SENP3 Gene
protein-coding GIFtS: 56
GCID: GC17P007467
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SUMO1/sentrin/SMT3 specific peptidase 3(Previous name: SUMO1/sentrin/SMT3 specific protease 3 )
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Aliases
for SENP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SUMO1/Sentrin/SMT3 Specific Peptidase 31 2 | | SUMO1/Sentrin/SMT3 Specific Protease 31 | | SSP31 2 3 | | Sentrin-Specific Protease 32 | | SMT3IP11 2 | | Sentrin/SUMO-Specific Protease 32 | | Ulp11 2 | | EC 3.4.22.683 | | SUMO-1-Specific Protease 32 3 | | SUSP33 | | DKFZP586K09191 | | Sentrin/SUMO-Specific Protease SENP33 | | DKFZp762A1521 | | EC 3.4.228 |
Export aliases for SENP3 gene to outside databasesPrevious GC identifers: GC17U990165 GC17P008205 GC17P007408 GC17P007666 GC17P007406 GC17P007359 |
Summaries
for SENP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SENP3:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (seeSUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, areresponsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for theconjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMOconjugates (Di Bacco et al., 2006 (PubMed 16738315)).(supplied by OMIM, Jun 2009)
UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4Function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activityagainst SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as aneffector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing throughdeconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status ofZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruitedto ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 targetgenes
Gene Wiki entry for SENP3
|
Genomic Views
for SENP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SENP3 gene promoter:
PPAR-gamma1 p53 deltaCREB ATF-2 MyoD PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SENP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13SENP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007467: view genomic region
(about GC identifiers)
Start:
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7,465,192 bp from pter |
End:
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7,475,287 bp from pter |
Size:
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10,096 bases |
Orientation:
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plus strand |
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Proteins
for SENP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4 (See
protein sequence)Recommended Name: Sentrin-specific protease 3 Size: 574 amino acids; 65010 Da
Subunit: Binds to SUMO1 and SUMO3 (By similarity). Component of some MLL1/MLL complex, at least composed of the corecomponents MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70,INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3,TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. Component of the 5FMC complex, at leastcomposed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interactswith NOL9
Subcellular location: Cytoplasm (By similarity). Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in thenucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributesbetween the nucleolus and the nucleoplasm in response to mild oxidative stress
Secondary accessions: Q66K15 Q86VS7 Q96PS4 Q9Y3W9Explore the universe of human proteins at neXtProt for SENP3: NX_Q9H4L4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4L4
4 DME Specific Peptides for SENP3 (Q9H4L4)
SENP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056485.2
ENSEMBL proteins: ENSP00000463358 ENSP00000464172 ENSP00000462461 ENSP00000314029 ENSP00000403712
Human Recombinant Protein Products for SENP3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SENP3 for ontologies About GeneDecksing
SENP3 Antibody Products:
Assay Products for SENP3: |
Protein
Domains /
Families
for SENP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SENP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H4L4ProtoNet protein and cluster: Q9H4L4 1 Blocks protein family: IPB003653 SUMO/Sentrin/Ubl1 specific protease
UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4Similarity: Belongs to the peptidase C48 family |
Function
for SENP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SENP3_HUMAN, Q9H4L4Function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activityagainst SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as aneffector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing throughdeconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status ofZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruitedto ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 targetgenesCatalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminalend of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A secondreaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO andthe lysine epsilon-amino group of the target proteinEnzyme regulation: On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, whichstabilizes it as it accumulates in the nucleoplasm Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004843 | ubiquitin-specific protease activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- | | GO:0008234 | cysteine-type peptidase activity |
-- | -- |
SENP3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SENP3:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SENP3 (NM_015670) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP3 |
|
Pathways & Interactions
for SENP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for SENP3
SENP3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SENP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/575 Interacting proteins for SENP3 (Q9H4L42, 3 ENSP000003140294) via UniProtKB, MINT, STRING, and/or I2D (see all 575)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| NPM1 | P067482, 3, ENSP000002969304 | MINT-8150033 MINT-6541744 MINT-6541756 MINT-6541718 MINT-6541768 MINT-6541788 MINT-7947479 MINT-8151622 I2D:
