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SENP3 Gene

protein-coding   GIFtS: 59
GCID: GC17P007467

SUMO1/Sentrin/SMT3 Specific Peptidase 3

(Previous name: SUMO1/sentrin/SMT3 specific protease 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin/SMT3 Specific Peptidase 31 2     Sentrin-Specific Protease 32
SSP32 3     Sentrin/SUMO-Specific Protease 32
SUMO-1-Specific Protease 32 3     EC 3.4.22.683
SUMO1/Sentrin/SMT3 Specific Protease 31     SUSP33
SMT3IP12     Sentrin/SUMO-Specific Protease SENP33
Ulp12     EC 3.4.228

External Ids:    HGNC: 178621   Entrez Gene: 261682   Ensembl: ENSG000001619567   OMIM: 6128445   UniProtKB: Q9H4L43   

Export aliases for SENP3 gene to outside databases

Previous GC identifers: GC17U990165 GC17P008205 GC17P007408 GC17P007666 GC17P007406 GC17P007359


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP3 Gene:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins
(see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are
responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for
the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass
SUMO conjugates (Di Bacco et al., 2006 (PubMed 16738315)).(supplied by OMIM, Jun 2009)

GeneCards Summary for SENP3 Gene:
SENP3 (SUMO1/sentrin/SMT3 specific peptidase 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity. An important paralog of this gene is SENP2.

UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4
Function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity
against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation
capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can
act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing
through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation
status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC
complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
transactivation of ZNF148 target genes

Gene Wiki entry for SENP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP3 gene promoter:
         PPAR-gamma1   p53   deltaCREB   ATF-2   MyoD   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP3 promoter sequence
   Search Chromatin IP Primers for SENP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

SENP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007467:  view genomic region     (about GC identifiers)

Start:
7,465,192 bp from pter      End:
7,475,287 bp from pter
Size:
10,096 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4 (See protein sequence)
Recommended Name: Sentrin-specific protease 3  
Size: 574 amino acids; 65010 Da
Subunit: Binds to SUMO1 and SUMO3 (By similarity). Component of some MLL1/MLL complex, at least composed of the
core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8,
E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A,
RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. Component of
the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with
methylated CHTOP and ZNF148. Interacts with NOL9
Secondary accessions: Q66K15 Q86VS7 Q96PS4 Q9Y3W9

Explore the universe of human proteins at neXtProt for SENP3: NX_Q9H4L4

Explore proteomics data for SENP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys446
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for SENP3 (Q9H4L4)
     FVLQYCK  KVHFFNSFF  GQNWLNDQV  LLLIPIHLEVHWSLI 


    See SENP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056485.2  
    ENSEMBL proteins: 
     ENSP00000463358   ENSP00000464172   ENSP00000462461   ENSP00000314029   ENSP00000403712  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9H4L4

    ProtoNet protein and cluster: Q9H4L4

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP3_HUMAN, Q9H4L4
    Similarity: Belongs to the peptidase C48 family


    Find genes that share domains with SENP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP3_HUMAN, Q9H4L4
    Function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity
    against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation
    capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can
    act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing
    through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation
    status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC
    complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
    transactivation of ZNF148 target genes
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein
    Enzyme regulation: On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which
    stabilizes it as it accumulates in the nucleoplasm

         Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IEA--
    GO:0005515protein binding IPI18259216
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with SENP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SENP3:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SENP3

    miRNA
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    miRTarBase miRNAs that target SENP3:
    hsa-mir-296-3p (MIRT038466), hsa-mir-320a (MIRT044811), hsa-mir-18a-3p (MIRT040884), hsa-mir-30c-5p (MIRT048004)

    Block miRNA regulation of human, mouse, rat SENP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP3 (see all 16):
    hsa-miR-3128 hsa-miR-132* hsa-miR-34b* hsa-miR-410 hsa-miR-501-5p hsa-miR-1286 hsa-miR-3163 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidSENP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SENP3_HUMAN, Q9H4L4: Cytoplasm (By similarity). Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in
    the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).
    Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0071339MLL1 complex IDA15960975

    Find genes that share ontologies with SENP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SENP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability


    Find genes that share SuperPaths with SENP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SENP3
        Protein Stability


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP3
    Interactions:

        GeneGlobe Interaction Network for SENP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP3 (Q9H4L41, 2, 3 ENSP000003140294) via UniProtKB, MINT, STRING, and/or I2D (see all 657)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPM1P067481, 2, 3, ENSP000002969304EBI-2880236,EBI-78579 MINT-8150033 MINT-6541744 MINT-6541756 MINT-6541718 MINT-6541768 MINT-6541788 MINT-7947479 MINT-8151622 I2D: score=2 STRING: ENSP00000296930
    WDR18Q9BV381, 2, 3, ENSP000002512894EBI-2880236,EBI-727429 MINT-8151602 MINT-8150033 MINT-8151587 MINT-7947479 MINT-8151622 I2D: score=1 STRING: ENSP00000251289
    TEX10Q9NXF11, 2, 3, ENSP000003640374EBI-2880236,EBI-2371062 MINT-8151574 MINT-8151622 I2D: score=1 STRING: ENSP00000364037
    HIF1AQ166652, 3, ENSP000003380184MINT-7941496 I2D: score=1 STRING: ENSP00000338018
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0019538protein metabolic process ----

    Find genes that share ontologies with SENP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SENP3 gene: 
    NM_015670.5  

    Unigene Cluster for SENP3:

