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Aliases for SENP3 Gene

Aliases for SENP3 Gene

  • SUMO1/Sentrin/SMT3 Specific Peptidase 3 2 3
  • SUMO-1-Specific Protease 3 3 4
  • SSP3 3 4
  • SUMO1/Sentrin/SMT3 Specific Protease 3 2
  • Sentrin/SUMO-Specific Protease SENP3 4
  • Sentrin/SUMO-Specific Protease 3 3
  • Sentrin-Specific Protease 3 3
  • EC 3.4.22.68 4
  • EC 3.4.22 63
  • SMT3IP1 3
  • SUSP3 4
  • Ulp1 3

External Ids for SENP3 Gene

Previous GeneCards Identifiers for SENP3 Gene

  • GC17U990165
  • GC17P008205
  • GC17P007408
  • GC17P007666
  • GC17P007406
  • GC17P007467
  • GC17P007359

Summaries for SENP3 Gene

Entrez Gene Summary for SENP3 Gene

  • The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SENP3 Gene

SENP3 (SUMO1/Sentrin/SMT3 Specific Peptidase 3) is a Protein Coding gene. Among its related pathways are Protein Stability. GO annotations related to this gene include ubiquitin-specific protease activity. An important paralog of this gene is SENP5.

UniProtKB/Swiss-Prot for SENP3 Gene

  • Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Wiki entry for SENP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP3 Gene

Genomics for SENP3 Gene

Regulatory Elements for SENP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SENP3 Gene

Start:
7,561,875 bp from pter
End:
7,571,969 bp from pter
Size:
10,095 bases
Orientation:
Plus strand

Genomic View for SENP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP3 Gene

Proteins for SENP3 Gene

  • Protein details for SENP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4L4-SENP3_HUMAN
    Recommended name:
    Sentrin-specific protease 3
    Protein Accession:
    Q9H4L4
    Secondary Accessions:
    • Q66K15
    • Q86VS7
    • Q96PS4
    • Q9Y3W9

    Protein attributes for SENP3 Gene

    Size:
    574 amino acids
    Molecular mass:
    65010 Da
    Quaternary structure:
    • Binds to SUMO1 and SUMO3 (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.

neXtProt entry for SENP3 Gene

Proteomics data for SENP3 Gene at MOPED

Selected DME Specific Peptides for SENP3 Gene

Post-translational modifications for SENP3 Gene

  • Ubiquitination at Lys43 and Lys446
  • Modification sites at PhosphoSitePlus

Other Protein References for SENP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SENP3 (SENP3)

Domains for SENP3 Gene

Protein Domains for SENP3 Gene

Suggested Antigen Peptide Sequences for SENP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4L4

UniProtKB/Swiss-Prot:

SENP3_HUMAN :
  • Q9H4L4
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP3: view

No data available for Gene Families for SENP3 Gene

Function for SENP3 Gene

Molecular function for SENP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot EnzymeRegulation:
On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm.
UniProtKB/Swiss-Prot Function:
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Enzyme Numbers (IUBMB) for SENP3 Gene

Gene Ontology (GO) - Molecular Function for SENP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18259216
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with SENP3: view

Phenotypes for SENP3 Gene

genes like me logo Genes that share phenotypes with SENP3: view

Animal Model Products

miRNA for SENP3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SENP3 Gene

Localization for SENP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP3 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP3 Gene COMPARTMENTS Subcellular localization image for SENP3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SENP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with SENP3: view

Pathways for SENP3 Gene

SuperPathways for SENP3 Gene

Superpath Contained pathways
1 Protein Stability
genes like me logo Genes that share pathways with SENP3: view

Pathways by source for SENP3 Gene

1 Cell Signaling Technology pathway for SENP3 Gene

Gene Ontology (GO) - Biological Process for SENP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with SENP3: view

Transcripts for SENP3 Gene

mRNA/cDNA for SENP3 Gene

Unigene Clusters for SENP3 Gene

SUMO1/sentrin/SMT3 specific peptidase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SENP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SENP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for SENP3 Gene

GeneLoc Exon Structure for
SENP3
ECgene alternative splicing isoforms for
SENP3

Expression for SENP3 Gene

mRNA expression in normal human tissues for SENP3 Gene

Protein differential expression in normal tissues for SENP3 Gene

This gene is overexpressed in Testis (17.8), Fetal Brain (8.4), Fetal ovary (7.1), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SENP3 Gene

SOURCE GeneReport for Unigene cluster for SENP3 Gene Hs.513926

genes like me logo Genes that share expressions with SENP3: view

Expression partners for SENP3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SENP3 Gene

Orthologs for SENP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SENP3 35
  • 93.44 (n)
  • 96.17 (a)
SENP3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP3 35
  • 93.5 (n)
  • 96.17 (a)
SENP3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp3 35
  • 90.79 (n)
  • 95.25 (a)
Senp3 16
Senp3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SENP3 35
  • 99.77 (n)
  • 99.83 (a)
SENP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp3 35
  • 90.96 (n)
  • 95.6 (a)
oppossum
(Monodelphis domestica)
Mammalia SENP3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP3 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.11787 35
eif4a1a 36
  • 46 (a)
OneToMany
senp3a 36
  • 49 (a)
OneToMany
senp3b 36
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13156 35
fruit fly
(Drosophila melanogaster)
Insecta CG11023 36
  • 15 (a)
ManyToMany
CG32110 36
  • 18 (a)
ManyToMany
Ulp1 36
  • 6 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ulp-1 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 36
  • 13 (a)
OneToMany
ULP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SENP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP3 Gene

ENSEMBL:
Gene Tree for SENP3 (if available)
TreeFam:
Gene Tree for SENP3 (if available)

Paralogs for SENP3 Gene

Paralogs for SENP3 Gene

Selected SIMAP similar genes for SENP3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SENP3: view

Variants for SENP3 Gene

Sequence variations from dbSNP and Humsavar for SENP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_051544 -

Structural Variations from Database of Genomic Variants (DGV) for SENP3 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Relevant External Links for SENP3 Gene

HapMap Linkage Disequilibrium report
SENP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP3 Gene

Disorders for SENP3 Gene

Relevant External Links for SENP3

Genetic Association Database (GAD)
SENP3
Human Genome Epidemiology (HuGE) Navigator
SENP3

No disorders were found for SENP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SENP3 Gene

Publications for SENP3 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Ubiquitin-like proteins: new wines in new bottles. (PMID: 10806345) Yeh E.T.H. … Kamitani T. (Gene 2000) 2 3 4
  3. The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. (PMID: 18259216) Haindl M. … Muller S. (EMBO Rep. 2008) 3 4
  4. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. (PMID: 19015314) Yun C. … Dasso M. (J. Cell Biol. 2008) 3 4
  5. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. (PMID: 19680224) Huang C. … Yi J. (EMBO J. 2009) 3 4

Products for SENP3 Gene

  • Addgene plasmids for SENP3

Sources for SENP3 Gene

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