score=2 STRING: ENSP00000296930 | | WDR18 | Q9BV382, 3, ENSP000002512894 | MINT-8151602 MINT-8150033 MINT-8151587 MINT-7947479 MINT-8151622 I2D:
score=1 STRING: ENSP00000251289 | | TEX10 | Q9NXF12, 3, ENSP000003640374 | MINT-8151574 MINT-8151622 I2D:
score=1 STRING: ENSP00000364037 | | HIF1A | Q166652, 3, ENSP000003380184 | MINT-7941496 I2D:
score=1 STRING: ENSP00000338018 | | PARP1 | P098742, 3, ENSP000003557594 | MINT-7947479 I2D:
score=1 STRING: ENSP00000355759 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0019538 | protein metabolic process |
-- | -- |
SENP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SENP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SENP3
Search CenterWatch for drugs/clinical trials and news about SENP3
|
Transcripts
for SENP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SENP3 gene: NM_015670.5 Unigene Cluster for SENP3: SUMO1/sentrin/SMT3 specific peptidase 3 Hs.513926 [show with all ESTs]Unigene Representative Sequence: NM_01567011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000578868(uc002ghm.3) ENST00000583277(uc002ghn.1) ENST00000580997
ENST00000580231 ENST00000580042 ENST00000578813 ENST00000582789 ENST00000581093
ENST00000581010 ENST00000321337 ENST00000429205
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SENP3 (NM_015670) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP3 |
Additional cDNA sequence: BC048306.1 BC080658.1 17 DOTS entries: DT.100029459 DT.100830212 DT.453953 DT.100700035 DT.87016746 DT.100837871 DT.120901534 DT.87016743 DT.87011433 DT.100779151 DT.102839982 DT.120901450 DT.86844015 DT.91988614 DT.97855637 DT.100029458 DT.120901553 24 AceView cDNA sequences: BM560775 BU517271 BM806502 AA564852 AU117446 CR598185 BQ340309 F12840 BM449897 AK000923 AA424370 AA339807 CA488320 AA086016 CR616029 CR626749 BM806659 AA297204 BI962898 NM_015670 AA086106 AA424510 AU144276 BI966736
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SENP3 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SENP3
|
Expression
for SENP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SENP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGTCCCTT
About this image
See SENP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SENP3
SOURCE GeneReport for Unigene cluster: Hs.513926
SABiosciences Custom PCR Arrays for SENP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SENP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SENP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP3 |
Orthologs
for SENP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SENP3 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for SENP3 (if available)
TreeFam Gene Tree for SENP3 (if available) |
Paralogs
for SENP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SENP3 gene
- SENP22 SENP12 SENP52
1 SIMAP similar gene for SENP3 using alignment to 5 protein entries: SENP3_HUMAN (see all proteins):SENP5
SENP3 for paralogs About GeneDecksing
|
Genomic Variants
for SENP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SENP3 (7465192 - 7475287 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SENP3: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SENP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SENP3 for disorders About GeneDecksing
OMIM gene information: 612844
OMIM disorders: --
5  diseases for SENP3: About MalaCardsmeningioma pancreatic cancer pancreatitis malaria
leukemia
Human Genome Epidemiology (HuGE) Navigator: SENP3 (8 documents)
Export disorders for SENP3 gene to outside databases
|
Publications
for SENP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SENP3 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with SENP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Ubiquitin-like proteins: new wines in new bottles. (PubMed id 10806345)1, 2, 3 Yeh E.T.H.... Kamitani T. (2000)
- RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PubMed id 18946085)1, 2 Klein U.R.... Muller S. (2009)
- SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. (PubMed id 19680224)1, 2 Huang C.... Yi J. (2009)
- The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. (PubMed id 18259216)1, 2 Haindl M.... Muller S. (2008)
- Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. (PubMed id 19015314)1, 2 Yun C.... Dasso M. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. (PubMed id 16608850)1, 2 Gong L. and Yeh E.T.H. (2006)
- Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. (PubMed id 15743823)1, 2 Gregoire S. and Yang X.-J. (2005)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
|
External Searches for SENP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SENP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SENP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SENP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SENP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SENP3 gene:
Search GeneIP for patents involving SENP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SENP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for SENP3 | | OriGene shRNA RFP for SENP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SENP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SENP3 | | | OriGene Protein Over-expression Lysate for SENP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SENP3 | | OriGene 3'-UTR Clone for SENP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SENP3 | | OriGene Custom Protein Services for SENP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SENP3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SENP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP3 |
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| | Antibodies & Assays for SENP3 |
| | | | Search Tocris compounds for SENP3 |
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 | | | SENP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP3 |
|  |  |  |  | | | | ThermoFisher Antibody for SENP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP3 |
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