SENP5 Gene
protein-coding GIFtS: 50
GCID: GC03P196594
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SUMO1/sentrin specific peptidase 5(Previous name: SUMO1/sentrin specific protease 5 )
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Aliases for SENP5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| SUMO1/Sentrin Specific Peptidase 51 2 | | Sentrin-Specific Protease 52 | | SUMO1/Sentrin Specific Protease 51 2 | | EC 3.4.22.683 | | Sentrin/SUMO-Specific Protease SENP52 3 | | EC 3.4.228 | | MGC270761 | | |
Export aliases for SENP5 gene to outside databasesPrevious GC identifers: GC03P197922 GC03P198083 GC03P193894 |
Summaries for SENP5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SENP5: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (seeSUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, areresponsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for theconjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMOconjugates (Di Bacco et al., 2006 (PubMed 16738315)).(supplied by OMIM, Jun 2009) UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to itsmature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity againstfull-length SUMO1 or SUMO1 conjugates. Required for cell division
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Genomic Views for SENP5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for SENP5 Other transcription factors
Search SABiosciences Chromatin IP Primers for SENP5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29SENP5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P196594: view genomic region
(about GC identifiers)
Start:
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196,594,727 bp from pter |
End:
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196,661,585 bp from pter |
Size:
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66,859 bases |
Orientation:
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plus strand |
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Proteins for SENP5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0 (See
protein sequence)Recommended Name: Sentrin-specific protease 5 Size: 755 amino acids; 86693 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAK69630.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96SA5Explore the universe of human proteins at neXtProt for SENP5: NX_Q96HI0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HI0 4 DME Specific Peptides for SENP5 (Q96HI0)
SENP5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689912.2 ENSEMBL proteins: ENSP00000327197 ENSP00000390231 ENSP00000396927 ENSP00000405663 ENSP00000415227 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
SENP5 for ontologies About GeneDecksing
SENP5 Antibody Products: Assay Products for SENP5: |
Protein
Domains / Families for SENP5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SENP5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96HI0ProtoNet protein and cluster: Q96HI0 1 Blocks protein family: IPB003653 SUMO/Sentrin/Ubl1 specific protease
UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0Similarity: Belongs to the peptidase C48 family |
Function for SENP5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SENP5_HUMAN, Q96HI0Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to itsmature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity againstfull-length SUMO1 or SUMO1 conjugates. Required for cell divisionCatalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminalend of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A secondreaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO andthe lysine epsilon-amino group of the target proteinEnzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SENP5 (NM_152699) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP5  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
SENP5 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SENP5:
|
Pathways & Interactions for SENP5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SENP5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for SENP5 (Q96HI01 ENSP000003271974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SENP5 for ontologies About GeneDecksing
|
Drugs & Compounds for SENP5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SENP5 Search CenterWatch for drugs/clinical trials and news about SENP5 
|
Transcripts for SENP5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SENP5 gene: NM_152699.4 Unigene Cluster for SENP5: SUMO1/sentrin specific peptidase 5 Hs.240770 [show with all ESTs]Unigene Representative Sequence: NM_1526997 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323460(uc003fwz.4 uc011bty.2) ENST00000445299 ENST00000419026 ENST00000489744 ENST00000448068 ENST00000434433 ENST00000463245
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SENP5 (NM_152699) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP5  |
Additional cDNA sequence: AF335474.1 AK124389.1 AK302305.1 AK313764.1 AL049229.2 BC000958.2 BC008589.1 BC013799.1 BC030705.2 BC036626.1 17 DOTS entries: DT.95241467 DT.453712 DT.86853173 DT.315156 DT.120865877 DT.97836810 DT.100733229 DT.120865835 DT.100744003 DT.100744004 DT.86853174 DT.100678767 DT.120865911 DT.92415513 DT.100745055 DT.440279 DT.95078020 24/123 AceView cDNA sequences (see all 123): AW008921 AI961135 BF171492 AW603964 BE042575 AW603960 AA705159 BU161479 AW847876 BX095695 BQ936014 BC008589 AW847730 BQ000929 BU676009 AW603962 AI202124 AI880091 BU616969 CR597398 BC000958 AW847746 AW167097 AW873169 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SENP5 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SENP5
|
Expression for SENP5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SENP5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAAATTACA
About this image See SENP5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SENP5
SOURCE GeneReport for Unigene cluster: Hs.240770 SABiosciences Custom PCR Arrays for SENP5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SENP5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SENP5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP5 |
Orthologs for SENP5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SENP5 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SENP5 (if available) TreeFam Gene Tree for SENP5 (if available)  |
Paralogs for SENP5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SENP5 gene
- SENP32 SENP22 SENP12
2 SIMAP similar genes for SENP5 using alignment to 5 protein entries: SENP5_HUMAN (see all proteins):SENP3 SENP2
SENP5 for paralogs About GeneDecksing
|
Genomic Variants for SENP5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SENP5 (196594727 - 196661585 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for SENP5 1 CNV: 4369 2 Inversions: 37243 0568  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP5 |
|
Disorders
/ Diseases for SENP5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SENP5 for disorders About GeneDecksing
OMIM gene information: 612845
OMIM disorders: --
4 diseases for SENP5: About MalaCardsoral squamous cell carcinoma squamous cell carcinoma carcinoma malaria Export disorders for SENP5 gene to outside databases
|
Publications for SENP5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SENP5 gene integrated from 9 sources: (articles sorted by number of sources associating them with SENP5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PubMed id 16608850)1, 2, 9 Gong L. and Yeh E.T.H. (2006)
- The SUMO-specific protease SENP5 is required for cell division. (PubMed id 16738315)1, 2 Di Bacco A.... Gill G. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-like proteins: new wines in new bottles. (PubMed id 10806345)1, 2 Yeh E.T.H.... Kamitani T. (2000)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. (PubMed id 19015314)1 Yun C.... Dasso M. (2008)
- Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. (PubMed id 18949399)1 Ding X....Chen W. (2008)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
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External Searches for SENP5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SENP5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SENP5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SENP5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SENP5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SENP5 gene: Search GeneIP for patents involving SENP5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SENP5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SENP5 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP5 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP5 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SENP5 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP5 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP5 |
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| | | Search Tocris compounds for SENP5 |
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 | | SENP5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP5 |
|  |  |  | | | ThermoFisher Antibody for SENP5 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP5 |
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