    SUMO1/sentrin/SMT3 specific peptidase 3
    Hs.513926  [show with all ESTs]
    Unigene Representative Sequence: NM_015670
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578868(uc002ghm.3) ENST00000583277(uc002ghn.1) ENST00000580997
    ENST00000580231 ENST00000580042 ENST00000578813 ENST00000582789 ENST00000581093
    ENST00000581010 ENST00000321337 ENST00000429205
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    hsa-miR-3128 hsa-miR-132* hsa-miR-34b* hsa-miR-410 hsa-miR-501-5p hsa-miR-1286 hsa-miR-3163 hsa-miR-561
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      QuantiFast Probe-based Assays in human, mouse, rat SENP3

    Additional mRNA sequence: 

    BC048306.1 BC080658.1 

    17 DOTS entries:

    DT.100029459  DT.100830212  DT.453953  DT.100700035  DT.87016746  DT.100837871  DT.120901534  DT.87016743 
    DT.87011433  DT.100779151  DT.102839982  DT.120901450  DT.86844015  DT.91988614  DT.97855637  DT.100029458 
    DT.120901553 

    24 AceView cDNA sequences:

    BM449897 BM806659 CR626749 BU517271 CR616029 AA424370 AA564852 AU117446 
    BI962898 F12840 CR598185 BM560775 AA086016 AA339807 AA297204 AK000923 
    CA488320 BQ340309 BM806502 NM_015670 AA086106 AU144276 AA424510 BI966736 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SENP3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                    -                 -                                                         
    SP2:                                      -                 -                                       
    SP3:                                                                          -                     
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SENP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTCCCTT
    SENP3 Expression
    About this image

    SENP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513926
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp31 , 5 SUMO/sentrin specific peptidase 31, 5 90.79(n)1
    95.25(a)1
      11 (42.86 cM)5
    808861  NM_030702.41  NP_109627.31 
     696731155 
    lizard
    (Anolis carolinensis)
    Reptilia SENP36
    SUMO1/sentrin/SMT3 specific peptidase 3
    58(a)
    1 ↔ 1
    GL344106.1(31471-47249)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480117862   -- 74.47(n)    48011786 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.117872 Transcribed sequence with moderate similarity to protein more 76.59(n)    BM185366.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ulp16
    CG321106
    (see all 3)
    --
    6(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(19096672-19102217)
    3L(12801821-12803196)
    worm
    (Caenorhabditis elegans)
    Secernentea ulp-16
    Protein ULP-1 (ulp-1) mRNA, complete cds
    13(a)
    1 → many
    III(5165661-5169799) WBGene00006736
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP2(YIL031W)4 Peptidase that deconjugates Smt3/SUMO-1 peptides from more   --   9(292633-295737) 854780  NP_012233.1 


    ENSEMBL Gene Tree for SENP3 (if available)
    TreeFam Gene Tree for SENP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP3 gene
    SENP22  SENP12  SENP52  
    1 SIMAP similar gene for SENP3 using alignment to 5 protein entries:     SENP3_HUMAN (see all proteins):
    SENP5

    Find genes that share paralogs with SENP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SENP3 (see all 219)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838559781,2
    --7359920(+) GTGCCC/GGGTTG 1 -- int10--------
    rs1408329811,2
    --7360092(+) TTGAGA/TTGACC 1 -- int10--------
    rs1146929701,2
    F--7360148(+) TCTCCC/TATTCC 1 -- int11Minor allele frequency- T:0.01WA 118
    rs561367121,2
    C,F--7360208(+) CATGTC/ACCTGA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1874973091,2
    --7360239(+) GGGCCC/TTCAAA 1 -- int10--------
    rs1918966201,2
    --7360268(+) TAAAAC/TAAAGA 1 -- int10--------
    rs1840879171,2
    --7360338(+) GGCCTG/TCTGCT 1 -- int10--------
    rs1446787971,2
    C,F--7360569(+) TCAGGG/ATACTG 1 -- ut511Minor allele frequency- A:0.00EU 461
    rs1868693621,2
    --7360700(+) ACCCCG/TACTCA 2 R L mis10--------
    rs116563831,2
    H--7360919(+) CCCTTC/GCCGCC 2 S C mis10--------

    HapMap Linkage Disequilibrium report for SENP3 (7465192 - 7475287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SENP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SENP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612844    OMIM disorders: --


    Find genes that share disorders with SENP3           About GenesLikeMe

    Genetic Association Database (GAD): SENP3
    Human Genome Epidemiology (HuGE) Navigator: SENP3 (8 documents)

    Export disorders for SENP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP3 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with SENP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Ubiquitin-like proteins: new wines in new bottles. (PubMed id 10806345)1, 2, 3 Yeh E.T.H.... Kamitani T. (Gene 2000)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    7. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PubMed id 18946085)1, 2 Klein U.R.... Muller S. (Mol. Biol. Cell 2009)
    8. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. (PubMed id 19680224)1, 2 Huang C.... Yi J. (EMBO J. 2009)
    9. The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. (PubMed id 18259216)1, 2 Haindl M.... Muller S. (EMBO Rep. 2008)
    10. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. (PubMed id 19015314)1, 2 Yun C.... Dasso M. (J. Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26168 HGNC: 17862 AceView: SENP3 Ensembl:ENSG00000161956 euGenes: HUgn26168
    ECgene: SENP3 H-InvDB: SENP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SENP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SENP3 gene:
    Search GeneIP for patents involving SENP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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