacco et al., 2006 (PubMed 16738315)).(supplied by OMIM, Jun 2009)

GeneCards Summary for SENP5 Gene:
SENP5 (SUMO1/sentrin specific peptidase 5) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to
its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity
against full-length SUMO1 or SUMO1 conjugates. Required for cell division




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SENP5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP5 promoter sequence
   Search Chromatin IP Primers for SENP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

SENP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P196594:  view genomic region     (about GC identifiers)

Start:
196,594,727 bp from pter      End:
196,661,585 bp from pter
Size:
66,859 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0 (See protein sequence)
Recommended Name: Sentrin-specific protease 5  
Size: 755 amino acids; 86693 Da
Sequence caution: Sequence=AAK69630.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96SA5

Explore the universe of human proteins at neXtProt for SENP5: NX_Q96HI0

Explore proteomics data for SENP5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for SENP5 (Q96HI0)
     FVLQYCK  KVHFFNSFF  GQNWLNDQV  LLLIPIHLEVHWSLI 


    See SENP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689912.2  
    ENSEMBL proteins: 
     ENSP00000390231   ENSP00000327197   ENSP00000396927   ENSP00000405663   ENSP00000415227  
    Reactome Protein details: Q96HI0

    SENP5 Human Recombinant Protein Products:

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    Novus Biologicals SENP5 Proteins
    Novus Biologicals SENP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SENP5

     
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    antibodies-online proteins for SENP5 (5 products) 

     
    antibodies-online peptides for SENP5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q96HI0

    ProtoNet protein and cluster: Q96HI0

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0
    Similarity: Belongs to the peptidase C48 family


    Find genes that share domains with SENP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP5_HUMAN, Q96HI0
    Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to
    its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity
    against full-length SUMO1 or SUMO1 conjugates. Required for cell division
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity IEA--
         
    Find genes that share ontologies with SENP5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SENP5:
     Increased gamma-H2AX phosphory  Increased viability after born  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SENP5

    miRNA
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    miRTarBase miRNAs that target SENP5:
    hsa-let-7d-5p (MIRT051719)

    Block miRNA regulation of human, mouse, rat SENP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP5 (see all 103):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3607-3p hsa-miR-631 hsa-miR-15a hsa-miR-106a hsa-miR-30d hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidSENP5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SENP5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SENP5 (NM_152699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SENP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP5
    Addgene plasmids for SENP5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SENP5_HUMAN, Q96HI0: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SENP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SENP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO0.00
    SUMOylation0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with SENP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SENP5
        SUMO is proteolytically processed


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP5
    Interactions:

        Search GeneGlobe Interaction Network for SENP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP5 (Q96HI01 ENSP000003271974) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033721, ENSP000002062494EBI-3895753,EBI-78473 STRING: ENSP00000206249
    KPNB1ENSP000002901584STRING: ENSP00000290158
    SENP6ENSP000004025274STRING: ENSP00000402527
    SENP7ENSP000003776554STRING: ENSP00000377655
    MRE11AENSP000003258634STRING: ENSP00000325863
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007049cell cycle IEA--
    GO:0016925protein sumoylation TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with SENP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SENP5 gene: 
    NM_152699.4  

    Unigene Cluster for SENP5:

    SUMO1/sentrin specific peptidase 5
    Hs.240770  [show with all ESTs]
    Unigene Representative Sequence: NM_152699
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445299 ENST00000323460(uc003fwz.4 uc011bty.2) ENST00000419026
    ENST00000489744 ENST00000448068 ENST00000434433 ENST00000463245
    miRNA
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    Block miRNA regulation of human, mouse, rat SENP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP5 (see all 103):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3607-3p hsa-miR-631 hsa-miR-15a hsa-miR-106a hsa-miR-30d hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidSENP5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Addgene plasmids for SENP5 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP5
      QuantiTect SYBR Green Assays in human, mouse, rat SENP5
      QuantiFast Probe-based Assays in human, mouse, rat SENP5

    Additional mRNA sequence: 

    AF335474.1 AK124389.1 AK302305.1 AK313764.1 AL049229.2 BC000958.2 BC008589.1 BC013799.1 
    BC030705.2 BC036626.1 

    17 DOTS entries:

    DT.95241467  DT.453712  DT.86853173  DT.315156  DT.120865877  DT.97836810  DT.100733229  DT.120865835 
    DT.100744003  DT.100744004  DT.86853174  DT.100678767  DT.120865911  DT.92415513  DT.100745055  DT.440279 
    DT.95078020 

    Selected AceView cDNA sequences (see all 123):

    BC008589 AA393255 BM549230 AW873169 BF171492 AI880091 BU616969 BU676009 
    AW603960 AW847746 BC000958 AW167097 AA705159 AW603962 BX095695 AI202124 
    AW847730 AW008921 AW847876 BU161479 BQ000929 AI961135 BU677598 BQ936014 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SENP5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
    SP1:                                                  -                                       
    SP2:                                                  -                       -     -         
    SP3:                                      -     -     -                                       
    SP4:                                                                                          


    ECgene alternative splicing isoforms for SENP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATTACA
    SENP5 Expression
    About this image

    SENP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.240770
        Custom PCR Arrays for SENP5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp51 , 5 SUMO/sentrin specific peptidase 51, 5 87.57(n)1
    82.75(a)1
      16 (22.40 cM)5
    3202131  NM_177103.41  NP_796077.21 
     319625065 
    chicken
    (Gallus gallus)
    Aves SENP51 SUMO1/sentrin specific peptidase 5 68.86(n)
    64.29(a)
      424955  XM_004943436.1  XP_004943493.1 
    lizard
    (Anolis carolinensis)
    Reptilia SENP56
    SUMO1/sentrin specific peptidase 5
    50(a)
    1 ↔ 1
    GL343321.1(275057-308714)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335912 Xenopus laevis transcribed sequence with weak similarity more 83.63(n)    48046335 
    zebrafish
    (Danio rerio)
    Actinopterygii senp56
    SUMO/sentrin specific peptidase 5
    39(a)
    1 ↔ 1
    22(41963964-41976243) ENSDARG00000060646
    fruit fly
    (Drosophila melanogaster)
    Insecta Ulp16
    CG321106
    (see all 3)
    --
    8(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(19096672-19102217)
    3L(12801821-12803196)
    worm
    (Caenorhabditis elegans)
    Secernentea ulp-16
    Protein ULP-1 (ulp-1) mRNA, complete cds
    15(a)
    1 → many
    III(5165661-5169799) WBGene00006736
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP16
    Protease that specifically cleaves Smt3p protein c...
    16(a)
    1 → many
    XVI(512313-514178) YPL020C


    ENSEMBL Gene Tree for SENP5 (if available)
    TreeFam Gene Tree for SENP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP5 gene
    SENP32  SENP22  SENP12  
    2 SIMAP similar genes for SENP5 using alignment to 5 protein entries:     SENP5_HUMAN (see all proteins):
    SENP3    SENP2

    Find genes that share paralogs with SENP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SENP5 (see all 1701)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719710681,2
    C--196467048(+) TTTGT-/TTTTTT 1 -- int10--------
    rs1423025481,2
    --196592730(+) AGTGTA/GAAAGA 1 -- us2k10--------
    rs1930527501,2
    --196592739(+) GACACA/GGTGAA 1 -- us2k10--------
    rs49165641,2
    C,A--196592822(+) gaggcG/Aggtgg 1 -- us2k15Minor allele frequency- A:0.12NA CSA 8
    rs1856149261,2
    --196592833(+) ATCACC/TGGAGG 1 -- us2k10--------
    rs1404294531,2
    --196592854(+) AAGACC/TGGCCT 1 -- us2k10--------
    rs1150664721,2
    F--196592938(+) TCTGGC/TTACTC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1893810551,2
    --196592984(+) AGTAGA/TTAATA 1 -- us2k10--------
    rs1499796251,2
    --196593009(+) TTATCA/GCTTGA 1 -- us2k10--------
    rs1810710721,2
    --196593056(+) GATTGC/TGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SENP5 (196594727 - 196661585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SENP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269151CNV Insertion20981092
    dgv87n16CNV Insertion17901297
    nsv829829CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612845    OMIM disorders: --


    Find genes that share disorders with SENP5           About GenesLikeMe


    Export disorders for SENP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SENP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PubMed id 16608850)1, 2, 9 Gong L. and Yeh E.T.H. (J. Biol. Chem. 2006)
    2. The SUMO-specific protease SENP5 is required for cell division. (PubMed id 16738315)1, 2 Di Bacco A.... Gill G. (Mol. Cell. Biol. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Ubiquitin-like proteins: new wines in new bottles. (PubMed id 10806345)1, 2 Yeh E.T.H.... Kamitani T. (Gene 2000)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. (PubMed id 19015314)1 Yun C.... Dasso M. (J. Cell Biol. 2008)
    8. Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. (PubMed id 18949399)1 Ding X....Chen W. (Oncol. Rep. 2008)
    9. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 205564 HGNC: 28407 AceView: SENP5 Ensembl:ENSG00000119231 euGenes: HUgn205564
    ECgene: SENP5 H-InvDB: SENP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SENP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SENP5 gene:
    Search GeneIP for patents involving SENP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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